subject:(Vaccines)

Massey University

1. Rubio Reyes, Patricia. Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis.

Degree: PhD, Microbiology, 2017, Massey University

► Tuberculosis was in 1993 declared as a re-emerging disease by the World Health Organization. The only vaccine currently available, BCG, an attenuated strain of Mycobacterium… (more)

▼ Tuberculosis was in 1993 declared as a re-emerging disease by the World Health Organization. The only vaccine currently available, BCG, an attenuated strain of Mycobacterium bovis, does not protect adults against the pulmonary disease, which is the form of transmission. New vaccine candidates are being developed to provide protection against tuberculosis. Subunit vaccines offer a safer alternative than whole cell preparations and provide the possibility of utilizing only the components that mediate protective immune responses. This thesis describes the production of bacterially derived polyhydroxyalkanoate (PHA) beads for use as a delivery system for Mycobacterium tuberculosis reverse vaccinology antigens and immune modulators. In the first study, the immunogenicity of beads derived from an endotoxin-free host, Clear coli, displaying M. tuberculosis antigens Rv1626, Rv2032 and Rv1789 was evaluated in mice. Beads displaying Rv1626 were selected for further studies based on the magnitude and specificity of the immune response elicited. In a final study, the immune modulators Cpe30, CS.T3378-395 and Flagellin were co-displayed with Rv1626 antigen on beads and the immunogenicity of these functionalised beads evaluated in mice. Vaccinations with Rv1626 beads and the immune modulators Cpe30 and CS. T3378-395 induced a Th1/Th17 skewed immune response. These beads were then assessed for their ability to protect mice against aerosol challenge with Mycobacterium bovis. Rv1626 beads reduced the bacterial loads in 0.48 log10 compared with the negative control group but the inclusion of immune modulators did not enhance the immunogenicity or protection induced by Rv1626 beads. This study has demonstrated the potential of PHA beads delivering a single reverse vaccinology antigen for protection against tuberculosis infection in mice. While the co-display of immune modulators did not improve the protection induced by the antigen, further studies are needed to determine optimal doses for delivery of immune modulators to enhance protective immunity.

Subjects/Keywords: Tuberculosis vaccines; Biotechnology; Vaccines

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APA (6^th Edition):

Rubio Reyes, P. (2017). Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis. (Doctoral Dissertation). Massey University. Retrieved from http://hdl.handle.net/10179/13587

Chicago Manual of Style (16^th Edition):

Rubio Reyes, Patricia. “Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis.” 2017. Doctoral Dissertation, Massey University. Accessed January 15, 2021. http://hdl.handle.net/10179/13587.

MLA Handbook (7^th Edition):

Rubio Reyes, Patricia. “Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis.” 2017. Web. 15 Jan 2021.

Vancouver:

Rubio Reyes P. Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis. [Internet] [Doctoral dissertation]. Massey University; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10179/13587.

Council of Science Editors:

Rubio Reyes P. Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis. [Doctoral Dissertation]. Massey University; 2017. Available from: http://hdl.handle.net/10179/13587

2. Gibson, Dustin. The readiness, need for, and effect of mhealth interventions to improve immunization timeliness and coverage in rural western Kenya.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/37995

► Background: As mobile phone ownership levels grow globally, opportunities to target hard-to-reach populations through mobile-health technologies become more realistic. In a rural Kenyan population, this… (more)

▼ Background: As mobile phone ownership levels grow globally, opportunities to target hard-to-reach populations through mobile-health technologies become more realistic. In a rural Kenyan population, this dissertation seeks to assess the magnitude and risk factors of immunization timeliness and coverage, to determine the readiness of a community for mHealth interventions by assessing prevalence and risk factors for mobile phone ownership and SMS utilization, and to assess the effect of the Mobile Solutions for Immunization (M-SIMU) cluster randomized controlled trial. Methods: A cross-sectional survey of Kenyan caregivers was conducted to collect baseline immunization and mobile phone ownership estimates for M-SIMU. Predictors of mobile phone ownership were obtained through multivariable logistic regression. Risk factors for delayed immunizations and not receiving immunization were calculated using binomial regression with log link. The M-SIMU trial randomized villages to four arms: Control, short message system (SMS) reminders only, SMS reminders + 75 Kenyan Schillings (KSH) incentive or, SMS reminders + 200 KSH incentive. Inverse Kaplan-Meier curves and Cox regressions assessed the intervention’s effect on pentavalent3 and measles vaccination. Results: Older maternal age, higher maternal literacy and education, smaller households, and higher socioeconomic status were associated with phone ownership. Immunization coverage for the third dose of pentavalent vaccine (pentavalent3), measles, and fully immunized children (FIC) were 95%, 83%, and 80%, respectively. Delayed pentavalent1 was associated with not receiving pentavalent3 (RR: 5.61; 95%CI: 3.77-8.33), measles vaccine (RR: 1.51; 95%CI: 1.15-1.99), and FIC (RR: 1.87; 95%CI: 1.51-2.32). The prevalence of delayed pentavalent1, pentavalent3, and measles were 11%, 24%, and 29%, respectively. No common risk factors in the delay models were found. For M-SIMU, Kaplan-Meier curves found significant differences across arms in time to pentavalent3 (p<0.01) but not measles vaccination (p=0.10). SMS + 200 KSH infants were associated with pentavalent3 vaccination (HR: 3.33; 95%CI: 1.71-6.47) and approached significance for measles (HR: 2.05; 95%CI: 0.95-4.41; p=0.07), as compared to controls. The SMS only and SMS plus 75KSH were not significantly associated with either vaccine. Conclusions: In a population with moderate phone ownership, high immunization coverage, and moderate vaccine delays, SMS reminders plus 200KSH improved pentavalent3 vaccination. Advisors/Committee Members: Moss, William (advisor).

Subjects/Keywords: vaccines; mHealth

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APA (6^th Edition):

Gibson, D. (2014). The readiness, need for, and effect of mhealth interventions to improve immunization timeliness and coverage in rural western Kenya. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gibson, Dustin. “The readiness, need for, and effect of mhealth interventions to improve immunization timeliness and coverage in rural western Kenya.” 2014. Thesis, Johns Hopkins University. Accessed January 15, 2021. http://jhir.library.jhu.edu/handle/1774.2/37995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gibson, Dustin. “The readiness, need for, and effect of mhealth interventions to improve immunization timeliness and coverage in rural western Kenya.” 2014. Web. 15 Jan 2021.

Vancouver:

Gibson D. The readiness, need for, and effect of mhealth interventions to improve immunization timeliness and coverage in rural western Kenya. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Jan 15]. Available from: http://jhir.library.jhu.edu/handle/1774.2/37995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gibson D. The readiness, need for, and effect of mhealth interventions to improve immunization timeliness and coverage in rural western Kenya. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/37995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Simbaya, Joseph. Evaluation of the Antiretroviral Community education and referral (ACER) project - Ng'ombe project site.

Degree: 2011, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/638

► In Zambia, the prevalence of HIV is estimated to be 16% among individuals 15-49 years old. Among 15-24 year olds, women (12.7%) are four times… (more)

▼ In Zambia, the prevalence of HIV is estimated to be 16% among individuals 15-49 years old. Among 15-24 year olds, women (12.7%) are four times more likely to be infected by HIV than men (3.8%) (ZDHS, 2002).The Antiretroviral Community Education and Referral (ACER) project was conceptually designed on the basis of the findings from the community consultations, to improve health seeking behaviour, equity of access, adherence to Anti-Retroviral Treatment, prevention for people living with HIV and how to decrease stigma and discrimination.This evaluation assesses the role of the project in supporting access and adherence to ART so as to recommend ways of enhancing community access and adherence to ART.The specific objectives are: (i) To assess the adequacy of project design and implementation strategies and the extent to which gender issues were taken into consideration; (ii) To assess the contribution of the ACER project to the people's access and adherence to ART and recommend ways of enhancing community access and adherence to ART. The researcher questions are: (i) Were the project design and strategies adequate to take into account gender dimensions of ART access and adherence? (ii) What has been the contribution of the ACER project to community access and adherence to ART and how could it be enhanced and sustained? The first strength of the project has been the development of partnerships between organisations in the communities which has extended the reach of the project.However, specific strategies aimed at closing the gender gap in HIV infection and ART access were not included in the design of the project. The project put more emphasis on mobilising people for ART without adequate strategies aimed at prevention of infection, especially among women. The other strengthen in the design has been the involvement of people living with HIV/AIDS (PLWHA). The study findings suggest that stigma has reduced, indicated by the increase in the number of people seeking VCT services and those joining support groups and a reduction in incidents of experienced stigma. The study has recorded an increase in the number of people on ART from 11 to over 400 people over a 2 year period. Adherence data from the project shows high levels of selfreported adherence (about 99%). The potential for the activities to be sustainable are high-Based on the findings, it is recommended: (i) that a strategy must be developed to ensure that uptake for testing and ART is improved among men. (ii) that targeted efforts aimed at reducing infection levels among women must be adopted (iii) that the project must mainstream gender into all project activities.

Subjects/Keywords: AIDS vaccines

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APA (6^th Edition):

Simbaya, J. (2011). Evaluation of the Antiretroviral Community education and referral (ACER) project - Ng'ombe project site. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/638

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Simbaya, Joseph. “Evaluation of the Antiretroviral Community education and referral (ACER) project - Ng'ombe project site.” 2011. Thesis, University of Zimbabwe. Accessed January 15, 2021. http://dspace.unza.zm/handle/123456789/638.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Simbaya, Joseph. “Evaluation of the Antiretroviral Community education and referral (ACER) project - Ng'ombe project site.” 2011. Web. 15 Jan 2021.

Vancouver:

Simbaya J. Evaluation of the Antiretroviral Community education and referral (ACER) project - Ng'ombe project site. [Internet] [Thesis]. University of Zimbabwe; 2011. [cited 2021 Jan 15]. Available from: http://dspace.unza.zm/handle/123456789/638.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Simbaya J. Evaluation of the Antiretroviral Community education and referral (ACER) project - Ng'ombe project site. [Thesis]. University of Zimbabwe; 2011. Available from: http://dspace.unza.zm/handle/123456789/638

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

4. Mohler, Virginia (Jennie) Lea. Efficacy of DNA Adenine Methylase Salmonella Vaccines in Livestock .

Degree: 2011, University of Sydney

URL: http://hdl.handle.net/2123/8782

► Intensive livestock production and management systems are associated with increased faecal-oral pathogen transmission which can contribute to a high prevalence of multiple Salmonella serovars in… (more)

▼ Intensive livestock production and management systems are associated with increased faecal-oral pathogen transmission which can contribute to a high prevalence of multiple Salmonella serovars in large dairy farms and feedlots. Outbreaks of salmonellosis in livestock often reflect a series of events that compromise host immunity and increase pathogen exposure. High risk groups in cattle include neonates and post partum cows (Anderson, et al., 2001; House, et al., 2001a; Fossler, et al., 2005a) and variation in susceptibility to salmonella infection has been observed in sheep entering feedlots according to property of origin, body condition, and time of year (Norris, et al., 1989a; Norris, et al., 1989b; Richards and Hyder, 1991; Kelly, 1995; Makin, 2011). The associated increase in the incidence of disease and contamination of livestock-derived food products imposes a significant risk to food safety via consumption of contaminated meat, milk, eggs and vegetables. The development and application of effective Salmonella vaccines offers a potential means of reducing industry associated losses and public health risks. Effective Salmonella vaccination therefore requires induction of protection against several Salmonella serovars and stimulation of both innate and acquired immune mechanisms. Vaccine prophylaxis is normally achieved through vaccinating animals several weeks prior to virulent pathogen exposure. This is not possible in neonates where exposure occurs at birth and in feedlots where livestock are sourced from diverse locations and vendors. Additionally, direct physical handling of livestock to administer vaccines contributes to stress and may lead to carcass damage. Conducting stressful procedures at feedlot induction when there is concurrent exposure to a diversity of pathogens contributes to an increased risk of disease. iii Traditional vaccination methods are labour intensive and associated with carcass damage and adverse reactions. Oral delivery of vaccines and medications via drinking water is a common practice in intensively managed poultry. Oral vaccine delivery via drinking water avoids the stress of additional handling and provides a means of rapidly vaccinating large numbers of animals. The efficacy of Salmonella vaccination is largely influenced by the diversity of Salmonella serovars encountered and the interval between immunisation and pathogen exposure, which may be short in field settings, e.g., following birth, during transport and following introduction into feedlots. The timing of virulent pathogen exposure may also have an impact on the safety of a Salmonella vaccine. It is imperative to develop livestock vaccines that are capable of safely eliciting potent states of cross-protective immunity against a diversity of serovars. This thesis examines the capacity of the dam S. Typhimurium vaccine (serogroup B) to elicit cross-protection against a virulent challenge in models of neonate and adult ruminant models of salmonellosis, as well as investigating in-water vaccine delivery. Cross-protective…

Subjects/Keywords: Livestock; Vaccines

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APA (6^th Edition):

Mohler, V. (. L. (2011). Efficacy of DNA Adenine Methylase Salmonella Vaccines in Livestock . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/8782

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mohler, Virginia (Jennie) Lea. “Efficacy of DNA Adenine Methylase Salmonella Vaccines in Livestock .” 2011. Thesis, University of Sydney. Accessed January 15, 2021. http://hdl.handle.net/2123/8782.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mohler, Virginia (Jennie) Lea. “Efficacy of DNA Adenine Methylase Salmonella Vaccines in Livestock .” 2011. Web. 15 Jan 2021.

Vancouver:

Mohler V(L. Efficacy of DNA Adenine Methylase Salmonella Vaccines in Livestock . [Internet] [Thesis]. University of Sydney; 2011. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2123/8782.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mohler V(L. Efficacy of DNA Adenine Methylase Salmonella Vaccines in Livestock . [Thesis]. University of Sydney; 2011. Available from: http://hdl.handle.net/2123/8782

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Wisconsin – Oshkosh

5. Weiss, Emily M. What are parents' perceptions of the HPV vaccine for their adolescent sons?.

Degree: MSin Nursing, Family Nurse Practitioner., 2011, University of Wisconsin – Oshkosh

URL: http://digital.library.wisc.edu/1793/53384

►

A Clinical paper submitted in partial fulfillment of the requirements for the degree of Master of Science in Nursing - Family Nurse Practitioner.

Human Papillomavirus… (more)

Subjects/Keywords: Vaccines - Health aspects; Parents - Attitudes; Papillomavirus vaccines

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APA (6^th Edition):

Weiss, E. M. (2011). What are parents' perceptions of the HPV vaccine for their adolescent sons?. (Masters Thesis). University of Wisconsin – Oshkosh. Retrieved from http://digital.library.wisc.edu/1793/53384

Chicago Manual of Style (16^th Edition):

Weiss, Emily M. “What are parents' perceptions of the HPV vaccine for their adolescent sons?.” 2011. Masters Thesis, University of Wisconsin – Oshkosh. Accessed January 15, 2021. http://digital.library.wisc.edu/1793/53384.

MLA Handbook (7^th Edition):

Weiss, Emily M. “What are parents' perceptions of the HPV vaccine for their adolescent sons?.” 2011. Web. 15 Jan 2021.

Vancouver:

Weiss EM. What are parents' perceptions of the HPV vaccine for their adolescent sons?. [Internet] [Masters thesis]. University of Wisconsin – Oshkosh; 2011. [cited 2021 Jan 15]. Available from: http://digital.library.wisc.edu/1793/53384.

Council of Science Editors:

Weiss EM. What are parents' perceptions of the HPV vaccine for their adolescent sons?. [Masters Thesis]. University of Wisconsin – Oshkosh; 2011. Available from: http://digital.library.wisc.edu/1793/53384

University of Toledo

6. Sarkar, Sourav. SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES.

Degree: PhD, Chemistry, 2012, University of Toledo

URL: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1345008057

► The inherent weak immune response against carbohydrate antigens has directed several novel approaches towards increasing their immunogenicity for their use as vaccine components. We… (more)

▼ The inherent weak immune response against carbohydrate antigens has directed several novel approaches towards increasing their immunogenicity for their use as vaccine components. We hypothesized that conjugation of an L-rhamnose (Rha) moiety to a carbohydrate antigen would increase the immune response against the antigen in mice possessing anti-Rha antibodies via an antibody-dependent antigen uptake mechanism. To explore this hypothesis we synthesized a single-molecule three-component vaccine containing the GalNAc-O-Thr (Tn) tumor specific antigen, a 20 amino acid helper T-cell epitope (YAF) derived from an outer membrane protein of Neisseria meningitides and a Rha moiety. Synthesis of the vaccine was achieved by automated Fmoc-based solid phase peptide synthesis and deacetylated by brief treatment with NaOMe. Groups of female BALB/c mice were immunized and boosted with Rha-ovalbumin (Rha-OVA) formulated with either TiterMax¿¿ Gold or Sigma Adjuvant System¿¿ for a period of 35 days to generate optimum anti-Rha antibodies necessary for evaluating the vaccine. Anti-Rha antibody titers were >100 fold higher in groups of mice immunized with Rha-OVA than the control groups. Mice producing anti-Rha were challenged with Rha-YAF-Tn or YAF-Tn. Sera collected from the groups initially immunized with Rha-OVA and later challenged with Rha-YAF-Tn showed a two fold increase in anti-Tn titer at 1/100 serum dilution compared to mice not immunized with Rha-OVA. An in vitro T-cell proliferation study using cells primed with either Rha-YAF-Tn or YAF-Tn was performed to examine differences in antigen uptake and presentation on the MHC II in the presence of anti-Rha antibodies. In the presense of anti-Rha antibodies proliferation of T-cells showed a 10-fold decrease in the amount of antigen required. The result strongly suggests that T-cells present in the spleen were presented with higher concentrations of Rha-YAF-Tn as a result of the presence of the anti-Rha antibodies. MUC1 variable number tandem repeats (VNTRs) conjugated to tumor-associated carbohydrate antigens (TACAs) have been shown to break self-tolerance in humanized MUC1 transgenic mice. Therefore, we hypothesize that a MUC1 VNTR TACA-conjugate can be successfully formulated into a liposome-based anti-cancer vaccine. The immunogenicity of the vaccine should be further augmented by incorporating surface displayed L-rhamnose (Rha) epitopes onto the liposomes to take advantage of a natural antibody-dependent antigen uptake mechanism. To validate our hypothesis we synthesized a 20-amino acid MUC1 glycopeptide containing a GalNAc-O-Thr (Tn) TACA by SPPS and conjugated it to a functionalized Toll-like receptor ligand (TLRL). An L-Rha-cholesterol conjugate was prepared using tetraethylene glycol (TEG) as a linker. The liposome-based anti-cancer vaccine was formulated by the extrusion method using TLRL-MUC1-Tn conjugate, Rha-TEG-cholesterol and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in a total lipid concentration of 30 mM. The stability, homogeneity and size… Advisors/Committee Members: Sucheck, Steven (Committee Chair).

Subjects/Keywords: Chemistry; anti-cancer vaccines; anti-tumor vaccines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sarkar, S. (2012). SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES. (Doctoral Dissertation). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1345008057

Chicago Manual of Style (16^th Edition):

Sarkar, Sourav. “SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES.” 2012. Doctoral Dissertation, University of Toledo. Accessed January 15, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1345008057.

MLA Handbook (7^th Edition):

Sarkar, Sourav. “SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES.” 2012. Web. 15 Jan 2021.

Vancouver:

Sarkar S. SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES. [Internet] [Doctoral dissertation]. University of Toledo; 2012. [cited 2021 Jan 15]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1345008057.

Council of Science Editors:

Sarkar S. SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES. [Doctoral Dissertation]. University of Toledo; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1345008057

Drexel University

7. Mullassery, Daisy George. Effect of Health Beliefs and Acculturation on HPV Vaccine Acceptance among Asian Indian Parents.

Degree: 2016, Drexel University

URL: http://hdl.handle.net/1860/idea:6686

► Background: Asian Indians are considered the third largest Asian community in the United States numbering 3.2 million per records from the U.S. census bureau for… (more)

▼ Background: Asian Indians are considered the third largest Asian community in the United States numbering 3.2 million per records from the U.S. census bureau for the year 2010, but little is known about Asian Indian parents' acceptance of the HPV vaccine for their children. Human Papillomavirus (HPV) is the most common sexually transmitted disease in the United States. Even though HPV vaccination is highly effective in preventing HPV infection, many studies have proposed that the vaccination rates in general are low. According to the teen vaccination coverage report by Center for Disease Control in 2014, only 37.6% of girls and 13.9% of boys between the age group of 13 - 17 years received all three doses of HPV vaccination. The key determinant of HPV vaccination rates is parental acceptance. The major factors affecting parental acceptance of HPV vaccination include health beliefs, educational level, religion, child's gender, subjective norms, (peer, family, and social pressure), and personal experience of the disease. While there are several studies in the U.S that have examined parental acceptance of HPV vaccination in general, to date there were no studies specifically focusing on Asian Indian parents living in the U.S, nor any that had assessed the effects of acculturation (cultural identity) on HPV acceptance in the commonly available databases. Therefore, because the factors affecting HPV vaccination acceptance of Asian Indian parents are unknown, the purpose of this study was to determine the effects of health beliefs (perceived seriousness, perceived susceptibility, perceived barriers, perceived benefits) and acculturation (cultural identity) and to explore the effects of educational level, religion, child's gender, subjective norms, and personal experience of the disease on Asian Indian parental acceptance of the HPV vaccine. Methods: A comparative descriptive cross-sectional design based on a theoretical framework of Health Belief Model was used for the study. The sample, Asian Indian parents, who have children between the ages of 9-16 years, were recruited from various places of worship and community organizations from the Houston Metropolitan area and all over the U.S. Participants were recruited directly, with the help of formal and informal leaders of these organizations and through email. Participants were provided with a web-link for the research survey to assess the effect of health beliefs, acculturation, and demographic factors on HPV vaccine acceptance. As established by previous research on non-Asian Indian parents, the acceptance of at least one dose of HPV vaccination was expected to be 45% and the acceptance of Hepatitis B vaccination to be 90%. Using the above estimates, a sample size of 160 participants was deemed sufficient to achieve 81% power to detect a difference between group proportions of 0.45 with a significance level (alpha) of 0.05 using a two-sided two dependent group McNemar test. The same sample size is sufficient for hierarchical logistic regression analysis to achieve 81%… Advisors/Committee Members: Posmontier, Barbara, College of Nursing and Health Professions.

Subjects/Keywords: Nursing; Papillomavirus vaccines

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APA (6^th Edition):

Mullassery, D. G. (2016). Effect of Health Beliefs and Acculturation on HPV Vaccine Acceptance among Asian Indian Parents. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:6686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mullassery, Daisy George. “Effect of Health Beliefs and Acculturation on HPV Vaccine Acceptance among Asian Indian Parents.” 2016. Thesis, Drexel University. Accessed January 15, 2021. http://hdl.handle.net/1860/idea:6686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mullassery, Daisy George. “Effect of Health Beliefs and Acculturation on HPV Vaccine Acceptance among Asian Indian Parents.” 2016. Web. 15 Jan 2021.

Vancouver:

Mullassery DG. Effect of Health Beliefs and Acculturation on HPV Vaccine Acceptance among Asian Indian Parents. [Internet] [Thesis]. Drexel University; 2016. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1860/idea:6686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mullassery DG. Effect of Health Beliefs and Acculturation on HPV Vaccine Acceptance among Asian Indian Parents. [Thesis]. Drexel University; 2016. Available from: http://hdl.handle.net/1860/idea:6686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia State University

8. Mohammed, Anaam F. Assessment of Rotavirus Vaccine Type and Number of Doses on Severity of Disease.

Degree: MPH, 2013, Georgia State University

URL: https://scholarworks.gsu.edu/iph_theses/258

► Background: Rotavirus disease is the leading global cause of severe diarrhea in children under 5 years. We examined the association between different rotavirus vaccines… (more)

Subjects/Keywords: rotavirus; vaccines; immunizations

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APA (6^th Edition):

Mohammed, A. F. (2013). Assessment of Rotavirus Vaccine Type and Number of Doses on Severity of Disease. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/258

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mohammed, Anaam F. “Assessment of Rotavirus Vaccine Type and Number of Doses on Severity of Disease.” 2013. Thesis, Georgia State University. Accessed January 15, 2021. https://scholarworks.gsu.edu/iph_theses/258.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mohammed, Anaam F. “Assessment of Rotavirus Vaccine Type and Number of Doses on Severity of Disease.” 2013. Web. 15 Jan 2021.

Vancouver:

Mohammed AF. Assessment of Rotavirus Vaccine Type and Number of Doses on Severity of Disease. [Internet] [Thesis]. Georgia State University; 2013. [cited 2021 Jan 15]. Available from: https://scholarworks.gsu.edu/iph_theses/258.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mohammed AF. Assessment of Rotavirus Vaccine Type and Number of Doses on Severity of Disease. [Thesis]. Georgia State University; 2013. Available from: https://scholarworks.gsu.edu/iph_theses/258

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

RMIT University

9. Jayaraj, R. Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials.

Degree: 2008, RMIT University

URL: http://researchbank.rmit.edu.au/view/rmit:6708

► The liver flukes Fasciola hepatica and F. gigantica cause infectious disease in ruminants and humans. The geographical range of these two parasite species (temperate and… (more)

▼ The liver flukes Fasciola hepatica and F. gigantica cause infectious disease in ruminants and humans. The geographical range of these two parasite species (temperate and tropical respectively) ensures that infection can occur worldwide. Although anthelmintic treatment is effective against disease, emerging drug resistant strains leads to the development of a vaccine. However, despite several decades of research, there is no commercial vaccine available. The main challenge at present is to produce recombinant proteins in an immunologically active form using recombinant DNA technology. This is an essential step in Fasciola vaccine production. Cysteine proteases are probably the most important facilitators of virulence in flukes and are produced by all stages of the fluke life-cycle. Two classes of cysteine protease are found in the excretory and secretory material of liver flukes- these are cathepsin L and cathepsin B. As such, the major aims of this thesis were to investigate the expression and purification of Fasciola recombinant cysteine proteins, and characterisation by SDS-PAGE and immunoblotting using monoclonal and polyclonal antibodies. These studies demonstrate the production of functionally active cathepsin proteins in S. cerevisiae BJ3505 cells which will lead to vaccine candidate analysis. The second aim of this thesis was to determine the protective efficacy of stage specific target antigens against experimental infection. In addressing this issue, the protective efficacy of single and multivalent recombinant protein vaccinations of adult stage F. hepatica cathepsin L5, immature F. gigantica cathepsin L1g and juvenile F. hepatica cathepsin B were analysed in Sprague Dawley rats against F. hepatica infection. This study demonstrates that juvenile fluke target antigen-cathepsin B induces better immune protection than adult fluke antigen-cathepsin L5. Cocktails of juvenile and adult stage fluke recombinant proteins (cathepsin B and L5) elicited the highest protective immunity against experimental infection and this combination showed not only reduction in fluke recovery and size of flukes, but also marked diminution in the intensity of liver lesions in vaccinated rats. In order to assess the immunogenic property of an early infective stage fluke secreting cysteine protease as a vaccine candidate, DNA vaccination vectors encoding cathepsin B were analysed in BALB/c mice. In this study, the ability of four DNA vaccination strategies such as secretory, chemokine-activating, lymph node targeting vectors encoding cathepsin B were assessed by antibody titre, antibody avidity, western blotting and ELIPSOT assay. The results have further validated the immunoprophylactic potential of a cathepsin B vaccine against F. hepatica. In this study, we have expressed and attained high yields of F. gigantica cathepsin L1g from E. coli BL21, and compared this to a yeast-expressed system. This protease was over-expressed and formed insoluble inclusion bodies that were subsequently solubilised with urea or guanidine…

Subjects/Keywords: Fields of Research; Fasciola; Vaccines

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APA (6^th Edition):

Jayaraj, R. (2008). Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:6708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jayaraj, R. “Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials.” 2008. Thesis, RMIT University. Accessed January 15, 2021. http://researchbank.rmit.edu.au/view/rmit:6708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jayaraj, R. “Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials.” 2008. Web. 15 Jan 2021.

Vancouver:

Jayaraj R. Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials. [Internet] [Thesis]. RMIT University; 2008. [cited 2021 Jan 15]. Available from: http://researchbank.rmit.edu.au/view/rmit:6708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jayaraj R. Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials. [Thesis]. RMIT University; 2008. Available from: http://researchbank.rmit.edu.au/view/rmit:6708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

10. Shonga, Chiwambo Rhoza. Cost-effective analysis of highly active anti-retroviral treatment (HAART) at Choma General Hospital Art Center in Choma District .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/1866

► The study was conducted in order to estimate the costs and effects of ARVs used in treatment of HIV infected patients, to describe the costs… (more)

▼ The study was conducted in order to estimate the costs and effects of ARVs used in treatment of HIV infected patients, to describe the costs of prophylaxis and treating of opportunistic infections by use of No-ARVs and to determine the incremental cost-effectiveness ratio of No-ART and ART. A cost-effectiveness analysis was conducted from a public health perspective, comparing No- ART with ART intervention. This was a retrospective study done on a cohort of 207 using a pre-ART and ART study design on a five year period observation time (2004 – 2008). The cohort was aged 15 years and above with HIV infection disability and were selected by simple random technique of their records’ files. By the year 2006, with the adult HIV/AIDS prevalence rate of 16% in Zambia, Choma district had a high incidence rate of sexually transmitted infection (STIs) of 15.0 per 1000 population. The HIV infection was at incidence rate of 7.1 per 1000 population and case fatality rate of 195.1 per 1000 admissions and this revealed the high demand of antiretroviral drugs (ARVs) (Choma HMIS, 2006).The cohort simulation approach used was based on cost-effectiveness Markov Modeling in order to calculate life time costs, life years gained and health effects of ART versus No-ART. The study setting was in a public sector health facility at Choma ART centre. Data was collected using file check list, semi-structured interview schedule and discussion with the key informants who had more than five years experience of managing patients with HIV infections at Choma general hospital. Data analysis was done using Cost Model template (WHO CostIt Model) and Excel spread-sheet. The study results revealed that the transition probabilities of patients moving from stage 1 – 4 in No-ART was 0.24917 and in ART it was 0.1239. Transition probabilities of moving from 1 to death in No-ART was higher, 0.0678 and in ART it was only 0.0125. In both ART and No-ART cohort, the health status rating patients in stage 1 had a high utility rating of 0.85. In stage 4 the utility rating was 0.28. The lifetime costs of No-ART were 10,166,199 and for ART, 12,226,813. The costs per life year gained with No-ART were 1,166 and ART were 1,223. The health effects quality-adjusted life years (QALYs) for No-ART were 3,381 and ART, 6.073. The incremental cost-effectiveness ratio was 765.45. The life years lived with No-ART were 3.25 and with ART were 8.50. In conclusion, HAART intervention is reasonably cost-effective for HIV-infected patients in Zambia because the intervention reduces the costs of medical care of HIV disease and the incidences of opportunistic infections. This leads to a corresponding reduction in in-patient health care utilization. Results of cost-effectiveness analysis in this study could assist in enhancing efficient resource allocation and equitable access to HIV treatment.

Subjects/Keywords: AIDS Vaccines; AIDS(Disease) Prevention

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APA (6^th Edition):

Shonga, C. R. (2012). Cost-effective analysis of highly active anti-retroviral treatment (HAART) at Choma General Hospital Art Center in Choma District . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shonga, Chiwambo Rhoza. “Cost-effective analysis of highly active anti-retroviral treatment (HAART) at Choma General Hospital Art Center in Choma District .” 2012. Thesis, University of Zambia. Accessed January 15, 2021. http://hdl.handle.net/123456789/1866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shonga, Chiwambo Rhoza. “Cost-effective analysis of highly active anti-retroviral treatment (HAART) at Choma General Hospital Art Center in Choma District .” 2012. Web. 15 Jan 2021.

Vancouver:

Shonga CR. Cost-effective analysis of highly active anti-retroviral treatment (HAART) at Choma General Hospital Art Center in Choma District . [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/123456789/1866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shonga CR. Cost-effective analysis of highly active anti-retroviral treatment (HAART) at Choma General Hospital Art Center in Choma District . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

11. Mweemba, Ngalande Zondiwe. Factors associated with cotrimoxazole compliance among HIV exposed infants at chikankata mission hospital, chikankata districts, Southern Province .

Degree: 2015, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4366

► Compliance to cotrimoxazole by HIV exposed infants can save lives of many HIV exposed infants. The general objective of the study was to determine factors… (more)

▼ Compliance to cotrimoxazole by HIV exposed infants can save lives of many HIV exposed infants. The general objective of the study was to determine factors associated with cotrimoxazole prophylaxis compliance by HIV exposed infants. The study was conducted at chikankata Mission hospital catchment area in Chikankata district. A cross sectional study design was used and a total of 102 mothers /caretakers of HIV exposed infants aged 4 weeks to 18 months were selected using multistage sampling method. The mothers/caretakers of HIV exposed infants were interviewed using a structured interview schedule. Data collection was done in September to November 2014 using a pretested questionnaire. Questions that were asked generated demographic information about mother /caretakers; compliance to cotrimoxazole prophylaxis, mothers /caretakers knowledge about the benefits of cotrimoxazole .prophylaxis, service and socio cultural factors influencing mothers/caretakers compliance with cotrimoxazole prophylaxis. SPSS statistical package was used for data entering and analysis Descriptive statistics were employed to illustrate the data and chi-square test was used to test associations among variables. The p values of less than 0.05 were considered statistically significant. The findings showed that 78.7% of the respondents were non compliant with cotrimoxazole prophylaxis, 95% had heard about cotrimoxazole prophylaxis and their source of information was the health worker (98%). Sixty percent (60%) of the respondents knew the use of cotrimoxazole prophylaxis, 51% knew the benefits of cotrimoxazole prophylaxis. About 75.5% of the respondents stated that cotrimoxazole was not available at the health facilities, 89.2% stated that the road between their respective homes and the nearest health facility was passable, 73% said that the health workers at their nearest health facility did not encourage them to collect the drug when it ran out and 53.9% said that nurses at the nearest health facility did not follow them up when they did not go back for resupply of the drug. Seventy seven and half percent (77.5%) of the respondents stated that their spouses did not allow them to collect cotrimoxazole when it ran out, 89.2% reported that their spouses knew about their HIV status and 65.7% said that they felt free to give their child cotrimoxazole in public. About sixty one point eight percent (61.8%) of the respondents did not know that there was a social support group for mothers/caretakers of HIV exposed infants in their community and 74.5% stated that there were misconceptions about cotrimoxazole in the communities where they live. The study showed a significant association between compliance to cotrimoxazole prophylaxis and the following factors: non availability of drugs (P=<0.0001), attitude of the health care providers at nearest health facility (P=<0.001), lack of follow up (P=0.009), and impassable roads (P=0.026) as service related factor. There was also a significant association between compliance to…

Subjects/Keywords: HIV antibiotics; AIDS Vaccines – Zambia

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APA (6^th Edition):

Mweemba, N. Z. (2015). Factors associated with cotrimoxazole compliance among HIV exposed infants at chikankata mission hospital, chikankata districts, Southern Province . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4366

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mweemba, Ngalande Zondiwe. “Factors associated with cotrimoxazole compliance among HIV exposed infants at chikankata mission hospital, chikankata districts, Southern Province .” 2015. Thesis, University of Zambia. Accessed January 15, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4366.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mweemba, Ngalande Zondiwe. “Factors associated with cotrimoxazole compliance among HIV exposed infants at chikankata mission hospital, chikankata districts, Southern Province .” 2015. Web. 15 Jan 2021.

Vancouver:

Mweemba NZ. Factors associated with cotrimoxazole compliance among HIV exposed infants at chikankata mission hospital, chikankata districts, Southern Province . [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Jan 15]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4366.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mweemba NZ. Factors associated with cotrimoxazole compliance among HIV exposed infants at chikankata mission hospital, chikankata districts, Southern Province . [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4366

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

12. Misset, J. Mucosal immunity of the female genital tract after HPV infection and vaccination.

Degree: 2013, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/273276

► Human papillomavirus is one of the most common sexually transmitted pathogens. HPV infections are associated with the development of cervical cancer, other genital cancers and… (more)

Subjects/Keywords: HPV; mucosal; vaccines; papillomavirus

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APA (6^th Edition):

Misset, J. (2013). Mucosal immunity of the female genital tract after HPV infection and vaccination. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/273276

Chicago Manual of Style (16^th Edition):

Misset, J. “Mucosal immunity of the female genital tract after HPV infection and vaccination.” 2013. Masters Thesis, Universiteit Utrecht. Accessed January 15, 2021. http://dspace.library.uu.nl:8080/handle/1874/273276.

MLA Handbook (7^th Edition):

Misset, J. “Mucosal immunity of the female genital tract after HPV infection and vaccination.” 2013. Web. 15 Jan 2021.

Vancouver:

Misset J. Mucosal immunity of the female genital tract after HPV infection and vaccination. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Jan 15]. Available from: http://dspace.library.uu.nl:8080/handle/1874/273276.

Council of Science Editors:

Misset J. Mucosal immunity of the female genital tract after HPV infection and vaccination. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/273276

Universiteit Utrecht

13. Ven, G.F.A. van de. The use of autogenous vaccines in the Dutch pig industry and suggestions for new legislation of autogenous vaccines.

Degree: 2013, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/287206

► The aim of this study was to make an inventory of the total production and use of autogenous vaccines in the Dutch pig industry in… (more)

Subjects/Keywords: Autogenous vaccines; Pig; legislation; inventory

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APA (6^th Edition):

Ven, G. F. A. v. d. (2013). The use of autogenous vaccines in the Dutch pig industry and suggestions for new legislation of autogenous vaccines. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/287206

Chicago Manual of Style (16^th Edition):

Ven, G F A van de. “The use of autogenous vaccines in the Dutch pig industry and suggestions for new legislation of autogenous vaccines.” 2013. Masters Thesis, Universiteit Utrecht. Accessed January 15, 2021. http://dspace.library.uu.nl:8080/handle/1874/287206.

MLA Handbook (7^th Edition):

Ven, G F A van de. “The use of autogenous vaccines in the Dutch pig industry and suggestions for new legislation of autogenous vaccines.” 2013. Web. 15 Jan 2021.

Vancouver:

Ven GFAvd. The use of autogenous vaccines in the Dutch pig industry and suggestions for new legislation of autogenous vaccines. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Jan 15]. Available from: http://dspace.library.uu.nl:8080/handle/1874/287206.

Council of Science Editors:

Ven GFAvd. The use of autogenous vaccines in the Dutch pig industry and suggestions for new legislation of autogenous vaccines. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/287206

University of Hong Kong

14. 張靄凝. Literature review of parental acceptability about HPV vaccine.

Degree: 2009, University of Hong Kong

URL: http://hdl.handle.net/10722/56914

Subjects/Keywords: Papillomavirus vaccines.

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APA (6^th Edition):

張靄凝.. (2009). Literature review of parental acceptability about HPV vaccine. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/56914

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

張靄凝.. “Literature review of parental acceptability about HPV vaccine.” 2009. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/56914.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

張靄凝.. “Literature review of parental acceptability about HPV vaccine.” 2009. Web. 15 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

張靄凝.. Literature review of parental acceptability about HPV vaccine. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/56914.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

張靄凝.. Literature review of parental acceptability about HPV vaccine. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/56914

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

15. Lee, Sze-tsai, Esther. A review of seasonal and pandemic influenza vaccine recommendations bydifferent countries.

Degree: 2010, University of Hong Kong

URL: http://hdl.handle.net/10722/132288

Subjects/Keywords: Influenza vaccines.

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APA (6^th Edition):

Lee, Sze-tsai, E. (2010). A review of seasonal and pandemic influenza vaccine recommendations bydifferent countries. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/132288

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Sze-tsai, Esther. “A review of seasonal and pandemic influenza vaccine recommendations bydifferent countries.” 2010. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/132288.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Sze-tsai, Esther. “A review of seasonal and pandemic influenza vaccine recommendations bydifferent countries.” 2010. Web. 15 Jan 2021.

Vancouver:

Lee, Sze-tsai E. A review of seasonal and pandemic influenza vaccine recommendations bydifferent countries. [Internet] [Thesis]. University of Hong Kong; 2010. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/132288.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee, Sze-tsai E. A review of seasonal and pandemic influenza vaccine recommendations bydifferent countries. [Thesis]. University of Hong Kong; 2010. Available from: http://hdl.handle.net/10722/132288

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

16. 吴秋阳. Exploring public-private partnerships in HIV/AIDS vaccine development: challenges and prospects.

Degree: 2010, University of Hong Kong

URL: http://hdl.handle.net/10722/132323

Subjects/Keywords: AIDS vaccines.

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APA (6^th Edition):

吴秋阳.. (2010). Exploring public-private partnerships in HIV/AIDS vaccine development: challenges and prospects. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/132323

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

吴秋阳.. “Exploring public-private partnerships in HIV/AIDS vaccine development: challenges and prospects.” 2010. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/132323.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

吴秋阳.. “Exploring public-private partnerships in HIV/AIDS vaccine development: challenges and prospects.” 2010. Web. 15 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

吴秋阳.. Exploring public-private partnerships in HIV/AIDS vaccine development: challenges and prospects. [Internet] [Thesis]. University of Hong Kong; 2010. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/132323.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

吴秋阳.. Exploring public-private partnerships in HIV/AIDS vaccine development: challenges and prospects. [Thesis]. University of Hong Kong; 2010. Available from: http://hdl.handle.net/10722/132323

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Rochester Institute of Technology

17. Yeiter, Joseph N. Vaccine Procurement in a Time-Indexed Model with Quantity-Based Discounts.

Degree: MS, Industrial and Systems Engineering, 2020, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/10458

► Vaccination is hailed as one of the greatest scientific achievements of the past century. However, affordability and accessibility prevent low-income countries from realizing the… (more)

Subjects/Keywords: Discount; Procurement; Time; Vaccines

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APA (6^th Edition):

Yeiter, J. N. (2020). Vaccine Procurement in a Time-Indexed Model with Quantity-Based Discounts. (Masters Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/10458

Chicago Manual of Style (16^th Edition):

Yeiter, Joseph N. “Vaccine Procurement in a Time-Indexed Model with Quantity-Based Discounts.” 2020. Masters Thesis, Rochester Institute of Technology. Accessed January 15, 2021. https://scholarworks.rit.edu/theses/10458.

MLA Handbook (7^th Edition):

Yeiter, Joseph N. “Vaccine Procurement in a Time-Indexed Model with Quantity-Based Discounts.” 2020. Web. 15 Jan 2021.

Vancouver:

Yeiter JN. Vaccine Procurement in a Time-Indexed Model with Quantity-Based Discounts. [Internet] [Masters thesis]. Rochester Institute of Technology; 2020. [cited 2021 Jan 15]. Available from: https://scholarworks.rit.edu/theses/10458.

Council of Science Editors:

Yeiter JN. Vaccine Procurement in a Time-Indexed Model with Quantity-Based Discounts. [Masters Thesis]. Rochester Institute of Technology; 2020. Available from: https://scholarworks.rit.edu/theses/10458

Oregon State University

18. Mannam, Praveen. Immune response and protection against Streptococcus pyogenes after vaccination with Lactococcus lactis that expresses conserved region of M6 protein.

Degree: MS, Microbiology, 2003, Oregon State University

URL: http://hdl.handle.net/1957/30816

► Most pathogens gain access to their host through mucosal surfaces. It is therefore desirable to develop mucosal vaccines that elicit an immune response to prevent… (more)

Subjects/Keywords: Bacterial vaccines

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APA (6^th Edition):

Mannam, P. (2003). Immune response and protection against Streptococcus pyogenes after vaccination with Lactococcus lactis that expresses conserved region of M6 protein. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/30816

Chicago Manual of Style (16^th Edition):

Mannam, Praveen. “Immune response and protection against Streptococcus pyogenes after vaccination with Lactococcus lactis that expresses conserved region of M6 protein.” 2003. Masters Thesis, Oregon State University. Accessed January 15, 2021. http://hdl.handle.net/1957/30816.

MLA Handbook (7^th Edition):

Mannam, Praveen. “Immune response and protection against Streptococcus pyogenes after vaccination with Lactococcus lactis that expresses conserved region of M6 protein.” 2003. Web. 15 Jan 2021.

Vancouver:

Mannam P. Immune response and protection against Streptococcus pyogenes after vaccination with Lactococcus lactis that expresses conserved region of M6 protein. [Internet] [Masters thesis]. Oregon State University; 2003. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1957/30816.

Council of Science Editors:

Mannam P. Immune response and protection against Streptococcus pyogenes after vaccination with Lactococcus lactis that expresses conserved region of M6 protein. [Masters Thesis]. Oregon State University; 2003. Available from: http://hdl.handle.net/1957/30816

Oregon State University

19. Simon, Benjamin E. Recombinant vaccines against infectious hematopoietic necrosis virus : bacterial systems for vaccine production and delivery.

Degree: PhD, Microbiology, 2001, Oregon State University

URL: http://hdl.handle.net/1957/32690

► Several systems were examined for the production and delivery of recombinant vaccines for fish. C. crescentus was employed to produce a fragment of the IHNV… (more)

Subjects/Keywords: Viral vaccines

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APA (6^th Edition):

Simon, B. E. (2001). Recombinant vaccines against infectious hematopoietic necrosis virus : bacterial systems for vaccine production and delivery. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/32690

Chicago Manual of Style (16^th Edition):

Simon, Benjamin E. “Recombinant vaccines against infectious hematopoietic necrosis virus : bacterial systems for vaccine production and delivery.” 2001. Doctoral Dissertation, Oregon State University. Accessed January 15, 2021. http://hdl.handle.net/1957/32690.

MLA Handbook (7^th Edition):

Simon, Benjamin E. “Recombinant vaccines against infectious hematopoietic necrosis virus : bacterial systems for vaccine production and delivery.” 2001. Web. 15 Jan 2021.

Vancouver:

Simon BE. Recombinant vaccines against infectious hematopoietic necrosis virus : bacterial systems for vaccine production and delivery. [Internet] [Doctoral dissertation]. Oregon State University; 2001. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1957/32690.

Council of Science Editors:

Simon BE. Recombinant vaccines against infectious hematopoietic necrosis virus : bacterial systems for vaccine production and delivery. [Doctoral Dissertation]. Oregon State University; 2001. Available from: http://hdl.handle.net/1957/32690

20. Anastasopoulou, Eleftheria. Ανοσοθεραπεία καρκίνου: ανοσολογικές παράμετροι ως βιολογικοί δείκτες ανταπόκρισης ασθενών με καρκίνο.

Degree: 2016, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/37627

► Identification of tumor associated antigens (TAAs) contributed to the development of the peptide cancer vaccines, as a novel therapeutic approach in cancer. Clinical trials have… (more)

▼ Identification of tumor associated antigens (TAAs) contributed to the development of the peptide cancer vaccines, as a novel therapeutic approach in cancer. Clinical trials have shown promising results, though to a limited number of patients. Important limitations involve the multifunctionality of the immune system along with its interaction with the tumor, as well as the inappropriate clinical design. As far as the immune system is concerned, new therapeutic strategies combine inhibition of immunosuppressive elements, which usually flourish in tumor microenvironment, along with boosting of antitumor immune responses. Understanding how the immune system interacts with the tumor, leads to the improvement of the applied therapeutic approaches. On the other hand, cancer vaccine trials have failed to accomplish significant clinical responses due to the erroneous clinical design. Patient selection, as well as, the determination of the appropriate primary endpoints and immunologic monitoring are essential to successfully evaluate cancer vaccines and bring them to clinical use. Patient selection is an important procedure, since it indicates patients that could benefit from a specific treatment, hence contributing to the avoidance of overtreatment. The aim of the present dissertation is to suggest possible prognostic/predictive biomarkers for patient selection, based on the results of two immunotherapeutic clinical protocols with the HER2 peptide vaccine AE37. The AE37 vaccine consists of the native HER2 peptide ΑΕ36 (HER2(776-790)) chemically linked to the Ii-key (LRMK), a modification that actually enhances antigen presentation. Previous repots have shown that AE37 vaccine is safe and well tolerated, capable of inducing both CD4+ and CD8+ cellular immune responses in patients with HER2+ prostate or breast cancer. Results from the phase I clinical trial in prostate cancer patients showed that the AE37 can induce HER2 specific immune responses that could be detected even 3 years after the last inoculations. Retrospective analyses in the same patients, showed that preexisting levels of HER2 immunity and TGFβ plasma levels before the first inoculation, might have a prognostic role in the immunologic as well as clinical response in patients vaccinated with the AE37 peptide vaccine. More specifically, increased levels of preexisting IFNγ immunity in response to the native peptide AE36, correlated with better immunological response to the AE37 vaccine and better overall survival. However, elevated levels of TGFβ, an immunosuppressive factor, correlated with lower immunological responses and worse overall survival. Beside this, the magnitude of the DTH reaction seems to positively correspond to both immunological and clinical response. Given the fact that HLA molecules are considered genetic restricted elements, that indicate T cellular antitumor immune responses, we investigated the expression of HLA-A*24 and HLA-DRB1*11, in the context novel biomarkers’ identification. Even though the above mentioned alleles are rather common…

Subjects/Keywords: Αντικαρκινικά εμβόλια; Cancer vaccines

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APA (6^th Edition):

Anastasopoulou, E. (2016). Ανοσοθεραπεία καρκίνου: ανοσολογικές παράμετροι ως βιολογικοί δείκτες ανταπόκρισης ασθενών με καρκίνο. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/37627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anastasopoulou, Eleftheria. “Ανοσοθεραπεία καρκίνου: ανοσολογικές παράμετροι ως βιολογικοί δείκτες ανταπόκρισης ασθενών με καρκίνο.” 2016. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 15, 2021. http://hdl.handle.net/10442/hedi/37627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anastasopoulou, Eleftheria. “Ανοσοθεραπεία καρκίνου: ανοσολογικές παράμετροι ως βιολογικοί δείκτες ανταπόκρισης ασθενών με καρκίνο.” 2016. Web. 15 Jan 2021.

Vancouver:

Anastasopoulou E. Ανοσοθεραπεία καρκίνου: ανοσολογικές παράμετροι ως βιολογικοί δείκτες ανταπόκρισης ασθενών με καρκίνο. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10442/hedi/37627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anastasopoulou E. Ανοσοθεραπεία καρκίνου: ανοσολογικές παράμετροι ως βιολογικοί δείκτες ανταπόκρισης ασθενών με καρκίνο. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. Available from: http://hdl.handle.net/10442/hedi/37627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

21. Garcia, Javier Shalin. Evaluation of Vaccines on the Prevalence of Salmonella and/or Campylobacter in Layer and Broiler Chickens.

Degree: MS, Poultry Science, 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151008

► The control of foodborne pathogens especially Salmonella and Campylobacter are of great concern to the commercial poultry industry. The control of these pathogens could be… (more)

Subjects/Keywords: Salmonella; Campylobacter; Vaccines; Poultry

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APA (6^th Edition):

Garcia, J. S. (2013). Evaluation of Vaccines on the Prevalence of Salmonella and/or Campylobacter in Layer and Broiler Chickens. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151008

Chicago Manual of Style (16^th Edition):

Garcia, Javier Shalin. “Evaluation of Vaccines on the Prevalence of Salmonella and/or Campylobacter in Layer and Broiler Chickens.” 2013. Masters Thesis, Texas A&M University. Accessed January 15, 2021. http://hdl.handle.net/1969.1/151008.

MLA Handbook (7^th Edition):

Garcia, Javier Shalin. “Evaluation of Vaccines on the Prevalence of Salmonella and/or Campylobacter in Layer and Broiler Chickens.” 2013. Web. 15 Jan 2021.

Vancouver:

Garcia JS. Evaluation of Vaccines on the Prevalence of Salmonella and/or Campylobacter in Layer and Broiler Chickens. [Internet] [Masters thesis]. Texas A&M University; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1969.1/151008.

Council of Science Editors:

Garcia JS. Evaluation of Vaccines on the Prevalence of Salmonella and/or Campylobacter in Layer and Broiler Chickens. [Masters Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151008

University of Saskatchewan

22. Cameron, Derek H. An Alternative to Vaccines? Nosodes and Their Effect on Vaccine Debates in English Canada.

Degree: 2020, University of Saskatchewan

URL: http://hdl.handle.net/10388/12810

► In the 1980s, vaccine hesitance created a market for vaccine alternatives in Canada. Challenges to medical authority, especially from feminists and environmentalists, meant that parents’… (more)

Subjects/Keywords: Media Studies; History of Vaccines

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APA (6^th Edition):

Cameron, D. H. (2020). An Alternative to Vaccines? Nosodes and Their Effect on Vaccine Debates in English Canada. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cameron, Derek H. “An Alternative to Vaccines? Nosodes and Their Effect on Vaccine Debates in English Canada.” 2020. Thesis, University of Saskatchewan. Accessed January 15, 2021. http://hdl.handle.net/10388/12810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cameron, Derek H. “An Alternative to Vaccines? Nosodes and Their Effect on Vaccine Debates in English Canada.” 2020. Web. 15 Jan 2021.

Vancouver:

Cameron DH. An Alternative to Vaccines? Nosodes and Their Effect on Vaccine Debates in English Canada. [Internet] [Thesis]. University of Saskatchewan; 2020. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10388/12810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cameron DH. An Alternative to Vaccines? Nosodes and Their Effect on Vaccine Debates in English Canada. [Thesis]. University of Saskatchewan; 2020. Available from: http://hdl.handle.net/10388/12810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Harvard University

23. Chang, Angela Y. Falling Short of Expectations: Improving Policy Design in Global Health.

Degree: Doctor of Science (SD), 2017, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066955

►

This dissertation is comprised of three studies that examine three global and national-level policies, and apply different quantitative analyses to improve the research base that… (more)

Subjects/Keywords: HIV; multimorbidity; vaccines; equity

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APA (6^th Edition):

Chang, A. Y. (2017). Falling Short of Expectations: Improving Policy Design in Global Health. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066955

Chicago Manual of Style (16^th Edition):

Chang, Angela Y. “Falling Short of Expectations: Improving Policy Design in Global Health.” 2017. Doctoral Dissertation, Harvard University. Accessed January 15, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066955.

MLA Handbook (7^th Edition):

Chang, Angela Y. “Falling Short of Expectations: Improving Policy Design in Global Health.” 2017. Web. 15 Jan 2021.

Vancouver:

Chang AY. Falling Short of Expectations: Improving Policy Design in Global Health. [Internet] [Doctoral dissertation]. Harvard University; 2017. [cited 2021 Jan 15]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066955.

Council of Science Editors:

Chang AY. Falling Short of Expectations: Improving Policy Design in Global Health. [Doctoral Dissertation]. Harvard University; 2017. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066955

University of Texas Southwestern Medical Center

24. Desmond, Angela. New Approaches to the Development of Peptoid Vaccines.

Degree: 2015, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1573

► The ideal prophylactic vaccine against a toxin or pathogen should elicit the production of broadly protective antibodies against conserved epitopes. However, the epitopes that elicit… (more)

▼ The ideal prophylactic vaccine against a toxin or pathogen should elicit the production of broadly protective antibodies against conserved epitopes. However, the epitopes that elicit these antibodies are often not immunodominant and even when they are, characterizing and synthesizing them can be difficult, particularly if they are conformational. The long-term goal of this work was to develop prophylactic vaccines that elicit such antibodies without epitope characterization. To develop such a vaccine platform, it was hypothesized that screening large one-bead-one-compound libraries of synthetic compounds with monoclonal antibodies that have already been shown to be broadly protective against a toxin or pathogen would allow the identification of mimetic B cell epitopes. For this platform, peptoids were chosen to construct one-bead-one-compound libraries. Peptoids are N-oligosubstituted glycines that resemble peptides but bear their side groups on backbone nitrogens instead of carbons. This renders them protease resistant and enormously diverse, since they are not restricted to the twenty standard amino acids. Furthermore, previous work had demonstrated that a monoclonal antibody could be used to screen libraries of peptoids. Moreover, while peptoids themselves were not immunogenic, the attachment of peptoids to carrier proteins using a linker elicited antibodies against the peptoid/linker. Such T-cell dependent antigens elicited high-affinity, class-switched antibodies. The goal of this dissertation research was to continue optimizing the magnetic and color-based assays by which peptoid vaccine candidates could be identified and to screen libraries with neutralizing monoclonal antibodies against West Nile virus and murine norovirus type 1. In addition, the immunogenicity of peptoids was further examined by designing a peptoid-carrier, using it to immunize rabbits, and demonstrating that anti-peptoid antibodies could be affinity-purified from the resulting antisera. This antibody was then used in further optimization of the magnetic screening assay to ensure that future screens will efficiently and specifically identify the best vaccine candidates. Advisors/Committee Members: Pfeiffer, Julie K., Vitetta, Ellen S., Levine, Beth, Niederkorn, Jerry Y., Ward, E. Sally.

Subjects/Keywords: Antibodies, Monoclonal; Peptoids; Vaccines

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APA (6^th Edition):

Desmond, A. (2015). New Approaches to the Development of Peptoid Vaccines. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Desmond, Angela. “New Approaches to the Development of Peptoid Vaccines.” 2015. Thesis, University of Texas Southwestern Medical Center. Accessed January 15, 2021. http://hdl.handle.net/2152.5/1573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Desmond, Angela. “New Approaches to the Development of Peptoid Vaccines.” 2015. Web. 15 Jan 2021.

Vancouver:

Desmond A. New Approaches to the Development of Peptoid Vaccines. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2152.5/1573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Desmond A. New Approaches to the Development of Peptoid Vaccines. [Thesis]. University of Texas Southwestern Medical Center; 2015. Available from: http://hdl.handle.net/2152.5/1573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

25. Case, Allison Carroll. A Novel Platform to Generate Synthetic Vaccine Candidates.

Degree: 2012, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/990

► Vaccination remains the optimal means to prevent infectious disease by inducing antibodies that confer protective immunity against the pathogen in question [1-3]. However, there remain… (more)

▼ Vaccination remains the optimal means to prevent infectious disease by inducing antibodies that confer protective immunity against the pathogen in question [1-3]. However, there remain viruses against which no effective vaccines exists including human immunodeficiency virus (HIV), West Nile Virus (WNV) and hepatitis C virus (HCV). These viruses and others evade the immune response by undergoing rapid mutations in immunodominant epitopes [4-6]. In addition, although they usually express conserved epitopes that are important for inducing neutralizing antibodies, in many cases these are not immunodominant. Traditional techniques in vaccine development have not been able to overcome these barriers for these and other viruses. Subunit and peptide vaccines are very safe but it is often difficult to identify the key epitopes needed to make them effective. New approaches to developing safe vaccines that induce broadly neutralizing antibodies are needed. Therefore, the long term goal of this project was to generate vaccine candidates for any virus for which a neutralizing antibody existed or could be made without prior knowledge of the protective epitope(s). Furthermore, we desired a way to administer these vaccine candidates safely and before exposure so as to induce neutralizing antibodies. To accomplish these goals, we began with the development of a platform to generate synthetic vaccine candidates. This platform consisted of 1) libraries of B cell epitopes or “shapes” prepared by displaying peptoid sequences on beads, 2) neutralizing monoclonal antibodies (MAbs) to select the peptoids that bound to the antibody’s antigen-combining site, and 3) protein G dynabeads (PGDs) and a magnet to bind and isolate antibody bound peptoid beads. Any sequences identified in the platform as potential B cell mimetics were further evaluated in two validation assays. The first consisted of a “color screening” assay to determine that the isolated on-bead peptoids were bound by antibody. The second confirmed that these peptoids would fail to be bound by antibody if an excess of the native antigen was added (i.e. that peptoid sequences were bound by the antibody’s binding sites). The major accomplishments to emerge from this study were 1) the creation of an optimized magnetic screening platform for the isolation of peptide B cell epitopes from an on-bead library, 2) a magnetic screening platform optimized for the isolation of peptoid B cell epitopes from a peptoid library, and 3) the identification of potential peptoid B cell epitope mimetics of FLAG peptide from a peptoid library using a MAb. Taken together, a sensitive, specific, and reproducible platform to identify vaccine candidates from a peptoid library was created. This platform is particularly important for viruses like HIV, HCV, and WNV where mutation makes foreknowledge of conserved, neutralizing epitopes difficult. Once sufficiently large and diverse libraries are created, the B cell epitope mimetics (vaccine candidates) identifiable by this platform will have… Advisors/Committee Members: Vitetta, Ellen S..

Subjects/Keywords: Vaccines; HIV; Immunodominant Epitopes

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APA (6^th Edition):

Case, A. C. (2012). A Novel Platform to Generate Synthetic Vaccine Candidates. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Case, Allison Carroll. “A Novel Platform to Generate Synthetic Vaccine Candidates.” 2012. Thesis, University of Texas Southwestern Medical Center. Accessed January 15, 2021. http://hdl.handle.net/2152.5/990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Case, Allison Carroll. “A Novel Platform to Generate Synthetic Vaccine Candidates.” 2012. Web. 15 Jan 2021.

Vancouver:

Case AC. A Novel Platform to Generate Synthetic Vaccine Candidates. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2012. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2152.5/990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Case AC. A Novel Platform to Generate Synthetic Vaccine Candidates. [Thesis]. University of Texas Southwestern Medical Center; 2012. Available from: http://hdl.handle.net/2152.5/990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College London (University of London)

26. Baxendale, Helen Elizabeth. Analysis of the molecular basis of the immune response to Streptococcus pneumoniae capsular polysaccharide.

Degree: PhD, 2001, University College London (University of London)

URL: https://discovery.ucl.ac.uk/id/eprint/10101264/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252064

► Streptococcus pneumoniae is a major cause of infection world wide, particularly in the very young and the elderly. Serotype specific anti-capsular antibodies are known to… (more)

▼ Streptococcus pneumoniae is a major cause of infection world wide, particularly in the very young and the elderly. Serotype specific anti-capsular antibodies are known to protect against infection. Studies of human antibodies specific for bacterial derived capsular polysaccharide antigens reveal these antibodies to be oligoclonal and of limited diversity. Relatively little is known of the molecular basis of the human immune response to pneumococcal polysaccharide. With new generation pneumococcal conjugate vaccines now becoming available a better understanding of the human immune response to Streptococcus pneumoniae is of increasing importance. This thesis describes an analysis of the immune response to two types of pneumococcal vaccine (plain polysaccharide and conjugate) in healthy adult volunteers. Using heterohybridoma technology to produce antigen specific monoclonal antibodies, the diversity of the immune response to pneumococcal polysaccharides was analysed and the molecular characteristics of the antibodies were correlated with in vitro functional activity. A high proportion of the hybridomas produced were isotype switched and highly mutated, inconsistent with their being derived from a primary immune response. Identical genes were used by a number of individuals to generate antibodies to a variety of serotypes and a common replacement mutation was identified in the CDR2 of two clones derived from different individuals and of different sero-specificity. Both ranked highly in the functional assays. Two of the hybridomas generated were isotype switch variants of the same clone and demonstrated marked differences in antibody avidity and opsonophagocytic activity. These data suggest that the antibody repertoire induced by pneumococcal vaccination in adults may be restricted in V gene use with common V genes and somatic mutations demonstrated to a variety of serotypes and shared between individuals. Mutation analysis demonstrates that the antibody repertoire of adult vaccinees may be dictated not by vaccine formulation but by immune history of each individual in whom priming for memory has already occurred.

Subjects/Keywords: 616; Vaccines

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APA (6^th Edition):

Baxendale, H. E. (2001). Analysis of the molecular basis of the immune response to Streptococcus pneumoniae capsular polysaccharide. (Doctoral Dissertation). University College London (University of London). Retrieved from https://discovery.ucl.ac.uk/id/eprint/10101264/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252064

Chicago Manual of Style (16^th Edition):

Baxendale, Helen Elizabeth. “Analysis of the molecular basis of the immune response to Streptococcus pneumoniae capsular polysaccharide.” 2001. Doctoral Dissertation, University College London (University of London). Accessed January 15, 2021. https://discovery.ucl.ac.uk/id/eprint/10101264/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252064.

MLA Handbook (7^th Edition):

Baxendale, Helen Elizabeth. “Analysis of the molecular basis of the immune response to Streptococcus pneumoniae capsular polysaccharide.” 2001. Web. 15 Jan 2021.

Vancouver:

Baxendale HE. Analysis of the molecular basis of the immune response to Streptococcus pneumoniae capsular polysaccharide. [Internet] [Doctoral dissertation]. University College London (University of London); 2001. [cited 2021 Jan 15]. Available from: https://discovery.ucl.ac.uk/id/eprint/10101264/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252064.

Council of Science Editors:

Baxendale HE. Analysis of the molecular basis of the immune response to Streptococcus pneumoniae capsular polysaccharide. [Doctoral Dissertation]. University College London (University of London); 2001. Available from: https://discovery.ucl.ac.uk/id/eprint/10101264/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252064

University of Oxford

27. Atcheson, Erwan. Prospects for enhancing malaria vaccine efficacy by combining pre-erythrocytic antigens.

Degree: PhD, 2017, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:6506c003-7065-4d48-b049-f5e9136443d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748790

► Malaria causes almost half a million deaths each year. Existing interventions will almost certainly not be enough to tackle this enormous public health problem on… (more)

▼ Malaria causes almost half a million deaths each year. Existing interventions will almost certainly not be enough to tackle this enormous public health problem on their own. An effective vaccine is urgently needed. The leading malaria vaccine, RTS,S, confers suboptimal protective efficacy, and in addition targets only Plasmodium falciparum and not the other major species of human malaria, P. vivax. This thesis investigates the potential of combining pre-erythrocytic malaria vaccines as a means of enhancing protective efficacy. A novel mathematical model was developed which expresses probability of protection as a function of vaccine-induced humoural and cellular responses. The model predicts that combining partially effective vaccines should result in more than additive improvements in protective efficacy. This was supported by an experiment combining Rv21, a P. vivax circumsporozoite virus-like particle, with viral vectored P. vivax TRAP, the two leading pre-erythrocytic malaria vaccine antigens; this combination raised protective efficacy from 50% and 0%, respectively, to 100% sterile protection. It was also found that antigenic interference, a reduction in anti-CSP titres when Rv21 and PvTRAP are combined, occurred only in the presence of Matrix M adjuvant, and not when using alum, AddaVax or no adjuvant. With a view to creating a single-component multi-antigen vaccine, which would be more cost-effective than a multi-component vaccine, experiments were carried out to establish the virus-like particle Qβ as a platform capable of eliciting protective immunity via the display of short peptides derived from the CSP repeat region of both P. vivax and P. falciparum. For the first time, a tetramer peptide derived from the CSP repeat region of P. vivax VK210, AGDR, was shown capable of eliciting protective immunity alone. Finally, five novel linear B-cell epitopes were discovered, one from P. falciparum CSP, three from P. vivax TRAP and one from TRSP, each capable of conferring partial protection on mice. These epitopes were identified using novel screening methods, using sera from whole-protein vaccinated mice or by exploiting conservation within invasion protein sequences. Two of the protective epitopes, (NANP)6 and (ADGN long) were combined and found to enhance protective efficacy as predicted by the mathematical model. Thus this thesis lays the groundwork for the development of a single-component multi-epitope malaria vaccine with enhanced protective efficacy.

Subjects/Keywords: 616.9; Malaria; Vaccines; Immunology; Vaccine

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APA (6^th Edition):

Atcheson, E. (2017). Prospects for enhancing malaria vaccine efficacy by combining pre-erythrocytic antigens. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:6506c003-7065-4d48-b049-f5e9136443d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748790

Chicago Manual of Style (16^th Edition):

Atcheson, Erwan. “Prospects for enhancing malaria vaccine efficacy by combining pre-erythrocytic antigens.” 2017. Doctoral Dissertation, University of Oxford. Accessed January 15, 2021. http://ora.ox.ac.uk/objects/uuid:6506c003-7065-4d48-b049-f5e9136443d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748790.

MLA Handbook (7^th Edition):

Atcheson, Erwan. “Prospects for enhancing malaria vaccine efficacy by combining pre-erythrocytic antigens.” 2017. Web. 15 Jan 2021.

Vancouver:

Atcheson E. Prospects for enhancing malaria vaccine efficacy by combining pre-erythrocytic antigens. [Internet] [Doctoral dissertation]. University of Oxford; 2017. [cited 2021 Jan 15]. Available from: http://ora.ox.ac.uk/objects/uuid:6506c003-7065-4d48-b049-f5e9136443d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748790.

Council of Science Editors:

Atcheson E. Prospects for enhancing malaria vaccine efficacy by combining pre-erythrocytic antigens. [Doctoral Dissertation]. University of Oxford; 2017. Available from: http://ora.ox.ac.uk/objects/uuid:6506c003-7065-4d48-b049-f5e9136443d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748790

University of Adelaide

28. Marshall, Helen. Vaccinology: a public health revolution.

Degree: 2011, University of Adelaide

URL: http://hdl.handle.net/2440/74883

► This thesis comprises a collection of publications on new vaccines, vaccine safety and research in implementation of new vaccines into the community to inform public… (more)

▼ This thesis comprises a collection of publications on new vaccines, vaccine safety and research in implementation of new vaccines into the community to inform public health policy globally. The papers presented outline my research experience in vaccinology which has been conducted in collaboration with a number of national and international colleagues, who are included as coauthors. I have been involved in all aspects of the research including study concepts, conduct, analysis and interpretation of the results and manuscript preparation and publication. Studies in investigational vaccines outlined in Chapters 1, 2 and 4 were conducted as multicentre studies on the immunogenicity and safety of new vaccines including DTPa-HBV-Hib (diphtheria, tetanus, acellular pertussis, hepatitis B and Haemophilus influenzae type b) vaccine, DTPa-HBV-IPV (diphtheria, tetanus, acellular pertussis, hepetHis B and inactivated polio) vaccine, live intranasal attenuated influenza vaccine, Hib-MenCY (Haemophilus influenzae type b, Neisseria meningitidis serogroups C and Y) vaccine, DTPa- IPV (diphtheria, tetanus, acellular pertussis and inactivated polio) vaccine, PIV3 (parainfluenza virus type 3) vaccine and RSV-PIV3 (respiratory syncytial virus and parainfluenza type 3 virus) vaccine. Many of these vaccines are now licensed in Australia (DTPa-HBV-IPV; "Infanrix-Penta", DTPa-IPV; "InfanrixIPV", HepAB; "Twinrix") with some licensed in other countries (live attenuated influenza vaccine; "FluMist") and others soon to be licensed (Hib-MenCY) or still in clinical development (PIV3, RSV-PIV3). Licensing of vaccines has been dependent on provision of clinical data of an excellent standard, resulting from clinical studies conducted according to ICH-GCP (International Conference on Harmonisation - Good Clinical Practice) as included in this thesis. Currently, the cost of bringing a vaccine from the laboratory bench to the market is around $1 billion, with much of this cast derived from extensive clinical trial testing undertaken, often directed or influenced by regulatory authorities. Studies for neonates, young children and adolescents require specific approaches relevant to their needs. Important areas such as recruitment to studies, levels of understanding, needs of families and caregivers, and appropriate care of potentially fearful and tearful participants all need to be addressed carefully and with great skill and support. Issues of assessment of symptoms and potential adverse effects need to be approached differently to those in older independent study participants. Paediatric vaccine clinical trials can only be successfully conducted with a specialized, experienced and dedicated team of investigators with a wide range of individual skills. Each investigational participant age group requires a specific type of specialist expertise, including skills which may range from venesection of a 2 month old infant (preferably on the first attempt), to blowing bubbles to distract an anxious 4 year old being vaccinated to discussing the study… Advisors/Committee Members: School of Paediatrics and Reproductive Health (school).

Subjects/Keywords: vaccinology; public health; vaccines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marshall, H. (2011). Vaccinology: a public health revolution. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/74883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marshall, Helen. “Vaccinology: a public health revolution.” 2011. Thesis, University of Adelaide. Accessed January 15, 2021. http://hdl.handle.net/2440/74883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marshall, Helen. “Vaccinology: a public health revolution.” 2011. Web. 15 Jan 2021.

Vancouver:

Marshall H. Vaccinology: a public health revolution. [Internet] [Thesis]. University of Adelaide; 2011. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2440/74883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marshall H. Vaccinology: a public health revolution. [Thesis]. University of Adelaide; 2011. Available from: http://hdl.handle.net/2440/74883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

29. Darton, Thomas C. Application of a challenge model to assess the protective efficacy of oral typhoid vaccines in humans.

Degree: PhD, 2014, University of Oxford

URL: https://ora.ox.ac.uk/objects/uuid:4f0dfdf5-d2b0-402d-8910-e17c72eb832c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711759

► Human infection by Salmonella Typhi has been occurring for the last 50,000 years and still accounts for ∼ 22million new cases each year worldwide. Through… (more)

▼ Human infection by Salmonella Typhi has been occurring for the last 50,000 years and still accounts for ∼ 22million new cases each year worldwide. Through faeco-oral transmission, this human-restricted infection disproportionately affects the most impoverished sections of endemic communities where adequate sanitation infrastructure and effective vaccination approaches are lacking. Development of new control measures to accurately measure the burden of disease and to prevent infection with new vaccine candidates are hindered by an incomplete understanding of host-pathogen interactions and of what constitutes a protective human response after exposure. In this thesis I describe the practical application of a recently developed human challenge model of typhoid infection in assessing new control measures, including the evaluation of the oral single-dose vaccine candidate, M01ZH09. In performing a large, double-blind, placebo-controlled study, I was able to measure the direct protective efficacy (PE) of vaccination with either M01ZH09 or 3-dose Ty21a by performing human challenge with 104CFU Salmonella Typhi, Quailes strain, 28-days later. Using clinical and microbiological definitions to confirm typhoid diagnosis during a 14-day period after ingestion, I found insignificant levels of protection afforded by a single dose of M01ZH09 (12.9%), and a low PE after Ty21a vaccination (35%), demonstrating the stringency of the model and the endpoints used. Many additional insights into pathogen dynamics and host responses were found highlighting several important characteristics of oral vaccination. M01ZH09 was highly immunogenic, and both active vaccines significantly reduced bacterial burden (bacteraemia and stool shedding) while having no effect on symptomatic severity of infection in those diagnosed. M01ZH09 receipt resulted in a significantly longer incubation period, suggesting underlying protective responses were being generated. Further findings included the first objective demonstration of primary bacteraemia occurring after typhoid exposure, and frequent asymptomatic infection or stool shedding in those exposed but remaining well. Overall, these data also demonstrated significant protective effects against challenge by anti-Vi antibody status and age at baseline. Taking these factors into account, M01ZH09 and Ty21a vaccination did convey an overall protective advantage against developing typhoid infection, each reducing the risk of diagnosis by ~two-fold during the challenge period.

Subjects/Keywords: 616.9; Vaccines; Human challenge studies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Darton, T. C. (2014). Application of a challenge model to assess the protective efficacy of oral typhoid vaccines in humans. (Doctoral Dissertation). University of Oxford. Retrieved from https://ora.ox.ac.uk/objects/uuid:4f0dfdf5-d2b0-402d-8910-e17c72eb832c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711759

Chicago Manual of Style (16^th Edition):

Darton, Thomas C. “Application of a challenge model to assess the protective efficacy of oral typhoid vaccines in humans.” 2014. Doctoral Dissertation, University of Oxford. Accessed January 15, 2021. https://ora.ox.ac.uk/objects/uuid:4f0dfdf5-d2b0-402d-8910-e17c72eb832c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711759.

MLA Handbook (7^th Edition):

Darton, Thomas C. “Application of a challenge model to assess the protective efficacy of oral typhoid vaccines in humans.” 2014. Web. 15 Jan 2021.

Vancouver:

Darton TC. Application of a challenge model to assess the protective efficacy of oral typhoid vaccines in humans. [Internet] [Doctoral dissertation]. University of Oxford; 2014. [cited 2021 Jan 15]. Available from: https://ora.ox.ac.uk/objects/uuid:4f0dfdf5-d2b0-402d-8910-e17c72eb832c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711759.

Council of Science Editors:

Darton TC. Application of a challenge model to assess the protective efficacy of oral typhoid vaccines in humans. [Doctoral Dissertation]. University of Oxford; 2014. Available from: https://ora.ox.ac.uk/objects/uuid:4f0dfdf5-d2b0-402d-8910-e17c72eb832c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711759

30. Seddigh-Tonekaboni, Siamak. Hepatitis B virus 'S' gene variants : identification, expression and characterisation.

Degree: PhD, 1999, Imperial College London

URL: http://hdl.handle.net/10044/1/8612

Subjects/Keywords: 610; Vaccines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Seddigh-Tonekaboni, S. (1999). Hepatitis B virus 'S' gene variants : identification, expression and characterisation. (Doctoral Dissertation). Imperial College London. Retrieved from http://hdl.handle.net/10044/1/8612

Chicago Manual of Style (16^th Edition):

Seddigh-Tonekaboni, Siamak. “Hepatitis B virus 'S' gene variants : identification, expression and characterisation.” 1999. Doctoral Dissertation, Imperial College London. Accessed January 15, 2021. http://hdl.handle.net/10044/1/8612.

MLA Handbook (7^th Edition):

Seddigh-Tonekaboni, Siamak. “Hepatitis B virus 'S' gene variants : identification, expression and characterisation.” 1999. Web. 15 Jan 2021.

Vancouver:

Seddigh-Tonekaboni S. Hepatitis B virus 'S' gene variants : identification, expression and characterisation. [Internet] [Doctoral dissertation]. Imperial College London; 1999. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10044/1/8612.

Council of Science Editors:

Seddigh-Tonekaboni S. Hepatitis B virus 'S' gene variants : identification, expression and characterisation. [Doctoral Dissertation]. Imperial College London; 1999. Available from: http://hdl.handle.net/10044/1/8612

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Open Access Theses and Dissertations