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You searched for subject:(UGT1A4). Showing records 1 – 3 of 3 total matches.

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1. LIM SIOK LIU. Pharmacogenetics of Tamoxifen in Asian Breast Cancer Patients.

Degree: 2013, National University of Singapore

Subjects/Keywords: Pharmacogenetics; Tamoxifen; Breast Cancer; CYP2D6; UGT1A4; Asian

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

LIU, L. S. (2013). Pharmacogenetics of Tamoxifen in Asian Breast Cancer Patients. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/48644

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

LIU, LIM SIOK. “Pharmacogenetics of Tamoxifen in Asian Breast Cancer Patients.” 2013. Thesis, National University of Singapore. Accessed October 15, 2019. http://scholarbank.nus.edu.sg/handle/10635/48644.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

LIU, LIM SIOK. “Pharmacogenetics of Tamoxifen in Asian Breast Cancer Patients.” 2013. Web. 15 Oct 2019.

Vancouver:

LIU LS. Pharmacogenetics of Tamoxifen in Asian Breast Cancer Patients. [Internet] [Thesis]. National University of Singapore; 2013. [cited 2019 Oct 15]. Available from: http://scholarbank.nus.edu.sg/handle/10635/48644.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

LIU LS. Pharmacogenetics of Tamoxifen in Asian Breast Cancer Patients. [Thesis]. National University of Singapore; 2013. Available from: http://scholarbank.nus.edu.sg/handle/10635/48644

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidad de Extremadura

2. Gallego Aguilera, Alicia. Variabilidad interétnica de los polimorfismos genéticos de "UGT1A4" y "CYP2C9 IVS8-109 A>T" en las poblaciones española e iberoamericanas.

Degree: 2018, Universidad de Extremadura

Subjects/Keywords: UGT1A4; CYP2C9 IVS8-109 A>; T; Españoles; Diferencias interétnicas; Interethnic differences; Glucuronidación; Glucuronidation; Polimorfismos intrónicos; Intronic polymorphisms; 3208.09 Procesos Metabólicos de Los Medicamentos; 3201.02 Genética Clínica

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APA (6th Edition):

Gallego Aguilera, A. (2018). Variabilidad interétnica de los polimorfismos genéticos de "UGT1A4" y "CYP2C9 IVS8-109 A>T" en las poblaciones española e iberoamericanas. (Thesis). Universidad de Extremadura. Retrieved from http://hdl.handle.net/10662/2844

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gallego Aguilera, Alicia. “Variabilidad interétnica de los polimorfismos genéticos de "UGT1A4" y "CYP2C9 IVS8-109 A>T" en las poblaciones española e iberoamericanas.” 2018. Thesis, Universidad de Extremadura. Accessed October 15, 2019. http://hdl.handle.net/10662/2844.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gallego Aguilera, Alicia. “Variabilidad interétnica de los polimorfismos genéticos de "UGT1A4" y "CYP2C9 IVS8-109 A>T" en las poblaciones española e iberoamericanas.” 2018. Web. 15 Oct 2019.

Vancouver:

Gallego Aguilera A. Variabilidad interétnica de los polimorfismos genéticos de "UGT1A4" y "CYP2C9 IVS8-109 A>T" en las poblaciones española e iberoamericanas. [Internet] [Thesis]. Universidad de Extremadura; 2018. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/10662/2844.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gallego Aguilera A. Variabilidad interétnica de los polimorfismos genéticos de "UGT1A4" y "CYP2C9 IVS8-109 A>T" en las poblaciones española e iberoamericanas. [Thesis]. Universidad de Extremadura; 2018. Available from: http://hdl.handle.net/10662/2844

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Florida

3. Mohamed, Mohamed. Characterization of Herb-Drug Interactions through Glucuronidation.

Degree: PhD, Pharmaceutical Sciences - Pharmaceutics, 2010, University of Florida

The use of herbal supplements has continued to increase over the last decade. Many herbal supplement users concomitantly take prescription and non-prescription drugs, raising the potential for herb-drug interactions. Cytochrome P450-mediated herb-drug interactions have been reported in many studies. By contrast, the effects of herbal extracts on UDP-glucuronosyl transferase (UGT) enzymes have not been adequately studied. The goal of this research project was to identify commonly used herbal extracts that have potential to inhibit the glucuronidation pathway. First, we studied the effects of Ginkgo biloba extract and its major constituents on mycophenolic acid (MPA) glucuronidation. Ginkgo extract and its main flavonoid aglycones, quercetin and kaempferol, inhibited MPA glucuronidation in human liver and intestinal microsomal incubates. By comparing IC50 values to expected physiologic concentrations of ginkgo compounds in different body compartments, ginkgo extract is likely to inhibit MPA glucuronidation in the human intestine. The second aim was to identify herbal extracts that can potentially inhibit UGT1A1-mediated drug metabolism. A screening in human liver microsomes (HLM) was performed with commonly used herbal extracts to assess the potential for inhibition of UGT1A1 activity. Milk thistle extract and the green tea catechin epigallocatechin gallate (EGCG) were found to be potential inhibitors of first pass metabolism of UGT1A1 substrates. Among the extracts screened, EGCG exhibited the most potent inhibition. Therefore, we examined the effect of EGCG on intrinsic intestinal clearance of raloxifene, a substrate for intestinal glucuronidation by UGT1A1. EGCG exhibited concentration-dependent inhibition of raloxifene in vitro intestinal clearance, suggesting that green tea extracts may increase raloxifene oral bioavailability if taken concomitantly. Lastly, we screened commonly used herbal supplements for their effects on UGT1A4, 1A6, and 1A9 activities in HLM. In vitro inhibitors were EGCG for UGT1A4, milk thistle for both UGT1A6 and UGT1A9, saw palmetto for UGT1A6, and cranberry for UGT1A9. In conclusion, this project shows that commonly used herbal supplements may inhibit UGT-mediated drug metabolism. Based on observed inhibitory potency and predicted or known concentrations, glucuronidation is more likely to be affected in the intestine than the liver. The observed herb-UGT interactions warrant further research to investigate the pharmacokinetic consequences and clinical significance. ( en ) Advisors/Committee Members: Frye, Reginald F. (committee chair), Butterweck, Veronika (committee member), Hochhaus, Guenther (committee member), Shuster, Jonathan J. (committee member).

Subjects/Keywords: Dosage; Drug interactions; Enzymes; Green teas; Herb drug interactions; In vitro fertilization; Incubation; Inhibitory concentration 50; Metabolism; Milk; cohosh, cranberry, echinacea, egcg, garlic, ginkgo, ginseng, glucuronidation, herb, incubation, inhibition, interactions, intestine, liver, metabolism, microsomes, mpa, palmetto, pharmacokinetics, phytochemicals, raloxifene, saw, tea, thistle, ugt, ugt1a, ugt1a1, ugt1a4, ugt1a6, ugt1a9, valerian

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mohamed, M. (2010). Characterization of Herb-Drug Interactions through Glucuronidation. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0041440

Chicago Manual of Style (16th Edition):

Mohamed, Mohamed. “Characterization of Herb-Drug Interactions through Glucuronidation.” 2010. Doctoral Dissertation, University of Florida. Accessed October 15, 2019. http://ufdc.ufl.edu/UFE0041440.

MLA Handbook (7th Edition):

Mohamed, Mohamed. “Characterization of Herb-Drug Interactions through Glucuronidation.” 2010. Web. 15 Oct 2019.

Vancouver:

Mohamed M. Characterization of Herb-Drug Interactions through Glucuronidation. [Internet] [Doctoral dissertation]. University of Florida; 2010. [cited 2019 Oct 15]. Available from: http://ufdc.ufl.edu/UFE0041440.

Council of Science Editors:

Mohamed M. Characterization of Herb-Drug Interactions through Glucuronidation. [Doctoral Dissertation]. University of Florida; 2010. Available from: http://ufdc.ufl.edu/UFE0041440

.