subject:(Tumeurs c r brales p diatriques fluvastatine celecoxib drug repositioning astrocytome pilocytique profil mol culaire BRAF)

1. Mercurio, Sandy. Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors.

Degree: Docteur es, Biologie. Immunologie, 2013, Aix Marseille Université

URL: http://www.theses.fr/2013AIXM5094

► Les tumeurs gliales et glioneuronales sont les tumeurs cérébrales les plus fréquentes chez l'enfant. Elles sont généralement d'excellent pronostic. En revanche, les astrocytomes pilocytiques (AP)… (more)

▼ Les tumeurs gliales et glioneuronales sont les tumeurs cérébrales les plus fréquentes chez l'enfant. Elles sont généralement d'excellent pronostic. En revanche, les astrocytomes pilocytiques (AP) hypothalamo-chiasmatiques, ont un potentiel évolutif plus agressif. Ce travail de thèse propose une nouvelle stratégie thérapeutique pour ce sous-type d'AP selon la méthode du « drug repositioning », en employant la combinaison du celecoxib et de la fluvastatine. Nos travaux ont montré in vitro que cette association de molécules était synergique, capable d'arrêter le cycle cellulaire, de diminuer la prolifération et d'induire l'apoptose des cellules tumorales. Cette combinaison a également été testée avec succès chez une patiente souffrant d'un AP multifocal et réfractaire aux traitements conventionnels dans le cadre d'une thérapie métronomique. Ce manuscrit décrit également l'étude histo-moléculaire de plusieurs séries de tumeurs gliales et glioneuronales pédiatriques menées afin d'améliorer leur caractérisation et leur diagnostic. Nos travaux ont confirmé la présence de la fusion KIAA1549:BRAF dans les AP analysés ainsi que le caractère péjoratif de la topographie hypothalamo-chiasmatique, du variant histologique pilomyxoïde et de l'âge au diagnostic inférieur à 36 mois. Ils ont également montré l'absence de différence moléculaire entre les gliomes corticaux de grade II et des DNT. Enfin, nos travaux ont montré que les DNT, les GG et les PXA partagent la mutation BRAFV600E et l'expression de CD34. Ces travaux confirment l'implication majeure de l'altération de la voie des MAPKinases dans la tumorigenèse de ces tumeurs, constituant ainsi une cible thérapeutique prometteuse. p>Glial and glioneuronal tumors are the most frequent brain tumors in children. They are characterized by an excellent prognosis. However, hypothalamic-chiasmatic pilocytic astrocytomas (PA) have a more aggressive outcome. In the first part, we propose a new therapeutic strategy for hypothalamic-chiasmatic PA according to drug repositioning method, by using celecoxib, and fluvastatin. We showed that, in vitro, this combination was synergistic, stopped cell cycle, inhibited cell proliferation and increased apoptosis. In addition, this combination was tested with success, under a metronomic chemotherapy, for a girl suffering from a multifocal PA and refractory to conventional treatment. This new strategy of treatment appears promising for this type of tumor because it is less toxic than conventional chemotherapy and not too expensive. In the second part, this manuscript describes the histo-molecular study of several retrospective series of glial and glioneuronal pediatric tumors conducted to improve their characterization and their diagnosis. We confirmed the presence of the fusion gene KIAA1549: BRAF in PA as well as the pejorative nature of the hypothalamic-chiasmatic topography, pilomyxoïde histology and the age at diagnosis less than 36 months. We also showed no molecular difference between cortical grade II gliomas associated with chronic epilepsy…p> Advisors/Committee Members: Figarella-Branger, Dominique (thesis director).

Subjects/Keywords: Tumeurs cérébrales pédiatriques,fluvastatine/celecoxib,drug repositioning,astrocytome pilocytique,profil moléculaire,BRAF; Pediatric brain tumors,fluvastatin/celecoxib,drug repositioning,pilocytic astrocytoma,molecular profil,BRAF

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mercurio, S. (2013). Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2013AIXM5094

Chicago Manual of Style (16^th Edition):

Mercurio, Sandy. “Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors.” 2013. Doctoral Dissertation, Aix Marseille Université. Accessed March 03, 2021. http://www.theses.fr/2013AIXM5094.

MLA Handbook (7^th Edition):

Mercurio, Sandy. “Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors.” 2013. Web. 03 Mar 2021.

Vancouver:

Mercurio S. Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors. [Internet] [Doctoral dissertation]. Aix Marseille Université 2013. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2013AIXM5094.

Council of Science Editors:

Mercurio S. Mise en évidence de nouvelles cibles thérapeutiques dans les tumeurs gliales et glioneuronales de l'enfant : Evidence of new therapeutic targets in glial and glioneuronal pediatric tumors. [Doctoral Dissertation]. Aix Marseille Université 2013. Available from: http://www.theses.fr/2013AIXM5094

2. Padovani, Laëtitia. Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors.

Degree: Docteur es, Neurosciences, 2013, Aix Marseille Université

URL: http://www.theses.fr/2013AIXM5018

► La classification OMS des tumeurs cérébrales de l'enfant distingue les tumeurs gliales des tumeurs glioneuronales, les gliomes circonscrits des infiltrants. Elle représente le meilleur indicateur… (more)

Subjects/Keywords: Braf, tumeurs cérébrales pediatriques, profil moléculaire, dnt, tumeurs circonscrites, astocytome pilocytique, gangliogliome; Braf, pediatric brain tumors, molecular profil, DNT, low grade glioma, pilocytic astrocytoma, ganglioglioma

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APA (6^th Edition):

Padovani, L. (2013). Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2013AIXM5018

Chicago Manual of Style (16^th Edition):

Padovani, Laëtitia. “Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors.” 2013. Doctoral Dissertation, Aix Marseille Université. Accessed March 03, 2021. http://www.theses.fr/2013AIXM5018.

MLA Handbook (7^th Edition):

Padovani, Laëtitia. “Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors.” 2013. Web. 03 Mar 2021.

Vancouver:

Padovani L. Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors. [Internet] [Doctoral dissertation]. Aix Marseille Université 2013. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2013AIXM5018.

Council of Science Editors:

Padovani L. Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant : Molecular caracteristics of low grade pediatric brain tumors. [Doctoral Dissertation]. Aix Marseille Université 2013. Available from: http://www.theses.fr/2013AIXM5018

3. El Ayachi, Ikbale. KIAA 0510, Ténascine R, et astrocytomes pilocytiques : KIAA 0510, Tenascin R and pilocytic astrocytomas.

Degree: Docteur es, Neurosciences, 2010, Aix-Marseille 2

URL: http://www.theses.fr/2010AIX20684

► Les gliomes sont les tumeurs primitives les plus fréquentes du système nerveux central. Cette dernière décennie, l’apport de la biologie moléculaire a permis de mieux… (more)

▼ Les gliomes sont les tumeurs primitives les plus fréquentes du système nerveux central. Cette dernière décennie, l’apport de la biologie moléculaire a permis de mieux appréhender leurs comportements et de mieux préciser leur origine. Nous avons montré que le profil moléculaire des glioblastomes (grade IV dans la classification de l’OMS) et celui des astrocytomes pilocytiques (grade I dans la classification de l’OMS) différait notamment par l’expression d’un gène nommé KIAA 0510. La caractérisation de sa séquence nous a mené à nous intéresser à la Ténascine R, une glycoprotéine de la matrice extracellulaire impliquée dans les processus de migration et de différenciation cellulaire. Par ailleurs, l’expression de la Ténascine R pendant le développement, suggère son implication au cours de la corticogenèse.Dans le but de mieux comprendre l’origine des astrocytomes pilocytiques, notamment ceux de la région des voies optiques, nous avons mis en évidence au niveau du chiasma optique en développement des cellules de la glie radiaire à partir desquelles les astrocytomes pilocytiques des voies optiques pourraient dériver. p>Gliomas are the most frequently occurring primary tumors in the central nervous system. These last years, molecular biology technics allowed a better understanding of the gliomagenesis as well as behaviour of these tumors. We have previously shown that molecular profiling of glioblastomes (WHO grade IV) and pilocytic astrocytomas (WHO grade I) differed for KIAA 0510 gene expression. This sequence was fully characterized and shown to be part of the tenascin R gene encoding for an extracellular matrix glycoprotein involved in migration and cell differentiation. In addition, during development, Tenascin-R may be involved in corticogenesis.In parallel, in the developing optic chiasm, we evidenced cells with radial glial characteristics from which the hypothalamo-chiasmatic pilocytic astrocytomas could derive.p> Advisors/Committee Members: Figarella-Branger, Dominique (thesis director).

Subjects/Keywords: Kiaa 0510; Ténascine R; Astrocytome pilocytique; Matrice extracellulaire; Corticogenèse; Kiaa 0510; Tenascin R; Pilocytic astrocytomas; Extracellular matrix; Corticogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

El Ayachi, I. (2010). KIAA 0510, Ténascine R, et astrocytomes pilocytiques : KIAA 0510, Tenascin R and pilocytic astrocytomas. (Doctoral Dissertation). Aix-Marseille 2. Retrieved from http://www.theses.fr/2010AIX20684

Chicago Manual of Style (16^th Edition):

El Ayachi, Ikbale. “KIAA 0510, Ténascine R, et astrocytomes pilocytiques : KIAA 0510, Tenascin R and pilocytic astrocytomas.” 2010. Doctoral Dissertation, Aix-Marseille 2. Accessed March 03, 2021. http://www.theses.fr/2010AIX20684.

MLA Handbook (7^th Edition):

El Ayachi, Ikbale. “KIAA 0510, Ténascine R, et astrocytomes pilocytiques : KIAA 0510, Tenascin R and pilocytic astrocytomas.” 2010. Web. 03 Mar 2021.

Vancouver:

El Ayachi I. KIAA 0510, Ténascine R, et astrocytomes pilocytiques : KIAA 0510, Tenascin R and pilocytic astrocytomas. [Internet] [Doctoral dissertation]. Aix-Marseille 2; 2010. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2010AIX20684.

Council of Science Editors:

El Ayachi I. KIAA 0510, Ténascine R, et astrocytomes pilocytiques : KIAA 0510, Tenascin R and pilocytic astrocytomas. [Doctoral Dissertation]. Aix-Marseille 2; 2010. Available from: http://www.theses.fr/2010AIX20684

Georgia State University

4. Alosaimi, Samar. When to Initiate Pulmonary Rehabilitation Program for Chronic Obstructive Pulmonary Disease Patients.

Degree: MS, Respiratory Therapy, 2018, Georgia State University

URL: https://scholarworks.gsu.edu/rt_theses/43

► Pulmonary rehabilitation (PR) has a positive effect on COPD patients. The response to PR demonstrates positive impacts on daily life activities and exercise tolerance.… (more)

▼ Pulmonary rehabilitation (PR) has a positive effect on COPD patients. The response to PR demonstrates positive impacts on daily life activities and exercise tolerance. However, the referral criteria to PR program for COPD patients does not mention anything about the time factor or the stage of the disease. The recommended stage of starting the program should be included in the acceptance guidelines. More studies are needed to examine which COPD stage will benefit more than the others. PURPOSE: The purpose of the study is to determine the most optimal time to start pulmonary rehabilitation for COPD patients. METHOD: A retrospective study was utilized, and the data were collected from an urban hospital for the last five years (2013 to 2017). Patients were divided into four groups using the GOLD classification guideline for COPD patients. Every group represents different FEV₁ range and has pre- and post-PR program variables. The measured variables were 6MWT and Chronic Respiratory Questionnaire(CRQ). The evaluation focused on the comparison between the groups, not within the groups. DATA ANALYSIS: The analysis was conducted by SPSS version 24.0. Descriptive statistics, dependent sample t-test, ANOVA, and Welch test were utilized. T-test was used to find the difference between pre- and post-variables and ANOVA test to compare the difference between the four groups. RESULTS: comparison between groups ANOVA results were Six-minute walk difference F (3.65) =1.3, p=.281. Dyspnea difference F (3.65) =.155, p=.926. Fatigue difference F (3,65) =.640, p=.592. Emotional difference F (3,65) =.221, p=.881. Mastery difference F (3,65) =.363, p=.780. CONCLUSION: There was a significant difference between pre- and post-pulmonary rehabilitation results and all the groups responded positively to the program. There were no significantly different responses to the program between the four groups. As a result, there is no specific preferred stage to start the program. Advisors/Committee Members: Douglas Gardenhire, Chip Zimmerman, Shi Huh Samuel Shan.

Subjects/Keywords: P; R; C; O; P; D

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APA (6^th Edition):

Alosaimi, S. (2018). When to Initiate Pulmonary Rehabilitation Program for Chronic Obstructive Pulmonary Disease Patients. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/rt_theses/43

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alosaimi, Samar. “When to Initiate Pulmonary Rehabilitation Program for Chronic Obstructive Pulmonary Disease Patients.” 2018. Thesis, Georgia State University. Accessed March 03, 2021. https://scholarworks.gsu.edu/rt_theses/43.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alosaimi, Samar. “When to Initiate Pulmonary Rehabilitation Program for Chronic Obstructive Pulmonary Disease Patients.” 2018. Web. 03 Mar 2021.

Vancouver:

Alosaimi S. When to Initiate Pulmonary Rehabilitation Program for Chronic Obstructive Pulmonary Disease Patients. [Internet] [Thesis]. Georgia State University; 2018. [cited 2021 Mar 03]. Available from: https://scholarworks.gsu.edu/rt_theses/43.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alosaimi S. When to Initiate Pulmonary Rehabilitation Program for Chronic Obstructive Pulmonary Disease Patients. [Thesis]. Georgia State University; 2018. Available from: https://scholarworks.gsu.edu/rt_theses/43

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

5. Modak, Swananda Rajan. Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease.

Degree: 2013, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:212548

► Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease.Swananda R. Modak, Andrew J. Doig and Paul F.G.… (more)

▼ Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease.Swananda R. Modak, Andrew J. Doig and Paul F.G. Sims.Manchester Institute of Biotechnology, Faculty of Life Sciences, The University of Manchester, UK.The neuropathological process in Alzheimer’s disease (AD) is characterized by both intra and extracellular Aβ42 aggregates. The neuropathological process of AD is complex and the exact cause of Aβ aggregation leading towards neuronal death is yet unknown. Several events are implicated towards the development of AD including changes within the proteome. With more than 30 million people currently affected with AD, there is still no cure for AD. In this project we seek to identify differential protein profiles by undertaking a comparative analysis of the intracellular and extracellular effects of Aβ on the human proteome using two cellular neuronal models: MC65 and SHSY5Y cells, to understand the biochemical pathology underlying AD. We also initiated a compound screening approach which not only identified several small molecules and peptides inhibiting the Aβ cytotoxicity, but also identified several known compounds from the LOPAC library acting as potential inhibitors of intra and extracellular Aβ42 cytotoxicity, thus highlighting the importance of drug repositioning to identify novel compounds in the therapeutic regime of AD which could be categorized as Aβ toxicity inhibitors. A comparative qualitative proteomics approach was undertaken using OFFGEL fractionation. The MS data was analysed through GO, biological pathway and protein interaction analysis using various databases such as UniProtKB, DAVID v6.7, KEGG and String 9.0 for the SHSY5Y cells treated with extracellular Aβ42 and MC65 cells which conditionally express intracellular C99, that is further cleaved to intracellular Aβ. This was followed by validation of 8 proteins by in-cell Western assay (ICW) undertaken using the LI-COR Infrared Imaging System for the cell lysates of control and Aβ42 treated SH-SY5Y as well as Aβ induced MC65 cells. We have also screened a library of 1280 LOPAC compounds on both the cell lines and 9 other compounds previously known as Aβ toxicity inhibitors on MC65 cells. The lead compounds were further characterized using MTT, LDH, ThT and ICW assays.The proteomics methodology undertaken through this project identified several novel proteins specific to intracellular and extracellular Aβ aggregation. The GO, biological pathway analysis and the functional interaction study helped to identify proteins associated from the proteasome pathway to be affected as an effect of Aβ aggregation for both the cells exposed with intra and extracellular Aβ aggregation. The compound screening study also identified several compounds as inhibitors of Aβ cytotoxicity. A-77636, a D1 dopamine receptor agonist was identified as a lead compound to reduce the extracellular Aβ42 cytotoxicity at nM concentration. Moreover, 1,3-Diethyl-8-phenylxanthine and Arecaidine propargyl ester hydrobromide also… Advisors/Committee Members: SIMS, PAUL PFG, Sims, Paul, Doig, Andrew.

Subjects/Keywords: Alzheimer's disease; Drug repositioning; Proteomics

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APA (6^th Edition):

Modak, S. R. (2013). Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:212548

Chicago Manual of Style (16^th Edition):

Modak, Swananda Rajan. “Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease.” 2013. Doctoral Dissertation, University of Manchester. Accessed March 03, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:212548.

MLA Handbook (7^th Edition):

Modak, Swananda Rajan. “Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease.” 2013. Web. 03 Mar 2021.

Vancouver:

Modak SR. Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Mar 03]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:212548.

Council of Science Editors:

Modak SR. Effects of Aβ42 on the Human Proteome and Compound Library Screening using Cellular Models of Alzheimer’s Disease. [Doctoral Dissertation]. University of Manchester; 2013. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:212548

Harvard University

6. Brown, Adam Samuel. Expanding the Computational Drug Repositioning Toolbox.

Degree: PhD, 2017, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061514

► Repositioning of previously approved drugs is a promising methodology because it lowers the cost and duration of the drug development pipeline and reduces the likelihood… (more)

▼ Repositioning of previously approved drugs is a promising methodology because it lowers the cost and duration of the drug development pipeline and reduces the likelihood of unforeseen adverse events. Computational repositioning is especially appealing due to the ability to rapidly and scalably screen candidates in silico. However, despite increasing interest in repositioning from both academia and industry, existing computational methods are limited in their generalizability and reproducibility. We hypothesize that by expanding the scope of data accessible for repositioning, while at the same time improving the quality of analytic validation for new methods, repositioning studies can make higher quality predictions of promising repositioning candidates. Here we describe three methods that expand the types of data that can be leveraged for computational repositioning: (1) ksRepo, which expands the scope of gene-based repositioning and allows for the use of any ‘omics modality for disease profiling, (2) MeSHDD, for which we developed a novel drug-drug similarity metric based on overlap between drugs and medical subject heading (MeSH) terms in the biomedical literature, and (3) a novel method for quantitative trait-based repositioning using deep cross-sectional phenotyping studies that explicitly addresses sources of confounding. We also describe our work to survey and improve reproducibility in the repositioning field, and introduce a new standard database, repoDB, that contains over 10,000 drug-disease pairs, including examples of both approved and failed pairs. Together, the methods and resources described here represent an expansion of the computational drug repositioning toolbox, as well as a first step towards enabling reproducible validation of drug repositioning methods. p>Medical Sciencesp> Advisors/Committee Members: Raychaudhuri, Soumya (advisor), Gehlenborg, Nils (committee member), Avillach, Paul (committee member), Kasif, Simon (committee member).

Subjects/Keywords: Drug Repositioning; Drug Discovery; Bioinformatics; Gene Expression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brown, A. S. (2017). Expanding the Computational Drug Repositioning Toolbox. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061514

Chicago Manual of Style (16^th Edition):

Brown, Adam Samuel. “Expanding the Computational Drug Repositioning Toolbox.” 2017. Doctoral Dissertation, Harvard University. Accessed March 03, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061514.

MLA Handbook (7^th Edition):

Brown, Adam Samuel. “Expanding the Computational Drug Repositioning Toolbox.” 2017. Web. 03 Mar 2021.

Vancouver:

Brown AS. Expanding the Computational Drug Repositioning Toolbox. [Internet] [Doctoral dissertation]. Harvard University; 2017. [cited 2021 Mar 03]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061514.

Council of Science Editors:

Brown AS. Expanding the Computational Drug Repositioning Toolbox. [Doctoral Dissertation]. Harvard University; 2017. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061514

University of Southern California

7. Yardley, Megan M. Development of ivermectin as a platform for the treatment and/or prevention of alcohol use disorders.

Degree: PhD, Molecular Pharmacology and Toxicology, 2016, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/444768/rec/1949

► Alcohol use disorders (AUDs) affect over 18 million people in the United States alone, cost over $235 billion, and yet only 8% of this population… (more)

▼ Alcohol use disorders (AUDs) affect over 18 million people in the United States alone, cost over $235 billion, and yet only 8% of this population receives treatment and even less use a medication approved by the U.S. Food and Drug Administration (FDA) as part of that treatment. Despite considerable efforts focusing on new drug development to reduce ethanol abuse, high rates of harmful drinking persist. This is, in part, due to the fact that current therapeutic strategies are largely inadequate to treat these disorders. Thus, developing novel therapeutics for the treatment of AUDs is of paramount importance. The working hypothesis of our laboratory is that ivermectin (IVM) can be repurposed as a therapeutic agent for the treatment of AUDs. As IVM is currently FDA‐approved and used by millions of humans each year for other indications, the repurposing of IVM for the treatment of AUDs represents a fast and economically feasible approach for drug development. Initial support suggesting that IVM can be developed as a novel drug candidate for the treatment of AUDs comes from previous work demonstrating that IVM is able to antagonize the effect of ethanol in vitro on P2X4 receptors (PRX4Rs). Studies included in this dissertation test the hypothesis that IVM can be repurposed as a therapeutic agent for the treatment of AUDs using multiple preclinical mouse models of ethanol intake and behavior. Chapter 2 describes initial efficacy studies using 3 distinct models of ethanol intake and explores the pharmacokinetics (PK) of IVM. Chapter 3 characterizes the intrinsic properties of IVM using a battery of behavioral paradigms to test for effects such as depression, anxiety, locomotion, memory, and rewarding properties. Chapter 4 evaluates the sustainability and safety of multi‐day IVM administration. Finally, Chapter 5 focuses on the use of IVM as a platform for developing novel therapeutics for AUDs by testing two related avermectins, selamectin (SEL) and abamectin (ABM). Findings from my work support the hypothesis that IVM is able to reduce ethanol intake using multiple murine models of ethanol intake without causing overt toxicity. Overall, the studies presented within this dissertation set the stage for first-in-human testing of IVM for this new indication. Advisors/Committee Members: Cadenas, EnriqueDavies, Daryl L. (Committee Chair), Richmond, Frances J. (Committee Member), Neely, Michael J. (Committee Member).

Subjects/Keywords: medications development; alcoholism therapy; drug repositioning

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APA (6^th Edition):

Yardley, M. M. (2016). Development of ivermectin as a platform for the treatment and/or prevention of alcohol use disorders. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/444768/rec/1949

Chicago Manual of Style (16^th Edition):

Yardley, Megan M. “Development of ivermectin as a platform for the treatment and/or prevention of alcohol use disorders.” 2016. Doctoral Dissertation, University of Southern California. Accessed March 03, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/444768/rec/1949.

MLA Handbook (7^th Edition):

Yardley, Megan M. “Development of ivermectin as a platform for the treatment and/or prevention of alcohol use disorders.” 2016. Web. 03 Mar 2021.

Vancouver:

Yardley MM. Development of ivermectin as a platform for the treatment and/or prevention of alcohol use disorders. [Internet] [Doctoral dissertation]. University of Southern California; 2016. [cited 2021 Mar 03]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/444768/rec/1949.

Council of Science Editors:

Yardley MM. Development of ivermectin as a platform for the treatment and/or prevention of alcohol use disorders. [Doctoral Dissertation]. University of Southern California; 2016. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/444768/rec/1949

University of Sydney

8. Keung, Karen Lok Yee. The Application of Transcriptomics in Kidney Transplant Injury .

Degree: 2019, University of Sydney

URL: http://hdl.handle.net/2123/21050

► This research aimed to address two unmet clinical needs in renal transplantation. Firstly, novel therapeutics to improve allograft outcomes are required. Secondly, non-invasive prognostic biomarkers… (more)

▼ This research aimed to address two unmet clinical needs in renal transplantation. Firstly, novel therapeutics to improve allograft outcomes are required. Secondly, non-invasive prognostic biomarkers to predict adverse allograft outcomes are needed to provide an early treatment opportunity. The use of large-scale molecular profiling data coupled with advanced computational strategies to address these needs was the foundation for this research. In chapters 3 and 4, the aim was to describe for the first time the derivation of master regulatory genes, or key drivers, amongst the pathologic molecular pathways in acute rejection (AR) of the renal allograft, and demonstrate that these may serve as novel targets for therapeutic intervention. Using microarray gene expression datasets from human renal allograft biopsy tissue, an integrative network-based computational approach was employed to predict the key driver genes in AR, identifying 14 key drivers. Interrogation of a computational drug-repositioning resource identified drugs in current clinical use as candidates for repositioning in AR prevention. Minocycline was selected for validation in a murine cardiac allograft model of AR. Used alone, it attenuated the inflammatory profile of AR compared with controls, and prolonged graft survival when co-administered with immunosuppression. The aim of the work in chapter 5 was to facilitate the discovery of a whole blood, thus non-invasive, prognostic biomarker signature obtained early in the post-transplant course that could predict patients who will develop allograft fibrosis. Early identification of these patients could provide an opportunity to alter immunosuppression before fibrosis is established. Here, validation of an unpublished prognostic microRNA signature derived from whole blood obtained 3 months post-transplant, to predict those with allograft fibrosis 12 months post-transplant, was sought. This signature was derived from collaborators in the Genomics of Chronic Allograft Dysfunction (GoCAR) study, and validation sought using samples from the Australian Chronic Allograft Dysfunction (AUSCAD) study, a single-centre cohort of transplant patients with prospective collection of renal biopsy and biofluid samples with linked clinical data. The 4-miRNA signature was unable to accurately prognosticate patients that progressed to fibrosis at 12 months in the AUSCAD cohort. How future work could be modified to facilitate the identification and validation of a robust prognostic biomarker signature are addressed.

Subjects/Keywords: Kidney; Transplantation; acute rejection; transcriptomics; drug repositioning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keung, K. L. Y. (2019). The Application of Transcriptomics in Kidney Transplant Injury . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/21050

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Keung, Karen Lok Yee. “The Application of Transcriptomics in Kidney Transplant Injury .” 2019. Thesis, University of Sydney. Accessed March 03, 2021. http://hdl.handle.net/2123/21050.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Keung, Karen Lok Yee. “The Application of Transcriptomics in Kidney Transplant Injury .” 2019. Web. 03 Mar 2021.

Vancouver:

Keung KLY. The Application of Transcriptomics in Kidney Transplant Injury . [Internet] [Thesis]. University of Sydney; 2019. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2123/21050.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Keung KLY. The Application of Transcriptomics in Kidney Transplant Injury . [Thesis]. University of Sydney; 2019. Available from: http://hdl.handle.net/2123/21050

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

9. Modak, Swananda Rajan. Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease.

Degree: PhD, 2013, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/effects-of-a42-on-the-human-proteome-and-compound-library-screening-using-cellular-models-of-alzheimers-disease(4cca38b1-fd3f-4ef1-bde1-e16cf227ef68).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764270

► The neuropathological process in Alzheimer's disease (AD) is characterized by both intra and extracellular Aβ42 aggregates. The neuropathological process of AD is complex and the… (more)

▼ The neuropathological process in Alzheimer's disease (AD) is characterized by both intra and extracellular Aβ42 aggregates. The neuropathological process of AD is complex and the exact cause of Aβ aggregation leading towards neuronal death is yet unknown. Several events are implicated towards the development of AD including changes within the proteome. With more than 30 million people currently affected with AD, there is still no cure for AD. In this project we seek to identify differential protein profiles by undertaking a comparative analysis of the intracellular and extracellular effects of Aβ on the human proteome using two cellular neuronal models: MC65 and SHSY5Y cells, to understand the biochemical pathology underlying AD. We also initiated a compound screening approach which not only identified several small molecules and peptides inhibiting the Aβ cytotoxicity, but also identified several known compounds from the LOPAC library acting as potential inhibitors of intra and extracellular Aβ42 cytotoxicity, thus highlighting the importance of drug repositioning to identify novel compounds in the therapeutic regime of AD which could be categorized as Aβ toxicity inhibitors. A comparative qualitative proteomics approach was undertaken using OFFGEL fractionation. The MS data was analysed through GO, biological pathway and protein interaction analysis using various databases such as UniProtKB, DAVID v6.7, KEGG and String 9.0 for the SHSY5Y cells treated with extracellular Aβ42 and MC65 cells which conditionally express intracellular C99, that is further cleaved to intracellular Aβ. This was followed by validation of 8 proteins by in-cell Western assay (ICW) undertaken using the LI-COR Infrared Imaging System for the cell lysates of control and Aβ42 treated SH-SY5Y as well as Aβ induced MC65 cells. We have also screened a library of 1280 LOPAC compounds on both the cell lines and 9 other compounds previously known as Aβ toxicity inhibitors on MC65 cells. The lead compounds were further characterized using MTT, LDH, ThT and ICW assays. The proteomics methodology undertaken through this project identified several novel proteins specific to intracellular and extracellular Aβ aggregation. The GO, biological pathway analysis and the functional interaction study helped to identify proteins associated from the proteasome pathway to be affected as an effect of Aβ aggregation for both the cells exposed with intra and extracellular Aβ aggregation. The compound screening study also identified several compounds as inhibitors of Aβ cytotoxicity. A-77636, a D1 dopamine receptor agonist was identified as a lead compound to reduce the extracellular Aβ42 cytotoxicity at nM concentration. Moreover, 1,3-Diethyl-8-phenylxanthine and Arecaidine propargyl ester hydrobromide also proved successful in attenuating the extracellular Aβ42 cytotoxicity. Apart from this; SEN1000, SEN304 and Scylloinositol were able to completely attenuate the intracellular Aβ cytotoxicity, whereas two other compounds, 1,3-Dipropyl-8-p-sulfophenylxanthine and…

Subjects/Keywords: 616.8; Drug repositioning; Proteomics; Alzheimer's disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Modak, S. R. (2013). Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/effects-of-a42-on-the-human-proteome-and-compound-library-screening-using-cellular-models-of-alzheimers-disease(4cca38b1-fd3f-4ef1-bde1-e16cf227ef68).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764270

Chicago Manual of Style (16^th Edition):

Modak, Swananda Rajan. “Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease.” 2013. Doctoral Dissertation, University of Manchester. Accessed March 03, 2021. https://www.research.manchester.ac.uk/portal/en/theses/effects-of-a42-on-the-human-proteome-and-compound-library-screening-using-cellular-models-of-alzheimers-disease(4cca38b1-fd3f-4ef1-bde1-e16cf227ef68).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764270.

MLA Handbook (7^th Edition):

Modak, Swananda Rajan. “Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease.” 2013. Web. 03 Mar 2021.

Vancouver:

Modak SR. Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Mar 03]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/effects-of-a42-on-the-human-proteome-and-compound-library-screening-using-cellular-models-of-alzheimers-disease(4cca38b1-fd3f-4ef1-bde1-e16cf227ef68).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764270.

Council of Science Editors:

Modak SR. Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/effects-of-a42-on-the-human-proteome-and-compound-library-screening-using-cellular-models-of-alzheimers-disease(4cca38b1-fd3f-4ef1-bde1-e16cf227ef68).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764270

10. Stabile, Angelo Clodomiro. Efeito do acetaminofeno e do celecoxib na distalização de incisivos e na ativação de regiões cerebrais relacionadas à nocicepção durante a movimentação ortodôntica em ratos.

Degree: Mestrado, Biologia Oral, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/58/58137/tde-29102008-173257/ ;

► Antiinflamatórios podem diminuir a movimentação dentária (MD) em pacientes ortodônticos, fato este que leva à existência de poucas alternativas terapêuticas para o tratamento da dor.… (more)

▼ Antiinflamatórios podem diminuir a movimentação dentária (MD) em pacientes ortodônticos, fato este que leva à existência de poucas alternativas terapêuticas para o tratamento da dor. Acetaminofeno tem sido a medicação de escolha, mas não é tolerado por alguns pacientes. Este trabalho pesquisou a influência do celecoxib e do acetaminofeno na separação ortodôntica dos incisivos centrais superiores de ratos, assim como na ativação de estruturas relacionadas à nocicepção no núcleo espinhal do trigêmio, por meio da expressão de c-fos nos subnúcleos caudalis, interpolaris e oralis. Num primeiro momento, o peso do animal e a força ortodôntica foram variados, quando foi possível encontrar o relacionamento ideal entre estas duas variáveis, o qual permitiu movimentação dentária sem expansão da sutura palatina mediana. A aplicação de 35 g de força em animais de 400 g de peso distalizou os incisivos sem expandir a sutura palatina mediana, como pôde ser verificado em radiografias da maxila dos animais. Sendo assim, trinta ratos Wistar, machos, pesando cerca de 400 g, foram pré-tratados através de sonda gástrica (1 ml) com acetaminofeno (80mg/ml), celecoxib (20mg/ml) ou veículo (carboximetilcelulose 0,4%). Após 30 minutos, foram submetidos à movimentação dentária (35 g de força) ou deixados como controles. Ração moída foi fornecida e a cada 12 horas eles receberam, na mesma dosagem anterior, um dos medicamentos ou veículo. Depois de 48 horas, foram novamente anestesiados, fotografados e perfundidos com paraformaldeído 4%. Na seqüência, a maxilla foi radiografada e os cérebros removidos e processados para a imunohistoquímica para c-fos. A movimentação dentária induziu a distalização dos incisivos (p< 0.05), mas a distância inter-incisal não foi modificada pelos medicamentos. Adicionalmente, a movimentação dentária e o tratamento com as drogas não causaram qualquer alteração no número de neurônios Fos positivos nos subnúcleos interpolaris e oralis. No subnúcleo caudalis, entretanto, as duas drogas reduziram o número de neurônios Fos positivos devidos ao estímulo ortodôntico (p<0,05). Concluímos que os dois medicamentos reduzem a ativação neuronal de região nociceptiva e não afetam a movimentação dentária, sendo que o celecoxib seria uma possível alternativa ao acetaminofeno para o alívio de dor em pacientes ortodônticos, nos casos em que este for contra indicado. p>Anti-inflammatory drugs may slow dental movement in orthodontic patients, which leads to low therapeutic alternatives for pain control. Acetaminophen has been the first choice medication for the majority of patients, but it is not well tolerate for some. This work evaluated the influence of celecoxib and acetaminophen in the orthodontic separation of superior central incisor of rats, such as in the activation of nociceptive related structures in the spinal trigeminal nucleus, using c-fos expression in caudalis, interpolaris, and oralis sub nuclei. In a first moment, animal weigh and orthodontic force were varied, when it was possible to find the ideal relationship…p> Advisors/Committee Members: Rocha, Maria Jose Alves da.

Subjects/Keywords: acetaminofeno; acetaminophen; c-fos; c-fos; celecoxib; celecoxib; movimentação ortodôntica; nocicepção; nociception; orthondontic movement; ratos; rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stabile, A. C. (2008). Efeito do acetaminofeno e do celecoxib na distalização de incisivos e na ativação de regiões cerebrais relacionadas à nocicepção durante a movimentação ortodôntica em ratos. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58137/tde-29102008-173257/ ;

Chicago Manual of Style (16^th Edition):

Stabile, Angelo Clodomiro. “Efeito do acetaminofeno e do celecoxib na distalização de incisivos e na ativação de regiões cerebrais relacionadas à nocicepção durante a movimentação ortodôntica em ratos.” 2008. Masters Thesis, University of São Paulo. Accessed March 03, 2021. http://www.teses.usp.br/teses/disponiveis/58/58137/tde-29102008-173257/ ;.

MLA Handbook (7^th Edition):

Stabile, Angelo Clodomiro. “Efeito do acetaminofeno e do celecoxib na distalização de incisivos e na ativação de regiões cerebrais relacionadas à nocicepção durante a movimentação ortodôntica em ratos.” 2008. Web. 03 Mar 2021.

Vancouver:

Stabile AC. Efeito do acetaminofeno e do celecoxib na distalização de incisivos e na ativação de regiões cerebrais relacionadas à nocicepção durante a movimentação ortodôntica em ratos. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Mar 03]. Available from: http://www.teses.usp.br/teses/disponiveis/58/58137/tde-29102008-173257/ ;.

Council of Science Editors:

Stabile AC. Efeito do acetaminofeno e do celecoxib na distalização de incisivos e na ativação de regiões cerebrais relacionadas à nocicepção durante a movimentação ortodôntica em ratos. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/58/58137/tde-29102008-173257/ ;

11. Gouffé, Valérie. L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach.

Degree: Docteur es, Sciences de gestion, 2013, Pau

URL: http://www.theses.fr/2013PAUU2013

► Avec les récentes réformes, dont la loi Hôpital, Patient, Santé et Territoires (HPST) de Juin 2009, l’hôpital s’est transformé non seulement dans sa forme organisationnelle… (more)

▼ Avec les récentes réformes, dont la loi Hôpital, Patient, Santé et Territoires (HPST) de Juin 2009, l’hôpital s’est transformé non seulement dans sa forme organisationnelle par la mise en oeuvre des pôles mais aussi dans son rapport à son environnement. Cette organisation polaire vise à rechercher une performance par une approche médico-économique. Ainsi les dispositifs de gestion ont été mis en place et cherchent à rendre compte de cette performance. Dans ce contexte, comment peuvent travailler des professionnels de champs aussi différents que celui de la gestion et celui du soin ? La gestion sous-entend une optimisation des moyens, alors que le service public défend en priorité des valeurs d’utilité sociale et d’attention aux usagers. Les acteurs du soin ont une forte identification professionnelle à cette mission d’utilité sociale. Dans ce travail, nous proposons d’identifier en quoi les décalages culturels au sein des pôles hospitaliers, participent à une perte de sens et de reconnaissance des agents à leur travail. Ces écarts culturels seront appréciés plus précisément au travers de l’appropriation des outils de gestion. Cette étude se base sur des entretiens réalisés au sein de différents hôpitaux (CHU et CH) et de secteur Médecine, Chirurgie, Obstétrique (MCO) et psychiatrie. Elle révèle lanécessité de pratiques managériales innovantes tournées notamment vers la gestion interculturelle afin que chaque acteur de ces nouvelles structures hospitalières se sente compris et intégré dans cette dynamique. L’étude proposée peut constituer un retour d’expérience intéressant pour mieux comprendre et améliorer l’utilisation des nouveaux outils de gestion. Des préconisations sont proposées et peuvent constituer des pistes de réflexion afin de répondre aux défis actuels de l’hôpital public. p>With the latest reforms, among which the Hospital, Patient, Healthcare and Territory (HPST) Law, the French Hospital has changed not only the form of its organisation through the implementation of a polar organisation, but also its environmental concern. This polar organisation aims to strive for performance and efficiency via an managerial and medical approach. Thus, some management tools have been set up aimed in particular at giving feedback on such performance. In this context, how can professionals from such distinct fields as management and healthcare work? Management implies the optimization of resources when the public sector above all upholds values of social usefulness and patient care. Healthcare actors feel very much involved in this mission of social usefulness. In this work we propose to identify how cultural gaps within hospital poles contribute to a loss of meaning and acknowledgment among healthcare agents. Those cultural gaps will be examined more particularly through management tool appropriation. This study relies on interviews conducted in various healthcare facilities (PCO and psychiatric hospitals of various capacities such as CHU and CH). It reveals the need for innovative managerial practices, especially…p> Advisors/Committee Members: Cargnello-Charles, Emmanuelle (thesis director).

Subjects/Keywords: Performance; Appropriation; Gestion; Interculturalité; P e r f o rma n c e; A p p r o p r i a t i o n ,; Ma n a g e me n t; I n t e r c u l t u r a l i sm

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APA (6^th Edition):

Gouffé, V. (2013). L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach. (Doctoral Dissertation). Pau. Retrieved from http://www.theses.fr/2013PAUU2013

Chicago Manual of Style (16^th Edition):

Gouffé, Valérie. “L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach.” 2013. Doctoral Dissertation, Pau. Accessed March 03, 2021. http://www.theses.fr/2013PAUU2013.

MLA Handbook (7^th Edition):

Gouffé, Valérie. “L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach.” 2013. Web. 03 Mar 2021.

Vancouver:

Gouffé V. L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach. [Internet] [Doctoral dissertation]. Pau; 2013. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2013PAUU2013.

Council of Science Editors:

Gouffé V. L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach. [Doctoral Dissertation]. Pau; 2013. Available from: http://www.theses.fr/2013PAUU2013

University of Cambridge

12. Croset, Samuel. Drug repositioning and indication discovery using description logics.

Degree: PhD, 2014, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/246260https://www.repository.cam.ac.uk/bitstream/1810/246260/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/3/thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/4/thesis.pdf.jpg

► Drug repositioning is the discovery of new indications for approved or failed drugs. This practice is commonly done within the drug discovery process in order… (more)

▼ Drug repositioning is the discovery of new indications for approved or failed drugs. This practice is commonly done within the drug discovery process in order to adjust or expand the application line of an active molecule. Nowadays, an increasing number of computational methodologies aim at predicting repositioning opportunities in an automated fashion. Some approaches rely on the direct physical interaction between molecules and protein targets (docking) and some methods consider more abstract descriptors, such as a gene expression signature, in order to characterise the potential pharmacological action of a drug (Chapter 1). On a fundamental level, repositioning opportunities exist because drugs perturb multiple biological entities, (on and off-targets) themselves involved in multiple biological processes. Therefore, a drug can play multiple roles or exhibit various mode of actions responsible for its pharmacology. The work done for my thesis aims at characterising these various modes and mechanisms of action for approved drugs, using a mathematical framework called description logics. In this regard, I first specify how living organisms can be compared to complex black box machines and how this analogy can help to capture biomedical knowledge using description logics (Chapter 2). Secondly, the theory is implemented in the Functional Therapeutic Chemical Classification System (FTC - https://www.ebi.ac.uk/chembl/ftc/), a resource defining over 20,000 new categories representing the modes and mechanisms of action of approved drugs. The FTC also indexes over 1,000 approved drugs, which have been classified into the mode of action categories using automated reasoning. The FTC is evaluated against a gold standard, the Anatomical Therapeutic Chemical Classification System (ATC), in order to characterise its quality and content (Chapter 3). Finally, from the information available in the FTC, a series of drug repositioning hypotheses were generated and made publicly available via a web application (https://www.ebi.ac.uk/chembl/research/ftc-hypotheses). A subset of the hypotheses related to the cardiovascular hypertension as well as for Alzheimer’s disease are further discussed in more details, as an example of an application (Chapter 4). The work performed illustrates how new valuable biomedical knowledge can be automatically generated by integrating and leveraging the content of publicly available resources using description logics and automated reasoning. The newly created classification (FTC) is a first attempt to formally and systematically characterise the function or role of approved drugs using the concept of mode of action. The open hypotheses derived from the resource are available to the community to analyse and design further experiments.

Subjects/Keywords: Ontology; Drug repositioning; Automated reasoning; RDF; Semantic Web; Drug discovery; OWL

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Croset, S. (2014). Drug repositioning and indication discovery using description logics. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/246260https://www.repository.cam.ac.uk/bitstream/1810/246260/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/3/thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/4/thesis.pdf.jpg

Chicago Manual of Style (16^th Edition):

Croset, Samuel. “Drug repositioning and indication discovery using description logics.” 2014. Doctoral Dissertation, University of Cambridge. Accessed March 03, 2021. https://www.repository.cam.ac.uk/handle/1810/246260https://www.repository.cam.ac.uk/bitstream/1810/246260/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/3/thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/4/thesis.pdf.jpg.

MLA Handbook (7^th Edition):

Croset, Samuel. “Drug repositioning and indication discovery using description logics.” 2014. Web. 03 Mar 2021.

Vancouver:

Croset S. Drug repositioning and indication discovery using description logics. [Internet] [Doctoral dissertation]. University of Cambridge; 2014. [cited 2021 Mar 03]. Available from: https://www.repository.cam.ac.uk/handle/1810/246260https://www.repository.cam.ac.uk/bitstream/1810/246260/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/3/thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/4/thesis.pdf.jpg.

Council of Science Editors:

Croset S. Drug repositioning and indication discovery using description logics. [Doctoral Dissertation]. University of Cambridge; 2014. Available from: https://www.repository.cam.ac.uk/handle/1810/246260https://www.repository.cam.ac.uk/bitstream/1810/246260/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/3/thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/246260/4/thesis.pdf.jpg

13. Nađpal Jelena. Fitohemijski skrining i biološka aktivnost ekstrakata i tradicionalnih proizvoda od plodova divljih ruža (Rosa L.;Rosaceae).

Degree: 2017, University of Novi Sad

URL: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija14920720204088.pdf?controlNumber=(BISIS)104437&fileName=14920720204088.pdf&id=7373&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=104437&source=OATD&language=en

► Cilj ove doktorske disertacije predstavljalo je ispitivanje fitohemijskog sastava i biološke aktivnosti vodenih i metanolnih ekstrakata svežih i suvih plodova, kao i voćne… (more)

▼ Cilj ove doktorske disertacije predstavljalo je ispitivanje fitohemijskog sastava i biološke aktivnosti vodenih i metanolnih ekstrakata svežih i suvih plodova, kao i voćne kaše i džema pripremljenih po tradicionalnoj recepturi od plodova šest samoniklih vrsta Rosa L.: R. canina, R. dumalis, R. dumetorum, R. tomentosa, R. arvensis, R. sempervirens. Ispitivanje fitohemijskog sastava obuhvatalo je LC -MS/MS analizu 64 odabrana fenolna jedinjenja, hinske kiseline (organske kiseline) kao i tri triterpenoida. Takođe, izvršeno je spektrofotometrijsko određivanje sadržaja ukupnih fenolnih i flavonoidnih jedinjenja, kao i vitamina C. Evaluacija biološke aktivnosti obuhvatala je in vitro ispitivanja antioksidantne i antiinflamatorne aktivnosti, kao i ispitivanje uticaja ekstrakata odabranih vrsta Rosa na aktivnost enzima acetilholinesteraze i rast tumorskih i netumorskih ćelija. Sumiranjem dobijenih rezultata može se zaključiti da sveži i suvi plodovi ispitivanih vrsta Rosa, kao i voćne kaše i džemovi predstavljaju značajan izvor vitamina C i fenolnih jedinjenja, sa elagnom kiselinom kao najzastupljenijom fenolnom komponentom. Takođe u pojedinim ekstraktima vrsta R. dumetorum i R. tomentosa detektovana je visoka koncentracija ursolne kiseline, dok je hinska kiselina prisutna u značajnoj koncentraciji u svim ispitivanim ekstraktima. Ekstrakti ispitivanih vrsta, izuzev vrste Rosa arvensis, pokazali su visok antioksidantni potencijal koji se ogleda u njihovoj sposobnosti neutralizacije nekoliko radikalskih vrsta, redukcionom potencijalu i sposobnosti inhibicije lipidne peroksidacije. Ispitivani ekstrakti ispoljili su umerenu antiinflamatornu aktivnost u pogledu inhibicije produkcije odabranih metabolita ciklooksigenaznog (12-HHT, TXB₂, PGE₂) i 12-lipooksigenaznog (12-HETE) metaboličkog puta arahidonske kiseline, posebno prostaglandina E . Takođe, in vitro ispitivanjem uticaja ekstrakata odabranih vrsta Rosa na aktivnost acetilholinesteraze pokazana je umerena aktivnost. Vodeni ekstrakti i ekstrakti voćnih kaša vrsta R. canina, R. tomentosa i R. sempervirens pokazali su umereni inhibitorni potencijal prema rastu HeLa ćelijske linije, dok su ekstrakti vrste R. sempervirens pokazali aktivnost i prema HT-29 ćelijama. Dobijeni rezultati ukazuju na značajni potencijal plodova i tradicionalnih proizvoda ispitivanih vrsta Rosa za upotrebu u proizvodnji nutraceutika i funkcionalne hrane. p> The aim of presented doctoral thesis was investigation of phytochemical composition and biological activity of water and methanol extracts of fresh and air- dried rose hips, as well as purée and jam made according to traditional recipe of hips of six wild growing Rosa L. species: R. canina, R. dumalis, R. dumetorum, R. tomentosa, R. arvensis, and R. sempervirens. Examination of…p> Advisors/Committee Members: Beara (Krstić) Ivana, Mimica-Dukić Neda, Anačkov Goran, Četojević-Simin Dragana, Lesjak Marija.

Subjects/Keywords: Rosa canina, R. dumalis, R. dumetorum, R. tomentosa, R. arvensis, R. sempervirens, ekstrakti, svež plod, suv plod, voćna kaša, džem, fenolni profil, vitamin C, antioksidantna aktivnost, antiinflamatorna aktivnost, antiacetilholinesterazna aktivnost, citotoksična aktivnost.; Rosa canina, R. dumalis, R. dumetorum, R. tomentosa, R. arvensis, R. sempervirens, extracts, fresh rose hips, air-dried rose hips, purée, jam, phenolic profile, vitamin C, antioxidant activity, anti-inflammatory activity , anti-acetylcholinesterase activity, cytotoxic activity.UC

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jelena, N. (2017). Fitohemijski skrining i biološka aktivnost ekstrakata i tradicionalnih proizvoda od plodova divljih ruža (Rosa L.;Rosaceae). (Thesis). University of Novi Sad. Retrieved from https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija14920720204088.pdf?controlNumber=(BISIS)104437&fileName=14920720204088.pdf&id=7373&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=104437&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jelena, Nađpal. “Fitohemijski skrining i biološka aktivnost ekstrakata i tradicionalnih proizvoda od plodova divljih ruža (Rosa L.;Rosaceae).” 2017. Thesis, University of Novi Sad. Accessed March 03, 2021. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija14920720204088.pdf?controlNumber=(BISIS)104437&fileName=14920720204088.pdf&id=7373&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=104437&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jelena, Nađpal. “Fitohemijski skrining i biološka aktivnost ekstrakata i tradicionalnih proizvoda od plodova divljih ruža (Rosa L.;Rosaceae).” 2017. Web. 03 Mar 2021.

Vancouver:

Jelena N. Fitohemijski skrining i biološka aktivnost ekstrakata i tradicionalnih proizvoda od plodova divljih ruža (Rosa L.;Rosaceae). [Internet] [Thesis]. University of Novi Sad; 2017. [cited 2021 Mar 03]. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija14920720204088.pdf?controlNumber=(BISIS)104437&fileName=14920720204088.pdf&id=7373&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=104437&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jelena N. Fitohemijski skrining i biološka aktivnost ekstrakata i tradicionalnih proizvoda od plodova divljih ruža (Rosa L.;Rosaceae). [Thesis]. University of Novi Sad; 2017. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija14920720204088.pdf?controlNumber=(BISIS)104437&fileName=14920720204088.pdf&id=7373&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=104437&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Ben Jouira, Rania. Implication de la matrice extracellulaire tumorale dans la transition phénotypique et la résistance aux thérapies ciblées du mélanome : Role of cancer cell derived extracellular matrix in phenotype switching and therapy resistance in melanoma.

Degree: Docteur es, Interactions moléculaires et cellulaires, 2017, Université Côte d'Azur (ComUE)

URL: http://www.theses.fr/2017AZUR4140

► Le mélanome cutané est le cancer de la peau le plus agressif de par sa grande plasticité phénotypique, son fort caractère métastatique et sa résistance… (more)

▼ Le mélanome cutané est le cancer de la peau le plus agressif de par sa grande plasticité phénotypique, son fort caractère métastatique et sa résistance aux traitements. L’émergence d’inhibiteurs ciblant la forme mutée de la kinase BRAF (BRAF V600E) a produit des réponses thérapeutiques spectaculaires, malheureusement suivies par l’apparition rapide de résistances secondaires très agressives. La compréhension des mécanismes cellulaires et moléculaires impliqués dans ces résistances constitue donc un prérequis indispensable à l’amélioration de ces thérapies ciblées. A côté des altérations intrinsèques au mélanome, les interactions entre les cellules malignes et leur microenvironnement favorisent la survie tumorale et contribuent à la résistance aux thérapies. En particulier, la matrice extracellulaire (MEC), qui constitue un réseau dynamique de macromolécules de composition et de propriétés physico-chimiques variables, influence l’architecture des tissus tumoraux, l’invasion et la réponse aux traitements. De façon importante, l’acquisition par les cellules de mélanome d’un phénotype mésenchymateux invasif a été décrite comme un mécanisme d’échappement aux thérapies ciblant la mutation oncogénique de BRAF. Dans ce contexte, l’objectif de mon travail de thèse a été de préciser le rôle de cette signature phénotypique sur les propriétés bio-mécaniques des cellules de mélanome et la réponse aux thérapies ciblées. Dans la première partie de ma thèse, j’ai observé que les cellules résistantes présentant un phénotype invasif mésenchymateux produisent, assemblent et remodèlent une matrice ayant des propriétés mécaniques et biochimiques proches de myofibroblastes. Ce phénotype est associé à une activation de la voie YAP/TAZ et une mécano-sensibilité amplifiée. La caractérisation par spectrométrie de masse du matrisome des cellules résistantes a révélé la présence abondante de protéines matricielles comme la Fibronectine, le Collagène 1(I) et la THBS1 mais également de protéines de réticulation du collagène comme LOXL2 et TGM2. Nos données montrent aussi que ces modifications sont conférées de novo par un traitement aux inhibiteurs de BRAF ou de MEK dans des cellules de mélanome mutées BRAF in vitro, et que chez la souris le traitement au Vémurafénib de cellules de mélanome xénogreffées induit l’assemblage de fibres de collagène associé à une rigidification tumorale. Finalement, j’ai pu montrer que la matrice produite par les cellules mésenchymales résistantes protège les cellules de mélanome naïves des effets anti-prolifératifs liées à l’inhibition de BRAF ou MEK. Dans une deuxième partie de ma thèse, je me suis intéressée à la protéine de réticulation du collagène de la famille des lysyl oxidases (LOX), LOXL2 exprimée par les cellules mésenchymales résistantes. Nos analyses bioinformatiques et biochimiques montrent que l'expression de cette enzyme est fortement associée à la signature invasive MITFlow AXLhigh des mélanomes. En utilisant des approches d'interférence à ARN, j'ai aussi montré que la suppression de LOXL2 dans les… Advisors/Committee Members: Deckert, Marcel (thesis director).

Subjects/Keywords: Mélanome; Thérapies ciblées; Résistance; BRAF; Matrice extracellulaire; Melanoma; Targeted therapies; BRAF; ECM; Drug resistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ben Jouira, R. (2017). Implication de la matrice extracellulaire tumorale dans la transition phénotypique et la résistance aux thérapies ciblées du mélanome : Role of cancer cell derived extracellular matrix in phenotype switching and therapy resistance in melanoma. (Doctoral Dissertation). Université Côte d'Azur (ComUE). Retrieved from http://www.theses.fr/2017AZUR4140

Chicago Manual of Style (16^th Edition):

Ben Jouira, Rania. “Implication de la matrice extracellulaire tumorale dans la transition phénotypique et la résistance aux thérapies ciblées du mélanome : Role of cancer cell derived extracellular matrix in phenotype switching and therapy resistance in melanoma.” 2017. Doctoral Dissertation, Université Côte d'Azur (ComUE). Accessed March 03, 2021. http://www.theses.fr/2017AZUR4140.

MLA Handbook (7^th Edition):

Ben Jouira, Rania. “Implication de la matrice extracellulaire tumorale dans la transition phénotypique et la résistance aux thérapies ciblées du mélanome : Role of cancer cell derived extracellular matrix in phenotype switching and therapy resistance in melanoma.” 2017. Web. 03 Mar 2021.

Vancouver:

Ben Jouira R. Implication de la matrice extracellulaire tumorale dans la transition phénotypique et la résistance aux thérapies ciblées du mélanome : Role of cancer cell derived extracellular matrix in phenotype switching and therapy resistance in melanoma. [Internet] [Doctoral dissertation]. Université Côte d'Azur (ComUE); 2017. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2017AZUR4140.

Council of Science Editors:

Ben Jouira R. Implication de la matrice extracellulaire tumorale dans la transition phénotypique et la résistance aux thérapies ciblées du mélanome : Role of cancer cell derived extracellular matrix in phenotype switching and therapy resistance in melanoma. [Doctoral Dissertation]. Université Côte d'Azur (ComUE); 2017. Available from: http://www.theses.fr/2017AZUR4140

15. Kalameya, Jens. Zur Tragfähigkeit von druck- und biegebeanspruchten C-Profilen aus Stahl.

Degree: 2008, Technische Universität Dortmund

URL: http://hdl.handle.net/2003/26028

► In der Baupraxis spielen C-Profile oder U-Profile aus Stahl eine große Rolle. Sie kommen im allgemeinen Hochbau beispielsweise als Wandriegel, Pfetten und Stützen von Stahlhallenbauten… (more)

▼ In der Baupraxis spielen C-Profile oder U-Profile aus Stahl eine große Rolle. Sie kommen im allgemeinen Hochbau beispielsweise als Wandriegel, Pfetten und Stützen von Stahlhallenbauten zum Einsatz und sind somit i. d. R. sowohl druck- als auch biegebeansprucht. Die Regelungen und Nachweiskonzepte in den maßgeblichen Stahlbaunormen DIN 18800 und Eurocode 3, insbesondere zur Stab- und Gesamtstabilität von Bauteilen unter Normalspannungen, sind weitestgehend durch Untersuchungen an I- und Kastenprofilen hergeleitet und verifiziert worden. Eine Übertragung und Überprüfung für davon abweichende Profilformen, im Speziellen für die hier behandelten C-Profile, existiert jedoch nicht. In der vorliegenden Arbeit wird ein geschlossenes, durchgängiges Bemessungskonzept vorgestellt, das es erlaubt, das Tragverhalten von Bauteilen mit C-förmigem Querschnitt ohne längsaussteifende Querschnittselemente unter Druck- und/oder Biegebeanspruchung wirklichkeitsnah zu beschreiben und rechnerisch zu erfassen. Dabei wurde der Betrachtung der auftretenden Stabilitätsprobleme, d.h. lokalem Plattenbeulen, globaler Stabstabilität und dem Zusammenspiel bei der einzelnen Stabilitätsprobleme besondere Aufmerksamkeit geschenkt. Es wurden aktuelle Erkenntnisse aus Forschungen zur Querschnitts- und Stabtragfähigkeit im Bemessungsvorschlag integriert, sodass das reale Tragverhalten wirklichkeitsnah beschrieben werden kann und eine möglichst wirtschaftliche Dimensionierung der Bauteile erreicht wird. Grundsätzlich wurde Wert darauf gelegt, dass das Bemessungskonzept modular aus Einzelbausteinen zusammengesetzt wird, um die Grenzübergänge bei Wegfall eines Stabilitätseinflusses bzw. einer Beanspruchungskomponente konfliktfrei zu gewährleisten. Der Bemessungsvorschlag wurde als Handrechenverfahren auf Basis des in der Ingenieurpraxis etablierten Ersatzstabverfahrens formuliert, das die Vorteile einer effizienten Nachweisführung und der Möglichkeit der Ergebniskontrolle in einem guten Kompromiss miteinander verbindet. Zudem wurde darauf geachtet, dass die mögliche erreichbare Materialersparnis nicht durch einen erhöhten Rechenaufwand für den in der Praxis tätigen Ingenieur erkauft wird. Es wurden umfangreiche Berechnungshilfen rechnerischer und graphischer Art bereitgestellt, die trotz des mitunter komplexen Tragverhaltens eine einfache Rechnung von Hand erlauben. Die Güte des Bemessungskonzeptes wurde anhand einer umfangreichen Datenbasis aus numerischen und experimentellen Untersuchungen überprüft. Dabei ergab sich durchweg eine wirtschaftliche aber sichere rechnerische Prognose der Bauteiltragfähigkeiten. p>Steel channel sections play an important role in building construction. They are commonly used as side rails, purlins and columns in industrial halls and thus are loaded by compression forces and bending moments. Especially for members susceptible to global buckling or coupled instabilities the design rules in the relevant codes DIN 18800 and Eurocode 3 have been developed for and verified by research on I-shaped or hollow sections. For deviant…p> Advisors/Committee Members: Ungermann, Dieter.

Subjects/Keywords: Beulen; Biegedrillknicken; Biegeknicken; C-Profil; Stabilität; Stahlbau; U-Profil; 690

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kalameya, J. (2008). Zur Tragfähigkeit von druck- und biegebeanspruchten C-Profilen aus Stahl. (Thesis). Technische Universität Dortmund. Retrieved from http://hdl.handle.net/2003/26028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kalameya, Jens. “Zur Tragfähigkeit von druck- und biegebeanspruchten C-Profilen aus Stahl.” 2008. Thesis, Technische Universität Dortmund. Accessed March 03, 2021. http://hdl.handle.net/2003/26028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kalameya, Jens. “Zur Tragfähigkeit von druck- und biegebeanspruchten C-Profilen aus Stahl.” 2008. Web. 03 Mar 2021.

Vancouver:

Kalameya J. Zur Tragfähigkeit von druck- und biegebeanspruchten C-Profilen aus Stahl. [Internet] [Thesis]. Technische Universität Dortmund; 2008. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2003/26028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kalameya J. Zur Tragfähigkeit von druck- und biegebeanspruchten C-Profilen aus Stahl. [Thesis]. Technische Universität Dortmund; 2008. Available from: http://hdl.handle.net/2003/26028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

16. Chowdhury, Sanjana. Predictors of Cancer Cell Response to Metformin.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/80606

► There is great interest in transitioning the antidiabetic drug metformin for use in cancer, with evidence suggesting it can improve outcome following radiotherapy (RT). Its… (more)

Subjects/Keywords: Biomarkers; Cancer; Drug Repositioning; Metabolism; Metformin; Radiotherapy; 0992

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chowdhury, S. (2014). Predictors of Cancer Cell Response to Metformin. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/80606

Chicago Manual of Style (16^th Edition):

Chowdhury, Sanjana. “Predictors of Cancer Cell Response to Metformin.” 2014. Masters Thesis, University of Toronto. Accessed March 03, 2021. http://hdl.handle.net/1807/80606.

MLA Handbook (7^th Edition):

Chowdhury, Sanjana. “Predictors of Cancer Cell Response to Metformin.” 2014. Web. 03 Mar 2021.

Vancouver:

Chowdhury S. Predictors of Cancer Cell Response to Metformin. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1807/80606.

Council of Science Editors:

Chowdhury S. Predictors of Cancer Cell Response to Metformin. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/80606

University of Toronto

17. Chowdhury, Sanjana. Predictors of Cancer Cell Response to Metformin.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/80605

► There is great interest in transitioning the antidiabetic drug metformin for use in cancer, with evidence suggesting it can improve outcome following radiotherapy (RT). Its… (more)

Subjects/Keywords: Biomarkers; Cancer; Drug Repositioning; Metabolism; Metformin; Radiotherapy; 0992

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chowdhury, S. (2014). Predictors of Cancer Cell Response to Metformin. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/80605

Chicago Manual of Style (16^th Edition):

Chowdhury, Sanjana. “Predictors of Cancer Cell Response to Metformin.” 2014. Masters Thesis, University of Toronto. Accessed March 03, 2021. http://hdl.handle.net/1807/80605.

MLA Handbook (7^th Edition):

Chowdhury, Sanjana. “Predictors of Cancer Cell Response to Metformin.” 2014. Web. 03 Mar 2021.

Vancouver:

Chowdhury S. Predictors of Cancer Cell Response to Metformin. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1807/80605.

Council of Science Editors:

Chowdhury S. Predictors of Cancer Cell Response to Metformin. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/80605

University of California – San Francisco

18. Taubes, Alice Lorraine. ApoE-Genotype-Specific Drug Repositioning Identifies Bumetanide as an Effective Compound in a Mouse Model of Alzheimer's Disease.

Degree: Biomedical Sciences, 2019, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/7n9604sm

► Alzheimer’s disease (AD) is the leading cause of dementia worldwide, and no effective therapies are available. The multifactorial etiology and pathophysiological complexity of AD cause… (more)

Subjects/Keywords: Neurosciences; Alzheimer's Disease; Drug Repositioning; Pharmacogenomics; Precision Medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Taubes, A. L. (2019). ApoE-Genotype-Specific Drug Repositioning Identifies Bumetanide as an Effective Compound in a Mouse Model of Alzheimer's Disease. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/7n9604sm

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Taubes, Alice Lorraine. “ApoE-Genotype-Specific Drug Repositioning Identifies Bumetanide as an Effective Compound in a Mouse Model of Alzheimer's Disease.” 2019. Thesis, University of California – San Francisco. Accessed March 03, 2021. http://www.escholarship.org/uc/item/7n9604sm.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Taubes, Alice Lorraine. “ApoE-Genotype-Specific Drug Repositioning Identifies Bumetanide as an Effective Compound in a Mouse Model of Alzheimer's Disease.” 2019. Web. 03 Mar 2021.

Vancouver:

Taubes AL. ApoE-Genotype-Specific Drug Repositioning Identifies Bumetanide as an Effective Compound in a Mouse Model of Alzheimer's Disease. [Internet] [Thesis]. University of California – San Francisco; 2019. [cited 2021 Mar 03]. Available from: http://www.escholarship.org/uc/item/7n9604sm.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Taubes AL. ApoE-Genotype-Specific Drug Repositioning Identifies Bumetanide as an Effective Compound in a Mouse Model of Alzheimer's Disease. [Thesis]. University of California – San Francisco; 2019. Available from: http://www.escholarship.org/uc/item/7n9604sm

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

19. Arat, Seda. A Systems Biology Approach to Microbiology and Cancer.

Degree: PhD, Mathematics, 2015, Virginia Tech

URL: http://hdl.handle.net/10919/75149

► Systems biology is an interdisciplinary field that focuses on elucidating complex biological processes (systems) by investigating the interactions among its components through an iterative cycle… (more)

▼ Systems biology is an interdisciplinary field that focuses on elucidating complex biological processes (systems) by investigating the interactions among its components through an iterative cycle composed of data generation, data analysis and mathematical modeling. Our contributions to systems biology revolve around the following two axes: - Data analysis: Two data analysis projects, which were initiated when I was a co-op at GlaxoSmithKline, are discussed in this thesis. First, next generation sequencing data generated for a phase I clinical trial is analyzed to determine the altered microbial community in human gut before and after antibiotic usage (Chapter 2). To our knowledge, there have not been similar comparative studies in humans on the impacts on the gut microbiome of an antibiotic when administered by different modes. Second, publicly available gene expression data is analyzed to investigate human immune response to tuberculosis (TB) infection (Chapter 3). The novel feature of this study is systematic drug repositioning for the prevention, control and treatment of TB using the Connectivity map. - Mathematical modeling: Polynomial dynamical systems, a state- and time- discrete logical modeling framework, is used to model two biological processes. First, a denitrification pathway in Pseudomonas aeruginosa is modeled to shed light on the reason of greenhouse gas nitrous oxide accumulation (Chapter 4). It is the first mathematical model of denitrification that can predict the effect of phosphate on the denitrification performance of this bacterium. Second, an iron homeostasis pathway linked to iron utilization, oxidative stress response and oncogenic pathways is constructed to investigate how normal breast cells become cancerous (Chapter 5). To date, our intracellular model is the only expanded core iron model that can capture a breast cancer phenotype by overexpression and knockout simulations. Advisors/Committee Members: Laubenbacher, Reinhard C. (committeechair), Hoops, Stefan (committee member), Ciupe, Mihaela Stanca (committee member), Burns, John A. (committee member).

Subjects/Keywords: data analysis; mathematical modeling; microbiome; drug repositioning; polynomial dynamical system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arat, S. (2015). A Systems Biology Approach to Microbiology and Cancer. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/75149

Chicago Manual of Style (16^th Edition):

Arat, Seda. “A Systems Biology Approach to Microbiology and Cancer.” 2015. Doctoral Dissertation, Virginia Tech. Accessed March 03, 2021. http://hdl.handle.net/10919/75149.

MLA Handbook (7^th Edition):

Arat, Seda. “A Systems Biology Approach to Microbiology and Cancer.” 2015. Web. 03 Mar 2021.

Vancouver:

Arat S. A Systems Biology Approach to Microbiology and Cancer. [Internet] [Doctoral dissertation]. Virginia Tech; 2015. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10919/75149.

Council of Science Editors:

Arat S. A Systems Biology Approach to Microbiology and Cancer. [Doctoral Dissertation]. Virginia Tech; 2015. Available from: http://hdl.handle.net/10919/75149

20. Cai, Xiaoshu. DEVELOPMENT OF COMPUTATIONAL APPROACH FOR DRUG DISCOVERY.

Degree: MSs, EECS - Computer and Information Sciences, 2016, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1465403528

► Computational drug discovery is still in its early stage. Effective approaches are needed to understand disease mechanisms and link disease to potential drug treatments through… (more)

Subjects/Keywords: Bioinformatics; Computer Science; Drug repositioning; Machine learning; LINCS; Cytokines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cai, X. (2016). DEVELOPMENT OF COMPUTATIONAL APPROACH FOR DRUG DISCOVERY. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1465403528

Chicago Manual of Style (16^th Edition):

Cai, Xiaoshu. “DEVELOPMENT OF COMPUTATIONAL APPROACH FOR DRUG DISCOVERY.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 03, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1465403528.

MLA Handbook (7^th Edition):

Cai, Xiaoshu. “DEVELOPMENT OF COMPUTATIONAL APPROACH FOR DRUG DISCOVERY.” 2016. Web. 03 Mar 2021.

Vancouver:

Cai X. DEVELOPMENT OF COMPUTATIONAL APPROACH FOR DRUG DISCOVERY. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 03]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1465403528.

Council of Science Editors:

Cai X. DEVELOPMENT OF COMPUTATIONAL APPROACH FOR DRUG DISCOVERY. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1465403528

21. Vechio, Aluana Maria da Costa Dal. Efeito apoptótico do Celecoxib em linhagens celulares derivadas de carcinoma epidermóide de boca.

Degree: PhD, Patologia Bucal, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-22092011-172726/ ;

► O Celecoxib, antiinflamatório não esteroidal, inibidor seletivo da COX-2, tem se mostrado um importante agente anticarcinogênico, mas o seu papel no carcinoma epidermóide de boca… (more)

▼ O Celecoxib, antiinflamatório não esteroidal, inibidor seletivo da COX-2, tem se mostrado um importante agente anticarcinogênico, mas o seu papel no carcinoma epidermóide de boca (CEB) não é totalmente compreendido. Sabe-se que diversas alterações genéticas estão associadas à patogênese do CEB, a neoplasia maligna mais comum de cabeça e pescoço. Algumas dessas alterações comprometem proteínas pertencentes à via de sinalização do Akt, envolvida em diferentes fenômenos celulares. É sabido que Akt pode ativar o fator de transcrição NF-kB, o qual tem importante participação na fisiologia normal e no câncer. A proteína COX-2, descrita inicialmente em processos inflamatórios, está associada com a oncogênese e recentemente tem sido associada com a via de sinalização do Akt e com o NF-kB. Portanto, o objetivo deste estudo foi analisar o efeito do Celecoxib sobre linhagens celulares de carcinoma epidermóide de boca e verificar a localização intracelular e a expressão das proteínas pAkt, NF-kB e COX-2 em linhagens celulares de carcinoma epiermóide de boca após o tratamento com o Celecoxib.Através da técnica de imunofluorescência, foram analisados os padrões de expressão das proteínas pAkt, NFkB e COX-2 em quatro linhagens celulares de carcinoma epidermóide bucal submetidas ao tratamento com Celecoxib, cuja a dose e o tempo foram obtidos a partir de ensaios de viabilidade celular. Também se realizou ensaio de apoptose celular. Como controle utilizou-se células não tratadas com o medicamento. O Celecoxib na dose de 30 M por 24 horas causa apoptose.Na técnica de western blot, somente a linhagem SCC15 apresentou uma diminuição significativa para a COX-2. Entretanto, para p-Akt e NF-kB nenhuma alteração na expressão foi observada entre os grupos controle e tratado.Na imunofluorescência, houve alteração no padrão de expressão das proteínas pAkt, NF-kB e COX-2, quando se comparou os grupos contrele e tratado. Portanto, o Celecoxib pode ser um eficaz agente terapêutico, uma vez que demonstrou grande eficácia na inibição da proliferação celular de linhagens celulares de CEB. p>Celecoxib, nonsteroidal anti-inflammatory COX-2 selective inhibitor, has proven to be an important anticancer agent. However its role in oral squamous cell carcinoma (OSCC) is not entirely understood. This is the most common malignancy of head and neck regionand it is known that various genetic alterations are associated with its pathogenesis. Some of these changes affect proteins belonging to the Akt signaling pathway, involved in different cellular processes. It is known that Akt can activate the transcription factor NF-kB, which has important role in normal physiology and cancer.The COX-2 proteinwas firstly described in the inflammatory processes, is associated with oncogenesis and has recently been related with the Akt signaling pathwayand with NF-kB. Therefore, the aim of this study was to analyze the effect of Celecoxib on squamous cell carcinoma cell lines and to determine pAkt, NF-kB and COX-2 intracellular localization and levels of expressionin this…p> Advisors/Committee Members: Pinto Júnior, Décio dos Santos.

Subjects/Keywords: Apoptose; Apoptosis; Carcinoma epidermóide; Celecoxib; Celecoxib; COX-2; COX-2; p-Akt/NF-kB pathway; Squamous cell carcinoma; Via de sinalização p-Akt/NF-kB

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vechio, A. M. d. C. D. (2011). Efeito apoptótico do Celecoxib em linhagens celulares derivadas de carcinoma epidermóide de boca. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23141/tde-22092011-172726/ ;

Chicago Manual of Style (16^th Edition):

Vechio, Aluana Maria da Costa Dal. “Efeito apoptótico do Celecoxib em linhagens celulares derivadas de carcinoma epidermóide de boca.” 2011. Doctoral Dissertation, University of São Paulo. Accessed March 03, 2021. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-22092011-172726/ ;.

MLA Handbook (7^th Edition):

Vechio, Aluana Maria da Costa Dal. “Efeito apoptótico do Celecoxib em linhagens celulares derivadas de carcinoma epidermóide de boca.” 2011. Web. 03 Mar 2021.

Vancouver:

Vechio AMdCD. Efeito apoptótico do Celecoxib em linhagens celulares derivadas de carcinoma epidermóide de boca. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Mar 03]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-22092011-172726/ ;.

Council of Science Editors:

Vechio AMdCD. Efeito apoptótico do Celecoxib em linhagens celulares derivadas de carcinoma epidermóide de boca. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-22092011-172726/ ;

Queensland University of Technology

22. Shah, Esha Tushit. Repositioning "old" drugs for new causes : identifying new treatments for prostate cancer.

Degree: 2015, Queensland University of Technology

URL: https://eprints.qut.edu.au/80103/

The majority of prostate cancer related deaths are due to the spread of the disease. This project developed a screening protocol to identify existing drugs that could be used to prevent the spread of prostate cancer and thereby improve the survival of the patients.

Subjects/Keywords: Prostate Cancer; Metastasis; Drug Repositioning; Cell migration; Multi-parameter Screen; Drug Screen

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APA (6^th Edition):

Shah, E. T. (2015). Repositioning "old" drugs for new causes : identifying new treatments for prostate cancer. (Thesis). Queensland University of Technology. Retrieved from https://eprints.qut.edu.au/80103/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shah, Esha Tushit. “Repositioning "old" drugs for new causes : identifying new treatments for prostate cancer.” 2015. Thesis, Queensland University of Technology. Accessed March 03, 2021. https://eprints.qut.edu.au/80103/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shah, Esha Tushit. “Repositioning "old" drugs for new causes : identifying new treatments for prostate cancer.” 2015. Web. 03 Mar 2021.

Vancouver:

Shah ET. Repositioning "old" drugs for new causes : identifying new treatments for prostate cancer. [Internet] [Thesis]. Queensland University of Technology; 2015. [cited 2021 Mar 03]. Available from: https://eprints.qut.edu.au/80103/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shah ET. Repositioning "old" drugs for new causes : identifying new treatments for prostate cancer. [Thesis]. Queensland University of Technology; 2015. Available from: https://eprints.qut.edu.au/80103/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Dai, Yuheng. The Commercilazation of a Noval Antithrombotic Drug.

Degree: MSs, Biology, 2018, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038

► Thrombotic events are the main cause of morbidity and mortality in developed countries, and continue to be an important focus for new therapeutic research. A… (more)

Subjects/Keywords: Biology; Medicine; Thymidine phosphorylase, platelet, thrombosis, anti-platelet therapy, commercialization, drug repositioning, drug repurposing

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APA (6^th Edition):

Dai, Y. (2018). The Commercilazation of a Noval Antithrombotic Drug. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038

Chicago Manual of Style (16^th Edition):

Dai, Yuheng. “The Commercilazation of a Noval Antithrombotic Drug.” 2018. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 03, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038.

MLA Handbook (7^th Edition):

Dai, Yuheng. “The Commercilazation of a Noval Antithrombotic Drug.” 2018. Web. 03 Mar 2021.

Vancouver:

Dai Y. The Commercilazation of a Noval Antithrombotic Drug. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2018. [cited 2021 Mar 03]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038.

Council of Science Editors:

Dai Y. The Commercilazation of a Noval Antithrombotic Drug. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038

University of Manchester

24. Del Castillo frias, Maria Priscila. Optimisation and use of cell-based assays and in vivo assay for screening drugs for Alzheimer's Disease.

Degree: 2017, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:311863

► Alzheimer's Disease (AD) is the most prevalent form of dementia among elderly people. This disease is a major world health issue as the numbers of… (more)

▼ Alzheimer's Disease (AD) is the most prevalent form of dementia among elderly people. This disease is a major world health issue as the numbers of patients with this type of dementia will significantly increase in the next few decades. The aetiology of AD is not completely fully understood. The amyloid cascade hypothesis that identifies Beta-amyloid peptide (AB) as the initiator of the AD pathology leads the drug development efforts for AD. Currently only five drugs are approved by the FDA for AD but these drugs just ameliorate the symptoms of the disease for a limited time and do not target the underlaying pathology. Unfortunately, none of the drugs targeting the underlying disease has fully succeeded in clinical trials. In this project, we screened a drug library of 174 compounds that have been previously approved and/or undergone clinical trials and five drugs that have been previously identified to have a potential effect as AD therapies. We used SH-SY5Y cells acutely treated with AB42, and SH-SY5Y695 cells, as models to mimic the neurotoxic effects of AB in AD. First, we evaluated the feasibility and optimised different in vitro assays to be used as primary and secondary screening assays. MTT was selected as one of the primary screening methods as cells treated with AB42 decreased MTT reduction compared to non-treated cells. Mesoscale Discovery (MSD) immunoassays were also selected as another primary screening assay using SH-SY5Y695 cells. This immunoassay allowed us to simultaneously measure the concentration of the following proteins involved in APP processing: sAPP-alpha, sAPPB, AB38, AB40 and AB42. The primary screening using MTT identified SEN304, EGCG and castalagin as hits. MSD immunoassays identified compounds 4 (Acetyl-beta-methylcholine), 8 (arecoline), 133 (Tranylprimine), 169 (tropisetron), castalagin and SEN304 as possible hits. The first part of secondary screening focused on assessing the potency of the hits identified from the MTT primary screening and evaluating the possible advantage of a two-drug combination approach. EGCG was the most potent compound at inhibiting AB toxicity measured by MTT, followed by SEN304, castalagin and vescalagin. The two-drug combination approach did not show any synergetic effect. The second part of the secondary screening focused in assessing whether the hits from both MT and MSD immunoassays could hinder the increase of ROS generated in SH-SY5Y cells treated with AB42. EGCG was the only drug that decreased the ROS caused by AB42. A Drosophila melanogaster model overexpressing AB42 decreased the longevity of fruit flies compared to a control fly model not expressing AB We performed survival assays to evaluate whether EGCG or SEN304 increased the lifespan of the AB42 flies. None of the drugs evaluated increased the life span of flies overexpressing AB42. Overall the assays presented in this thesis allowed us to identify possible hits for the treatment of AD. The results suggest that SEN304, EGCG, vescalagin an castalagin have multiple mechanism of action to inhibit… Advisors/Committee Members: PROKOP, ANDREAS A, Doig, Andrew, Prokop, Andreas.

Subjects/Keywords: Alzheimer's Disease; Drug screening; Drug repositioning; drosophila melanogaster; cell-based assays; MTT

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Del Castillo frias, M. P. (2017). Optimisation and use of cell-based assays and in vivo assay for screening drugs for Alzheimer's Disease. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:311863

Chicago Manual of Style (16^th Edition):

Del Castillo frias, Maria Priscila. “Optimisation and use of cell-based assays and in vivo assay for screening drugs for Alzheimer's Disease.” 2017. Doctoral Dissertation, University of Manchester. Accessed March 03, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:311863.

MLA Handbook (7^th Edition):

Del Castillo frias, Maria Priscila. “Optimisation and use of cell-based assays and in vivo assay for screening drugs for Alzheimer's Disease.” 2017. Web. 03 Mar 2021.

Vancouver:

Del Castillo frias MP. Optimisation and use of cell-based assays and in vivo assay for screening drugs for Alzheimer's Disease. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Mar 03]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:311863.

Council of Science Editors:

Del Castillo frias MP. Optimisation and use of cell-based assays and in vivo assay for screening drugs for Alzheimer's Disease. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:311863

25. Rouault, Audrey. Etude génomique des cancers du sein familiaux liés à une mutation constitutionnelle du gène BRCA2 : Gene expression and genomic profile study of BRCA2-mutant breast tumors.

Degree: Docteur es, Sciences, technologie, santé. Génétique, 2013, Université de Bordeaux Segalen

URL: http://www.theses.fr/2013BOR22122

► L’altération constitutionnelle des gènes BRCA1 et BRCA2 est détectée dans 20 à 30% des formes familiales de cancer du sein. La fréquence de mise en… (more)

▼ L’altération constitutionnelle des gènes BRCA1 et BRCA2 est détectée dans 20 à 30% des formes familiales de cancer du sein. La fréquence de mise en évidence d’une mutation BRCA2 selon des critères généalogiques reste modeste. La définition de caractéristiques tumorales communes aux tumeurs du sein survenant dans un contexte de prédisposition lié à BRCA2 a pour objectif l’identification de caractéristiques propres aux tumeurs BRCA2 permettant de mieux définir les indications de recherche de mutation de ce gène, et l’identification de facteurs impliqués dans la tumorigénèse des cancers du sein liés à BRCA2. L’étude des profils génomiques des tumeurs BRCA2 a caractérisé la délétion récurrente des bras longs des chromosomes 13 et 14. L’analyse supervisée des données d’expression entre les tumeurs BRCA2 et les tumeurs familiales BRCAX a identifié une signature spécifique des tumeurs BRCA2. Les exomes des chromosomes 13 & 14 pour 5 tumeurs informatives et leur ADN constitutionnel ont été séquencés afin d’identifier la ou les cibles des régions délétées. Cette analyse a permis la caractérisation de variants somatiques qui seront à étudier dans une large série de cas BRCA2 et contrôles pour conclure sur leur rôle dans la tumorigénèse liée à BRCA2.La caractérisation de pertes de matériel chromosomique spécifiques aux tumeurs BRCA2, rapportée dans plusieurs études, offre une perspective diagnostique avec le développement d’un test FISH utilisable en pratique clinique pour préciser les indications d’une recherche de mutation du gène BRCA2, mais suggère également la présence de gènes cibles candidats dont l’inactivation est requise lors de la cancérisation mammaire liée à BRCA2. p>Germline BRCA1 and BRCA2 mutations account for 20-30% of familial breast cancer. The main indication for BRCA2 screening is a family history, but the mutation detection rate in patients selected this way is low. The identification of characteristics common to BRCA2-associated tumors would improve the criteria used to select patients for BRCA2 screening and could identify factors implicated in BRCA2-mutant breast cancer tumorigenesis. The analysis of BRCA2-mutant breast tumor genomic profiles identified deletions of chromosomes 13q and 14q as a common feature of BRCA2-tumors. Supervised gene expression analysis of BRCA2-mutant breast tumors and familial breast tumors without germline BRCA1 or BRCA2 mutations identified a specific BRCA2 gene signature. Exome sequencing of chromosomes 13q and 14q for 5 BRCA2-mutant tumors, and their associated germline DNA was performed in order to identify the target(s) of the specific genomic deletions in the BRCA2 tumors. This analysis characterized somatic variants that will be screened for in a larger cohort of BRCA2 and control tumors cases to explore their role in BRCA2-mutant breast cancer. Our study identified deletions of chromosomes 13q and 14q as a common feature of tumors with germline BRCA2 mutations, as has been observed in several previous studies. We suggest that FISH analysis for the deletion of these…p> Advisors/Committee Members: Sevenet, Nicolas (thesis director).

Subjects/Keywords: Tumeurs du sein héréditaires; BRCA2; Signature transcriptomique; Profil génomique; NGS; Hereditary breast cancer, , , ,; BRCA2; Gene expression signature; Genomic profile; NGS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rouault, A. (2013). Etude génomique des cancers du sein familiaux liés à une mutation constitutionnelle du gène BRCA2 : Gene expression and genomic profile study of BRCA2-mutant breast tumors. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2013BOR22122

Chicago Manual of Style (16^th Edition):

Rouault, Audrey. “Etude génomique des cancers du sein familiaux liés à une mutation constitutionnelle du gène BRCA2 : Gene expression and genomic profile study of BRCA2-mutant breast tumors.” 2013. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed March 03, 2021. http://www.theses.fr/2013BOR22122.

MLA Handbook (7^th Edition):

Rouault, Audrey. “Etude génomique des cancers du sein familiaux liés à une mutation constitutionnelle du gène BRCA2 : Gene expression and genomic profile study of BRCA2-mutant breast tumors.” 2013. Web. 03 Mar 2021.

Vancouver:

Rouault A. Etude génomique des cancers du sein familiaux liés à une mutation constitutionnelle du gène BRCA2 : Gene expression and genomic profile study of BRCA2-mutant breast tumors. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2013. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2013BOR22122.

Council of Science Editors:

Rouault A. Etude génomique des cancers du sein familiaux liés à une mutation constitutionnelle du gène BRCA2 : Gene expression and genomic profile study of BRCA2-mutant breast tumors. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2013. Available from: http://www.theses.fr/2013BOR22122

East Tennessee State University

26. Cooper, Dustin. An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents.

Degree: PhD, Biomedical Sciences, 2016, East Tennessee State University

URL: https://dc.etsu.edu/etd/3024

► Drug based nanoparticle (NP) formulations have gained considerable attention over the past decade for their use in various drug delivery systems. NPs have been… (more)

▼ Drug based nanoparticle (NP) formulations have gained considerable attention over the past decade for their use in various drug delivery systems. NPs have been shown to increase bioavailability, decrease side effects of highly toxic drugs, and prolong drug release. Furthermore, polymer based, biodegradable nanodelivery has become increasing popular in the field of NP formulation because of their high degree of compatibility and low rate of toxicity. Due to their popularity, commercially available polymers such as poly lactic acid (PLA), poly glycolic acid (PGA) and polylactic-co-glycolic acid (PLGA) are commonly used in the development and design of new nano based delivery systems. Nonsteriodal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of pain and inflammation. NSAIDs such as diclofenac and celecoxib function by blocking cyclooxygenase expression and reducing prostaglandin synthesis. Unfortunately, the pharmacological actions of NSAIDs can lead to the development of several adverse side effects such as gastrointestinal ulceration and bleeding. The aim of this study was to formulate and optimize diclofenac or celecoxib entrapped polymer NPs using an emulsion-diffusion-evaporation technique. NP formulations were evaluated based on specific formula parameters such as particle size, zeta potential, morphology, and entrapment efficiency. Effects of stabilizer type, stabilizer concentration, centrifugal force, drug amount, and/or emulsifier (lecithin) on nanoparticle characterization were examined for formula optimization. Results of the formulation studies showed that NPs developed using polylactide-co-glycolide (PLGA) polymers and the stabilizer didodecyldimethylammonium bromide (DMAB) demonstrated enhanced stability, drug entrapment, and reduced particle size. These findings demonstrate an effective method for polymer NP formulation of diclofenac or celecoxib. Furthermore, the results reported herein support a novel method of drug delivery that may function to reduce known adverse effects of these pharmacotherapeutic agents.

Subjects/Keywords: Nanoparticle; Formulation; Drug Delivery; Polymer; DMAB; PVA; Celecoxib; Diclofenac; PLGA; Zeta Potential; Nanomedicine; Pharmaceutics and Drug Design

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APA (6^th Edition):

Cooper, D. (2016). An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents. (Doctoral Dissertation). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/3024

Chicago Manual of Style (16^th Edition):

Cooper, Dustin. “An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents.” 2016. Doctoral Dissertation, East Tennessee State University. Accessed March 03, 2021. https://dc.etsu.edu/etd/3024.

MLA Handbook (7^th Edition):

Cooper, Dustin. “An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents.” 2016. Web. 03 Mar 2021.

Vancouver:

Cooper D. An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents. [Internet] [Doctoral dissertation]. East Tennessee State University; 2016. [cited 2021 Mar 03]. Available from: https://dc.etsu.edu/etd/3024.

Council of Science Editors:

Cooper D. An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents. [Doctoral Dissertation]. East Tennessee State University; 2016. Available from: https://dc.etsu.edu/etd/3024

Marshall University

27. Treadway, Cierra. Is Preoperative Administration of Celecoxib and Pregabalin Associated with Decreased Intraoperative and Postoperative Opioid Consumption in Patients Undergoing Total Hip or Knee Arthroplasty?.

Degree: 2018, Marshall University

URL: https://mds.marshall.edu/etd/1117

► The purpose of this study was to determine if a preoperative dose of celecoxib and pregabalin in patients who underwent total hip arthroplasty (THA) or… (more)

▼ The purpose of this study was to determine if a preoperative dose of celecoxib and pregabalin in patients who underwent total hip arthroplasty (THA) or total knee arthroplasty (TKA) was associated with less opioid consumption intraoperatively and postoperatively compared to those who did not receive this regimen. Introduction: THA and TKA have been associated with a high incidence of postoperative pain. Historically, this pain has been managed with opioids; however, these drugs have negative side effects associated with their use. Consequently, anesthesia providers have begun utilizing multimodal non-opioid analgesics. Recently, a specific combination has been utilized, which includes a nonsteroidal anti-inflammatory drug known as celecoxib (Celebrex) and an anticonvulsant known as pregabalin (Lyrica). While this combination may be a beneficial alternative for opioids, there is no consensus on the timeliness or effectiveness of a single combination dose of these drugs at alleviating perioperative pain. Methodology: A retrospective cross-sectional study design was utilized for this study that included 200 patients who underwent THA or TKA between May 1, 2008 and May 1, 2018 at Charleston Area Medical Center. A total of 100 patients were included in group one, which consisted of patients who did not receive a preoperative dose of celecoxib and pregabalin or any other preoperative analgesics. Group two consisted of 100 patients who did receive a preoperative dose of both celecoxib and pregabalin. The primary independent variable was the preoperative administration of celecoxib and pregabalin. Secondary independent variables consisted of gender, age, body mass index (BMI), and American Society of Anesthesiologists (ASA) physical classification scores. The dependent variables consisted of intraoperative opioid consumption and total opioid consumption in the postoperative anesthesia care unit (PACU). Control variables consisted of gender, age, BMI and ASA physical classification scores. The research hypotheses were that patient who underwent THA or TKA and received preoperative doses of both celecoxib and pregabalin would have less opioid consumption in the intraoperative period and less opioid consumption in the PACU, compared to those who did not receive the same combination preoperatively. Results: Comparison of the two groups yielded no differences between mean age, BMI or gender. The mean age and ASA classification between the two groups were statistically different, p=.0001 and p=.017. Group one consisted of 55 females and 45 males, while group two consisted of 52 females and 48 males. The study also revealed there was a statistical significance in terms of PACU opioid consumption (p=.001) between the two groups but no statistical difference in intraoperative opioid consumption (p>.05). Group one received a mean difference of approximately 1.2 morphine equivalents more than group two. There was no statistical significance between PACU opioid consumption and age, gender, BMI, or ASA classification. Analysis showed…

Subjects/Keywords: Arthroplasty; celecoxib; opioid; pregabalin; pain; <; p>; Anesthesia – Research.<; /p>; <; p>; Anesthesiology – Research.<; /p>;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Treadway, C. (2018). Is Preoperative Administration of Celecoxib and Pregabalin Associated with Decreased Intraoperative and Postoperative Opioid Consumption in Patients Undergoing Total Hip or Knee Arthroplasty?. (Thesis). Marshall University. Retrieved from https://mds.marshall.edu/etd/1117

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Treadway, Cierra. “Is Preoperative Administration of Celecoxib and Pregabalin Associated with Decreased Intraoperative and Postoperative Opioid Consumption in Patients Undergoing Total Hip or Knee Arthroplasty?.” 2018. Thesis, Marshall University. Accessed March 03, 2021. https://mds.marshall.edu/etd/1117.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Treadway, Cierra. “Is Preoperative Administration of Celecoxib and Pregabalin Associated with Decreased Intraoperative and Postoperative Opioid Consumption in Patients Undergoing Total Hip or Knee Arthroplasty?.” 2018. Web. 03 Mar 2021.

Vancouver:

Treadway C. Is Preoperative Administration of Celecoxib and Pregabalin Associated with Decreased Intraoperative and Postoperative Opioid Consumption in Patients Undergoing Total Hip or Knee Arthroplasty?. [Internet] [Thesis]. Marshall University; 2018. [cited 2021 Mar 03]. Available from: https://mds.marshall.edu/etd/1117.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Treadway C. Is Preoperative Administration of Celecoxib and Pregabalin Associated with Decreased Intraoperative and Postoperative Opioid Consumption in Patients Undergoing Total Hip or Knee Arthroplasty?. [Thesis]. Marshall University; 2018. Available from: https://mds.marshall.edu/etd/1117

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

28. Császi, Fruzsina Orsolya. Management és engagement - CSR elemek a MOL csoport "Kisütöttük, ide vele!" integrált pr kampányában .

Degree: DE – TEK – Bölcsészettudományi Kar, 2013, University of Debrecen

URL: http://hdl.handle.net/2437/176904

A szakdolgozat a MOL csoport legújabb integrált marketing-pr kampányát elemzi és a nemzetközi CSR és integrált kommunikációs trendeket foglalja össze. Advisors/Committee Members: Oláh, Szabolcs (advisor).

Subjects/Keywords: MOL; integrált

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Császi, F. O. (2013). Management és engagement - CSR elemek a MOL csoport "Kisütöttük, ide vele!" integrált pr kampányában . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/176904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Császi, Fruzsina Orsolya. “Management és engagement - CSR elemek a MOL csoport "Kisütöttük, ide vele!" integrált pr kampányában .” 2013. Thesis, University of Debrecen. Accessed March 03, 2021. http://hdl.handle.net/2437/176904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Császi, Fruzsina Orsolya. “Management és engagement - CSR elemek a MOL csoport "Kisütöttük, ide vele!" integrált pr kampányában .” 2013. Web. 03 Mar 2021.

Vancouver:

Császi FO. Management és engagement - CSR elemek a MOL csoport "Kisütöttük, ide vele!" integrált pr kampányában . [Internet] [Thesis]. University of Debrecen; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2437/176904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Császi FO. Management és engagement - CSR elemek a MOL csoport "Kisütöttük, ide vele!" integrált pr kampányában . [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/176904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

29. Jeremić-Gvozdenović, Jelena, 1969-, 35405159. Mehanizam nastanka heterotopne osifikacije i koncipiranje odgovarajućeg tretmana.

Degree: Tehnološko-metalurški fakultet, 2020, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:21066/bdef:Content/get

► Tehnološko inženjerstvo - Biohemijsko inženjerstvo i biotehnologija / Technological engineering - Biochemical engineering and biotechnology p>Skeletni sistem je kompleksan organ koji se formira tokom embriogeneze,… (more)

Subjects/Keywords: Heterotopic ossification; Mesenchymal stem cells (MSC); Hedgehog signaling; Arsenic trioxide; Vitamin D3; statin; drug repositioning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jeremić-Gvozdenović, Jelena, 1. (2020). Mehanizam nastanka heterotopne osifikacije i koncipiranje odgovarajućeg tretmana. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:21066/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jeremić-Gvozdenović, Jelena, 1969-,. “Mehanizam nastanka heterotopne osifikacije i koncipiranje odgovarajućeg tretmana.” 2020. Thesis, Univerzitet u Beogradu. Accessed March 03, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:21066/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jeremić-Gvozdenović, Jelena, 1969-,. “Mehanizam nastanka heterotopne osifikacije i koncipiranje odgovarajućeg tretmana.” 2020. Web. 03 Mar 2021.

Vancouver:

Jeremić-Gvozdenović, Jelena 1. Mehanizam nastanka heterotopne osifikacije i koncipiranje odgovarajućeg tretmana. [Internet] [Thesis]. Univerzitet u Beogradu; 2020. [cited 2021 Mar 03]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:21066/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jeremić-Gvozdenović, Jelena 1. Mehanizam nastanka heterotopne osifikacije i koncipiranje odgovarajućeg tretmana. [Thesis]. Univerzitet u Beogradu; 2020. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:21066/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Ba Alawi, Wail. Novel Methods for Drug-Target Interaction Prediction using Graph Mining.

Degree: Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division, 2016, King Abdullah University of Science and Technology

URL: http://hdl.handle.net/10754/619165

► The problem of developing drugs that can be used to cure diseases is important and requires a careful approach. Since pursuing the wrong candidate drug… (more)

▼ The problem of developing drugs that can be used to cure diseases is important and requires a careful approach. Since pursuing the wrong candidate drug for a particular disease could be very costly in terms of time and money, there is a strong interest in minimizing such risks. Drug repositioning has become a hot topic of research, as it helps reduce these risks significantly at the early stages of drug development by reusing an approved drug for the treatment of a different disease. Still, finding new usage for a drug is non-trivial, as it is necessary to find out strong supporting evidence that the proposed new uses of drugs are plausible. Many computational approaches were developed to narrow the list of possible candidate drug-target interactions (DTIs) before any experiments are done. However, many of these approaches suffer from unacceptable levels of false positives. We developed two novel methods based on graph mining networks of drugs and targets. The first method (DASPfind) finds all non-cyclic paths that connect a drug and a target, and using a function that we define, calculates a score from all the paths. This score describes our confidence that DTI is correct. We show that DASPfind significantly outperforms other state-of-the-art methods in predicting the top ranked target for each drug. We demonstrate the utility of DASPfind by predicting 15 novel DTIs over a set of ion channel proteins, and confirming 12 out of these 15 DTIs through experimental evidence reported in literature and online drug databases. The second method (DASPfind+) modifies DASPfind in order to increase the confidence and reliability of the resultant predictions. Based on the structure of the drug-target interaction (DTI) networks, we introduced an optimization scheme that incrementally alters the network structure locally for each drug to achieve more robust top 1 ranked predictions. Moreover, we explored effects of several similarity measures between the targets on the prediction accuracy and proposed an enhanced strategy for DTI prediction. Our results show significant improvements of the accuracy of the top ranked DTI prediction over the current state-of-the-art methods. Advisors/Committee Members: Bajic, Vladimir B. (advisor), Kalnis, Panos (committee member), Arold, Stefan T. (committee member), Hide, Winston (committee member).

Subjects/Keywords: graph inference; drug repositioning; Bioinformatics

…use of similar docking methods in identifying DTIs, and in drug repositioning. The drawback… …repositioning. Drug repositioning aims at finding new ! 15! usages for existing drugs that can… …developed. One of the advantages of drug repositioning is that we have wealth of information about… …alawi W, Soufan O, Essak M, Kalnis P, Bajic V. “DASPfind: New Efficient Method to Predict Drug… …36! where p={p1, p2,..., pn} is the set of the paths connecting a specific drug…

12 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ba Alawi, W. (2016). Novel Methods for Drug-Target Interaction Prediction using Graph Mining. (Thesis). King Abdullah University of Science and Technology. Retrieved from http://hdl.handle.net/10754/619165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ba Alawi, Wail. “Novel Methods for Drug-Target Interaction Prediction using Graph Mining.” 2016. Thesis, King Abdullah University of Science and Technology. Accessed March 03, 2021. http://hdl.handle.net/10754/619165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ba Alawi, Wail. “Novel Methods for Drug-Target Interaction Prediction using Graph Mining.” 2016. Web. 03 Mar 2021.

Vancouver:

Ba Alawi W. Novel Methods for Drug-Target Interaction Prediction using Graph Mining. [Internet] [Thesis]. King Abdullah University of Science and Technology; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10754/619165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ba Alawi W. Novel Methods for Drug-Target Interaction Prediction using Graph Mining. [Thesis]. King Abdullah University of Science and Technology; 2016. Available from: http://hdl.handle.net/10754/619165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations