subject:(Uterine leiomyoma)

Boston University

1. Koomson, Jacqueline Nyarkoa. The role of estrogen receptors alpha and beta in the development of uterine leiomyomas.

Degree: MS, Medical Sciences, 2017, Boston University

URL: http://hdl.handle.net/2144/23835

► Uterine leiomyomas are benign tumors within the uterus, where patients present with symptoms such as abnormal bleeding, urinary retention, and pelvic pressure. The exact etiology… (more)

▼ Uterine leiomyomas are benign tumors within the uterus, where patients present with symptoms such as abnormal bleeding, urinary retention, and pelvic pressure. The exact etiology of uterine leiomyomas is unknown, but numerous theories have been proposed, indicating a multifactorial mechanism, including lifestyle and steroid hormones. Uterine leiomyomas have become a public health concern due to the high cost of treatment as well as the high prevalence within African American communities. Currently, many treatment options exist, ranging from conservative treatments that address symptoms, to surgical intervention to remove the uterus. Research efforts thus far have determined the relationship between the role of estrogen in the growth of uterine leiomyomas (which has led to development of medications that target different approaches to estrogen synthesis) and its effects in the pathogenesis. Studies have shown that estrogen acts on estrogen receptor subtypes, ER and ER. This study examines the role of these two receptors in estrogenic effects, and how these effects relate to the development of uterine leiomyomas. Available research has shown that each receptor has its unique functions and impacts the growth of tumors differently. There is conflicting evidence in how the number of receptors and surrounding environment modulate leiomyomas, with some studies reporting that it is the corepressors and/or coactivators that ultimately determine the influence of estrogenic effects. However, the general consensus of such studies suggests that estrogen receptor-specific therapeutic intervention is a novel area with great potential. The primary benefit of estrogen receptor-specific treatment, such as selective estrogen receptor modulators, is the ability to regulate physiological processes that contribute to the growth of uterine leiomyomas. Future directions of research include confirming the exact roles of ER and ER and harnessing the effects of their differing functions to manage uterine leiomyomas.

Subjects/Keywords: Medicine; Estrogen; Estrogen receptor alpha; Estrogen receptor beta; Receptor-mediated therapies; Uterine fibroids; Uterine leiomyoma

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APA (6^th Edition):

Koomson, J. N. (2017). The role of estrogen receptors alpha and beta in the development of uterine leiomyomas. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/23835

Chicago Manual of Style (16^th Edition):

Koomson, Jacqueline Nyarkoa. “The role of estrogen receptors alpha and beta in the development of uterine leiomyomas.” 2017. Masters Thesis, Boston University. Accessed January 19, 2021. http://hdl.handle.net/2144/23835.

MLA Handbook (7^th Edition):

Koomson, Jacqueline Nyarkoa. “The role of estrogen receptors alpha and beta in the development of uterine leiomyomas.” 2017. Web. 19 Jan 2021.

Vancouver:

Koomson JN. The role of estrogen receptors alpha and beta in the development of uterine leiomyomas. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2144/23835.

Council of Science Editors:

Koomson JN. The role of estrogen receptors alpha and beta in the development of uterine leiomyomas. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/23835

Linnaeus University

2. Arponen, Felicia. Mifepristonbehandling vid myom : Effekt- och säkerhetsaspekter.

Degree: Chemistry and Biomedical Sciences, 2020, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-94171

► Bakgrund: Myom är den vanligaste gynekologiska benigna tumören hos kvinnor i fertil ålder. Det finns idag läkemedelsbehandlingar, invasiva ingrepp och icke-invasiva ingrepp vid behandling… (more)

▼ Bakgrund: Myom är den vanligaste gynekologiska benigna tumören hos kvinnor i fertil ålder. Det finns idag läkemedelsbehandlingar, invasiva ingrepp och icke-invasiva ingrepp vid behandling av myom. Utvecklingen av läkemedel mot myom är lågprioriterat, eftersom de främst är benigna och snarare leder till sjuklighet än dödlighet. De läkemedel som idag används vid behandling av myom är ulipristal, GnRH-agonister, NSAID, tranexamsyra, p-piller eller hormonspiral. Ulipristal och GnRH-agonister har utöver förbättring av symtom som alla de senast nämnda, en effekt på reducering av myomstorlek. Icke-invasiva ingrepp innefattar idag myolys, embolisering av arteria uterina och fokuserad ultraljudskirurgi under MRI-vägledning, framtagna för att slippa operativa ingrepp. Myomektomi och hysterektomi är två operativa ingrepp som genomförs om inga andra behandlingar fungerar, eftersom de medför en längre återhämtningstid och en större risk för komplikationer. Mifepriston är en antiprogesteron, vilket innebär att den hämmar progesterons effekt. Progesteron i sin tur spelar en stor roll i utvecklingen av ett myom. Behandling med läkemedlet har i många olika studier visat goda resultat både i avseende på myomstorlek, symtom, livskvalité och biverkningar. Syfte: Syftet med examensarbetet var att undersöka om mifepriston är ett säkert och effektivt läkemedel vid behandling av myom hos kvinnor. Metod: Examensarbetet är en litteraturstudie och baseras på 6 olika randomiserade kontrollerade vetenskapliga studier som undersökte mifepristons effekt och säkerhet vid behandling av myom. Studierna hämtades från PubMed. Resultat: Samtliga studier visade en reducering i myomvolym, en förbättring av symtom och milda biverkningar med olika doseringar av mifepriston vid behandling av myom. I 2 av studierna undersöktes livskvalitén vilket ökade hos de personer som behandlades med mifepriston. Slutsats: Det är svårt att dra generella slutsatser vilken dos och behandlingstid som är optimala på grund av de olika behandlingstiderna, doseringarna och studieuppläggen som användes i samtliga studier. Dock har mifepriston en god effekt avseende på reducering i myomstorlek, symtom, biverkningar och livskvalité. Det krävs dock fler studier för att säkerställa dosering och behandlingstid samt fler jämförelser med andra behandlingsalternativ som idag finns för behandling av myom.

Subjects/Keywords: Mifepristone; myoma; leiomyoma; uterine fibroids; Pharmacology and Toxicology; Farmakologi och toxikologi

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arponen, F. (2020). Mifepristonbehandling vid myom : Effekt- och säkerhetsaspekter. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-94171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arponen, Felicia. “Mifepristonbehandling vid myom : Effekt- och säkerhetsaspekter.” 2020. Thesis, Linnaeus University. Accessed January 19, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-94171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arponen, Felicia. “Mifepristonbehandling vid myom : Effekt- och säkerhetsaspekter.” 2020. Web. 19 Jan 2021.

Vancouver:

Arponen F. Mifepristonbehandling vid myom : Effekt- och säkerhetsaspekter. [Internet] [Thesis]. Linnaeus University; 2020. [cited 2021 Jan 19]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-94171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arponen F. Mifepristonbehandling vid myom : Effekt- och säkerhetsaspekter. [Thesis]. Linnaeus University; 2020. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-94171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kansas

3. Farahbakhsh, Mina. Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids.

Degree: PhD, Molecular & Integrative Physiology, 2017, University of Kansas

URL: http://hdl.handle.net/1808/26945

► Uterine fibroids, also known as leiomyomas, are benign smooth muscle cell (SMC) tumors of the myometrium and are the most frequent reason for a hysterectomy.… (more)

▼ Uterine fibroids, also known as leiomyomas, are benign smooth muscle cell (SMC) tumors of the myometrium and are the most frequent reason for a hysterectomy. Although benign, these tumors pose a significant burden on patients with symptoms of abdominal pain, pressure, uterine bleeding, and infertility; creating a great liability for the US economy with an annual estimated cost of up to $34 billion. Currently there are no long-term treatments for fibroids that will leave fertility intact, mainly because the mechanism of pathogenesis of these tumors is largely unknown. One of the key characteristics of uterine fibroids is the excessive deposition and reorganization of extracellular matrix (ECM). Altered ECM, which amplifies growth factor signaling and disrupts mechanosensing, has been proposed to promote fibroid tumor growth. Analysis of available gene expression datasets from GEO database indicates that ADAM12 expression is dramatically upregulated in fibroids. As a member of the A-Disintegrin And Metalloprotease family of matrix modifying enzymes, ADAM12 is known to cleave ECM proteins, activate epidermal growth factor (EGF) and Insulin-like growth factor (IGF) signaling and promote tumorigenesis. Our lab has recently shown the expression of RE1 suppressing transcription factor /neuron-restrictive silencing factor (REST/NRSF), a known tumor suppressor, to be lost in fibroids. Upon further analysis, we found silencing REST in primary myometrial SMCs led to an increase in a number of downstream target genes, a profile similar to what is seen in fibroid tumor samples. Furthermore, Ingenuity® pathway analyses of gene expression datasets for fibroids indicate that the loss of REST and the increase in ADAM12 expression in leiomyomas could be linked through microRNA-29 (miR-29). In addition, in cultured mammary tumor cell lines, miR-29 is known to directly regulate ADAM12 expression. Compared to normal myometrium, uterine fibroids express significantly lower levels of miR-29. In its promoter, miR-29 contains an RE1 element, a putative binding site for REST. In order to see how the loss of REST in fibroids could affect miR-29, we silenced REST in primary myometrial SMCs and saw a significant decrease in miR-29 expression. In addition, Western blot analysis showed an increase in ADAM12 expression and EGF receptor (EGFR) phosphorylation when REST was knocked-down in primary myometrial cells. We further investigated the link between miR-29 and ADAM12 expression by treating primary myometrial and leiomyoma cells with miR-29 inhibitors and mimics, respectively. We found that inhibiting miR-29 in myometrial cells results in an increase in the expression of ADAM12. Conversely, the opposite effects were seen when fibroid cells were treated with miR-29 mimics. Furthermore, overexpression of ADAM12 in primary myometrial SMCs was found to induce activation of multiple tumorigenic signaling pathways including EGFR, Mitogen-activated protein kinase (MAPK), the phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/Akt), and… Advisors/Committee Members: Chennathukuzhi, Vargheese M (advisor), Blanco, Gustavo (cmtemember), Rongish, Brenda J (cmtemember), Nothnick, Warren B (cmtemember), Jensen, Roy A (cmtemember).

Subjects/Keywords: Physiology; ADAM12; Leiomyoma; MicroRNA-29; Notch; REST; Uterine Fibroids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farahbakhsh, M. (2017). Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids. (Doctoral Dissertation). University of Kansas. Retrieved from http://hdl.handle.net/1808/26945

Chicago Manual of Style (16^th Edition):

Farahbakhsh, Mina. “Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids.” 2017. Doctoral Dissertation, University of Kansas. Accessed January 19, 2021. http://hdl.handle.net/1808/26945.

MLA Handbook (7^th Edition):

Farahbakhsh, Mina. “Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids.” 2017. Web. 19 Jan 2021.

Vancouver:

Farahbakhsh M. Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids. [Internet] [Doctoral dissertation]. University of Kansas; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1808/26945.

Council of Science Editors:

Farahbakhsh M. Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids. [Doctoral Dissertation]. University of Kansas; 2017. Available from: http://hdl.handle.net/1808/26945

University of Kansas

4. McWilliams, Michelle Marie. A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma.

Degree: PhD, Molecular & Integrative Physiology, 2017, University of Kansas

URL: http://hdl.handle.net/1808/26943

► Uterine Leiomyoma (UL), also known as Uterine Fibroids, are benign, hormone-sensitive tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL… (more)

▼ Uterine Leiomyoma (UL), also known as Uterine Fibroids, are benign, hormone-sensitive tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, with lifetime occurrence in up to 77% of all women. A third of women with UL require treatment for clinically significant symptoms of menorrhagia, severe pain, anemia and fertility complications, resulting in over 200,000 hysterectomies and up to $34.4 billion in medical costs in the United States each year. Despite the prevalence of UL, currently no treatment for UL is long-term, cost effective and leaves fertility intact. There is a pressing need to develop better pharmacotherapies for the treatment of UL. Remarkably, very little is known about the molecular pathogenesis of UL. Environmental estrogen exposure is one of the most recognized risk factors associated with the development of UL tumors. At the cellular level, extensive evidence has linked the cell proliferation, survival and growth of UL tumors to the over-activation of the PI3K/AKT-mTOR pathway. This work establishes, for the first time, a comprehensive molecular pathway starting from known environmental estrogen risk factors leading to activation of the most crucial cell proliferation pathway in UL. We identified the most overexpressed G-protein coupled receptor in UL as the neuronspecific GPR10 (PRLHR), which activates the PI3K/AKT-mTOR pathway in UL cells upon stimulation by its ligand, PrRP (Prolactin-Releasing Peptide). Epigenetic silencing of GPR10 in non-neuronal cells is accomplished by the tumor-suppressor REST (Repressor Element Silencing Transcription factor), which we found to be drastically down-regulated at the protein level in UL tissue. In addition to GPR10, many of the most dysregulated genes in UL tissue are direct targets iv of REST, implicating the central role of the loss of REST in the pathogenesis of UL. In our investigations on the degradation of REST in UL, we found significant under-expression of PRICKLE1, the protein required for REST localization to the nucleus. We have found that PRICKLE1 expression in the uterine myometrium is regulated by estrogen through Estrogen Receptor-α and that the loss of PRICKLE1 leads to the destabilization and degradation of REST protein in UL. We found overexpression of the polycomb repressor complex protein EZH2 (Enhancer of Zeste Homolog 2) participates in repression of PRICKLE1 in UL. Furthermore, we provide two important preclinical mouse models, which are among the first in the UL field that recapitulate genes dysregulated in human UL. We show that mice expressing hGPR10 in the uterus, and a conditional knockout of REST in the reproductive tract, show UL phenotype. This work establishes a novel molecular pathway in UL pathogenesis linking upstream estrogen signaling to downstream PI3K/AKT-mTOR pathway activation and provides potential drug targets and preclinical mouse models for improved treatment of UL. Advisors/Committee Members: Chennathukuzhi, Vargheese M (advisor), Nothnick, Warren B (cmtemember), Kumar, T. Rajendra (cmtemember), Blanco, Gustavo (cmtemember), Durham, Dianne (cmtemember).

Subjects/Keywords: Molecular biology; Physiology; Endocrinology; animal models; developmental reprogramming; environmental estrogens; uterine fibroids; uterine leiomyoma; uterine pathophysiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McWilliams, M. M. (2017). A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma. (Doctoral Dissertation). University of Kansas. Retrieved from http://hdl.handle.net/1808/26943

Chicago Manual of Style (16^th Edition):

McWilliams, Michelle Marie. “A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma.” 2017. Doctoral Dissertation, University of Kansas. Accessed January 19, 2021. http://hdl.handle.net/1808/26943.

MLA Handbook (7^th Edition):

McWilliams, Michelle Marie. “A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma.” 2017. Web. 19 Jan 2021.

Vancouver:

McWilliams MM. A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma. [Internet] [Doctoral dissertation]. University of Kansas; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1808/26943.

Council of Science Editors:

McWilliams MM. A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma. [Doctoral Dissertation]. University of Kansas; 2017. Available from: http://hdl.handle.net/1808/26943

Universidade do Rio Grande do Sul

5. Sant'Anna, Gabriela dos Santos. Mecanismos epigenéticos em leiomiomas uterinos e o efeito da mifepristona (RU 486) na expressão gênica dos receptores de progesterona total e B.

Degree: 2017, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/169713

► Introdução: Leiomiomas uterinos ou miomas são tumores benignos que se desenvolvem no miométrio e acometem cerca de 50% da população feminina. Têm como principais sintomas,… (more)

▼ Introdução: Leiomiomas uterinos ou miomas são tumores benignos que se desenvolvem no miométrio e acometem cerca de 50% da população feminina. Têm como principais sintomas, sangramento excessivo e dor pélvica inespecífica. Convencionalmente o estrogênio é considerado o responsável pelo início da proliferação tumoral, mas recentes evidências clínicas e bioquímicas sugerem que a progesterona apresenta um papel importante no desenvolvimento desses tumores. Além disso, mecanismos epigenéticos parecem estar envolvidos na etiologia dos leiomiomas uterinos, como a metilação de DNA e acetilação de histonas. Somente nos EUA são realizadas 240 mil histerectomias/ano para tratar essa doença sendo considerado um problema de saúde pública. Frente a esses dados é imprescindível o entendimento dos mecanismos moleculares envolvidos no desenvolvimento desses tumores e a busca de tratamentos menos invasivos. A mifepristona (RU 486), um modulador seletivo dos receptores de progesterona e glicocorticoides, é capaz de diminuir o tamanho dos tumores e amenizar os sintomas associados. Objetivos: verificar se (1) nos tecidos de leiomiomas uterinos e miométrio, os mecanismos epigenéticos como a metilação global do DNA e a acetilação de histonas estão alterados (2) se em cultura primária de leiomioma uterino e miométrio o tratamento com estradiol e progesterona é capaz de modular a expressão gênica dos receptores de progesterona total e B, assim como a atividade das enzimas histona acetiltransferase e desacetilase, e (3) se a mifepristona (RU 486) é capaz de modular diretamente a expressão gênica dos receptores de progesterona total e B após tratamento com os hormônios estradiol e progesterona. Métodos: para análise de metilação global do DNA e acetilação de histonas foram utilizadas 25 amostras teciduais para cada grupo de leiomioma uterino e miométrio oriundos de pacientes submetidas à histerectomia no Hospital de Clínicas de Porto Alegre. A metilação global do DNA e a atividade da enzima histona acetiltransferase foram dosadas pelo método de ELISA e a enzima histona desacetilase por detecção fluorimétrica. Para verificar o efeito dos hormônios sexuais ovarianos e o efeito da mifepristona (RU 486) sobre a expressão gênica dos receptores de progesterona total e B foram realizadas 7 culturas primárias de leiomiomas uterinos e miométrio. Resultados: (1) Foram observadas hipermetilação (P = 0,022) e hipoacetilação (P = 0,04) em leiomiomas uterinos quando comparado ao miométrio. Não houve diferença estatística entre estes tecidos em relação à atividade da histona acetiltransferase. (2) Houve aumento da expressão gênica do receptor de progesterona total em cultura primária de leiomioma uterino quando tratado com estradiol (P = 0,028) e o receptor de progesterona B teve sua expressão aumentada quando tratado com estradiol, progesterona e estradiol + progesterona (P = 0,001). (3) O tratamento com mifepristona (RU 486) na dose de 10-6M não foi capaz de diminuir a expressão gênica dos receptores de progesterona total e B em células de leiomiomas… Advisors/Committee Members: Corleta, Helena von Eye.

Subjects/Keywords: Leiomioma; Uterine leiomyoma; Epigênese genética; Progesterone; Metilação de DNA; Estradiol; Mifepristone; Mifepristona; Estradiol; Epigenetic; Progesterona

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sant'Anna, G. d. S. (2017). Mecanismos epigenéticos em leiomiomas uterinos e o efeito da mifepristona (RU 486) na expressão gênica dos receptores de progesterona total e B. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/169713

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sant'Anna, Gabriela dos Santos. “Mecanismos epigenéticos em leiomiomas uterinos e o efeito da mifepristona (RU 486) na expressão gênica dos receptores de progesterona total e B.” 2017. Thesis, Universidade do Rio Grande do Sul. Accessed January 19, 2021. http://hdl.handle.net/10183/169713.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sant'Anna, Gabriela dos Santos. “Mecanismos epigenéticos em leiomiomas uterinos e o efeito da mifepristona (RU 486) na expressão gênica dos receptores de progesterona total e B.” 2017. Web. 19 Jan 2021.

Vancouver:

Sant'Anna GdS. Mecanismos epigenéticos em leiomiomas uterinos e o efeito da mifepristona (RU 486) na expressão gênica dos receptores de progesterona total e B. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10183/169713.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sant'Anna GdS. Mecanismos epigenéticos em leiomiomas uterinos e o efeito da mifepristona (RU 486) na expressão gênica dos receptores de progesterona total e B. [Thesis]. Universidade do Rio Grande do Sul; 2017. Available from: http://hdl.handle.net/10183/169713

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Zlotnik, Eduardo. Parâmetros de ressonância magnética da pelve como fatores preditivos de resposta de leiomioma uterino à embolização arterial.

Degree: PhD, Obstetrícia e Ginecologia, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-11092012-095441/ ;

►

Os métodos minimamente invasivos têm sido cada vez mais utilizados para o tratamento do leiomioma e, a embolização da artéria uterina, tem se destacado como… (more)

▼

Os métodos minimamente invasivos têm sido cada vez mais utilizados para o tratamento do leiomioma e, a embolização da artéria uterina, tem se destacado como método seguro e efetivo. O objetivo deste estudo foi avaliar, pela ressonância magnética da pelve, os fatores preditores da diminuição dos leiomiomas de pacientes submetidos a embolização da artéria uterina. Métodos: Estudaram-se 50 mulheres sintomáticas com leiomioma uterino, na menacme, que foram submetidas a embolização da artéria uterina. Acompanhou-se, por meio da ressonância magnética o volume do útero e dos leiomiomas. Foram examinados 179 leiomiomas nestas pacientes, um mês antes e seis meses depois do procedimento. Resultados: Seis meses após o tratamento, a redução média do volume uterino foi de 38,91%, enquanto os leiomiomas tiveram redução de 55,23%. Nos leiomiomas submucosos e/ou com a relação nódulo/músculo em T2 mais elevada, a redução do volume foi ainda maior (maior que 50,00%). Conclusões: As pacientes portadoras de leiomiomas e submetidas à embolização da artéria uterina apresentaram redução de volume dos nódulos superior a 50,00%, à ressonância magnética, quando eram submucosos e/ou tinham uma relação nódulo/músculo em T2 mais elevada

Objective : Minimally invasive methods are being an alternative to treat leiomyomas, including the uterine artery embolization that has emerged as a safe and effective method. The aim of this study was to evaluate the magnetic resonance imaging predictors of decrease in leiomyomas of patients who underwent uterine artery embolization. Methods: This study followed 50 symptomatic premenopausal women with uterine leiomyoma who underwent uterine artery embolization. Treatment was accompanied by magnetic resonance imaging of both the volume of the uterus and the leiomyomas. We examined 179 leiomyomas in that 50 patients, one month before and six months after of the procedure. Results: Six months after treatment, the mean reduction in uterine was 38.91%, while leiomyomas decreased by 55.23%. In submucosal leiomyomas and/or with a higher node/muscle ratio in T2, the volume reduction was even higher (greater than 50.00%). Conclusions: The patients with leiomyomas and underwent uterine artery embolization, showed reductions in the volume of nodes greater than 50,00%, on the magnetic resonance imaging, when they were submucosal and / or had a higher node-to-muscle ratio in T2

Advisors/Committee Members: Messina, Marcos de Lorenzo.

Subjects/Keywords: Embolização da artéria uterina; Imagem por ressonância magnética; Leiomyoma; Magnetic resonance imaging; Mioma; Uterine artery embolization

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zlotnik, E. (2012). Parâmetros de ressonância magnética da pelve como fatores preditivos de resposta de leiomioma uterino à embolização arterial. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-11092012-095441/ ;

Chicago Manual of Style (16^th Edition):

Zlotnik, Eduardo. “Parâmetros de ressonância magnética da pelve como fatores preditivos de resposta de leiomioma uterino à embolização arterial.” 2012. Doctoral Dissertation, University of São Paulo. Accessed January 19, 2021. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-11092012-095441/ ;.

MLA Handbook (7^th Edition):

Zlotnik, Eduardo. “Parâmetros de ressonância magnética da pelve como fatores preditivos de resposta de leiomioma uterino à embolização arterial.” 2012. Web. 19 Jan 2021.

Vancouver:

Zlotnik E. Parâmetros de ressonância magnética da pelve como fatores preditivos de resposta de leiomioma uterino à embolização arterial. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Jan 19]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-11092012-095441/ ;.

Council of Science Editors:

Zlotnik E. Parâmetros de ressonância magnética da pelve como fatores preditivos de resposta de leiomioma uterino à embolização arterial. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-11092012-095441/ ;

Freie Universität Berlin

7. Kösters, Clemens. Long-term outcome after uterine artery embolization in patients with symptomatic leiomyoma.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9262

► Purpose: Uterine artery embolisation (UAE) is a therapeutic option for patients with symptomatic leiomyomata fibroids of the uterus. The study presented here, evaluates the clinical… (more)

▼ Purpose: Uterine artery embolisation (UAE) is a therapeutic option for patients with symptomatic leiomyomata fibroids of the uterus. The study presented here, evaluates the clinical long-term results of this procedure with regard to symptom control and quality-of-life of as well as factors that may influence therapeutic success or failure. Material and Methods: Between 10/2000 and 10/2007 380 patients were treated and included in this analysis. Using an standardized questionnaire data on re-interventions, fibroid-related symptoms (bleeding and pressure symptoms) and quality-of-life were collected. Re-interventions, worsening of fibroid-related symptoms or quality-of-life were defined as a failure of therapy. Using a Kaplan-Meier-Analysis the event- free survival (endpoint: therapy failure) was calculated. A cox regression analysis was carried out to determine if clinical or anatomical factors influence clinical outcome. A subgroup of patients (n=115) underwent contrast- enhanced MRI to investigate the relationship between infarction of fibroids and clinical outcome. Another subgroup of patients (n=91) with single fibroids were analyzed to determine if anatomical factors relate to the type of symptoms. Results: 304 of 380 patients (80 %) returned information that could be analyzed. Median follow-up was 5,7 years (range: 3,1 – 10,1 years). Kaplan- Meier-Analysis showed that ten years after UAE up to 23,3 % of women reported failure of therapy. Cox-regression analysis demonstrated that patients under the age of forty have a significant higher risk of clinical failure (Hazard Ratio: 2,28, p=0,049). Patients with a positive long-term result after UAE reported similiar Quality-of-life compared to a a group of patients without fibroids (p<0,001). Patients with an infarction rate of leiomyoma below 89 % had a 22,2-fold higher risk for therapy failure than women with a 90-99 % or 100 % infarction rate (p<0,001). The combination bleeding symptoms and an infarction rate of less than 89% was associated with a 40,5-fold increased risk for therapy failure as compared to a group of women with pressure and bleeding symptoms or an infarction rate >90%. No correlation between anatomical variables and fibroid-related symptoms could be found. Conclusion: UAE for symptomatic fibroids leads to long-term symptom control in 75 % of women and is associated with an improvement in quality-of-life comparable to women without disease. No correlation between anatomical factors and clinical symptoms was found. Women under age of 40 and bleeding symptoms are a higher risk for clinical failure after UAE. An infarction rate of > 90% of leiomyoma tissue after UAE is a strong positive predictor for clinical success. Advisors/Committee Members: m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: uterine artery embolization; magnetic resonance imaging; leiomyoma; women’s health; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kösters, C. (2015). Long-term outcome after uterine artery embolization in patients with symptomatic leiomyoma. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9262

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kösters, Clemens. “Long-term outcome after uterine artery embolization in patients with symptomatic leiomyoma.” 2015. Thesis, Freie Universität Berlin. Accessed January 19, 2021. http://dx.doi.org/10.17169/refubium-9262.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kösters, Clemens. “Long-term outcome after uterine artery embolization in patients with symptomatic leiomyoma.” 2015. Web. 19 Jan 2021.

Vancouver:

Kösters C. Long-term outcome after uterine artery embolization in patients with symptomatic leiomyoma. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Jan 19]. Available from: http://dx.doi.org/10.17169/refubium-9262.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kösters C. Long-term outcome after uterine artery embolization in patients with symptomatic leiomyoma. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-9262

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Medical Branch – Galveston

8. [No author]. Novel Effects of Simvastatin on Uterine Fibroids .

Degree: University of Texas Medical Branch – Galveston

URL: http://hdl.handle.net/2152.3/729

► Uterine fibroids (also known as leiomyomas) represent a common gynecologic problem with a significant medical and economic burden. Unfortunately, no satisfactory long-term medical treatment is… (more)

▼ Uterine fibroids (also known as leiomyomas) represent a common gynecologic problem with a significant medical and economic burden. Unfortunately, no satisfactory long-term medical treatment is currently available. Statins are drugs commonly used for the treatment of high plasma cholesterol levels. Beyond these well-known lipid-lowering properties, they possess broad reaching effects in vivo which include anti-tumor effects. Statins inhibit the growth of multiple tumors; however the mechanisms remain incompletely understood. The purpose of this study was to examine the effects of simvastatin on uterine fibroid, both in vitro and using an animal model. For the in vitro studies, we used primary and immortalized human fibroid cells. For the in vivo studies, we used immunodeficient mice supplemented with estrogen/progesterone pellets xenografted with human fibroid tissue explant. We found that simvastatin inhibits the proliferation of human fibroid cells. This was associated with decreased mitogen-activated protein kinase signaling and multiple changes in cell cycle progression. Simvastatin potently induced fibroid cell apoptosis in a manner mechanistically dependent upon apoptotic calcium release from L-type voltage-gated calcium channels. Thus, simvastatin possesses anti-tumor effects which are dependent upon the apoptotic calcium release machinery. For the in vivo studies, animals were treated with simvastatin vs vehicle control. The treatment inhibited tumor growth as measured weekly using calipers and/ or ultrasound. Finally, simvastatin decreased the expression of the proliferation marker Ki67 in xenograft tumor tissue as examined by immunohistochemistry. In conclusion, simvastatin can be a promising treatment for uterine fibroid. Further studies, including pharmacokinetic and drug delivery studies, are required. Advisors/Committee Members: Barral, Jose (advisor), Boehning, Darren (committeeMember), Elferink, Lisa (committeeMember), Cheng, Xiaodong (committeeMember), Ozpolat, Bulent (committeeMember).

Subjects/Keywords: Uterine fibroids; leiomyoma; simvastatin; statins; calcium; apoptosis; mouse model

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

author], [. (n.d.). Novel Effects of Simvastatin on Uterine Fibroids . (Thesis). University of Texas Medical Branch – Galveston. Retrieved from http://hdl.handle.net/2152.3/729

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Novel Effects of Simvastatin on Uterine Fibroids .” Thesis, University of Texas Medical Branch – Galveston. Accessed January 19, 2021. http://hdl.handle.net/2152.3/729.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Novel Effects of Simvastatin on Uterine Fibroids .” Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

author] [. Novel Effects of Simvastatin on Uterine Fibroids . [Internet] [Thesis]. University of Texas Medical Branch – Galveston; [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152.3/729.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

author] [. Novel Effects of Simvastatin on Uterine Fibroids . [Thesis]. University of Texas Medical Branch – Galveston; Available from: http://hdl.handle.net/2152.3/729

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Texas Medical Branch – Galveston

9. [No author]. Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology .

Degree: University of Texas Medical Branch – Galveston

URL: http://hdl.handle.net/2152.3/10721

► Endometrial adenocarcinoma and leiomyomas are prevalent disorders of the same organ. Endometrial cancer, the most prevalently diagnosed gynecological cancer, is associated with mutated PTEN tumor… (more)

Subjects/Keywords: uterine; endometrial cancer; leiomyoma; fibroid; ACTBL2; epigenetic; mutation; menstruation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

author], [. (n.d.). Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology . (Thesis). University of Texas Medical Branch – Galveston. Retrieved from http://hdl.handle.net/2152.3/10721

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology .” Thesis, University of Texas Medical Branch – Galveston. Accessed January 19, 2021. http://hdl.handle.net/2152.3/10721.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology .” Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

author] [. Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology . [Internet] [Thesis]. University of Texas Medical Branch – Galveston; [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152.3/10721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

author] [. Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology . [Thesis]. University of Texas Medical Branch – Galveston; Available from: http://hdl.handle.net/2152.3/10721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Freie Universität Berlin

10. Scheurig-Münkler, Christian. clinical long-term efficacy and factors influencing the outcome.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9585

► Publication 1 presents a prospective study of 15 women examined with contrast- enhanced magnetic resonance imaging (MRI). The study shows that bilateral uterine artery embolization… (more)

▼ Publication 1 presents a prospective study of 15 women examined with contrast- enhanced magnetic resonance imaging (MRI). The study shows that bilateral uterine artery embolization (UAE) consistently causes ischemia of both fibroids embedded within the uterine wall and of the myometrium itself. However, while reduced blood flow to the muscle layer of the uterus is temporary and usually returns to near-normal within 72 hours, ischemic fibroid tissue remains nonviable and does not recover, which is crucial for the long- term success of UAE treatment. Long-term outcome of UAE was investigated in two prospective cohort studies (publications 2 and 3) including 380 and 82 patients. Approx. three quarters of the women treated benefited permanently from UAE and reported satisfactory improvement or resolution of bleeding problems and bulk-related symptoms. Mean survival without reintervention was 8.5 years, meaning that the majority of women experience relief of fibroid- related symptoms that is maintained to the time of natural menopause. Thus, women aged <40 years at the time of UAE had a slightly over two times higher risk of treatment failure than women aged >45 years (P = 0.049). Premature menopause was not observed. Disease-specific quality of life of successfully treated women already returned to normal during short-term follow-up (P < 0,001) and improved further at long-term follow-up (P = 0.041), suggesting that a therapeutic benefit of UAE goes beyond mere control of typical fibroid- related complaints. Nevertheless, approx. one quarter of women undergoing UAE have no long-term benefit and experience a recurrence of their symptoms. Publication 4 prospectively investigated factors potentially influencing the clinical success of UAE in 115 patients, identifying the rate of fibroid infarction as the only relevant and very reliable predictor of the response to treatment. Patients with infarction of <90 % of their fibroid load had a 22.2 times (P < 0.001) higher risk of treatment failure than women in whom complete infarction was accomplished. At long-term follow-up, this difference resulted in a cumulative reintervention rate of 43% versus 2%. The infarction rate accomplished appeared to be most relevant in women presenting with abnormal bleeding as the predominant fibroid-related complaint. In this subgroup, the risk of treatment failure was 40.5 times higher, and the reintervention rate at 4-year follow-up was 94% versus 13% (P < 0.001). In rare instances, complete infarction cannot be accomplished by UAE alone since dilated ovarian arteries may provide relevant fibroid blood supply. Publication 5 presents a retrospective analysis of 13 women, showing that supplementary OAE is technically easy to perform and effectively contributes to infarction of the fibroid bulk and elimination of clinical symptoms. Satisfactory improvement of symptoms was reported by 92% of the women with supplementary OAE. There was no risk for premature permanent amenorrhea. Publication 6, which reports a retrospective study of 40 patients,… Advisors/Committee Members: m (gender), Prof. Dr. Michael Uder (firstReferee), Prof. Dr. Thomas Helmberger (furtherReferee).

Subjects/Keywords: fibroid; leiomyoma; uterine artery; embolization; adenomyosis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Scheurig-Münkler, C. (2014). clinical long-term efficacy and factors influencing the outcome. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Scheurig-Münkler, Christian. “clinical long-term efficacy and factors influencing the outcome.” 2014. Thesis, Freie Universität Berlin. Accessed January 19, 2021. http://dx.doi.org/10.17169/refubium-9585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Scheurig-Münkler, Christian. “clinical long-term efficacy and factors influencing the outcome.” 2014. Web. 19 Jan 2021.

Vancouver:

Scheurig-Münkler C. clinical long-term efficacy and factors influencing the outcome. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Jan 19]. Available from: http://dx.doi.org/10.17169/refubium-9585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Scheurig-Münkler C. clinical long-term efficacy and factors influencing the outcome. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-9585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

11. Koohestani, Faezeh. Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone.

Degree: PhD, 0002, 2013, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/42484

► Uterine leiomyomas are known as the most commonly occurring neoplasms in women during their reproductive years. The overall incidence of these benign tumors can be… (more)

▼ Uterine leiomyomas are known as the most commonly occurring neoplasms in women during their reproductive years. The overall incidence of these benign tumors can be as high as 70-80%, which represents a significant health problem to women. Patients suffer from abnormal uterine bleeding, pelvic pain, and reproductive dysfunctions. Available treatments for symptomatic patients are limited and this is in large part due to the fact that the mechanisms regulating the development and growth of these tumors are still not well understood. Two essential features of leiomyoma tumors, which arise from the uterine smooth muscle cells, are an increase in smooth muscle cell (SMC) proliferation and excessive, aberrant deposition of extracellular matrix (ECM) collagen. The objective of this dissertation was to first understand the mechanisms regulating the development and growth of leiomyoma tumors in the context of ECM collagen and second, to test the inhibitory effects of the anti-fibrotic drug, halofuginone (HF), on the growth of leiomyoma tumors in both in vitro and in vivo model systems. Our research in understanding the pathogenesis of leiomyomas showed that (1) monomeric and fibrillar forms of ECM collagen can differentially regulate the morphology and proliferation of leiomyoma smooth muscle cells (LSMCs); (2) physical properties of fibrillar collagen such as density and thickness can modulate the morphology and growth of LSMCs; (3) expression and localization of actin stress fibers as well as focal adhesion proteins such as vinculin and focal adhesion kinase are altered on different collagen matrices; (4) a synergistic effect between monomeric collagen and PDGF can further enhance the proliferation of LSMCs; and (5) the MAPK signaling pathway is involved in the interaction of LSMCs with collagen matrices. These findings demonstrate how the excess, aberrant deposition of ECM collagen in fibrotic uterine tissue can contribute to the the formation and growth of leiomyoma tumors through modulation of major cell signaling pathways. Our in vitro studies with the anti-fibrotic drug HF demonstrated that (1) this drug can inhibit LSMC proliferation under both basal and PDGF-stimulated conditions; (2) HF can significantly reduce transcript levels of COL11A1, COL3A1, TGFβ1, TGFβ3, DMT and LOX3 in a time-depenedent manner; (3) expression of collagen I and III proteins were reduced by HF in a time-dependent manner; (4) PDGF-stimulated activation of the MAPK and SRC signaling pathways is not significantly inhibited by HF; and (5) HF itself could also activate the MAPK and SRC signaling pathways. These findings suggest that the antifibrotic drug HF may be an effective therapeutic treatment for patients with ULs. Our compelementary in vivo studies on the effects of HF in a mouse model xenografted with human LSMCs showed that (1) treatment with HF at 0.25 mg/kg body weight/day and 0.5 mg/kg body weight/ every-other-day (EOD) were safe for host mice while 0.50 mg/kg body weight treatment on a daily basis was not well tolerated… Advisors/Committee Members: Nowak, Romana A. (advisor), Nowak, Romana A. (Committee Chair), Flaws, Jodi A. (committee member), Kim, Julie (committee member), Miller, David J. (committee member).

Subjects/Keywords: Uterine leiomyoma; Fibroids; Extracellular Matrix (ECM); Collagen; Smooth muscle cell; platelet-derived growth factor (PDGF); Halofuginone; Xenograft

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koohestani, F. (2013). Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/42484

Chicago Manual of Style (16^th Edition):

Koohestani, Faezeh. “Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone.” 2013. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 19, 2021. http://hdl.handle.net/2142/42484.

MLA Handbook (7^th Edition):

Koohestani, Faezeh. “Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone.” 2013. Web. 19 Jan 2021.

Vancouver:

Koohestani F. Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2142/42484.

Council of Science Editors:

Koohestani F. Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2013. Available from: http://hdl.handle.net/2142/42484

Freie Universität Berlin

12. Russ, Manon Aude Marie. Offen-abdominale Myomenukleation bei 631 Patientinnen – perioperativer Verlauf und postoperative Patientinnenzufriedenheit.

Degree: 2020, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-26659

► Introduction: Uterine fibroids are among the most common benign tumors in women of reproductive age. Abdominal myomectomy is an established standard procedure in fibroid treatment.… (more)

▼ Introduction: Uterine fibroids are among the most common benign tumors in women of reproductive age. Abdominal myomectomy is an established standard procedure in fibroid treatment. The subject of this study is the evaluation of the perioperative course of abdominal myomectomy as well as postoperative patient satisfaction. Methods: The data from 631 patients who underwent abdominal myomectomy from February 2002 to August 2015 at the Department of Gynecology, Charité Berlin Campus Virchow-Klinikum was evaluated. 392 patients (62.1%) were interviewed by questionnaire postoperatively. Results: Average operation time and average blood loss were 61.4 minutes and 410 ml, respectively. The intraoperative complication rate was low (3.3%) with increased intraoperative bleeding as the most common complication (2.3%). The postoperative complication rate was 17.9%. The postoperative infection rate was 4.8%. There were significantly fewer postoperative infections when perioperative antibiotic prophylaxis was administered. The size of the dominant fibroid and the total weight of the removed fibroids partially showed a significant correlation to blood loss, operation time as well as intra- and postoperative complications. The following significant predictors of intraoperative blood loss ≥ 500 ml were identified through logistic regression analysis: size of the dominant fibroid, total fibroid weight and the patient’s age. Subgroup analysis for fibroids of different sizes (< 5 cm, 5–9.99 cm, ≥ 10 cm) did not show an increase in perioperative complication or transfusion rate between the groups. Significant differences in the perioperative course existed with a prolonged operation time and a higher blood loss for patients with fibroids ≥ 10 cm. Patients with previous abdominal surgery also had no increased perioperative complication or transfusion rate. Again, only the duration of surgery and the intraoperative blood loss were significantly increased. On average, the patients were on sick leave for 32 days and felt impaired in their daily lives for 56.6 days. There was a significant negative correlation between sick leave duration and postoperative Hb value. In the postoperative survey, 86.6% of the patients said they were satisfied with their scar. 90.3% reported a postoperative symptom improvement and 82.1% would recommend the operation. The recommendation of the surgery showed a significant correlation to the length of the scar. Conclusion: Abdominal myomectomy is a safe procedure in the treatment of uterine fibroids. Overall, the perioperative complication rate is low. There is no relevant increase in perioperative morbidity, especially for patients with large fibroids. The patients are satisfied postoperatively and would recommend the surgery. A return to work is possible after almost a month. Advisors/Committee Members: female (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: myomectomy; uterine fibroid; leiomyoma; therapeutic outcome; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Russ, M. A. M. (2020). Offen-abdominale Myomenukleation bei 631 Patientinnen – perioperativer Verlauf und postoperative Patientinnenzufriedenheit. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-26659

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Russ, Manon Aude Marie. “Offen-abdominale Myomenukleation bei 631 Patientinnen – perioperativer Verlauf und postoperative Patientinnenzufriedenheit.” 2020. Thesis, Freie Universität Berlin. Accessed January 19, 2021. http://dx.doi.org/10.17169/refubium-26659.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Russ, Manon Aude Marie. “Offen-abdominale Myomenukleation bei 631 Patientinnen – perioperativer Verlauf und postoperative Patientinnenzufriedenheit.” 2020. Web. 19 Jan 2021.

Vancouver:

Russ MAM. Offen-abdominale Myomenukleation bei 631 Patientinnen – perioperativer Verlauf und postoperative Patientinnenzufriedenheit. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Jan 19]. Available from: http://dx.doi.org/10.17169/refubium-26659.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Russ MAM. Offen-abdominale Myomenukleation bei 631 Patientinnen – perioperativer Verlauf und postoperative Patientinnenzufriedenheit. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-26659

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

13. INGRAHAM, SUSAN ELIZABETH. THE BALANCED, RECIPROCAL TRANSLOCATION OF CHROMOSOMAL SUBBANDS 12q15 AND 14q24 AND ALTERED GENE EXPRESSION IN UTERINE LEIOMYOMA.

Degree: PhD, Medicine : Molecular Genetics, Biochemistry and Microbiology, 2002, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029433658

► A balanced, reciprocal translocation between chromosomes 12 and 14 is frequently observed in uterine leiomyoma (UL), a common benign smooth muscle tumor. Cytogenetic evidence suggests… (more)

▼ A balanced, reciprocal translocation between chromosomes 12 and 14 is frequently observed in uterine leiomyoma (UL), a common benign smooth muscle tumor. Cytogenetic evidence suggests that t(12;14)(q15;q24) is an early event and therefore may represent one of the important steps in UL pathogenesis. The breakpoints of t(12;14)(q15;q24) have been localized to unusually large genomic regions (approximately 0.5 Mb) on each of the involved chromosomes. In this study, we investigated the molecular events associated with this translocation, specifically the transcription of genes within the breakpoint regions on 14q24 and 12q15. t(12;14)(q15;q24) had previously been associated with activation of HMGA2 on chromosome 12, a gene implicated in promoting cell proliferation, particularly of lipoid tissues. We analyzed this gene and discovered several novel transcripts from 12q15 that are embedded within HMGA2 . On chromosome 14, the breakpoint in one UL was found to lie within RAD51L1 , a putative DNA repair and recombination gene. Subsequent analysis of two additional t(12;14) UL breakpoints refined the chromosome 14 breakpoint region to between 700 and 1200 kb.The large size of the breakpoint regions and the mapping of breakpoints well outside both HMGA2 and RAD51L1 suggested that the translocation may alter the structure and long-range regulatory controls of genes including but perhaps not limited to HMGA2 and RAD51L1 . To test this hypothesis, an expression map was developed which consisted of ESTs and genes within and flanking both breakpoint regions. Expression of these markers was tested in matched normal and t(12;14) ULtissue samples to identify a domain of altered expression on chromosomes 12 and 14. HMGA2 and the three novel ESTs embedded within HMGA2 ., A15, B6, and D12, were overexpressed six- to more than twenty-fold, while RAD51L1 and other ESTs on chromosome 14 were not consistently or significantly altered in UL. Positional cloning of the UL breakpoint region and mapping of the domain of altered expression in tumors sets the stage for understanding the molecular mechanism for the pathogenesis of UL. Advisors/Committee Members: Menon, Dr. Anil G. (Advisor).

Subjects/Keywords: uterine leiomyoma; translocation; gene expression; RAD5161; HMGA2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

INGRAHAM, S. E. (2002). THE BALANCED, RECIPROCAL TRANSLOCATION OF CHROMOSOMAL SUBBANDS 12q15 AND 14q24 AND ALTERED GENE EXPRESSION IN UTERINE LEIOMYOMA. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029433658

Chicago Manual of Style (16^th Edition):

INGRAHAM, SUSAN ELIZABETH. “THE BALANCED, RECIPROCAL TRANSLOCATION OF CHROMOSOMAL SUBBANDS 12q15 AND 14q24 AND ALTERED GENE EXPRESSION IN UTERINE LEIOMYOMA.” 2002. Doctoral Dissertation, University of Cincinnati. Accessed January 19, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029433658.

MLA Handbook (7^th Edition):

INGRAHAM, SUSAN ELIZABETH. “THE BALANCED, RECIPROCAL TRANSLOCATION OF CHROMOSOMAL SUBBANDS 12q15 AND 14q24 AND ALTERED GENE EXPRESSION IN UTERINE LEIOMYOMA.” 2002. Web. 19 Jan 2021.

Vancouver:

INGRAHAM SE. THE BALANCED, RECIPROCAL TRANSLOCATION OF CHROMOSOMAL SUBBANDS 12q15 AND 14q24 AND ALTERED GENE EXPRESSION IN UTERINE LEIOMYOMA. [Internet] [Doctoral dissertation]. University of Cincinnati; 2002. [cited 2021 Jan 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029433658.

Council of Science Editors:

INGRAHAM SE. THE BALANCED, RECIPROCAL TRANSLOCATION OF CHROMOSOMAL SUBBANDS 12q15 AND 14q24 AND ALTERED GENE EXPRESSION IN UTERINE LEIOMYOMA. [Doctoral Dissertation]. University of Cincinnati; 2002. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029433658

George Mason University

14. Gloede, Lise. Diet Quality and Nutritional Intake Differences Between Young Adult and Middle Aged Women with and Without Uterine Fibroids Participating in the National Nutrition and Health Examination Survey (NHANES) 2001-2006 .

Degree: George Mason University

URL: http://hdl.handle.net/1920/10785

► Background: Uterine fibroids are a common condition for many premenopausal women with painful side effects and reproductive ramifications. Treatment options are limited and little is… (more)

▼ Background: Uterine fibroids are a common condition for many premenopausal women with painful side effects and reproductive ramifications. Treatment options are limited and little is known about prevention. Dietary intake and food patterns are modifiable lifestyle factors which may play a role in this condition. Objective: To evaluate differences in dietary patterns, as measured using the Healthy Eating Index (HEI)-2010, and macronutrient intake between women with and without uterine fibroids. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) cycles 2001-2002, 2003-2004, and 2005-2006 was obtained to examine a sample of young adult and middle aged women in the United States, excluding those who were pregnant or breastfeeding. Self-reported dietary intake from one day of 24-hour recalls, anthropometric measurements, reproductive health, and demographic information was collected as part of NHANES. Demographic and reproductive health characteristics were compared between groups using regression and chi-squared tests. HEI-2010 scores and energy adjusted macronutrient intake differences between groups were compared using linear regression adjusting for covariates of age, BMI, race, smoking status, marital status, and educational level. Results: This analysis included 87 women reporting previous uterine fibroid diagnosis and 743 women without a previous diagnosis. Women with fibroids were older (p<0.001), more likely to be college graduates (p=0.05) and be married (p=0.02). After adjustment, no differences in HEI-2010 scores or macronutrient intakes were noted between groups. Subgroup analysis, of women diagnosed only within the past five years, found fibroid diagnosis was associated with an increase in empty calories subcomponent score of 2.53 (95% CI: 1.12, 3.93, p=0.002)) and a decrease in whole fruit subcomponent score of 0.73 (95% CI: -1.44, -0.028, p=0.044) compared to women without a fibroids diagnosis. Conclusion: Women with fibroids did not have significantly different scores in HEI total and subcomponent scores as well as energy adjusted macronutrient intakes. However, women with fibroids diagnosed within the past five years had different scores suggesting differing dietary patterns may be present in women diagnosed more recently, though the subsample size was limited. Due to limitations in this study of use of 1-day of 24-hour recall data, potential misclassification of fibroids, and not controlling for health literacy, further research via prospective cohort studies to examine food intake patterns and possible relationships with uterine fibroids is warranted. Advisors/Committee Members: Gallo, Sina (advisor).

Subjects/Keywords: uterine fibroids; diet quality; Healthy Eating Index; HEI; uterine leiomyoma; NHANES

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gloede, L. (n.d.). Diet Quality and Nutritional Intake Differences Between Young Adult and Middle Aged Women with and Without Uterine Fibroids Participating in the National Nutrition and Health Examination Survey (NHANES) 2001-2006 . (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/10785

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gloede, Lise. “Diet Quality and Nutritional Intake Differences Between Young Adult and Middle Aged Women with and Without Uterine Fibroids Participating in the National Nutrition and Health Examination Survey (NHANES) 2001-2006 .” Thesis, George Mason University. Accessed January 19, 2021. http://hdl.handle.net/1920/10785.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gloede, Lise. “Diet Quality and Nutritional Intake Differences Between Young Adult and Middle Aged Women with and Without Uterine Fibroids Participating in the National Nutrition and Health Examination Survey (NHANES) 2001-2006 .” Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Gloede L. Diet Quality and Nutritional Intake Differences Between Young Adult and Middle Aged Women with and Without Uterine Fibroids Participating in the National Nutrition and Health Examination Survey (NHANES) 2001-2006 . [Internet] [Thesis]. George Mason University; [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1920/10785.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Gloede L. Diet Quality and Nutritional Intake Differences Between Young Adult and Middle Aged Women with and Without Uterine Fibroids Participating in the National Nutrition and Health Examination Survey (NHANES) 2001-2006 . [Thesis]. George Mason University; Available from: http://hdl.handle.net/1920/10785

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

15. Hilário, Sandro Garcia. Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino.

Degree: PhD, Obstetrícia e Ginecologia, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-09082012-164244/ ;

►

OBJETIVO: Avaliar a receptividade endometrial de pacientes submetidas à embolização do mioma uterino, analisando a expressão gênica de LIF, IL-11, IL-6, claudina-4, HoxA-10, HoxA-11, receptor… (more)

▼

OBJETIVO: Avaliar a receptividade endometrial de pacientes submetidas à embolização do mioma uterino, analisando a expressão gênica de LIF, IL-11, IL-6, claudina-4, HoxA-10, HoxA-11, receptor de estrogênio e receptor de progesterona antes e após este procedimento. CASUÍSTICA E MÉTODOS: Foram colhidas biópsias aspirativas de endométrio de 30 pacientes previamente à embolização do mioma uterino e repetida a coleta 3 a 4 meses após este procedimento. A média etária do grupo estudado foi de 36,2 anos. O volume uterino médio pré-embolização foi de 662,1 cc e o pós-embolização foi de 338,2 cc, medidos através de ressonância nuclear magnética. INTERVENÇÃO: As amostras de endométrio foram analisadas pela técnica de RT-PCR para os genes LIF, IL-11, IL-6, claudina-4, HoxA-10, HoxA-11, receptor de estrogênio e receptor de progesterona. RESULTADOS: Dentre os genes estudados, LIF (p=0,005), IL-11 (p=0,001) e HoxA-11 (p=0,021) apresentaram redução estatisticamente significante da expressão no endométrio após a embolização. Os demais genes não apresentaram alteração da expressão estatisticamente significante. CONCLUSÃO: Houve alteração da expressão de genes relacionados à receptividade endometrial, no endométrio de pacientes tratadas pela técnica da embolização do mioma uterino

OBJECTIVE: Assessing endometrial receptivity in patients undergoing uterine fibroid embolization by analyzing the gene expression of LIF, IL-11, IL-6, claudin-4, Hoxa-10, Hoxa-11, estrogen receptor and progesterone receptor before and after this procedure. METHODS: Endometrial aspiration biopsies were collected from 30 patients prior to embolization of uterine myoma, and the collections were repeated 3 to 4 months after this procedure. The average age of the study group was 36.2 years old. The mean uterine volume pre-embolization was 662. 1 cc and post-embolization was 338.2cc as measured by Magnectic Resonance Imaging (MRI). INTERVENTION: Endometrial samples were analyzed by RT-PCR for genes LIF, IL-11, IL-6, claudin-4, Hoxa-10, Hoxa-11, estrogen receptor and progesterone receptor. RESULTS: Among the studied genes, LIF (p=0.005), IL-11 (p=0.001) and Hoxa-11 (p=0.021) showed statistically significant reduction of expression in the endometrium after embolization. The remaining genes showed no statistically significant change in expression. CONCLUSION: There was altered expression of genes related to endometrial receptivity in the endometrium of patients treated by the technique of embolization of uterine myoma

Advisors/Committee Members: Bozzini, Nilo.

Subjects/Keywords: Embolização da artéria uterina; Embryo implantation; Endométrio; Endometrium; Expressão gênica; Gene expression; Implantação do embrião; Leiomioma; Leiomyoma; Polymerase chain reaction; Reação em cadeia da polimerase; Uterine artery embolization

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hilário, S. G. (2012). Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-09082012-164244/ ;

Chicago Manual of Style (16^th Edition):

Hilário, Sandro Garcia. “Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino.” 2012. Doctoral Dissertation, University of São Paulo. Accessed January 19, 2021. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-09082012-164244/ ;.

MLA Handbook (7^th Edition):

Hilário, Sandro Garcia. “Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino.” 2012. Web. 19 Jan 2021.

Vancouver:

Hilário SG. Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Jan 19]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-09082012-164244/ ;.

Council of Science Editors:

Hilário SG. Avaliação da expressão gênica relacionada à receptividade endometrial em pacientes submetidos à embolização do mioma uterino. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-09082012-164244/ ;

Tampere University

16. Rovio, Päivi. Uterine Leiomyomas - Studies on Etiology, Ultrasound Diagnostics and Surgical Treatment .

Degree: Lääketieteen laitos - Medical School, 2008, Tampere University

URL: https://trepo.tuni.fi/handle/10024/67910

► Myoomia eli kohdun hyvänlaatuisia sileälihaskasvaimia esiintyy noin 20- 50 %:lla yli 30- vuotiaista naisista. Nämä kasvaimet vaikuttavat naisen terveyteen ja elämänlaatuun, sillä ne voivat aiheuttaa… (more)

▼ Myoomia eli kohdun hyvänlaatuisia sileälihaskasvaimia esiintyy noin 20- 50 %:lla yli 30- vuotiaista naisista. Nämä kasvaimet vaikuttavat naisen terveyteen ja elämänlaatuun, sillä ne voivat aiheuttaa merkittävää sairastuvuutta, kuten runsaita tai pitkittyneitä kuukautisvuotoja, lantion alueen paine- tai kiputuntemuksia ja myös vaikeuttaa raskaaksi tulemista. Myoomat ja niiden aiheuttamat oireet ovat myös yleisin kohdunpoiston syy. Väitöskirjatyössä pyrittiin tuomaan uusia näkökulmia myoomien syntyyn, luomaan tarkempia myoomien tutkimusmenetelmiä sekä arvioimaan erilaisia leikkaushoitotapoja. Myoomien syntyyn vaikuttavat tekijät ovat vielä epäselvät. Tutkimuksessa selvitettiin kahden eri D- vitamiinijohdannaisen vaikutus myooma- ja kohtulihassolujen kasvuun soluviljelmissä. D- vitamiinin todettiin estävän tehokkaasti näiden solujen kasvua. D- vitamiinin puute saattaa altistaa myoomien kehittymiselle ja kasvulle. Myoomat suurentavat kohdun kokoa ja tämä seikka on merkittävä tekijä valittaessa potilaalle parhaiten soveltuvaa kohdunpoistomenetelmää. Tässä tutkimuksessa kehitettiin uusi matemaattinen kaava, jonka tarkkuus leikkausta edeltävän kohdun kokonaispainon arvioinnissa selvitettiin ultraäänitutkimusta hyödyntäen. Uusi kaava ennusti tarkemmin kohdun todellisen koon kuin aiemmin käytössä ollut perinteinen matemaattinen kaava. Lisäksi toistettavuustutkimus osoitti, ettei tutkijalääkäreiden kokeneisuudella ollut merkitystä mittausten välisissä eroissa kohdun koon arvioinnissa. Pelkkä oireisen myooman poistoleikkaus on tarpeen potilaalle, jonka kohtu halutaan säästää. Tutkimuksessa arvioitiin emättimen pohjukan kautta tehtävän myooman poiston kliinistä tehokkuutta ja turvallisuutta. Leikkaus osoittautui käyttökelpoiseksi vaihtoehdoksi valikoiduille potilaille, jotka toivoivat säilyttävänsä vielä mahdollisuuden raskauksiin. Myös kohdun tähystyksessä tehtävän kohdun limakalvon ja myooman poiston jälkeisiä pitkäaikaistuloksia selvitettiin runsaista kuukautisvuodoista kärsivillä potilailla. Yhdistelmähoito verrattuna pelkkään kohdun limakalvon poistoon ei vaikuttanut merkittävästi kohdunpoistomääriin pitkäaikaisseurannassa. Yhdistelmähoito on varteenotettava kohdunpoistoleikkauksen vaihtoehto valikoiduilla potilailla.; Uterine leiomyomas constitute a substantial health issue for women and these benign tumors represent the most common single indication for hysterectomy. Leiomyomas have a major impact on economic costs and the quality of life of the patient. Vitamin D is a potent anti-proliferative and immunomodulatory secosteroid hormone. Apart from its well-established role in the maintenance of calcium homeostasis, vitamin D modulates cell proliferation, differentiation, cancer invasion and angiogenesis. Despite extensive research on the role of vitamin D in the inhibition of cell growth in a large variety of tissues, there are no reports concerning the possible growth-modulatory effects of vitamin D on benign uterine tumor cells. The first aim of the present study was to assess the potential effect of 1,25(OH)2D3 and…

Subjects/Keywords: Myooma ; D- vitamiini ; kohdun paino ; myooman poisto ; Uterine leiomyoma ; vitamin D ; uterine weight ; myomectomy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rovio, P. (2008). Uterine Leiomyomas - Studies on Etiology, Ultrasound Diagnostics and Surgical Treatment . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/67910

Chicago Manual of Style (16^th Edition):

Rovio, Päivi. “Uterine Leiomyomas - Studies on Etiology, Ultrasound Diagnostics and Surgical Treatment .” 2008. Doctoral Dissertation, Tampere University. Accessed January 19, 2021. https://trepo.tuni.fi/handle/10024/67910.

MLA Handbook (7^th Edition):

Rovio, Päivi. “Uterine Leiomyomas - Studies on Etiology, Ultrasound Diagnostics and Surgical Treatment .” 2008. Web. 19 Jan 2021.

Vancouver:

Rovio P. Uterine Leiomyomas - Studies on Etiology, Ultrasound Diagnostics and Surgical Treatment . [Internet] [Doctoral dissertation]. Tampere University; 2008. [cited 2021 Jan 19]. Available from: https://trepo.tuni.fi/handle/10024/67910.

Council of Science Editors:

Rovio P. Uterine Leiomyomas - Studies on Etiology, Ultrasound Diagnostics and Surgical Treatment . [Doctoral Dissertation]. Tampere University; 2008. Available from: https://trepo.tuni.fi/handle/10024/67910

University of Oulu

17. Uimari, O. (Outi). Epidemiological and familial risk factors of uterine leiomyoma development.

Degree: 2017, University of Oulu

URL: http://urn.fi/urn:isbn:9789526214870

►

Abstract Uterine leiomyomas are the most common benign tumours in females. They are myometrial neoplasms, may present single or multiple, and may be located in… (more)

▼

Abstract Uterine leiomyomas are the most common benign tumours in females. They are myometrial neoplasms, may present single or multiple, and may be located in various sites of the uterus. Leiomyomas distort the uterine cavity and the uterus itself, causing abnormal vaginal bleeding, reduced fertility and also pelvic pressure and pain symptoms. The aim of this study was to elaborate current knowledge on familial uterine leiomyomas and to explore the possible association between uterine leiomyoma and cardiovascular disease risk factors, and also the association between leiomyomas and endometriosis. The natural history of familial uterine leiomyoma study showed significant differences between familial and non-familial leiomyoma cases, familial cases having more severe clinical characteristics. They presented with multiple uterine leiomyomas and were more often symptomatic. They were also diagnosed at a younger age. The prevalence study on uterine leiomyomas and endometriosis offered confirmation of an association between the diseases. Uterine leiomyomas and endometriosis seem to decrease female fertility independently of each other. Uterine leiomyomas related to the hereditary leiomyomatosis and renal cell cancer (HLRCC) tumour syndrome were studied in regard to their clinical characteristics and immunophenotype. The study provided evidence that women with HLRCC may be identified through distinct leiomyoma clinical characteristics, and routine-use IHC of CD34 and Bcl-2. Distinguishing these leiomyoma cases from sporadic ones may identify families affected by fumarate hydratase (fumarase, FH) mutation. Uterine leiomyoma and cardiovascular disease risk factors were studied in The Northern Finland Birth Cohort 1966 (NFBC1966). The study showed an association between leiomyomas and raised cardiovascular disease risk factors, serum lipids and metabolic syndrome in particular. These findings may suggest that there are shared predisposing factors underlying both uterine leiomyomas and adverse metabolic and cardiac disease risks, or that metabolic factors have a role in biological mechanisms underlying leiomyoma development. This study provides novel information on clinical characteristics of familial uterine leiomyomas and on the immunophenotype of HLRCC-related leiomyomas. The study also offers significant confirmation of associations between uterine leiomyomas and both endometriosis and several CVD risk factors.

Tiivistelmä Kohdun leiomyoomat ovat naisten yleisin hyvänlaatuinen kasvain. Ne ovat myometriumin neoplastisia muutoksia ja ne ilmenevät joko yksittäisinä tai monilukuisina, ja ne voivat sijaita missä tahansa kohdun myometriumia. Leiomyoomat muuttavat kohdun ja kohtuontelon säännöllistä muotoa. Lisäksi ne aiheuttavat vuotohäiriöitä, alentunutta hedelmällisyyttä, ja lantion alueen painetta ja kipua. Tämän tutkimuksen tavoitteena oli laajentaa nykyistä tietämystä suvuittain esiintyvistä kohdun leiomyoomista ja selvittää mahdollista leiomyoomien ja kardiovaskulaaritautiriskin assosiaatiota, ja lisäksi selvittää…

Advisors/Committee Members: Ryynänen, M. (Markku), Järvelä, I. (Ilkka).

Subjects/Keywords: cardiovascular risk; endometriosis; epidemiology; familial; glucose metabolism; lipid metabolism; natural history; population-based birth cohort studies; subfertility; uterine leiomyoma/fibroids; alentunut hedelmällisyys; endometrioosi; epidemiologia; familiaalinen; glukoosimetabolia; kardiovaskulaaririski; kohdun leiomyooma; lipidimetabolia; taudinkulku; väestopohjaiset syntymäkohorttitutkimukset; Bcl-2; CD34; FH; HLRCC

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Uimari, O. (. (2017). Epidemiological and familial risk factors of uterine leiomyoma development. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789526214870

Chicago Manual of Style (16^th Edition):

Uimari, O (Outi). “Epidemiological and familial risk factors of uterine leiomyoma development.” 2017. Doctoral Dissertation, University of Oulu. Accessed January 19, 2021. http://urn.fi/urn:isbn:9789526214870.

MLA Handbook (7^th Edition):

Uimari, O (Outi). “Epidemiological and familial risk factors of uterine leiomyoma development.” 2017. Web. 19 Jan 2021.

Vancouver:

Uimari O(. Epidemiological and familial risk factors of uterine leiomyoma development. [Internet] [Doctoral dissertation]. University of Oulu; 2017. [cited 2021 Jan 19]. Available from: http://urn.fi/urn:isbn:9789526214870.

Council of Science Editors:

Uimari O(. Epidemiological and familial risk factors of uterine leiomyoma development. [Doctoral Dissertation]. University of Oulu; 2017. Available from: http://urn.fi/urn:isbn:9789526214870

Université Paris-Sud – Paris XI

18. Violet, Pierre-Christian. Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins : Role of lipid phosphate phosphatases in the modulation of signaling pathways in uterine leiomyoma.

Degree: Docteur es, Biochimie, Biologie Cellulaire et Moléculaire, 2012, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2012PA11T083

►

Le léiomyome utérin est la pathologie utérine la plus fréquente chez les femmes en âges de procréer. Des résultats précédent obtenus avec les cellules ELT3,… (more)

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Le léiomyome utérin est la pathologie utérine la plus fréquente chez les femmes en âges de procréer. Des résultats précédent obtenus avec les cellules ELT3, une lignée de cellules de léiomyomes de rat, ont montré que l’acide lysophosphatidique (LPA) activait les MAP kinases ERK1/2 via le récepteur LPA1 couplé à la protéine Gi et l’activation de Raf, Ras et de MEK. Durant ce travail, nous avons caractérisé l’activité phosphatase responsable de la dégradation du LPA dans cette lignée de cellules ELT3. Nous avons montré que le LPA était dégradé exclusivement par la lipide-phosphate phosphatase 1 (LPP1), seule isoforme exprimé dans les cellules ELT3. Dans un deuxième temps nous nous somme intéressés aux effets du diacylglycerol pyrophosphate (DGPP). Le DGPP est un médiateur lipidique qui, sous sa forme dioctanoyl (DGPP8:0), est décrit comme un antagoniste des récepteurs LPA1 et LPA3 chez les mammifères. Dans cette étude, nous montrons que le DGPP8:0 n’a pas d’effet antagoniste sur l’activation du module MAP kinase ERK1/2 par le LPA mais qu’il induit une activation de ERK1/2 dans plusieurs lignées de cellules de mammifères. En effet le DGPP active ERK1/2 à travers l’activation des PKC, Raf et MEK. De plus, nous montrons que l’activation induite par le DGPP repose sur sa déphosphorylation catalysée par une LPP. Nous montrons également que l’inhibition de LPP1 par le VPC32183 ou l’utilisation de siRNA dirigé contre la lipide phosphate-phosphatase 1 (LPP1) réduit l’activation ERK1/2 induite par le DGPP. Ceci montre que le DGPP active ERK1/2 via sa déphosphorylation en acide phosphatidique (PA8:0), catalysée par la LPP1. Enfin dans une dernière partie nous montrons que le myomètre sain, contrairement aux cellules ELT3, exprime à la fois la LPP1 et la LPP3. En étudiant l’effet de la surexpression de la LPP3 dans les cellules ELT3, nous avons observé que la LPP3 interagissait avec la LPP1 et qu’elle pourrait la séquestrer dans des compartiments membranaires internes. Cette séquestration entraine une diminution de l’actvité ecto-LPP au profit de l’activité intracellulaire qui pourrait réguler négativement la production de seconds messagers phospholipidiques. Ces résultats montrent l’importance des LPP dans la régulation des effets des phospholipides bioactifs et suggère un lien entre le caractère tumorale des cellules de léiomyomes et l’absence de la LPP3.

Leiomyoma is the most common uterine disease in women in age of procreation. Previous result have shown that in ELT3 cells, which is a rat leiomyoma-derived cell line, lysophosphatidic acid (LPA) was able to activate ERK1/2 MAP kinases through the activation of the LPA1 receptor via the classical MAP kinase pathway involving Raf, Ras and MEK. We have observed that LPA was dephosphorylated in ELT3 cells by Lipid-phosphate phosphatase 1 (LPP1) which is the only LPP isoform expressed in these cells. In a second part, we investigated the effect of diacylglycerol pyrophosphate (DGPP). DGPP, in its octanoyl form (DGPP8:0), is described as an LPA1, 3-antognist. Here, we show that…

Advisors/Committee Members: Robin, Philippe (thesis director).

Subjects/Keywords: Leiomyome utérin; Cellule ELT3; Lipide-phosphate phosphatase; Acide phosphatidique; Acide lysophophatidique; Diacylglycérol pyrophosphate; VPC32183; Endothèline; ERK; MAP kinase; Uterine Leiomyoma; ELT3 cells; Lipid-phosphate phosphatase; Phosphatidic acid; Lysophosphatidic acid; Diacylglycerol pyrophosphate; VPC32183; EndothEline; ERK; MAP kinase

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Violet, P. (2012). Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins : Role of lipid phosphate phosphatases in the modulation of signaling pathways in uterine leiomyoma. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2012PA11T083

Chicago Manual of Style (16^th Edition):

Violet, Pierre-Christian. “Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins : Role of lipid phosphate phosphatases in the modulation of signaling pathways in uterine leiomyoma.” 2012. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed January 19, 2021. http://www.theses.fr/2012PA11T083.

MLA Handbook (7^th Edition):

Violet, Pierre-Christian. “Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins : Role of lipid phosphate phosphatases in the modulation of signaling pathways in uterine leiomyoma.” 2012. Web. 19 Jan 2021.

Vancouver:

Violet P. Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins : Role of lipid phosphate phosphatases in the modulation of signaling pathways in uterine leiomyoma. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2012. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2012PA11T083.

Council of Science Editors:

Violet P. Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins : Role of lipid phosphate phosphatases in the modulation of signaling pathways in uterine leiomyoma. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2012. Available from: http://www.theses.fr/2012PA11T083

Texas Medical Center

19. Greathouse, Kristen L. XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT.

Degree: PhD, 2010, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/51

► Environmental exposures during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life in a process known as developmental… (more)

▼ Environmental exposures during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life in a process known as developmental reprogramming. We have shown that neonatal exposure to the xenoestrogen diethylstilbestrol (DES) can developmentally reprogram the reproductive tract in genetically susceptible Eker rats giving rise to complete penetrance of uterine leiomyoma. Based on this, we hypothesized that xenoestrogens, including genistein (GEN) and bisphenol A (BPA), reprogram estrogen-responsive gene expression in the myometrium and promote the development of uterine leiomyoma. We proposed the mechanism that is responsible for the developmental reprogramming of gene expression was through estrogen (E2)/ xenoestrogen inducedrapid ER signaling, which modifies the histone methyltransferase Enhancer of Zeste homolog 2 (EZH2) via activation of the PI3K/AKT pathway. We further hypothesized that there is a xenostrogen-specific effect on this pathway altering patterns of histone modification, DNA methylation and gene expression. In addition to our novel finding that E2/DES-induced phosphorylation of EZH2 by AKT reduces the levels of H3K27me3 in vitro and in vivo, this work demonstrates in vivo that a brief neonatal exposure to GEN, in contrast to BPA, activates the PI3K/AKT pathway to regulate EZH2 and decreases H3K27me3 levels in the neonatal uterus. Given that H3K27me3 is a repressive mark that has been shown to result in DNA methylation and gene silencing we investigated the methylation of developmentally reprogrammed genes. In support of this evidence, we show that neonatal DES exposure in comparison to VEH, leads to hypomethylation of the promoter of a developmentally reprogrammed gene, Gria2, that become hyper-responsive to estrogen in the adult myometrium indicating vi that DES exposure alter gene expression via chromatin remodeling and loss of DNA methylation. In the adult uterus, GEN and BPA exposure developmentally reprogrammed expression of estrogen-responsive genes in a manner opposite of one another, correlating with our previous data. Furthermore, the ability of GEN and BPA to developmental reprogram gene expression correlated with tumor incidence and multiplicity. These data show that xenoestrogens have unique effects on the activation of non-genomic signaling in the developing uterus that promotes epigenetic and genetic alterations, which are predictive of developmental reprogramming and correlate with their ability to modulate hormone-dependent tumor development. Advisors/Committee Members: Cheryl L. Walker, Ph.D., David Johnson, Ph.D., Stephen Hursting, Ph.D., M.P.H..

Subjects/Keywords: Xenoestrogens; developmental reprogramming; uterine leiomyoma; epigenetics; non-genomic signaling; estrogen receptor; Cancer Biology; Developmental Biology; Molecular Biology; Other Pharmacology, Toxicology and Environmental Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Greathouse, K. L. (2010). XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/51

Chicago Manual of Style (16^th Edition):

Greathouse, Kristen L. “XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT.” 2010. Doctoral Dissertation, Texas Medical Center. Accessed January 19, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/51.

MLA Handbook (7^th Edition):

Greathouse, Kristen L. “XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT.” 2010. Web. 19 Jan 2021.

Vancouver:

Greathouse KL. XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT. [Internet] [Doctoral dissertation]. Texas Medical Center; 2010. [cited 2021 Jan 19]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/51.

Council of Science Editors:

Greathouse KL. XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT. [Doctoral Dissertation]. Texas Medical Center; 2010. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/51

University of Illinois – Urbana-Champaign

20. Mesquita, Fernando S. Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways.

Degree: PhD, 0002, 2010, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/15577

► Reactive oxygen species have received an increasing amount of attention over the past decade, not only due to their role in oxidative damage, but also… (more)

▼ Reactive oxygen species have received an increasing amount of attention over the past decade, not only due to their role in oxidative damage, but also because of their participation as second messengers on the relay of many signaling pathways and their role in the development of numeours fibrotic diseases. This Ph.D. dissertation focused on testing the hypothesis that ROS are necessary components of the EGF and PDGF pathways in leiomyoma and normal myometrial SMCs. The main findings of this work were: 1) leiomyoma smooth muscle cells (LSMCs) and myometrial smooth muscle cells (MSMCs) produce ROS in response to EGF and PDGF; 2) ROS are necessary for EGF- and PDGF-induced LSMCs and MSMCs proliferation, and sufficient to induce LSMCs proliferation; 3) ROS are necessary and sufficient to induce a fraction of Erk1/2 activation in LSMCs and MSMCs; 4) NADPH oxidase components are expressed in leiomyoma and normal myometrial tissue; 5) PDGF induces translocation of p47phox into lipid rafts in LSMCs; 6) PKC mediates Erk1/2 activation by PDGF in MSMCs and LSMCs; 7) PKC activation alone is sufficient to induce ROS production in MSMCs and LSMCs; 8) hydrogen peroxide inhibits the activity of PTPases in LSMCs; 9) regulation of PTPase activity is important for myometrial and leiomyoma SMC proliferation. The findings suggest that ROS are necessary components of the EGF and PDGF pathways. There is also evidence that NADPH oxidase complex is the source of EGF and PDGF-induced ROS production, and that the mechanism of activation of this complex involves translocation of the subunit p47phox into lipid rafts as well as PKC activity. Furthermore, ROS might be acting by regulating protein tyrosine phosphatase enzymes, which in turn affect the proliferation of leiomyoma and myometrial SMCs. Based on the results obtained from my work I speculate that a subset of leiomyoma tumors may originate from a growth advantage acquired by myometrial SMCs that overexpress NADPH oxidase components leading to tumor development. Advisors/Committee Members: Nowak, Romana A. (advisor), Nowak, Romana A. (Committee Chair), Bunick, David (committee member), Miller, David J. (committee member), Bagchi, Indrani C. (committee member), Bahr, Janice M. (committee member).

Subjects/Keywords: Leiomyoma; uterine fibroid; NADPH oxidase; Platelet-derived growth factor (PDGF); Epidermal growth factor (EGF); Nicotinamide adenine dinucleotide phosphate (NADPH); Reactive oxygen species (ROS); tyrosine phosphatase; smooth muscle cells

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mesquita, F. S. (2010). Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/15577

Chicago Manual of Style (16^th Edition):

Mesquita, Fernando S. “Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways.” 2010. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 19, 2021. http://hdl.handle.net/2142/15577.

MLA Handbook (7^th Edition):

Mesquita, Fernando S. “Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways.” 2010. Web. 19 Jan 2021.

Vancouver:

Mesquita FS. Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2010. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2142/15577.

Council of Science Editors:

Mesquita FS. Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2010. Available from: http://hdl.handle.net/2142/15577

Open Access Theses and Dissertations