subject:(Tuberculin)

University of Pretoria

1. [No author]. Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique .

Degree: 2010, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-03022010-153428/

► This study was conducted to confirm the presence of bovine tuberculosis (BTB) and determine its prevalence, based on skin test reactivity, in cattle reared under… (more)

▼ This study was conducted to confirm the presence of bovine tuberculosis (BTB) and determine its prevalence, based on skin test reactivity, in cattle reared under extensive farming conditions in the Govuro district, Inhambane province, Mozambique. The study was comprised of a primary screening test using the single intradermal test (SIT) in randomly selected animals from Colonato and Sede dip tanks in Govuro. Positive reactors to the SIT were tested again with bovine and avian tuberculin using the single intradermal comparative test (SICTT) 7 weeks after the SIT. The sample size was calculated using Win Episcope 2.0 based on 95% confidence to detect a 2% expected prevalence using the SIT, with a 1% accepted error and accounting for a total population size of 7208. The calculated sample size was 682 animals. To compensate for the probability of 20% default in reading, the sample size was increased to 853. During the testing process (SIT), it was evident from the first 3 reading days that the apparent prevalence (61, 94%) was higher than expected (2%), hence we decided to stop when the total number of cattle was 530. During the testing process (SIT), it was evident from the first 3 reading days that the apparent prevalence (61.94%) was far higher than expected (2%), hence we decided to stop when the total number of cattle was 530. This was due to the fact that, at such a high prevalence, it would not be necessary to achieve as high a precision as 1% accepted error. A sample size of 530 would be sufficient to achieve a precision of 4% accepted error, which was regarded as more than adequate. The 530 cattle, 3 or more years of age, were selected using systematic random sampling from the two dip tanks (Colonato 371 and Sede 159 animals). All animals were identified by numbers painted, dorsally on the sacral region. Out of 530 tested cattle by SIT, 268 were read, and 166/268 (61.94% with 95% confidence interval [CI]: 55.8 – 67.8%) were found positive, with visible swallow at the injection site. Apparent prevalence (AP) was found to be 61.94% while the true prevalence (TP) was 75.92%. The predictive value of a positive result (PV+) was found to be 87.9%. No significant difference in apparent prevalence between the two areas was detected by Fisher’s exact test (P = 0.11). By SICTT, out of 28 animals positive reactors to SIT, 21 were possible to read, and 13/21 (61.9%; 95% CI: 55.1 – 89.3%) were found positive. A three year old bull, positive reactor to the SIT, was slaughtered, and a detailed post mortem was carried out and organs with visible lesions were collected for further laboratory testing (histopathology, culture and isolation of M. Bovis and PCR). Later on, 30 more positive reactors to the SIT test were slaughtered: 25/30 (83.3%) showed visible lesions compatible with BTB, and total condemnation of carcass was made in 3/25 (12%) due to generalized lesions. The high prevalence rate of skin test positive animals as well as gross lesions and histopathology were confirmed to be BTB by the isolation and identification of… Advisors/Committee Members: Prof J Godfroid (advisor), Prof P N Thompson (advisor), Dr A Machado (advisor).

Subjects/Keywords: BTB; Cattle – Diseases; Mozambique; Bovine tuberculosis; Avian tuberculin; UCTD

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APA (6^th Edition):

author], [. (2010). Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-03022010-153428/

Chicago Manual of Style (16^th Edition):

author], [No. “Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique .” 2010. Masters Thesis, University of Pretoria. Accessed February 27, 2021. http://upetd.up.ac.za/thesis/available/etd-03022010-153428/.

MLA Handbook (7^th Edition):

author], [No. “Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique .” 2010. Web. 27 Feb 2021.

Vancouver:

author] [. Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique . [Internet] [Masters thesis]. University of Pretoria; 2010. [cited 2021 Feb 27]. Available from: http://upetd.up.ac.za/thesis/available/etd-03022010-153428/.

Council of Science Editors:

author] [. Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique . [Masters Thesis]. University of Pretoria; 2010. Available from: http://upetd.up.ac.za/thesis/available/etd-03022010-153428/

2. Almeida, Carlos Augusto Scacchetti de. Avaliação do Teste Cervical Comparativo no diagnóstico imunoalérgico da tuberculose em caprinos (Capra hircus).

Degree: Mestrado, Epidemiologia Experimental Aplicada às Zoonoses, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22042009-080605/ ;

►

O crescimento da caprinocultura no Brasil e a necessidade de controle sanitário dessas criações justificam o estudo de avaliação do teste tuberculinico na espécie caprina.… (more)

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O crescimento da caprinocultura no Brasil e a necessidade de controle sanitário dessas criações justificam o estudo de avaliação do teste tuberculinico na espécie caprina. Utilizando os parâmetros de Silva et al. (2006) foram avaliados 600 caprinos procedentes dos Estados de Minas Gerais, Paraná, Pernambuco, Paraíba e São Paulo. Baseados nos valores do Teste Cervical Comparativo (TCC) 60 animais foram selecionados e submetidos a exame clínico, eutanásia e colheita de material para exames microbiológicos, histopatológicos e moleculares. Dos 36 caprinos positivos, 27 (72%) resultaram em isolamento de micobactérias tipificadas como sendo do complexo M. tuberculosis. Foram identificados focos de tuberculose em caprinos nos Estados de São Paulo, Minas Gerais e Paraíba. Além do isolamento de micobactérias do complexo M. tuberculosis, foram identificados em alguns animais outras bactérias como M. kansasii, M. flavescens, M. avium, complexo M. florentinum M. lentiflavum M. simiae, Corynebacterium pseudotuberculosis e C. bovis. Em um caso houve o isolamento de C. bovis concomitante com micobactéria do complexo M. tuberculosis. As lesões macroscópicas e histopatológicas não diferenciaram a infecção provocada por C. bovis. ou por micobactéria do complexo M. tuberculosis. Os resultados bacteriológicos, histopatológicos e de identificação genética validam a utilização do padrão de interpretação de Silva et al. (2006) no TCC para o diagnóstico da tuberculose em caprinos.

The development of farming goats in Brazil, and the need of sanitary control of these flocks, justify the study of tuberculin test evaluation in goats. Using cut-off points established by Silva et al. (2006), 600 goats from Minas Gerais, Paraná, Pernambuco, Paraíba and São Paulo states were evaluated. According to Comparative Cervical Test values, 60 goats were selected, and submitted to clinical exams, euthanized and materials collected for microbiologycal, histopathologycal and genetic typing. Out of the 36 positive goats, 27 (72%) had isolation of micobacteria classified like Mycobaterium tuberculosis complex. Focus of tuberculosis were identified in São Paulo, Minas Gerais and Paraíba states. Besides isolation of the M. tuberculosis complex micobacteria, other bacterias like M. kansasii, M. flavescens, M. avium, M. florentinum lentiflavum simiae complex, Corynebacterium pseudotuberculosis and C. bovis were identified in some animals. In one case, isolation of C. bovis occurred together with micobacteria of the M. tuberculosis complex. The macroscopic and histopathological lesions did not discriminate infection for C. bovis or of the M. tuberculosis complex micobateria. The bacteriological, histopathological and genetic typing results validate the use of cut-off points established by Silva et al. (2006), in the Cervical Comparative Test for diagnosis of tuberculosis in goats.

Advisors/Committee Members: Pinheiro, Sonia Regina.

Subjects/Keywords: Caprinos; Diagnosis; Diagnóstico; Goats; Tuberculin; Tuberculina; Tuberculose; Tuberculosis

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APA (6^th Edition):

Almeida, C. A. S. d. (2009). Avaliação do Teste Cervical Comparativo no diagnóstico imunoalérgico da tuberculose em caprinos (Capra hircus). (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22042009-080605/ ;

Chicago Manual of Style (16^th Edition):

Almeida, Carlos Augusto Scacchetti de. “Avaliação do Teste Cervical Comparativo no diagnóstico imunoalérgico da tuberculose em caprinos (Capra hircus).” 2009. Masters Thesis, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22042009-080605/ ;.

MLA Handbook (7^th Edition):

Almeida, Carlos Augusto Scacchetti de. “Avaliação do Teste Cervical Comparativo no diagnóstico imunoalérgico da tuberculose em caprinos (Capra hircus).” 2009. Web. 27 Feb 2021.

Vancouver:

Almeida CASd. Avaliação do Teste Cervical Comparativo no diagnóstico imunoalérgico da tuberculose em caprinos (Capra hircus). [Internet] [Masters thesis]. University of São Paulo; 2009. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22042009-080605/ ;.

Council of Science Editors:

Almeida CASd. Avaliação do Teste Cervical Comparativo no diagnóstico imunoalérgico da tuberculose em caprinos (Capra hircus). [Masters Thesis]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22042009-080605/ ;

Stellenbosch University

3. Clarke, Charlene. Investigation of temporal changes in immune responses to Mycobacterium bovis in cattle and African buffaloes (Syncerus caffer).

Degree: MSc, Biomedical Sciences, 2017, Stellenbosch University

URL: http://hdl.handle.net/10019.1/101356

► ENGLISH ABSTRACT: Cattle and African buffaloes are major maintenance hosts of Mycobacterium bovis in South Africa and therefore serve as a potential source of infection… (more)

▼ ENGLISH ABSTRACT: Cattle and African buffaloes are major maintenance hosts of Mycobacterium bovis in South Africa and therefore serve as a potential source of infection for other animals and humans. Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB). Identification and removal of M. bovis-infected animals from the herd at early stages of infection is important for effective disease management and relies on the strategic application of ante-mortem diagnostic tests. Ante-mortem diagnostic tests rely on the detection of specific immunological responses in the animal. However, these responses vary over the course of infection and therefore the accuracy of the diagnostic test may change, depending on the stage of infection. We therefore aimed to investigate the temporal changes in antigen-specific cytokine production and humoral responses to BTB in buffaloes. Interferon-gamma (IFN-ɣ) and IFN-ɣ-induced protein 10 (IP-10) production in response to mycobacterial antigens ESAT-6/CFP-10, and serum antibodies to bovine purified protein derivative (bPPD) were measured in a group of chronically test-positive, newly converted test-positive and test-negative buffaloes over one year. No consistent trends in immune responses over time were observed in any of the groups. Cytokine release assays (CRAs) are often used in conjunction with the tuberculin skin test (TST) to improve diagnostic performance. However, many studies have shown that the TST may influence IFN-ɣ production and thereby the outcome of immunodiagnostic tests in cattle. However, these results were conflicting. A better understanding of the influence of the TST on cytokine production and the duration of this effect in a South African situation is required. We therefore aimed to investigate if the TST has an influence on IFN-ɣ and IP-10 production and test outcome in cattle and African buffaloes. IFN-ɣ and IP-10 release were measured in response to bPPD, avian PPD, ESAT-6 and CFP-10 in groups of TST-positive cattle 6, 7, 21, 41 and 78 days post-TST and in a group of TST-negative cattle 7, 21 and 78 days post-TST. IFN-ɣ and IP-10 levels in response to PPD were elevated 1-3 weeks post-TST, followed by a decrease by 41 days, suggesting immune boosting by the TST. ESAT-6/CFP-10-specific cytokine release showed conflicting results, with a group of animals showing decreased cytokine production by 41 days, whereas another group showed no change in cytokine release over time. Our findings suggest that cattle should not be tested with CRAs between 6 and 41 days post-TST to avoid boosting of cytokine levels and inaccurate test results. IFN-ɣ and IP-10 release in response to PC-EC®, PC-HP®, bPPD and avian PPD were measured in a group of Bovigam®-positive and negative buffaloes at the time the TST was performed and three days later. In Bovigam®-positive buffaloes a significant decrease in cytokine production and in the proportion of test positive animals were observed three days post-TST in response to all antigens, except aPPD. Bovigam®-negative animals were… Advisors/Committee Members: Miller, Michele Ann, Parsons, Sven David Charles, Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Biomedical Sciences: Molecular Biology and Human Genetics..

Subjects/Keywords: Mycobacterium bovis; African buffalo; Tuberculin test; Interferon gamma; UCTD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clarke, C. (2017). Investigation of temporal changes in immune responses to Mycobacterium bovis in cattle and African buffaloes (Syncerus caffer). (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/101356

Chicago Manual of Style (16^th Edition):

Clarke, Charlene. “Investigation of temporal changes in immune responses to Mycobacterium bovis in cattle and African buffaloes (Syncerus caffer).” 2017. Masters Thesis, Stellenbosch University. Accessed February 27, 2021. http://hdl.handle.net/10019.1/101356.

MLA Handbook (7^th Edition):

Clarke, Charlene. “Investigation of temporal changes in immune responses to Mycobacterium bovis in cattle and African buffaloes (Syncerus caffer).” 2017. Web. 27 Feb 2021.

Vancouver:

Clarke C. Investigation of temporal changes in immune responses to Mycobacterium bovis in cattle and African buffaloes (Syncerus caffer). [Internet] [Masters thesis]. Stellenbosch University; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10019.1/101356.

Council of Science Editors:

Clarke C. Investigation of temporal changes in immune responses to Mycobacterium bovis in cattle and African buffaloes (Syncerus caffer). [Masters Thesis]. Stellenbosch University; 2017. Available from: http://hdl.handle.net/10019.1/101356

4. SILVA NETO, Francisco Bernardino da. Teste tuberculínio no diagnóstico da infecção latente pelo Mycobacterium tuberculosis em pessoas vivendo com HIV/AIDS em um hospital de referência no Estado da Paraíba .

Degree: 2015, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/17702

► O diagnóstico e o tratamento da infecção latente pelo Mycobacterium tuberculosis (ILTB) são indicados para grupos nos quais a prevalência da infecção latente é alta,… (more)

▼ O diagnóstico e o tratamento da infecção latente pelo Mycobacterium tuberculosis (ILTB) são indicados para grupos nos quais a prevalência da infecção latente é alta, em contactantes de casos novos de tuberculose (TB) e quando o risco de reativação é alto como em pessoas vivendo com HIV/AIDS (PVHA). Tanto o vírus da imunodeficiência humana (HIV) facilita a reativação da ILTB quanto o Mycobacterium tuberculosis contribui para a progressão da doença pelo HIV. O conhecimento acerca do diagnóstico e do tratamento da ILTB em PVHA torna-se fundamental visto que o Relatório Global de Controle da Tuberculose da Organização Mundial da Saúde (OMS) indica que as PVHA estão 26 a 31 vezes mais propensas a desenvolver TB ativa quando comparadas à população geral. Além disso, a taxa de letalidade da TB em PVHA é 3 vezes maior do que a observada na população geral. Apesar de suas limitações, o teste tuberculínico (TT) continua sendo a principal ferramenta de diagnóstico da ILTB, entretanto, isso não parece refletir no número de TT solicitados e realizados e, consequentemente, no número de tratamentos prescritos para ILTB. No Brasil, e em particular na Paraíba, os dados sobre a solicitação e realização do TT e acerca da prescrição do tratamento para ILTB são pouco conhecidos. Esse estudo objetivou verificar a frequência de solicitação e de realização (inoculação do derivado protéico purificado (PPD) e leitura) do TT, a frequência de TT reator e a frequência da prescrição do tratamento para ILTB e caracterizar as PVHA atendidas em serviço de referência em HIV/AIDS e TB no estado da Paraíba quanto a aspectos sociodemográficos e laboratoriais, no período de janeiro de 2009 a dezembro de 2013. Para obtenção dos dados, utilizou-se formulário padronizado, preenchido, retrospectivamente, a partir das informações contidas na primeira consulta registrada nos prontuários dos pacientes atendidos no período do estudo. Dos 3.191 pacientes incluídos na pesquisa, 2.303 (72,2%) tiveram o TT solicitado. Destes, 2.047 (89,0%) foram submetidos a realização do TT que compreendeu a inoculação do PPD e a leitura da induração. Dos 2.047 pacientes que tiveram o PPD inoculado e submetidos a leitura da induração, 90 (4,4%) pacientes tiveram o TT reator sendo o tratamento para ILTB prescrito para todos. Os resultados da pesquisa sugerem que há uma excelente adesão à solicitação do TT e à prescrição do tratamento para ILTB entre os profissionais médicos e baixa prevalência de ILTB no local do estudo. Outrossim, acessibilidade adequada para realização e boa compreensão por parte dos pacientes quanto a sua importância no contexto da atenção à saúde das PVHA garantiram a frequência elevada de realização do TT. Advisors/Committee Members: SILVEIRA, Vera Magalhães da (advisor), MOURA, Líbia Cristina Rocha Vilela (advisor), http://lattes.cnpq.br/1262842713515748 (advisor).

Subjects/Keywords: Teste tuberculínico; Tuberculose latente; HIV; Tuberculin test; Latent tuberculosis; HIV

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APA (6^th Edition):

SILVA NETO, F. B. d. (2015). Teste tuberculínio no diagnóstico da infecção latente pelo Mycobacterium tuberculosis em pessoas vivendo com HIV/AIDS em um hospital de referência no Estado da Paraíba . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/17702

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SILVA NETO, Francisco Bernardino da. “Teste tuberculínio no diagnóstico da infecção latente pelo Mycobacterium tuberculosis em pessoas vivendo com HIV/AIDS em um hospital de referência no Estado da Paraíba .” 2015. Thesis, Universidade Federal de Pernambuco. Accessed February 27, 2021. http://repositorio.ufpe.br/handle/123456789/17702.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SILVA NETO, Francisco Bernardino da. “Teste tuberculínio no diagnóstico da infecção latente pelo Mycobacterium tuberculosis em pessoas vivendo com HIV/AIDS em um hospital de referência no Estado da Paraíba .” 2015. Web. 27 Feb 2021.

Vancouver:

SILVA NETO FBd. Teste tuberculínio no diagnóstico da infecção latente pelo Mycobacterium tuberculosis em pessoas vivendo com HIV/AIDS em um hospital de referência no Estado da Paraíba . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2015. [cited 2021 Feb 27]. Available from: http://repositorio.ufpe.br/handle/123456789/17702.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SILVA NETO FBd. Teste tuberculínio no diagnóstico da infecção latente pelo Mycobacterium tuberculosis em pessoas vivendo com HIV/AIDS em um hospital de referência no Estado da Paraíba . [Thesis]. Universidade Federal de Pernambuco; 2015. Available from: http://repositorio.ufpe.br/handle/123456789/17702

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Massey University

5. Chen, Shuxiong. Design and engineering of self-assembling antigens towards particulate vaccines.

Degree: PhD, Microbiology, 2019, Massey University

URL: http://hdl.handle.net/10179/15729

► Natural and synthetic self-assembling polymers and proteins could be bioengineered to display and/or encapsulate antigens to serve as innovative antigen carrier systems for the induction… (more)

▼ Natural and synthetic self-assembling polymers and proteins could be bioengineered to display and/or encapsulate antigens to serve as innovative antigen carrier systems for the induction of desirable immunities. Polyhydroxyalkanoates (PHAs) are naturally occurring polyesters synthesized as cytoplasmic polyester inclusions (polyester particles) by various bacteria. The particles have been used as an antigen delivery platform by translationally fusing antigens to the particle surface-associated protein, PHA synthase. Furthermore, it has been found that protein inclusion bodies contain a large amount of correctly folded and biologically active proteins and could be engineered to perform as an antigen carrier system. Tuberculosis (TB) is a global health issue for both humans and animals. Inaccurate diagnosis and inefficacious vaccination make TB control problematic. The Mantoux tuberculin skin test gives false positive results if humans or animals are vaccinated with the Bacille Calmette-Guérin (BCG) strain or exposed to environmental mycobacteria. BCG cannot provide effective protection against TB. Subunit vaccines have great promise to protect against infectious diseases, but they are often weak immunogenically. A strategy to circumvent this problem is the use of self-assembly particulate vaccines, which could present multiple copies of antigens and serve as a depot for prolonged multivalent antigen display to induce enhanced immunogenicity. In this thesis, four specific TB diagnostic antigens — CFP10, Rv3615c, ESAT6, and Rv3020c — were displayed on polyester particles. The results showed that polyester particles displaying TB antigens specifically distinguished TB-infected from non-infected cattle. Antigen immunogenicity was dramatically enhanced after the display on polyester particles, which lowered the antigen concentration (0.1 to 3 μg dose/inoculum) required for skin tests. Mycobacterial vaccines H4 (Ag85B-TB10.4) or H28 (Ag85B-TB10.4-Rv2660c) were bioengineered to display H4/H28 on polyester particles and/or self-assemble H4/H28 into protein inclusion bodies. The results demonstrated that polyester particle-/protein inclusion body-based particulate TB vaccines increased overall immunogenicity by enhancing humoral (for example, IgG1 and IgG2c) and cellular (for example, IFNγ and IL17A) immune responses when compared to respective soluble antigens.

Subjects/Keywords: Tuberculosis vaccines; Biotechnology; Tuberculin test; Immunological adjuvants; Antigens; Tuberculosis in cattle

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, S. (2019). Design and engineering of self-assembling antigens towards particulate vaccines. (Doctoral Dissertation). Massey University. Retrieved from http://hdl.handle.net/10179/15729

Chicago Manual of Style (16^th Edition):

Chen, Shuxiong. “Design and engineering of self-assembling antigens towards particulate vaccines.” 2019. Doctoral Dissertation, Massey University. Accessed February 27, 2021. http://hdl.handle.net/10179/15729.

MLA Handbook (7^th Edition):

Chen, Shuxiong. “Design and engineering of self-assembling antigens towards particulate vaccines.” 2019. Web. 27 Feb 2021.

Vancouver:

Chen S. Design and engineering of self-assembling antigens towards particulate vaccines. [Internet] [Doctoral dissertation]. Massey University; 2019. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10179/15729.

Council of Science Editors:

Chen S. Design and engineering of self-assembling antigens towards particulate vaccines. [Doctoral Dissertation]. Massey University; 2019. Available from: http://hdl.handle.net/10179/15729

6. Helaine Cristina Alves Vasconcelos. PrevalÃncia de tuberculose infecÃÃo entre profissionais que trabalham em hospital municipal de emergÃncia em Fortaleza-CearÃ.

Degree: Master, 2015, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15205 ;

►

Os profissionais que prestam cuidados assistenciais em saÃde constituem populaÃÃo de risco para tuberculose (TB) infecÃÃo. O teste tuberculÃnico (TT) desempenha um importante papel no… (more)

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Os profissionais que prestam cuidados assistenciais em saÃde constituem populaÃÃo de risco para tuberculose (TB) infecÃÃo. O teste tuberculÃnico (TT) desempenha um importante papel no controle epidemiolÃgico da doenÃa, identificando indivÃduos com maior risco de desenvolvÃ-la. Estudo transversal que objetivou investigar a ocorrÃncia de TB infecÃÃo entre profissionais que trabalhavam no Instituto Doutor JosÃ Frota (IJF) entre os meses de outubro e dezembro de 2014 e o nÃvel de conhecimento que apresentavam sobre tuberculose. Os setores da instituiÃÃo hospitalar classificados pelo serviÃo de medicina do trabalho quanto Ã presenÃa ou ausÃncia do risco biolÃgico foram agrupados quanto Ã presenÃa ou ausÃncia do risco de exposiÃÃo profissional a M. tuberculosis e logo apÃs, sorteados aleatoriamente dentre de cada grupo de risco. Aplicou-se um questionÃrio semi-estruturado e o TT. Foram avaliados 220 profissionais, sendo 151 (68,6%) de setores assistenciais e 69 (31,4%) de administrativos. Houve predominÃncia do sexo feminino (80,9%), com mediana de idade de 45 anos, moravam na capital (54,1%), com familiares (90,5%), possuÃam cÃnjuge (72,7%), nÃvel de escolaridade mÃdio (46,9%) e que nunca fumaram (77,7%) ou ingeriram bebidas alcoÃlicas (56,8%). A prevalÃncia de infecÃÃo por TB, foi de 47,3% e a presenÃa do efeito booster foi identificada em 8% dos profissionais de saÃde que trabalhavam em setores de risco, sendo 3 (1,4%) enfermeiras, 3 (1,4%) tÃcnicas de enfermagem e 1 (0,5%) psicÃloga. Os setores classificados como risco de exposiÃÃo profissional a M. tuberculosis, onde foi localizada a maior quantidade de profissionais com resultados positivos foram Centro CirÃrgico (n=18; 8,2%), EmergÃncia (n=12; 5,5%) e Traumatologia (n=11; 5%). JÃ dentre aqueles classificados como sem risco, foram encontrados profissionais com teste positivo na Biblioteca e AuditÃrios (n=3; 1,4%), seguido por Almoxarifado Central, Procuradoria JurÃdica e NÃcleo de Pessoal, onde cada setor apresentou dois indivÃduos, totalizando seis. A Ãrea de enfermagem foi a de maior positividade: 28 (12,7%) tÃcnicos de enfermagem, 23 (10,4%) auxiliares de enfermagem e 8 (3,6%) enfermeiras, obtiveram diÃmetros de teste que variaram entre 10mm e 25mm. A presenÃa de TB infecÃÃo esteve estatisticamente associada com a escolaridade (p=0,017), renda individual (p=0,028) e nÃvel da categoria profissional (p=0,028). A avaliaÃÃo do conhecimento sobre TB revelou que somente 3,2% dos profissionais que trabalhavam na EmergÃncia possuÃam conhecimento suficiente sobre o assunto. Os tÃpicos onde houve o maior nÃmero de acertos foram os que abordavam sobre caracterÃsticas gerais da infecÃÃo e transmissÃo por TB. Pode-se concluir que a prevalÃncia de infecÃÃo por TB nos profissionais que trabalhavam no IJF foi considerada alta e o conhecimento que os mesmos tÃm sobre tuberculose mostrou-se insatisfatÃrio

Professionals who provide health care assistance are a risk population for tuberculosis (TB) infection. The tuberculin skin test (TST) plays an important role in the…

Advisors/Committee Members: MÃnica Cardoso FaÃanha, Paulo CÃsar de Almeida, ValÃria GÃes Ferreira Pinheiro.

Subjects/Keywords: SAUDE COLETIVA; Tuberculose Latente; Teste TuberculÃnico; SaÃde do Trabalhador; Latent Tuberculosis; Tuberculin Test; Occupational Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vasconcelos, H. C. A. (2015). PrevalÃncia de tuberculose infecÃÃo entre profissionais que trabalham em hospital municipal de emergÃncia em Fortaleza-CearÃ. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15205 ;

Chicago Manual of Style (16^th Edition):

Vasconcelos, Helaine Cristina Alves. “PrevalÃncia de tuberculose infecÃÃo entre profissionais que trabalham em hospital municipal de emergÃncia em Fortaleza-CearÃ.” 2015. Masters Thesis, Universidade Federal do Ceará. Accessed February 27, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15205 ;.

MLA Handbook (7^th Edition):

Vasconcelos, Helaine Cristina Alves. “PrevalÃncia de tuberculose infecÃÃo entre profissionais que trabalham em hospital municipal de emergÃncia em Fortaleza-CearÃ.” 2015. Web. 27 Feb 2021.

Vancouver:

Vasconcelos HCA. PrevalÃncia de tuberculose infecÃÃo entre profissionais que trabalham em hospital municipal de emergÃncia em Fortaleza-CearÃ. [Internet] [Masters thesis]. Universidade Federal do Ceará 2015. [cited 2021 Feb 27]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15205 ;.

Council of Science Editors:

Vasconcelos HCA. PrevalÃncia de tuberculose infecÃÃo entre profissionais que trabalham em hospital municipal de emergÃncia em Fortaleza-CearÃ. [Masters Thesis]. Universidade Federal do Ceará 2015. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15205 ;

7. Bolaños, Carmen Alicia Daza [UNESP]. Isolamento microbiológico e caracterização molecular de micobactérias no leite de vacas positivas no teste de tuberculinização cervical comparativo.

Degree: 2016, Universidade Estadual Paulista

URL: http://hdl.handle.net/11449/145018

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A tuberculose, causada por Mycobacterium bovis, permanece como uma das principais doenças infecciosas de bovinos, em virtude dos prejuízos causados com a redução na produção… (more)

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A tuberculose, causada por Mycobacterium bovis, permanece como uma das principais doenças infecciosas de bovinos, em virtude dos prejuízos causados com a redução na produção de carne e leite, condenação de carcaças em abatedouros e embargos na comercialização de animais e produtos de origem animal, bem como pelo potencial zoonótico do patógeno, particularmente pela eliminação pelo leite. Ademais, micobactérias não tuberculosas ou atípicas são causa emergente de doenças em humanos e em animais. Apesar de a tuberculinização representar o principal teste diagnóstico “in vivo” da doença em rebanhos, poucos estudos têm avaliado a eliminação de micobactérias pelo leite em vacas positivas nos testes intradérmicos. O objetivo do presente estudo foi identificar espécies de Mycobacterium em amostras de leite de vacas positivas no teste de tuberculinização cervical comparativo. Um “pool” do leite dos quartos de 142 (2,97%) vacas positivas - proveniente de 4.766 animais tuberculinizados - foi coletado assepticamente e cultivado em condições de aerobiose a 37 °C nos meios de Lowestein-Jensen e Stonebrink, mantidos por até 90 dias. Colônias compatíveis com micobactérias foram submetidas à coloração de Ziehl-Neelsen para o diagnóstico de bacilos álcool-ácido resistentes (BAAR) e detecção molecular. Catorze estirpes isoladas em 12 amostras (n=12/142, 8.4%) foram classificadas pela técnica de reação em cadeia da polimerase com enzimas de restrição (PCR-PRA) e sequenciamento como segue: M. mucogenicum tipo 2 (n=4), M. nonchromogenicum tipo 1 (n=3), M. hodleri type 1 (n=2), M. terrae tipo 3 (n=3), M. cookii tipo 1 (n=1), e M. szulgai tipo 1 (n=1). O sequenciamento do gene hsp65 revelou >98% de similaridade com as espécies de micobactérias depositadas no GeneBank, e detectou: M. engbaekii (n=5), M. arupense (n=4), M. nonchromogenicum (n=3) e M. heraklionense (n=2). Houve concordância na detecção das espécies de micobactérias entre PCR-PRA e sequenciamento em três dos isolados, exclusivamente da espécie M. nonchromogenicum (n=3/14; 21.4%). Árvore filogenética e dendograma (baseado no gene hsp65) dos 14 isolados revelou 4 clusters e 3 subclusters (79,0% de similaridade), respectivamente, e classificou os isolados como micobactérias atípicas agrupados no complexo M. terrae. Apesar da ausência de espécies do complexo M. tuberculosis nas amostras cultivadas, a presença de micobactérias atípicas, alerta para o risco de transmissão do patógeno pelo leite ou derivados para os humanos, visto que muitas dessas espécies de micobactérias já foram descritas causando infecções pulmonares e extrapulmonares em humanos imunocompetentes e imunossuprimidos

Tuberculosis caused by Mycobacterium bovis remains as one of the major infectious diseases of cattle, due to losses caused by the reduction in the meat and milk yield, condemnation of carcasses in slaughterhouses, and embargoes on the trade of bovine products, as well as the zoonotic potential of pathogen particularly by elimination in milk. In addition, nontuberculous or atypical mycobacteria…

Advisors/Committee Members: Ribeiro, Márcio Garcia [UNESP], Universidade Estadual Paulista (UNESP).

Subjects/Keywords: Mycobacterium; Bovino; Alergodiagnóstico; PCR-PRA; Sequenciamento; Mycobacterium; Bovine; Tuberculin skin test; PCR-PRA; Sequencing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bolaños, C. A. D. [. (2016). Isolamento microbiológico e caracterização molecular de micobactérias no leite de vacas positivas no teste de tuberculinização cervical comparativo. (Thesis). Universidade Estadual Paulista. Retrieved from http://hdl.handle.net/11449/145018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bolaños, Carmen Alicia Daza [UNESP]. “Isolamento microbiológico e caracterização molecular de micobactérias no leite de vacas positivas no teste de tuberculinização cervical comparativo.” 2016. Thesis, Universidade Estadual Paulista. Accessed February 27, 2021. http://hdl.handle.net/11449/145018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bolaños, Carmen Alicia Daza [UNESP]. “Isolamento microbiológico e caracterização molecular de micobactérias no leite de vacas positivas no teste de tuberculinização cervical comparativo.” 2016. Web. 27 Feb 2021.

Vancouver:

Bolaños CAD[. Isolamento microbiológico e caracterização molecular de micobactérias no leite de vacas positivas no teste de tuberculinização cervical comparativo. [Internet] [Thesis]. Universidade Estadual Paulista; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11449/145018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bolaños CAD[. Isolamento microbiológico e caracterização molecular de micobactérias no leite de vacas positivas no teste de tuberculinização cervical comparativo. [Thesis]. Universidade Estadual Paulista; 2016. Available from: http://hdl.handle.net/11449/145018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Gupta, Deepak Kumar. BCG, Tuberculin skin-test result and asthma in children; -.

Degree: Medicine, 2007, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/10772

None

Summary p. 55-56, References p. 59-71, Appendix included

Advisors/Committee Members: Lalit Kumar.

Subjects/Keywords: Medical Sciences; Paediatrics; BCG; Asthma; Tuberculin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gupta, D. K. (2007). BCG, Tuberculin skin-test result and asthma in children; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10772

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gupta, Deepak Kumar. “BCG, Tuberculin skin-test result and asthma in children; -.” 2007. Thesis, Bundelkhand University. Accessed February 27, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/10772.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gupta, Deepak Kumar. “BCG, Tuberculin skin-test result and asthma in children; -.” 2007. Web. 27 Feb 2021.

Vancouver:

Gupta DK. BCG, Tuberculin skin-test result and asthma in children; -. [Internet] [Thesis]. Bundelkhand University; 2007. [cited 2021 Feb 27]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10772.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gupta DK. BCG, Tuberculin skin-test result and asthma in children; -. [Thesis]. Bundelkhand University; 2007. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10772

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Mariana Assunção de Souza. Tuberculose bovina: diagnóstico intradérmico e exames complementares em propriedade de exploração leiteira.

Degree: 2013, Federal University of Uberlândia

URL: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4925

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O objetivo deste trabalho foi avaliar a ocorrência da tuberculose em um plantel bovino pelo teste cervical comparativo (TCC), e analisar a eficiência de exames… (more)

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O objetivo deste trabalho foi avaliar a ocorrência da tuberculose em um plantel bovino pelo teste cervical comparativo (TCC), e analisar a eficiência de exames complementares na confirmação da infecção. O estudo foi realizado em um rebanho de exploração leiteira no município de Perdizes MG. Realizou-se a tuberculinização em 164 bovinos, sendo que destes 40 foram encaminhados ao abate sanitário. A inspeção macroscópica post mortem das carcaças foi acompanhada de colheita de amostras de muco nasal, sangue e tecido (fígado, pulmão e linfonodo mediastínico) para os exames de PCR, ELISA e histopatológico com colorações de Hematoxilina-Eosina (HE) e Ziehl-Neelsen (ZN) respectivamente. Dos 164 bovinos avaliados pelo TCC, 41 (25%) foram positivos, 29 (17,68%) inconclusivos e 94 (57,32%) negativos. Dos 40 bovinos encaminhados para abate, 22 (55%) carcaças apresentaram algum tipo de lesão macroscópica sugestiva de tuberculose, sendo 14 (35%) nos linfonodos mediastínicos, sete (17,5%) no fígado e seis (15%) no pulmão. Nos achados histopatológicos visualizados em HE 13 (32,5%) carcaças apresentaram alterações histológicas, sendo seis (15%) nos linfonodos mediastínicos, cinco (12,5%) no fígado e três (7,5%) no pulmão. Não foi observada a presença de bacilos álcool-ácido resistentes em nenhuma das amostras avaliadas. O ensaio sorológico de ELISA/IDEXX identificou um (2,5%) animal reagente, e o teste de PCR detectou DNA de M. bovis em uma (2,5%) amostra. Por ser um rebanho leiteiro, a ocorrência da tuberculose pode representar um risco zoonótico. O TCC já deveria ser um exame de rotina obrigatório em toda propriedade que comercializa leite ou carne, pois reconhece infecções recentes, muitas vezes não detectadas em exames complementares.

The aim of this study was to evaluate the incidence of tuberculosis in a cattle herd by the cervical comparative intradermal tuberculin test (ITT), and analyze the efficiency of complementary diagnostic methods in confirming the infection. The study was conducted on a breeding dairy farm in the city of Perdizes MG. Tuberculin test was performed in 164 cattle, of which 40 were positive and slaughtered. The macroscopic post mortem inspection of carcasses was followed by the collection of nasal swabs, blood and tissue samples (liver, lung and mediastinal lymph node) for PCR tests, ELISA and histopatology with Hematoxylin-Eosin (HE) and Ziehl-Neelsen (ZN) respectively. Of the 164 cattle analysed by ITT, 41 (25%) were positive, 29 (17.68%) inconclusive and 94 (57.32%) negative. Of the 40 cattle slaughtered, 22 (55%) carcasses had macroscopic lesions suggestive of tuberculosis, 14 (35%) in the mediastinal lymph nodes, seven (17.5%) in the liver and six (15%) in the lung. The histopathology HE identified 13 (32.5%) carcasses with histological changes, six (15%) in the mediastinal lymph nodes, five (12.5%) in the liver and three (7.5%) in the lung. At ZN, the presence of acid-fast bacilli was not detected in any of samples tested. The ELISA/IDEXX identified one (2.5%) animal reagent, and the PCR test…

Advisors/Committee Members: Anna Monteiro Correia Lima Ribeiro, Alessandra Aparecida Medeiros, Eliana Roxo.

Subjects/Keywords: ELISA; Histopatologia; Mycobacterium bovis; PCR; Tuberculina; MEDICINA VETERINARIA; Tuberculose em bovino; Histopathology; Mycobacterium bovis; Tuberculin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, M. A. d. (2013). Tuberculose bovina: diagnóstico intradérmico e exames complementares em propriedade de exploração leiteira. (Thesis). Federal University of Uberlândia. Retrieved from http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4925

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Souza, Mariana Assunção de. “Tuberculose bovina: diagnóstico intradérmico e exames complementares em propriedade de exploração leiteira.” 2013. Thesis, Federal University of Uberlândia. Accessed February 27, 2021. http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4925.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Souza, Mariana Assunção de. “Tuberculose bovina: diagnóstico intradérmico e exames complementares em propriedade de exploração leiteira.” 2013. Web. 27 Feb 2021.

Vancouver:

Souza MAd. Tuberculose bovina: diagnóstico intradérmico e exames complementares em propriedade de exploração leiteira. [Internet] [Thesis]. Federal University of Uberlândia; 2013. [cited 2021 Feb 27]. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4925.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Souza MAd. Tuberculose bovina: diagnóstico intradérmico e exames complementares em propriedade de exploração leiteira. [Thesis]. Federal University of Uberlândia; 2013. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4925

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

10. Roos, Eduard Otto. Detection and Characterization of Mycobacterial Infections Occurring in Phacochoerus africanus (Gmelin, 1788) (Common Warthog).

Degree: PhD, Biomedical Sciences, 2018, Stellenbosch University

URL: http://hdl.handle.net/10019.1/104836

► ENGLISH ABSTRACT: Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex and the cause of bovine tuberculosis (bTB), has an extensive host range that includes… (more)

▼ ENGLISH ABSTRACT: Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex and the cause of bovine tuberculosis (bTB), has an extensive host range that includes livestock and wildlife. While warthogs are considered spill-over hosts for bTB, they could potentially become reservoir hosts, if conditions are favourable, i.e. increased population densities. With limited knowledge on the infection status of warthogs in South Africa and their epidemiological significance for other species, it is imperative to have readily available diagnostic tests for warthogs. Therefore, this study aimed to (i) establish reference cohorts of M. bovis-infected and uninfected warthogs; (ii) utilize these for the development and evaluation of diagnostic tools that can distinguish between infected and uninfected individuals; (iii) determine the seroprevalence of bTB in warthogs using the newly developed diagnostic tools; and (iv) characterize the genetic diversity of M. bovis isolates from warthogs. Three serological assays, i.e. the indirect PPD ELISA, the TB ELISA-VK® and the DPP® VetTB Assay, could distinguish between M. bovis-infected and uninfected warthogs with high sensitivity (75-88%) and specificity (79-89%). The overall seroprevalence from four M. bovis-endemic locations was high, i.e. 38%. Furthermore, three tests measuring the cellmediated immune responses of warthogs were developed. A cytokine release assay measuring interferon gamma induced protein 10 was able to distinguish between M. bovisinfected and uninfected warthog with a sensitivity of 68% and a specificity of 84%. The comparative intradermal tuberculin test classified 100% of culture-negative warthogs as test negative and 81% of culture-positive warthogs as test positive. Lastly, CXCL9, 10, 11, IFNG and TNFA gene expression were significantly increased in whole blood from M. bovis-infected warthogs in response to antigen stimulation, with CXCL10 showing the greatest mean fold increase. High genetic diversity of M. bovis isolates from warthogs was confirmed through spoligotyping and whole genome sequencing. Two distinct clades of M. bovis were identified by WGS, even though they shared the same spoligotype patterns This study has demonstrated that warthogs develop measurable and specific immune responses to M. bovis infection, which can be used to identify infected individuals ante-mortem. Furthermore, these tests will facilitate epidemiological studies of bTB in warthogs. With a high culture prevalence in warthogs from bTB endemic areas such as uMhkuze Nature Reserve and the Greater Kruger National Park, and high seroprevalence, warthogs seem to be highly susceptible to M. bovis infection. This suggests that warthogs may be an ideal sentinel species and strengthens the case that, under certain circumstances, they could be maintenance hosts. The genetic diversity of M. bovis isolates and the identification of two distinct clades challenges the current hypothesis that a single dominant strain circulates within a specific geographical… Advisors/Committee Members: Miller, Michele Ann, Parsons, Sven David Charles, Olea-Popelka, Francisco, Stellenbosch University. Faculty of Medicine and Health Science. Dept. of Biomedical Sciences: Molecular Biology and Human Genetics..

Subjects/Keywords: Intradermal tuberculin test; UCTD; Bovine tuberculosis; Cell-mediated immunity; Mycobacterium bovis; Medical screening; Serodiagnosis; Warthog

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roos, E. O. (2018). Detection and Characterization of Mycobacterial Infections Occurring in Phacochoerus africanus (Gmelin, 1788) (Common Warthog). (Doctoral Dissertation). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/104836

Chicago Manual of Style (16^th Edition):

Roos, Eduard Otto. “Detection and Characterization of Mycobacterial Infections Occurring in Phacochoerus africanus (Gmelin, 1788) (Common Warthog).” 2018. Doctoral Dissertation, Stellenbosch University. Accessed February 27, 2021. http://hdl.handle.net/10019.1/104836.

MLA Handbook (7^th Edition):

Roos, Eduard Otto. “Detection and Characterization of Mycobacterial Infections Occurring in Phacochoerus africanus (Gmelin, 1788) (Common Warthog).” 2018. Web. 27 Feb 2021.

Vancouver:

Roos EO. Detection and Characterization of Mycobacterial Infections Occurring in Phacochoerus africanus (Gmelin, 1788) (Common Warthog). [Internet] [Doctoral dissertation]. Stellenbosch University; 2018. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10019.1/104836.

Council of Science Editors:

Roos EO. Detection and Characterization of Mycobacterial Infections Occurring in Phacochoerus africanus (Gmelin, 1788) (Common Warthog). [Doctoral Dissertation]. Stellenbosch University; 2018. Available from: http://hdl.handle.net/10019.1/104836

Vilnius University

11. Sučilienė, Elena. Skirtingu laiku BCG vakcinomis skiepytų vaikų tuberkulino reakcijos ikimokykliniu laikotarpiu.

Degree: Dissertation, Medicine, 2010, Vilnius University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105347-37189 ;

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Disertacijos objektas: įvairių BCG skiepijimo režimų įtaka tuberkulino reakcijos išraiškai, vietinei BCG žymei, specifinei serologijai, alergijos klinikai vaikams iki 6 m. Tyrime dalyvavo 509 vaikai,… (more)

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Disertacijos objektas: įvairių BCG skiepijimo režimų įtaka tuberkulino reakcijos išraiškai, vietinei BCG žymei, specifinei serologijai, alergijos klinikai vaikams iki 6 m. Tyrime dalyvavo 509 vaikai, vakcinuoti įprasta arba pusine BCG vakcinos doze naujagimio ar 3 mėn. amžiaus. Jiems 3 mėn. po BCG vakcinacijos, 1, 2 ir 6 m. atliktas tuberkulino mėginys, įvertintas BCG randelis, ištirti specifiniai antikūnai kraujo serume, įvertintos alerginės būklės. Disertacijos išvadose konstatuojama, kad 3 mėn. amžiaus BCG vakcinuotų vaikų tuberkulino reakcijos yra stipresnės bei susidariusi vietinė BCG žymė dažnesnė, nei įprasta BCG vakcinos doze naujagimio amžiaus skiepytųjų, tiriant juos 3 mėn. po BCG vakcinacijos ar 1 m. amžiaus. Specifinių antikūnų dėsningumų nepavyko aptikti. 3 mėn. amžiaus kūdikių BCG vakcinacija sumažino su maistu siejamų alerginių bėrimų riziką mergaitėms ikimokykliniu laikotarpiu.

Object of dissertation: The influence of different BCG vaccination schedules on the tuberculin reactivity, BCG scarring, specific serology and allergy. 509 children were included in this research, all of them received BCG vaccination with standard or half dosage as newborns or 3-months old. 3 months after BCG vaccination and at one, two, and six years of age they were tested with tuberculin, and examined for BCG scarring. Anti-tuberculosis antibodies were detected in sera and children were evaluated for allergy. In conclusions of the dissertation it is declared, that 3 months after BCG vaccination and at 1 year of age children, vaccinated as 3 months - old had stronger tuberculin reactions and better BCG scarring, in comparison to neonatal vaccination. Clear consistent patterns in anti-tuberculosis antibody levels were not established. BCG vaccination at 3 months of age reduced the risk of food –related allergic rash for girls in preschool period.

Advisors/Committee Members: Šitkauskienė, Brigita (Doctoral dissertation committee member), Tamošiūnas, Vytas Antanas (Doctoral dissertation committee member), Danila, Edvardas (Doctoral dissertation committee member), Narkevičiūtė, Irena (Doctoral dissertation opponent), Labanauskas, Liutauras (Doctoral dissertation opponent), Valiulis, Arūnas (Doctoral dissertation advisor), Usonis, Vytautas (Doctoral dissertation committee chair), Jankauskienė, Augustina (Doctoral dissertation committee member).

Subjects/Keywords: BCG vakcina; Tuberkulino mėginys; Tuberkuliozė; Alergija; Vaikai; BCG vaccine; Tuberculin test; Tuberculosis; Allergy; Children

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sučilienė, E. (2010). Skirtingu laiku BCG vakcinomis skiepytų vaikų tuberkulino reakcijos ikimokykliniu laikotarpiu. (Doctoral Dissertation). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105347-37189 ;

Chicago Manual of Style (16^th Edition):

Sučilienė, Elena. “Skirtingu laiku BCG vakcinomis skiepytų vaikų tuberkulino reakcijos ikimokykliniu laikotarpiu.” 2010. Doctoral Dissertation, Vilnius University. Accessed February 27, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105347-37189 ;.

MLA Handbook (7^th Edition):

Sučilienė, Elena. “Skirtingu laiku BCG vakcinomis skiepytų vaikų tuberkulino reakcijos ikimokykliniu laikotarpiu.” 2010. Web. 27 Feb 2021.

Vancouver:

Sučilienė E. Skirtingu laiku BCG vakcinomis skiepytų vaikų tuberkulino reakcijos ikimokykliniu laikotarpiu. [Internet] [Doctoral dissertation]. Vilnius University; 2010. [cited 2021 Feb 27]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105347-37189 ;.

Council of Science Editors:

Sučilienė E. Skirtingu laiku BCG vakcinomis skiepytų vaikų tuberkulino reakcijos ikimokykliniu laikotarpiu. [Doctoral Dissertation]. Vilnius University; 2010. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105347-37189 ;

Vilnius University

12. Sučilienė, Elena. Tuberculin reactivity of children vaccinated at different age with BCG vaccines in preschool period.

Degree: PhD, Medicine, 2010, Vilnius University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105456-08947 ;

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Object of dissertation: The influence of different BCG vaccination schedules on the tuberculin reactivity, BCG scarring, specific serology and allergy. 509 children were included in… (more)

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Object of dissertation: The influence of different BCG vaccination schedules on the tuberculin reactivity, BCG scarring, specific serology and allergy. 509 children were included in this research, all of them received BCG vaccination with standard or half dosage as newborns or 3-months old. 3 months after BCG vaccination and at one, two, and six years of age they were tested with tuberculin, and examined for BCG scarring. Anti-tuberculosis antibodies were detected in sera and children were evaluated for allergy. In conclusions of the dissertation it is declared, that 3 months after BCG vaccination and at 1 year of age children, vaccinated as 3 months - old had stronger tuberculin reactions and better BCG scarring, in comparison to neonatal vaccination. Clear consistent patterns in anti-tuberculosis antibody levels were not established. BCG vaccination at 3 months of age reduced the risk of food –related allergic rash for girls in preschool period.

Disertacijos objektas: įvairių BCG skiepijimo režimų įtaka tuberkulino reakcijos išraiškai, vietinei BCG žymei, specifinei serologijai, alergijos klinikai vaikams iki 6 m. Tyrime dalyvavo 509 vaikai, vakcinuoti įprasta arba pusine BCG vakcinos doze naujagimio ar 3 mėn. amžiaus. Jiems 3 mėn. po BCG vakcinacijos, 1, 2 ir 6 m. atliktas tuberkulino mėginys, įvertintas BCG randelis, ištirti prieštuberkulioziniai antikūnai kraujo serume, įvertintos alerginės būklės. Disertacijos išvadose konstatuojama, kad pusine BCG vakcina skiepytųjų tuberkulino reakcijos silpnesnės, o susidariusi vietinė žymė mažesnė, o 3 mėn. BCG vakcinuotų vaikų tuberkulino reakcijos yra stipresnės, o susidariusi vietinė BCG žymė dažnesnė, nei skiepijant įprasta BCG vakcina naujagimio amžiaus vaikus lyginant su įprasta BCG vakcina naujagimio amžiaus skiepytais vaikais 3 mėn. po BCG vakcinacijos ar 1 m. vaikams. Aiškių prieštuberkuliozinių antikūnų dėsningumų nepavyko aptikti. 3 mėn. amžiaus BCG vakcinacija sumažino su maistu siejamų alerginių bėrimų riziką ikimokyklinio amžiaus mergaitėms.

Advisors/Committee Members: Usonis, Vytautas (Doctoral dissertation committee chair), Šitkauskienė, Brigita (Doctoral dissertation committee member), Jankauskienė, Augustina (Doctoral dissertation committee member), Tamošiūnas, Vytas Antanas (Doctoral dissertation committee member), Danila, Edvardas (Doctoral dissertation committee member), Narkevičiūtė, Irena (Doctoral dissertation opponent), Labanauskas, Liutauras (Doctoral dissertation opponent), Valiulis, Arūnas (Doctoral dissertation advisor).

Subjects/Keywords: BCG vaccine; Tuberculin test; Tuberculosis; Allergy; Children; BCG vakcina; Tuberkulino mėginys; Tuberkuliozė; Alergija; Vaikai

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sučilienė, E. (2010). Tuberculin reactivity of children vaccinated at different age with BCG vaccines in preschool period. (Doctoral Dissertation). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105456-08947 ;

Chicago Manual of Style (16^th Edition):

Sučilienė, Elena. “Tuberculin reactivity of children vaccinated at different age with BCG vaccines in preschool period.” 2010. Doctoral Dissertation, Vilnius University. Accessed February 27, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105456-08947 ;.

MLA Handbook (7^th Edition):

Sučilienė, Elena. “Tuberculin reactivity of children vaccinated at different age with BCG vaccines in preschool period.” 2010. Web. 27 Feb 2021.

Vancouver:

Sučilienė E. Tuberculin reactivity of children vaccinated at different age with BCG vaccines in preschool period. [Internet] [Doctoral dissertation]. Vilnius University; 2010. [cited 2021 Feb 27]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105456-08947 ;.

Council of Science Editors:

Sučilienė E. Tuberculin reactivity of children vaccinated at different age with BCG vaccines in preschool period. [Doctoral Dissertation]. Vilnius University; 2010. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105456-08947 ;

Iowa State University

13. Pemberton, John Robert. Chemical, physical, and immunological characteristics of purified protein derivatives from Mycobacterium bovis.

Degree: 1971, Iowa State University

URL: https://lib.dr.iastate.edu/rtd/4573

Subjects/Keywords: Immunochemistry; Tuberculin test; Mycobacterium bovis; Biochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pemberton, J. R. (1971). Chemical, physical, and immunological characteristics of purified protein derivatives from Mycobacterium bovis. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/rtd/4573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pemberton, John Robert. “Chemical, physical, and immunological characteristics of purified protein derivatives from Mycobacterium bovis.” 1971. Thesis, Iowa State University. Accessed February 27, 2021. https://lib.dr.iastate.edu/rtd/4573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pemberton, John Robert. “Chemical, physical, and immunological characteristics of purified protein derivatives from Mycobacterium bovis.” 1971. Web. 27 Feb 2021.

Vancouver:

Pemberton JR. Chemical, physical, and immunological characteristics of purified protein derivatives from Mycobacterium bovis. [Internet] [Thesis]. Iowa State University; 1971. [cited 2021 Feb 27]. Available from: https://lib.dr.iastate.edu/rtd/4573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pemberton JR. Chemical, physical, and immunological characteristics of purified protein derivatives from Mycobacterium bovis. [Thesis]. Iowa State University; 1971. Available from: https://lib.dr.iastate.edu/rtd/4573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Iowa State University

14. Kopecky, Kenneth Edward. Evaluation of the intravenous tuberculin test in cattle.

Degree: 1966, Iowa State University

URL: https://lib.dr.iastate.edu/rtd/18165

http://www.worldcat.org/oclc/11001888

Subjects/Keywords: Tuberculin; Tuberculosis in cattle; Veterinary Microbiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kopecky, K. E. (1966). Evaluation of the intravenous tuberculin test in cattle. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/rtd/18165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kopecky, Kenneth Edward. “Evaluation of the intravenous tuberculin test in cattle.” 1966. Thesis, Iowa State University. Accessed February 27, 2021. https://lib.dr.iastate.edu/rtd/18165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kopecky, Kenneth Edward. “Evaluation of the intravenous tuberculin test in cattle.” 1966. Web. 27 Feb 2021.

Vancouver:

Kopecky KE. Evaluation of the intravenous tuberculin test in cattle. [Internet] [Thesis]. Iowa State University; 1966. [cited 2021 Feb 27]. Available from: https://lib.dr.iastate.edu/rtd/18165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kopecky KE. Evaluation of the intravenous tuberculin test in cattle. [Thesis]. Iowa State University; 1966. Available from: https://lib.dr.iastate.edu/rtd/18165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Carolina

15. Giovannetti, Mary C. Tuberculosis Screening in New Healthcare Employees: A Comparison of QuantiFERON®-TB Gold In-Tube Test and Tuberculin Skin Test.

Degree: Doctor of Nursing Practice, College of Nursing, 2017, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/4195

► Background: Streamlining onboarding processes for new hires to maximize efficiency and reduce costs while meeting regulatory requirements is a constant challenge for healthcare systems’… (more)

▼ Background: Streamlining onboarding processes for new hires to maximize efficiency and reduce costs while meeting regulatory requirements is a constant challenge for healthcare systems’ Employee Health staff. Health screening is a required step and includes obtaining a detailed health history, tuberculosis screening, drug screens, immunizations, fit for duty examinations, obtaining medical records, clarification of disability accommodations, pre-work screens, and other tests which are time consuming and result in delays in hire dates. Faced with a high volume of potential new employee hires a major southeast healthcare system was concerned about delays in new hire start dates. The two-step tuberculin skin test administration and follow-up process was identified as a potential area for concern to improve onboarding efficiency. Method: A quality improvement study was designed and implemented to compare baseline testing for new employees with an Interferon-Gamma Release Assay (IGRA) known as QuantiFERON®-TB Gold In-Tube Test (QFT®-GIT) to the two step PPD Tuberculin Skin Test (TST) for tuberculosis screening time, overall onboarding time, compliance with screening within 10 days of hire date, and associated costs. A retrospective electronic record review included a sample of 484 new hire employees. Results: Results showed that the QFT®-GIT for tuberculosis screening in comparison to the TST testing significantly reduced tuberculosis screening time for new hire employees (TST = 8.03 days, QFT®-GIT = 4.11 days; p<.0001) and overall onboarding time (TST = 7.92 days, QFT®-GIT = 5.07 days; p<.0001) while improving compliance with tuberculosis screening within 10 days of hire date (TST = 92.92%, QFT®-GIT =100%; p<.0001). Conclusions: The utilization of QFT®-GIT for tuberculosis screening of new employees significantly reduced screening and onboarding time while improving compliance with screening within 10 days of the hire date. Anecdotal feedback from hiring managers and senior management indicated improved satisfaction with the Employee Health hiring process. Implications: Healthcare systems should consider implementation of an IGRA to streamline processes for onboarding new employees. New processes require negotiations between healthcare systems and lab vendors, changes in policies and procedures, and employee health and laboratory staff development. Future research should focus on cost analyses, as well as, IGRA use for annual screenings. Advisors/Committee Members: Stephanie Burgess.

Subjects/Keywords: Medicine and Health Sciences; Nursing; Tuberculosis Screening; Tuberculin Skin Test; Gold In-Tube Test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Giovannetti, M. C. (2017). Tuberculosis Screening in New Healthcare Employees: A Comparison of QuantiFERON®-TB Gold In-Tube Test and Tuberculin Skin Test. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/4195

Chicago Manual of Style (16^th Edition):

Giovannetti, Mary C. “Tuberculosis Screening in New Healthcare Employees: A Comparison of QuantiFERON®-TB Gold In-Tube Test and Tuberculin Skin Test.” 2017. Doctoral Dissertation, University of South Carolina. Accessed February 27, 2021. https://scholarcommons.sc.edu/etd/4195.

MLA Handbook (7^th Edition):

Giovannetti, Mary C. “Tuberculosis Screening in New Healthcare Employees: A Comparison of QuantiFERON®-TB Gold In-Tube Test and Tuberculin Skin Test.” 2017. Web. 27 Feb 2021.

Vancouver:

Giovannetti MC. Tuberculosis Screening in New Healthcare Employees: A Comparison of QuantiFERON®-TB Gold In-Tube Test and Tuberculin Skin Test. [Internet] [Doctoral dissertation]. University of South Carolina; 2017. [cited 2021 Feb 27]. Available from: https://scholarcommons.sc.edu/etd/4195.

Council of Science Editors:

Giovannetti MC. Tuberculosis Screening in New Healthcare Employees: A Comparison of QuantiFERON®-TB Gold In-Tube Test and Tuberculin Skin Test. [Doctoral Dissertation]. University of South Carolina; 2017. Available from: https://scholarcommons.sc.edu/etd/4195

16. Κάπελλα, Μαρία. Επιδημιολογική διερεύνηση του δείκτη διαμόλυνσης από μυκοβακτηρίδιο της φυματίωσης των επαγγελματιών υγείας.

Degree: 2011, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/27927

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Aim of this study was to estimate the incidence of Tuberculin Skin Test (TST) conversion in health care professionals and to assess the risk factors… (more)

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Aim of this study was to estimate the incidence of Tuberculin Skin Test (TST) conversion in health care professionals and to assess the risk factors for the transmission of mycobacterium tuberculosis to health care professionals. Material and Methods: The sample consisted of 115 persons from the nursing and support staff of three large hospitals in Athens. Tuberculin Skin Test (TST) was done using the intradermal injection of tuberculin (Mantoux technique). Along with the implementation of the Tuberculin Skin Test (Mantoux) a questionnaire was completed by the participants that provided the possible source of contamination in case of a positive Mantoux or illness from tuberculosis. Results: Of the 115 participants, 4.3% resulted positive to the Mantoux and did not further participate in the study. At the end of the first year 22% of the participants who were negative in the initial Mantoux became positive. People who worked in Respiratory Medicine Department showed a significantly higher percentage (30.5%) of positive Mantoux compared to those working in lnternal Medicine Department (12%). Greater impact on the occurrence of a positive Mantoux at 1 year was found among those aged over 42 years compared with those below 32 years. (p=0,046%) Conclusions: 1) The department, in which a health care professional works, plays an important role in the conversion of Mantoux. 2) It appears that age is the major risk factor for the infection with mycobacterium tuberculosis.

Σκοπός της παρούσης μελέτης ήταν ο υπολογισμός του δείκτη διαμόλυνσης από φυματίωση (θετική Mantoux) και η εκτίμηση των παραγόντων κινδύνου της μετάδοσης του Μυκοβακτηριδίου της Φυματίωσης στους επαγγελματίες υγείας. Υλικό και Μέθοδος: Το δείγμα της μελέτης αποτέλεσαν 115 άτομα από το νοσηλευτικό και βοηθητικό προσωπικό τριών μεγάλων Νοσοκομείων της Αττικής. Ο έλεγχος της δερμοαντίδρασης στη φυματίνη έγινε με την ενδοδερμική ένεση φυματίνης κατά Mantoux (Tuberculin Skin Test-TST). Παράλληλα με την πραγματοποίηση της δερμοαντίδρασης φυματίνης (Mantoux) συμπληρώθηκε από τους συμμετέχοντες ειδικά σχεδιασμένο ερωτηματολόγιο, που θα προσανατολίζει την πιθανή πηγή μόλυνσης σε περίπτωση θετικής Mantoux ή νόσησης από φυματίωση. Αποτελέσματα: Από τους 115 συμμετέχοντες, το 4,3% βρέθηκε θετικό στη δερμοαντίδραση Mantoux κατά την 1η εξέταση και δε συμμετείχε περαιτέρω στη μελέτη. Μέσα στο έτος θετικοποιήθηκε το 22% των συμμετεχόντων που ήταν αρνητικοί στην αρχική Mantoux. Τα άτομα που εργάζονταν σε πνευμονολογική κλινική παρουσίαζαν σημαντικά υψηλότερο ποσοστό (30,5%) θετικών Mantoux σε σύγκριση με τα άτομα που εργάζονταν σε παθολογική κλινική (12%). Μεγαλύτερη επίπτωση για την εμφάνιση θετικής Mantoux στο 1 έτος βρέθηκε στα άτομα ηλικίας άνω των 42 ετών σε σύγκριση με τα άτομα κάτω των 32 ετών. (p=0,046%) Συμπεράσματα: 1) Το τμήμα, στο οποίο εργάζεται το προσωπικό υγείας παίζει σημαντικό ρόλο στη θετικοποίηση της Mantoux. 2) Φαίνεται ότι η ηλικία είναι ο βασικός παράγοντας κινδύνου λοίμωξης από το Μυκοβακτηρίδιο της Φυματίωσης.

Subjects/Keywords: Δερμοαντίδραση φυματίνης; Επαγγελματίες υγείας; Μυκοβακτηρίδιο φυματίωσης; Tuberculin skin test; Health care professionals; Mycobacterium tuberculosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Κάπελλα, . �. (2011). Επιδημιολογική διερεύνηση του δείκτη διαμόλυνσης από μυκοβακτηρίδιο της φυματίωσης των επαγγελματιών υγείας. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/27927

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Κάπελλα, Μαρία. “Επιδημιολογική διερεύνηση του δείκτη διαμόλυνσης από μυκοβακτηρίδιο της φυματίωσης των επαγγελματιών υγείας.” 2011. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed February 27, 2021. http://hdl.handle.net/10442/hedi/27927.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Κάπελλα, Μαρία. “Επιδημιολογική διερεύνηση του δείκτη διαμόλυνσης από μυκοβακτηρίδιο της φυματίωσης των επαγγελματιών υγείας.” 2011. Web. 27 Feb 2021.

Vancouver:

Κάπελλα �. Επιδημιολογική διερεύνηση του δείκτη διαμόλυνσης από μυκοβακτηρίδιο της φυματίωσης των επαγγελματιών υγείας. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2011. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/27927.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Κάπελλα �. Επιδημιολογική διερεύνηση του δείκτη διαμόλυνσης από μυκοβακτηρίδιο της φυματίωσης των επαγγελματιών υγείας. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2011. Available from: http://hdl.handle.net/10442/hedi/27927

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Hatzara, Chrysoula. Μελέτη της λοίμωξης από το μυκοβακτηρίδιο της φυματίωσης σε ασθενείς με αυτοάνοσες ρευματικές παθήσεις.

Degree: 2019, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/46771

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Objectives: The determination of the rate of tuberculosis (TB) screening test conversion during anti-tumour necrosis factor (TNF) therapy in rheumatic patients with negative baseline screening.Methods:… (more)

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Objectives: The determination of the rate of tuberculosis (TB) screening test conversion during anti-tumour necrosis factor (TNF) therapy in rheumatic patients with negative baseline screening.Methods: Prospective study of rheumatic patients with negative baseline TB screening (tuberculin skin test (TST): <5 mm, and negative T-SPOT.TB, QuantiFERON-TB Gold In Tube (QFT-GIT) and chest X-ray) treated with anti-TNF agents. All patients underwent re-screening for TB with all assays 1 year later. Factors associated with TB test conversion were analysed and compared between 'converters' and 'non-converters'. Results: Seventy patients (mean age 50.6±15.5 years) with rheumatic disease (33 with rheumatoid arthritis, 33 with spondyloarthropathies and 4 with other conditions) were enrolled. Patients were treated with different anti-TNFs (27 with adalimumab, 14 etanercept, 16 infliximab, 8 golimumab, 5 certolizumab pegol) for 1 year. Twenty patients (29%) displayed conversion of at least one screening assay 12 months after anti-TNF therapy: conversion of TST occurred in 9 (13%), T-SPOT.TB in 7 (10%) and QFT-GIT in 5 (7%). Only one patient had concomitant conversion of more than one screening test. Univariate and multivariate analysis revealed that only infliximab was associated with a decreased rate of TB screening assay conversion (OR 0.048, 95% CI 0.004 to 0.606, p=0.017). No patient (40% received isoniazid therapy) developed active TB during follow-up (27±12 months). Conclusions: Approximately one third of patients with negative baseline TB screening develop conversion of at least one screening test during anti-TNF treatment. These findings should be considered when designing rescreening strategies and contemplating latent TB therapy.

Σκοπός της παρούσας μελέτης ήταν να μελετηθεί η συχνότητα θετικοποίησης των δοκιμασιών για φυματίωση (ΤΒ) (TST, IGRAs) κατά τη διάρκεια αγωγής με anti-TNF παράγοντες σε ασθενείς με αρνητικό έλεγχο προ της έναρξης αγωγής. Μέθοδοι. Πρόκειται για μια προοπτική μελέτη ασθενών με ρευματικές παθήσεις με αρνητικό αρχικό έλεγχο (δερματική φυματινοαντίδραση (TST <5 mm) και αρνητικές μέθοδοι T-SPOT.TB, Quantiferon-TB Gold In Tube(QFT-GIT) και ακτινογραφία θώρακα) και οι οποιοι υποβλήθηκαν σε αγωγή με anti-TNF παράγοντες. Όλοι οι ασθενείς υποβλήθηκαν σε επαναληπτικό έλεγχο για ΤΒ ένα έτος μετά. Παράγοντες που σχετίζονται με τη μετατροπή των δοκιμασιών της ΤΒ αναλύθηκαν και συγκρίθηκαν μεταξύ εκείνων που «θετικοποίησαν» και εκείνων που «δεν θετικοποίησαν». Αποτελέσματα: 70 ασθενείς (μέση τιμή ηλικίας 50±15,5 έτη) με ρευματολογικές παθήσεις (33 με ρευματοειδή αρθρίτιδα, 33 με σπονδυλοαρθροπάθειες και 4 με άλλες νόσους) συμπεριλήφθηκαν στη μελέτη. Οι ασθενείς έλαβαν αγωγή με διάφορους anti-TNF παράγοντες (27 έλαβαν adalimumab, 14 etanercept, 16 infliximab, 8 golimumab, 5 certolizumab pegol) για ένα έτος. 12 μήνες μετά παρατηρήθηκε σε είκοσι ασθενείς (29%) τροποποίηση (θετικοποίηση) σε μία τουλάχιστον μέθοδο ελέγχου : θετικοποίηση στην TST παρατηρήθηκε σε 9 (13%), T-SPOT.TB σε 7 (10%) και QFT-GIT σε 5 (7%)…

Subjects/Keywords: Φυματίωση; Δερματική φυματινοαντίδραση; Anti-TNF; Tuberculosis; Tuberculin skin test; T-SPOT.TB; QuantiFERON-TB

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hatzara, C. (2019). Μελέτη της λοίμωξης από το μυκοβακτηρίδιο της φυματίωσης σε ασθενείς με αυτοάνοσες ρευματικές παθήσεις. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/46771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hatzara, Chrysoula. “Μελέτη της λοίμωξης από το μυκοβακτηρίδιο της φυματίωσης σε ασθενείς με αυτοάνοσες ρευματικές παθήσεις.” 2019. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed February 27, 2021. http://hdl.handle.net/10442/hedi/46771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hatzara, Chrysoula. “Μελέτη της λοίμωξης από το μυκοβακτηρίδιο της φυματίωσης σε ασθενείς με αυτοάνοσες ρευματικές παθήσεις.” 2019. Web. 27 Feb 2021.

Vancouver:

Hatzara C. Μελέτη της λοίμωξης από το μυκοβακτηρίδιο της φυματίωσης σε ασθενείς με αυτοάνοσες ρευματικές παθήσεις. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/46771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hatzara C. Μελέτη της λοίμωξης από το μυκοβακτηρίδιο της φυματίωσης σε ασθενείς με αυτοάνοσες ρευματικές παθήσεις. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. Available from: http://hdl.handle.net/10442/hedi/46771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

18. Rogerson, Thomas Edward. Evidence based testing and outcomes in transplantation .

Degree: 2014, University of Sydney

URL: http://hdl.handle.net/2123/12859

► The use of diagnostic tests is central to the practice of modern medicine, but knowing which test to use, and when, can be problematic. To… (more)

Subjects/Keywords: Solid organ transplantation; Tuberculosis; Tuberculin skin test; Interferon gamma release assay; Diagnosis; Evidence based medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rogerson, T. E. (2014). Evidence based testing and outcomes in transplantation . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/12859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rogerson, Thomas Edward. “Evidence based testing and outcomes in transplantation .” 2014. Thesis, University of Sydney. Accessed February 27, 2021. http://hdl.handle.net/2123/12859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rogerson, Thomas Edward. “Evidence based testing and outcomes in transplantation .” 2014. Web. 27 Feb 2021.

Vancouver:

Rogerson TE. Evidence based testing and outcomes in transplantation . [Internet] [Thesis]. University of Sydney; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2123/12859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rogerson TE. Evidence based testing and outcomes in transplantation . [Thesis]. University of Sydney; 2014. Available from: http://hdl.handle.net/2123/12859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Cheila Oliveira Lima Maia. Tuberculose infecÃÃo entre estudantes de graduaÃÃo da Ãrea da saÃde:estudo de prevalÃncia e avaliaÃÃo do conhecimento .

Degree: Master, 2013, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9542 ;

►

A infecÃÃo por Mycobacterium tuberculosis atinge um terÃo da populaÃÃo da terra, sendo considerada uma emergÃncia mundial. Pesquisas apontam para maior risco entre profissionais e… (more)

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A infecÃÃo por Mycobacterium tuberculosis atinge um terÃo da populaÃÃo da terra, sendo considerada uma emergÃncia mundial. Pesquisas apontam para maior risco entre profissionais e estudantes da Ãrea da saÃde. O estudo buscou identificar a prevalÃncia da infecÃÃo tuberculosa e o conhecimento dos alunos da Ãrea da saÃde sobre o tema. Foi realizada pesquisa do tipo transversal, de natureza quantitativa, com alunos de Medicina e Enfermagem da Universidade Federal do CearÃ, estratificados por ciclo do curso. Os participantes responderam a um questionÃrio sociodemogrÃfico e de conhecimentos sobre tuberculose e foi aplicada prova tuberculÃnica (PT). Foram considerados dois pontos de corte diferentes para PT positiva, ou seja, ≥ 5 mm (utilizado para populaÃÃo geral) e ≥ 10 mm (para profissionais de saÃde). Foram realizados os testes χÂ, χÂ de tendÃncia e razÃo de verossimilhanÃa para as associaÃÃes entre o resultado da PT, o conhecimento dos alunos e as variÃveis categÃricas. Compararam-se as mÃdias com os testes t de Student e Kruskal-Wallis. Foi considerado estatisticamente significante se p < 0,05. Dos 311 participantes do estudo, 69,5% eram do sexo feminino, 67,5% estavam na faixa etÃria de 20 a 24 anos e 90,7% apresentavam cicatriz de BCG. As caracterÃsticas socioeconÃmicas foram diferentes entre os dois cursos. Apenas 17,4% dos alunos relataram ter participado de treinamento sobre tuberculose. Cursavam o ciclo bÃsico 30,5% dos alunos, o ciclo clÃnico 38,3% e o internato ou estÃgio curricular supervisionado 31,2%. Dos estudantes de Medicina, 38 (21,6%) e 30 (17,0%) apresentaram PT de 5 a 9 mm e ≥ 10 mm, respectivamente. Na Enfermagem, a positividade foi de 5 a 9 mm em 21 (22,8%) e ≥ 10 mm em 26 (28,3%) dos alunos. A anÃlise do resultado da PT por ciclo do curso para a Medicina demonstrou mÃdia e desvio-padrÃo de 3,5 (Â 4,2) mm no ciclo bÃsico e de 5,3 (Â 4,5) mm no internato (p=0,013). No curso de Enfermagem, a mÃdia e o desvio-padrÃo da PT foram de 5,1 (Â 4,8) mm no inÃcio do curso e 5,2 (Â 5,4) mm ao fim do curso (p=0,464). O conhecimento dos alunos sobre os temas bÃsicos da tuberculose foi em geral de 56,05%, tendo crescido de 34,13% no ciclo bÃsico para 69,75% no internato/estÃgio curricular supervisionado. O estudo reforÃa a importÃncia da realizaÃÃo de inquÃritos tuberculÃnicos periÃdicos entre estudantes da Ãrea da saÃde, reforÃando a necessidade de implementaÃÃo de medidas de biosseguranÃa e educaÃÃo permanente sobre o tema para futuros profissionais de saÃde.

Infection with Mycobacterium tuberculosis (TB) affects one third of the worldâs population and is considered a global emergency. Research has shown an increased risk of TB among healthcare workers and students. The purpose of the study was to determine the prevalence of TB infection and evaluate the studentsâ knowledge of TB. A quantitative, cross-sectional study was conducted with 311 medical and nursing students from the Federal University of CearÃ stratified by period. Sociodemographic information was collected, a…

Advisors/Committee Members: MÃnica Cardoso FaÃanha, Paulo CÃsar de Almeida, ValÃria GÃes Ferreira Pinheiro, Roberto da Justa Pires Neto.

Subjects/Keywords: SAUDE PUBLICA; Tuberculose; Teste TuberculÃnico; Estudantes de Medicina; Estudantes de Enfermagem; tuberculosis; tuberculin test; medical students; nursing students

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maia, C. O. L. (2013). Tuberculose infecÃÃo entre estudantes de graduaÃÃo da Ãrea da saÃde:estudo de prevalÃncia e avaliaÃÃo do conhecimento . (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9542 ;

Chicago Manual of Style (16^th Edition):

Maia, Cheila Oliveira Lima. “Tuberculose infecÃÃo entre estudantes de graduaÃÃo da Ãrea da saÃde:estudo de prevalÃncia e avaliaÃÃo do conhecimento .” 2013. Masters Thesis, Universidade Federal do Ceará. Accessed February 27, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9542 ;.

MLA Handbook (7^th Edition):

Maia, Cheila Oliveira Lima. “Tuberculose infecÃÃo entre estudantes de graduaÃÃo da Ãrea da saÃde:estudo de prevalÃncia e avaliaÃÃo do conhecimento .” 2013. Web. 27 Feb 2021.

Vancouver:

Maia COL. Tuberculose infecÃÃo entre estudantes de graduaÃÃo da Ãrea da saÃde:estudo de prevalÃncia e avaliaÃÃo do conhecimento . [Internet] [Masters thesis]. Universidade Federal do Ceará 2013. [cited 2021 Feb 27]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9542 ;.

Council of Science Editors:

Maia COL. Tuberculose infecÃÃo entre estudantes de graduaÃÃo da Ãrea da saÃde:estudo de prevalÃncia e avaliaÃÃo do conhecimento . [Masters Thesis]. Universidade Federal do Ceará 2013. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9542 ;

20. Cyrillo, Fernanda Cavallini. Padronização do alergoteste da tuberculina em ovinos (Ovis aries).

Degree: Mestrado, Clínica Veterinária, 2006, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-15062007-165924/ ;

►

A inexistência de padrões nacionais para a realização e interpretação da prova de tuberculina em ovinos motivou o presente trabalho, pois apesar da tuberculose não… (more)

▼

A inexistência de padrões nacionais para a realização e interpretação da prova de tuberculina em ovinos motivou o presente trabalho, pois apesar da tuberculose não estar incluída em Plano Nacional de Controle e Erradicação em pequenos ruminantes, estabelece a legislação vigente que é obrigatório o sacrifício de animais com essa zoonose, sendo o diagnóstico firmado nesses animais principalmente através do alergoteste tuberculínico. Assim, esta pesquisa visou além de avaliar reações clínicas provocadas pela resposta imuno-alérgica intradérmica à tuberculina, estabelecer valores de referência para a interpretação da reação em ovinos experimentalmente inoculados com antígenos de cepas padrões de Mycobacterium bovis e Mycobacterium avium. Utilizou-se 30 ovinos, clinicamente sadios, negativos à prova de tuberculina cervical comparativa (TCC), segundo critérios estabelecidos pelo Ministério da Agricultura, Pecuária e Abastecimento (MAPA) através do Plano Nacional de Controle e Erradicação da Brucelose e Tuberculose (PNCEBT) em bovinos e bubalinos, distribuídos por três grupos de 10 animais cada, a saber: A - sensibilizados com M. avium; B - sensibilizados com M. bovis e C (Controle) - que receberam injeção de solução fisiológica. Os ovinos foram monitorados através de exames físicos e complementares semanais. Após 45 dias da sensibilização, realizou-se a prova de TCC com reação medida pela variação da espessura da pele com cutímetro de mola, nos seguintes momentos: antes da aplicação das tuberculinas (PPDs); 12h, 24h, 48h, 72h e 96h após a aplicação das mesmas. Em relação à reação ao PPD bovino, no teste cervical simples, lido às 72 horas (± 6 horas) pós-tuberculinização (p. t.), considerou-se uma reação como positiva, quando o aumento da espessura da pele foi igual ou maior que 2,49 mm; como inconclusiva, com as medidas de aumento entre 1,00 e 2,48 mm, e como reação negativa, aumentos da espessura da pele inferiores a 1,00 mm, sendo estes valores propostos como padrão para o teste intradérmico simples na região cervical. A análise dos resultados da leitura do teste cervical comparativo, realizada às 72 horas (± 6 horas) p. t., permitiu concluir-se que o animal poderá ser considerado com resposta: positiva, quando a reação ao PPD bovino superar aquela ao aviário em pelo menos 2,00 mm; inconclusiva, quando a reação ao PPD bovino for maior que aquela ao aviário, com diferença entre 1,00 e 1,99 mm, e negativa quando a reação bovina for menor que a aviária ou > em até 0,99 mm. Na avaliação histológica das respostas tuberculínicas homólogas, 96 horas após a injeção do PPD, constatou-se a presença de moderado a intenso infiltrado inflamatória, constituído, preferencialmente, por células mononucleares.

The inexistence of national patterns for the realization and interpretation of tuberculin test in sheep motivated this research. Although tuberculosis is not included in the National Plan for the Control and Eradication in small ruminants, the current legislation has made it mandatory the sacrifice of animals with…

Advisors/Committee Members: Benesi, Fernando José.

Subjects/Keywords: Ovinos; Sheep; Tuberculin (PPD); Tuberculina PPD; Tuberculose; Tuberculosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cyrillo, F. C. (2006). Padronização do alergoteste da tuberculina em ovinos (Ovis aries). (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10136/tde-15062007-165924/ ;

Chicago Manual of Style (16^th Edition):

Cyrillo, Fernanda Cavallini. “Padronização do alergoteste da tuberculina em ovinos (Ovis aries).” 2006. Masters Thesis, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-15062007-165924/ ;.

MLA Handbook (7^th Edition):

Cyrillo, Fernanda Cavallini. “Padronização do alergoteste da tuberculina em ovinos (Ovis aries).” 2006. Web. 27 Feb 2021.

Vancouver:

Cyrillo FC. Padronização do alergoteste da tuberculina em ovinos (Ovis aries). [Internet] [Masters thesis]. University of São Paulo; 2006. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-15062007-165924/ ;.

Council of Science Editors:

Cyrillo FC. Padronização do alergoteste da tuberculina em ovinos (Ovis aries). [Masters Thesis]. University of São Paulo; 2006. Available from: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-15062007-165924/ ;

21. Oliveira, Flávia Carolina Souza de. Padronização do teste imunoalérgico e de reação imunoenzimática aplicados ao diagnóstico da tuberculose e micobacterioses em suínos (Sus scrofa) experimentalmente sensibilizados com suspensões oleosas de M. bovis ou M. avium inativados.

Degree: PhD, Epidemiologia Experimental Aplicada às Zoonoses, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-15102012-091548/ ;

►

Foi investigado o valor diagnóstico da resposta alérgica cutânea à tuberculina e do ELISA indireto, com antígeno recombinante MPB 70, em leitões experimentalmente sensibilizados, pela… (more)

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Foi investigado o valor diagnóstico da resposta alérgica cutânea à tuberculina e do ELISA indireto, com antígeno recombinante MPB 70, em leitões experimentalmente sensibilizados, pela via intramuscular, com suspensões oleosas de M. bovis ou M. avium inativados. Foram utilizados 91 animais divididos em quatro grupos. Os grupos A e B, cada um com 25 indivíduos, grupos C e D com 21 e 20 indivíduos respectivamente, balanceando-se as características de raça, linhagem, faixa etária e sexo. Aos 21 dias de idade, todos os animais foram submetidos a uma triagem com a aplicação de tuberculina PPD de M. bovis, pela via intradérmica na base da orelha e não houve qualquer tipo de reação. Decorridos 60 dias do teste tuberculínico de triagem, o grupo A, recebeu injeção intramuscular de 0,5 mL de uma suspensão oleosa de M. avium estirpe D4; o grupo B, recebeu 0,5 mL de uma suspensão oleosa de M. bovis estirpe AN5; o grupo C (controle I), recebeu 0,5 mL do adjuvante oleoso e o grupo D (controle II), recebeu 0,5 mL de solução fisiológica. Foi realizado o exame histopatológico de biopsias das reações cutâneas e a colheita de sangue para o teste de ELISA de captura. Após 30 dias da sensibilização, foi efetuada a prova de tuberculinização comparativa com reação medida pela variação da espessura da pele com paquímetro às 0h, 24h, 48h e 72h, após a aplicação das tuberculinas. No teste comparativo, lido às 72 horas, a reação foi considerada negativa quando a diferença das reações entre o PPD bovino e o PPD aviário foi menor que 6,7 mm; suspeito ou inconclusivo quando a diferença se situou na faixa de 6,7 a 7,5 mm; e positiva para o tipo de PPD, considerando-se tuberculose para PPD M. bovis e micobacteriose para PPD M. avium, quando a diferença da reação foi superior a 7,5 mm. Nos exames histopatológicos, foi observado intenso infiltrado inflamatório linfocitário no local das reações intradérmicas dos animais testados com o PPD homologo ao tipo de micobactéria utilizada na suspensão oleosa sensibilizante. O ensaio de ELISA com antígeno, MPB 70 recombinante, foi capaz de revelar a presença de anticorpos contra o M. bovis, porém não revelou anticorpos para M. avium.

The diagnostic value of the cutaneous allergic response to tuberculin and Indirect ELISA test was investigated using MPB 70 recombinant antigen, in piglets experimentally sensitized intramuscularly with the oily suspensions of inactivated M. bovis or M. avium. The ninety-one animals used were divided into four groups. The groups A and B were formed each with 25 individuals, and groups C and D, with 21 and 20 individuals, respectively, balancing the characteristics of race, ancestry, age and sex. At the age of 21 days, all the animals were submitted to the screening test with the use of M. bovis PPD, by the intradermal route at the base of the ear and no reaction was detected. Sixty days after the screening tuberculin test, animals of the group A were injected intramuscularly with 0.5 mL of oily suspension of M. avium D4 strain; animals of group B received 0.5 mL of an…

Advisors/Committee Members: Vasconcellos, Silvio Arruda.

Subjects/Keywords: ELISA test; Micobacteriose; Mycobacteriosis; Padronização; Pigs; Standardization; Suínos; Teste de Elisa; Teste de tuberculinização; Tuberculin test; Tuberculose; Tuberculosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oliveira, F. C. S. d. (2012). Padronização do teste imunoalérgico e de reação imunoenzimática aplicados ao diagnóstico da tuberculose e micobacterioses em suínos (Sus scrofa) experimentalmente sensibilizados com suspensões oleosas de M. bovis ou M. avium inativados. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10134/tde-15102012-091548/ ;

Chicago Manual of Style (16^th Edition):

Oliveira, Flávia Carolina Souza de. “Padronização do teste imunoalérgico e de reação imunoenzimática aplicados ao diagnóstico da tuberculose e micobacterioses em suínos (Sus scrofa) experimentalmente sensibilizados com suspensões oleosas de M. bovis ou M. avium inativados.” 2012. Doctoral Dissertation, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-15102012-091548/ ;.

MLA Handbook (7^th Edition):

Oliveira, Flávia Carolina Souza de. “Padronização do teste imunoalérgico e de reação imunoenzimática aplicados ao diagnóstico da tuberculose e micobacterioses em suínos (Sus scrofa) experimentalmente sensibilizados com suspensões oleosas de M. bovis ou M. avium inativados.” 2012. Web. 27 Feb 2021.

Vancouver:

Oliveira FCSd. Padronização do teste imunoalérgico e de reação imunoenzimática aplicados ao diagnóstico da tuberculose e micobacterioses em suínos (Sus scrofa) experimentalmente sensibilizados com suspensões oleosas de M. bovis ou M. avium inativados. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-15102012-091548/ ;.

Council of Science Editors:

Oliveira FCSd. Padronização do teste imunoalérgico e de reação imunoenzimática aplicados ao diagnóstico da tuberculose e micobacterioses em suínos (Sus scrofa) experimentalmente sensibilizados com suspensões oleosas de M. bovis ou M. avium inativados. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/10/10134/tde-15102012-091548/ ;

22. França, Flavia Aparecida de Moraes. Teste tuberculínico: comparação de dois instrumentos de leitura.

Degree: PhD, Epidemiologia, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/6/6132/tde-17052012-104258/ ;

►

Introdução- A busca ativa de indivíduos infectados pelo Mycobacterium tuberculosis, com o auxílio do teste tuberculínico, principalmente em populações de detentos, moradores de rua, infectados… (more)

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Introdução- A busca ativa de indivíduos infectados pelo Mycobacterium tuberculosis, com o auxílio do teste tuberculínico, principalmente em populações de detentos, moradores de rua, infectados pelo vírus do HIV entre outras, tem como objetivo prevenir a evolução da infecção para a doença tuberculose e auxiliar o conhecimento de novos casos da doença. O teste tuberculínico é uma importante ferramenta, para identificar os indivíduos reatores (infectados) e não reatores (não infectados). Ele pode ser aplicado a partir de várias técnicas, mas a que permite a padronização e a comparação dos resultados é a técnica intradérmica de Mantoux, a mais usada atualmente. No Brasil, a leitura do resultado do teste tuberculínico é realizada, por recomendação do Ministério de Saúde, com régua milimetrada. Para seu uso é necessário um treinamento rigoroso, o que tem contribuído para a diminuição de leitores do teste tuberculínico na rotina dos serviços de saúde. Como alternativa temos outro instrumento, paquímetro, ainda não padronizado no Brasil. Outros países o utilizam nas rotinas dos serviços de saúde para busca de indivíduos reatores ou não ao teste tuberculínico, ele não cabe para aferição ou inquéritos epidemiológicos. Objetivo- Comparar os instrumentos de leitura dos resultados do teste tuberculínico obtidos através da leitura padronizada, feita por régua milimetrada, e a leitura, não padronizada, feita por paquímetro. Métodos- Estudo descritivo realizado numa população prisional de uma Penitenciária e de um Centro de Detenção Provisória, da cidade de Guarulhos, Grande São Paulo, entre os meses de março a junho de 2008. Foi realizada a leitura do teste tuberculínico de forma dupla cega, por dois leitores, com instrumentos diferentes, paquímetro e régua milimetrada. Resultados- Foram administrados testes tuberculínicos em 1954 indivíduos; destes 111 foram excluídos por não terem comparecido à leitura do teste, resultando em uma amostra de 1843 indivíduos divididos em 1059 (57,5 por cento ) na Penitenciária e 784 (42,5 por cento ) no Centro de Detenção Provisória. Os resultados comparativos entre os dois instrumentos, quando avaliados os reatores com os não reatores, foram altos e equivalentes, pois a sensibilidade (93 por cento ) e a especificidade (97 por cento ) foram praticamente as mesmas. A média da concordância foi alta entre os dois instrumentos (95,5 por cento ) e a discordância foi baixa (4,5 por cento ). O Ministério da Saúde preconiza uma concordância acima de 80 por cento para aferição de novos leitores. Conclusões- Com este estudo observamos que o paquímetro pode ser considerado equivalente à régua milimetrada e poderá ser uma alternativa à régua para a leitura do teste tuberculínico no Brasil, principalmente para a busca de casos de tuberculose latente na rotina dos serviços de saúde, por ser um bom instrumento de separação dos indivíduos e não é suficiente para aferir um novo leitor. Entretanto, a régua deverá ser mantida, especialmente para inquéritos epidemiológicos

Introduction- The active search of…

Advisors/Committee Members: Nogueira, Pericles Alves.

Subjects/Keywords: Caliper Rule; Leitura do Teste; Millimeter Ruler; Paquímetro; Reading of the Test; Régua Milimetrada; Teste Tuberculínico; Tuberculin Skin Test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

França, F. A. d. M. (2012). Teste tuberculínico: comparação de dois instrumentos de leitura. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/6/6132/tde-17052012-104258/ ;

Chicago Manual of Style (16^th Edition):

França, Flavia Aparecida de Moraes. “Teste tuberculínico: comparação de dois instrumentos de leitura.” 2012. Doctoral Dissertation, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-17052012-104258/ ;.

MLA Handbook (7^th Edition):

França, Flavia Aparecida de Moraes. “Teste tuberculínico: comparação de dois instrumentos de leitura.” 2012. Web. 27 Feb 2021.

Vancouver:

França FAdM. Teste tuberculínico: comparação de dois instrumentos de leitura. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/6/6132/tde-17052012-104258/ ;.

Council of Science Editors:

França FAdM. Teste tuberculínico: comparação de dois instrumentos de leitura. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/6/6132/tde-17052012-104258/ ;

University of Alberta

23. Kreutz, Valerie Noronha Menezes. Characteristics of immune parameters before and after a single Mantoux test.

Degree: MS, Department of Pediatrics, 1998, University of Alberta

URL: https://era.library.ualberta.ca/files/8k71nk43w

Subjects/Keywords: Blood cells – Research.; Tuberculin test.; Immunology – Research.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kreutz, V. N. M. (1998). Characteristics of immune parameters before and after a single Mantoux test. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/8k71nk43w

Chicago Manual of Style (16^th Edition):

Kreutz, Valerie Noronha Menezes. “Characteristics of immune parameters before and after a single Mantoux test.” 1998. Masters Thesis, University of Alberta. Accessed February 27, 2021. https://era.library.ualberta.ca/files/8k71nk43w.

MLA Handbook (7^th Edition):

Kreutz, Valerie Noronha Menezes. “Characteristics of immune parameters before and after a single Mantoux test.” 1998. Web. 27 Feb 2021.

Vancouver:

Kreutz VNM. Characteristics of immune parameters before and after a single Mantoux test. [Internet] [Masters thesis]. University of Alberta; 1998. [cited 2021 Feb 27]. Available from: https://era.library.ualberta.ca/files/8k71nk43w.

Council of Science Editors:

Kreutz VNM. Characteristics of immune parameters before and after a single Mantoux test. [Masters Thesis]. University of Alberta; 1998. Available from: https://era.library.ualberta.ca/files/8k71nk43w

24. Marathe, Gayatri Jayant. LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/38049

► Background: HIV-infected women have increased risk of reactivation of latent TB infection, making screening crucial. There are limited guidelines for latent TB screening in India.… (more)

▼ Background: HIV-infected women have increased risk of reactivation of latent TB infection, making screening crucial. There are limited guidelines for latent TB screening in India. There is need to study the two available tests, which are known to be compromised in this population - Tuberculin Skin test (TST) and Quantiferon Gold-in-Tube assay (QGIT). Thus, our aim was to evaluate the performance of these two tests in two facilities – Antenatal Clinic (ANC) and Antiretroviral Therapy Center (ARTC). Methodology: We conducted a cross-sectional study of HIV-infected women seeking care at the ANC and ARTC within a government hospital in Pune, India. Trained staff administered sociodemographic/medical history questionnaires before TST and QGIT testing. The percent positivity, percent agreement between tests results and kappa statistic, were calculated. Multivariate logistic regression was used to study risk factors for TST and QGIT positivity. Finally for each test, the number needed to screen (NNS) inorder to avert one TB case, was estimated in each facility. Results: Among ANC participants, 15 (11%) were TST+ and 40 (29 %) were QGIT+, with 73.2 % agreement (95% CI = 63.2-81.4, k = 0.214 (0.04 - 0.39)). Among ARTC participants, 22 (15.1 %) were TST+ and 69 (47.2 %) were QGIT+, with 62.1 % agreement (95% CI = 52-71, k=0.22 (0.09-0.34)). TST-/QGIT+ discordance was common in both groups (21% ANC, 34% ARTC). It was observed in the ANC that NNS estimate is 200 for TST alone and 73 for QGIT alone. Similarly in ARTC TST alone has an NNS of 147 compared to 47 for QGIT alone. Conclusions: The QGIT estimated a higher prevalence of LTBI as compared to TST in both facilities, more comparable to the Revised National TB Control Programme estimate of 30-40 %. Further advantage of using QGIT is the less than half of NNS estimate of TST alone in both settings. Thus there is need for development and evaluation of an algorithm with QGIT alone or two test strategy with both TST and QGIT in these settings, considering the issues with both the tests in this population.

Subjects/Keywords: Latent Tuberculosis infection; HIV infection; Pregnancy; Antenatal Clinic; Anti-retroviral Therapy Center; Tuberculin Skin Test; Interferon gamma release assay

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marathe, G. J. (2014). LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/38049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marathe, Gayatri Jayant. “LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA.” 2014. Thesis, Johns Hopkins University. Accessed February 27, 2021. http://jhir.library.jhu.edu/handle/1774.2/38049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marathe, Gayatri Jayant. “LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA.” 2014. Web. 27 Feb 2021.

Vancouver:

Marathe GJ. LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Feb 27]. Available from: http://jhir.library.jhu.edu/handle/1774.2/38049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marathe GJ. LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/38049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Nadia Grandi Bombonato. Tuberculinização e aspectos epidemiológicos da tuberculose caprina na mesorregião do Triângulo Mineiro e Alto Paranaíba.

Degree: 2009, Federal University of Uberlândia

URL: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2744

►

Dados referentes à tuberculose caprina no Brasil e sua importância em saúde pública são escassos. Diante disso, este trabalho teve por objetivos investigar a ocorrência… (more)

▼

Dados referentes à tuberculose caprina no Brasil e sua importância em saúde pública são escassos. Diante disso, este trabalho teve por objetivos investigar a ocorrência e pesquisar aspectos epidemiológicos da tuberculose em rebanhos leiteiros caprinos na mesorregião do Triângulo Mineiro e Alto Paranaíba, MG. Foram tuberculinizados 233 caprinos provenientes de sete propriedades leiteiras, utilizando-se o teste cervical comparativo, tomando-se como referência os procedimentos e critérios de interpretação de resultados padronizados para esta espécie. Dos animais submetidos ao teste, 1,29% (3/233) reagiram positivamente, 2,14% (5/233) apresentaram reações inconclusivas e 96,57% (225/233) não reagiram. Todos os caprinos positivos e um com resposta inconclusiva foram submetidos à necropsia. Amostras de linfonodos, fígado, pulmão e rim que apresentaram alterações foram colhidos para exame histopatológico (Hematoxilina-Eosina). Material proveniente de abscessos e fragmentos de linfonodos foi submetido à cultura em meio de Stonebrink e Petragnani. Um inquérito epidemiológico foi procedido para análise dos fatores relacionados à ocorrência de tuberculose nas propriedades. Não foram encontradas lesões macroscópicas sugestivas de tuberculose nos animais necropsiados, nem alterações histopatológicas. Também não houve crescimento de micobactérias na cultura. A taxa de reatividade à tuberculina dos caprinos foi de 1,29 %. Por se tratar de rebanhos leiteiros, a ocorrência de tuberculose pode representar risco zoonótico na mesorregião do Triângulo Mineiro e Alto Paranaíba, MG. A interpretação dos registros epidemiológicos, associada aos resultados da tuberculinização constatou reagentes positivos somente na propriedade onde se utilizou leite bovino in natura para alimentar cabritos recém nascidos, porém a ocorrência da tuberculose não pode ser confirmada nesses caprinos.

Data on caprine tuberculosis in Brazil and its importance for public health are scarce. Therefore, the purpose of this study was to investigate the occurrence and examine epidemiological aspects of tuberculosis in dairy goat herds in the Triângulo Mineiro and Alto Paranaíba mesoregion in the state of Minas Gerais, Brazil. Two hundred and thirty-three goats from seven dairy farms were tuberculinized using the comparative cervical tuberculin test, taking as reference the procedures and interpretation criteria of standard results for this species. Of the animals subjected to the test, 1.29% (3/233) reacted positively, 2.14% (5/233) showed inconclusive reactions, and 96.57% (225/233) showed no reaction. All the goats that tested positive and one showing an inconclusive response were necropsied. Samples of lymph nodes, liver, lung and kidney presenting alterations were collected for a histopathological examination (hematoxylin-eosin). Material removed from abscesses and lymph node fragments were cultured in Stonebrink and Petragnani culture media. An epidemiological inquiry was carried out to analyze risk factors on the farms. The necropsied animals did not exhibit…

Advisors/Committee Members: Frederico Ozanam Carneiro e Silva, Paulo Roberto de Oliveira, Flávia Maria Esteves Machado, Eliana Roxo, Anna Monteiro Correia Lima.

Subjects/Keywords: Capra hircus; Caprinos; Mycobacterium bovis; Intradermorreação; Tuberculina; MEDICINA VETERINARIA; Tuberculose em animais; Tuberculose em caprino; Goats; Intradermoreaction; Tuberculin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bombonato, N. G. (2009). Tuberculinização e aspectos epidemiológicos da tuberculose caprina na mesorregião do Triângulo Mineiro e Alto Paranaíba. (Thesis). Federal University of Uberlândia. Retrieved from http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2744

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bombonato, Nadia Grandi. “Tuberculinização e aspectos epidemiológicos da tuberculose caprina na mesorregião do Triângulo Mineiro e Alto Paranaíba.” 2009. Thesis, Federal University of Uberlândia. Accessed February 27, 2021. http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2744.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bombonato, Nadia Grandi. “Tuberculinização e aspectos epidemiológicos da tuberculose caprina na mesorregião do Triângulo Mineiro e Alto Paranaíba.” 2009. Web. 27 Feb 2021.

Vancouver:

Bombonato NG. Tuberculinização e aspectos epidemiológicos da tuberculose caprina na mesorregião do Triângulo Mineiro e Alto Paranaíba. [Internet] [Thesis]. Federal University of Uberlândia; 2009. [cited 2021 Feb 27]. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2744.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bombonato NG. Tuberculinização e aspectos epidemiológicos da tuberculose caprina na mesorregião do Triângulo Mineiro e Alto Paranaíba. [Thesis]. Federal University of Uberlândia; 2009. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2744

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pretoria

26. Macucule, Baltazar Antonio. Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique.

Degree: Veterinary Tropical Diseases, 2010, University of Pretoria

URL: http://hdl.handle.net/2263/22937

► This study was conducted to confirm the presence of bovine tuberculosis (BTB) and determine its prevalence, based on skin test reactivity, in cattle reared under… (more)

▼ This study was conducted to confirm the presence of bovine tuberculosis (BTB) and determine its prevalence, based on skin test reactivity, in cattle reared under extensive farming conditions in the Govuro district, Inhambane province, Mozambique. The study was comprised of a primary screening test using the single intradermal test (SIT) in randomly selected animals from Colonato and Sede dip tanks in Govuro. Positive reactors to the SIT were tested again with bovine and avian tuberculin using the single intradermal comparative test (SICTT) 7 weeks after the SIT. The sample size was calculated using Win Episcope 2.0 based on 95% confidence to detect a 2% expected prevalence using the SIT, with a 1% accepted error and accounting for a total population size of 7208. The calculated sample size was 682 animals. To compensate for the probability of 20% default in reading, the sample size was increased to 853. During the testing process (SIT), it was evident from the first 3 reading days that the apparent prevalence (61, 94%) was higher than expected (2%), hence we decided to stop when the total number of cattle was 530. During the testing process (SIT), it was evident from the first 3 reading days that the apparent prevalence (61.94%) was far higher than expected (2%), hence we decided to stop when the total number of cattle was 530. This was due to the fact that, at such a high prevalence, it would not be necessary to achieve as high a precision as 1% accepted error. A sample size of 530 would be sufficient to achieve a precision of 4% accepted error, which was regarded as more than adequate. The 530 cattle, 3 or more years of age, were selected using systematic random sampling from the two dip tanks (Colonato 371 and Sede 159 animals). All animals were identified by numbers painted, dorsally on the sacral region. Out of 530 tested cattle by SIT, 268 were read, and 166/268 (61.94% with 95% confidence interval [CI]: 55.8 – 67.8%) were found positive, with visible swallow at the injection site. Apparent prevalence (AP) was found to be 61.94% while the true prevalence (TP) was 75.92%. The predictive value of a positive result (PV+) was found to be 87.9%. No significant difference in apparent prevalence between the two areas was detected by Fisher’s exact test (P = 0.11). By SICTT, out of 28 animals positive reactors to SIT, 21 were possible to read, and 13/21 (61.9%; 95% CI: 55.1 – 89.3%) were found positive. A three year old bull, positive reactor to the SIT, was slaughtered, and a detailed post mortem was carried out and organs with visible lesions were collected for further laboratory testing (histopathology, culture and isolation of M. Bovis and PCR). Later on, 30 more positive reactors to the SIT test were slaughtered: 25/30 (83.3%) showed visible lesions compatible with BTB, and total condemnation of carcass was made in 3/25 (12%) due to generalized lesions. The high prevalence rate of skin test positive animals as well as gross lesions and histopathology were confirmed to be BTB by the isolation and identification of… Advisors/Committee Members: Godfroid, Jacques (advisor), Thompson, P.N. (Peter N.) (advisor), Machado, Adelina (advisor).

Subjects/Keywords: BTB; Cattle – Diseases; Mozambique; Bovine tuberculosis; Avian tuberculin; UCTD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Macucule, B. (2010). Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/22937

Chicago Manual of Style (16^th Edition):

Macucule, Baltazar. “Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique.” 2010. Masters Thesis, University of Pretoria. Accessed February 27, 2021. http://hdl.handle.net/2263/22937.

MLA Handbook (7^th Edition):

Macucule, Baltazar. “Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique.” 2010. Web. 27 Feb 2021.

Vancouver:

Macucule B. Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique. [Internet] [Masters thesis]. University of Pretoria; 2010. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2263/22937.

Council of Science Editors:

Macucule B. Study of the prevalence of bovine tuberculosis in Govuro District, Inhambane Province, Mozambique. [Masters Thesis]. University of Pretoria; 2010. Available from: http://hdl.handle.net/2263/22937

27. Vlachou, Garyfalia. Προσδιορισμός δείκτη μυκοβακτηριδιακής μόλυνσης και ετήσιου κινδύνου μόλυνσης στις υγειονομικές περιφέρειες της χώρας.

Degree: 2015, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/35908

►

Tuberculosis is still amongst the most important causes of human morbidity and mortality. The tuberculin skin test is widely used to define the tuberculous infection… (more)

▼

Tuberculosis is still amongst the most important causes of human morbidity and mortality. The tuberculin skin test is widely used to define the tuberculous infection in the community. Serial representative tuberculin surveys demonstrate the trend of the risk of tuberculin infection. The annual risk of Tuberculosis infection (ARTI) is a key indicator in epidemiology, of the extent of transmission in a community. There have been several suggested methods in order to evaluate the prevalence of Tuberculosis infection using tuberculin skin data. This survey estimates the annual risk of Tuberculosis infection (ARTI) in young hellenic men. The effect of BCG vaccination has also been investigated. Materials and Methods: During the period November 2006-November 2007 tuberculin skin tests were conducted to estimate the prevalence of mycobacterium tuberculosis infection and also to determine the ARTI. We used the Mantoux technique with tuberculin PPD–RT 23 with Tween 80, dose 2 IU was used in 7.492 Greek air force military recruits with an average age of 23.57 years. All recruits were examined for previous bacill Calmette-Guérin vaccination through BCG scar. A vast number of personal, epidemiological significance, data of the participants was collected through a specially designed demographic form which was filled in and concerned information regarding their age, geographical birth place and residence, smoking habits, parental occupation, parental and partecipants’ level of education, recent contact with immigrants from high-incidence countries. The ARTI was calculated based on the equation R=1-(1-P)1/a.(R= annual risk of infection, P= prevalence, a= average age.) Results: The ARTI was 0.2%, in those who were not previously BCG vaccinated, and this was derived from a tuberculin skin test cut-off point of 10 mm . There were not any statistically significant differences, neither between urban and rural population concerning the positivity of the tuberculin skin test, nor among the population in recent contact with immigrants from high–incidence countries. Conclusion: The estimated ARTI among young Greek men is 0.2%. This survey demonstrates further decline in the prevalence of TST positivity in young Hellenic enlistees compared to the outcomes of former studies on this population.

Η φυματίωση εξακολουθεί να είναι από τις πιο σημαντικές αιτίες της ανθρώπινης νοσηρότητας και θνησιμότητας . Η δερματική δοκιμασία φυματίνης χρησιμοποιείται ευρέως για τον καθορισμό της φυματιώδους λοίμωξης στην κοινότητα. Επαναλαμβανόμενες έρευνες με την δερμοαντίδραση της φυματίνης καταδεικνύουν την τάση του κινδύνου της φυματικής μόλυνσης. Ο ετήσιος κίνδυνος μόλυνσης (ARTI ) είναι ένας βασικός επιδημιολογικός δείκτης για την έκταση της μετάδοσης της νόσου σε μια κοινότητα . Υπήρξαν αρκετές προτεινόμενες μέθοδοι προκειμένου να αξιολογηθεί ο επιπολασμός της μόλυνσης με δερμοαντίδραση φυματίνης. Αυτή η έρευνα εκτιμά τον ετήσιο κίνδυνο της μόλυνσης ( ARTI ) σε νεαρούς άρρενες Έλληνες ενήλικες. Εξετάστηκε, επίσης, η επίδραση του εμβολιασμού…

Subjects/Keywords: Φυματίωση; Δερμοαντίδραση φυματίνης κατά Mantoux; Επιδημιολογία φυματίωσης; Tuberculosis, Statistical data in Greece; Tuberculin skin test; Epidemiology of tuberculosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vlachou, G. (2015). Προσδιορισμός δείκτη μυκοβακτηριδιακής μόλυνσης και ετήσιου κινδύνου μόλυνσης στις υγειονομικές περιφέρειες της χώρας. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/35908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vlachou, Garyfalia. “Προσδιορισμός δείκτη μυκοβακτηριδιακής μόλυνσης και ετήσιου κινδύνου μόλυνσης στις υγειονομικές περιφέρειες της χώρας.” 2015. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed February 27, 2021. http://hdl.handle.net/10442/hedi/35908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vlachou, Garyfalia. “Προσδιορισμός δείκτη μυκοβακτηριδιακής μόλυνσης και ετήσιου κινδύνου μόλυνσης στις υγειονομικές περιφέρειες της χώρας.” 2015. Web. 27 Feb 2021.

Vancouver:

Vlachou G. Προσδιορισμός δείκτη μυκοβακτηριδιακής μόλυνσης και ετήσιου κινδύνου μόλυνσης στις υγειονομικές περιφέρειες της χώρας. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/35908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vlachou G. Προσδιορισμός δείκτη μυκοβακτηριδιακής μόλυνσης και ετήσιου κινδύνου μόλυνσης στις υγειονομικές περιφέρειες της χώρας. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2015. Available from: http://hdl.handle.net/10442/hedi/35908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oklahoma

28. Dunn, Donald J. Isolation, partial purification, and biological activity of guinea pig leukocytic transfer factor.

Degree: PhD, 1966, University of Oklahoma

URL: http://hdl.handle.net/11244/2075

Subjects/Keywords: Tuberculosis Vaccination.; Tuberculin test.; Tuberculosis Research.; Biology, Microbiology.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dunn, D. J. (1966). Isolation, partial purification, and biological activity of guinea pig leukocytic transfer factor. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/2075

Chicago Manual of Style (16^th Edition):

Dunn, Donald J. “Isolation, partial purification, and biological activity of guinea pig leukocytic transfer factor.” 1966. Doctoral Dissertation, University of Oklahoma. Accessed February 27, 2021. http://hdl.handle.net/11244/2075.

MLA Handbook (7^th Edition):

Dunn, Donald J. “Isolation, partial purification, and biological activity of guinea pig leukocytic transfer factor.” 1966. Web. 27 Feb 2021.

Vancouver:

Dunn DJ. Isolation, partial purification, and biological activity of guinea pig leukocytic transfer factor. [Internet] [Doctoral dissertation]. University of Oklahoma; 1966. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11244/2075.

Council of Science Editors:

Dunn DJ. Isolation, partial purification, and biological activity of guinea pig leukocytic transfer factor. [Doctoral Dissertation]. University of Oklahoma; 1966. Available from: http://hdl.handle.net/11244/2075

29. Σγούντζος, Βασίλειος. Σύγκριση της βιολογικής ισχύος των φυματινών RT23 και Merieux μετά ταυτόχρονη χορήγηση σε μαθητές της Αστυνομικής Ακαδημίας Αθηνών.

Degree: 2008, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/23382

►

Cell mediated immunity and delayed type hypersensitivity play key roles in the pathogenesis of tubersulosis. Infection with M. Tuberculosis results in delayed type hypersensitivity reaction… (more)

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Cell mediated immunity and delayed type hypersensitivity play key roles in the pathogenesis of tubersulosis. Infection with M. Tuberculosis results in delayed type hypersensitivity reaction to antigens derived from the organism, which is the basis of the tuberculin skin test. Tuberculin reaction is a localized skin reaction with typical histological picture, which is the result of the mobilization of delayed hypersensitivity reaction, whenerver mycobacterial products have been injected intradermally. Two types of tuberculin preparation have been in use, old tuberculin and purified protein derivative. Several studies have indicated a considerable variability on the biological results between different tuberculin preparations in different geographical areas or even within a single region. The purpose of this study was to evaluate and compare the biological potency of two different tuberculins, RT23 and Merieux. We performed simultaneous testing with both tuberculins to compare these reagents during a tuberculin survey of 546 Police Academy Students in Athens. The students were separated in three groups and the participants of each group were tested using the mantoux method simultaneously with the two tuberculins in different concentrations. Using a 10mm cut-off point for a positive skin test, the positive reactions with the tuberculins RT23 and Merieux were highly correlated. No statistically significant difference was established. The results indicated significant superiority of the size of the reactions with RT23 tuberculin (p=0,014). It appears that both tuberculins have equivalent potency, with RT23, producing more frequently reactions of larger sizes.

H κυτταρική ανοσία καθώς και η υπερευαισθησία επιβραδυνόμενου τύπου, που αναπτύσσονται μετά την έκθεση στο μυκοβακτηρίδιο της φυματίωσης, έχουν βασικό ρόλο στη παθογένεια της νόσου. Η φυματίνη αποτελεί βιολογικό προϊόν που περιέχει μυκοβακτηριδιακά συστατικά ικανά να διεγείρουν την υπερευαισθησία επιβραδυνόμενου τύπου προς το μυκοβακτηρίδιο ενός ήδη ευαισθητοποιημένου ξενιστή. Οι πρώτες φυματίνες ήταν μη καθαρά προϊόντα που οδηγούσαν σε ψευδώς θετικά αποτελέσματα. Από την περαιτέρω όμως επεξεργασία τους προέκυψαν κεκαθαρμένα παράγωγα απαλλαγμένα από προσμίξεις. Σύμφωνα με διάφορες εργασίες η ίδια φυματίνη μπορεί να έχει διαφορετική αντιγονική διέγερση όταν εφαρμόζεται σε ανόμοιους πληθυσμούς. Για το λόγο αυτό είναι διεθνής πρακτική η χρήση του ιδίου προϊόντος σε ένα πληθυσμό επί μακρόν για πληρέστερη εξοικείωση του ιατρικού προσωπικού. Σκοπός της μελέτης μας ήταν η σύγκριση της βιολογικής ισχύος δύο διαφορετικών φυματινών, των RT23 και Merieux. Οι δύο φυματίνες χορηγήθηκαν σε 546 νεαρά άτομα, σπουδαστές της Αστυνομικής Ακαδημίας Αθηνών, που χωρίσθηκαν σε τρεις ομάδες. Η χορήγηση με τη μέθοδο Mantoux ήταν ταυτόχρονη, κατά ζεύγη και σε διαφορετικές συγκεντρώσεις. Θετική φυματινοαντίδραση θεωρήθηκε διήθηση ?10mm. Έγινε σύγκριση του μεγέθους καθώς και του ποσοστού των θετικών φυματινοαντιδράσεων. Από την ανάλυση των αποτελεσμάτων δεν παρατηρήθηκε στατιστικά σημαντική…

Subjects/Keywords: Φυματίωση; Υπερευαισθησία επιβραδυνόμενου τύπου; Φυματίνες; Φυματίνη RT23; Φυματίνη Merieux; Φυματινοαντίδραση; Βιολογική ισχύς; Βιολογική ισοδυναμία; Tuberculosis; Delayed hypersensitivity reaction; Tuberculins; Tuberculin RT23; Tuberculin Merieux; Tuberculin skin test; Biological potency; Biological equivalence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Σγούντζος, . �. (2008). Σύγκριση της βιολογικής ισχύος των φυματινών RT23 και Merieux μετά ταυτόχρονη χορήγηση σε μαθητές της Αστυνομικής Ακαδημίας Αθηνών. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/23382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Σγούντζος, Βασίλειος. “Σύγκριση της βιολογικής ισχύος των φυματινών RT23 και Merieux μετά ταυτόχρονη χορήγηση σε μαθητές της Αστυνομικής Ακαδημίας Αθηνών.” 2008. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed February 27, 2021. http://hdl.handle.net/10442/hedi/23382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Σγούντζος, Βασίλειος. “Σύγκριση της βιολογικής ισχύος των φυματινών RT23 και Merieux μετά ταυτόχρονη χορήγηση σε μαθητές της Αστυνομικής Ακαδημίας Αθηνών.” 2008. Web. 27 Feb 2021.

Vancouver:

Σγούντζος �. Σύγκριση της βιολογικής ισχύος των φυματινών RT23 και Merieux μετά ταυτόχρονη χορήγηση σε μαθητές της Αστυνομικής Ακαδημίας Αθηνών. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2008. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/23382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Σγούντζος �. Σύγκριση της βιολογικής ισχύος των φυματινών RT23 και Merieux μετά ταυτόχρονη χορήγηση σε μαθητές της Αστυνομικής Ακαδημίας Αθηνών. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2008. Available from: http://hdl.handle.net/10442/hedi/23382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

30. Garziera, Giovana. Prevalência de teste tuberculínico positivo prévio ao uso de imunobiológicos em pacientes reumatológicos.

Degree: 2017, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/158291

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Base teórica: A introdução de agentes biológicos, especialmente os bloqueadores do fator de necrose tumoral (anti-TNF), para o tratamento de doenças reumáticas aumentou o risco… (more)

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Base teórica: A introdução de agentes biológicos, especialmente os bloqueadores do fator de necrose tumoral (anti-TNF), para o tratamento de doenças reumáticas aumentou o risco de desenvolver tuberculose (TB). O rastreio para infecção tuberculosa latente (ILTB) é fortemente recomendado antes de iniciar a terapia com agentes anti-TNF. Os objetivos deste estudo foram identificar a prevalência de ILTB e TB entre pacientes com doenças reumáticas em uso dos medicamentos anti-TNF. Métodos: Estudo transversal. Foram revisados os registros médicos eletrónicos de todos os doentes adultos (≥ 18 anos) em uso da terapia anti-TNF. Todos os pacientes foram submetidos ao teste tuberculínico (TT) antes de iniciar o tratamento com os medicamentos anti-TNF. Resultados: No total, 176 pacientes foram incluídos no estudo. A idade média de todos os pacientes foi de 51,9 ± 12,4 anos, 34,7% eram do sexo masculino e 90,9% eram brancos. As doenças subjacentes mais comuns foram: Artite Reumatóide (AR) em 89 pacientes (50,6%), Espondilite Anquilosante (EA) em 49 (27,8%) e Artrite Psoriática (AP) em 31 (17,6%). A prevalência de TT positivo foi de 29,5%. O contato domiciliar com TB foi significativamente associado com TT positivo (p = 0,020). Os pacientes com AR apresentaram reações TT menores do que os pacientes com EA (p = 0,022). Houve seis casos de TB (3,4%) diagnosticados durante a terapia anti-TNF. Conclusões: Demonstrou-se alta prevalência de TT positivo (29,5%) em pacientes com doenças reumáticas em uma região com alta prevalência de TB. Nossos dados corroboram a recomendação do Colégio Americano de Reumatologia (ACR) de que os pacientes que vivem em configurações de alta incidência de TB devem ser testados anualmente para ILTB.

Background: The introduction of biological agents, especially the blockers of tumor necrosis factor (anti-TNF), for the treatment of rheumatic diseases increased the risk of developing tuberculosis (TB). Screening for latent TB infection (LTBI|) is strongly recommended before starting therapy with anti-TNF agents. The objectives of this study were to identify the prevalence of LTBI and TB among patients with rheumatic diseases on anti-TNF drugs. Methods: Cross-sectional study. The electronic medical records of all adult patients (≥ 18 years old) undergoing anti-TNF treatment were reviewed. Every patient underwent TST test before starting anti-TNF treatment. Results: In total, 176 patients were included in the study. The mean age of all patients was 51.9 ± 12.4 years, 34.7% were males, and 90.9% were white. The most common underlying diseases were: RA in 89 patients (50.6%), AS in 49 (27.8%), and PA in 31 (17.6%). The prevalence of positive TST was 29.5%. Household contact with TB was significantly associated with a positive TST (p=0.020). RA patients had lower TST reactions than AS patients (p=0.022). There were six cases of TB (3.4%) diagnosed during anti-TNF therapy. Conclusions: We demonstrated a high prevalence of positive TST (29.5%) among patients with rheumatic diseases in a region with high TB…

Advisors/Committee Members: Silva, Denise Rossato.

Subjects/Keywords: Latent tuberculosis; Tuberculose latente; Teste tuberculínico; Tuberculin skin test; Mycobacterium tuberculosis; Mantoux; Anti-TNF therapy; Fator de necrose tumoral alfa; Artrite reumatóide; Mycobacterium tuberculosis; Tumor necrosis factor-alpha; Rheumatoid arthritis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garziera, G. (2017). Prevalência de teste tuberculínico positivo prévio ao uso de imunobiológicos em pacientes reumatológicos. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/158291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garziera, Giovana. “Prevalência de teste tuberculínico positivo prévio ao uso de imunobiológicos em pacientes reumatológicos.” 2017. Thesis, Universidade do Rio Grande do Sul. Accessed February 27, 2021. http://hdl.handle.net/10183/158291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garziera, Giovana. “Prevalência de teste tuberculínico positivo prévio ao uso de imunobiológicos em pacientes reumatológicos.” 2017. Web. 27 Feb 2021.

Vancouver:

Garziera G. Prevalência de teste tuberculínico positivo prévio ao uso de imunobiológicos em pacientes reumatológicos. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10183/158291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garziera G. Prevalência de teste tuberculínico positivo prévio ao uso de imunobiológicos em pacientes reumatológicos. [Thesis]. Universidade do Rio Grande do Sul; 2017. Available from: http://hdl.handle.net/10183/158291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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