subject:(Triterpenoid saponins)

University of Hong Kong

1. 甄德全. Studies on triterpenes.

Degree: 1971, University of Hong Kong

URL: http://hdl.handle.net/10722/38065

Subjects/Keywords: Triterpenoid saponins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

甄德全. (1971). Studies on triterpenes. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/38065

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

甄德全. “Studies on triterpenes.” 1971. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/38065.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

甄德全. “Studies on triterpenes.” 1971. Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

甄德全. Studies on triterpenes. [Internet] [Thesis]. University of Hong Kong; 1971. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/38065.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

甄德全. Studies on triterpenes. [Thesis]. University of Hong Kong; 1971. Available from: http://hdl.handle.net/10722/38065

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

2. Ramirez, Christina N. Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis.

Degree: PhD, Pharmacology, Cellular and Molecular, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59145/

►

Non-melanoma skin cancer (NMSC) is the most common cancer in the United States with over 4.0 million new cases diagnosed in 2012. An increase of… (more)

▼

Non-melanoma skin cancer (NMSC) is the most common cancer in the United States with over 4.0 million new cases diagnosed in 2012. An increase of exposure to environmental pollutants and sunlight are among the causative agents of the disease. Ursolic acid (UA), a well-known natural triterpenoid found in abundance in fruit peels, cranberries, and blueberries has been shown to possess beneficial health effects against a multitude of disorders including, cardiovascular, neurological, and oncological disorders. However, epigenetic modulation of UA in skin carcinogenesis is still poorly understood. Increasing evidence suggests epigenetics play an important role in the development and progression of cancer including NMSC. Among its many anti-cancer activities, UA has also been shown to have the ability to modulate epigenetic mechanisms in vitro and thus presents an attractive candidate to target the underlying epigenetic mechanisms of skin carcinogenesis. Preliminary data in our laboratory and that of others points to epigenetic regulation of key genes at the center of UA activities: 1) Skin carcinogenesis is enhanced in Nrf2 (-/-) mice; 2) The expression Nrf2 and its target gene HO-1 is reduced in skin tumors of Nrf2 (+/+) mice; 3) UA inhibits TPA-induced ear edema and tumor promotion; 4) Hypermethylation of the promoter region of Nrf2 resulting in reduced expression and its target genes is closely associated with prostate tumor progression; 5) Dietary phytochemicals epigenetically modify the hypermethylation of the Nrf2 promoter region and inhibit TPA-induced transformation. Based on the aforementioned observations, it was hypothesized UA can suppress skin carcinogenesis, in part, through the epigenetic regulation of Nrf2 signaling. We demonstrated for the first time that UA restores the expression of Nrf2 by demethylating CpG islands in the Nrf2 promoter in mouse epidermal cells resulting in an increase in the expression of cytoprotective detoxifying/antioxidant enzymes and suppression of tumor promoter-induced cell transformation. Furthermore, we demonstrate UA is able to suppress skin carcinogenesis in vivo using a relevant and novel B[a]P/TPA skin carcinogenesis model. The long-term goal of this research is to understand some of the underlying epigenetic mechanisms driving skin carcinogenesis and to develop safe and effective strategies to prevent/treat NMSC using phytochemicals such as UA who possess anti-cancer properties.

Advisors/Committee Members: Cai, Li (chair), Liu, Fang (internal member), Kong, Ah-Ng Tony (internal member), Bertino, Joseph (outside member), School of Graduate Studies.

Subjects/Keywords: Skin – Cancer; Triterpenoid saponins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ramirez, C. N. (2018). Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59145/

Chicago Manual of Style (16^th Edition):

Ramirez, Christina N. “Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis.” 2018. Doctoral Dissertation, Rutgers University. Accessed January 19, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/59145/.

MLA Handbook (7^th Edition):

Ramirez, Christina N. “Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis.” 2018. Web. 19 Jan 2021.

Vancouver:

Ramirez CN. Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Jan 19]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59145/.

Council of Science Editors:

Ramirez CN. Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59145/

University of Hong Kong

3. Li, Man-moon, Paul. Eighteen new pentacyclic triterpenoids and other constituents from twenty two Hong Kong plants.

Degree: 1975, University of Hong Kong

URL: http://hdl.handle.net/10722/35216

Subjects/Keywords: Triterpenoid saponins; Plants - Analysis.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, Man-moon, P. (1975). Eighteen new pentacyclic triterpenoids and other constituents from twenty two Hong Kong plants. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/35216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Man-moon, Paul. “Eighteen new pentacyclic triterpenoids and other constituents from twenty two Hong Kong plants.” 1975. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/35216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Man-moon, Paul. “Eighteen new pentacyclic triterpenoids and other constituents from twenty two Hong Kong plants.” 1975. Web. 19 Jan 2021.

Vancouver:

Li, Man-moon P. Eighteen new pentacyclic triterpenoids and other constituents from twenty two Hong Kong plants. [Internet] [Thesis]. University of Hong Kong; 1975. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/35216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li, Man-moon P. Eighteen new pentacyclic triterpenoids and other constituents from twenty two Hong Kong plants. [Thesis]. University of Hong Kong; 1975. Available from: http://hdl.handle.net/10722/35216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

4. Luk, Kong. Three new C32 triterpenes and other triterpenoids from some Hong Kong plants.

Degree: 1971, University of Hong Kong

URL: http://hdl.handle.net/10722/37516

Subjects/Keywords: Plants - Analysis.; Triterpenoid saponins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Luk, K. (1971). Three new C32 triterpenes and other triterpenoids from some Hong Kong plants. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/37516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Luk, Kong. “Three new C32 triterpenes and other triterpenoids from some Hong Kong plants.” 1971. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/37516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Luk, Kong. “Three new C32 triterpenes and other triterpenoids from some Hong Kong plants.” 1971. Web. 19 Jan 2021.

Vancouver:

Luk K. Three new C32 triterpenes and other triterpenoids from some Hong Kong plants. [Internet] [Thesis]. University of Hong Kong; 1971. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/37516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Luk K. Three new C32 triterpenes and other triterpenoids from some Hong Kong plants. [Thesis]. University of Hong Kong; 1971. Available from: http://hdl.handle.net/10722/37516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

5. 馮文亮. A new triterpene ketol, glochidonol, and other triterpenoids from HongKong species of Euphorbiaceae.

Degree: 1969, University of Hong Kong

URL: http://hdl.handle.net/10722/37705

Subjects/Keywords: Euphorbiaceae.; Glochidonol.; Triterpenoid saponins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

馮文亮. (1969). A new triterpene ketol, glochidonol, and other triterpenoids from HongKong species of Euphorbiaceae. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/37705

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

馮文亮. “A new triterpene ketol, glochidonol, and other triterpenoids from HongKong species of Euphorbiaceae.” 1969. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/37705.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

馮文亮. “A new triterpene ketol, glochidonol, and other triterpenoids from HongKong species of Euphorbiaceae.” 1969. Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

馮文亮. A new triterpene ketol, glochidonol, and other triterpenoids from HongKong species of Euphorbiaceae. [Internet] [Thesis]. University of Hong Kong; 1969. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/37705.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

馮文亮. A new triterpene ketol, glochidonol, and other triterpenoids from HongKong species of Euphorbiaceae. [Thesis]. University of Hong Kong; 1969. Available from: http://hdl.handle.net/10722/37705

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of North Carolina – Greensboro

6. Speen, Adam M. Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity.

Degree: 2013, University of North Carolina – Greensboro

URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=10156

► Evidence suggests oxidative and electrophilic stress as a major factor contributing to the neuronal cell death in neurodegenerative disorders, especially Parkinson's disease (PD). Early depletion… (more)

▼ Evidence suggests oxidative and electrophilic stress as a major factor contributing to the neuronal cell death in neurodegenerative disorders, especially Parkinson's disease (PD). Early depletion in the levels of thiol antioxidant glutathione (GSH), which may lead to generation of reactive oxygen species, is an important biochemical feature of PD. However, whether induction of endogenous antioxidative enzymes by a novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imidazoline) affords protection against oxidative and electrophilic neurocytotoxicity has not been carefully investigated. Retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells are known to possess properties of mature neurons and thus have been widely used in vitro model for the study of neurotoxicity and neuroprotection. In this study, we showed that incubation of retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells with nanomolar concentrations of CDDO-IM (1- 400 nM) for 24 h resulted in significant increased in the levels of reduced glutathione (GSH) and NAD(P)H:quinone oxidoreductase 1 (NQO1), two critical cellular defenses in detoxification of reactive oxygen species and electrophilic quinone molecules. Pretreatment of the cells with CDDO-IM was found to afford remarkable protection against the neurocytotoxicity elicited by 4-hydroxynonenal, 3-morpholinosynonimine hydrochloride, xanthine oxidase/xanthine, and hydrogen peroxide. When studied using Buthionine Sulphoximine (BSO), a known GSH inhibitor, in the presence of acrolein CDDO-IM treatment no longer induces such remarkable protection. Taken together, this study demonstrates for the first time that CDDO-IM potently induces the cellular GSH system and NQO1 in retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells, which is accompanied by dramatically increased resistance of these cells to the damage induced by various neurotoxicants. The results of this study may have important implications for the development of novel neuroprotective strategies. Acrolein is a ubiquitous unsaturated aldehyde product occurring in the combustion of organic matter including exhausts and pollutants. A product of lipid peroxidation, acrolein has been implicated in the pathogenesis of various neurological disorders including Parkinson's disease where acrolein-protein adducts have been observed in post mortem studies. However, limited study has been conducted into potential therapeutic protection against acrolein-induced cytotoxicity in neuronal cells via upregulation of cellular aldehyde-detoxification defenses. In this study we have utilized RA-differentiated human SH-SY5Y neuroblastoma cells to investigate the induction of glutathione (GSH), glutathione-s-transferase (GST), and aldose reductase (AR) by the synthetic triterpenoid 2-Cyano-3,12-dixooleana-1,9-dien-28-imidazolide (CDDO-Im); and the protective effects CDDO-Im mediated antioxidant defenses on acrolein-induced toxicity. Incubation of RA-differentiated SH-SY5Y cells with CDDO-Im… Advisors/Committee Members: Zhenquan Jia (advisor).

Subjects/Keywords: Triterpenoid saponins – Therapeutic use; Antioxidants – Physiological effect; Nervous system – Degeneration; Molecular neurobiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Speen, A. M. (2013). Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity. (Masters Thesis). University of North Carolina – Greensboro. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=10156

Chicago Manual of Style (16^th Edition):

Speen, Adam M. “Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity.” 2013. Masters Thesis, University of North Carolina – Greensboro. Accessed January 19, 2021. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=10156.

MLA Handbook (7^th Edition):

Speen, Adam M. “Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity.” 2013. Web. 19 Jan 2021.

Vancouver:

Speen AM. Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity. [Internet] [Masters thesis]. University of North Carolina – Greensboro; 2013. [cited 2021 Jan 19]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=10156.

Council of Science Editors:

Speen AM. Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity. [Masters Thesis]. University of North Carolina – Greensboro; 2013. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=10156

7. NC DOCKS at The University of North Carolina at Greensboro; Speen, Adam M. Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity.

Degree: 2013, NC Docks

URL: http://libres.uncg.edu/ir/uncg/f/Speen_uncg_0154M_11232.pdf

► Evidence suggests oxidative and electrophilic stress as a major factor contributing to the neuronal cell death in neurodegenerative disorders, especially Parkinson's disease (PD). Early depletion… (more)

▼ Evidence suggests oxidative and electrophilic stress as a major factor contributing to the neuronal cell death in neurodegenerative disorders, especially Parkinson's disease (PD). Early depletion in the levels of thiol antioxidant glutathione (GSH), which may lead to generation of reactive oxygen species, is an important biochemical feature of PD. However, whether induction of endogenous antioxidative enzymes by a novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imidazoline) affords protection against oxidative and electrophilic neurocytotoxicity has not been carefully investigated. Retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells are known to possess properties of mature neurons and thus have been widely used in vitro model for the study of neurotoxicity and neuroprotection. In this study, we showed that incubation of retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells with nanomolar concentrations of CDDO-IM (1- 400 nM) for 24 h resulted in significant increased in the levels of reduced glutathione (GSH) and NAD(P)H:quinone oxidoreductase 1 (NQO1), two critical cellular defenses in detoxification of reactive oxygen species and electrophilic quinone molecules. Pretreatment of the cells with CDDO-IM was found to afford remarkable protection against the neurocytotoxicity elicited by 4-hydroxynonenal, 3-morpholinosynonimine hydrochloride, xanthine oxidase/xanthine, and hydrogen peroxide. When studied using Buthionine Sulphoximine (BSO), a known GSH inhibitor, in the presence of acrolein CDDO-IM treatment no longer induces such remarkable protection. Taken together, this study demonstrates for the first time that CDDO-IM potently induces the cellular GSH system and NQO1 in retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells, which is accompanied by dramatically increased resistance of these cells to the damage induced by various neurotoxicants. The results of this study may have important implications for the development of novel neuroprotective strategies. Acrolein is a ubiquitous unsaturated aldehyde product occurring in the combustion of organic matter including exhausts and pollutants. A product of lipid peroxidation, acrolein has been implicated in the pathogenesis of various neurological disorders including Parkinson's disease where acrolein-protein adducts have been observed in post mortem studies. However, limited study has been conducted into potential therapeutic protection against acrolein-induced cytotoxicity in neuronal cells via upregulation of cellular aldehyde-detoxification defenses. In this study we have utilized RA-differentiated human SH-SY5Y neuroblastoma cells to investigate the induction of glutathione (GSH), glutathione-s-transferase (GST), and aldose reductase (AR) by the synthetic triterpenoid 2-Cyano-3,12-dixooleana-1,9-dien-28-imidazolide (CDDO-Im); and the protective effects CDDO-Im mediated antioxidant defenses on acrolein-induced toxicity. Incubation of RA-differentiated SH-SY5Y cells with CDDO-Im…

Subjects/Keywords: Triterpenoid saponins $x Therapeutic use; Antioxidants $x Physiological effect; Nervous system $x Degeneration; Molecular neurobiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Speen, A. M. (2013). Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity. (Thesis). NC Docks. Retrieved from http://libres.uncg.edu/ir/uncg/f/Speen_uncg_0154M_11232.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Speen, Adam M. “Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity.” 2013. Thesis, NC Docks. Accessed January 19, 2021. http://libres.uncg.edu/ir/uncg/f/Speen_uncg_0154M_11232.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Speen, Adam M. “Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity.” 2013. Web. 19 Jan 2021.

Vancouver:

NC DOCKS at The University of North Carolina at Greensboro; Speen AM. Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity. [Internet] [Thesis]. NC Docks; 2013. [cited 2021 Jan 19]. Available from: http://libres.uncg.edu/ir/uncg/f/Speen_uncg_0154M_11232.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

NC DOCKS at The University of North Carolina at Greensboro; Speen AM. Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity. [Thesis]. NC Docks; 2013. Available from: http://libres.uncg.edu/ir/uncg/f/Speen_uncg_0154M_11232.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

8. Ko, Dip-shin, Phyllis. Triterpenoid and other constituents from the leaves of some Castanopsis and Lithocarpus species of the Hong Kong Fagaceae.

Degree: 1972, University of Hong Kong

URL: http://hdl.handle.net/10722/35041

Subjects/Keywords: Plants - Analysis.; Lithocarpus.; Castanopsis.; Triterpenoid saponins

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ko, Dip-shin, P. (1972). Triterpenoid and other constituents from the leaves of some Castanopsis and Lithocarpus species of the Hong Kong Fagaceae. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/35041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ko, Dip-shin, Phyllis. “Triterpenoid and other constituents from the leaves of some Castanopsis and Lithocarpus species of the Hong Kong Fagaceae.” 1972. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/35041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ko, Dip-shin, Phyllis. “Triterpenoid and other constituents from the leaves of some Castanopsis and Lithocarpus species of the Hong Kong Fagaceae.” 1972. Web. 19 Jan 2021.

Vancouver:

Ko, Dip-shin P. Triterpenoid and other constituents from the leaves of some Castanopsis and Lithocarpus species of the Hong Kong Fagaceae. [Internet] [Thesis]. University of Hong Kong; 1972. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/35041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ko, Dip-shin P. Triterpenoid and other constituents from the leaves of some Castanopsis and Lithocarpus species of the Hong Kong Fagaceae. [Thesis]. University of Hong Kong; 1972. Available from: http://hdl.handle.net/10722/35041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

9. Xu, Yang. Proteomic and biochemical characterization of the anti-cancer mechanism of tubeimoside-1 extracted from the Chinese herbalmedicine "Tu bei mu".

Degree: 2010, University of Hong Kong

URL: http://hdl.handle.net/10722/133475

Subjects/Keywords: Antineoplastic agents.; Cucurbitaceae - Physiological effect.; Triterpenoid saponins.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xu, Y. (2010). Proteomic and biochemical characterization of the anti-cancer mechanism of tubeimoside-1 extracted from the Chinese herbalmedicine "Tu bei mu". (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/133475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xu, Yang. “Proteomic and biochemical characterization of the anti-cancer mechanism of tubeimoside-1 extracted from the Chinese herbalmedicine "Tu bei mu".” 2010. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/133475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xu, Yang. “Proteomic and biochemical characterization of the anti-cancer mechanism of tubeimoside-1 extracted from the Chinese herbalmedicine "Tu bei mu".” 2010. Web. 19 Jan 2021.

Vancouver:

Xu Y. Proteomic and biochemical characterization of the anti-cancer mechanism of tubeimoside-1 extracted from the Chinese herbalmedicine "Tu bei mu". [Internet] [Thesis]. University of Hong Kong; 2010. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/133475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xu Y. Proteomic and biochemical characterization of the anti-cancer mechanism of tubeimoside-1 extracted from the Chinese herbalmedicine "Tu bei mu". [Thesis]. University of Hong Kong; 2010. Available from: http://hdl.handle.net/10722/133475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

10. 陳偉成. Two new C32 triterpenes and other triterpenoids from Hong Kong plants.

Degree: 1973, University of Hong Kong

URL: http://hdl.handle.net/10722/37986

Subjects/Keywords: Plants - Analysis.; Triterpenoid saponins.; Botany - China - Hong Kong.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

陳偉成. (1973). Two new C32 triterpenes and other triterpenoids from Hong Kong plants. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/37986

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

陳偉成. “Two new C32 triterpenes and other triterpenoids from Hong Kong plants.” 1973. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/37986.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

陳偉成. “Two new C32 triterpenes and other triterpenoids from Hong Kong plants.” 1973. Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

陳偉成. Two new C32 triterpenes and other triterpenoids from Hong Kong plants. [Internet] [Thesis]. University of Hong Kong; 1973. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/37986.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

陳偉成. Two new C32 triterpenes and other triterpenoids from Hong Kong plants. [Thesis]. University of Hong Kong; 1973. Available from: http://hdl.handle.net/10722/37986

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

11. Kougan Nkwokap, Guy Beddos. Isolement et caractérisation des saponosides de trois plantes de la famille des araliaceae et dracaenaceae et évaluation de leurs activités cytotoxiques sur cellules tumorales : Isolation and caracterisation of saponins from three plants of Araliaceae and Dracaenaceae families and evaluation of their cytotoxic activities on tumoral cells.

Degree: Docteur es, Pharmacie, 2010, Dijon; Université de Yaoundé I. Département de chimie organique

URL: http://www.theses.fr/2010DIJOPE01

►

L’intérêt des substances d’origine naturelle, potentiellement anti-tumorales nous a amené à nous intéresser aux saponines triterpéniques et stéroïdiques de plantes issues de la biodiversité africaine… (more)

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L’intérêt des substances d’origine naturelle, potentiellement anti-tumorales nous a amené à nous intéresser aux saponines triterpéniques et stéroïdiques de plantes issues de la biodiversité africaine de la famille des Araliaceae et des Dracaenaceae. En effet, des études antérieures menées sur quelques plantes de ces deux familles ont conduit à l’obtention de molécules complexes et originales possédant d’excellentes propriétés cytotoxiques, immuno-modulatrices, anti-inflammatoires. Au vu de ces résultats nous avons entrepris des investigations pharmaco-chimiques sur Cussonia arborea (Araliaceae), Dracaena deisteliana et Dracaena arborea (Dracaenaceae), plantes médicinales couramment utilisées en pharmacopée traditionnelle africaine pour traiter différentes maladies. Les travaux menés ont conduit à l’isolement de 31 composés purs en utilisant les différentes techniques analytiques du laboratoire notamment les diverses techniques de chromatographie liquide successive à pression atmosphérique, moyenne pression et flash chromatographie sur silice en phase normale et en phase inverse. Les structures ont été déterminées par les méthodes de spectrométrie de masse en source FAB et de spectroscopie de RMN 1D et 2D (COSY, TOCSY, NOESY, HMBC et HSQC). Parmi les 07 composés purs obtenus des écorces de Cussonia arborea, 5 sont des nouvelles saponines triterpéniques dont un dérivé de l’acide ursolique, un dérivé de l’hédéragénine et trois dérivés de l’acide oléanolique, tous disubstitués en position 3 et 28 par des chaînes oligosaccharidiques. 13 composés purs sont obtenus à partir des feuilles de Cussonia arborea, dont 7 nouvelles saponines triterpéniques dérivés de l’acide ursolique, de l’acide 23-hydroxyursolique, de l’hédéragénine et de l’acide oléanolique dont 04 d’entre elles sont obtenues sous forme de mélanges inséparables d’isomères acide oléanolique/acide ursolique et hédéragénine/acide 23-hydroxyursolique. A partir des écorces de Dracaena arborea et des tiges de Dracaena deisteliana, nous avons isolé et caractérisé 10 saponines stéroïdiques dont 4 nouvelles et une sapogénine. Les activités de certains de ces produits purs ont été évaluées sur deux lignées de cellules cancéreuses coliques humaines HCT 116 et HT-29.

The interest of the substances from natural origin, potentially antitumor led us to interest in triterpenoid and steroidal saponins of plants from the African biodiversity belonging to the Araliaceae and Dracaenaceae families of plants. Indeed, of the former studies undertaken on some plants of these two families led to obtaining complex and original molecules having excellent cytotoxic, immuno-modulating, anti-inflammatory properties. Within sight of these results we undertook pharmaco-chemical investigations on Cussonia arborea (Araliaceae), Dracaena deisteliana, and Dracaena arborea (Dracaenaceae), medicinal plants usually used in african traditional pharmacopeia to treat various diseases. The work led to the isolation of 31 pure compounds by using the various analytical techniques in particular the…

Advisors/Committee Members: Lacaille-Dubois, Marie-Aleth (thesis director), Sondengam, Beibam Lucas (thesis director).

Subjects/Keywords: Araliaceae; Dracaenaceae; Cussonia arborea; Dracaena arborea; Dracaena deisteliana; Saponines triterpéniques; Saponines stéroïdiques; Cytotoxicité; Araliaceae; Dracaenaceae; Cussonia arborea; Dracaena arborea; Dracaena deisteliana; Triterpenoid saponins; Steroidal saponins; Cytotoxicity; 615.3; 615.1; 547

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kougan Nkwokap, G. B. (2010). Isolement et caractérisation des saponosides de trois plantes de la famille des araliaceae et dracaenaceae et évaluation de leurs activités cytotoxiques sur cellules tumorales : Isolation and caracterisation of saponins from three plants of Araliaceae and Dracaenaceae families and evaluation of their cytotoxic activities on tumoral cells. (Doctoral Dissertation). Dijon; Université de Yaoundé I. Département de chimie organique. Retrieved from http://www.theses.fr/2010DIJOPE01

Chicago Manual of Style (16^th Edition):

Kougan Nkwokap, Guy Beddos. “Isolement et caractérisation des saponosides de trois plantes de la famille des araliaceae et dracaenaceae et évaluation de leurs activités cytotoxiques sur cellules tumorales : Isolation and caracterisation of saponins from three plants of Araliaceae and Dracaenaceae families and evaluation of their cytotoxic activities on tumoral cells.” 2010. Doctoral Dissertation, Dijon; Université de Yaoundé I. Département de chimie organique. Accessed January 19, 2021. http://www.theses.fr/2010DIJOPE01.

MLA Handbook (7^th Edition):

Kougan Nkwokap, Guy Beddos. “Isolement et caractérisation des saponosides de trois plantes de la famille des araliaceae et dracaenaceae et évaluation de leurs activités cytotoxiques sur cellules tumorales : Isolation and caracterisation of saponins from three plants of Araliaceae and Dracaenaceae families and evaluation of their cytotoxic activities on tumoral cells.” 2010. Web. 19 Jan 2021.

Vancouver:

Kougan Nkwokap GB. Isolement et caractérisation des saponosides de trois plantes de la famille des araliaceae et dracaenaceae et évaluation de leurs activités cytotoxiques sur cellules tumorales : Isolation and caracterisation of saponins from three plants of Araliaceae and Dracaenaceae families and evaluation of their cytotoxic activities on tumoral cells. [Internet] [Doctoral dissertation]. Dijon; Université de Yaoundé I. Département de chimie organique; 2010. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2010DIJOPE01.

Council of Science Editors:

Kougan Nkwokap GB. Isolement et caractérisation des saponosides de trois plantes de la famille des araliaceae et dracaenaceae et évaluation de leurs activités cytotoxiques sur cellules tumorales : Isolation and caracterisation of saponins from three plants of Araliaceae and Dracaenaceae families and evaluation of their cytotoxic activities on tumoral cells. [Doctoral Dissertation]. Dijon; Université de Yaoundé I. Département de chimie organique; 2010. Available from: http://www.theses.fr/2010DIJOPE01

Georgia Tech

12. Cohen, Staci Padove. Functional identification and initial characterization of a fish co-receptor involved in aversive signaling.

Degree: PhD, Biology, 2009, Georgia Tech

URL: http://hdl.handle.net/1853/29677

► Chemoreception plays an important role in predator-prey interactions and feeding dynamics. While the chemoreception of attractant or pleasant tasting compounds has been well studied, aversive… (more)

▼ Chemoreception plays an important role in predator-prey interactions and feeding dynamics. While the chemoreception of attractant or pleasant tasting compounds has been well studied, aversive chemoreceptive signaling has been difficult to investigate behaviorally in an ecological context because these interactions are species- and context- specific and deterrent compounds vary among prey. Using the coral reef system, this thesis explores on a molecular level the deterrent mechanism underlying detection by fish predators of an aversive compound, in order to gain a greater understanding of predator-prey interactions in this community. Like other organisms that are sessile or slow-moving, marine sponges have special mechanisms for defense from predation, commonly containing aversive-tasting compounds that defend these organisms from predation. To this end, we sought to identify and characterize a fish chemoreceptor that detects one or more of these compounds. We isolated a single cDNA clone encoding RAMP-like triterpene glycoside receptor (RL-TGR), a novel co-receptor involved in the signaling of triterpene glycosides. This co-receptor appears to be structurally and functionally related to receptor activity-modifying proteins (RAMPs), a family of co-receptors that physically associate with and modify the activity of G protein-coupled receptors (GPCRs). Expression in Xenopus oocytes showed that it responds to triterpene glycosides in a receptor-mediated manner and requires co-expression of a GPCR to enable signaling in oocytes; both of these receptors may be components of a larger signaling complex. A 40 bp portion of the gene is conserved across multiple fish species, but is not found in any other organism with a sequenced genome, suggesting that the expression of this receptor is limited to fish species. RL-TGR is the first identified gene encoding a co-receptor that responds to a chemical defense. This finding may lead the way for the identification of many other receptors that mediate chemical defense signaling in both marine and terrestrial environments, as this protein has the potential to represent the first of an entire family of co-receptors that respond to aversive compounds. Advisors/Committee Members: McCarty, Nael A. (Committee Chair), Kubanek, Julia (Committee Co-Chair), Derby, Charles (Committee Member), Goodisman, Michael (Committee Member), Pardue, Machelle (Committee Member), Weissburg, Marc (Committee Member).

Subjects/Keywords: Chemical defense; Chemical ecology; Chemoreception; Taste receptor; Fish; Marine sponges; Chemical senses; Chemoreceptors; Taste buds; Predation (Biology); Triterpenoid saponins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cohen, S. P. (2009). Functional identification and initial characterization of a fish co-receptor involved in aversive signaling. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/29677

Chicago Manual of Style (16^th Edition):

Cohen, Staci Padove. “Functional identification and initial characterization of a fish co-receptor involved in aversive signaling.” 2009. Doctoral Dissertation, Georgia Tech. Accessed January 19, 2021. http://hdl.handle.net/1853/29677.

MLA Handbook (7^th Edition):

Cohen, Staci Padove. “Functional identification and initial characterization of a fish co-receptor involved in aversive signaling.” 2009. Web. 19 Jan 2021.

Vancouver:

Cohen SP. Functional identification and initial characterization of a fish co-receptor involved in aversive signaling. [Internet] [Doctoral dissertation]. Georgia Tech; 2009. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1853/29677.

Council of Science Editors:

Cohen SP. Functional identification and initial characterization of a fish co-receptor involved in aversive signaling. [Doctoral Dissertation]. Georgia Tech; 2009. Available from: http://hdl.handle.net/1853/29677

13. 王, 麗艶. Studies on the Natural Products with Multi Drug Resistant Cancer Reversal Activity : 耐性癌克服活性を有する天然有機化合物に関する研究.

Degree: Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/7661

新潟大学

平成20年3月24日

新大院博(工)甲第265号

Subjects/Keywords: Triterpenoid Saponins; Extraction; Isolation; Taxoid; Resistant Cancer Reversal Activity; トリテルペンサポニン; 抽出; 分離; タキソイド; 耐性癌克服活性

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

王, �. (n.d.). Studies on the Natural Products with Multi Drug Resistant Cancer Reversal Activity : 耐性癌克服活性を有する天然有機化合物に関する研究. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/7661

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

王, 麗艶. “Studies on the Natural Products with Multi Drug Resistant Cancer Reversal Activity : 耐性癌克服活性を有する天然有機化合物に関する研究.” Thesis, Niigata University / 新潟大学. Accessed January 19, 2021. http://hdl.handle.net/10191/7661.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

王, 麗艶. “Studies on the Natural Products with Multi Drug Resistant Cancer Reversal Activity : 耐性癌克服活性を有する天然有機化合物に関する研究.” Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

王 �. Studies on the Natural Products with Multi Drug Resistant Cancer Reversal Activity : 耐性癌克服活性を有する天然有機化合物に関する研究. [Internet] [Thesis]. Niigata University / 新潟大学; [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10191/7661.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

王 �. Studies on the Natural Products with Multi Drug Resistant Cancer Reversal Activity : 耐性癌克服活性を有する天然有機化合物に関する研究. [Thesis]. Niigata University / 新潟大学; Available from: http://hdl.handle.net/10191/7661

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

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Open Access Theses and Dissertations