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University of Melbourne
1.
THORNTON, THERESE.
The effect of acupuncture on upper airway function and physiology in obstructive sleep apnoea.
Degree: 2017, University of Melbourne
URL: http://hdl.handle.net/11343/212142 
► Obstructive sleep apnoea (OSA) involves repetitive obstruction of the upper airway during sleep. Continuous positive airway pressure (CPAP) is the most common treatment, however, many…
(more)
▼ Obstructive sleep apnoea (OSA) involves repetitive obstruction of the upper airway during sleep. Continuous positive airway pressure (CPAP) is the most common treatment, however, many patients cannot tolerate CPAP and adherence rates are low. Recent research has suggested that acupuncture can reduce the severity of OSA. The past research, while promising did not conform to normal Chinese medicine (CM) practice as the researchers failed to diagnose CM syndromes in their patient sample nor design their treatment based on CM syndrome analysis. It was also not possible to rule out potential confounding effects of the sham treatment, as the method employed was not guaranteed to be biologically inert. The aim of the present study was to address these limitations and determine whether acupuncture is an effective alternative treatment for OSA, and to identify underlying physiological changes as a result of acupuncture treatment. Initially, 39 patients admitted for investigative PSG to diagnose OSA underwent standard CM diagnostic procedures to identify common CM syndromes in the OSA population. Four CM phenotypes of OSA were identified and the most common phenotype (occurring in >44% of the sampled population) was then incorporated into the inclusion criteria for the clinical trial of acupuncture treatment. The acupuncture treatment employed was also designed to target the CM phenotype pathology. Further, the sham method employed in the present study, was also guaranteed to be biologically inert. Twenty OSA patients were randomly assigned to receive either 12 weeks of active needle acupuncture (n=10 (3 F); mean age=56.3 years) or sham laser acupuncture (n=10 (3 F); mean age=45.3 years) treatments. Prior to and following the treatment period subjects underwent detailed polysomnography, including measurement of epiglottic pressure, calibrated airflow and genioglossus muscle activity. In addition, subjective health and wellbeing, sleepiness and mood were assessed. AHI, waking nasopharyngeal resistance, ventilation, arousal threshold and genioglossus muscle activity were analysed while blinded to treatment type and study time. One participant was excluded due to an insufficient amount of sleep for analysis. There was no significant effect of treatment type on pre- and post-treatment measurement of NREM AHI (mean pre-treatment: active= 38.10, sham=26.44; mean post-treatment: active=38.83; sham=37.06 events/hour) or NREM AI (mean pre-treatment: active=57.71, sham=49.03; mean post-treatment: active=58.98, sham=58.60 events/hour). There were no significant differences within the active or sham groups, nor between groups across time for the subjective questionnaires. All upper airway physiology measurements made during NREM sleep were also unchanged following both sham and active acupuncture treatment. The data indicates that there are no differences between active- versus sham-acupuncture on subjective health and wellbeing, sleepiness, or mood, nor their AHI or upper airway function and physiology in a clinical OSA…
Subjects/Keywords: OSA; acupuncture; upper airway
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APA (6th Edition):
THORNTON, T. (2017). The effect of acupuncture on upper airway function and physiology in obstructive sleep apnoea. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/212142
Chicago Manual of Style (16th Edition):
THORNTON, THERESE. “The effect of acupuncture on upper airway function and physiology in obstructive sleep apnoea.” 2017. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021.
http://hdl.handle.net/11343/212142.
MLA Handbook (7th Edition):
THORNTON, THERESE. “The effect of acupuncture on upper airway function and physiology in obstructive sleep apnoea.” 2017. Web. 28 Feb 2021.
Vancouver:
THORNTON T. The effect of acupuncture on upper airway function and physiology in obstructive sleep apnoea. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11343/212142.
Council of Science Editors:
THORNTON T. The effect of acupuncture on upper airway function and physiology in obstructive sleep apnoea. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/212142
Addis Ababa University
2.
GTACHEW, METAFERIA.
A STUDY ON THE ASSESMENT OF THE MAGNITUDE THE CAUSES AND OUTCOMES OF ACUTE UPPER AIRWAY OBESTRUCTION AMONG CHILDREN AT BLACK LION SPECIALIZED HOSPITAL DEPARTMENT OF PEDIATANDCHILDHEALTH
.
Degree: 2014, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/5838
► Background: Acute upper airway obstruction is a common cause of respiratory emergencies among children. However, the magnitude, the causes, and the outcomes of acute upper…
(more)
▼ Background:
Acute
upper airway obstruction is a common cause of respiratory emergencies among children. However, the magnitude, the causes, and the outcomes of acute
upper airway obstruction in Ethiopia are not studied and documented.
Objective: To determine the magnitude, the causes, and the outcomes of Acute
Upper Airway Obstruction among pediatric patients who visited the pediatric emergency department of Tikur Anbessa Specialized Hospital.
Methodology: Retrospective record review based on the institutional record of children who had Acute
upper airway obstruction and visited the pediatric emergency unit over a one year period was conducted in Tikur Anbessa Specialized Hospital between July 2012 to June 2013 relevant data were collected from institutional records of all children visited the pediatric emergency unit due to Acute
upper air way obstruction. Major causes of Acute
upper air way obstruction were identified and its outcomes were determined. SPSS version-16 was used to verify the association between selected socio demographic characteristics and clinical conditions with the outcome of Acute
upper air way obstruction.
Result:. During the study period 2,327 children have visited the pediatrics emergency OPD due to different problems. Among which 161 (6.9%) children were presented with acute
upper airway obstruction. Croup was found to be the most common cause of Acute
upper airway obstruction(75.8%)followed by foreign body aspiration(9.9%). Majority of the patients (68.9%) were treated at the emergency OPD and sent home with improvement after they were kept for few hours for observation. The study also revealed that 7(4.%)Patients were died of Acute
upper airway obstruction. Statistically significant association was not observed between socio demographic characteristics, clinical conditions and the outcome of
upper air way obstruction.
Conclusion and Recommendation
On average, at least three children with Acute
upper airway obstruction visited the emergency OPD per week during the study period. The causes of acute
upper airway obstruction were varied although infectious diseases (croup, bacterial tracheitis, retropharyngeal abscess, and peritonsillar abscess) were responsible for the majority of the cases (82.6%). Seven patients died of
upper airway obstruction during the study period. Therefore, improving the Acute
upper air way obstruction diagnosis and management capacity of health workers and the clinical set up of the pediatric emergency unit is crucial to provide an immediate and aggressive response.
Advisors/Committee Members: MULUWORK TEFERA (ASSISTANT PROFESSOR OF PEDIATRICS) (advisor).
Subjects/Keywords: Acute Upper Airway; Obstruction; pediatric patients
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APA (6th Edition):
GTACHEW, M. (2014). A STUDY ON THE ASSESMENT OF THE MAGNITUDE THE CAUSES AND OUTCOMES OF ACUTE UPPER AIRWAY OBESTRUCTION AMONG CHILDREN AT BLACK LION SPECIALIZED HOSPITAL DEPARTMENT OF PEDIATANDCHILDHEALTH
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5838
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
GTACHEW, METAFERIA. “A STUDY ON THE ASSESMENT OF THE MAGNITUDE THE CAUSES AND OUTCOMES OF ACUTE UPPER AIRWAY OBESTRUCTION AMONG CHILDREN AT BLACK LION SPECIALIZED HOSPITAL DEPARTMENT OF PEDIATANDCHILDHEALTH
.” 2014. Thesis, Addis Ababa University. Accessed February 28, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/5838.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
GTACHEW, METAFERIA. “A STUDY ON THE ASSESMENT OF THE MAGNITUDE THE CAUSES AND OUTCOMES OF ACUTE UPPER AIRWAY OBESTRUCTION AMONG CHILDREN AT BLACK LION SPECIALIZED HOSPITAL DEPARTMENT OF PEDIATANDCHILDHEALTH
.” 2014. Web. 28 Feb 2021.
Vancouver:
GTACHEW M. A STUDY ON THE ASSESMENT OF THE MAGNITUDE THE CAUSES AND OUTCOMES OF ACUTE UPPER AIRWAY OBESTRUCTION AMONG CHILDREN AT BLACK LION SPECIALIZED HOSPITAL DEPARTMENT OF PEDIATANDCHILDHEALTH
. [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Feb 28].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/5838.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
GTACHEW M. A STUDY ON THE ASSESMENT OF THE MAGNITUDE THE CAUSES AND OUTCOMES OF ACUTE UPPER AIRWAY OBESTRUCTION AMONG CHILDREN AT BLACK LION SPECIALIZED HOSPITAL DEPARTMENT OF PEDIATANDCHILDHEALTH
. [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5838
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
金住, 雅彦.
Surface electromyography of accessory inspiratory muscle activity during upper airway obstruction : 表面筋電図解析による上気道閉塞時の吸気補助筋活動の検討.
Degree: 博士（歯学）, 2016, Osaka Dental University / 大阪歯科大学
URL: http://id.nii.ac.jp/1392/00000012/
► In a previous study, we examined how changes in breathing pattern affect the electromyographic (EMG) activity of accessory inspiratory muscles during spontaneous breathing. The present…
(more)
▼ In a previous study, we examined how changes in breathing pattern affect the electromyographic (EMG) activity of accessory inspiratory muscles during spontaneous breathing. The present study aimed to create a device that simulates progressive upper airway obstruction to examine how such obstruction relates to EMG changes and respiratory movement. The subjects were 8 men and women between 26 and 47 years of age with normal cardiopulmonary function. A two-in-one airway pressure and flow monitor mask and a pulse oximeter were secured to the subjects, and electrodes were placed bilaterally on the sternocleidomastoid muscles. A heat and moisture exchange filter was attached to the tip of the airway pressure and flow monitor, and 1 mL/min of 2% methylcellulose solution was injected into the filter using a syringe pump. As airway resistance gradually increased over time, changes in accessory inspiratory muscle activity, airway pressure, expiratory flow, and percutaneous oxygen saturation were measured. Following spike count processing, changes in the spike count were calculated at one-minute intervals. Spike counts for the intervals between 5 and 6 minutes and 6 and 7 minutes were significantly greater than for the other intervals. Whereas the average airway pressure among all subjects increased over time, and increased significantly starting from the interval between 4 and 5 minutes, expiratory flow significantly decreased starting from this same interval. SpO_2 started to decrease from the interval between 5 and 6 minutes and was significantly lower over the next interval. These findings indicate that the sternocleidomastoid muscle may be actively recruited as an accessory inspiratory muscle during inspiratory movement associated with increased airway resistance. Furthermore, given the significant EMG changes observed before SpO_2 decreased, electromyography may be a more sensitive monitoring method of upper airway obstruction than pulse oximetry.
2014年度
Subjects/Keywords: Surface electromyography; Sternocleidomastoid muscle; Inspiratory muscle; Upper airway obstruction; Surface electromyography; Sternocleidomastoid muscle; Inspiratory muscle; Upper airway obstruction
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APA (6th Edition):
金住, . (2016). Surface electromyography of accessory inspiratory muscle activity during upper airway obstruction : 表面筋電図解析による上気道閉塞時の吸気補助筋活動の検討. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000012/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
金住, 雅彦. “Surface electromyography of accessory inspiratory muscle activity during upper airway obstruction : 表面筋電図解析による上気道閉塞時の吸気補助筋活動の検討.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed February 28, 2021.
http://id.nii.ac.jp/1392/00000012/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
金住, 雅彦. “Surface electromyography of accessory inspiratory muscle activity during upper airway obstruction : 表面筋電図解析による上気道閉塞時の吸気補助筋活動の検討.” 2016. Web. 28 Feb 2021.
Vancouver:
金住 . Surface electromyography of accessory inspiratory muscle activity during upper airway obstruction : 表面筋電図解析による上気道閉塞時の吸気補助筋活動の検討. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2021 Feb 28].
Available from: http://id.nii.ac.jp/1392/00000012/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
金住 . Surface electromyography of accessory inspiratory muscle activity during upper airway obstruction : 表面筋電図解析による上気道閉塞時の吸気補助筋活動の検討. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000012/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Pretoria
4.
Mirazo Michelena, Javier E.
Use of
overground endoscopy for detection of upper airway abnormalities in
Thoroughbred racehorses in South Africa.
Degree: Companion Animal Clinical
Studies, 2013, University of Pretoria
URL: http://hdl.handle.net/2263/36797
► Upper airway endoscopy at rest has been the diagnostic method of choice for diagnosing equine upper respiratory tract (URT) disease since its development in the…
(more)
▼ Upper airway endoscopy at rest has been the diagnostic
method of choice for diagnosing equine
upper respiratory tract
(URT) disease since its development in the 1970´s. The development
of high-speed treadmill endoscopy (HSTE) improved the sensitivity
of URT endoscopy by allowing the examiner to observe the horse’s
nasopharynx and larynx during exercise. However, the level of
exertion achieved during HSTE may not always represent that
achieved during normal exercise as surface, rider, tack, and
environmental variables are altered. Recently, the development of
dynamic overground endoscopy (DOE) has addressed some of those
shortcomings.
A retrospective study was undertaken to describe the
upper airway abnormalities detected during DOE in horses presenting
with poor performance and/or abnormal respiratory noise in South
Africa. Patient records of Thoroughbred racehorses undergoing DOE
from November 2011 to August 2012 by the Onderstepoort Veterinary
Academic Hospital were reviewed. Data collected included
signalment, primary complaint, distance exercised, maximum speed
attained, and dynamic
airway abnormalities detected. XIII
A second
study was carried out to evaluate agreement within and among
examiners of three grading systems for laryngeal function at
exercise. The grading systems assessed were an existing system for
grading axial deviation of aryepiglottic folds (ADAF), a modified
system for grading recurrent laryngeal neuropathy (RLN) at
exercise, and a proposed system for grading vocal cord collapse
(VCC). For investigation of intra-observer variability, recordings
were watched by two of the investigators at the same time, on two
different occasions, in real time, slow motion, and at
frame-by-frame speed. To evaluate inter-observer variability,
recordings were watched by four investigators on one occasion, as
described for investigation of intra-observer variability, and
scoring sheets completed. Kappa agreement was calculated for both
intra- and inter-observer sessions.
Fifty-two horses that
underwent DOE for investigation of poor performance and/or abnormal
respiratory noise were identified. The main abnormalities detected
included dorsal displacement of the soft palate (DDSP) (13/52
horses, 25%); recurrent laryngeal neuropathy (RLN) (17/52 horses,
33%); axial deviation of the aryepiglottic folds (ADAF) (21/52
horses, 40%) and vocal cord collapse (VCC) (18/52 horses, 35%). A
total of 40 horses presented one or more abnormalities of the URT
(77%). Fifteen horses (29%) had a single abnormality, and 25 horses
(48%) had multiple abnormalities. Results at frame-by-frame speed
from the intra-observer evaluations for all the conditions showed
substantial agreement for RLN by both observers (K = 74 - 80).
Intra-observer evaluations for VCC were moderate to substantial (K
53 – 63). ADAF was the most difficult URT abnormality to assess for
both observers, and agreement within observers was only fair to
moderate (K = 36 - 52). Inter-observer evaluations for RLN showed
substantial to moderate agreement (K = 62).…
Advisors/Committee Members: Lyle, C. M. (advisor), Page, Patrick Collin (coadvisor).
Subjects/Keywords: Upper
airway endoscopy; Upper
respiratory tract disease (URT);
Thoroughbred horse; Race
horses;
DOE;
UCTD
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APA ·
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Manager
APA (6th Edition):
Mirazo Michelena, J. E. (2013). Use of
overground endoscopy for detection of upper airway abnormalities in
Thoroughbred racehorses in South Africa. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/36797
Chicago Manual of Style (16th Edition):
Mirazo Michelena, Javier E. “Use of
overground endoscopy for detection of upper airway abnormalities in
Thoroughbred racehorses in South Africa.” 2013. Masters Thesis, University of Pretoria. Accessed February 28, 2021.
http://hdl.handle.net/2263/36797.
MLA Handbook (7th Edition):
Mirazo Michelena, Javier E. “Use of
overground endoscopy for detection of upper airway abnormalities in
Thoroughbred racehorses in South Africa.” 2013. Web. 28 Feb 2021.
Vancouver:
Mirazo Michelena JE. Use of
overground endoscopy for detection of upper airway abnormalities in
Thoroughbred racehorses in South Africa. [Internet] [Masters thesis]. University of Pretoria; 2013. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/2263/36797.
Council of Science Editors:
Mirazo Michelena JE. Use of
overground endoscopy for detection of upper airway abnormalities in
Thoroughbred racehorses in South Africa. [Masters Thesis]. University of Pretoria; 2013. Available from: http://hdl.handle.net/2263/36797
RMIT University
5.
Mohammad Rasani, M.
Numerical modelling of fluid-structure interactions for fluid-induced instability in the upper airway.
Degree: 2012, RMIT University
URL: http://researchbank.rmit.edu.au/view/rmit:160125
► This study is concerned with fluid-structure interactions (FSI) involved in the human upper airway, in particular, those associated with snoring and obstructive sleep apnoea/hypopnoea syndrome…
(more)
▼ This study is concerned with fluid-structure interactions (FSI) involved in the human upper airway, in particular, those associated with snoring and obstructive sleep apnoea/hypopnoea syndrome (OSAHS). Further examining this area of interest, the goal of the current research is to contribute further understanding and enhance development of computational modelling, for retroglossal obstruction and palatal snoring. To that end, the investigation was divided into three major parts. Firstly, extending previous laminar, 2-D reduced Navier-Stokes model, an idealised 3-D computational model was constructed for studying retroglossal obstruction. A full Navier-Stokes solver in an Arbitrary Lagrangian-Eulerian (ALE) framework was coupled to a linear thin shell, where both laminar and turbulent flow was investigated. Numerical results showed increase flow-induced tongue replica deflection under turbulent conditions and demonstrated cross-flow pressures that may encourage side wall collapse. In the second part of the thesis, palatal snoring was further examined and its potential to detect retroglossal obstruction was proposed. In order to investigate this, flow-induced instability of a cantilever plate in an obstructed channel was modeled and a relationship between critical velocity and obstruction depth was established. Correlating the critical velocity with typical breathing flow curve, a time difference between palatal snoring episodes or onset of palatal snoring, may represent a key variable for non-invasive measurement of retroglossal obstruction severity. Further enhancement of the 2-D computational model by including contact was proposed using an immersed boundary method (IBM). This may represent a more complete model of palatal snoring by modelling pre- and post-contact response of unstable cantilever plate, which showed potential to capture more complicated palatal snoring signals. Finally, the third part of this thesis examined flow-induced instability of a soft palate in a 3-D realistic upper airway. To model this, a full 3-D Navier-Stokes solver under an ALE framework was coupled to a non-linear soft palate model. Appropriate soft palate properties were applied giving palatal snoring frequency within range of clinically measured values. Palatal flutter was observed at high flow rates, demonstrating irreversible transfer of flow energy to soft palate. This computational model may perhaps be exploited for future investigation of more accurate palatal snoring, necessary for developing non-invasive snoring signals for measurement or diagnosis of retroglossal obstruction.
Subjects/Keywords: Fields of Research; Flow-Induced Instability; Snoring; Sleep Apnoea; Upper Airway
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APA (6th Edition):
Mohammad Rasani, M. (2012). Numerical modelling of fluid-structure interactions for fluid-induced instability in the upper airway. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:160125
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mohammad Rasani, M. “Numerical modelling of fluid-structure interactions for fluid-induced instability in the upper airway.” 2012. Thesis, RMIT University. Accessed February 28, 2021.
http://researchbank.rmit.edu.au/view/rmit:160125.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mohammad Rasani, M. “Numerical modelling of fluid-structure interactions for fluid-induced instability in the upper airway.” 2012. Web. 28 Feb 2021.
Vancouver:
Mohammad Rasani M. Numerical modelling of fluid-structure interactions for fluid-induced instability in the upper airway. [Internet] [Thesis]. RMIT University; 2012. [cited 2021 Feb 28].
Available from: http://researchbank.rmit.edu.au/view/rmit:160125.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mohammad Rasani M. Numerical modelling of fluid-structure interactions for fluid-induced instability in the upper airway. [Thesis]. RMIT University; 2012. Available from: http://researchbank.rmit.edu.au/view/rmit:160125
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
石坂, 哲.
A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation With Jaw Closure in Normal Subjects Under Propofol Anesthesia : プロポフォール麻酔下における健常者の上気道の閉塞は、遠隔制御エアバッグ装置による頭蓋部の上昇と顎閉鎖によって改善することができる.
Degree: 博士(歯学), 2014, Nagasaki University / 長崎大学
URL: http://hdl.handle.net/10069/35787
► Continuous maintenance of an appropriate position of the mandible and head purely by manual manipulation is dif cult, although the maneuver can restore airway patency…
(more)
▼ Continuous maintenance of an appropriate position of the mandible and head purely by manual manipulation is dif cult, although the maneuver can restore airway patency during sleep and anesthesia. The aim of this paper was to examine the effect of head elevation with jaw closure using a remote-controlled airbag device, such as the airbag system, on passive upper airway collapsibility during propofol anesthesia. Seven male subjects were studied. Propofol infusion was used for anesthesia induction and maintenance, with a target blood propofol concentration of 1.5 2 g/ml. Nasal mask pressure (PN) was intermittently reduced to evaluate upper airway collapsibility (passive PCRIT ) and upstream resistance (RUS ) at three different head and jaw positions, jaw opening position in the supine position, jaw opening position in the snif ng position with 6-cm head elevation, and jaw closure at a 6-cm height snif ng position. The 6-cm height snif ng position with jaw closure was achieved by an airbag device that was attached to the subject's head-like headgear. Patient demographics, PCRIT and RUS in each condition were compared using one-way ANOVA with a post hoc Tukey test. P < 0:05 was considered signi cant. We also con rmed the effects of our airbag device on improvement of upper airway collapsibility in three obstructive sleep apnea patients in a clinical study. The combination of 6-cm head elevation with jaw closure using the air-in atable robotic airbag system decreased upper airway collapsibility (PCRIT ??3:4-cm H2O) compared with the baseline position (PCRIT ??0:8-cm H2O, P D 0:0001). In the clinical study, there was improvement of upper airway obstruction in sleep apnea patients, including decreased apnea and hypopnea duration and increased the lowest level of oxygen saturation. We demonstrated that establishment of head elevation with jaw closure achieved by a remote-controlled airbag device using an in atable airbag system can produce substantial decreases in upper airway collapsibility and maintain upper airway patency during propofol anesthesia and sleep.
Subjects/Keywords: Upper airway collapsibility; anesthesia; snif ng position; critical closing pressure
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APA ·
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APA (6th Edition):
石坂, . (2014). A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation With Jaw Closure in Normal Subjects Under Propofol Anesthesia : プロポフォール麻酔下における健常者の上気道の閉塞は、遠隔制御エアバッグ装置による頭蓋部の上昇と顎閉鎖によって改善することができる. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/35787
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
石坂, 哲. “A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation With Jaw Closure in Normal Subjects Under Propofol Anesthesia : プロポフォール麻酔下における健常者の上気道の閉塞は、遠隔制御エアバッグ装置による頭蓋部の上昇と顎閉鎖によって改善することができる.” 2014. Thesis, Nagasaki University / 長崎大学. Accessed February 28, 2021.
http://hdl.handle.net/10069/35787.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
石坂, 哲. “A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation With Jaw Closure in Normal Subjects Under Propofol Anesthesia : プロポフォール麻酔下における健常者の上気道の閉塞は、遠隔制御エアバッグ装置による頭蓋部の上昇と顎閉鎖によって改善することができる.” 2014. Web. 28 Feb 2021.
Vancouver:
石坂 . A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation With Jaw Closure in Normal Subjects Under Propofol Anesthesia : プロポフォール麻酔下における健常者の上気道の閉塞は、遠隔制御エアバッグ装置による頭蓋部の上昇と顎閉鎖によって改善することができる. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2014. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10069/35787.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
石坂 . A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation With Jaw Closure in Normal Subjects Under Propofol Anesthesia : プロポフォール麻酔下における健常者の上気道の閉塞は、遠隔制御エアバッグ装置による頭蓋部の上昇と顎閉鎖によって改善することができる. [Thesis]. Nagasaki University / 長崎大学; 2014. Available from: http://hdl.handle.net/10069/35787
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
7.
Faria, Cindy.
A Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS) e seu tratamento com cirurgia ortognática.
Degree: 2013, Universidade Fernando Pessoa
URL: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4146
► Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária
A Síndrome da Apneia/Hipopneia…
(more)
▼ Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária
A Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS) é uma síndrome com grande prevalência na sociedade actual, constituíndo um grande problema de saúde pública. A SAHOS ocorre pelo repetido estreitamento ou colapso das vias aéreas superiores (VAS) durante o sono provocando como principal síntoma uma hipersonolência diurna exessiva. Os factores de riscos mais comuns incluem o sexo masculino, a obesidade, um palato mole alongado e uma retrognatia maxilar e/ou mandibular.
A fisiopatologia da síndrome é multifactorial decorrente, em parte, de alterações das estruturas craniofaciais e dos tecidos moles das VAS associadas a alterações neuromusculares da faringe e a uma maior complacência da faringe.
Relativamente ao tratamento, existem actualmente várias modalidades, tanto comportamentais, clínicas e cirúrgicas que devem ser individualizadas e criteriosamente seleccionadas para a situação clínica de cada paciente.
Acredita-se que a SAHOS resulta na maioria das vezes de um estreitamento difuso da faringe. Para o seu tratamento é importante detectar os diferentes padrões de obstrução das VAS que parecem determinar o sucesso ou a falha do tratamento cirúrgico. As novas tecnologias permitem a criação de imagems tridimensionais a partir de imagems obtidas por ressonância magnética e tomografia computorizada juntamente com programas de reconstrução em 3 dimensões. Estas imagems tridimensionais possibilitam a avaliação dos locais de obstrução bem como proporcionam medições volumétricas das VAS.
A cirurgia de avanço maxilo-mandibular (AMM) é um movimento em cirurgia ortognática que permite o avanço bi-maxilar, aumentando o volume das VAS a nível da velo-oro-hipofaringe. Tem sido descrita como sendo o tratamento cirúrgico mais efetivo para a SAHOS (excluíndo a traqueostomia) com índices de sucesso acima dos 80%. Vários autores comprovaram a eficiência da cirurgia de AMM no aumento do espaço faríngeo, diminuindo ou mesmo eliminando os episódios de colapsos respiratórios e melhorando significativemente a qualidade do sono e de vida dos pacientes. As palavras chaves utilizadas foram: “obstructive sleep apnea syndrome”, “maxillomandibular advancement” e “upper airway obstruction” que foram associados de múltiplas formas. Obstructive Sleep Apnea/Hipopnea Syndrome (OSAH) is a highly prevalent syndrome in the society, characterized as a public health burden. OSAH occurs by recurrent episodes of upper airway (UA) obstruction or collapse during sleep with daytime somnolence as the major symptom. The principal risks factors are : male, obesity, elongated soft palate and maxillary and/or mandibular retrognathia.
Pathophysiology of OSAH is multifactorial, due partly to abnormalities of craniofacial stuctures and UA soft tissue associated with neuromuscular alterations of the pharynx and increased UA compliance.
Behavioral, clinical and…
Advisors/Committee Members: Bessa, Luís.
Subjects/Keywords: Obstructive sleep apnea syndrome; Maxillomandibular advancement; Upper airway obstruction
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APA (6th Edition):
Faria, C. (2013). A Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS) e seu tratamento com cirurgia ortognática. (Thesis). Universidade Fernando Pessoa. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4146
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Faria, Cindy. “A Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS) e seu tratamento com cirurgia ortognática.” 2013. Thesis, Universidade Fernando Pessoa. Accessed February 28, 2021.
https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4146.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Faria, Cindy. “A Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS) e seu tratamento com cirurgia ortognática.” 2013. Web. 28 Feb 2021.
Vancouver:
Faria C. A Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS) e seu tratamento com cirurgia ortognática. [Internet] [Thesis]. Universidade Fernando Pessoa; 2013. [cited 2021 Feb 28].
Available from: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4146.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Faria C. A Síndrome da Apneia/Hipopneia Obstrutiva do Sono (SAHOS) e seu tratamento com cirurgia ortognática. [Thesis]. Universidade Fernando Pessoa; 2013. Available from: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4146
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Miami University
8.
Schwietering, Laura Ann.
Speech and Breathing Characteristics in Patients with Upper
Airway Disorders: A Comparative Study.
Degree: MA, Speech Pathology and Audiology, 2013, Miami University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=miami1367278513
► This study examined the functional impact of upper airway obstruction (UAO) on speech characteristics and dyspnea. Ten participants with UAO and ten age and gender…
(more)
▼ This study examined the functional impact of
upper
airway obstruction (UAO) on speech characteristics and dyspnea. Ten
participants with UAO and ten age and gender matched healthy
participants between the ages of 10 and 35 years were recruited for
a comparative analysis. Nonparametric permutation statistics were
completed to examine the respiratory and speech variables between
groups. Analysis of respiratory data revealed participants with UAO
had significantly reduced inspiratory airflow measures, but normal
measures of inspiratory muscle strength. Analysis of speech data
revealed that participants with UAO had a significantly increased
total number of pauses, pause length, and perceptions of dyspnea
during a reading task compared to healthy participants. Analysis of
stress patterns revealed no observable trends in altered use of
intensity, fundamental frequency or duration in the UAO
participants. The impact of UAO on respiration and speech patterns
is discussed in particular for evaluation and management of this
patient population.
Advisors/Committee Members: Brehm, Susan (Advisor).
Subjects/Keywords: Speech Therapy; upper airway obstruction; subglottic stenosis; dyspnea
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APA (6th Edition):
Schwietering, L. A. (2013). Speech and Breathing Characteristics in Patients with Upper
Airway Disorders: A Comparative Study. (Masters Thesis). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1367278513
Chicago Manual of Style (16th Edition):
Schwietering, Laura Ann. “Speech and Breathing Characteristics in Patients with Upper
Airway Disorders: A Comparative Study.” 2013. Masters Thesis, Miami University. Accessed February 28, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=miami1367278513.
MLA Handbook (7th Edition):
Schwietering, Laura Ann. “Speech and Breathing Characteristics in Patients with Upper
Airway Disorders: A Comparative Study.” 2013. Web. 28 Feb 2021.
Vancouver:
Schwietering LA. Speech and Breathing Characteristics in Patients with Upper
Airway Disorders: A Comparative Study. [Internet] [Masters thesis]. Miami University; 2013. [cited 2021 Feb 28].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1367278513.
Council of Science Editors:
Schwietering LA. Speech and Breathing Characteristics in Patients with Upper
Airway Disorders: A Comparative Study. [Masters Thesis]. Miami University; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1367278513
University of Adelaide
9.
Breik, Omar.
Mandibular distraction osteogenesis in the management of airway obstruction in children with micrognathia: a systematic review.
Degree: 2015, University of Adelaide
URL: http://hdl.handle.net/2440/97968
► Background Mandibular distraction osteogenesis (MDO) is becoming increasingly commonly used as the primary surgical option for neonates and infants with upper airway obstruction secondary to…
(more)
▼ Background Mandibular distraction osteogenesis (MDO) is becoming increasingly commonly used as the primary surgical option for neonates and infants with
upper airway obstruction secondary to micrognathia or to facilitate decannulation for tracheostomy dependent children. Objectives The objective of this review was to identify and synthesize the best available evidence on the effectiveness of MDO on
airway patency, feeding, gastro-esophageal reflux (GORD) and long-term development in children born with
upper airway obstruction secondary to micrognathia. This review also aims to determine the ideal rate of distraction, and compare outcomes of external and internal distractors in this patient group. Inclusion criteria The inclusion criterion included studies in children with clinical evidence of micrognathia/Pierre Robin Sequence (PRS) who have failed conservative treatments, including both syndromic (sMicro) and non-syndromic isolated PRS (iPRS) patients. The intervention is patients who have undergone bilateral distraction osteogenesis to prevent a tracheostomy or to facilitate decannulation. The comparator intervention is patients who underwent a tracheostomy alone. The outcomes of interest include relief of
airway obstruction with MDO, decannulation of tracheostomy dependent patients, feeding and reflux changes, surgical outcomes such as comparison of rate of distraction and type of distractor. All study designs were included. Methods The databases searched included PubMed, Embase, Scopus, Web of Knowledge and grey literature sources. Of the 4815 studies found in the initial search, only 66 were included after critical appraisal. Due to the nature of the studies included, a meta-analysis was not possible. The data was pooled by calculating weighted means. Results Primary MDO for the relief of
upper airway obstruction was successful in 95% of cases in the literature. Syndromic (sMicro) patients had odds of failure that were four times higher than those of iPRS patients. The most common causes of failure are previously undiagnosed lower
airway obstruction, central apnoea, undiagnosed neurological abnormalities and complex multiorgan anomalies. Mandibular distraction osteogenesis (MDO) was less effective (80.3% success rate) at facilitating decannulation of tracheostomy dependent children. Failure in these patients was most commonly due to severe preoperative gastro-oesophageal reflux disease (GORD), swallowing dysfunction and tracheostomy related complications. The failure rate was higher when MDO was performed at an age of ≥24 months for this group of patients. Approximately 84% of children can be exclusively oral fed after MDO. The odds of needing feeding adjuncts were five times higher in syndromic children. There was a trend towards a growth decline in the first six weeks after surgery. MDO relieves GORD in the majority of patients. Patients who were tracheostomy dependent with severe GORD were at higher risk of failure to decannulate after MDO. There was no difference in success rate when comparing a…
Advisors/Committee Members: Tivey, David Robert (advisor), Umapathysivam, Kandiah (advisor), Anderson, Peter John (advisor), School of Translational Health Science (school).
Subjects/Keywords: mandibular distraction; distraction osteogenesis; micrognathia; upper airway obstruction; pierre robin; tracheostomy; craniofacial syndromes
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APA (6th Edition):
Breik, O. (2015). Mandibular distraction osteogenesis in the management of airway obstruction in children with micrognathia: a systematic review. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/97968
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Breik, Omar. “Mandibular distraction osteogenesis in the management of airway obstruction in children with micrognathia: a systematic review.” 2015. Thesis, University of Adelaide. Accessed February 28, 2021.
http://hdl.handle.net/2440/97968.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Breik, Omar. “Mandibular distraction osteogenesis in the management of airway obstruction in children with micrognathia: a systematic review.” 2015. Web. 28 Feb 2021.
Vancouver:
Breik O. Mandibular distraction osteogenesis in the management of airway obstruction in children with micrognathia: a systematic review. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/2440/97968.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Breik O. Mandibular distraction osteogenesis in the management of airway obstruction in children with micrognathia: a systematic review. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/97968
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universitat Autònoma de Barcelona
10.
Masdeu Margalef, Maria Jose.
Effect of nasal resistance on delivered continuous positive airway pressure in the treatment of sleep apnea-hypopnea syndrome.
Degree: Departament de Medicina, 2012, Universitat Autònoma de Barcelona
URL: http://hdl.handle.net/10803/96866
► Patients with obstructive sleep apnea/hypopnea syndrome (SAHS) may have difficulty exhaling against positive pressure, hence limiting their acceptance of continuous positive airway pressure (CPAP). When…
(more)
▼ Patients with obstructive sleep apnea/hypopnea syndrome (SAHS) may have difficulty exhaling against positive pressure, hence limiting their acceptance of continuous positive
airway pressure (CPAP). When patients use CPAP, the nose is the primary determinant of
upper airway resistance, and in this situation nasal resistance determines how much higher supraglottic pressure is than mask pressure. Flexible- CPAP (C-Flex) is designed to improve comfort by reducing pressure in the mask during expiration proportionally to expiratory airflow (3 settings correspond to increasing pressure changes).
We assess utility of noninvasive measures of nasal resistance during wakefulness as a predictor of directly assessed
upper airway resistance on CPAP during sleep in patients with SAHS. We hypothesized that increased nasal resistance results in increased expiratory supraglottic pressure swings that could be mitigated by the effects of C-Flex on mask pressure.
Methodology- Patients (17) with complaints of snoring and excessive daytime sleepiness were recruited. Subjects underwent daytime evaluations including clinical assessment, subjective questionnaires to assess nasal symptoms and evaluation of nasal resistance with acoustic rhinometry (AR) and active anterior rhinomanometry (RM) in the sitting and supine positions and nocturnal polysomnography on optimal CPAP with measurements of supraglottic pressure to evaluate
upper airway resistance. To create a bench test for some of our observations in patients, we designed a mechanical model of the
upper airway in patients on CPAP (ie, without a collapsible
airway). This model consisted of a rigid resistive tube, the resistance of which could be varied by changing the aperture size.
Interventions- We evaluated nasal resistance during wakefulness with AR and RM. Comparisons were made between nasal resistance using AR and RM during wakefulness, and between AR and RM awake and
upper airway resistance during sleep. In patients on fixed CPAP, CPAP with different C-Flex levels was applied multiple times during the night. In the model, 2 different respiratory patterns and resistances were tested. Airflow, expiratory mask, and supraglottic pressures were measured on CPAP and on C-Flex. Swings in pressure during expiration were determined. Comparisons were made between expiratory pressure swings on CPAP and on C-Flex.
Results- Our study shows that measures of awake nasal resistance using AR and RM had little or no correlation to each other in the sitting position, whereas there was significant but weak correlation in the supine position.
Upper airway resistance measured while on CPAP during sleep did not show significant relationships to any of the awake measures of nasal resistance (AR or RM). On CPAP, higher nasal resistance produced greater expiratory pressure swings in the supraglottis in the patients and in the model, as expected. C-Flex 3 produced expiratory drops in mask pressure (range -.03 to -2.49 cm H2O) but mitigated the expiratory pressure rise in the supraglottis only during a…
Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Rapoport, David M (director), Ayappa, Indu (director), Ferrer Monreal, Antoni (director), Broquetas Doñate, Juan María (tutor), true (authorsendemail).
Subjects/Keywords: sleep apnea; upper airway resistance; flexible-CPAP; Ciències de la Salut; 616.1
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APA ·
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CSE |
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to Zotero / EndNote / Reference
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APA (6th Edition):
Masdeu Margalef, M. J. (2012). Effect of nasal resistance on delivered continuous positive airway pressure in the treatment of sleep apnea-hypopnea syndrome. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/96866
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Masdeu Margalef, Maria Jose. “Effect of nasal resistance on delivered continuous positive airway pressure in the treatment of sleep apnea-hypopnea syndrome.” 2012. Thesis, Universitat Autònoma de Barcelona. Accessed February 28, 2021.
http://hdl.handle.net/10803/96866.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Masdeu Margalef, Maria Jose. “Effect of nasal resistance on delivered continuous positive airway pressure in the treatment of sleep apnea-hypopnea syndrome.” 2012. Web. 28 Feb 2021.
Vancouver:
Masdeu Margalef MJ. Effect of nasal resistance on delivered continuous positive airway pressure in the treatment of sleep apnea-hypopnea syndrome. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2012. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10803/96866.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Masdeu Margalef MJ. Effect of nasal resistance on delivered continuous positive airway pressure in the treatment of sleep apnea-hypopnea syndrome. [Thesis]. Universitat Autònoma de Barcelona; 2012. Available from: http://hdl.handle.net/10803/96866
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University College Cork
11.
Burns, David P.
Respiratory control in the mdx mouse model of Duchenne muscular dystrophy.
Degree: 2018, University College Cork
URL: http://hdl.handle.net/10468/6821
► Duchenne muscular dystrophy (DMD) is a genetic disease that occurs in males due to the absence of the dystrophin (427 kDa) protein. Comprehensive studies on…
(more)
▼ Duchenne muscular dystrophy (DMD) is a genetic disease that occurs in males due to the absence of the dystrophin (427 kDa) protein. Comprehensive studies on the control of breathing in DMD and animal models of the dystrophinopathies are lacking. We examined the integrated respiratory control system in a pre-clinical model of DMD – the mdx mouse. Young (8-week-old) wild-type and mdx mice were studied. During normoxia, mdx mice hypoventilated, due to decreased tidal volume with no evidence of perturbed respiratory rhythm. Carotid sinus nerve responses to hyperoxia were blunted in mdx, suggesting hypoactivity (sensory deficit). Mdx mice retained a remarkable capacity to increase ventilation during hypercapnic hypoxic breathing despite profound diaphragm muscle weakness and major structural remodelling. Peak inspiratory oesophageal pressure generation was preserved in mdx compared to wild-type mice, probably due to recruitment of accessory muscles of breathing. Monoamine concentrations were elevated in the C3-C5 spinal cord of mdx mice, and the density of activated immune cells and pro-inflammatory gene expression was unchanged, indicating no evidence of neuroinflammation. xIL-6R and Ucn2 co-treatment in mdx mice completely restored ventilation and significantly improved diaphragm and sternohyoid muscle strength. Combinational therapy restored myosin heavy chain complement in respiratory muscles. Considerable deficits arising from dystrophin lack are partly compensated, limiting ventilatory deficits in young mdx mice. Strategies aimed at preserving muscle fibre complement and quality in mdx respiratory muscles can alleviate breathing and muscle functional deficits. These data may have relevance to the development of treatments for the human dystrophinopathies.
Advisors/Committee Members: O'Halloran, Ken D..
Subjects/Keywords: Duchenne muscular dystrophy; mdx; Breathing; Diaphragm; EMG; Upper airway; Interleukin-6; Urocortin
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APA (6th Edition):
Burns, D. P. (2018). Respiratory control in the mdx mouse model of Duchenne muscular dystrophy. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/6821
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Burns, David P. “Respiratory control in the mdx mouse model of Duchenne muscular dystrophy.” 2018. Thesis, University College Cork. Accessed February 28, 2021.
http://hdl.handle.net/10468/6821.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Burns, David P. “Respiratory control in the mdx mouse model of Duchenne muscular dystrophy.” 2018. Web. 28 Feb 2021.
Vancouver:
Burns DP. Respiratory control in the mdx mouse model of Duchenne muscular dystrophy. [Internet] [Thesis]. University College Cork; 2018. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/10468/6821.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Burns DP. Respiratory control in the mdx mouse model of Duchenne muscular dystrophy. [Thesis]. University College Cork; 2018. Available from: http://hdl.handle.net/10468/6821
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
12.
Pretorius, Vincent.
Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) at Red Cross War Memorial Children’s Hospital, Cape Town: A 2-year review.
Degree: MMed, Division of Otorhinolaryngology, 2019, University of Cape Town
URL: http://hdl.handle.net/11427/30877
► Introduction: Juvenile onset recurrent respiratory papillomatosis (JoRRP) is the commonest benign paediatric neoplasm. There is no curative treatment, but the condition is self-limiting. Current primary…
(more)
▼ Introduction: Juvenile onset recurrent respiratory papillomatosis (JoRRP) is the commonest benign paediatric neoplasm. There is no curative treatment, but the condition is self-limiting. Current primary treatment is aimed at symptomatic relief, comprising of serial surgical debulking of obstructive papillomas along the respiratory tract, with voice preservation. Adjuvant therapy is indicated in severe cases. Objective: A review of children with JoRRP presenting to the ENT Department at Red Cross War Memorial Children’s Hospital (RCWMCH) over 2 years. Evaluation of the pattern of disease and factors that may contribute to disease severity were reviewed. Method: Retrospective folder review of children with histologically confirmed laryngeal papillomatosis over above the time period. Results: Twenty children were included. Nine were male, 11 were female. The median age at diagnosis was 2.4 years (11 - 109 months). Presentation at < 3 years was noted in 5/7 of the most severe cases. Nine of 20 were HPV serotyped; 5 were type 11, and 4 were type 6. Eighty percent (16/20) were HIV negative; 10% (2/20) HIV positive; and 10% (2/20) were unknown. A total of 90 surgical procedures were performed; the highest number of surgeries per child was 13. Inter-surgical time was 1 to 164 weeks (median 9 weeks). Four received Gardasil vaccination as adjuvant therapy, 3 of who showed a reduction in disease severity. Conclusion: JoRRP commonly presents around the first 3 years of life. Severe cases can be life-threatening, often with multiple hospital admissions for clearance of surgical papillomata. Severe cases presented before 3 years. Gardasil vaccination as adjuvant therapy has promise. No identifiable risk factors in our review were noted. HIV co-infection and HPV type were not risk factors for severity.
Advisors/Committee Members: Peer, Shazia (advisor), Fagan, Johan (advisor).
Subjects/Keywords: HPV; papillomatosis; JoRRP; RRP; stridor; hoarseness; Upper Airway Obstruction (UAO); Gardasil; paed
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APA ·
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MLA ·
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Export
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Manager
APA (6th Edition):
Pretorius, V. (2019). Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) at Red Cross War Memorial Children’s Hospital, Cape Town: A 2-year review. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/30877
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pretorius, Vincent. “Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) at Red Cross War Memorial Children’s Hospital, Cape Town: A 2-year review.” 2019. Thesis, University of Cape Town. Accessed February 28, 2021.
http://hdl.handle.net/11427/30877.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pretorius, Vincent. “Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) at Red Cross War Memorial Children’s Hospital, Cape Town: A 2-year review.” 2019. Web. 28 Feb 2021.
Vancouver:
Pretorius V. Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) at Red Cross War Memorial Children’s Hospital, Cape Town: A 2-year review. [Internet] [Thesis]. University of Cape Town; 2019. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11427/30877.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pretorius V. Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) at Red Cross War Memorial Children’s Hospital, Cape Town: A 2-year review. [Thesis]. University of Cape Town; 2019. Available from: http://hdl.handle.net/11427/30877
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Melbourne
13.
Cori, Jennifer Maree.
The effect of arousal induced hypocapnia on upper airway dilator muscle activity following the return to sleep.
Degree: 2016, University of Melbourne
URL: http://hdl.handle.net/11343/113709
► Obstructive sleep apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep. These episodes of collapse generally terminate with an arousal from…
(more)
▼ Obstructive sleep apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep. These episodes of collapse generally terminate with an arousal from sleep. The large ventilatory response associated with arousal is thought to predispose to further obstruction following the return to sleep by inducing hypocapnia and a subsequent reduction in upper airway dilator muscle activity. However, studies of healthy individuals and OSA patients on CPAP, have found no evidence for reduced dilator muscle activity post-arousal, rather dilator muscle activity tends to be increased. These discrepancies may be due to study limitations or alternatively, the theorised effects of arousal may be incorrect. It is possible that arousal does not induce hypocapnia, or hypocapnia is induced, but post-arousal dilator muscle activity is driven by a stimulus other than CO2. For instance, after-discharge may drive dilator muscle activity post-arousal. To assess these possibilities we conducted two studies.
Study 1 determined whether untreated OSA patients experience hypocapnia following arousals that terminate obstruction. Hypocapnia was assessed by creating an end-arousal CO2 change value (end-arousal ∆CO2) which was the PETCO2 on the last breath of arousal minus the individual’s wakefulness PETCO2. The mean end-arousal ∆CO2 was -0.6±1.8mmHg below wakefulness CO2, suggesting that the OSA patients were hypocapnic on the last breath of arousal. However, despite hypocapnia, both peak and tonic genioglossus activity were elevated above pre-arousal levels for the first two breaths following the return to sleep. In no instance did peak or tonic genioglossus activity fall below pre-arousal levels. Further, it was demonstrated that the more negative the end-arousal ∆CO2 (more reduced below wakefulness), the greater the genioglossus muscle activity was on the first five breaths following the return to sleep.
Study 2 determined whether dilator muscle after-discharge occurs following arousal and whether it is inhibited by hypocapnia. Healthy individuals were mechanically hyperventilated to (1) induce hypocapnia and (2) remove the effects of negative pressure upon dilator muscle activity. To assess normocapnia, mechanical ventilation was maintained, but additional CO2 was bled into the circuit. Study 2 demonstrated that arousal induced by auditory stimuli increased peak and tonic genioglossus activity above pre-arousal levels following the return to sleep. For the tonic component of genioglossus activity, the duration of after-discharge was no different between CO2 conditions, however for peak genioglossus activity, after-discharge was shorter following the return to sleep during hypocapnia (2 breaths) compared to normocapnia (6 breaths).
These findings suggest that arousal is not detrimental to dilator muscle activity following the return to sleep. Consistent with prior literature, dilator muscle activity was improved post-arousal for both the untreated OSA patients and the healthy participants. It is likely that this…
Subjects/Keywords: obstructive sleep apnea; arousal; sleep; hypocapnia; upper airway dilator muscles; genioglossus; apnea
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APA (6th Edition):
Cori, J. M. (2016). The effect of arousal induced hypocapnia on upper airway dilator muscle activity following the return to sleep. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/113709
Chicago Manual of Style (16th Edition):
Cori, Jennifer Maree. “The effect of arousal induced hypocapnia on upper airway dilator muscle activity following the return to sleep.” 2016. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021.
http://hdl.handle.net/11343/113709.
MLA Handbook (7th Edition):
Cori, Jennifer Maree. “The effect of arousal induced hypocapnia on upper airway dilator muscle activity following the return to sleep.” 2016. Web. 28 Feb 2021.
Vancouver:
Cori JM. The effect of arousal induced hypocapnia on upper airway dilator muscle activity following the return to sleep. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11343/113709.
Council of Science Editors:
Cori JM. The effect of arousal induced hypocapnia on upper airway dilator muscle activity following the return to sleep. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/113709
University of New South Wales
14.
Kwan, Benjamin.
Breathing movements of the human tongue and genioglossus measured with ultrasound imaging.
Degree: Clinical School - Prince of Wales Hospital, 2018, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/60357
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51914/SOURCE02?view=true
► Genioglossus muscle is the largest extrinsic tongue muscle and upper airway dilator. To maintain pharyngeal patency within and between breaths, delicate moment-to-moment coordination of pharyngeal…
(more)
▼ Genioglossus muscle is the largest extrinsic tongue muscle and
upper airway dilator. To maintain pharyngeal patency within and between breaths, delicate moment-to-moment coordination of pharyngeal muscles activity and drive is required. Dynamic pharyngeal muscle movement in response to the neural input during sleep/wake states is not clearly understood. This thesis reports a novel ultrasound method to visualise and measure dynamic genioglossus motion in healthy and OSA subjects. In Chapter 2, the method revealed ~1 mm predominantly anterior peak displacement within a 50 mm2 area in the infero-posterior genioglossus in healthy awake subjects during quiet breathing. Motion within this area was non-uniform. The method has good reliability, intraclass correlation coefficient (ICC) of 0.85 across separate imaging sessions. Chapter 3 reported good agreement between ultrasound and tagged MRI in measuring regional tongue motion in healthy and OSA subjects, with an ICC of 0.79. Compared to MRI, ultrasound revealed greater anterior displacement in the posterior tongue (mean difference of 0.24 +/- 0.64 mm, 95% limits of agreement: 1.03 to -1.49). Chapter 4 examined influence of respiratory mechanics and drive on genioglossus movement. Inspiration against a resistive load increased posterior genioglossus motion, but it had less anterior and more inferior displacement at the highest inspiratory resistance. An increase in voluntary respiratory drive resulted in increased motion and a more uniform motion within the infero-posterior genioglossus. No significant change in genioglossus motion was observed with alteration of end-expiratory lung volumes. Chapter 5 examined the patterns of posterior tongue motion in awake healthy and OSA subjects. More uniform peak inspiratory motion was recorded within the posterior genioglossus in OSA subjects. Three types of inspiratory posterior tongue motion were observed, with breath-to-breath variability within and across subjects. There may be an association between tongue motion pattern with BMI and tongue-base angle. Likely effect of the motion is to counterbalance the negative pharyngeal collapsing forces. Variation between breaths and individual is possibly due to local anatomical, neural and biomechanical factors. Future research to investigate the biomechanical behaviour of the tongue in OSA subjects during sleep with concurrent neural drive measures may further our understanding into OSA pathogenesis.
Advisors/Committee Members: Gandevia, Simon, Neuroscience Research Australia, Faculty of Medicine, UNSW, Bilston, Lynne, Neuroscience Research Australia, Faculty of Medicine, UNSW.
Subjects/Keywords: MRI; Ultrasound; Upper airway physiology; Genioglossus and tongue movement; Obstructive sleep apnoea; MRI
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APA ·
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APA (6th Edition):
Kwan, B. (2018). Breathing movements of the human tongue and genioglossus measured with ultrasound imaging. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60357 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51914/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Kwan, Benjamin. “Breathing movements of the human tongue and genioglossus measured with ultrasound imaging.” 2018. Doctoral Dissertation, University of New South Wales. Accessed February 28, 2021.
http://handle.unsw.edu.au/1959.4/60357 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51914/SOURCE02?view=true.
MLA Handbook (7th Edition):
Kwan, Benjamin. “Breathing movements of the human tongue and genioglossus measured with ultrasound imaging.” 2018. Web. 28 Feb 2021.
Vancouver:
Kwan B. Breathing movements of the human tongue and genioglossus measured with ultrasound imaging. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Feb 28].
Available from: http://handle.unsw.edu.au/1959.4/60357 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51914/SOURCE02?view=true.
Council of Science Editors:
Kwan B. Breathing movements of the human tongue and genioglossus measured with ultrasound imaging. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60357 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51914/SOURCE02?view=true
15.
Ribeiro, Annelise Nazareth Cunha.
Avaliação das vias aeríferas superiores, antes e após expansão rápida da maxila, utilizando Tomografia Computadorizada por Feixe Cônico.
Degree: Mestrado, Ortodontia, 2011, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/23/23151/tde-20092011-170219/
;
► A respiração predominantemente oral é constantemente citada como um dos fatores associados ao desenvolvimento da deficiência transversal da maxila. A Expansão Rápida da Maxila (ERM)…
(more)
▼ A respiração predominantemente oral é constantemente citada como um dos fatores associados ao desenvolvimento da deficiência transversal da maxila. A Expansão Rápida da Maxila (ERM) é um excelente método para a correção desta alteração, por meio da abertura da sutura palatina. A tomografia computadorizada por feixe cônico é tem sido descrita como um método preciso de exame de imagens e diante das limitações dos métodos radiográficos convencionais o objetivo deste estudo é avaliar as alterações morfológicas imediatas, decorrentes da ERM, na cavidade nasal e na região da naso e orofaringe, por meio da TCFC. Foram avaliadas 15 pares de imagens tomográfica, correspondentes a 15 pacientes portadores deficiência transversal da maxila, tratados com ERM, que realizaram a TCFC ao início e após o período de contenção de 4 meses. Os resultados encontrados mostram que a cavidade nasal apresenta aumento transversal significativo em seu terço inferior, nas regiões anterior (p=0,045), média (p=0,009) e posterior (p=0,001). Não há alteração significativa do volume (p=0,11), área sagital mediana (p=0,33) e menor área axial (p=0,29) decorrente da ERM na nasofaringe. Há alteração significativa do volume (p=0,05), área sagital mediana (p=0,01) e menor área axial (p=0,04) nos momentos antes e imediatamente após a ERM, na orofaringe. Após análise dos resultados concluímos que a ERM é capaz de aumentar a largura transversal da cavidade nasal, não tendo o mesmo efeito na região da nasofaringe, e que as alterações encontradas na orofaringe podem ser decorrentes de falta de padronização o posicionamento da cabeça e lingual no momento da aquisição da imagem.
The predominantly oral breathing is constantly cited as an etiological factor for the transverse maxillary deficiency. Rapid Maxillary Expansion is an excellent method for the correction of malocclusion, through the opening of the midpalatal sutures. The literature shows that the benefits of this procedure are beyond the dental benefits, and could have repercussions in the upper airways, due to its close relationship with the maxilla. The cone beam computed tomography has been described as is an accurate method of taking pictures and before the limitations of conventional radiographic methods the aim of this study is to evaluate the immediate morphological changes resulting from the ERM, the nasal cavity and the nasal region and oropharynx, through the CBCT. We evaluated 15 patients with maxillary width deficiency were treated with RME, which hosted the CBCT to the beginning and after the retention period of 3 months. The results show that the nasal cavity presents significant increase in cross their lower third, in the anterior (1.08 mm ± 0.15), medium (1.28 mm ± 0.15) and posterior (0.77 mm ± 0.12). No significant change in volume (p=0.11), median sagittal area (p=0.33) and lower axial area (p=0.29) resulting from the RME in nasopharynx. There is significant change in volume (p = 0.05), median sagittal area (p = 0.01) and lower axial area (p = 0.04) before and immediately after the…
Advisors/Committee Members: Paiva, João Batista de.
Subjects/Keywords: Cone beam computed tomography; Expansão rápida da maxila; Rapid maxillary expansion; Tomografia computadoriza por feixe cônico; Upper airway; Vias aeríferas superiors
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APA (6th Edition):
Ribeiro, A. N. C. (2011). Avaliação das vias aeríferas superiores, antes e após expansão rápida da maxila, utilizando Tomografia Computadorizada por Feixe Cônico. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23151/tde-20092011-170219/ ;
Chicago Manual of Style (16th Edition):
Ribeiro, Annelise Nazareth Cunha. “Avaliação das vias aeríferas superiores, antes e após expansão rápida da maxila, utilizando Tomografia Computadorizada por Feixe Cônico.” 2011. Masters Thesis, University of São Paulo. Accessed February 28, 2021.
http://www.teses.usp.br/teses/disponiveis/23/23151/tde-20092011-170219/ ;.
MLA Handbook (7th Edition):
Ribeiro, Annelise Nazareth Cunha. “Avaliação das vias aeríferas superiores, antes e após expansão rápida da maxila, utilizando Tomografia Computadorizada por Feixe Cônico.” 2011. Web. 28 Feb 2021.
Vancouver:
Ribeiro ANC. Avaliação das vias aeríferas superiores, antes e após expansão rápida da maxila, utilizando Tomografia Computadorizada por Feixe Cônico. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2021 Feb 28].
Available from: http://www.teses.usp.br/teses/disponiveis/23/23151/tde-20092011-170219/ ;.
Council of Science Editors:
Ribeiro ANC. Avaliação das vias aeríferas superiores, antes e após expansão rápida da maxila, utilizando Tomografia Computadorizada por Feixe Cônico. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/23/23151/tde-20092011-170219/ ;
16.
Hernandez-Zanet, Angelica Maria.
Avaliação por meio da tomografia computadorizada por feixe cônico de vias aéreas superiores de pacientes com atresia de palato, que possuem mordida cruzada posterior.
Degree: PhD, Diagnóstico Bucal, 2012, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-14012013-152546/
;
► A atresia do palato ou deficiência maxilar transversa tem comprovado a sua influência na relação craniofacial e respiratória, por isso, diversos métodos de expansão palatina…
(more)
▼ A atresia do palato ou deficiência maxilar transversa tem comprovado a sua influência na relação craniofacial e respiratória, por isso, diversos métodos de expansão palatina têm sido estudados para que haja uma melhora significativa, principalmente dos fatores respiratórios destes pacientes. O uso da tomografia por feixe cônico iniciou um novo conceito de estudo cefalométrico em terceira dimensão, no qual se consegue avaliar o paciente em todos os planos, sem que haja sobreposições de estruturas, podendo avaliar com precisão as relações craniofaciais, as vias aéreas e a relação destas estruturas. Portanto, o uso da tomografia computadorizada com ênfase na área ortodôntica, nos permite realizar um diagnóstico completo pré-tratamento ortodôntico, no qual objetivamos avaliar a correlação entre mordida cruzada posterior e a obstrução das vias aéreas superiores por meio de tomografia computadorizada por feixe cônico (TCFC). Foram utilizadas TCFC de arquivo de 32 pacientes com idade entre 6 e 14 anos, divididos em dois grupos: um grupo de 16 crianças com mordida cruzada posterior e o grupo controle . O critério de exclusão da amostra foi a realização de tratamento ortodôntico prévio, ter realizado cirurgia no complexo maxilo mandibular ou ser portador de alterações patológicas na região. Foi realizada a comparação das medidas da largura e da altura do palato em relação às medidas lineares e ao volume segmentado e total das vias aéreas superiores dos pacientes com e sem mordida cruzada posterior. No grupo com mordida cruzada, para a correlação das medidas ENP-AD2, ENP-AD1 com o volume da Baixa Naso Faringe (BNF), teve correlação moderada com a largura do palato (0,05 < p=0,089 < 0,10). Entretanto, no grupo de mordida cruzada, foi observada correlação significante entre a largura do palato e o volume total (VT). Em ambos os casos, a correlação foi positiva (r=0,786 para largura do palato com o Volume da Alta Velo Faringe (AVF) e r=0,662 para largura do palato com o VT), isto é, quanto maior a largura do palato, maior o Volume AVF e maior o VT. Estes resultados demonstram a importância do uso da TCFC, pois não foram encontradas diferenças significativas nas medidas lineares do grupo com mordida cruzada posterior e o grupo controle. Concluiu-se neste trabalho que apenas as medidas lineares não fornecem informações suficientes para a avaliação das vias aeras superiores; a profundidade do palato não possui correlação com as alterações das vias aéreas em pacientes com atresia maxilar; o grupo com mordida cruzada posterior apresentou moderada correlação da largura do palato com as medidas ENP-AD2, ENP-AD1 e o Volume da Baixa Naso Faringe; o grupo com mordida cruzada posterior apresentou correlação positiva da largura do palato com o volume da Alta Velo Faringe e com o Volume Total.
The palate atresia or transverse maxillary deficiency has proven its influence in relation craniofacial and respiratory therefore various methods of palatal expansion have been studied so there is a significant improvement, especially respiratory…
Advisors/Committee Members: Pereira, Marlene Fenyo Soeiro de Matos.
Subjects/Keywords: Cefalometria; Cephalometry; Cone-bean computed tomography; Crossbite; Measurement; Medidas; Mordida cruzada; Tomografia computadorizada por feixe cônico; Upper airway; Vias aéreas superiores
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APA ·
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APA (6th Edition):
Hernandez-Zanet, A. M. (2012). Avaliação por meio da tomografia computadorizada por feixe cônico de vias aéreas superiores de pacientes com atresia de palato, que possuem mordida cruzada posterior. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23139/tde-14012013-152546/ ;
Chicago Manual of Style (16th Edition):
Hernandez-Zanet, Angelica Maria. “Avaliação por meio da tomografia computadorizada por feixe cônico de vias aéreas superiores de pacientes com atresia de palato, que possuem mordida cruzada posterior.” 2012. Doctoral Dissertation, University of São Paulo. Accessed February 28, 2021.
http://www.teses.usp.br/teses/disponiveis/23/23139/tde-14012013-152546/ ;.
MLA Handbook (7th Edition):
Hernandez-Zanet, Angelica Maria. “Avaliação por meio da tomografia computadorizada por feixe cônico de vias aéreas superiores de pacientes com atresia de palato, que possuem mordida cruzada posterior.” 2012. Web. 28 Feb 2021.
Vancouver:
Hernandez-Zanet AM. Avaliação por meio da tomografia computadorizada por feixe cônico de vias aéreas superiores de pacientes com atresia de palato, que possuem mordida cruzada posterior. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Feb 28].
Available from: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-14012013-152546/ ;.
Council of Science Editors:
Hernandez-Zanet AM. Avaliação por meio da tomografia computadorizada por feixe cônico de vias aéreas superiores de pacientes com atresia de palato, que possuem mordida cruzada posterior. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-14012013-152546/ ;
17.
Dimitrova-Banska, Svetla / Димитрова-Банска, Светла.
Modern Methods for Surgical Treatment of Sleep Disordered Breathing /// Съвременни методи за оперативно лечение на разстройствата на дишането по време на сън.
Degree: 2014, Medical University of Varna
URL: http://repository.mu-varna.bg/handle/nls/254
► [EN] Sleep Disordered Breathing (SDB) is a clinical term including Habitual Snoring, Upper Airway Resistance Syndrome and Obstructive Sleep Apnoea Syndrome (OSAS). These problems are…
(more)
▼ [EN] Sleep Disordered Breathing (SDB) is a clinical term including Habitual Snoring, Upper Airway Resistance Syndrome and Obstructive Sleep Apnoea Syndrome (OSAS). These problems are among the social issues of our time in conjunction with their prevalence and significant negative consequences on the health of people in young and working age. Habitual snoring affects between 17.9% and 40% of men and between 7.4% and 19% of women in middle age, state the most commonly cited statistics. Distribution of OSAS is between 4-9% among men and between 2-4% among women and it is estimated that 80-90% of people with OSAS remain undiagnosed. The reported spread of OSAS in children is 5-6%. OSAS is considered as an independent risk factor for the development of systemic hypertension, cardiovascular and endocrine disorders. To date, there is no single therapeutic approach conveying final and permanent healing for all suffering from these diseases patients. Medication proved to be ineffective in the long run and use of oral devices and equipment to ensure continuous positive airway pressure, albeit with a high success rate, is undesired for the majority of patients. Surgical treatment options for patients suffering from disorders of breathing during sleep marked a significant development in the last few decades. The great advantage of good results achieved by surgery is that it is always available and the patient's life is not dependent on equipment and devices. This type of treatment is not applicable in case of centrally conditioned and mixed apnea, in patients with high degrees of obesity, severe concomitant diseases, etc. In a significant number of patients, however, where narrowing or collapses are in oropharynx, nose and epipharinx, the currently available methods of surgical treatment are used and the results are very good. According to the currently existing recommendations for treatment of disorders of breathing during sleep (AAMS, EAMS), however, as the first stage of treatment for patients with moderate and severe SOSA, CPAP is the recommended one. Surgery is eligible after unsuccessful or undesirable treatment with continuous positive airway pressure. The purpose of this thesis is: To prove that with proper selection of patients and appropriately selected techniques, surgical treatment has a place even as a first method of choice for the treatment of all forms of disorders of breathing during sleep. For a period of four years we examined and surgically treated 196 patients with disorders of breathing during sleep, aged 4 to 58. We investigated the patients by: medical history (questionnaires and scales), clinical examination, additional methods (specific manoeuvres, objective studies of breathing during sleep, imaging studies, laboratory tests). We have developed precise and clear criteria for assessing results for each type and severity of respiratory disorders. Control of the results we were able to accomplish in 165 patients (84% of the initially included in the study), and 31 patients (16%) did not show for…
Subjects/Keywords: sleep-disordered breathing; surgery; obstructive sleep apnoea; upper airway resistance syndrome (UARS); snoring; Неврохирургия / Neurosurgery; УНГ болести / ENT diseases
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APA ·
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MLA ·
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CSE |
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APA (6th Edition):
Dimitrova-Banska, Svetla / Димитрова-Банска, . (2014). Modern Methods for Surgical Treatment of Sleep Disordered Breathing /// Съвременни методи за оперативно лечение на разстройствата на дишането по време на сън. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/254
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dimitrova-Banska, Svetla / Димитрова-Банска, Светла. “Modern Methods for Surgical Treatment of Sleep Disordered Breathing /// Съвременни методи за оперативно лечение на разстройствата на дишането по време на сън.” 2014. Thesis, Medical University of Varna. Accessed February 28, 2021.
http://repository.mu-varna.bg/handle/nls/254.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dimitrova-Banska, Svetla / Димитрова-Банска, Светла. “Modern Methods for Surgical Treatment of Sleep Disordered Breathing /// Съвременни методи за оперативно лечение на разстройствата на дишането по време на сън.” 2014. Web. 28 Feb 2021.
Vancouver:
Dimitrova-Banska, Svetla / Димитрова-Банска . Modern Methods for Surgical Treatment of Sleep Disordered Breathing /// Съвременни методи за оперативно лечение на разстройствата на дишането по време на сън. [Internet] [Thesis]. Medical University of Varna; 2014. [cited 2021 Feb 28].
Available from: http://repository.mu-varna.bg/handle/nls/254.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dimitrova-Banska, Svetla / Димитрова-Банска . Modern Methods for Surgical Treatment of Sleep Disordered Breathing /// Съвременни методи за оперативно лечение на разстройствата на дишането по време на сън. [Thesis]. Medical University of Varna; 2014. Available from: http://repository.mu-varna.bg/handle/nls/254
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
18.
Nguyen, Thi Thuy Nga.
Étude tridimensionnelle de l'os hyoïde et de ses relations avec les voies aériennes supérieures (VAS) : influences des paramètres biologiques et de la typologie faciale : Three-dimensional study of the hyoid bone and of its relationships with upper airway : influences of biological parameters and facial types.
Degree: Docteur es, Anthropologie biologique, 2016, Bordeaux
URL: http://www.theses.fr/2016BORD0332
► Les variations affectant les dimensions et la forme de l’os hyoïde sont analysées chez le vivant à partir de tomodensitométries volumétriques en faisceau conique (CBCT)…
(more)
▼ Les variations affectant les dimensions et la forme de l’os hyoïde sont analysées chez le vivant à partir de tomodensitométries volumétriques en faisceau conique (CBCT) et complétées par des téléradiographies. Ces variations sont mises en relation avec différents paramètres biologiques (âge, sexe, population). La documentation regroupe 94 enfants et 83 adultes issus de 2 échantillons de populations, Française et Vietnamienne. Pour la première fois, l’existence d’une croissance différentielle de l’os hyoïde entre filles et garçons est mise en évidence, en termes d'amplitude et de chronologie des modifications osseuses. Chez l’adulte, la fusion des grandes cornes au corps de l'os hyoïde intervient dans l’évolution des dimensions de l'os mais ce processus biologique ne présente aucune loi prédictive. Aucune différence significative de l'âge de cette fusion n’est observée entre hommes et femmes et les facteurs l’influençant restent inconnus. Des variations affectant les dimensions et la forme de l'os hyoïde entre populations sont identifiées. La classification de la morphologie de l'os hyoïde selon 6 catégories qui est proposée consitue un outil pour l’étude des séries archéologiques. Des corrélations significatives entre les dimensions de l'os hyoïde et les voies aériennes supérieures sont observées, confirmant leurs relations étroites et réciproques, tant anatomique que fonctionnelle. Tous ces paramètres, évalués dans différents types faciaux, montrent en revanche des manifestations plus complexes qui nécessitent plus de recherche pour affiner les résultats.
In this study, variations of size, shape and position of the hyoid bone are analyzed with different biological parameters (age, sex, population) from Cone Beam CT and reconstitued radiographs of living people. The study sample includes 94 children and 83 adults from two populations French and Vietnamese. The results bring the first evidence of a differential growth of the hyoid bone between girls and boys in terms of magnitude and timing of bone changes. In adults, the fusion of the greater cornua with the hyoid body is involved in the dimensional changes of the bone but no significant influencing factor (like sex or population) for this biological process can be confirmed. Variations of dimension and shape of the hyoid bone between populations are identified. Within the study, a new morphological classification of the hyoid bone based on metric data is proposed. This classification distinguishes 6 categories of shape and constitutes a tool for studies of archaeological series. Significant correlations between dimensions and position of the hyoid bone and upper airways is observed, thus confirming their close mutual relationships, both anatomical and functional. All these parameters, analyzed in different facial types, show, however, a complex interaction that requires more research to refine the results.
Advisors/Committee Members: Tillier, Anne-Marie (thesis director), Boileau, Marie-José (thesis director).
Subjects/Keywords: Os hyoïde; VAS; CBCT; Typologie faciale; SAOS; Croissance; Maturation; Population; Hyoid bone; Upper airway; Facial typology; CBCT; SAOS; Growth; Maturation; Population
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APA (6th Edition):
Nguyen, T. T. N. (2016). Étude tridimensionnelle de l'os hyoïde et de ses relations avec les voies aériennes supérieures (VAS) : influences des paramètres biologiques et de la typologie faciale : Three-dimensional study of the hyoid bone and of its relationships with upper airway : influences of biological parameters and facial types. (Doctoral Dissertation). Bordeaux. Retrieved from http://www.theses.fr/2016BORD0332
Chicago Manual of Style (16th Edition):
Nguyen, Thi Thuy Nga. “Étude tridimensionnelle de l'os hyoïde et de ses relations avec les voies aériennes supérieures (VAS) : influences des paramètres biologiques et de la typologie faciale : Three-dimensional study of the hyoid bone and of its relationships with upper airway : influences of biological parameters and facial types.” 2016. Doctoral Dissertation, Bordeaux. Accessed February 28, 2021.
http://www.theses.fr/2016BORD0332.
MLA Handbook (7th Edition):
Nguyen, Thi Thuy Nga. “Étude tridimensionnelle de l'os hyoïde et de ses relations avec les voies aériennes supérieures (VAS) : influences des paramètres biologiques et de la typologie faciale : Three-dimensional study of the hyoid bone and of its relationships with upper airway : influences of biological parameters and facial types.” 2016. Web. 28 Feb 2021.
Vancouver:
Nguyen TTN. Étude tridimensionnelle de l'os hyoïde et de ses relations avec les voies aériennes supérieures (VAS) : influences des paramètres biologiques et de la typologie faciale : Three-dimensional study of the hyoid bone and of its relationships with upper airway : influences of biological parameters and facial types. [Internet] [Doctoral dissertation]. Bordeaux; 2016. [cited 2021 Feb 28].
Available from: http://www.theses.fr/2016BORD0332.
Council of Science Editors:
Nguyen TTN. Étude tridimensionnelle de l'os hyoïde et de ses relations avec les voies aériennes supérieures (VAS) : influences des paramètres biologiques et de la typologie faciale : Three-dimensional study of the hyoid bone and of its relationships with upper airway : influences of biological parameters and facial types. [Doctoral Dissertation]. Bordeaux; 2016. Available from: http://www.theses.fr/2016BORD0332
19.
Alshaer, Hisham.
A Single-Channel Acoustic Method for Portable Diagnosis of Sleep Apnea.
Degree: 2014, University of Toronto
URL: http://hdl.handle.net/1807/68884
► Background: Sleep apnea is a very common disease with serious health consequences. It affects approximately 85% of adults, most of whom remain undiagnosed, which puts…
(more)
▼ Background: Sleep apnea is a very common disease with serious health consequences. It affects approximately 85% of adults, most of whom remain undiagnosed, which puts them at risk of car accidents, because of sleepiness, and hypertension, heart failure, and stroke. The objective of this thesis was to develop a single-channel device for portable monitoring of sleep apnea that uses breath sounds collected via a microphone placed in front of the nose and mouth.
Methods:
Project 1: Frequency characterization was used to identify the basic components of the respiratory cycle, i.e., inspiration and expiration.
Project 2: Inspiratory sounds were used to determine upper airway narrowing by means of Linear Predictive Coding (LPC), which was validated against objective measures of upper airway resistance.
Project 3: An algorithm to calculate the frequency of apneas and hypopneas per hour (apnea-hypopnea index or AHI) was developed and validated against polysomnography in 50 subjects during sleep.
Project 4: Finally, a self contained device was then developed and evaluated in 49 subjects in the home setting, 11 of whom used the device on 2 different nights.
Results:
Project 1: Inspiratory and expiratory phases had characteristically different spectra that allowed them to be distinguished with up to 97% correct classification.
Project 2: LPC coefficients were found to be modulated by the ensuing of upper airway narrowing.
Project 3: AHI determined by acoustic analysis showed up to 94% correlation with PSG and up to 90% diagnostics accuracy.
Project 4: In the home unattended setting, the overall rating for ease-of-use was excellent and the success rate of independent use was 94%. The portable device showed excellent performance with very high signal-to-noise ratio of 31.7 dB. The intra-subject 2-night AHI scores were reproducible in 9 out of 11 (82%) home subjects, which is well within reported inter-night variability.
Conclusion: Acoustic analysis of breath sounds is a powerful tool for characterization of respiratory patterns including upper airway narrowing and accurate identification of apneas and hypopneas as compared with the current gold standard. This technology can be packaged in a compact device that can be used independently and reliably in the home environment.
PhD
Advisors/Committee Members: Fernie, Geoff R, Bradley, T Douglas, Biomedical Engineering.
Subjects/Keywords: Sleep Apnea; Portable Diagnosis; Acoustics; Medical Device; Signal Processing; Algorithm; Upper Airway; Breathing Phases; Usability; Embedded Module; 0541; 0986; 0564
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APA (6th Edition):
Alshaer, H. (2014). A Single-Channel Acoustic Method for Portable Diagnosis of Sleep Apnea. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/68884
Chicago Manual of Style (16th Edition):
Alshaer, Hisham. “A Single-Channel Acoustic Method for Portable Diagnosis of Sleep Apnea.” 2014. Doctoral Dissertation, University of Toronto. Accessed February 28, 2021.
http://hdl.handle.net/1807/68884.
MLA Handbook (7th Edition):
Alshaer, Hisham. “A Single-Channel Acoustic Method for Portable Diagnosis of Sleep Apnea.” 2014. Web. 28 Feb 2021.
Vancouver:
Alshaer H. A Single-Channel Acoustic Method for Portable Diagnosis of Sleep Apnea. [Internet] [Doctoral dissertation]. University of Toronto; 2014. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/1807/68884.
Council of Science Editors:
Alshaer H. A Single-Channel Acoustic Method for Portable Diagnosis of Sleep Apnea. [Doctoral Dissertation]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/68884
University of Canterbury
20.
Dey, Karla Maree.
Anatomic Dead Space Washout and Flow Effects during Breathing with Nasal High Flow Therapy.
Degree: M. Eng., Mechanical Engineering, 2014, University of Canterbury
URL: http://dx.doi.org/10.26021/2218
► Nasal high flow (NHF) therapy is a recent form of non-invasive respiratory support for patients suffering from respiratory distress that supplies high flows of heated…
(more)
▼ Nasal high flow (NHF) therapy is a recent form of non-invasive respiratory support for patients suffering from respiratory distress that supplies high flows of heated and humidified air, oxygen or a mix via a nasal cannula. A number of in vivo studies have proven its effectiveness at improving blood oxygenation; however, its mechanisms of action remain widely unproven. Two proposed mechanisms of action, the CO2 washout of anatomic dead space and the production of positive airway pressure, are investigated in this thesis for the use of the Fisher & Paykel Healthcare Ltd (FPH) Optiflow™ adult nasal cannula through a range of experiments.
Five anatomically correct upper airway models produced from computed tomography (CT) scan data via 3D printing were employed during in vitro experiments and two live subjects participated in in vivo measurements. The human respiratory system was faithfully replicated for CO2 washout experiments with physiological CO2 diffusion into the lung replicated by a constant flow of CO2 into the lung pump. In vivo measurement of a natural breathing flow pattern was scaled to an average population tidal volume and respiratory rate for in vitro use.
In vitro measurements of static pressure during natural breathing found similar flow resistances across the nasal passage for inspiratory and expiratory flow directions; however, across the entire upper airway greater resistance was seen for inspiration. Introduction of NHF therapy produced significant increases in all mean and peak airway pressures within the upper airway with a flow rate of 30 LPM fulfilling the inspiratory work requirements presented by the upper airway resistance.
In vivo and in vitro hot wire anemometry measurements at the exterior nares indicated low velocity and turbulence intensity flows at peak inspiration and a high velocity jet with high turbulence during peak expiration. At natural breathing an in vitro anterior-posterior velopharynx traverse captured low turbulence intensities during peak inspiration and high turbulence intensities during peak expiration. Introduction of NHF therapy had little influence on the turbulence intensity profile of peak expiration yet did cause significant increases in the turbulence intensities during peak inspiration.
Measurements of the CO2 concentration near the lung volume over many breath cycles were used to find time-averaged CO2 concentrations. For the standard airway model an average CO2 concentration of 4.88 ± 0.07 %V/V was determined during natural breathing. Implementation of increasing levels of NHF therapy generated significant washout of CO2 reducing this average concentration to a minimum of 3.81 ± 0.11 %V/V at a flow rate of 80 LPM. It was determined that airway geometry significantly affected the efficacy of the NHF therapy though CO2 washout was observed in all five airway models.
Subjects/Keywords: carbon dioxide washout; dead space washout; nasal high flow; cannula; respiration; upper airway; breathing therapy; in vitro model
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APA (6th Edition):
Dey, K. M. (2014). Anatomic Dead Space Washout and Flow Effects during Breathing with Nasal High Flow Therapy. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/2218
Chicago Manual of Style (16th Edition):
Dey, Karla Maree. “Anatomic Dead Space Washout and Flow Effects during Breathing with Nasal High Flow Therapy.” 2014. Masters Thesis, University of Canterbury. Accessed February 28, 2021.
http://dx.doi.org/10.26021/2218.
MLA Handbook (7th Edition):
Dey, Karla Maree. “Anatomic Dead Space Washout and Flow Effects during Breathing with Nasal High Flow Therapy.” 2014. Web. 28 Feb 2021.
Vancouver:
Dey KM. Anatomic Dead Space Washout and Flow Effects during Breathing with Nasal High Flow Therapy. [Internet] [Masters thesis]. University of Canterbury; 2014. [cited 2021 Feb 28].
Available from: http://dx.doi.org/10.26021/2218.
Council of Science Editors:
Dey KM. Anatomic Dead Space Washout and Flow Effects during Breathing with Nasal High Flow Therapy. [Masters Thesis]. University of Canterbury; 2014. Available from: http://dx.doi.org/10.26021/2218
University of New South Wales
21.
Ng, Andrew Tze Ming.
Effect of mandibular advancement splint therapy on upper airway structure and function in obstructive sleep apnoea.
Degree: Clinical School - St George Hospital, 2009, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/44845
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:8142/SOURCE02?view=true
► Obstructive sleep apnoea (OSA) is a common disorder characterized by repetitive closure of the upper airway during sleep and associated with significant adverse health effects…
(more)
▼ Obstructive sleep apnoea (OSA) is a common disorder characterized by repetitive closure of the upper airway during sleep and associated with significant adverse health effects including hypertension, heart disease and stroke. Current treatment with continuous positive airway pressure (CPAP) is highly effective but reduced compliance levels have resulted in suboptimal outcomes. Oral appliances such as mandibular advancement splints (MAS) are an alternative treatment and have potential advantages including greater patient compliance, comfort and portability. Although they have been shown to be successful across all categories of OSA severity, overall they are less effective than CPAP. A key limitation to its more widespread use has been the inability to predict which patients will be a treatment success. Prediction of treatment outcome would greatly enhance both MAS utilization and overall OSA management. However, little is known about the mechanisms of action of MAS therapy and a more detailed understanding is likely to improve patient selection and outcome. The aim of this thesis is to improve the prediction of treatment outcome through improved understanding of the mechanisms and site(s) of action of MAS therapy during sleep, through extrapolating this knowledge into daytime prediction tests and by developing prediction equations which can be tested prospectively. The work in this thesis presents novel ideas and findings. It is the first to examine and find that MAS therapy improves upper airway collapsibility during sleep. The site(s) of upper airway collapse was also examined and found to predict treatment outcome. Primary oropharyngeal collapse during sleep predicted treatment success and this was extrapolated into a simple daytime test hypothesized to reflect oropharyngeal function. These primary oropharyngeal collapsers were found to have characteristic awake flow-volume curves and this was then studied prospectively. Cephalometric X-rays and anthropomorphic measurements were also evaluated to formulate prediction equations for treatment outcome with MAS. These new findings together with their implications for clinical practice and future research are then summarized. It is concluded, however, that although many advancements have been made, the mechanisms of MAS action and prediction of treatment outcome remain incompletely understood reflecting the complex pathophysiology of the upper airway.
Subjects/Keywords: Upper airway physiology; Obstructive sleep apnoea; Mandibular advancement splint
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APA (6th Edition):
Ng, A. T. M. (2009). Effect of mandibular advancement splint therapy on upper airway structure and function in obstructive sleep apnoea. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/44845 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:8142/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Ng, Andrew Tze Ming. “Effect of mandibular advancement splint therapy on upper airway structure and function in obstructive sleep apnoea.” 2009. Doctoral Dissertation, University of New South Wales. Accessed February 28, 2021.
http://handle.unsw.edu.au/1959.4/44845 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:8142/SOURCE02?view=true.
MLA Handbook (7th Edition):
Ng, Andrew Tze Ming. “Effect of mandibular advancement splint therapy on upper airway structure and function in obstructive sleep apnoea.” 2009. Web. 28 Feb 2021.
Vancouver:
Ng ATM. Effect of mandibular advancement splint therapy on upper airway structure and function in obstructive sleep apnoea. [Internet] [Doctoral dissertation]. University of New South Wales; 2009. [cited 2021 Feb 28].
Available from: http://handle.unsw.edu.au/1959.4/44845 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:8142/SOURCE02?view=true.
Council of Science Editors:
Ng ATM. Effect of mandibular advancement splint therapy on upper airway structure and function in obstructive sleep apnoea. [Doctoral Dissertation]. University of New South Wales; 2009. Available from: http://handle.unsw.edu.au/1959.4/44845 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:8142/SOURCE02?view=true
University of Toronto
22.
Schwarz, Peter Bogdan.
Dopaminergic Control of Trigeminal Motor Outflow to Upper Airway Muscles in Anaesthetized Rats.
Degree: 2009, University of Toronto
URL: http://hdl.handle.net/1807/17710
► The role of dopamine in directly modulating somatic motoneuron excitability and hence muscle tone is unknown. We investigated whether dopamine influences the trigeminal motor pool…
(more)
▼ The role of dopamine in directly modulating somatic motoneuron excitability and hence muscle tone is unknown. We investigated whether dopamine influences the trigeminal motor pool (MoV) that innervates the masseter and tensor palatini muscles, both of which function to maintain upper airway patency. We hypothesized that dopamine facilitates motor outflow at the MoV. We focally applied apomorphine (nonspecific dopamine receptor agonist) at the MoV in anaesthetized rats. We also applied receptor-specific agonists and antagonists to determine the receptor subtype mediating dopaminergic mechanisms of action. We demonstrated that dopaminergic transmission at the MoV potently increased motor outflow via the D1-like receptor and facilitated masseter and tensor palatini muscle tone. It is unknown whether endogenous dopamine release on to airway motoneurons influences their activity to regulate muscle tone in natural sleep-wake behaviours. This issue warrants investigation because the neurochemical basis of upper airway motor dysfunction (e.g. obstructive sleep apnea) remains poorly characterized.
MAST
Advisors/Committee Members: Peever, John H., Cell and Systems Biology.
Subjects/Keywords: dopamine; trigeminal motor nucleus; tensor palatini; obstructive sleep apnea; upper airway patency; 0317
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APA (6th Edition):
Schwarz, P. B. (2009). Dopaminergic Control of Trigeminal Motor Outflow to Upper Airway Muscles in Anaesthetized Rats. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/17710
Chicago Manual of Style (16th Edition):
Schwarz, Peter Bogdan. “Dopaminergic Control of Trigeminal Motor Outflow to Upper Airway Muscles in Anaesthetized Rats.” 2009. Masters Thesis, University of Toronto. Accessed February 28, 2021.
http://hdl.handle.net/1807/17710.
MLA Handbook (7th Edition):
Schwarz, Peter Bogdan. “Dopaminergic Control of Trigeminal Motor Outflow to Upper Airway Muscles in Anaesthetized Rats.” 2009. Web. 28 Feb 2021.
Vancouver:
Schwarz PB. Dopaminergic Control of Trigeminal Motor Outflow to Upper Airway Muscles in Anaesthetized Rats. [Internet] [Masters thesis]. University of Toronto; 2009. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/1807/17710.
Council of Science Editors:
Schwarz PB. Dopaminergic Control of Trigeminal Motor Outflow to Upper Airway Muscles in Anaesthetized Rats. [Masters Thesis]. University of Toronto; 2009. Available from: http://hdl.handle.net/1807/17710
Université Paris-Sud – Paris XI
23.
Hagot, Pascal.
Evaluation de l’interaction fluide-structure dans les Voies Aériennes Supérieures par Imagerie par Résonance Magnétique : Evaluation of the upper airway fluid/structure coupling using magnetic resonance imaging during a breath cycle.
Degree: Docteur es, Physique, 2015, Université Paris-Sud – Paris XI
URL: http://www.theses.fr/2015PA112059
► Le Syndrome d’Apnée Obstructive du Sommeil affecte 4 à 6 % de la population en France soit près de 3 millions de personnes. Toutefois, les…
(more)
▼ Le Syndrome d’Apnée Obstructive du Sommeil affecte 4 à 6 % de la population en France soit près de 3 millions de personnes. Toutefois, les techniques de diagnostic usuelles ne permettent pas de déterminer de façon précise les sites d’occlusion ni de décrire les interactions fluide-paroi qui jouent un rôle important dans les processus de fermeture des voies aériennes supérieures. Au cours de ce travail, un ensemble d’outil a été mis en œuvre pour explorer les mécanismes sous-jacents conduisant à une apnée obstructive. La détermination géométrique et la caractérisation mécanique des voies aériennes supérieures, d’une part, la mesure des écoulements dans ces dernières, d’autre part, ont été réalisées par imagerie par résonance magnétique de l’hydrogène, pour les tissus, de l’hélium-3 et du fluor-19 pour les gaz. Les données obtenues ont été exploitées tout d’abord dans un modèle numérique statique pour estimer les lois d’état locales et caractériser la compliance des voies aériennes supérieures, puis, dans un modèle monodimensionnel, prenant en compte l’interaction fluide-structure et la limitation de débit au cours de l’inspiration, pour localiser les sites potentiellement responsables d’un éventuel collapsus. Par ailleurs, les écoulements de gaz d’hélium-3 et d’hexafluorure de soufre ont été simulés afin de déterminer le potentiel de ces deux modalités d’imagerie de gaz pour l’étude des obstructions des voies aériennes. La faisabilité d’une imagerie statique et dynamique par résonance magnétique du fluor a été démontrée. Avec une densité du gaz traceur bien plus importante, cette dernière technique présente une plus grande sensibilité à l’obstruction. Cette thèse ouvre ainsi une nouvelle voie de diagnostic et de guide thérapeutique personnalisé pour ce syndrome.
Obstructive Sleep Apnea (OSA) is a common disorder occurring in almost 3 million French people. However, current diagnosis methods are not sufficient to precisely define obstructing sites and doesn't take into account the fluid structure coupling which plays an important role during upper airway closing. During this thesis, we developed a series of tools exploring upper airway closing process. On the one hand, a screening tool of the structure and the mechanical properties of the upper airway, and on the other hand, a screening tool exploring with dynamic images of inert gases flow into the upper airway, were obtained using conventional hydrogen MRI coupled to magnetic resonance elastography (MRE) and helium-3 or fluor-19 gases MRI, respectively. Geometric and biomechanical data obtained using MRI/MRE are injected into a numerical model given the compliance and the state law of upper airway. Contributions of anatomical restriction on airway collapse are also investigated using a multi-compartmental two-dimensional fluid structure interaction model during a breath inspiration to predicted airway mechanical changes and collapse pressures. Furthermore, helium 3 and sulfur hexafluoride flow was modeled at steady state using commercial finite volume software to…
Advisors/Committee Members: Darrasse, Luc (thesis director).
Subjects/Keywords: IRM; Apnée du sommeil obstructive; Hélium-3 hyperpolarisé; Fluor-19; Élastographie; VAS; SAOS; IRM dynamique; MRI; Obstructive sleep apnea; Hyperpolarized helium-3; Fluor-19; Elastography; Upper airway; Dynamic MRI
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APA (6th Edition):
Hagot, P. (2015). Evaluation de l’interaction fluide-structure dans les Voies Aériennes Supérieures par Imagerie par Résonance Magnétique : Evaluation of the upper airway fluid/structure coupling using magnetic resonance imaging during a breath cycle. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2015PA112059
Chicago Manual of Style (16th Edition):
Hagot, Pascal. “Evaluation de l’interaction fluide-structure dans les Voies Aériennes Supérieures par Imagerie par Résonance Magnétique : Evaluation of the upper airway fluid/structure coupling using magnetic resonance imaging during a breath cycle.” 2015. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed February 28, 2021.
http://www.theses.fr/2015PA112059.
MLA Handbook (7th Edition):
Hagot, Pascal. “Evaluation de l’interaction fluide-structure dans les Voies Aériennes Supérieures par Imagerie par Résonance Magnétique : Evaluation of the upper airway fluid/structure coupling using magnetic resonance imaging during a breath cycle.” 2015. Web. 28 Feb 2021.
Vancouver:
Hagot P. Evaluation de l’interaction fluide-structure dans les Voies Aériennes Supérieures par Imagerie par Résonance Magnétique : Evaluation of the upper airway fluid/structure coupling using magnetic resonance imaging during a breath cycle. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2015. [cited 2021 Feb 28].
Available from: http://www.theses.fr/2015PA112059.
Council of Science Editors:
Hagot P. Evaluation de l’interaction fluide-structure dans les Voies Aériennes Supérieures par Imagerie par Résonance Magnétique : Evaluation of the upper airway fluid/structure coupling using magnetic resonance imaging during a breath cycle. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2015. Available from: http://www.theses.fr/2015PA112059
Freie Universität Berlin
24.
Matin, Farnaz.
The value of sleep endoscopy and nasal airflow obstruction in the differential therapy of obstructive snoring and obstructive sleep apnea syndrome.
Degree: 2019, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-2575
► Objective This study aimed to analyse the importance of drug induced sleep endoscopy in an individually tailored operational therapy concept for patients with obstructive snoring…
(more)
▼ Objective
This study aimed to analyse the importance of drug induced sleep endoscopy in an individually tailored operational therapy concept for patients with obstructive snoring and selected patients with obstructive sleep apnea syndrome (OSAS).
Methods
This retrospective study included 76 patients with obstructive snoring and OSAS who underwent sleep endoscopy using propofol for sedation for individual treatment recommendations. At the ENT-center Berlin-Lichterfelde Ost a two-step approach was generally preferred. As a first step, a sleep endoscopy to localize obstruction in the
upper airway was combined with nasal surgery to optimize nasal breathing. After a healing period of ten to twelve weeks and request for further treatment a second procedure was performed in which tissue previously identified in the sleep endoscopy was tightened or reduced. The success of treatment was evaluated by follow-up examinations as well as patient questionnaires.
Results
A total of 76 patients (20 female and 56 male patients between 26 and 79 years old) underwent propofol induced sleep endoscopy. Of these, 72 patients with corresponding nasal symptoms underwent a surgical procedure to improve nasal airflow, and three patients were operated on the point of obstruction in the oropharynx. 46 patients (60,5% of 76 patients) were diagnosed with unilevel obstruction while multilevel obstruction was identified in 30 patients (39,5% of 76 patients). At the follow-up examinations a correlation between the amelioration of the nasal obstruction and the improvement of snoring symptoms was already recognizable. 28 patients (51,9% of 54 patients) indicated an improvement of their snoring and nine patients (29,0% of 31 patients) reported less severe breathing interruptions. On the basis of the sleep endoscopy findings, 31 patients were recommended to undergo surgical treatment and eight patients were advised to use a mandibular advancement device. Ten patients decided to undergo a second surgery in the pharyngeal region (uvula flap and subcapsular laser tonsillectomy) and, if applicable, at the tongue base (celon therapy). Review of patient questionnaires indicated a statistically significant improvement of snoring, nasal airflow obstruction, nocturnal breathing interruptions and sleep satisfaction.
Conclusion
Knowledge of the source of snoring sounds and
upper airway obstruction is decisive for patients with obstructive snoring and with limitation for patients with OSAS to determine purposeful and successful surgical treatment. This precise localization is enabled by drug induced sleep endoscopy.
Advisors/Committee Members: female (gender), N.N. (inspector), N.N. (firstReferee).
Subjects/Keywords: upper airway resistance syndrome; obstructive sleep apnea syndrome; drug induced sleep endoscopy; nasal airflow obstruction; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
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APA (6th Edition):
Matin, F. (2019). The value of sleep endoscopy and nasal airflow obstruction in the differential therapy of obstructive snoring and obstructive sleep apnea syndrome. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-2575
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Matin, Farnaz. “The value of sleep endoscopy and nasal airflow obstruction in the differential therapy of obstructive snoring and obstructive sleep apnea syndrome.” 2019. Thesis, Freie Universität Berlin. Accessed February 28, 2021.
http://dx.doi.org/10.17169/refubium-2575.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Matin, Farnaz. “The value of sleep endoscopy and nasal airflow obstruction in the differential therapy of obstructive snoring and obstructive sleep apnea syndrome.” 2019. Web. 28 Feb 2021.
Vancouver:
Matin F. The value of sleep endoscopy and nasal airflow obstruction in the differential therapy of obstructive snoring and obstructive sleep apnea syndrome. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2021 Feb 28].
Available from: http://dx.doi.org/10.17169/refubium-2575.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Matin F. The value of sleep endoscopy and nasal airflow obstruction in the differential therapy of obstructive snoring and obstructive sleep apnea syndrome. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-2575
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
New Jersey Institute of Technology
25.
Erdogan, Ferhat.
Submandibular mechanical stimulation of upper airway muscles to treat obstructive sleep apnea.
Degree: PhD, Biomedical Engineering, 2018, New Jersey Institute of Technology
URL: https://digitalcommons.njit.edu/dissertations/1412
► The extrinsic tongue muscles are activated in coordination with pharyngeal muscles to keep a patent airway during respiration in wakefulness and sleep. The activity…
(more)
▼ The extrinsic tongue muscles are activated in coordination with pharyngeal muscles to keep a patent
airway during respiration in wakefulness and sleep. The activity of genioglossus, the primary tongue-protruding muscle playing an important role in this coordination, is known to be modulated by several reflex pathways mediated through the mechanoreceptors of the
upper airways. The main objective is to investigate the effectiveness of activating these reflex pathways with mechanical stimulations, for the long-term goal of improving the
upper airway patency during disordered breathing in sleep. The genioglossus response is examined during mandibular and sub-mandibular mechanical stimulations in healthy subjects during wakefulness. The genioglossus activity is recorded with custom-made sublingual EMG electrode molded out of silicone. Mechanical vibrations are applied to the lower jaw at 8 and 12 Hz with an amplitude of 5 mm in the first experiment, and to the sub-mandibular area at three different intensities (0.2-0.9 mm, 21-33 Hz) in the second experiment. The effects of sub-mandibular mechanical vibrations are also investigated in severe obstructive sleep apnea patients during a whole night sleep study. The major findings of this study are that the genioglossus reflexively responds to the mechanical vibrations applied to the mandible and the sub-mandibular skin surface in healthy subjects during wakefulness and the sub-mandibular stimulations during sleep terminate the apnea earlier and decrease the level of hypoxia with smaller micro arousals.
Advisors/Committee Members: Mesut Sahin, Sergei Adamovich, Judy Deutsch.
Subjects/Keywords: Genioglossus; Jaw tongue reflex; Obstructive sleep apnea; Stimulation; Tonic vibration reflex; Upper airway; Bioimaging and Biomedical Optics; Biomedical Engineering and Bioengineering; Neurosciences
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APA (6th Edition):
Erdogan, F. (2018). Submandibular mechanical stimulation of upper airway muscles to treat obstructive sleep apnea. (Doctoral Dissertation). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/dissertations/1412
Chicago Manual of Style (16th Edition):
Erdogan, Ferhat. “Submandibular mechanical stimulation of upper airway muscles to treat obstructive sleep apnea.” 2018. Doctoral Dissertation, New Jersey Institute of Technology. Accessed February 28, 2021.
https://digitalcommons.njit.edu/dissertations/1412.
MLA Handbook (7th Edition):
Erdogan, Ferhat. “Submandibular mechanical stimulation of upper airway muscles to treat obstructive sleep apnea.” 2018. Web. 28 Feb 2021.
Vancouver:
Erdogan F. Submandibular mechanical stimulation of upper airway muscles to treat obstructive sleep apnea. [Internet] [Doctoral dissertation]. New Jersey Institute of Technology; 2018. [cited 2021 Feb 28].
Available from: https://digitalcommons.njit.edu/dissertations/1412.
Council of Science Editors:
Erdogan F. Submandibular mechanical stimulation of upper airway muscles to treat obstructive sleep apnea. [Doctoral Dissertation]. New Jersey Institute of Technology; 2018. Available from: https://digitalcommons.njit.edu/dissertations/1412
26.
Launois, Claire.
Propriétés neurophysiologiques des voies aériennes supérieures à l'éveil chez le sujet sain et le patient ayant un syndrome d'apnées obstructives du sommeil : influence du décubitus dorsal : Neurophysiological properties of the upper airway during wakefulness in healthy subject and in patient with obstructive sleep apnea syndrome : influence of the supine position.
Degree: Docteur es, Physiologie, physiopathologie et thérapeutique, 2018, Sorbonne université
URL: http://www.theses.fr/2018SORUS582
► Le syndrome d’apnées obstructives du sommeil (SAOS) se caractérise par un collapsus répété des voies aériennes supérieures (VAS) durant le sommeil. Il résulte d’anomalies anatomiques…
(more)
▼ Le syndrome d’apnées obstructives du sommeil (SAOS) se caractérise par un collapsus répété des voies aériennes supérieures (VAS) durant le sommeil. Il résulte d’anomalies anatomiques des VAS qui constituent une charge inspiratoire et d’un défaut de réponse neuromusculaire à cette charge durant le sommeil. A l’éveil, il n’y a jamais de collapsus des VAS ce qui suggère l’existence de mécanismes compensatoires. Cette thèse explore ces mécanismes en étudiant la réponse à la charge imposée par le décubitus dorsal chez des sujets sains et des patients SAOS à l’éveil. Nous retrouvons chez 42% des patients SAOS éveillés en position assise une activité corticale liée à la ventilation (potentiels pré-inspiratoires, PPI) qui est absente chez les sujets sains (étude 1) et qui pourrait traduire une augmentation de la commande ventilatoire en réponse aux anomalies des VAS. Le passage en décubitus dorsal s’accompagne de l’apparition d’un PPI chez 46% des sujets sains vraisemblablement en lien avec une augmentation de la charge liée au déplacement de liquides des membres inférieurs vers la région cervicale (étude 2). A l’inverse, chez les patients SAOS, le décubitus dorsal est associé à une diminution significative de l’incidence des PPI mais à une augmentation de l’activité du génioglosse, muscle dilatateur des VAS (étude 3), probablement réflexe à une augmentation de la pression négative pharyngée générée par la charge imposée par le décubitus. Ces données montrent une réponse corticale différente des sujets sains et des patients SAOS face à la charge induite par le décubitus dorsal, ce qui contribue à mieux comprendre le contrôle des VAS et la physiopathologie du SAOS.
The obstructive sleep apnea syndrome (OSAS) is characterized by recurrent upper airway (UA) collapse during sleep. It involves UA anatomical abnormalities accompanied by increased inspiratory load and defect in compensatory neuromuscular response to this load during sleep. UA collapse does not occur during wakefulness, suggesting that wakefulness-dependant neuromuscular response compensates for the increased inspiratory load. This thesis investigates these compensatory mechanisms by studying the response to the load imposed by the supine position in healthy subjects and OSAS patients during wakefulness. We found in 42% of awake OSAS patients studied in sitting position, a respiratory-related cortical activity (pre-inspiratory potentials, PIP). This activity was absent in healthy subjects (study 1) and could correspond to an increased neural drive in response to UA abnormalities. Moving to supine position was associated with the occurrence of PIP in 46% of healthy subjects probably related to an increase in fluid shift from the legs to the neck (study 2). Conversely, in OSAS patients, supine position was associated with a significant decrease in the incidence of PIP but with an increase in the genioglossus activity, an UA dilator muscle, (study 3), probably reflex to the increase in pharyngeal negative pressure induced by the load imposed by supine position.…
Advisors/Committee Members: Similowski, Thomas (thesis director), Redolfi, Stefania (thesis director).
Subjects/Keywords: Syndrome d'apnées obstructives du sommeil; Charge inspiratoire; Décubitus dorsal; Contrôle des voies aériennes supérieures; Potentiels pré-inspiratoires; Génioglosse; Obstructive sleep apnea syndrome; Upper airway control; Supine position; 616.209
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APA (6th Edition):
Launois, C. (2018). Propriétés neurophysiologiques des voies aériennes supérieures à l'éveil chez le sujet sain et le patient ayant un syndrome d'apnées obstructives du sommeil : influence du décubitus dorsal : Neurophysiological properties of the upper airway during wakefulness in healthy subject and in patient with obstructive sleep apnea syndrome : influence of the supine position. (Doctoral Dissertation). Sorbonne université. Retrieved from http://www.theses.fr/2018SORUS582
Chicago Manual of Style (16th Edition):
Launois, Claire. “Propriétés neurophysiologiques des voies aériennes supérieures à l'éveil chez le sujet sain et le patient ayant un syndrome d'apnées obstructives du sommeil : influence du décubitus dorsal : Neurophysiological properties of the upper airway during wakefulness in healthy subject and in patient with obstructive sleep apnea syndrome : influence of the supine position.” 2018. Doctoral Dissertation, Sorbonne université. Accessed February 28, 2021.
http://www.theses.fr/2018SORUS582.
MLA Handbook (7th Edition):
Launois, Claire. “Propriétés neurophysiologiques des voies aériennes supérieures à l'éveil chez le sujet sain et le patient ayant un syndrome d'apnées obstructives du sommeil : influence du décubitus dorsal : Neurophysiological properties of the upper airway during wakefulness in healthy subject and in patient with obstructive sleep apnea syndrome : influence of the supine position.” 2018. Web. 28 Feb 2021.
Vancouver:
Launois C. Propriétés neurophysiologiques des voies aériennes supérieures à l'éveil chez le sujet sain et le patient ayant un syndrome d'apnées obstructives du sommeil : influence du décubitus dorsal : Neurophysiological properties of the upper airway during wakefulness in healthy subject and in patient with obstructive sleep apnea syndrome : influence of the supine position. [Internet] [Doctoral dissertation]. Sorbonne université; 2018. [cited 2021 Feb 28].
Available from: http://www.theses.fr/2018SORUS582.
Council of Science Editors:
Launois C. Propriétés neurophysiologiques des voies aériennes supérieures à l'éveil chez le sujet sain et le patient ayant un syndrome d'apnées obstructives du sommeil : influence du décubitus dorsal : Neurophysiological properties of the upper airway during wakefulness in healthy subject and in patient with obstructive sleep apnea syndrome : influence of the supine position. [Doctoral Dissertation]. Sorbonne université; 2018. Available from: http://www.theses.fr/2018SORUS582
Curtin University of Technology
27.
Tetlow, George A.
Modelling human upper-airway dynamics and dysfunction
.
Degree: 2012, Curtin University of Technology
URL: http://hdl.handle.net/20.500.11937/1867
► Repetitive closure of the upper-airway characterises obstructive sleep apnea. It disrupts sleep causing excessive daytime drowsiness, and is linked to hypertension and cardiovascular disease.Previous studies…
(more)
▼ Repetitive closure of the upper-airway characterises obstructive sleep apnea. It disrupts sleep causing excessive daytime drowsiness, and is linked to hypertension and cardiovascular disease.Previous studies simulating the underlying fluid mechanics of two-dimensional channel flow are based upon velocity-driven boundaries with symmetric positioning of the soft-palate. In the first part of the present work the two-dimensional work of Balint (2001) is extended to a pressure-driven model where the stability solutions space mapped for the soft-palate, symmetrically placed within viscous channel flow. As a result of this work the modelling of Obstructive Sleep Apnoea (OSA) it is proposed that modelling should focus on nasal breathing as the first indicator for the presence of OSA. Numerical simulations reveal the appearance of amplification of soft-palate displacement over several breathing cycles with asymmetric positioning of the soft-plate and for nasal breathing (single channel flow). Such events increase airway hydraulic resistance at the start of inhalation, a vulnerably period of the breathing cycle for collapse of the pharynx.In the second part of the present work three-dimensional studies are conducted for duct flow and flow through an anatomically correct reconstructed geometry, supporting the findings of the two-dimensional work of the first part. Moreover, extending understanding of anatomical interactions, through development of a three-dimensional geometry reconstruction based on an airway at the end of inhalation. Here the geometry is reconstructed from quantitative date linked to the breathing cycle, captured via an in vivo method using an adapted endoscope technique. Simulations reveal flow mechanisms that produce low-pressure regions on the side walls of the pharynx and on the soft-palate within the pharyngeal section of minimum area. Soft-palate displacement and lateral pharynx-wall deformations reduce further the pressures in these regions creating forces that would tend to narrow the airway owing to flow curvature. These phenomena suggest a mechanism for airway closure in the lateral direction as observed in an bronchoscope study conducted as part of this thesis.
Subjects/Keywords: turbulent model k − ω SST;
human upper-airway;
obstructive sleep apnoea;
3-D pharynx model;
numerical modelling;
2- D soft-palate model;
viscous flow;
biomechanical;
pressure driven;
stability solution space
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APA ·
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Manager
APA (6th Edition):
Tetlow, G. A. (2012). Modelling human upper-airway dynamics and dysfunction
. (Thesis). Curtin University of Technology. Retrieved from http://hdl.handle.net/20.500.11937/1867
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tetlow, George A. “Modelling human upper-airway dynamics and dysfunction
.” 2012. Thesis, Curtin University of Technology. Accessed February 28, 2021.
http://hdl.handle.net/20.500.11937/1867.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tetlow, George A. “Modelling human upper-airway dynamics and dysfunction
.” 2012. Web. 28 Feb 2021.
Vancouver:
Tetlow GA. Modelling human upper-airway dynamics and dysfunction
. [Internet] [Thesis]. Curtin University of Technology; 2012. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/20.500.11937/1867.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tetlow GA. Modelling human upper-airway dynamics and dysfunction
. [Thesis]. Curtin University of Technology; 2012. Available from: http://hdl.handle.net/20.500.11937/1867
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université de Sherbrooke
28.
Jia, Wan Lu.
Effets d’une résistance inspiratoire sur les reflux gastro-œsophagiens chez l’agneau nouveau-né: Effects of an inspiratory resistance on gastroesophageal refluxes in the newborn lamb.
Degree: 2019, Université de Sherbrooke
URL: http://hdl.handle.net/11143/15124
► Abstract: Introduction: Gastroesophageal refluxes (GER) are common in the healthy human newborn. In certain conditions, however, increased GER can cause deleterious complications, such as esophagitis…
(more)
▼ Abstract: Introduction: Gastroesophageal refluxes (GER) are common in the healthy human
newborn. In certain conditions, however, increased GER can cause deleterious
complications, such as esophagitis and apnea-bradycardias. Studying the conditions that
can raise the number of GER is essential to prevent those complications. In clinical settings,
it is a commonly accepted that
upper airway obstruction (UAO) increases GER. However,
there is no direct evidence to our knowledge of this association. The objective of this study
is to create a newborn ovine model of UAO and test the hypothesis that mimicking UAO
increases the number of GER in newborn lambs.
Material and methods: Eight newborn lambs were included in the study. They were
chronically instrumented with an esophageal impedance-pHmetry catheter as well as
subcutaneous sensors for 6-hour polysomnography recordings. Each lamb was studied in
two conditions, control and resistance, on two consecutive days in a randomised order. A
nasal mask applied permanently an inspiratory resistance mimicking a moderate to severe
UAO. Other physiological signals measured were for recording states of alertness,
electrocardiogram (EKG), tracheal pressure, respiratory movements, oximetry, arterial
blood gases and data relative to GER.
Results: The target tracheal pressure, demonstrating increased inspiratory efforts in
response to a moderate to severe UAO, could be maintained in all lambs throughout the
six-hour recording [-14 (-15, -13) cmH2O vs. -1 (-2, -1) cmH2O in control condition, p <
0,001]. The number of GER was statistically significantly elevated in the resistance
compared to the control condition [1(0, 4) vs 3(2, 6), p = 0.05]; this was however not
observed in all lambs. Some lambs also had a statistically elevated number of proximal
GER in the resistance condition [0 (0, 1) vs. 0 (0, 0)].
Conclusion: We have successfully created a unique and reproducible newborn ovine model
of moderate to severe UAO. While globally significant, the increased number of GERs
during 6 hours in this model is less than anticipated and even absent in some lambs. Further
studies should be done in order to understand the underlying mechanisms.
Advisors/Committee Members: Praud, Jean-Paul (advisor).
Subjects/Keywords: Obstruction des voies respiratoires supérieures; Reflux gastro-oesophagiens; Résistance inspiratoire; Impédance-pHmétrie; Agneau; Nourrisson; Upper airway obstruction; Gastroesophageal reflux; Inspiratory resistance; Impedance-pHmetry; Lamb; Newborn
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APA ·
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APA (6th Edition):
Jia, W. L. (2019). Effets d’une résistance inspiratoire sur les reflux gastro-œsophagiens chez l’agneau nouveau-né: Effects of an inspiratory resistance on gastroesophageal refluxes in the newborn lamb. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/15124
Chicago Manual of Style (16th Edition):
Jia, Wan Lu. “Effets d’une résistance inspiratoire sur les reflux gastro-œsophagiens chez l’agneau nouveau-né: Effects of an inspiratory resistance on gastroesophageal refluxes in the newborn lamb.” 2019. Masters Thesis, Université de Sherbrooke. Accessed February 28, 2021.
http://hdl.handle.net/11143/15124.
MLA Handbook (7th Edition):
Jia, Wan Lu. “Effets d’une résistance inspiratoire sur les reflux gastro-œsophagiens chez l’agneau nouveau-né: Effects of an inspiratory resistance on gastroesophageal refluxes in the newborn lamb.” 2019. Web. 28 Feb 2021.
Vancouver:
Jia WL. Effets d’une résistance inspiratoire sur les reflux gastro-œsophagiens chez l’agneau nouveau-né: Effects of an inspiratory resistance on gastroesophageal refluxes in the newborn lamb. [Internet] [Masters thesis]. Université de Sherbrooke; 2019. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/11143/15124.
Council of Science Editors:
Jia WL. Effets d’une résistance inspiratoire sur les reflux gastro-œsophagiens chez l’agneau nouveau-né: Effects of an inspiratory resistance on gastroesophageal refluxes in the newborn lamb. [Masters Thesis]. Université de Sherbrooke; 2019. Available from: http://hdl.handle.net/11143/15124
Queens University
29.
Le Huquet, Ariel.
Jaw Movement During Sleep
.
Degree: Physiology, 2008, Queens University
URL: http://hdl.handle.net/1974/1403
► Objective: We aim to improve our understanding of sleep physiology by describing the changes in mandibular position during sleep in normal subjects. Methods: We developed…
(more)
▼ Objective: We aim to improve our understanding of sleep physiology by describing the
changes in mandibular position during sleep in normal subjects. Methods: We developed
a novel method for mapping mandibular position simultaneously in three dimensions
(anteroposterior, vertical and lateral) using magneto-resistive sensors strategically placed
around 3 different moving joints on an external apparatus attached to the head and
mandible. Spherical coordinates derived from these sensors provided information of jaw
position in each of the three measurement planes. We assessed changes in jaw position in
twelve healthy subjects (6 male, 6 female) aged (mean ± SD) 23 ± 7 years, Body Mass
Index 22.5 ± 3.4 kg/m2, and with nasal resistance 3.24 ± 0.67 cmH2O/L/s by recording
mandibular position simultaneously with overnight sleep polysomnography. Results: Jaw
position was significantly influenced by sleep stage (p<0.001). The transition from wake
to light sleep (stage one) was accompanied by significant jaw closure and jaw protrusion
(p<0.05). As non-rapid-eye-movement (NREM) sleep deepened from stages 1 through
slow wave sleep (SWS), vertical jaw opening (p<0.05) and posterior jaw movement
progressively increased (p<0.05). REM sleep was associated with the greatest degree of
jaw opening of all sleep stages (p<0.05). Lateral jaw position was not significantly
different between sleep stages. Conclusion: This study describes, for the first time, an
accurate method of measuring changes in mandibular position during sleep in all three
dimensions. The observed changes during sleep in healthy subjects suggest a
simultaneous modulation of upper airway muscular tone, which may be important in the
understanding of upper airway occlusion in Obstructive Sleep Apnea.
Subjects/Keywords: Mandibular movement
;
Jaw Movement
;
Obstructive Sleep Apnea
;
Sleep
;
Upper Airway
;
Physiology
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APA ·
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Manager
APA (6th Edition):
Le Huquet, A. (2008). Jaw Movement During Sleep
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1403
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Le Huquet, Ariel. “Jaw Movement During Sleep
.” 2008. Thesis, Queens University. Accessed February 28, 2021.
http://hdl.handle.net/1974/1403.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Le Huquet, Ariel. “Jaw Movement During Sleep
.” 2008. Web. 28 Feb 2021.
Vancouver:
Le Huquet A. Jaw Movement During Sleep
. [Internet] [Thesis]. Queens University; 2008. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/1974/1403.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Le Huquet A. Jaw Movement During Sleep
. [Thesis]. Queens University; 2008. Available from: http://hdl.handle.net/1974/1403
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Kyoto University
30.
Fujimura, Shintaro.
Discrimination of “Hot Potato Voice” Caused by Upper Airway Obstruction Utilizing a Support Vector Machine
.
Degree: 2020, Kyoto University
URL: http://hdl.handle.net/2433/252976
Subjects/Keywords: Hot potato voice;
Upper airway obstruction;
Articulatory speech synthesis;
Support vector machine
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APA ·
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Manager
APA (6th Edition):
Fujimura, S. (2020). Discrimination of “Hot Potato Voice” Caused by Upper Airway Obstruction Utilizing a Support Vector Machine
. (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/252976
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fujimura, Shintaro. “Discrimination of “Hot Potato Voice” Caused by Upper Airway Obstruction Utilizing a Support Vector Machine
.” 2020. Thesis, Kyoto University. Accessed February 28, 2021.
http://hdl.handle.net/2433/252976.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fujimura, Shintaro. “Discrimination of “Hot Potato Voice” Caused by Upper Airway Obstruction Utilizing a Support Vector Machine
.” 2020. Web. 28 Feb 2021.
Vancouver:
Fujimura S. Discrimination of “Hot Potato Voice” Caused by Upper Airway Obstruction Utilizing a Support Vector Machine
. [Internet] [Thesis]. Kyoto University; 2020. [cited 2021 Feb 28].
Available from: http://hdl.handle.net/2433/252976.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fujimura S. Discrimination of “Hot Potato Voice” Caused by Upper Airway Obstruction Utilizing a Support Vector Machine
. [Thesis]. Kyoto University; 2020. Available from: http://hdl.handle.net/2433/252976
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
◁ [1] [2] ▶
. 
Open Access Theses and Dissertations
