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You searched for subject:(Typhoid Virus Proteins). Showing records 1 – 2 of 2 total matches.

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Indian Institute of Science

1. Sagurthi, Someswar Rao. Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium.

Degree: 2009, Indian Institute of Science

X-ray crystallography is one of the most powerful tools for the elucidation of the structure of biological macromolecules such as proteins and viruses. Crystallographic techniques are extensively used for investigations on protein structure, ligand-binding, mechanisms of enzyme catalyzed reactions, protein-protein interactions, role of metal ions in protein structure and function, structure of multi-enzyme complexes and viruses, protein dynamics and for a myriad other problems in structural biology. Crystallographic studies are essential for understanding the intricate details of the mechanism of action of enzymes at molecular level. Understanding the subtle differences between the pathogenic enzymes and host enzymes is necessary for the design of inhibitor molecules that specifically inhibit parasite enzymes. The current thesis deals with the application of biochemical and crystallographic techniques for understanding the structure and function of proteins from two pathogenic organisms – a plant virus Physalis Mottle Virus (PhMV), and a pathogenic bacterium, Salmonella typhimurium and also stress induced proteins from Oryza sativa. The thesis has been divided into seven chapters, with the first four chapters describing the work carried out on PhMV, while the rest of the chapters deal with the studies on stress response proteins from Oryza sativa and Salmonella typhimurium. The first part of the thesis deals with studies on viral capsids. Viruses are obligate parasites that have proteinaceous capsids enclosing the genetic material, which, in the case of small plant viruses, is invariably ss-RNA. X-ray diffraction studies on single crystals of viruses enable visualization of the structures of intact virus particles at near-atomic resolution. These studies provide detailed information regarding the coat protein folding, molecular interactions between protein subunits, flexibility of the N-and C-terminal segments and their probable importance in viral assembly, role of RNA in capsid assembly, nucleic acid (RNA)-protein interactions, the capsid structure and mechanism of assembly and disassembly. The present thesis deals with the capsid structure and analysis of the coat protein (CP) recombinant mutants of PhMV. Virus assembly, one of the important steps in the life cycle of a virus, involves specific interactions between the structural protein and cognate viral genome. This is a complex process that requires precise protein-protein and protein nucleic acid interactions. In fact, most of the biological functional units such as ribosomes and proteosomes also require highly co-ordinated macromolecular interactions for their functional expression. Viruses being simple in their architecture, serve as excellent model systems to understand mechanism of macromolecular assembly and provide necessary information for the development of antiviral therapeutics, especially in animal viruses. PhMV is a plant virus infecting several members of Solanaceae family. It belongs to the tymoviridae group of single stranded RNA viruses. Its… Advisors/Committee Members: Murthy, M R N.

Subjects/Keywords: Typhoiopoidea - Proteins; Typhoid Virus - Proteins; Physalis Mottle Virus Proteins; Oryza Sativa Virus - Proteins; Viral Capsids; Stress Response Proteins; Capsid Proteins; Salmonella typhimurium; Physalis Mottle Virus (PhMV); Virology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sagurthi, S. R. (2009). Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium. (Thesis). Indian Institute of Science. Retrieved from http://hdl.handle.net/2005/1974

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Sagurthi, Someswar Rao. “Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium.” 2009. Thesis, Indian Institute of Science. Accessed July 07, 2020. http://hdl.handle.net/2005/1974.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Sagurthi, Someswar Rao. “Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium.” 2009. Web. 07 Jul 2020.

Vancouver:

Sagurthi SR. Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium. [Internet] [Thesis]. Indian Institute of Science; 2009. [cited 2020 Jul 07]. Available from: http://hdl.handle.net/2005/1974.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sagurthi SR. Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium. [Thesis]. Indian Institute of Science; 2009. Available from: http://hdl.handle.net/2005/1974

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Indian Institute of Science

2. Sagurthi, Someswar Rao. Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium.

Degree: 2009, Indian Institute of Science

X-ray crystallography is one of the most powerful tools for the elucidation of the structure of biological macromolecules such as proteins and viruses. Crystallographic techniques are extensively used for investigations on protein structure, ligand-binding, mechanisms of enzyme catalyzed reactions, protein-protein interactions, role of metal ions in protein structure and function, structure of multi-enzyme complexes and viruses, protein dynamics and for a myriad other problems in structural biology. Crystallographic studies are essential for understanding the intricate details of the mechanism of action of enzymes at molecular level. Understanding the subtle differences between the pathogenic enzymes and host enzymes is necessary for the design of inhibitor molecules that specifically inhibit parasite enzymes. The current thesis deals with the application of biochemical and crystallographic techniques for understanding the structure and function of proteins from two pathogenic organisms – a plant virus Physalis Mottle Virus (PhMV), and a pathogenic bacterium, Salmonella typhimurium and also stress induced proteins from Oryza sativa. The thesis has been divided into seven chapters, with the first four chapters describing the work carried out on PhMV, while the rest of the chapters deal with the studies on stress response proteins from Oryza sativa and Salmonella typhimurium. The first part of the thesis deals with studies on viral capsids. Viruses are obligate parasites that have proteinaceous capsids enclosing the genetic material, which, in the case of small plant viruses, is invariably ss-RNA. X-ray diffraction studies on single crystals of viruses enable visualization of the structures of intact virus particles at near-atomic resolution. These studies provide detailed information regarding the coat protein folding, molecular interactions between protein subunits, flexibility of the N-and C-terminal segments and their probable importance in viral assembly, role of RNA in capsid assembly, nucleic acid (RNA)-protein interactions, the capsid structure and mechanism of assembly and disassembly. The present thesis deals with the capsid structure and analysis of the coat protein (CP) recombinant mutants of PhMV. Virus assembly, one of the important steps in the life cycle of a virus, involves specific interactions between the structural protein and cognate viral genome. This is a complex process that requires precise protein-protein and protein nucleic acid interactions. In fact, most of the biological functional units such as ribosomes and proteosomes also require highly co-ordinated macromolecular interactions for their functional expression. Viruses being simple in their architecture, serve as excellent model systems to understand mechanism of macromolecular assembly and provide necessary information for the development of antiviral therapeutics, especially in animal viruses. PhMV is a plant virus infecting several members of Solanaceae family. It belongs to the tymoviridae group of single stranded RNA viruses. Its… Advisors/Committee Members: Murthy, M R N.

Subjects/Keywords: Typhoiopoidea - Proteins; Typhoid Virus - Proteins; Physalis Mottle Virus Proteins; Oryza Sativa Virus - Proteins; Viral Capsids; Stress Response Proteins; Capsid Proteins; Salmonella typhimurium; Physalis Mottle Virus (PhMV); Virology

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sagurthi, S. R. (2009). Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium. (Thesis). Indian Institute of Science. Retrieved from http://etd.iisc.ernet.in/handle/2005/1974 ; http://etd.ncsi.iisc.ernet.in/abstracts/2559/G23450-Abs.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Sagurthi, Someswar Rao. “Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium.” 2009. Thesis, Indian Institute of Science. Accessed July 07, 2020. http://etd.iisc.ernet.in/handle/2005/1974 ; http://etd.ncsi.iisc.ernet.in/abstracts/2559/G23450-Abs.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Sagurthi, Someswar Rao. “Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium.” 2009. Web. 07 Jul 2020.

Vancouver:

Sagurthi SR. Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium. [Internet] [Thesis]. Indian Institute of Science; 2009. [cited 2020 Jul 07]. Available from: http://etd.iisc.ernet.in/handle/2005/1974 ; http://etd.ncsi.iisc.ernet.in/abstracts/2559/G23450-Abs.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sagurthi SR. Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium. [Thesis]. Indian Institute of Science; 2009. Available from: http://etd.iisc.ernet.in/handle/2005/1974 ; http://etd.ncsi.iisc.ernet.in/abstracts/2559/G23450-Abs.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.