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Erasmus University Rotterdam
1.
Y. Luan (Ying).
Ultrasound-triggered drug release from vibrating microbubbles.
Degree: 2014, Erasmus University Rotterdam
URL: http://hdl.handle.net/1765/77649 
► markdownabstract__Abstract__ Diagnostic medical ultrasound may have a slightly longer history than what you expected. Its root dates back to 1930s and 1940s, when Theodore Dussik,…
(more)
▼ markdownabstract__Abstract__
Diagnostic medical ultrasound may have a slightly longer history than what you expected. Its root dates back to 1930s and 1940s, when Theodore Dussik, a psychiatrist and neurologist, and his brother Friederich used a 1.5 MHz source to record signal variations after transmitting the wave through the human brain. Although these images were later shown to measure the skull bone attenuation instead of brain ventricles as the Dussik brothers had believed, it was one of the earliest attempts to scan an in vivo organ (White 1988). The real developments of medical ultrasound imaging initiated after Second World War, since 1950s, when the “pulse echo” technique was adapted from military sonar and radar. For the practicality to position the setup for medical imaging, only a single transducer was used to measure the reflected wave from the target sample in contrast to transmission, which measures the wave transmitted through the medium by a sending transducer and a separate receiving transducer. In early 1950s, John Wild and John Reid developed the first hand-held imaging device which was applied to image breast cancer tumors (Newman and Rozycki 1998). However, it was not until 1960s and 1970s, with the development of electronics, these pioneering works truly came to fruition. The static B-mode imaging was replaced by real-time imaging modalities thanks to new techniques such as phased linear arrays (Seibert 1995). One of the major breakthroughs (which is also of special meaning to the author) is the multi-element linear arrays developed by the group headed by Professor Nicolaas Bom at Thoraxcenter, Erasmus medical center Rotterdam. The probe face consists of 20 crystals which can produce 20 scan lines in total. Figure 1.1 shows the design of the probe and the real-time cardiac image it produced. This early simple concept has later evolved into the more complicate real-time scanners that are widely available today. The later combination of real-time imaging with pulsed wave Doppler technique enabled accurate measurements of the blood flow, which greatly benefited diagnostic echocardiography.
Subjects/Keywords: ultrasound; echocardiography
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APA (6th Edition):
(Ying), Y. L. (2014). Ultrasound-triggered drug release from vibrating microbubbles. (Thesis). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/77649
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
(Ying), Y. Luan. “Ultrasound-triggered drug release from vibrating microbubbles.” 2014. Thesis, Erasmus University Rotterdam. Accessed January 21, 2021.
http://hdl.handle.net/1765/77649.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
(Ying), Y. Luan. “Ultrasound-triggered drug release from vibrating microbubbles.” 2014. Web. 21 Jan 2021.
Vancouver:
(Ying) YL. Ultrasound-triggered drug release from vibrating microbubbles. [Internet] [Thesis]. Erasmus University Rotterdam; 2014. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1765/77649.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
(Ying) YL. Ultrasound-triggered drug release from vibrating microbubbles. [Thesis]. Erasmus University Rotterdam; 2014. Available from: http://hdl.handle.net/1765/77649
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Addis Ababa University
2.
Hailemariam, Berhane.
An Audit of Completion of Ultrasound Request form at BLH
.
Degree: 2014, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/5963
► Objective: To audit the adequacy of completion of ultrasound request formsreferred to the radiology department from the different wards /OPD of the hospital Design:Cross-sectional study…
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▼ Objective: To audit the adequacy of completion of
ultrasound request formsreferred to the radiology department from the different wards /OPD of the hospital Design:Cross-sectional study Place and duration of study:Diagnostic Radiology Department of Addis Ababa University of medical faculty, from October 15, 2014 to October 30, 2012. Methods:A total of 218
ultrasound request form in study period were analyzed for completion using a blind ended questioner. The data were cleaned and entered in to SPSS-20 software package. Frequency and percentage were used for this categorical variable. Result:A total of 218
ultrasound requests forms were reviewed. All of them had the names of the patients filled, 218 (100%) and almost all had their father name filled except 5(2.3%). Only 168 (77.7%) of them had their ages filled, and 164 of 218 (75.2%) had their sex filled (Table-1).One hundred and eighty nine (86.7%) had hospital number while, 29(13.3%) did not haveinformation regarding hospital number.Detailed clinical data were filled in 184 (84.4%), and not mentioned at all in 34(15.6%) of them. Although 83.3% (181/218) of them had mentioned the requesting physician name, only 8 (3.7%) and 6 (2.8%) filled the relevant laboratory information and previous data respectively
Conclusion: We conclude that radiological investigation forms are still incompletely and inadequately filled. This will have effect on the quality and the overall service provided by the radiologist and may have effect sometimes on clinical decisions and outcomes. There is need to encourage the managing clinician to complete and adequately fill all the required information into the request form and appreciate its importance to patient’s management. This can be achieved by increasing the awareness of referring clinicians through repeated continue medical
education in conjunction with the radiologists and the need for a regular clinical-radiological meetings.
Advisors/Committee Members: Tesfaye Kebede (MD) Associate professor of radiology, AAU-MF (advisor).
Subjects/Keywords: audit; ultrasound
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APA (6th Edition):
Hailemariam, B. (2014). An Audit of Completion of Ultrasound Request form at BLH
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5963
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hailemariam, Berhane. “An Audit of Completion of Ultrasound Request form at BLH
.” 2014. Thesis, Addis Ababa University. Accessed January 21, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/5963.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hailemariam, Berhane. “An Audit of Completion of Ultrasound Request form at BLH
.” 2014. Web. 21 Jan 2021.
Vancouver:
Hailemariam B. An Audit of Completion of Ultrasound Request form at BLH
. [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Jan 21].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/5963.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hailemariam B. An Audit of Completion of Ultrasound Request form at BLH
. [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5963
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Urbana-Champaign
3.
Johnson, Chenara A.
Examining the biophysics of ultrasound and contrast agent induced angiogenesis.
Degree: PhD, 0408, 2012, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/29461
► Ischemic diseases affect more than 100 million people in the United States alone (NDFS 2011, Roger et al. 2011). Current interventions include: ablation, angioplasty, revascularization…
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▼ Ischemic diseases affect more than 100 million people in the United States alone (NDFS 2011, Roger et al. 2011). Current interventions include: ablation, angioplasty, revascularization and bypass surgery. The invasive nature of these techniques excludes patients with who are not amenable to surgical intervention. For this reason, alternative methods of revascularization in ischemic cardiac muscle have been explored. Over the past two decades, cellular, molecular, and genetic therapy attempts have been made in order to find a clinically relevant treatment. Ultimately, it is the invasiveness or lack of site specificity that provides the largest obstacle for therapeutic effectiveness of angiogenic treatments.
Current research suggests that
ultrasound-ultrasound contrast agent treatment can be therapeutically beneficial, providing a noninvasive way to spatially and temporally target ischemic tissues. This type of angiogenic therapy can be used as an alternative to high risk percutaneous intervention or bypass graft surgery. Several studies report a reparative response to
ultrasound-ultrasound contrast agent exposure and state that inertial cavitation, or microbubble collapse, is possibly required for angiogenesis to occur. Numerous small-scale studies have shown promising results; however, when large scale double blind studies were conducted, they showed limited effects. A major impediment for progress to clinical applicability is, perhaps, the lack of understanding the biophysical mechanisms that connect
ultrasound-ultrasound contrast agent to neovascularization.
This thesis seeks to explore the biophysics of
ultrasound-ultrasound contrast agent-induced capillary angiogenesis, specifically examining the role of the
ultrasound contrast agent in creating bioeffects that lead to subsequent angiogenesis. The mechanistic exploration examines both the necessity and concentration of
ultrasound contrast agents, bubble dynamics, the biophysical effects of
ultrasound contrast agents and several
ultrasound parameters on causing/enhancing
ultrasound-induced angiogenesis.
A series of experiments were conducted to examine the biophysics of
ultrasound and
ultrasound contrast agent induced angiogenesis. The first experiment explores the effect of
ultrasound contrast agents on
ultrasound-induced angiogenesis with a 3 x 2 x 4 factorial study assessing survival day, infusion media (saline or
ultrasound contrast agent) and acoustic pressure, respectively. Then, several exposure-effect studies are presented to examine the specific parameters on the bioeffect and subsequent angiogenic response, both acutely (at 0 day) and at 5 days post exposure.
Ultrasound contrast agent concentration is initially explored, followed by a revisit of pressures involvement at a higher contrast agent concentration. In an effort to further understand the biophysical mechanism, a collapse threshold study was conducted, narrowing the pressure range to determine if/ the extent to which collapse was necessary for angiogenesis. Then theoretical…
Advisors/Committee Members: O'Brien, William D. (advisor), O'Brien, William D. (Committee Chair), Insana, Michael F. (committee member), Oelze, Michael L. (committee member), Bunick, David (committee member).
Subjects/Keywords: angiogenesis; ultrasound; ultrasound contrast agents; therapeutic ultrasound; ultrasound induced angiogenesis
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APA (6th Edition):
Johnson, C. A. (2012). Examining the biophysics of ultrasound and contrast agent induced angiogenesis. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/29461
Chicago Manual of Style (16th Edition):
Johnson, Chenara A. “Examining the biophysics of ultrasound and contrast agent induced angiogenesis.” 2012. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 21, 2021.
http://hdl.handle.net/2142/29461.
MLA Handbook (7th Edition):
Johnson, Chenara A. “Examining the biophysics of ultrasound and contrast agent induced angiogenesis.” 2012. Web. 21 Jan 2021.
Vancouver:
Johnson CA. Examining the biophysics of ultrasound and contrast agent induced angiogenesis. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2012. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/2142/29461.
Council of Science Editors:
Johnson CA. Examining the biophysics of ultrasound and contrast agent induced angiogenesis. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2012. Available from: http://hdl.handle.net/2142/29461
University of Melbourne
4.
Collis, James Robert.
Acoustic microstreaming in the vicinity of oscillating microbubbles.
Degree: 2012, University of Melbourne
URL: http://hdl.handle.net/11343/38475
► Acoustic microstreaming has gained increased interest in the past few years due to innovative medical treatments such as sonoporation and sonothrombolysis [1-4]; however, few flow…
(more)
▼ Acoustic microstreaming has gained increased interest in the past few years due to innovative medical treatments such as sonoporation and sonothrombolysis [1-4]; however, few flow visualizations or measurements of velocity fields and other significant metrics havebeen conducted. In this study, work first conducted by Tho et al. [2] has been further explored. Micro-PIV (Particle Image Velocimetry) measurements and streak photography were used to study the flow field around single bubbles, ranging in diameters of 30-300 um, oscillating in various fluid mediums. The bubbles were attached onto the lower surface of a microchamber (pendant), and held in place via capillary forces. Previous studies have focused on the visible secondary flow of acoustic microstreaming, not the potentially more significant primary flow within the Stokes boundary layer. Since primary-flow velocities are much higher, they may exert stresses on nearby surfaces and be of much greater biological significance. In this study, whilst the key focus has still been at studying the secondary flow fields, a novel approach was used to capture and quantify the velocity/speed of the primary vortices, which were observed to be twice an order of magnitude stronger than the secondary vortices. Surfactants have been introduced into the fluid medium to study the possible effects on microstreaming and if there was a correlation to observed increases in rates of rectified diffusion. The addition of surfactants lead to an increase in the streaming metrics, however the results did not fully correlate with those of observed increased rates of rectified diffusion. This would suggest that the increase in streaming velocity due to the introduction of surfactants is not the primary driver for the increase in rectified diffusion rates.
Subjects/Keywords: microfluidics; ultrasound
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APA (6th Edition):
Collis, J. R. (2012). Acoustic microstreaming in the vicinity of oscillating microbubbles. (Masters Thesis). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38475
Chicago Manual of Style (16th Edition):
Collis, James Robert. “Acoustic microstreaming in the vicinity of oscillating microbubbles.” 2012. Masters Thesis, University of Melbourne. Accessed January 21, 2021.
http://hdl.handle.net/11343/38475.
MLA Handbook (7th Edition):
Collis, James Robert. “Acoustic microstreaming in the vicinity of oscillating microbubbles.” 2012. Web. 21 Jan 2021.
Vancouver:
Collis JR. Acoustic microstreaming in the vicinity of oscillating microbubbles. [Internet] [Masters thesis]. University of Melbourne; 2012. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/11343/38475.
Council of Science Editors:
Collis JR. Acoustic microstreaming in the vicinity of oscillating microbubbles. [Masters Thesis]. University of Melbourne; 2012. Available from: http://hdl.handle.net/11343/38475
University of Toronto
5.
Vukovich, Michael.
Decimation and Analysis: An Internal Bleeding Detection Framework for 3D Ultrasound.
Degree: 2018, University of Toronto
URL: http://hdl.handle.net/1807/89561
► This thesis proposes a decimation-analysis (D-A) framework for detecting internal bleeding in 3D ultrasound medical scans. The structure consists of two main components: decimation, in…
(more)
▼ This thesis proposes a decimation-analysis (D-A) framework for detecting internal bleeding in 3D ultrasound medical scans. The structure consists of two main components: decimation, in which an input volume is reduced to suspect regions, and analysis, in which feature extraction is performed on said suspect regions. The D-A framework was designed to identify intuitive, easily-identiable features of blood pools as an aid for obtaining more complex shape information that can be assessed and matched to "library" data created from training volumes. The D-A framework is presented here for its concept and structure rather than for its actual performance, as rigorous, accurate testing was beyond the scope of the thesis; however, access to accurately segmented ground truth volumes (something missing during the experiment) would enable more in-depth development and validation of the framework.
M.A.S.
Advisors/Committee Members: Plataniotis, Kostas N., Electrical and Computer Engineering.
Subjects/Keywords: 3D ultrasound; hemoperitoneum; segmentation; trauma; ultrasound; 0544
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APA (6th Edition):
Vukovich, M. (2018). Decimation and Analysis: An Internal Bleeding Detection Framework for 3D Ultrasound. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/89561
Chicago Manual of Style (16th Edition):
Vukovich, Michael. “Decimation and Analysis: An Internal Bleeding Detection Framework for 3D Ultrasound.” 2018. Masters Thesis, University of Toronto. Accessed January 21, 2021.
http://hdl.handle.net/1807/89561.
MLA Handbook (7th Edition):
Vukovich, Michael. “Decimation and Analysis: An Internal Bleeding Detection Framework for 3D Ultrasound.” 2018. Web. 21 Jan 2021.
Vancouver:
Vukovich M. Decimation and Analysis: An Internal Bleeding Detection Framework for 3D Ultrasound. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1807/89561.
Council of Science Editors:
Vukovich M. Decimation and Analysis: An Internal Bleeding Detection Framework for 3D Ultrasound. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89561
Delft University of Technology
6.
Generowicz, Bas (author).
Improving Ultrafast Doppler Imaging using Subspace Tracking.
Degree: 2019, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:51cfae12-461d-4910-bd8f-a0dff5237af8
► High frame rate Doppler ultrasound imaging provides a new way to image blood motion at thousands of frames per second. It has gained popularity due…
(more)
▼ High frame rate Doppler ultrasound imaging provides a new way to image blood motion at thousands of frames per second. It has gained popularity due to its high spatio-temporal resolution, which is re- quired to distinguish blood motion from clutter signals caused by slow moving tissue. Since the flow of blood inside the brain is coupled to neural activity it is now possible to study brain function with the use of Ultrafast Doppler. This technique is called functional UltraSound (fUS), and forms a new and exciting research area. fUS relies heavily on optimized signal processing techniques to acquire and process a large amount of high frame-rate images in real-time. This thesis is about establishing the software backbone to allow for fUS experiments. Furthermore, it describes the development and implementation of a computationally efficient method of obtaining vascular images, based on the Projection Approximation Subspace Tracking (PAST) method. The PAST algorithm is able to display accurate representations of the blood subspace, while maintaining a lower computational complexity than the state-of-the-art method, making it suitable for Doppler imaging. When applied to fUS, the ex- ponentially weighted PASTd method achieves a similar performance in highlighting the functional areas of the brain as compared to the current state-of-the-art method, over multiple functional experiments, however with the benefit of lower computational complexity. These findings highlight the potential of applying PAST methods to Ultra- fast Doppler imaging.
Electrical Engineering | Signals and Systems
Advisors/Committee Members: Leus, Geert (mentor), Delft University of Technology (degree granting institution).
Subjects/Keywords: Doppler; Ultrasound; functional ultrasound; SVD; Subspace Tracking
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APA (6th Edition):
Generowicz, B. (. (2019). Improving Ultrafast Doppler Imaging using Subspace Tracking. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:51cfae12-461d-4910-bd8f-a0dff5237af8
Chicago Manual of Style (16th Edition):
Generowicz, Bas (author). “Improving Ultrafast Doppler Imaging using Subspace Tracking.” 2019. Masters Thesis, Delft University of Technology. Accessed January 21, 2021.
http://resolver.tudelft.nl/uuid:51cfae12-461d-4910-bd8f-a0dff5237af8.
MLA Handbook (7th Edition):
Generowicz, Bas (author). “Improving Ultrafast Doppler Imaging using Subspace Tracking.” 2019. Web. 21 Jan 2021.
Vancouver:
Generowicz B(. Improving Ultrafast Doppler Imaging using Subspace Tracking. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Jan 21].
Available from: http://resolver.tudelft.nl/uuid:51cfae12-461d-4910-bd8f-a0dff5237af8.
Council of Science Editors:
Generowicz B(. Improving Ultrafast Doppler Imaging using Subspace Tracking. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:51cfae12-461d-4910-bd8f-a0dff5237af8
University of Minnesota
7.
Sheaff, Clay.
All-optical ultrasound transducers for high resolution imaging.
Degree: PhD, Biomedical Engineering, 2014, University of Minnesota
URL: http://hdl.handle.net/11299/171722
► High frequency ultrasound (HFUS) has increasingly been used within the past few decades to provide high resolution (< 200 µm) imaging in medical applications such…
(more)
▼ High frequency ultrasound (HFUS) has increasingly been used within the past few decades to provide high resolution (< 200 µm) imaging in medical applications such as endoluminal imaging, intravascular imaging, ophthalmology, and dermatology. The optical detection and generation of HFUS using thin films offers numerous advantages over traditional piezoelectric technology. Circumvention of an electronic interface with the device head is one of the most significant given the RF noise, crosstalk, and reduced capacitance that encumbers small-scale electronic transducers. Thin film Fabry-Perot interferometers - also known as etalons - are well suited for HFUS receivers on account of their high sensitivity, wide bandwidth, and ease of fabrication. In addition, thin films can be used to generate HFUS when irradiated with optical pulses - a method referred to as Thermoelastic Ultrasound Generation (TUG). By integrating a polyimide (PI) film for TUG into an etalon receiver, we have created for the first time an all-optical ultrasound transducer that is both thermally stable and capable of forming fully sampled 2-D imaging arrays of arbitrary configuration. Here we report (1) the design and fabrication of PI-etalon transducers; (2) an evaluation of their optical and acoustic performance parameters; (3) the ability to conduct high-resolution imaging with synthetic 2-D arrays of PI-etalon elements; and (4) work towards a fiber optic PI-etalon for in vivo use. Successful development of a fiber optic imager would provide a unique field-of-view thereby exposing an abundance of prospects for minimally-invasive analysis, diagnosis, and treatment of disease.
Subjects/Keywords: Optics; Photoacoustic; Ultrasound; Photoacoustic; Ultrasound; Biomedical engineering
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APA (6th Edition):
Sheaff, C. (2014). All-optical ultrasound transducers for high resolution imaging. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/171722
Chicago Manual of Style (16th Edition):
Sheaff, Clay. “All-optical ultrasound transducers for high resolution imaging.” 2014. Doctoral Dissertation, University of Minnesota. Accessed January 21, 2021.
http://hdl.handle.net/11299/171722.
MLA Handbook (7th Edition):
Sheaff, Clay. “All-optical ultrasound transducers for high resolution imaging.” 2014. Web. 21 Jan 2021.
Vancouver:
Sheaff C. All-optical ultrasound transducers for high resolution imaging. [Internet] [Doctoral dissertation]. University of Minnesota; 2014. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/11299/171722.
Council of Science Editors:
Sheaff C. All-optical ultrasound transducers for high resolution imaging. [Doctoral Dissertation]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/171722
University of Alberta
8.
Ge, Chang.
Studies of Ultrasound Distribution and Ultrasound Generation
Efficiency of Transducers.
Degree: MS, Department of Electrical and Computer
Engineering, 2014, University of Alberta
URL: https://era.library.ualberta.ca/files/mp48sg303
► Renewable energy production is an important application of ultrasound waves. Ultrasound waves can increase the ethanol and biodiesel generated by biomass during metabolic behaviour. Ultrasound…
(more)
▼ Renewable energy production is an important
application of ultrasound waves. Ultrasound waves can increase the
ethanol and biodiesel generated by biomass during metabolic
behaviour. Ultrasound distribution and ultrasound generation
efficiency of transducers are important for these applications. The
ultrasound distribution and ultrasound generation efficiency of
transducers were studied in this project. Theories of ultrasound
distribution and ultrasound transducer were studied during
literature survey. A method of transducer modeling was proposed
based on research works before for studies of ultrasound
distribution of a cylindrical transducer, which will be used in
biodiesel production system in the future. Validation of the model
was carried out. The model of a cylindrical transducer was built.
The ultrasound distribution described by the model was validated by
both simulation in MATLAB and measurement by a hydrophone. Studies
of ultrasound generation efficiency were carried out from a
mechanics point of view. Governing equations for displacement
distribution over the transducer active surface were studied. A
physical quantity was proposed for comparison of generation
efficiency between different transducer structures. Transducer
arrays with rectangular plate transducers being the element were
validated by MATLAB simulation to be more efficient in ultrasound
generation than a cylindrical transducer. A triangular prism
transducer array was proposed to replace a cylindrical transducer
in applications.
Subjects/Keywords: Transducer; Ultrasound distribution
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APA ·
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Manager
APA (6th Edition):
Ge, C. (2014). Studies of Ultrasound Distribution and Ultrasound Generation
Efficiency of Transducers. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/mp48sg303
Chicago Manual of Style (16th Edition):
Ge, Chang. “Studies of Ultrasound Distribution and Ultrasound Generation
Efficiency of Transducers.” 2014. Masters Thesis, University of Alberta. Accessed January 21, 2021.
https://era.library.ualberta.ca/files/mp48sg303.
MLA Handbook (7th Edition):
Ge, Chang. “Studies of Ultrasound Distribution and Ultrasound Generation
Efficiency of Transducers.” 2014. Web. 21 Jan 2021.
Vancouver:
Ge C. Studies of Ultrasound Distribution and Ultrasound Generation
Efficiency of Transducers. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2021 Jan 21].
Available from: https://era.library.ualberta.ca/files/mp48sg303.
Council of Science Editors:
Ge C. Studies of Ultrasound Distribution and Ultrasound Generation
Efficiency of Transducers. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/mp48sg303
University of Waterloo
9.
Owais, Tirad.
Capacitive Micromachined Ultrasound Transducers for Non-Destructive Testing Applications.
Degree: 2020, University of Waterloo
URL: http://hdl.handle.net/10012/15920
► The need for using ultrasound non-destructive testing (NDT) to characterize, test and detect flaws within metals, led us to utilize Capacitive Micromachined Ultrasound Transducers (CMUTs)…
(more)
▼ The need for using ultrasound non-destructive testing (NDT) to characterize, test and detect flaws within metals, led us to utilize Capacitive Micromachined Ultrasound Transducers (CMUTs) in the ultrasound NDT field. This is due to CMUT's large bandwidths and high receive sensitivity, to be a suitable substitute for piezoelectric (PZT) transducers in NDT applications.
The basic operational test of CMUTs, conducted in this research, was carried out based on a pulse-echo technique by propagating acoustic pulses into an object and analyzing the reflected signals. Thus, characterizing the tested material, measuring its dimension, and detecting flaws within it can be achieved.
Throughout the course of this research, the fundamental parameters of CMUT including pull-in voltage and resonance frequency were initially calculated analytically and using Finite Element Analysis (FEA). Afterward, the CMUT was fabricated out of two mechanically bonded wafers. The device's movable membrane (top electrode) and stationary electrode (bottom electrode) were made out of Boron-doped Silicon. The two electrodes were electrically isolated by an insulation layer containing a sealed gap.
The CMUT was then tested and characterized to analyze its performance for NDT applications. In-immersion characterization revealed that the 2.22 MHz CMUT obtained a -6 dB fractional bandwidth of 189%, and a receive sensitivity of 31.15 mV/kPa, compared to 45% and 4.83 mV/kPa of the PZT probe. A pulse-echo test, performed to examine an aluminum block with and without flaws, showed success in distinguishing the surfaces and the flaws of the tested sample.
Subjects/Keywords: CMUT; NDT ultrasound
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APA (6th Edition):
Owais, T. (2020). Capacitive Micromachined Ultrasound Transducers for Non-Destructive Testing Applications. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/15920
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Owais, Tirad. “Capacitive Micromachined Ultrasound Transducers for Non-Destructive Testing Applications.” 2020. Thesis, University of Waterloo. Accessed January 21, 2021.
http://hdl.handle.net/10012/15920.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Owais, Tirad. “Capacitive Micromachined Ultrasound Transducers for Non-Destructive Testing Applications.” 2020. Web. 21 Jan 2021.
Vancouver:
Owais T. Capacitive Micromachined Ultrasound Transducers for Non-Destructive Testing Applications. [Internet] [Thesis]. University of Waterloo; 2020. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/10012/15920.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Owais T. Capacitive Micromachined Ultrasound Transducers for Non-Destructive Testing Applications. [Thesis]. University of Waterloo; 2020. Available from: http://hdl.handle.net/10012/15920
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Waterloo
10.
Burnett, Lauren.
Wave Refraction Effects in High Intensity Focused Ultrasound.
Degree: 2019, University of Waterloo
URL: http://hdl.handle.net/10012/14376
► High-Intensity Focused Ultrasound (HIFU) is a promising field of research being developed as an alternative to surgery and radiation therapy for the treatment of tumours.…
(more)
▼ High-Intensity Focused Ultrasound (HIFU) is a promising field of research being developed
as an alternative to surgery and radiation therapy for the treatment of tumours.
Within this field, many current methods of calculation/simulation use approximations
rather than solve the Partial Differential Equation (PDE) directly. We consider the linear
acoustic equation with and without damping for a material with spatially varying properties.
Our approach used spectral methods to manage the derivatives and solve the PDE. We
started from the basics to tune our intuition for the problem. This allowed us to discuss
some effects of phenomenological damping and to study the effects of wave reflection and
refraction. Further, we were able to use these tools to investigate a possible cause of
unexpected heating found clinically. To this end we used spectral numerical methods to
solve the equation and applied stochastic analysis to examine the effects of variations in
a few of the relevant parameters (sound speeds and the radius of an anomaly) on the
outcome.
This model highlighted the fact that, due to the reflection and refraction of the ultrasound
waves, more heating may occur inside obstacles in the treatment path than previously
expected. The stochastic review found that discrepancies in the radius of the obstacle
has a much larger impact on the outcome of the HIFU treatment than discrepancies in the
parameters for the speed of sound in the various media. Thus more time and resources
should be allocated to properly mapping and measuring the size and shape of obstacles in
the treatment path as opposed to improving the exactness of the values for the speeds of
sound.
Subjects/Keywords: Ultrasound; HIFU; Refraction
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APA (6th Edition):
Burnett, L. (2019). Wave Refraction Effects in High Intensity Focused Ultrasound. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/14376
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Burnett, Lauren. “Wave Refraction Effects in High Intensity Focused Ultrasound.” 2019. Thesis, University of Waterloo. Accessed January 21, 2021.
http://hdl.handle.net/10012/14376.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Burnett, Lauren. “Wave Refraction Effects in High Intensity Focused Ultrasound.” 2019. Web. 21 Jan 2021.
Vancouver:
Burnett L. Wave Refraction Effects in High Intensity Focused Ultrasound. [Internet] [Thesis]. University of Waterloo; 2019. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/10012/14376.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Burnett L. Wave Refraction Effects in High Intensity Focused Ultrasound. [Thesis]. University of Waterloo; 2019. Available from: http://hdl.handle.net/10012/14376
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
11.
Tremblay-Darveau, Charles.
Measuring Blood Pressure using Microbubbles and Ultrasound.
Degree: 2011, University of Toronto
URL: http://hdl.handle.net/1807/31610
► Gas microbubbles have a high compressibility, which make them very efficient sound scatterers. As another consequence of their high compressibility, microbubbles can be compressed by…
(more)
▼ Gas microbubbles have a high compressibility, which make them very efficient sound scatterers. As another consequence of their high compressibility, microbubbles can be compressed by the pressure of the fluid around them, which affects their scattering properties. Due to recent progress in shelled ultrasound contrast agents and the development of almost monodispersed microbubbles, we believe it could now be possible to measure blood pressure using microbubbles as non-invasive manometers, an idea first suggested more than 30 years ago. In this thesis, both simulations and in vitro experiments will be used to investigate the changes related to the resonance of bubbles and how the concept of bubble size population affects the accuracy of this technique. In particular, it will be shown how shell dynamics dominates the response of microbubbles to blood pressure.
MAST
Advisors/Committee Members: Burns, Peter N., Medical Biophysics.
Subjects/Keywords: Ultrasound; Microbubbles; 0605
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APA (6th Edition):
Tremblay-Darveau, C. (2011). Measuring Blood Pressure using Microbubbles and Ultrasound. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/31610
Chicago Manual of Style (16th Edition):
Tremblay-Darveau, Charles. “Measuring Blood Pressure using Microbubbles and Ultrasound.” 2011. Masters Thesis, University of Toronto. Accessed January 21, 2021.
http://hdl.handle.net/1807/31610.
MLA Handbook (7th Edition):
Tremblay-Darveau, Charles. “Measuring Blood Pressure using Microbubbles and Ultrasound.” 2011. Web. 21 Jan 2021.
Vancouver:
Tremblay-Darveau C. Measuring Blood Pressure using Microbubbles and Ultrasound. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1807/31610.
Council of Science Editors:
Tremblay-Darveau C. Measuring Blood Pressure using Microbubbles and Ultrasound. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/31610
Queensland University of Technology
12.
Khoei, Shadi.
Quantitative ultrasound computed tomography imaging of PAGAT radiation dosimetry gel.
Degree: 2013, Queensland University of Technology
URL: https://eprints.qut.edu.au/63958/
► This research developed and scientifically validated a new ultrasound transmission computed tomography system with the aim of quantitative assessment of a polymer gel dosimeter including…
(more)
▼ This research developed and scientifically validated a new ultrasound transmission computed tomography system with the aim of quantitative assessment of a polymer gel dosimeter including dose response verification of ultrasonic parameters of attenuation, velocity and broadband ultrasound attenuation (BUA). This work was the first to investigate and report ultrasound frequency dependent attenuation in a gel dosimeter, demonstrating a dose dependence.
Subjects/Keywords: Ultrasound computed tomography; Ultrasound attenuation; Broadband ultrasound attenuation; Ultrasound imaging; Polymer gel dosimetry
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Khoei, S. (2013). Quantitative ultrasound computed tomography imaging of PAGAT radiation dosimetry gel. (Thesis). Queensland University of Technology. Retrieved from https://eprints.qut.edu.au/63958/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Khoei, Shadi. “Quantitative ultrasound computed tomography imaging of PAGAT radiation dosimetry gel.” 2013. Thesis, Queensland University of Technology. Accessed January 21, 2021.
https://eprints.qut.edu.au/63958/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Khoei, Shadi. “Quantitative ultrasound computed tomography imaging of PAGAT radiation dosimetry gel.” 2013. Web. 21 Jan 2021.
Vancouver:
Khoei S. Quantitative ultrasound computed tomography imaging of PAGAT radiation dosimetry gel. [Internet] [Thesis]. Queensland University of Technology; 2013. [cited 2021 Jan 21].
Available from: https://eprints.qut.edu.au/63958/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Khoei S. Quantitative ultrasound computed tomography imaging of PAGAT radiation dosimetry gel. [Thesis]. Queensland University of Technology; 2013. Available from: https://eprints.qut.edu.au/63958/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
13.
Wright, Cameron.
An Investigation into Focused Ultrasound Thrombolysis.
Degree: 2010, University of Toronto
URL: http://hdl.handle.net/1807/25522
► In this thesis focused ultrasound thrombolysis was investigated in vitro and in vivo. At high intensities it was demonstrated that clot breakdown only arises under…
(more)
▼ In this thesis focused ultrasound thrombolysis was investigated in vitro and in vivo. At high intensities it was demonstrated that clot breakdown only arises under the presence of inertial cavitation for longer pulse lengths, consistent with observations at significantly shorter pulse durations, and that the majority of clot debris is sub-capillary in size. Evidence of flow restoration was demonstrated in vivo by partially restoring flow to an occluded rabbit femoral artery. At slightly lower intensities it was observed that steady- state clot displacements scale linearly with power for clots treated with focused ultrasound pulses, and in some cases can reach magnitudes up to several hundred microns. It was demonstrated that the shear strain exerted on the clot by a focused ultrasound pulse scale with power, which may be implicated in enhancing drug permeation for studies in combination with lytic agents.
MAST
Advisors/Committee Members: Goertz, David, Medical Biophysics.
Subjects/Keywords: Ultrasound; Thrombolysis; 0760
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APA (6th Edition):
Wright, C. (2010). An Investigation into Focused Ultrasound Thrombolysis. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/25522
Chicago Manual of Style (16th Edition):
Wright, Cameron. “An Investigation into Focused Ultrasound Thrombolysis.” 2010. Masters Thesis, University of Toronto. Accessed January 21, 2021.
http://hdl.handle.net/1807/25522.
MLA Handbook (7th Edition):
Wright, Cameron. “An Investigation into Focused Ultrasound Thrombolysis.” 2010. Web. 21 Jan 2021.
Vancouver:
Wright C. An Investigation into Focused Ultrasound Thrombolysis. [Internet] [Masters thesis]. University of Toronto; 2010. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1807/25522.
Council of Science Editors:
Wright C. An Investigation into Focused Ultrasound Thrombolysis. [Masters Thesis]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/25522
University of Toronto
14.
Lee, Justin.
High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment.
Degree: 2010, University of Toronto
URL: http://hdl.handle.net/1807/25778
► There is a need for cancer imaging to provide “real-time” information about the cellular responses of tumours in contrast to standard evaluations of tumour size.…
(more)
▼ There is a need for cancer imaging to provide “real-time” information about the cellular responses of tumours in contrast to standard evaluations of tumour size. Quantitative ultrasound techniques have recently been demonstrated to be a potential method of assessing tumour response at the cellular level through the analysis of radiofrequency backscatter data.
In this thesis, prostate cancer xenografts were evaluated in vivo using high-frequency ultrasound analysis techniques to assess tumour response. The anti-cancer treatments consisted of radiotherapy and also a novel anti-vascular therapy utilizing encapsulated microbubble agents in the presence of ultrasound. Quantitative ultrasound results demonstrated a statistically significant change in backscatter parameters in tumours treated with high doses of radiotherapy or a high concentration of microbubbles during treatments. Histopathological assessment demonstrated that tumour cell death due to apoptosis and necrosis correlated with increases in ultrasound parameters.
MAST
Advisors/Committee Members: Czarnota, Gregory J., Medical Biophysics.
Subjects/Keywords: ULTRASOUND; CANCER; MEDICAL
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Export
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Manager
APA (6th Edition):
Lee, J. (2010). High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/25778
Chicago Manual of Style (16th Edition):
Lee, Justin. “High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment.” 2010. Masters Thesis, University of Toronto. Accessed January 21, 2021.
http://hdl.handle.net/1807/25778.
MLA Handbook (7th Edition):
Lee, Justin. “High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment.” 2010. Web. 21 Jan 2021.
Vancouver:
Lee J. High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment. [Internet] [Masters thesis]. University of Toronto; 2010. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1807/25778.
Council of Science Editors:
Lee J. High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment. [Masters Thesis]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/25778
AUT University
15.
Oldfield, Christie Erin.
Ultrasound imaging of the distal radioulnar joint: a new method to assess ulna radial translation in forearm rotation
.
Degree: 2013, AUT University
URL: http://hdl.handle.net/10292/5164
► The current study was conducted to establish normal values of Distal radioulnar joint (DRUJ) translation using ultrasound imaging (USI). Repeatability of quantifying DRUJ translation of…
(more)
▼ The current study was conducted to establish normal values of Distal radioulnar joint (DRUJ) translation using
ultrasound imaging (USI). Repeatability of quantifying DRUJ translation of the forearm in various positions using USI was additionally investigated. Lastly the data collected was compared to previously documented values established in the literature using Computerised Tomography (CT) imaging. It is fundamental to further clinical research in this area to ascertain the validity of using USI to quantify DRUJ translation in a normal population.
A cross-sectional reliability study was conducted with 23 normal participants.
Ultrasound examination was conducted bilaterally on two separate occasions, using the Phillips iU22 diagnostic
ultrasound machine. Static transverse images of maximal supination, neutral and maximal pronation, were taken three times. This process was repeated with the participant gripping a 1kg weight for the supination and pronation positions. Using the Sketchbook Express software programme, lines were drawn to assess the relative distance of known bony landmarks. This method is consistent with the rheumatoid arthritis subluxation ratio (RASR) described by Henmi et al. (2007). Statistical analyses of repeatability included a hierarchical mixed model method, analysis of variance (ANOVA) and Cronbach’s alpha. Validity was also assessed comparing data to previously documented values in CT literature.
Translation was found to occur in both non gripping supination and pronation compared with neutral (p<0.001). There was statistically significantly more translation found with pronation (mean=1.69mm). Ulna radial translation in supination was found to occur to a lesser extent and in a volar direction compared with neutral (mean=0.67mm). Gripping pronation did not produce statistically significant changes compared to non gripping pronation. However, gripping supination was significantly higher (p<0.01) in comparison to non gripping supination. Cronbach’s alpha measurement for internal consistency was very high (0.9). Other than forearm position, there was no statistically significant difference between hand, left versus right, state or session. The RASR values in the current study demonstrated consistent measurements when compared to previously documented values.
This study demonstrated that USI can reliably detect translatory movement of the DRUJ in healthy participants. It supports the role of USI in future musculoskeletal applications and research. Alternative methods to accurately record translation may provide a less expensive and more accessible diagnostic tool in assessing DRUJ instability. This would reduce the dependence on CT or magnetic resonance imaging (MRI) scans to diagnose DRUJ instability in patients after trauma, inflammatory joint diseases or developmental disorders.
Advisors/Committee Members: Hing, Wayne (advisor).
Subjects/Keywords: DRUJ;
Ultrasound imaging
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APA (6th Edition):
Oldfield, C. E. (2013). Ultrasound imaging of the distal radioulnar joint: a new method to assess ulna radial translation in forearm rotation
. (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/5164
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Oldfield, Christie Erin. “Ultrasound imaging of the distal radioulnar joint: a new method to assess ulna radial translation in forearm rotation
.” 2013. Thesis, AUT University. Accessed January 21, 2021.
http://hdl.handle.net/10292/5164.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Oldfield, Christie Erin. “Ultrasound imaging of the distal radioulnar joint: a new method to assess ulna radial translation in forearm rotation
.” 2013. Web. 21 Jan 2021.
Vancouver:
Oldfield CE. Ultrasound imaging of the distal radioulnar joint: a new method to assess ulna radial translation in forearm rotation
. [Internet] [Thesis]. AUT University; 2013. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/10292/5164.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Oldfield CE. Ultrasound imaging of the distal radioulnar joint: a new method to assess ulna radial translation in forearm rotation
. [Thesis]. AUT University; 2013. Available from: http://hdl.handle.net/10292/5164
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Oxford
16.
Beguin, Estelle.
Sonodynamic therapy of hypoxic tumours.
Degree: PhD, 2018, University of Oxford
URL: http://ora.ox.ac.uk/objects/uuid:d9583dbf-6d0c-4613-9ad4-f5329f95f41c
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780539
► Improvements in cancer therapies have enabled a steady increase in the five-year survival rates of patients with most tumour types. Yet, some highly aggressive tumours…
(more)
▼ Improvements in cancer therapies have enabled a steady increase in the five-year survival rates of patients with most tumour types. Yet, some highly aggressive tumours still present resistance to conventional cancer therapies. One of the explanations for this has been ascribed to the low levels of oxygen seen in the tumours' vicinity. In this manuscript, the development of sonodynamic therapy to enable the treatment of hypoxic pancreatic tumours is presented. With this technique, low intensity ultrasound is used to activate oxygen-loaded microbubbles in order to provide oxygen in hypoxic lesions and enable their treatment using an ultrasound-responsive drug: Rose Bengal. An investigation on mechanisms demonstrated that light generated from collapsing microbubbles allows the activation of Rose Bengal during ultrasound exposure. Several acoustic parameters were also evaluated to understand their impact on treatment. To enhance the delivery of oxygen and the sonodynamic effect, magnetic targeting of microbubbles was enabled by incorporating iron oxide nanoparticles within their coating. Thus, an external magnetic field focused at the tumour can be used to target this therapy. A structural analysis of microbubbles as drug and oxygen carrier was then undertaken to optimise the system's stability and performance. An evaluation of this method in preclinical in vivo experiments demonstrated that magnetically targeted sonodynamic therapy with oxygen microbubbles and Rose Bengal enabled a decrease in size of hypoxic pancreatic tumours in a murine model. Therefore, this thesis presents promising results for the treatment of hypoxic tumours using sonodynamic therapy, as well as key mechanistic and parametric results to enable the further optimisation of this method for clinical use.
Subjects/Keywords: Ultrasound; Sonodynamic therapy
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Manager
APA (6th Edition):
Beguin, E. (2018). Sonodynamic therapy of hypoxic tumours. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:d9583dbf-6d0c-4613-9ad4-f5329f95f41c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780539
Chicago Manual of Style (16th Edition):
Beguin, Estelle. “Sonodynamic therapy of hypoxic tumours.” 2018. Doctoral Dissertation, University of Oxford. Accessed January 21, 2021.
http://ora.ox.ac.uk/objects/uuid:d9583dbf-6d0c-4613-9ad4-f5329f95f41c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780539.
MLA Handbook (7th Edition):
Beguin, Estelle. “Sonodynamic therapy of hypoxic tumours.” 2018. Web. 21 Jan 2021.
Vancouver:
Beguin E. Sonodynamic therapy of hypoxic tumours. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Jan 21].
Available from: http://ora.ox.ac.uk/objects/uuid:d9583dbf-6d0c-4613-9ad4-f5329f95f41c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780539.
Council of Science Editors:
Beguin E. Sonodynamic therapy of hypoxic tumours. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:d9583dbf-6d0c-4613-9ad4-f5329f95f41c ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780539
University of Oxford
17.
Rademeyer, Paul.
A new technique for microbubble characterisation and the implications to contrast enhanced ultrasound.
Degree: PhD, 2016, University of Oxford
URL: https://ora.ox.ac.uk/objects/uuid:2f5b0002-83e0-4251-b69a-de78c9895277
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730488
► The utility of microbubble agents in a variety of diagnostic and therapeutic ultrasound techniques has been widely demonstrated, most notably in Contrast Enhanced Ultrasound (CEUS)…
(more)
▼ The utility of microbubble agents in a variety of diagnostic and therapeutic ultrasound techniques has been widely demonstrated, most notably in Contrast Enhanced Ultrasound (CEUS) imaging. Unfortunately, the underlying mechanisms of their response to ultrasound excitation are poorly understood, restricting the development of promising techniques, such as quantitative perfusion imaging. A significant reason for this is that current microbubble characterisation techniques suffer from one or more of the following limitations: i) large experimental uncertainties, ii) physical restrictions on microbubble response and iii) failure to provide large data sets suitable for statistical analysis. This thesis presents a new technique to overcome these limitations. A co-axial microfluidic device is used to hydrodynamically confine microbubbles through the focal region of a laser and ultrasound field. The magnitude of light scattered by isolated microbubbles during ultrasound excitation is converted to radius using Mie Scattering theory. This technique is capable of obtaining large samples (>103/min) of microbubbles to be efficiently characterised. The response of a commercial contrast agent, SonoVue®, is first investigated for a range of ultrasound exposure parameters; frequency (2 MHz - 4.5 MHz), peak negative pressure (6 kPa - 400 kPa) and pulse length (3 cycles - 8 cycles). Second the device is used to investigate the effect of composition and fabrication on microbubble response to similar ultrasound conditions. The results demonstrate a very large variability in microbubble response independent of initial size, indicating a significant lack of uniformity of coating properties. This is further supported by quantitative fluorescence imaging and quasi-static pressure chamber measurements. The implications of the findings for CEUS imaging and the development of microbubble contrast agents are discussed, as well as the limitations and suggested improvements of the characterisation technique.
Subjects/Keywords: 616.07; Ultrasound Imaging; Biomedical engineering; Contrast Enhanced Ultrasound; Ultrasound Contrast Agents; Microbubbles; Characterisation; Ultrasound
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rademeyer, P. (2016). A new technique for microbubble characterisation and the implications to contrast enhanced ultrasound. (Doctoral Dissertation). University of Oxford. Retrieved from https://ora.ox.ac.uk/objects/uuid:2f5b0002-83e0-4251-b69a-de78c9895277 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730488
Chicago Manual of Style (16th Edition):
Rademeyer, Paul. “A new technique for microbubble characterisation and the implications to contrast enhanced ultrasound.” 2016. Doctoral Dissertation, University of Oxford. Accessed January 21, 2021.
https://ora.ox.ac.uk/objects/uuid:2f5b0002-83e0-4251-b69a-de78c9895277 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730488.
MLA Handbook (7th Edition):
Rademeyer, Paul. “A new technique for microbubble characterisation and the implications to contrast enhanced ultrasound.” 2016. Web. 21 Jan 2021.
Vancouver:
Rademeyer P. A new technique for microbubble characterisation and the implications to contrast enhanced ultrasound. [Internet] [Doctoral dissertation]. University of Oxford; 2016. [cited 2021 Jan 21].
Available from: https://ora.ox.ac.uk/objects/uuid:2f5b0002-83e0-4251-b69a-de78c9895277 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730488.
Council of Science Editors:
Rademeyer P. A new technique for microbubble characterisation and the implications to contrast enhanced ultrasound. [Doctoral Dissertation]. University of Oxford; 2016. Available from: https://ora.ox.ac.uk/objects/uuid:2f5b0002-83e0-4251-b69a-de78c9895277 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730488
KTH
18.
Janjic, Jovana.
Design of an In-vitro Set-up for Sonothrombolysis of human blood clots using microbubbles.
Degree: Technology and Health (STH), 2013, KTH
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123781
► Several studies suggest that the use of ultrasound in conjunction with microbubbles (MBs) can induce the lysis of the blood clots through acoustic cavitation…
(more)
▼ Several studies suggest that the use of ultrasound in conjunction with microbubbles (MBs) can induce the lysis of the blood clots through acoustic cavitation and through the production of microjets and microstreaming. However, there is no accordance about the optimal ultrasound parameters that have to be considered in order to achieve the maximum thrombolytic effect, neither a clear agreement about the type of MBs that have to be used. This project had two main goals: the design and optimization of an in-vitro set-up for the study of clot lysis within coronary arteries and its testing with ultrasound in conjunction with two different types of MBs. The MBs considered were the 3MiCRON MBs and the SonoVue MBs. The ultrasound sequence was developed using a programmable ultrasound architecture (Verasonics, Inc) and was tested using commercially available clinical transducers. Using the designed set-up and varying the ultrasound parameters (frequency, pulse length and pulse amplitude) it was possible to study the clot lysis effciency in conjunction with the two types of MBs. For the 3MiCRON MBs no increase in clot lysis was found with the implemented ultrasound parameters, while considering the SonoVue MBs, a 10% increase in clot lysis was found with 10ms long pulse delivered at 50V (peak-to peak value). The obtained set-up had several aspects in common with the real situation of occluded coronary arteries, although some limitations were present and further optimizations are required. Further work is required in order to assess if different combination of ultrasound parameters are able to lead to an increase in clot lysis when delivered with 3MiCRON or SonoVue MBs.
Subjects/Keywords: Ultrasound; microbubbles; thrombolysis
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APA (6th Edition):
Janjic, J. (2013). Design of an In-vitro Set-up for Sonothrombolysis of human blood clots using microbubbles. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123781
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Janjic, Jovana. “Design of an In-vitro Set-up for Sonothrombolysis of human blood clots using microbubbles.” 2013. Thesis, KTH. Accessed January 21, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123781.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Janjic, Jovana. “Design of an In-vitro Set-up for Sonothrombolysis of human blood clots using microbubbles.” 2013. Web. 21 Jan 2021.
Vancouver:
Janjic J. Design of an In-vitro Set-up for Sonothrombolysis of human blood clots using microbubbles. [Internet] [Thesis]. KTH; 2013. [cited 2021 Jan 21].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123781.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Janjic J. Design of an In-vitro Set-up for Sonothrombolysis of human blood clots using microbubbles. [Thesis]. KTH; 2013. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123781
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Urbana-Champaign
19.
Goodall, Elisabeth Frieda Peters.
Comparative imaging of surgical small intestinal disease in dogs: evaluation of pre-operative contrast-enhanced ultrasound, intra-operative contrast-enhanced ultrasound, and triple-phase contrast-enhanced computed tomography.
Degree: MS, VMS-Veterinary Clinical Medicine, 2016, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/90791
► Surgical small intestinal diseases occur commonly in canine patients seen in veterinary practices. Failure to identify ischemic tissue intra-operatively can result in surgical dehiscence, require…
(more)
▼ Surgical small intestinal diseases occur commonly in canine patients seen in veterinary practices. Failure to identify ischemic tissue intra-operatively can result in surgical dehiscence, require surgical revision, and lead to sepsis or death. Currently contrast-enhanced computed tomography (CT) is the standard of care for evaluating ischemic lesions of the bowel in humans. Contrast-enhanced
ultrasound (CEUS) is an alternative method for evaluating tissue perfusion whose utility for evaluation of canine small intestinal lesions remains to be fully tested. Thirteen client-owned dogs were prospectively recruited after presenting with surgical diseases within the small intestine. Presenting conditions included discrete foreign bodies, linear foreign bodies, intestinal abscess, and neoplasia. Patients underwent pre-operative CEUS, triple-phase contrast-enhanced CT, and intra-operative CEUS. Surgical specimens obtained from each patient included resected intestinal segments or biopsy. Both CT and CEUS data were compared to histopathology findings. All patients that required a resection (n=4) received an ischemia score of 4 or 5. A higher ischemia score was correlated with an increased chance of necrosis (p=0.003) and thrombosis (p=0.024). The presence of a visual perfusion deficit on CT was correlated with a higher ischemia grade (p=0.048) and higher chance of necrosis (p=0.024); however, observers only detected a perfusion deficit in 3/4 (75%) of patients requiring a resection. Ischemia was correlated with lower Hounsfield (HU) values aborad to the lesion in the pre-contrast CT (p=0.049). Necrosis was correlated with increased HU values at normal intestine in the arterial phase (p=0.017) and orad to the lesion in the venous phase of CT (p=0.014). Thrombosis was correlated with lower HU values aborad to the lesion in the pre-contrast CT (p=0.025) and higher HU values at normal intestine in the arterial phase (p=0.037) and orad to the lesion in the venous phase CT (p=0.041). Edema was correlated with lower HU values aborad to the lesion in the arterial phase (p=0.03) and higher HU values at normal intestine in the venous phase CT (p=0.038). Ulceration and erosion were correlated with higher HU values orad to the lesion in both the arterial (p=0.028) and venous phases of CT (p=0.044). No significant correlations were found at the site of the lesion in any phase of CT. For pre-operative CEUS, edema was correlated with higher peak intensity (p=0.014) while necrosis (p=0.046) and thrombosis (p=0.04) were correlated with a faster time to peak. For intra-operative CEUS, ulceration and erosion were correlated with a greater inflow slope (p=0.045), hemorrhage was correlated with a longer time to initial rise (p=0.028), thrombosis was correlated with a faster time to peak (p=0.014), and necrosis was correlated with increased baseline pixel intensity (p=0.046). Observers were able to detect a perfusion deficit on CEUS exam in 4/4 (100%) of patients requiring a resection. No advantage to the intra-operative CEUS…
Advisors/Committee Members: Phillips, Heidi (advisor).
Subjects/Keywords: contrast-enhanced ultrasound
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APA (6th Edition):
Goodall, E. F. P. (2016). Comparative imaging of surgical small intestinal disease in dogs: evaluation of pre-operative contrast-enhanced ultrasound, intra-operative contrast-enhanced ultrasound, and triple-phase contrast-enhanced computed tomography. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/90791
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Goodall, Elisabeth Frieda Peters. “Comparative imaging of surgical small intestinal disease in dogs: evaluation of pre-operative contrast-enhanced ultrasound, intra-operative contrast-enhanced ultrasound, and triple-phase contrast-enhanced computed tomography.” 2016. Thesis, University of Illinois – Urbana-Champaign. Accessed January 21, 2021.
http://hdl.handle.net/2142/90791.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Goodall, Elisabeth Frieda Peters. “Comparative imaging of surgical small intestinal disease in dogs: evaluation of pre-operative contrast-enhanced ultrasound, intra-operative contrast-enhanced ultrasound, and triple-phase contrast-enhanced computed tomography.” 2016. Web. 21 Jan 2021.
Vancouver:
Goodall EFP. Comparative imaging of surgical small intestinal disease in dogs: evaluation of pre-operative contrast-enhanced ultrasound, intra-operative contrast-enhanced ultrasound, and triple-phase contrast-enhanced computed tomography. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2016. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/2142/90791.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Goodall EFP. Comparative imaging of surgical small intestinal disease in dogs: evaluation of pre-operative contrast-enhanced ultrasound, intra-operative contrast-enhanced ultrasound, and triple-phase contrast-enhanced computed tomography. [Thesis]. University of Illinois – Urbana-Champaign; 2016. Available from: http://hdl.handle.net/2142/90791
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Melbourne
20.
MOHD YUSOF, NOR SAADAH.
Ultrasonic modification of micelle structures.
Degree: 2015, University of Melbourne
URL: http://hdl.handle.net/11343/54635
► The tremendous attention given to micelle systems is due to its potential uses in many scientific, biomedical and industrial applications. Micellar aggregations possess unique ability…
(more)
▼ The tremendous attention given to micelle systems is due to its potential uses in many scientific, biomedical and industrial applications. Micellar aggregations possess unique ability to exhibit different physicochemical properties owing to their dynamic and reversible structural transformation. This flexibility is controllable by different stimuli. In this study, the possibility of designing a variety of micelle nanostructures using ultrasound is investigated. Using ultrasound as a stimulus is an advantage as it eliminates the needs of adding external chemicals to the micellar system, and experimental parameters could be easily controlled. The fundamental properties of micelles and various forces generated by ultrasound in liquids are discussed in Chapter 1.
The second chapter on Literature Review is structured in line with Results and Discussion chapters. In the first section, the use of a fluorescence based technique for the determination of critical micelle concentration as well as reported attempts in monitoring micelle structural changes are outlined. In the second section, literature dealing with structural changes in micelle systems by different stimuli is reviewed. The Reptation Reaction Model is discussed in detail in the following section. This section provides theoretical arguments on the reptation process of micelle, as well as the different reaction (recombination) routes that result in the formation of different structures of micelle. In the last section, sonochemical synthesis of gold nanoparticles is reviewed.
In Chapter 3, materials used, solution preparation methods, experimental approaches and analytical methods used are described. The micelle used in this study is cetyltrimethylammonium salicylate (CTASal) prepared by an ion exchange process between cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal). The ultrasonic settings chosen include different sonication reactors, frequency and applied power.
In Chapter 4, a fluorescence based technique using fluorescein isothiocyanate (FITC) as a probe to monitor structural changes in micelle was successfully implemented. The method was found to be successful in detecting the critical micelle concentration (cmc) as well as for monitoring the concentration dependent structural growth of CTAB micelle system. It was then tested to the sonicated CTASal micelle system. The limitation of this technique is also discussed in this chapter.
In Chapter 5, the first ultrasound-driven transformation of CTASal micelle structures is reported. The wormlike micelle formed from CTAB and NaSal was chosen due to the increasing interest of such viscoelastic micelles in recent technological applications. The sonication was carried out with a plate-type transducer at 211 kHz frequency. The wormlike micelle was found to transform to long threadlike micelle and vesicles/tubular micelle, simultaneously. These were confirmed by the cryo-TEM and rheological measurements. A mechanism for ultrasound induced micelle structural changes is proposed based on…
Subjects/Keywords: ultrasound; micelle; viscoelasticity
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APA (6th Edition):
MOHD YUSOF, N. S. (2015). Ultrasonic modification of micelle structures. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/54635
Chicago Manual of Style (16th Edition):
MOHD YUSOF, NOR SAADAH. “Ultrasonic modification of micelle structures.” 2015. Doctoral Dissertation, University of Melbourne. Accessed January 21, 2021.
http://hdl.handle.net/11343/54635.
MLA Handbook (7th Edition):
MOHD YUSOF, NOR SAADAH. “Ultrasonic modification of micelle structures.” 2015. Web. 21 Jan 2021.
Vancouver:
MOHD YUSOF NS. Ultrasonic modification of micelle structures. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/11343/54635.
Council of Science Editors:
MOHD YUSOF NS. Ultrasonic modification of micelle structures. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/54635
University of Georgia
21.
Mimbs, Kelly Jeannette.
The effects of Paylean on live animal performance, carcass cutability and quality, belly firmness and fatty acid composition of pigs sorted into prefinishing backfat classes using real-time ultrasound.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/21340
► One hundred forty - four finishing pigs were evaluated using real-time ultrasound and selected into fat and lean pens based on 10 th rib backfat…
(more)
▼ One hundred forty - four finishing pigs were evaluated using real-time ultrasound and selected into fat and lean pens based on 10 th rib backfat (fat difference > 0.5 cm). All pigs received a basal corn and soybean meal diet containing
18% crude protein and 1.1% lysine and half of the pens received Paylean supplementation of 10 ppm. Pigs were assignment to a 2 x 2 factorial arrangement with two backfat classes (lean and fat) and two levels of Paylean® supplementation (0 and 10ppm).
Paylean improved finishing performance by improving feed efficiency and decreasing feed intake but had no affect on average daily gain. Paylean supplementation improved quality and carcass composition. Fatty acid composition and iodine value between
ractopamine supplemented and control pigs were similar to those observed in lean versus fat pigs. Thus, Paylean was effective in improving live performance and lean growth while fat and belly quality was not diminished.
Subjects/Keywords: Paylean; Pork; Ultrasound
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APA (6th Edition):
Mimbs, K. J. (2014). The effects of Paylean on live animal performance, carcass cutability and quality, belly firmness and fatty acid composition of pigs sorted into prefinishing backfat classes using real-time ultrasound. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/21340
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mimbs, Kelly Jeannette. “The effects of Paylean on live animal performance, carcass cutability and quality, belly firmness and fatty acid composition of pigs sorted into prefinishing backfat classes using real-time ultrasound.” 2014. Thesis, University of Georgia. Accessed January 21, 2021.
http://hdl.handle.net/10724/21340.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mimbs, Kelly Jeannette. “The effects of Paylean on live animal performance, carcass cutability and quality, belly firmness and fatty acid composition of pigs sorted into prefinishing backfat classes using real-time ultrasound.” 2014. Web. 21 Jan 2021.
Vancouver:
Mimbs KJ. The effects of Paylean on live animal performance, carcass cutability and quality, belly firmness and fatty acid composition of pigs sorted into prefinishing backfat classes using real-time ultrasound. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/10724/21340.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mimbs KJ. The effects of Paylean on live animal performance, carcass cutability and quality, belly firmness and fatty acid composition of pigs sorted into prefinishing backfat classes using real-time ultrasound. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/21340
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia Tech
22.
Hantrakul, Lamtharn.
Regressing dexterous finger flexions using machine learning and multi-channel single element ultrasound transducers.
Degree: MS, Music, 2018, Georgia Tech
URL: http://hdl.handle.net/1853/61173
► Human Machine Interfaces or "HMI's" come in many shapes and sizes. The mouse and keyboard is a typical and familiar HMI. In applications such as…
(more)
▼ Human Machine Interfaces or "HMI's" come in many shapes and sizes. The mouse and keyboard is a typical and familiar HMI. In applications such as Virtual Reality or Music performance, a precise HMI for tracking finger movement is often required.
Ultrasound, a safe and non-invasive imaging technique, has shown great promise as an alternative HMI interface that addresses the shortcomings of vision-based and glove-based sensors. This thesis develops a first-in-class system enabling real-time regression of individual and simultaneous finger flexions using single element
ultrasound transducers. A comprehensive dataset of
ultrasound signals is collected is collected from a study of 10 users. A series of machine learning experiments using this dataset demonstrate promising results supporting the use of single element transducers as a HMI device.
Advisors/Committee Members: Weinberg, Gil (advisor).
Subjects/Keywords: Machine learning; Ultrasound
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APA (6th Edition):
Hantrakul, L. (2018). Regressing dexterous finger flexions using machine learning and multi-channel single element ultrasound transducers. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/61173
Chicago Manual of Style (16th Edition):
Hantrakul, Lamtharn. “Regressing dexterous finger flexions using machine learning and multi-channel single element ultrasound transducers.” 2018. Masters Thesis, Georgia Tech. Accessed January 21, 2021.
http://hdl.handle.net/1853/61173.
MLA Handbook (7th Edition):
Hantrakul, Lamtharn. “Regressing dexterous finger flexions using machine learning and multi-channel single element ultrasound transducers.” 2018. Web. 21 Jan 2021.
Vancouver:
Hantrakul L. Regressing dexterous finger flexions using machine learning and multi-channel single element ultrasound transducers. [Internet] [Masters thesis]. Georgia Tech; 2018. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1853/61173.
Council of Science Editors:
Hantrakul L. Regressing dexterous finger flexions using machine learning and multi-channel single element ultrasound transducers. [Masters Thesis]. Georgia Tech; 2018. Available from: http://hdl.handle.net/1853/61173
Texas A&M University
23.
Shajudeen, Peer Mohamed Shafeeq.
Ultrasound Three-Dimensional Surface Rendering with Elastography-Based Fracture Localization of the Spine.
Degree: PhD, Electrical Engineering, 2018, Texas A&M University
URL: http://hdl.handle.net/1969.1/188953
► Ultrasound (US) has recently emerged as an attractive imaging modality for applications like accurate epidural placement and intraoperative guidance during surgeries. However, operators like anesthesiologists…
(more)
▼ Ultrasound (US) has recently emerged as an attractive imaging modality for applications like
accurate epidural placement and intraoperative guidance during surgeries. However, operators like
anesthesiologists or surgeons untrained in US have difficulty interpreting the anatomy in noisy
spinal US images. This problem is exacerbated by presence of fractures which is integral to the
assessment of spinal cord injuries and stability. A method to automatically isolate and perform a
3D rendering of the spine anatomy from scanned US images is proposed. In the case of fractures,
ultrasound elastography techniques are proposed by assessing the mechanical response to a
uniaxial compression at the posterior vertebra-soft tissue boundary.
Experiments are performed by scanning the lumbar and thoracic vertebrae of 17 healthy volunteers
BMI ranging from 19.5 to 27.9. A local phase-symmetry technique is applied to the US B-mode
images for enhancement of bone-like ridges and the spine blobs are subsequently classified. The
segmented spine surface from the blobs is compared against the radiologist’s manual delineation
of the spine surface. This performance assessment analysis is also consequently extended to 3D
surfaces. For investigating spine fractures, experiments are performed on ex-vivo rabbit lumbar
spine samples. 3D finite element models of the vertebra-soft tissue complex are generated to
simulate axial normal and shear strains. Also, experiments on the same samples are performed to
corroborate simulation findings. The numerical characteristics of axial strain’s spatial distribution
are further used to construct two shape descriptors to make inferences on spinal abnormalities.
The proposed techniques accurately generate a 3D surface rendering of multiple vertebrae
specifically showing landmarks like the laminae, ligamentum flava, spinous, transverse and
articular processes. These techniques are also extended for bone regeneration applications which
has implications for the monitoring of postoperative bone healing. Results from studies on spine
fractures indicate that the disruption of axial strains manifest as distinct patterns around intact and
fractured vertebrae. These along with the shape descriptor features resulting from the surrounding
soft tissue deformation can serve as a useful adjunct to B-mode images in uniquely determining
the location of fracture sites.
Advisors/Committee Members: righetti, raffaella (advisor), qian, xiaoning (committee member), datta, aniruddha (committee member), goenezen, sevan (committee member).
Subjects/Keywords: ultrasound; segmentation; elastography
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APA (6th Edition):
Shajudeen, P. M. S. (2018). Ultrasound Three-Dimensional Surface Rendering with Elastography-Based Fracture Localization of the Spine. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/188953
Chicago Manual of Style (16th Edition):
Shajudeen, Peer Mohamed Shafeeq. “Ultrasound Three-Dimensional Surface Rendering with Elastography-Based Fracture Localization of the Spine.” 2018. Doctoral Dissertation, Texas A&M University. Accessed January 21, 2021.
http://hdl.handle.net/1969.1/188953.
MLA Handbook (7th Edition):
Shajudeen, Peer Mohamed Shafeeq. “Ultrasound Three-Dimensional Surface Rendering with Elastography-Based Fracture Localization of the Spine.” 2018. Web. 21 Jan 2021.
Vancouver:
Shajudeen PMS. Ultrasound Three-Dimensional Surface Rendering with Elastography-Based Fracture Localization of the Spine. [Internet] [Doctoral dissertation]. Texas A&M University; 2018. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1969.1/188953.
Council of Science Editors:
Shajudeen PMS. Ultrasound Three-Dimensional Surface Rendering with Elastography-Based Fracture Localization of the Spine. [Doctoral Dissertation]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/188953
University of New South Wales
24.
Wang, Jingjing.
Automating the measurement of the foetal myocardial performance index using ultrasound images.
Degree: Graduate School of Biomedical Engineering, 2018, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/60057
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51304/SOURCE02?view=true
► Functional cardiovascular assessment is important in the study of fetal pathology, and is becom- ing an increasingly popular tool in clinical practice. The myocardial performance…
(more)
▼ Functional cardiovascular assessment is important in the study of fetal pathology, and is becom- ing an increasingly popular tool in clinical practice. The myocardial performance index (MPI) is one particularly important index for evaluating global myocardial function, as it combines assessment of both systolic and diastolic function and has been shown to be a sensitive indicator of cardiac dysfunction. Moreover, the MPI can be obtained non-invasively, and it is indepen- dent of ventricular geometry and heart rate. However, the current method for MPI calculation, which is obtained by manually annotating the time intervals required for the MPI calculation, can be time-consuming and demonstrates poor inter-operator repeatability; this is evidenced by a broad variation in normal ranges of MPI values reported in the literature. Therefore, there is motivation to develop an automated method for MPI calculation, which o↵ers a convenient and consistent way to estimate the MPI, hence making fetal cardiac functional evaluation based on the MPI easier and more reliable. In this thesis, automated fetal MPI calculation algorithms for both left and right ventricles have been developed by investigating manual measurement as well as exploring morphological characteristics of ultrasound images. The performance of these algorithms has been validated, demonstrating excellent agreement with aggregated manual an- notation performed by experts. These algorithms have also been deployed in clinical studies evaluating fetal MPI beat-to-beat variation, tissue Doppler-derived MPI, and developing normal MPI reference ranges.
Subjects/Keywords: Automation; Ultrasound; MPI
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APA (6th Edition):
Wang, J. (2018). Automating the measurement of the foetal myocardial performance index using ultrasound images. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60057 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51304/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Wang, Jingjing. “Automating the measurement of the foetal myocardial performance index using ultrasound images.” 2018. Doctoral Dissertation, University of New South Wales. Accessed January 21, 2021.
http://handle.unsw.edu.au/1959.4/60057 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51304/SOURCE02?view=true.
MLA Handbook (7th Edition):
Wang, Jingjing. “Automating the measurement of the foetal myocardial performance index using ultrasound images.” 2018. Web. 21 Jan 2021.
Vancouver:
Wang J. Automating the measurement of the foetal myocardial performance index using ultrasound images. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Jan 21].
Available from: http://handle.unsw.edu.au/1959.4/60057 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51304/SOURCE02?view=true.
Council of Science Editors:
Wang J. Automating the measurement of the foetal myocardial performance index using ultrasound images. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60057 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51304/SOURCE02?view=true
Ryerson University
25.
Mashouf, Shahram.
An Enhanced Numerical Model to Simulate Nonlinear Continuous Wave Ultrasound Propagation and the Resulting Temperature Response.
Degree: 2009, Ryerson University
URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A521
► In this work a nonlinear CW ultrasound field propagation model based on a second-order operator splitting approach is studied and a number of significant enhancements…
(more)
▼ In this work a nonlinear CW
ultrasound field propagation model based on a second-order operator splitting approach is studied and a number of significant enhancements are introduced and implemented. In this model the
ultrasound field is calculated and propagated plane by plane and the effects of diffraction, nonlinearity and absorption are applied independently over incremental steps. This work completes the preceding works (Christopher and Parker 1991, Tavakkoli et al. 1998, Zemp et al. 2003, Williams et al. 2006) by introducing an arbitrary source geometry and excitation definition, full diffraction solution, enhanced pressure, enhanced power deposition rate and temperature prediction capabilities. The result is a particularly useful tool in carrying out simulations of high intensity focused
ultrasound (HIFU) that includes temperature rise predictions. Comparisons are made with other codes in both linear and nonlinear regimes. Different dynamics of lesion formation are obtained in linear versus nonlinear models, specially at the onset of lesion creation during HIFU exposure.
Advisors/Committee Members: Tavakkoli, Jahan (Thesis advisor), Ryerson University (Degree grantor).
Subjects/Keywords: ultrasound; ultrasound field propagation model; high intensity focused ultrasound; hifu
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APA (6th Edition):
Mashouf, S. (2009). An Enhanced Numerical Model to Simulate Nonlinear Continuous Wave Ultrasound Propagation and the Resulting Temperature Response. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A521
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mashouf, Shahram. “An Enhanced Numerical Model to Simulate Nonlinear Continuous Wave Ultrasound Propagation and the Resulting Temperature Response.” 2009. Thesis, Ryerson University. Accessed January 21, 2021.
https://digital.library.ryerson.ca/islandora/object/RULA%3A521.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mashouf, Shahram. “An Enhanced Numerical Model to Simulate Nonlinear Continuous Wave Ultrasound Propagation and the Resulting Temperature Response.” 2009. Web. 21 Jan 2021.
Vancouver:
Mashouf S. An Enhanced Numerical Model to Simulate Nonlinear Continuous Wave Ultrasound Propagation and the Resulting Temperature Response. [Internet] [Thesis]. Ryerson University; 2009. [cited 2021 Jan 21].
Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A521.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mashouf S. An Enhanced Numerical Model to Simulate Nonlinear Continuous Wave Ultrasound Propagation and the Resulting Temperature Response. [Thesis]. Ryerson University; 2009. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A521
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Delft University of Technology
26.
Westhoek, Youri (author).
Ultrasound Energy Transfer using Charged CMUTs.
Degree: 2020, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:74a07486-73c2-4457-8261-7161acb46c60
► Implantable medical devices (IMDs) such as cardiac pacemakers, cochlear implants, and neurostimulators improve millions of people’s lives every day. Over the years, IMDs have significantly…
(more)
▼ Implantable medical devices (IMDs) such as cardiac pacemakers, cochlear implants, and neurostimulators improve millions of people’s lives every day. Over the years, IMDs have significantly improved in function, increased in lifetime, and decreased in size. However, further miniaturisation is limited by the batteries used to power these devices, and therefore methods to power them wirelessly are gaining in popularity. The technique most used to wirelessly power IMDs is electromagnetic energy transfer. However, at low frequencies, this method is limited to shallow implants due to its low directivity, while at high frequencies it is limited by attenuation in the human body. Therefore,
ultrasound energy may be the future of wirelessly powering implants. Its high directivity and low attenuation in the human body opens up the possibility to wirelessly power deep implants without any harmful side effects. An
ultrasound energy transfer set-up was established in this work to demonstrate that Philips’ capacitive micromachined
ultrasound transducers (CMUTs) can be used as
ultrasound energy harvesters. Normally, CMUTs need a bias voltage to function as an energy harvester. However, the CMUTs in this work are chargeable and therefore eliminate the need for this bias voltage. The results show that charged CMUTs can indeed be used as efficient energy harvesters of
ultrasound and that information can be sent back to the
ultrasound probe using echo modulation. The charged CMUTs showed to be able to harvest sufficient energy to stimulate a nerve and power a Bluetooth module, even when
ultrasound sent through 90mm of biological (pork) tissue. The maximum power harvested during the
ultrasound energy transfer experiments was 250mW over a transferring distance of 75mm.
Advisors/Committee Members: Dekker, R. (mentor), Kawasaki, S. (graduation committee), French, P.J. (graduation committee), Giagka, V. (graduation committee), Mastrangeli, M. (graduation committee), Delft University of Technology (degree granting institution).
Subjects/Keywords: Ultrasound Energy Transfer; Ultrasound Power Transfer; CMUT; Ultrasound Transducer; Wireless Energy Transfer; Wireless Power Transfer; Medical Devices; Ultrasound Imaging; Ultrasound Probe; Ultrasound; Capacitive Micromachined Ultrasound Transducers; Implantable Medical Devices (IMDs)
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APA (6th Edition):
Westhoek, Y. (. (2020). Ultrasound Energy Transfer using Charged CMUTs. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:74a07486-73c2-4457-8261-7161acb46c60
Chicago Manual of Style (16th Edition):
Westhoek, Youri (author). “Ultrasound Energy Transfer using Charged CMUTs.” 2020. Masters Thesis, Delft University of Technology. Accessed January 21, 2021.
http://resolver.tudelft.nl/uuid:74a07486-73c2-4457-8261-7161acb46c60.
MLA Handbook (7th Edition):
Westhoek, Youri (author). “Ultrasound Energy Transfer using Charged CMUTs.” 2020. Web. 21 Jan 2021.
Vancouver:
Westhoek Y(. Ultrasound Energy Transfer using Charged CMUTs. [Internet] [Masters thesis]. Delft University of Technology; 2020. [cited 2021 Jan 21].
Available from: http://resolver.tudelft.nl/uuid:74a07486-73c2-4457-8261-7161acb46c60.
Council of Science Editors:
Westhoek Y(. Ultrasound Energy Transfer using Charged CMUTs. [Masters Thesis]. Delft University of Technology; 2020. Available from: http://resolver.tudelft.nl/uuid:74a07486-73c2-4457-8261-7161acb46c60
University of California – Irvine
27.
Rooney, Kevin Patrick.
Prehospital Assessment with Ultrasound in Emergencies - PAUSE II - Implementation in the Field.
Degree: Biomedical Sciences, 2014, University of California – Irvine
URL: http://www.escholarship.org/uc/item/6sr829mx
► Background: Point-of-care ultrasound is an ideal imaging modality in the emergency department. Its study in the prehospital setting is limited. We previously published on paramedics'…
(more)
▼ Background: Point-of-care ultrasound is an ideal imaging modality in the emergency department. Its study in the prehospital setting is limited. We previously published on paramedics' ability to perform basic scans and recognize pneumothorax, pericardial effusion and cardiac standstill under classroom conditions. In this study, we trained paramedics to use cardiac ultrasound in the field.Objectives: To determine whether paramedics are capable of obtaining cardiac ultrasound scans at a level adequate for decision-making. The primary outcome was a percentage of paramedic scans judged as adequate for clinical decision-making. Methods: This was a prospective educational intervention using a convenience sample of professional paramedics with no prior US experience. Paramedics participated in a 3-hour training session then used US during dispatch calls. They saved scans for complaints of: chest pain, dyspnea, loss of consciousness, trauma, cardiac arrest. The scans were later evaluated by two ultrasound-trained emergency physicians.Results: Overall, four paramedics obtained adequate scans 89% of the time. In total, 17/19 unique patient studies were adequate for clinical decision-making. Two studies were of inadequate diagnostic quality. Two cardiac arrest studies were logged and paramedics correctly identified these cases as cardiac standstill.Conclusion: Implementing ultrasound in the prehospital setting is challenging. Many unforeseen variables interfered with the study. We did not achieve statistical significance, so the study must be interpreted as a hypothesis-generating study. Areas to improve in future studies include continuity of enrollment and data collection. Focus should be on improving outcomes in survival, quality and resource allocation.
Subjects/Keywords: Medicine; bedside ultrasound; paramedic; point of care ultrasound; prehospital care; sonography; ultrasound
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APA (6th Edition):
Rooney, K. P. (2014). Prehospital Assessment with Ultrasound in Emergencies - PAUSE II - Implementation in the Field. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/6sr829mx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rooney, Kevin Patrick. “Prehospital Assessment with Ultrasound in Emergencies - PAUSE II - Implementation in the Field.” 2014. Thesis, University of California – Irvine. Accessed January 21, 2021.
http://www.escholarship.org/uc/item/6sr829mx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rooney, Kevin Patrick. “Prehospital Assessment with Ultrasound in Emergencies - PAUSE II - Implementation in the Field.” 2014. Web. 21 Jan 2021.
Vancouver:
Rooney KP. Prehospital Assessment with Ultrasound in Emergencies - PAUSE II - Implementation in the Field. [Internet] [Thesis]. University of California – Irvine; 2014. [cited 2021 Jan 21].
Available from: http://www.escholarship.org/uc/item/6sr829mx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rooney KP. Prehospital Assessment with Ultrasound in Emergencies - PAUSE II - Implementation in the Field. [Thesis]. University of California – Irvine; 2014. Available from: http://www.escholarship.org/uc/item/6sr829mx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
28.
Chen, Kuiran.
An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
.
Degree: Computing, 2012, Queens University
URL: http://hdl.handle.net/1974/7614
► Image-guided surgeries employ advanced imaging and computing technologies to assist the surgeon when direct visualization is inadequate or unavailable. As modern surgeries continue to move…
(more)
▼ Image-guided surgeries employ advanced imaging and computing technologies to assist the surgeon when direct visualization is inadequate or unavailable. As modern surgeries continue to move toward minimally invasive procedures, tracked ultrasound (US), an emerging technology that uniquely combines US imaging and position tracking, has been increasingly used for intraoperative guidance in surgical interventions.
The intrinsic accuracy of a tracked US system is primarily determined by a unique procedure called ``probe calibration", where a spatial registration between the coordinate systems of the transducer (provided by a tracking device affixed to the probe) and the US image plane must be established prior to imaging. Inaccurate system calibration causes misalignments between the US image and the surgical end-effectors, which may directly contribute to treatment failure. The probe calibration quality is further reduced by the "elevation beamwidth" or "slice thickness", a unique feature of the ultrasound beam pattern that gives rise to localization errors and imaging uncertainties.
In this thesis, we aim to provide an automated, pure-computation-based, intraoperative calibration solution that also incorporates the slice thickness to improve the calibration accuracy, precision and reliability. The following contributions have been made during the course of this research. First, we have designed and developed an automated, freehand US calibration system with instant feedback on its calibration accuracy. The system was able to consistently achieve submillimeter accuracy with real-time performance.
Furthermore, we have developed a novel beamwidth-weighted calibration framework (USB-FW) that incorporates US slice thickness to improve the estimation of calibration parameters. The new framework provides an effective means of quality control for calibration results. Extensive phantom validation demonstrated that USB-FW introduces statistically significant reduction (p = 0.001) in the calibration errors and produces calibration outcomes that are less variable than a conventional, non-beamwidth-weighted calibration.
Finally, we were the first to introduce an automated, intraoperative Transrectal Ultrasound (TRUS) calibration technology for needle guidance in prostate brachytherapy. Our tests with multiple commercial TRUS scanners and brachytherapy stepper systems demonstrated that the proposed method is practical in use and can achieve high calibration accuracy, precision and robustness.
Subjects/Keywords: ultrasound elevation beamwidth
;
ultrasound slice thickness
;
probe calibration
;
image-guided surgery
;
tracked ultrasound
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APA (6th Edition):
Chen, K. (2012). An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7614
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chen, Kuiran. “An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
.” 2012. Thesis, Queens University. Accessed January 21, 2021.
http://hdl.handle.net/1974/7614.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chen, Kuiran. “An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
.” 2012. Web. 21 Jan 2021.
Vancouver:
Chen K. An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
. [Internet] [Thesis]. Queens University; 2012. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1974/7614.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chen K. An Automated Ultrasound Calibration Framework Incorporating Elevation Beamwidth for Tracked Ultrasound Interventions
. [Thesis]. Queens University; 2012. Available from: http://hdl.handle.net/1974/7614
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Rochester
29.
Castañeda Aphan, Benjamín (1978 - ).
Extracting information from sonoelastographic
images.
Degree: PhD, 2011, University of Rochester
URL: http://hdl.handle.net/1802/14529
► This thesis focuses on the implementation of image processing tools to extract information from images acquired with sonoelastography and crawling wave (CrW) sonoelastography. These algorithms…
(more)
▼ This thesis focuses on the implementation of image
processing tools to extract information from images acquired with
sonoelastography and crawling wave (CrW) sonoelastography. These
algorithms enhance the quality of the images; extract location and
size information of discrete lesions; and provide viscoelastic
properties of the imaged tissue. Among the implemented tools, a
semi-automated segmentation algorithm to measure discrete lesions
in sonoelastographic images is proposed and evaluated through
simulations, and experiments ex vivo and in vivo. The algorithm
reduces variability and processing time in the measurements while
keeping results comparable to manual segmentation. A second
algorithm to process CrW images is implemented to extract shear
velocity information from homogenous tissues. This
correlation-based algorithm is successfully applied to the
measurement of viscoelastic properties of human prostate ex vivo.
Finally, motion filtering and slow time processing are introduced
to enhance the quality of the CrW images by exploiting their
temporal and spatial harmonic properties. The proposed tools are
applied to two important clinical applications: prostate cancer
detection and measurement of thermally ablated lesions in liver. In
the former application, sonoelastography has an accuracy of over
80% for finding tumors larger than 4 mm in diameter, both in vivo
and ex vivo, and slightly underestimates their volumes. CrW
sonoelastography estimates the shear velocities of cancerous and
normal prostate tissue as 4.75±0.97 m/s and 3.26±0.87 m/s,
respectively. In the latter clinical application, results suggest
that sonoelastography has the potential to be used as a
complementary technique to conventional ultrasound for monitoring
thermal ablation and follow-up imaging.
Subjects/Keywords: Elasticity; Ultrasound; Crawling waves; Segmentation
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APA (6th Edition):
Castañeda Aphan, B. (. -. ). (2011). Extracting information from sonoelastographic
images. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/14529
Chicago Manual of Style (16th Edition):
Castañeda Aphan, Benjamín (1978 - ). “Extracting information from sonoelastographic
images.” 2011. Doctoral Dissertation, University of Rochester. Accessed January 21, 2021.
http://hdl.handle.net/1802/14529.
MLA Handbook (7th Edition):
Castañeda Aphan, Benjamín (1978 - ). “Extracting information from sonoelastographic
images.” 2011. Web. 21 Jan 2021.
Vancouver:
Castañeda Aphan B(-). Extracting information from sonoelastographic
images. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Jan 21].
Available from: http://hdl.handle.net/1802/14529.
Council of Science Editors:
Castañeda Aphan B(-). Extracting information from sonoelastographic
images. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/14529
Tulane University
30.
Harmon, Jonah.
Gas embolization as a minimally invasive therapy for the treatment of hepatocellular carcinoma.
Degree: 2020, Tulane University
URL: https://digitallibrary.tulane.edu/islandora/object/tulane:119707
► [email protected]
Hepatocellular carcinoma is an intractable cancer with a high mortality rate. Transarterial chemoembolization, a non-curative method, is the first line therapy for intermediate stage…
(more)
▼ [email protected]
Hepatocellular carcinoma is an intractable cancer with a high mortality rate. Transarterial chemoembolization, a non-curative method, is the first line therapy for intermediate stage patients. This effectively extends patient survival but requires a complicated intraarterial catheterization procedure and is poorly suited to repeated administration. Gas embolization has been proposed as a fast, easily administered, more spatially selective, and less invasive alternative. This process involves generating emboli in situ using acoustic droplet vaporization, the noninvasive focused ultrasound-mediated conversion of intravenously administered perfluorocarbon microdroplets into microbubbles. The work presented in this dissertation provides the first evidence of the feasibility and efficacy of gas embolization in vivo. Following confirmation of the cessation of tumor growth after treatment in a preliminary study, two additional preclinical studies were conducted. Varying treatment parameters and the use of systemic chemotherapy alongside gas embolization resulted in consistent, substantial tumor regression and a suppression of tumor recurrence following the cessation of treatment. Subsequent steps toward optimizing the treatment method, primarily intended to mitigate off-target tissue damage and to maximize the uniformity of treatment coverage across a lesion, involved the implementation of two specialized imaging modes for tumor detection and treatment planning and the development of an ultrasound-guided treatment method. Finally, retention of the lipid droplet shell upon vaporization was investigated in the context of selective targeting for localized drug delivery. The dissertation closes with a discussion of the implications of the presented work and proposed future studies.
1
Jonah Harmon
Advisors/Committee Members: Bull, Joseph (Thesis advisor), School of Science & Engineering Biomedical Engineering (Degree granting institution).
Subjects/Keywords: Embolotherapy; Ultrasound; Hepatocellular Carcinoma
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Manager
APA (6th Edition):
Harmon, J. (2020). Gas embolization as a minimally invasive therapy for the treatment of hepatocellular carcinoma. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:119707
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Harmon, Jonah. “Gas embolization as a minimally invasive therapy for the treatment of hepatocellular carcinoma.” 2020. Thesis, Tulane University. Accessed January 21, 2021.
https://digitallibrary.tulane.edu/islandora/object/tulane:119707.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Harmon, Jonah. “Gas embolization as a minimally invasive therapy for the treatment of hepatocellular carcinoma.” 2020. Web. 21 Jan 2021.
Vancouver:
Harmon J. Gas embolization as a minimally invasive therapy for the treatment of hepatocellular carcinoma. [Internet] [Thesis]. Tulane University; 2020. [cited 2021 Jan 21].
Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:119707.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Harmon J. Gas embolization as a minimally invasive therapy for the treatment of hepatocellular carcinoma. [Thesis]. Tulane University; 2020. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:119707
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
◁ [1] [2] [3] [4] [5] … [109] ▶
. 
Open Access Theses and Dissertations