subject:(Transfusion)

University of Zambia

1. Mwale, Abel. The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia .

Degree: 2016, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4722

► In low-and middle-income countries (LMICs) the maintenance of standards relating to the transport and storage of blood may be more difficult to achieve. Bacteria contamination… (more)

Subjects/Keywords: Blood – Transfusion

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APA (6^th Edition):

Mwale, A. (2016). The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mwale, Abel. “The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia .” 2016. Thesis, University of Zambia. Accessed April 10, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mwale, Abel. “The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia .” 2016. Web. 10 Apr 2021.

Vancouver:

Mwale A. The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia . [Internet] [Thesis]. University of Zambia; 2016. [cited 2021 Apr 10]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mwale A. The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia . [Thesis]. University of Zambia; 2016. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ottawa

2. Perelman, Iris. The Epidemiology of Multiple Blood Component Transfusion .

Degree: 2019, University of Ottawa

URL: http://hdl.handle.net/10393/38867

► Multicomponent transfusion, or the transfusion of two or more different blood products, has been poorly studied to date, as most of the existing literature has… (more)

▼ Multicomponent transfusion, or the transfusion of two or more different blood products, has been poorly studied to date, as most of the existing literature has focused on the use of individual blood products. This is of concern as multicomponent transfusion recipients likely differ with respect to characteristics and health outcomes from patients transfused with only one type of blood component (e.g. greater illness severity). Consequently, available data on individual blood product use and outcomes may not be applicable to multicomponent transfused patients. This thesis project identified and synthesized existing literature on the epidemiology of multicomponent transfusion in hospital inpatients, as well as the characteristics and outcomes of its recipients. Based on 37 observational studies, we found that the prevalence of multicomponent transfusion varied greatly by patient population, transfusion timeframe, and type of multicomponent transfusion being studied. The most common types of multicomponent transfusion across the 37 studies were co-transfusions of red blood cells (RBCs) and platelets, and co-transfusions of RBCs and plasma. Multicomponent transfusion was found to be associated with several negative health outcomes, however this was based on low quality evidence due to lack of control for confounding by indication. Our systematic review on multicomponent transfusion identified several knowledge gaps, including the need for studies focusing on patients with hematological malignancies, and studies identifying patient characteristics predictive of multicomponent transfusion. To address areas of knowledge deficiency, and to characterize multicomponent transfusion locally at our own center, we designed and conducted a retrospective cohort study of adult, transfused hospital inpatients. Based on 55,719 transfused inpatient admissions at the Ottawa Hospital between 2007 and 2017, we calculated the overall prevalence of multicomponent transfusion to be 25.1% (95% CI: 24.7%, 25.5%). Similar to the findings of our systematic review, the prevalence varied greatly by patient type, transfusion timeframe, and type of multicomponent transfusion. In particular, in hematology patients, the prevalence of multicomponent transfusion was 51%. Other patient groups frequently receiving multicomponent transfusions at our institution were cardiac surgery, critical care, cardiology, vascular surgery, trauma, surgery, and internal medicine patients. Using multivariable regression analysis, we found that patient sex, age, and type were predictive of multicomponent transfusion requirement. Additionally, controlling for illness severity and burden, multicomponent transfusion was associated with increased odds of in-hospital mortality, institutional discharge compared to discharge home, and greater length of hospital stay compared to patients transfused with only RBCs. Given our findings that multicomponent transfusion recipients make up a large proportion of transfused hospital patients, and that they have poorer outcomes, it is of…

Subjects/Keywords: Blood transfusion; Epidemiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Perelman, I. (2019). The Epidemiology of Multiple Blood Component Transfusion . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/38867

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Perelman, Iris. “The Epidemiology of Multiple Blood Component Transfusion .” 2019. Thesis, University of Ottawa. Accessed April 10, 2021. http://hdl.handle.net/10393/38867.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Perelman, Iris. “The Epidemiology of Multiple Blood Component Transfusion .” 2019. Web. 10 Apr 2021.

Vancouver:

Perelman I. The Epidemiology of Multiple Blood Component Transfusion . [Internet] [Thesis]. University of Ottawa; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10393/38867.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Perelman I. The Epidemiology of Multiple Blood Component Transfusion . [Thesis]. University of Ottawa; 2019. Available from: http://hdl.handle.net/10393/38867

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Victoria University of Wellington

3. Atan, Edinur Hisham. Molecular approaches to tissue transplantation and transfusion medicine in Maori and Polynesians in New Zealand.

Degree: 2013, Victoria University of Wellington

URL: http://hdl.handle.net/10063/2987

► My thesis is focused on using new and existing molecular technologies to survey immune system (i.e. HLA, KIR and MICA), blood group and HPA genes… (more)

▼ My thesis is focused on using new and existing molecular technologies to survey immune system (i.e. HLA, KIR and MICA), blood group and HPA genes in Polynesian and Maori subjects. I have compiled large datasets for these individuals including first ever molecular typing blood group, HPA and MICA. I have also compared my data with those from previous genetic studies of KIR and HLA for the four Polynesian sub-populations and HLA for Maori. Combined with previous information in a small scale meta-analysis, the results presented here were interpreted for the first time in the light of new theories about the hybrid origin of Proto-Polynesians via gender-biased gene flow between Austronesian-speaking Mongoloids and Papuan-speaking Australoids. Phylogenetic and principal component/coordinate analyses show that Polynesian sub-populations are closer to each other and are end populations of the great Austronesian Diaspora. Estimation based on HLA class I and II allele frequencies show a wide range (55:45 to 90:10) of ASM:P-SA ancestral fractions in Maori and other Polynesians. The same phenomenon was observed for blood group, HPA and KIR data. Thus, findings from the present study generally support the account deduced from Y-chromosome, mtDNA and genome wide SNP data, and are in accord with the emergent picture from linguistics and archaeology studies. The data collected bear more or less directly on questions of health including tissue matching for transfusion and transplant surgery, disease resistance and the relative incidence of autoimmune disease in these ethnic groups. Tissue matching of HLA, MICA, KIR, blood group and HPA is a fundamental element in transfusion and transplant surgery and it is vital that these technologies take accurate account of the ethnic origins of both donors and recipients. This is important due to significant differences between Polynesians and people of European origin, who form the majority segment of the modern day multi-ethnic country of New Zealand. The prevalence of HLA, MICA, KIR, blood group and HPA and their potential influence on the health of modern day Maori and Polynesians were also discussed. This study was intentionally designed to validate new molecular blood group and HPA typing methods in Polynesian and Maori populations. Scores for the other loci are based on the application of pre-existing technologies. Validation using three different blood group and HPA genotyping methods (i.e. PCR-SSP, SBT and SNP assay) gave 100% concordance and thus reflects the accuracy of the new DNA-based methods. Overall, molecular genotyping does seem to offer the opportunity to improve the efficiency of high quality transfusion services, but should include all known variants that are associated with serological expression. In conclusion, the present molecular genetics study has successfully compiled new HLA, MICA, blood groups, HPA and KIR datasets for Polynesians and Maori, used the datasets for dual analyses of ancestry and health, and demonstrated the reliability of current genotyping… Advisors/Committee Members: Chambers, Geoff.

Subjects/Keywords: Maori; Transfusion; Transplantation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Atan, E. H. (2013). Molecular approaches to tissue transplantation and transfusion medicine in Maori and Polynesians in New Zealand. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/2987

Chicago Manual of Style (16^th Edition):

Atan, Edinur Hisham. “Molecular approaches to tissue transplantation and transfusion medicine in Maori and Polynesians in New Zealand.” 2013. Doctoral Dissertation, Victoria University of Wellington. Accessed April 10, 2021. http://hdl.handle.net/10063/2987.

MLA Handbook (7^th Edition):

Atan, Edinur Hisham. “Molecular approaches to tissue transplantation and transfusion medicine in Maori and Polynesians in New Zealand.” 2013. Web. 10 Apr 2021.

Vancouver:

Atan EH. Molecular approaches to tissue transplantation and transfusion medicine in Maori and Polynesians in New Zealand. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10063/2987.

Council of Science Editors:

Atan EH. Molecular approaches to tissue transplantation and transfusion medicine in Maori and Polynesians in New Zealand. [Doctoral Dissertation]. Victoria University of Wellington; 2013. Available from: http://hdl.handle.net/10063/2987

University of Zambia

4. Siamuyoba, Lawrence S. Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/1391

► To determine the incidence, common indications,appropriateness and outcome of blood transfusions and blood products among adult in-patients admitted to the University teaching Hospital, Lusaka, Zambia.… (more)

▼ To determine the incidence, common indications,appropriateness and outcome of blood transfusions and blood products among adult in-patients admitted to the University teaching Hospital, Lusaka, Zambia. Prospective observational study over a period of 90 days.The university Teaching Hospital and the Zambia National Blood Transfusion Services.Indications for blood transfusion, number of units prescribed and given, the age and sex of the transfusion recipients.All adult patients who received blood transfusion during the period of the study. Data collected by research assistant.Of the 378 requests for blood transfusion we followed up 149 such patients. These received at total of 271 units of blood. 75[27.6%] of the units were given to medical patients, 87[32.17o] to surgical patients and 113[41.3%] to patients from the department of obstetrics and Gynaecology. Females got twice as much blood as males, 67.3% compared to the male with only 32.7%. Most of the blood transfusions were given to patients between the ages of 23 and 42, receiving a total of 74% of the units of blood. 63% of these are less than 30 years of age. The most common indication for blood transfusion was indicated only as anemia. Up to 98% of patient receiving blood transfusion did not have hemoglobin done prior to transfusion. In the university teaching hospital of Lusaka,Zambia, more blood is used mainly in the department of obstetric and gynecology. It can also be concluded that demand for blood products is higher younger patients. It was observed that the use of blood and blood products is inappropriate in most cases as blood was given based on the clinical presence of pallor as a measure of anaemia.it is recommended that blood prescribers acquaint themselves with existing guidelines to avoid indiscriminate use of blood products. Careful evaluation of the risks and potential benefits of transfusion is required. All anemia, except in cases where it is life threatening, should be investigated adequately. Blood transfusion is no substitute for finding the cause of anaemia.

Subjects/Keywords: Blood – Transfusion; Blood – Products

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siamuyoba, L. S. (2012). Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siamuyoba, Lawrence S. “Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital .” 2012. Thesis, University of Zambia. Accessed April 10, 2021. http://hdl.handle.net/123456789/1391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siamuyoba, Lawrence S. “Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital .” 2012. Web. 10 Apr 2021.

Vancouver:

Siamuyoba LS. Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital . [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/123456789/1391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siamuyoba LS. Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

5. Muyoba, Peter. An ethical assessment of the relationship between the Church and the State: A case of blood transfusion among the Jehova's witnesses of Mpika and Lusaka Districts .

Degree: 2015, University of Zambia

URL: http://hdl.handle.net/123456789/4139

► The Watchtower sect, just like other universal religions, makes a strong claim on its members that they refuse blood transfusion as a fundamental part of… (more)

▼ The Watchtower sect, just like other universal religions, makes a strong claim on its members that they refuse blood transfusion as a fundamental part of their belief that God views blood as representing life. Thus it is important to note that commitment to religious beliefs will sometimes inevitably come into conflict with the role of the State, say to provide security and welfare to its members especially vulnerable ones like children. The lives of many Witnesses in Zambia may be at risk due to their unwillingness to undergo blood transfusion on religious grounds. This state of affairs places the Zambian Government in a dilemma as it has a constitutional duty to both respect people‟s religious rights and protect people‟s right to life. The aim of this research is to ethically assess the relationship between the Church and the State on blood transfusion among the Jehovah‟s Witnesses of Mpika and Lusaka districts. The objectives of the study were : (i) to investigate the nature of the doctrinal position of the Jehovah‟s Witnesses in Mpika and Lusaka on the rejection of blood transfusion; (ii) to explore the extent to which Jehovah‟s Witnesses of Mpika and Lusaka share in the doctrinal position on the rejection of blood transfusion; (iii) to ascertain the awareness of Jehovah‟s Witnesses of Mpika and Lusaka about the benefits and burdens of rejecting blood transfusion in Zambia; and, (iv) to examine the position of the State on the rejection of blood transfusion by Jehovah‟s Witnesses. A total of 30 persons were interviewed. This number was sufficient for the study as it was supplemented by two focus group discussions among medical students at UNZA Ridgeway Campus and seven focus group discussions among Jehovah‟s Witnesses at all Kingdom Halls under study. The significance of the study highlights the ethical challenge that the Watchtower doctrine on blood transfusion presents to the relationship between the Church and the State. The research design was a case study. The study used a qualitative approach which involved an ethical assessment. The methods employed were in-depth interviews and focus group discussions. The ethical framework of the study used to collect relevant data and inform the ethical assessment of the study included Rights theory and different ethical principles which comprised the principle of beneficence, the principle of nonmaleficence, the principle of autonomy and the principle of paternalism. The study made the following recommendations: (i) the autonomy of a competent patient should be respected by medical practitioners if they refuse blood transfusion on religious grounds; (ii) the State should ensure that alternatives to blood transfusion are made available in hospitals and clinics so that patients have options to choose from ; (iii) the State should provide medical institutions with well trained personnel that minimize the possibility of blood loss; (iv) Medical practitioners should maintain frequent and close surveillance for signs and symptoms of postpartum to facilitate early…

Subjects/Keywords: Church and State; Blood transfusion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Muyoba, P. (2015). An ethical assessment of the relationship between the Church and the State: A case of blood transfusion among the Jehova's witnesses of Mpika and Lusaka Districts . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/4139

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Muyoba, Peter. “An ethical assessment of the relationship between the Church and the State: A case of blood transfusion among the Jehova's witnesses of Mpika and Lusaka Districts .” 2015. Thesis, University of Zambia. Accessed April 10, 2021. http://hdl.handle.net/123456789/4139.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Muyoba, Peter. “An ethical assessment of the relationship between the Church and the State: A case of blood transfusion among the Jehova's witnesses of Mpika and Lusaka Districts .” 2015. Web. 10 Apr 2021.

Vancouver:

Muyoba P. An ethical assessment of the relationship between the Church and the State: A case of blood transfusion among the Jehova's witnesses of Mpika and Lusaka Districts . [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/123456789/4139.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Muyoba P. An ethical assessment of the relationship between the Church and the State: A case of blood transfusion among the Jehova's witnesses of Mpika and Lusaka Districts . [Thesis]. University of Zambia; 2015. Available from: http://hdl.handle.net/123456789/4139

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Dama, Swarupa Basavraj. Survey of blood transfusion-induced malaria and other diseases in thalassemia patients from Solapur District (M.S.) India; -.

Degree: Zoology, 2012, Dr. Babasaheb Ambedkar Marathwada University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13688

►

Thalassaemia is the name of a group of genetic, inherited blood disorder passed down through families in which the body makes an abnormal form of… (more)

▼

Thalassaemia is the name of a group of genetic, inherited blood disorder passed down through families in which the body makes an abnormal form of hemoglobin. The disorder results in excessive destruction of red blood cells, which leads to anemia. It is not infectious and cannot be passed on from one individual to the other by personal or any other contact, or through blood transfusion, food or air. Thalassaemia is a major health problem, placing an immeasurable emotional, psychological and economic burden on millions of people around the world. Recent data indicate that about 7% of the world s population is a carrier of a hemoglobin disorder and that 300,000-500,000 children are born each year with the severe homozygous states of these diseases. There are two types of thalassemia, namely thalassemia major and thalassemia minor, when defective genes are inherited from either of the parents it is called as minor. When defective genes are inherited from both the parents, it is called thalassemia major. Transfusion is the mainstay of the care of individuals with thalassemia major. The purpose of transfusion is twofold; to improve the anemia and to suppress the ineffective erythropoiesis. Chronic transfusions prevent most of the serious growth, skeletal, and neurological complications of thalassemia major. However, once started, the transfusion-related complications become a major source of morbidity. Standards must be developed and maintained to ensure a safe and rational approach to the use of blood transfusions in the management of these rare disorders. Present work determined the frequency and the prevalence of the thalassemia of the study group, the geographical distribution, clinical findings and hematologic parameters analyses. The data were introduced into electronic system and were statistically analyzed. The current study aims to survey the effect of blood transfusion transmitted Malaria and other diseases in thalassemia patient from Solapur District (M.S.) India.

Bibliography p.123-146, Appendix p.147-171

Advisors/Committee Members: Nikam, Susheel V.

Subjects/Keywords: Blood Transfusion; Zoology; Malaria

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dama, S. B. (2012). Survey of blood transfusion-induced malaria and other diseases in thalassemia patients from Solapur District (M.S.) India; -. (Thesis). Dr. Babasaheb Ambedkar Marathwada University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dama, Swarupa Basavraj. “Survey of blood transfusion-induced malaria and other diseases in thalassemia patients from Solapur District (M.S.) India; -.” 2012. Thesis, Dr. Babasaheb Ambedkar Marathwada University. Accessed April 10, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/13688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dama, Swarupa Basavraj. “Survey of blood transfusion-induced malaria and other diseases in thalassemia patients from Solapur District (M.S.) India; -.” 2012. Web. 10 Apr 2021.

Vancouver:

Dama SB. Survey of blood transfusion-induced malaria and other diseases in thalassemia patients from Solapur District (M.S.) India; -. [Internet] [Thesis]. Dr. Babasaheb Ambedkar Marathwada University; 2012. [cited 2021 Apr 10]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dama SB. Survey of blood transfusion-induced malaria and other diseases in thalassemia patients from Solapur District (M.S.) India; -. [Thesis]. Dr. Babasaheb Ambedkar Marathwada University; 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

7. James, Vasanthie. The perceptions of health-care professionals regarding blood conservation in the private health sector.

Degree: 2011, University of Johannesburg

URL: http://hdl.handle.net/10210/4194

►

M.Cur.

Awareness of the growing list of potential and inherent risks and hazards associated with receiving donor blood has created a mushrooming interest in alternatives… (more)

Subjects/Keywords: Blood transfusion; Blood banks

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APA (6^th Edition):

James, V. (2011). The perceptions of health-care professionals regarding blood conservation in the private health sector. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/4194

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

James, Vasanthie. “The perceptions of health-care professionals regarding blood conservation in the private health sector.” 2011. Thesis, University of Johannesburg. Accessed April 10, 2021. http://hdl.handle.net/10210/4194.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

James, Vasanthie. “The perceptions of health-care professionals regarding blood conservation in the private health sector.” 2011. Web. 10 Apr 2021.

Vancouver:

James V. The perceptions of health-care professionals regarding blood conservation in the private health sector. [Internet] [Thesis]. University of Johannesburg; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10210/4194.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

James V. The perceptions of health-care professionals regarding blood conservation in the private health sector. [Thesis]. University of Johannesburg; 2011. Available from: http://hdl.handle.net/10210/4194

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Laval

8. Hendrick-Hallet, Julie. L'utilisation libérale des transfusions de plaquettes dans la réanimation initiale des patients polytraumatisés.

Degree: 2016, Université Laval

URL: http://hdl.handle.net/20.500.11794/27214

►

Cette revue systématique évalue l’effet d’une utilisation libérale de plaquettes (ratio élevé plaquettes:culots globulaires) en comparaison à une utilisation traditionnelle (faible ratio plaquettes:culots globulaires) dans… (more)

▼

Cette revue systématique évalue l’effet d’une utilisation libérale de plaquettes (ratio élevé plaquettes:culots globulaires) en comparaison à une utilisation traditionnelle (faible ratio plaquettes:culots globulaires) dans la réanimation initiale des polytraumatisés. Parmi 6123 références identifiées, nous avons sélectionné 7 études observationnelles comparatives incluant au total 4230 patients. Quatre études ont rapporté une diminution de la mortalité avec des ratios plaquettes:culots globulaires élevés chez des patients transfusés massivement. Une étude sur des patients sans hémorragie massive et une étude sur un nouveau protocole de transfusion massive n’ont rapporté aucune différence. L’hétérogénéité clinique et les failles méthodologiques des études n’ont pas permis d’effectuer une méta-analyse. Les données probantes actuelles sont insuffisantes pour appuyer l’utilisation d’un ratio plaquettes:culots globulaires spécifique dans la réanimation des polytraumatisés, surtout en considérant le biais de survie et les hémorragies non massives. Des essais cliniques randomisés évaluant la sécurité et l’efficacité d’un ratio élevé plaquettes:culots globulaires sont nécessaires avant de recommander leur utilisation.

This systematic review examines the impact of a liberal use of platelet transfusions (higher platelets:red blood cells ratio) compared to a traditional use (low platelets: red blood cells ratio) for the acute resuscitation of trauma patients. Seven observational comparative studies including 4230 patients were selected among 6123 titles identified. Four studies reported decreased mortality with higher PLT:RBC ratios among massively transfused patients. One study on non-massively transfused patients and one evaluating a new massive transfusion protocol did not report a survival benefit. Clinical heterogeneity and methodological flaws of the included studies precluded performing a meta-analysis. There is insufficient evidence to strongly support the liberal use of high PLT:RBC ratio for acute trauma resuscitation. Randomized controlled trials examining both the safety and efficacy of the liberal use of platelet transfusions with adjustment for other co-interventions are warranted before high PLT:RBC ratios can be broadly recommended.

Advisors/Committee Members: Lauzier, François, Turgeon-Fournier, Alexis.

Subjects/Keywords: Sang – Plaquettes – Transfusion; Blessés; Réanimation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hendrick-Hallet, J. (2016). L'utilisation libérale des transfusions de plaquettes dans la réanimation initiale des patients polytraumatisés. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/27214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hendrick-Hallet, Julie. “L'utilisation libérale des transfusions de plaquettes dans la réanimation initiale des patients polytraumatisés.” 2016. Thesis, Université Laval. Accessed April 10, 2021. http://hdl.handle.net/20.500.11794/27214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hendrick-Hallet, Julie. “L'utilisation libérale des transfusions de plaquettes dans la réanimation initiale des patients polytraumatisés.” 2016. Web. 10 Apr 2021.

Vancouver:

Hendrick-Hallet J. L'utilisation libérale des transfusions de plaquettes dans la réanimation initiale des patients polytraumatisés. [Internet] [Thesis]. Université Laval; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/20.500.11794/27214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hendrick-Hallet J. L'utilisation libérale des transfusions de plaquettes dans la réanimation initiale des patients polytraumatisés. [Thesis]. Université Laval; 2016. Available from: http://hdl.handle.net/20.500.11794/27214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Laval

9. Marcoux, Geneviève. Etude des mitochondries extracellulaires dans un contexte de transfusion plaquettaire.

Degree: 2015, Université Laval

URL: http://hdl.handle.net/20.500.11794/26188

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Les plaquettes, fragments de cellules, sont très abondantes dans le sang où elles favorisent l'hémostase. Activées, elles forment des microparticules (MPs) et libèrent des mitochondries… (more)

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Les plaquettes, fragments de cellules, sont très abondantes dans le sang où elles favorisent l'hémostase. Activées, elles forment des microparticules (MPs) et libèrent des mitochondries libres ou encapsulées. Comme la membrane mitochondriale est un substrat de la phospholipase A2 sécrétée qui libère des signaux inflammatoires, nos résultats permettent d'identifier les mitochondries extracellulaires au centre d'un mécanisme inflammatoire puissant qui fournit une explication possible de l'augmentation des niveaux sanguins d'ADNmt rapporté dans de multiples pathologies telles que les réactions transfusionnelles où l’ADNmt est présent à des niveaux plus élevés dans les PCs. Ici, nous avons étudié les MPs et les mitochondries extracellulaires dans différents types de PCs Les concentrations des MPs et des mitochondries extracellulaires étaient significativement plus élevées dans le PRP que les autres PC et sont stables dans l’entreposage. Le mode de préparation, plutôt que de la durée d’entreposage a un impact sur leur libération dans les PCs.

Platelets, anucleate cell fragments that contain mitochondria, are highly abundant in blood where they promote hemostasis. Activated platelets shed microparticles (MPs) and release respiratory-competent mitochondria, both within membrane-encapsulated microparticles and as free organelles. As the mitochondrion is an endogenous substrate of secreted phospholipase A2 IIA (sPLA2-IIA), which yields inflammatory mediators, our findings identify extracellular mitochondria at the midpoint of a potent mechanism leading to inflammatory responses. This mechanism provides a potential explanation for the increased levels of extracellular mtDNA reported in blood in multiple pathologies, such as adverse transfusion reactions where mtDNA is present at higher levels in PCs. Herein, we aimed to quantify MPs and extracellular mitochondria in different types of PCs through storage. Concentrations of MPs and extracellular mitochondria were significantly higher in PRP than other PCs and were stable over storage. The mode of preparation, rather than storage duration, impacts release of MPs and mitochondria in PCs.

Advisors/Committee Members: Boilard, Éric, Thibault, Louis.

Subjects/Keywords: Mitochondries; Sang – Plaquettes – Transfusion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marcoux, G. (2015). Etude des mitochondries extracellulaires dans un contexte de transfusion plaquettaire. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/26188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marcoux, Geneviève. “Etude des mitochondries extracellulaires dans un contexte de transfusion plaquettaire.” 2015. Thesis, Université Laval. Accessed April 10, 2021. http://hdl.handle.net/20.500.11794/26188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marcoux, Geneviève. “Etude des mitochondries extracellulaires dans un contexte de transfusion plaquettaire.” 2015. Web. 10 Apr 2021.

Vancouver:

Marcoux G. Etude des mitochondries extracellulaires dans un contexte de transfusion plaquettaire. [Internet] [Thesis]. Université Laval; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/20.500.11794/26188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marcoux G. Etude des mitochondries extracellulaires dans un contexte de transfusion plaquettaire. [Thesis]. Université Laval; 2015. Available from: http://hdl.handle.net/20.500.11794/26188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Isonishi, Ayami; Bennett, Charles L.; Plaimauer, Barbara; Scheiflinger, Friedrich; Matsumoto, Masanori. Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma. : 後天性血栓性血小板減少性紫斑病治療における血漿交換不応例は、ADAMTS13インヒピター力価の急上昇によって発生する : 治療中の患者血漿中ADAMTS13抗原抗体複合体の動態可視化.

Degree: 博士（医学）, 2017, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/3393

►

BACKGROUND: Plasma exchange (PE) is the first-line treatment for primary acquired thrombotic thrombocytopenic purpura (aTTP) with severe deficiency of ADAMTS13 activity (ADAMTS13:AC). Some patients are… (more)

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BACKGROUND: Plasma exchange (PE) is the first-line treatment for primary acquired thrombotic thrombocytopenic purpura (aTTP) with severe deficiency of ADAMTS13 activity (ADAMTS13:AC). Some patients are poor responders to PE, raising concern over multiple pathogenetic pathways. STUDY DESIGN AND METHODS: Based on 52 aTTP patients in our national cohort study, we monitored plasma levels of ADAMTS13, clinical and laboratory findings, and outcomes. In a representative poor responder to PE, we examined an ADAMTS13 inhibitor (ADAMTS13:INH) complex in plasma milieu, by means of a large-pore isoelectric focusing (IEF) analysis. RESULTS: Of 52 aTTP patients, 20 were good responders and 32 were poor responders. In the latter group, plasma ADAMTS13:AC levels never increased to more than 10% of normal during 14 days after PE initiation. Mean (±SD) plasma ADAMTS13:INH titers (Bethesda unit/mL) were 5.7 (±4.5) before PE, but decreased to 1.4 (±0.8) on the fourth PE day and then remarkably increased to 14.8 (±10.0) on the 10th PE day, termed "inhibitor boosting," and then slowly decreased to undetectable level over 1 month. On admission, none of the routinely available clinical and laboratory markers differentiated these two groups. However, elevated pre-PE levels of ADAMTS13:INH were correlated with a poor response. We visualized an ADAMTS13:INH (immunoglobulin G) complex in a patient plasma by an IEF analysis and found proteolytic fragment of ADAMTS13 antigen by a two-dimensional IEF and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis. CONCLUSION: Findings from this cohort of aTTP patients demonstrated that inhibitor boosting often occurs in aTTP patients in Japan. Poor responders could be predicted by elevated pre-PE ADAMTS13:INH levels on admission, but not by routinely collected clinical or laboratory data.

博士（医学）・乙第1412号・平成29年11月24日

Subjects/Keywords: FFP Transfusion; Immune Thrombocytopenia

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APA (6^th Edition):

Isonishi, Ayami; Bennett, Charles L.; Plaimauer, Barbara; Scheiflinger, Friedrich; Matsumoto, M. (2017). Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma. : 後天性血栓性血小板減少性紫斑病治療における血漿交換不応例は、ADAMTS13インヒピター力価の急上昇によって発生する : 治療中の患者血漿中ADAMTS13抗原抗体複合体の動態可視化. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/3393

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Isonishi, Ayami; Bennett, Charles L.; Plaimauer, Barbara; Scheiflinger, Friedrich; Matsumoto, Masanori. “Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma. : 後天性血栓性血小板減少性紫斑病治療における血漿交換不応例は、ADAMTS13インヒピター力価の急上昇によって発生する : 治療中の患者血漿中ADAMTS13抗原抗体複合体の動態可視化.” 2017. Thesis, Nara Medical University / 奈良県立医科大学. Accessed April 10, 2021. http://hdl.handle.net/10564/3393.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Isonishi, Ayami; Bennett, Charles L.; Plaimauer, Barbara; Scheiflinger, Friedrich; Matsumoto, Masanori. “Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma. : 後天性血栓性血小板減少性紫斑病治療における血漿交換不応例は、ADAMTS13インヒピター力価の急上昇によって発生する : 治療中の患者血漿中ADAMTS13抗原抗体複合体の動態可視化.” 2017. Web. 10 Apr 2021.

Vancouver:

Isonishi, Ayami; Bennett, Charles L.; Plaimauer, Barbara; Scheiflinger, Friedrich; Matsumoto M. Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma. : 後天性血栓性血小板減少性紫斑病治療における血漿交換不応例は、ADAMTS13インヒピター力価の急上昇によって発生する : 治療中の患者血漿中ADAMTS13抗原抗体複合体の動態可視化. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2017. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10564/3393.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Isonishi, Ayami; Bennett, Charles L.; Plaimauer, Barbara; Scheiflinger, Friedrich; Matsumoto M. Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma. : 後天性血栓性血小板減少性紫斑病治療における血漿交換不応例は、ADAMTS13インヒピター力価の急上昇によって発生する : 治療中の患者血漿中ADAMTS13抗原抗体複合体の動態可視化. [Thesis]. Nara Medical University / 奈良県立医科大学; 2017. Available from: http://hdl.handle.net/10564/3393

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Bennett, Sean. The Use of Perioperative Red Blood Cell Transfusions and Their Appropriateness in Liver Resection .

Degree: 2017, University of Ottawa

URL: http://hdl.handle.net/10393/36531

► Liver resection, or hepatectomy, is a major abdominal surgery performed most often for the removal of malignant tumors of the liver, either primary or metastatic.… (more)

Subjects/Keywords: liver resection; blood transfusion; appropriateness

8 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bennett, S. (2017). The Use of Perioperative Red Blood Cell Transfusions and Their Appropriateness in Liver Resection . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/36531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bennett, Sean. “The Use of Perioperative Red Blood Cell Transfusions and Their Appropriateness in Liver Resection .” 2017. Thesis, University of Ottawa. Accessed April 10, 2021. http://hdl.handle.net/10393/36531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bennett, Sean. “The Use of Perioperative Red Blood Cell Transfusions and Their Appropriateness in Liver Resection .” 2017. Web. 10 Apr 2021.

Vancouver:

Bennett S. The Use of Perioperative Red Blood Cell Transfusions and Their Appropriateness in Liver Resection . [Internet] [Thesis]. University of Ottawa; 2017. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10393/36531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bennett S. The Use of Perioperative Red Blood Cell Transfusions and Their Appropriateness in Liver Resection . [Thesis]. University of Ottawa; 2017. Available from: http://hdl.handle.net/10393/36531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Connecticut State University

12. Noorani, Shanila S., 1987-. Transfusion-Related Acute Lung Injury : History, Anesthetic Implications, Complications, and Management.

Degree: Department of Biological Sciences, 2013, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,1925

►

Approximately thirty million blood components are administered in the United States each year, most of which are given during the perioperative period. For years blood… (more)

▼

Approximately thirty million blood components are administered in the United States each year, most of which are given during the perioperative period. For years blood transfusions have been accepted as a standard of care in a variety of clinical scenarios, even with lacking evidence for improved outcomes. Despite a long history of blood transfusion, protocols still lack agreement on when to transfuse. Transfusion recommendations exist, but there still remains no universal accepted blood transfusion threshold. Blood transfusion carries with it numerous risks. However, with sophisticated infectious disease blood screening, the risk of infectious disease from blood transfusion has significantly decreased over the last decade. Non-infectious complications are now the leading complication of blood transfusions. The most common causes of transfusion related deaths are transfusion-related acute lung injury (TRALI), hemolytic transfusion reactions, and transfusion related sepsis. This thesis reviewed the literature that examined the pathophysiology of TRALI and its causes. TRALI is a non-cardiogenic pulmonary edema, characterized by respiratory distress, developing during or within six hours of a blood transfusion TRALI is usually associated with antibodies and biologically active lipids in the donor's blood. Clinical and laboratory researchers agree that the two pathophysiological mechanisms responsible for TRALI are antibody-mediated and antibody-independent. Mere transfusion of blood products does not cause TRALI but instead occurs in patients with activated neutrophils or activated pulmonary endothelium. Accumulation of neutrophils in the recipient's lungs occurs with release of neutrophil granule contents, resulting in injury to cellular membranes, endothelial surfaces, and potentially to lung parenchyma. Knowledge of the normal physiology of the alveolar-pulmonary capillary interface, comprehension of the pathophysiology of the disease process, screening for risk factors, making the appropriate diagnosis, followed by prompt treatment can lead to one less fatality due to blood transfusion. Anesthesia providers are responsible for a thorough preoperative review and patient assessment to identify risk factors for organ ischemia and coagulopathy. The risks and benefits of blood transfusion should be discussed with each patient. Intraoperative management includes close monitoring of vital signs, fluid and blood management, and monitoring for adverse reactions should a blood transfusion be given.

"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science in Biological Sciences: Anesthesia."; Thesis advisor: Ruth Rollin.; M.S.,Central Connecticut State University,,2013.;

Advisors/Committee Members: Rollin, Ruth.

Subjects/Keywords: Blood – Transfusion – Complications.; Anesthesia.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Noorani, Shanila S., 1. (2013). Transfusion-Related Acute Lung Injury : History, Anesthetic Implications, Complications, and Management. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,1925

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Noorani, Shanila S., 1987-. “Transfusion-Related Acute Lung Injury : History, Anesthetic Implications, Complications, and Management.” 2013. Thesis, Central Connecticut State University. Accessed April 10, 2021. http://content.library.ccsu.edu/u?/ccsutheses,1925.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Noorani, Shanila S., 1987-. “Transfusion-Related Acute Lung Injury : History, Anesthetic Implications, Complications, and Management.” 2013. Web. 10 Apr 2021.

Vancouver:

Noorani, Shanila S. 1. Transfusion-Related Acute Lung Injury : History, Anesthetic Implications, Complications, and Management. [Internet] [Thesis]. Central Connecticut State University; 2013. [cited 2021 Apr 10]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1925.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noorani, Shanila S. 1. Transfusion-Related Acute Lung Injury : History, Anesthetic Implications, Complications, and Management. [Thesis]. Central Connecticut State University; 2013. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1925

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Jansen, Gerard. Evidence Based Studies in Clinical Transfusion Medicine.

Degree: 2007, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/8262

► textabstractAfter the introduction of blood component therapy in the 1960s, more and more attention is given to clinical transfusion medicine. Although blood transfusion is an… (more)

Subjects/Keywords: blood transfusion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jansen, G. (2007). Evidence Based Studies in Clinical Transfusion Medicine. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/8262

Chicago Manual of Style (16^th Edition):

Jansen, Gerard. “Evidence Based Studies in Clinical Transfusion Medicine.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 10, 2021. http://hdl.handle.net/1765/8262.

MLA Handbook (7^th Edition):

Jansen, Gerard. “Evidence Based Studies in Clinical Transfusion Medicine.” 2007. Web. 10 Apr 2021.

Vancouver:

Jansen G. Evidence Based Studies in Clinical Transfusion Medicine. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1765/8262.

Council of Science Editors:

Jansen G. Evidence Based Studies in Clinical Transfusion Medicine. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/8262

University of Hong Kong

14. 骆融融. Motivators and deterrents for blood donation: a systematic review.

Degree: 2012, University of Hong Kong

URL: http://hdl.handle.net/10722/179921

► Blood donation is an important public health issue globally and locally. Recruitment and retention of blood donors are the biggest challenge for blood donation. The… (more)

Subjects/Keywords: Blood - Transfusion.

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APA (6^th Edition):

骆融融. (2012). Motivators and deterrents for blood donation: a systematic review. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/179921

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

骆融融. “Motivators and deterrents for blood donation: a systematic review.” 2012. Thesis, University of Hong Kong. Accessed April 10, 2021. http://hdl.handle.net/10722/179921.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

骆融融. “Motivators and deterrents for blood donation: a systematic review.” 2012. Web. 10 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

骆融融. Motivators and deterrents for blood donation: a systematic review. [Internet] [Thesis]. University of Hong Kong; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10722/179921.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

骆融融. Motivators and deterrents for blood donation: a systematic review. [Thesis]. University of Hong Kong; 2012. Available from: http://hdl.handle.net/10722/179921

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

15. 陳家樂. Evaluation of red cell transfusion practice in medical patients of a regional hospital in Hong Kong : a prospective study of transfusion practice and survey of clinicians.

Degree: 2016, University of Hong Kong

URL: http://hdl.handle.net/10722/237238

► Introduction: Blood products are precious resources and blood transfusion carries risks. Patient blood management is currently advocated to enhance clinical outcomes. Evolving evidence and guidelines… (more)

Subjects/Keywords: Erythrocytes - Transfusion

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APA (6^th Edition):

陳家樂. (2016). Evaluation of red cell transfusion practice in medical patients of a regional hospital in Hong Kong : a prospective study of transfusion practice and survey of clinicians. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/237238

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

陳家樂. “Evaluation of red cell transfusion practice in medical patients of a regional hospital in Hong Kong : a prospective study of transfusion practice and survey of clinicians.” 2016. Thesis, University of Hong Kong. Accessed April 10, 2021. http://hdl.handle.net/10722/237238.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

陳家樂. “Evaluation of red cell transfusion practice in medical patients of a regional hospital in Hong Kong : a prospective study of transfusion practice and survey of clinicians.” 2016. Web. 10 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

陳家樂. Evaluation of red cell transfusion practice in medical patients of a regional hospital in Hong Kong : a prospective study of transfusion practice and survey of clinicians. [Internet] [Thesis]. University of Hong Kong; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10722/237238.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

陳家樂. Evaluation of red cell transfusion practice in medical patients of a regional hospital in Hong Kong : a prospective study of transfusion practice and survey of clinicians. [Thesis]. University of Hong Kong; 2016. Available from: http://hdl.handle.net/10722/237238

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

16. Duong, Timothy Loi. The association between perioperative blood product transfusion and outcomes following orthotopic liver transplantation .

Degree: 2018, University of Sydney

URL: http://hdl.handle.net/2123/18662

► There is controversy regarding the effect of blood product transfusion on patients undergoing liver transplantation. De Boer et al. suggested an association between platelet transfusion… (more)

Subjects/Keywords: anaesthesia; liver transplantation; transfusion; blood

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APA (6^th Edition):

Duong, T. L. (2018). The association between perioperative blood product transfusion and outcomes following orthotopic liver transplantation . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/18662

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Duong, Timothy Loi. “The association between perioperative blood product transfusion and outcomes following orthotopic liver transplantation .” 2018. Thesis, University of Sydney. Accessed April 10, 2021. http://hdl.handle.net/2123/18662.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Duong, Timothy Loi. “The association between perioperative blood product transfusion and outcomes following orthotopic liver transplantation .” 2018. Web. 10 Apr 2021.

Vancouver:

Duong TL. The association between perioperative blood product transfusion and outcomes following orthotopic liver transplantation . [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2123/18662.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Duong TL. The association between perioperative blood product transfusion and outcomes following orthotopic liver transplantation . [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/18662

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Bealer, Michelle N. Preventing Blood Component Administration Errors.

Degree: MSN, 2016, University of San Francisco

URL: https://repository.usfca.edu/capstone/325

► By far the greatest risk to patients is human error; receiving the wrong blood component or one that is not compatible. A fatality subsequent… (more)

▼ By far the greatest risk to patients is human error; receiving the wrong blood component or one that is not compatible. A fatality subsequent to a blood transfusion is a devastation one cannot quantify. Blood transfusions are a routinely performed life saving intervention in the inpatient acute care hospital setting. Although blood transfusions can be extremely beneficial when delivered correctly, the risks associated with receiving incorrect blood components are severe and potentially fatal. The blood component administration process in the inpatient acute care hospital setting is dependent upon the systematic function of both communication and interaction technology. Therefore, the Institute for Healthcare Improvement’s Idealized Design of Clinical Practice (IDCOP) program (IDCOP), Interaction, provided the clinical framework for this project. A mixed closed, thirty-four bed critical care unit, was utilized for this project, which presented many opportunities to evaluate and trial the blood component administration process. Lewin’s change theory, unfreeze, move, and refreeze provided the methodology for this project. We determined, enhanced communication was needed and implemented a checklist to be dispensed along with the blood component to assist healthcare workers in completing all steps in the process. Real time audits were conducted of dispensing, administering, and monitoring of blood components after administration, yielding quantitative data for further analysis. Multiple PDSA’s were conducted each time the checklist was revised and implemented. A transfusion navigator was put into the electronic charting system to assist healthcare workers with the steps associated with blood component administration. To aid in sustainability a teach-back process to confirm competency was implemented for nurses to be initiated in the event of fallouts or errors improve knowledge retention and improve outcomes. The interventions put in place during this project were both effective and sustainable as the goal to reduce blood component administration errors by 50% by the end of the first quarter of 2016 was attained and the new process has been included in new policies.

Subjects/Keywords: Blood Component; Administration; Transfusion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bealer, M. N. (2016). Preventing Blood Component Administration Errors. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bealer, Michelle N. “Preventing Blood Component Administration Errors.” 2016. Thesis, University of San Francisco. Accessed April 10, 2021. https://repository.usfca.edu/capstone/325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bealer, Michelle N. “Preventing Blood Component Administration Errors.” 2016. Web. 10 Apr 2021.

Vancouver:

Bealer MN. Preventing Blood Component Administration Errors. [Internet] [Thesis]. University of San Francisco; 2016. [cited 2021 Apr 10]. Available from: https://repository.usfca.edu/capstone/325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bealer MN. Preventing Blood Component Administration Errors. [Thesis]. University of San Francisco; 2016. Available from: https://repository.usfca.edu/capstone/325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

18. Crawford, Tara Marie. The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial.

Degree: 2020, University of Adelaide

URL: http://hdl.handle.net/2440/129617

► Packed red blood cell (PRBC) transfusions continue to result in adverse inflammatory responses and increased rates of morbidity despite modifications in processing such as leukodepletion.… (more)

▼ Packed red blood cell (PRBC) transfusions continue to result in adverse inflammatory responses and increased rates of morbidity despite modifications in processing such as leukodepletion. It remains unknown if this is due to adverse physiological responses, inflammatory processes related to transfusion related immunomodulation (TRIM) or both. Washing of PRBCs may reduce the immunomodulatory potential and transfusion related adverse outcomes. This study aimed to investigate whether transfusion with washed leukodepleted PRBCs in the preterm newborn reduces post-transfusion inflammatory cytokine responses compared to transfusion with unwashed leukodepleted PRBCs, improving physiological stability. Extremely preterm newborns (n=154) were randomised to transfusion with unwashed or washed leukodepleted PRBCs, determined by the restrictive threshold of the PINT transfusion study, until primary hospital discharge (77 per arm). Plasma cytokines, markers of endothelial activation and measures of cardiorespiratory stability where measured pre- and post-transfusion. Transfusion with washed PRBCs resulted in decreases in pro-inflammatory cytokines while unwashed PRBCs resulted in increases in IL-17A and TNF. By the 3rd transfusion this response to unwashed PRBCs was associated with increases in MIF and PAI-1, markers of endothelial activation, an effect not seen with washed PRBCs. This response was influenced by donor sex with exposure to PRBCs from a female donor resulting in increases in pro-inflammatory cytokines, an effect ameliorated by PRBC washing. Changes over time and in response to the type of packed red blood cells transfused were seen with a greater reduction in cardiac output and increase in systemic vascular resistance and mean airway pressure seen in those infants transfused with washed PRBCs. However, none of these alterations met the current accepted definitions for either transfusion-associated circulatory overload or transfusion-associated lung injury. The current study suggests that the association between transfusion and poor outcome have a predominantly immunomodulatory basis, a relationship that may be altered by the use of washed packed red blood cells for the extremely preterm infant. The apparent lack of significant changes in cardio-respiratory responses to a transfusion may reflect the need for specific diagnostic criteria for transfusion related complication in the preterm newborn. The current results provide strong mechanistic data supporting a potentially beneficial effect of transfusion of washed packed red blood cells in this high-risk population. The next critical step is investigating whether the use of washed packed red blood cells is associated with a significant reduction in clinical outcomes, a finding which would have wide ranging implications for both transfusion medicine and the field of neonatology. Advisors/Committee Members: Robertson, Sarah (advisor), Andersen, Chad (advisor), Hodyl, Nicolette (advisor), School of Medicine (school).

Subjects/Keywords: Transfusion; Preterm Infant; Inflammation; Morbidity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Crawford, T. M. (2020). The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/129617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Crawford, Tara Marie. “The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial.” 2020. Thesis, University of Adelaide. Accessed April 10, 2021. http://hdl.handle.net/2440/129617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Crawford, Tara Marie. “The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial.” 2020. Web. 10 Apr 2021.

Vancouver:

Crawford TM. The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial. [Internet] [Thesis]. University of Adelaide; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2440/129617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Crawford TM. The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial. [Thesis]. University of Adelaide; 2020. Available from: http://hdl.handle.net/2440/129617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

19. Gleadall, Nicholas. Blood Donor Genotyping.

Degree: PhD, 2021, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/318843

► Transfusion of blood is one of the oldest and most widely used clinical interventions. In 2020 the World Health Organisation reported that globally 118.5 million… (more)

▼ Transfusion of blood is one of the oldest and most widely used clinical interventions. In 2020 the World Health Organisation reported that globally 118.5 million blood donations had been collected worldwide. This blood will be used to provide life-saving transfusion support for millions of individuals with a wide range of medical conditions. To ensure the safety of each blood transfusion it is common policy to identify and ensure compatibility between the ABO and RhD antigens of both donor and recipient. Although this policy prevents the majority of adverse haemolytic transfusion reaction’s (HTR), approximately 3% of recipients become sensitised following an immune reaction to a non-self blood group antigen after a single transfusion episode. This proportion can rise dramatically in patients requiring frequent transfusion support, with immunisation rates as high as 60% being reported for some haemoglobinopathy patients. Sensitisation to non-self red blood cell (RBC) antigens confers a lifetime risk of HTRs, which from 2013 through 2017 were responsible for 17% (32 of 185) and 6% (7 of 110) of transfusion-related deaths reported to the US Food and Drug Administration and Serious Hazards of Transfusion UK, respectively. Furthermore, sensitisation can render transfusion-dependent patients non-transfusable and cause haemolytic disease in pregnancy which is potentially life-threatening to the fetus. A more precise blood matching policy will reduce sensitisation rates, however, adoption of this is resisted because of perceived logistical challenges, donor typing costs, and the lack of evidence from large scale clinical trials that reducing sensitisation rates results in health gains. Antibody-based haemagglutination tests are the current gold standard for RBC antigen typing; however, reliable reagents and high-throughput techniques are not available for all clinically relevant antigens. DNA-based tests have been used to overcome these limitations, and a range of in-house and commercial assays have been developed for donor genotyping. However, due to the limited number of antigens typed for and the low throughput capacity of these assays, they have not been widely applied to blood donor typing. Advances in the technologies used for genome-wide genotyping and sequencing have substantially reduced the cost of generating genetic variation data at population scale. Multiple studies have demonstrated that it is possible to extract antigen typing information from the data produced by these technologies, indicating that they could be used to deliver genomics-based precision transfusion medicine to the patient bedside. However, the same studies also highlight a series of challenges that would have to be overcome before these technologies could be safely integrated into the clinical laboratory. In this thesis, I will present the work that has been done to overcome some of the issues surrounding the interpretation of blood cell antigen typing from genomic data and the development of a universal donor genotyping platform which can be…

Subjects/Keywords: Transfusion Medicine; Haematology; Genetics; Genomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gleadall, N. (2021). Blood Donor Genotyping. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/318843

Chicago Manual of Style (16^th Edition):

Gleadall, Nicholas. “Blood Donor Genotyping.” 2021. Doctoral Dissertation, University of Cambridge. Accessed April 10, 2021. https://www.repository.cam.ac.uk/handle/1810/318843.

MLA Handbook (7^th Edition):

Gleadall, Nicholas. “Blood Donor Genotyping.” 2021. Web. 10 Apr 2021.

Vancouver:

Gleadall N. Blood Donor Genotyping. [Internet] [Doctoral dissertation]. University of Cambridge; 2021. [cited 2021 Apr 10]. Available from: https://www.repository.cam.ac.uk/handle/1810/318843.

Council of Science Editors:

Gleadall N. Blood Donor Genotyping. [Doctoral Dissertation]. University of Cambridge; 2021. Available from: https://www.repository.cam.ac.uk/handle/1810/318843

20. Tariket, Sofiane. Investigation de la pathogenèse du syndrome de détresse respiratoire aiguë post-transfusionnel (TRALI) dans un modèle murin : Investigation of Transfusion-Related Acute Lung Injury (TRALI) pathogenesis in a mouse model.

Degree: Docteur es, Sciences de la vie et de la sante, 2017, Lyon

URL: http://www.theses.fr/2017LYSES059

►

La transfusion sanguine permet de sauver des vies et réduit la morbidité pour un grand nombre de maladies et d'affections cliniques, mais elle n'est pas… (more)

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La transfusion sanguine permet de sauver des vies et réduit la morbidité pour un grand nombre de maladies et d'affections cliniques, mais elle n'est pas exempte de complications. Un incident néfaste lié à une transfusion, également appelé Effet Indésirable Receveur (EIR), est un incident défavorable survenant chez un patient pendant ou après une transfusion sanguine. Parmi eux, le TRALI est considéré comme l’une des réactions inflammatoires les plus critiques. Cette pathologie se développe généralement dans les 6 heures après transfusion. On en reconnaît deux types, les TRALI immunologiques et les TRALI non-immunologiques. En France, les premiers sont presque entièrement prévenus par une politique de sécurité des produits sanguins, tandis que la fréquence des seconds augmente. La physiopathologie du TRALI reste mal connue. Tandis que certains y accordent une place importante aux plaquettes sanguines du patient transfusé, d’autres les considèrent comme pas réellement impliquées. Le but de ce travail de thèse a été, dans un premier temps, d’investiguer le potentiel inflammatoire des plaquettes sanguines conservées dans les concentrés plaquettaires et l’influence de cette inflammation sur l’endothélium vasculaire général. Ensuite, sera évalué le rôle des plaquettes sanguines de l’organisme, notamment par l’intermédiaire de leurs produits de sécrétion, dans la pathogénie de cette complication transfusionnelle. Pour cela, un ALI (mimant un TRALI) a été déclenché, dans un modèle in vivo, par une injection d’anticorps anti-CMH I chez des souris préalablement stimulées avec du LPS. L’ensemble de nos résultats confirme le potentiel inflammatoire des plaquettes sanguines, au sein des concentrés plaquettaires, pouvant probablement assumer l’entière responsabilité du déclenchement d’un TRALI non-immunologique, ainsi qu’un rôle secondaire des plaquettes sanguines de l’organisme, participant activement à l’amplification de la sévérité de la pathologie. Cette thèse s’inscrit dans la continuité logique des études menées, au sein du laboratoire GIMAP-EA3064, investiguant la place des plaquettes sanguines au sein de l’inflammation, ouvrant ainsi de nouvelles perspectives dans la sécurité transfusionnelle.

Blood transfusion saves lives and reduces morbidity for many diseases and clinical conditions, but it is not without complications. A transfusion-related adverse event, also known as the Adverse Reaction (AR), is an incident occurring in a patient during or after a blood transfusion. Among them, TRALI is considered as one of the most critical inflammatory reactions. This pathology usually occurs within 6 hours after transfusion. Two types are recognized: immune TRALI and non-immune TRALI. In France, the first is almost completely prevented by a blood product safety policy, while the frequency of the second increases. The pathophysiology of TRALI remains poorly understood. While some scientists give an important function of patient blood platelets, others consider them dispensable. The aim of this thesis was, first, to investigate…

Advisors/Committee Members: Cognasse, Fabrice (thesis director), Garraud, Olivier (thesis director).

Subjects/Keywords: TRALI; Transfusion; Plaquettes; Inflammation; CD40L; TRALI; Transfusion; Platelets; Inflammation; CD40L

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tariket, S. (2017). Investigation de la pathogenèse du syndrome de détresse respiratoire aiguë post-transfusionnel (TRALI) dans un modèle murin : Investigation of Transfusion-Related Acute Lung Injury (TRALI) pathogenesis in a mouse model. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2017LYSES059

Chicago Manual of Style (16^th Edition):

Tariket, Sofiane. “Investigation de la pathogenèse du syndrome de détresse respiratoire aiguë post-transfusionnel (TRALI) dans un modèle murin : Investigation of Transfusion-Related Acute Lung Injury (TRALI) pathogenesis in a mouse model.” 2017. Doctoral Dissertation, Lyon. Accessed April 10, 2021. http://www.theses.fr/2017LYSES059.

MLA Handbook (7^th Edition):

Tariket, Sofiane. “Investigation de la pathogenèse du syndrome de détresse respiratoire aiguë post-transfusionnel (TRALI) dans un modèle murin : Investigation of Transfusion-Related Acute Lung Injury (TRALI) pathogenesis in a mouse model.” 2017. Web. 10 Apr 2021.

Vancouver:

Tariket S. Investigation de la pathogenèse du syndrome de détresse respiratoire aiguë post-transfusionnel (TRALI) dans un modèle murin : Investigation of Transfusion-Related Acute Lung Injury (TRALI) pathogenesis in a mouse model. [Internet] [Doctoral dissertation]. Lyon; 2017. [cited 2021 Apr 10]. Available from: http://www.theses.fr/2017LYSES059.

Council of Science Editors:

Tariket S. Investigation de la pathogenèse du syndrome de détresse respiratoire aiguë post-transfusionnel (TRALI) dans un modèle murin : Investigation of Transfusion-Related Acute Lung Injury (TRALI) pathogenesis in a mouse model. [Doctoral Dissertation]. Lyon; 2017. Available from: http://www.theses.fr/2017LYSES059

21. Elayeb, Rahma. Étude des mécanismes de l'allo-immunisation post-transfusionnelle : Cellular mechanisms of post-transfusionnal alloimmunization.

Degree: Docteur es, Biologie cellulaire et moléculaire, 2016, Université Paris-Est

URL: http://www.theses.fr/2016PESC0076

►

La transfusion sanguine est un traitement essentiel à la survie de millions de patients. Son principal risque immunologique est l’allo-immunisation post-transfusionnelle. Elle se traduit par… (more)

▼

La transfusion sanguine est un traitement essentiel à la survie de millions de patients. Son principal risque immunologique est l’allo-immunisation post-transfusionnelle. Elle se traduit par la production d’allo-anticorps contre des antigènes de globules rouges (GR) conduisant à des hémolyses post-transfusionnelles. Les mécanismes à l’origine de la tolérance des GR ou de son inhibition lors de l’allo-immunisation sont mal connus. Ainsi, mes travaux de thèse, portant sur la compréhension de ces effets, se sont articulés en trois parties avec 1/ l’étude des conditions optimales aux réponses allo-immunes, 2/ l’étude des effets d’une stratégie thérapeutique utilisant un anticorps monoclonal et 3/ l’étude des effets immunomodulateurs, incluant la tolérance, médiée par des composants présents dans les concentrés de globules rouges (CGR).Afin d’étudier l’allo-immunisation, nous avons utilisé le modèle murin. Nous montrons qu’une variation du délai entre la transfusion et la stimulation du TLR3 impacte la réponse immune dans la rate. Une activation importante des lymphocytes T CD4+ (LT CD4+) allo-réactifs accompagnée d’une production accrue d’allo-anticorps ont été montrées à 7 jours de délai. Afin de limiter l’allo-immunisation, l’utilisation d’un anticorps anti-CD20 déplétant les lymphocytes B (LB) montre une altération des LB mais surtout des LT CD4+ impliqués dans le processus d’induction de l’allo-immunisation. Enfin, la modification du phénotype des cellules dendritiques CD11c+ de la rate des souris transfusées, observée hors contexte inflammatoire, suggère une maturation incomplète à l’origine d’une tolérance antigénique. Pour finir, l’analyse de différents composants présents dans les CGR confirme l’existence de microparticules (MPs) lymphocytaires. Ces MPs présentent des molécules inhibitrices et pourraient donc être impliquées dans la tolérance des antigènes transfusés.En conclusion, mes travaux montrent la coopération des DCs avec les LT CD4+ permettant celle des LT CD4+ avec les LB pour induire une réponse immune. Comme toute réponse humorale, nous confirmons que l’allo-immunisation fait intervenir des DCs, des LT CD4+ et des LB. Ces résultats ouvrent de nouvelles voies de recherche pour mieux caractériser l’allo-immunisation en particulier chez les patients drépanocytaires qui sont les plus touchés.

Red blood cell (RBC) transfusion is a life-saving treatment for millions of patients. However, its main immunological risk is RBC alloimmunization resulting in antibody production against RBC antigen. Alloimmunization can lead to severe complications threatening the life of the patient. The mechanisms explaining RBC alloimmunization are poorly understood. Therefore, my doctoral work aiming at understanding transfusion effects, was subdivided into three parts with 1/ the study of optimal conditions for alloimmune responses, 2/ the impact of a therapeutic strategy using a monoclonal antibody to inhibit alloimmunization and 3/ the study of immunomodulatory effects of transfusion, including tolerance, through…

Advisors/Committee Members: Noizat-Pirenne, France (thesis director).

Subjects/Keywords: Allo-Immunisation; Transfusion; Réponses immunes; Alloimmunization; Transfusion; Immune responses; 610

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Elayeb, R. (2016). Étude des mécanismes de l'allo-immunisation post-transfusionnelle : Cellular mechanisms of post-transfusionnal alloimmunization. (Doctoral Dissertation). Université Paris-Est. Retrieved from http://www.theses.fr/2016PESC0076

Chicago Manual of Style (16^th Edition):

Elayeb, Rahma. “Étude des mécanismes de l'allo-immunisation post-transfusionnelle : Cellular mechanisms of post-transfusionnal alloimmunization.” 2016. Doctoral Dissertation, Université Paris-Est. Accessed April 10, 2021. http://www.theses.fr/2016PESC0076.

MLA Handbook (7^th Edition):

Elayeb, Rahma. “Étude des mécanismes de l'allo-immunisation post-transfusionnelle : Cellular mechanisms of post-transfusionnal alloimmunization.” 2016. Web. 10 Apr 2021.

Vancouver:

Elayeb R. Étude des mécanismes de l'allo-immunisation post-transfusionnelle : Cellular mechanisms of post-transfusionnal alloimmunization. [Internet] [Doctoral dissertation]. Université Paris-Est; 2016. [cited 2021 Apr 10]. Available from: http://www.theses.fr/2016PESC0076.

Council of Science Editors:

Elayeb R. Étude des mécanismes de l'allo-immunisation post-transfusionnelle : Cellular mechanisms of post-transfusionnal alloimmunization. [Doctoral Dissertation]. Université Paris-Est; 2016. Available from: http://www.theses.fr/2016PESC0076

22. Ternström, Lisa. Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery.

Degree: 2015, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/38005

► Abstract Excessive bleeding after cardiac surgery is a serious complication that is associated with increased morbidity and mortality. The bleeding is multifactorial and influenced by… (more)

▼ Abstract Excessive bleeding after cardiac surgery is a serious complication that is associated with increased morbidity and mortality. The bleeding is multifactorial and influenced by both surgical factors and impaired haemostasis. It is important to identify patients with increased risk of bleeding before the operation so countermeasures can be initiated. A large proportion of cardiac surgical patients receive blood transfusions during and after surgery. Transfusion therapy can save lives, but is also associated with increased risk of morbidity and mortality, so unnecessary transfusions should be avoided. There is little knowledge about when and on what indication blood transfusions are administered, and how well treating physicians follow current guidelines. Aims: One aim was to examine the relationship between preoperative levels of fibrinogen and other coagulation factors, and their relationship to postoperative bleeding and blood transfusion. Another was to assess the effects of a structured blood conservation programme, with the objective of reducing the administration of blood transfusions in cardiac surgical patients. A third aim was to study the prevalence, volumes and indications for red blood cell transfusions in cardiac surgery patients. The final aim was to examine adherence to institutional transfusion guidelines. Materials and methods: The first study (Paper I) involved 170 patients undergoing coronary artery bypass grafting (CABG). Data on each patient´s preoperative fibrinogen plasma concentration and other haemostatic tests, and postoperative bleeding and transfusion requirements, were collected. In Paper II, the study concerned 57 CABG patients. Plasma activity of coagulation factors involved in plasma coagulation was measured before and after surgery and related to haemodilution and postoperative blood loss. In Paper III, the study involved all 2162 patients who underwent cardiac surgery at our institution during a 24-month period. Transfusion requirements and transfusion-associated costs before and after introduction of a blood conservation programme were compared. In the study described in Paper IV, timing and indications for red blood cell transfusion in 1034 cardiac surgery patients were investigated and the adherence to institutional guidelines was assessed. Results: Paper I demonstrated that preoperative plasma levels of fibrinogen correlates significantly to postoperative blood loss. Preoperative fibrinogen level was also an independent predictor of red blood cell transfusion, together with female gender and long operation time. Paper II demonstrated a marked disparity of clotting factor activity after cardiac surgery. Only plasma concentration of fibrinogen and coagulation factor XIII activity correlated to postoperative bleeding. Paper III showed that the introduction of a simple structured multifactorial blood conservation programme significantly reduces blood transfusions to cardiac surgery patients, and reduces transfusion-associated costs without compromising medical safety. The…

Subjects/Keywords: cardiac surgery; bleeding; fibrinogen; blood transfusion; transfusion guidelines; adherence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ternström, L. (2015). Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/38005

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ternström, Lisa. “Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery.” 2015. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed April 10, 2021. http://hdl.handle.net/2077/38005.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ternström, Lisa. “Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery.” 2015. Web. 10 Apr 2021.

Vancouver:

Ternström L. Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2077/38005.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ternström L. Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. Available from: http://hdl.handle.net/2077/38005

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Sosnoski, Monalisa. Lesão de estoque de concentrado de hemácias e a relação com as reações transfusionais febris não hemolíticas.

Degree: 2017, Brazil

URL: http://hdl.handle.net/10183/172524

►

Introdução: As transfusões de sangue e as Reações transfusionais (RT) têm tido grande destaque nas discussões e estudos da hemoterapia atual, devido a necessidade e… (more)

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Introdução: As transfusões de sangue e as Reações transfusionais (RT) têm tido grande destaque nas discussões e estudos da hemoterapia atual, devido a necessidade e relevância para a prática transfusional e na busca em qualificar as transfusões e refinar a classificação das RT. As reações transfusionais febris não hemolíticas (RTFNH) apresentam um crescente no número de notificações e despertam a necessidade de mais estudos. Durante a estocagem dos hemocomponentes, ocorrem uma série de alterações morfológicas, aumento de potássio (K+) extracelular, hemólise e aumento de hemoglobina (Hb) sobrenadante. Analisar a qualidade e viabilidade do hemocomponente pode nos levar a verificar os fatores preditores de uma RT, procurando minimizar os riscos e selecionar um hemocomponente de melhor qualidade ao paciente. Objetivos: Avaliar potenciais fatores etiológicos na precipitação das RTFNH por meio da mensuração na concentração de sódio (Na+) e K+ no sobrenadante, a contagem leucocitária por mcL, o cultural e o Hematócrito (Ht) e Hb da bolsa de concentrado de hemácias (CH) envolvidas, comparando estes parâmetros em relação a um grupo controle de bolsas de CH. Analisar e comparar o perfil dos pacientes envolvidos com a RTFNH e do grupo controle e, estimar a frequência de culturais coletados positivos e os germes envolvidos. Metodologia: Estudo de caso-controle com seleção de amostras a partir de notificações de suspeita de RTFNH ao Serviço de Hemoterapia de um Hospital Universitário de Porto Alegre - RS, no período de setembro de 2015 a setembro de 2016. O grupo controle foi selecionado a partir da mesma população de bolsas, sendo pareadas por tipagem sanguínea e data de vencimento do hemocomponente, numa proporção de 1:2,1. Resultados: o total incluído foi de 124 bolsas, sendo 39(30,5%) do grupo RT e 85(69,5%) do grupo controle, onde uma série de variáveis foram avaliadas. A média de dias de estocagem das bolsas foi de 10,7(DP=6,7) dias, sendo que no grupo RT 12,1(DP=8,1), foi significativamente maior que no grupo controle 10(DP=5,8) com (P=0,037). Também quando avaliamos as dosagens de Ht as médias verificadas foram de 68,3(DP=7,27), sendo no grupo RT 71(DP=81) e 67(DP=6,5) no grupo controle e, na comparação dos grupos, observamos um P<0,001. Dessa forma, a cada dia a mais de estocagem e, a cada ponto a mais no HT da bolsa, há um aumento na chance de aparecimento de RTFNH. Conclusões: a lesão de estocagem é uma temática importante no momento da oferta de hemocomponentes ao paciente, principalmente aos pacientes em tratamento oncológico de tumores sólidos. A avaliação do HT e do tempo de estocagem da bolsa demonstraram ter relevância estatística e clínica na predição de aparecimento de RTFNH. O manejo de estoque adequado para poder haver essa oferta se faz necessário. Novos estudos serão necessários para verificarmos os mecanismos desencadeantes da RTFNH comparado com o Ht da bolsa e, também estudos relacionados à utilização de pré medicação nas transfusões.

Introduction: Blood transfusions and the transfusion reactions…

Advisors/Committee Members: Faulhaber, Gustavo Adolpho Moreira.

Subjects/Keywords: Transfusão de sangue; Reação transfusional; Eritrócitos; Blood transfusion; Red blood cell; Storage lesion; Non-hemolytic febrile transfusion reaction; Transfusion reaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sosnoski, M. (2017). Lesão de estoque de concentrado de hemácias e a relação com as reações transfusionais febris não hemolíticas. (Masters Thesis). Brazil. Retrieved from http://hdl.handle.net/10183/172524

Chicago Manual of Style (16^th Edition):

Sosnoski, Monalisa. “Lesão de estoque de concentrado de hemácias e a relação com as reações transfusionais febris não hemolíticas.” 2017. Masters Thesis, Brazil. Accessed April 10, 2021. http://hdl.handle.net/10183/172524.

MLA Handbook (7^th Edition):

Sosnoski, Monalisa. “Lesão de estoque de concentrado de hemácias e a relação com as reações transfusionais febris não hemolíticas.” 2017. Web. 10 Apr 2021.

Vancouver:

Sosnoski M. Lesão de estoque de concentrado de hemácias e a relação com as reações transfusionais febris não hemolíticas. [Internet] [Masters thesis]. Brazil; 2017. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10183/172524.

Council of Science Editors:

Sosnoski M. Lesão de estoque de concentrado de hemácias e a relação com as reações transfusionais febris não hemolíticas. [Masters Thesis]. Brazil; 2017. Available from: http://hdl.handle.net/10183/172524

University of Pretoria

24. Zambelli, A.B. (Anthony Brett). A comparison of the effects of packed red blood cell transfusion and Oxyglobin® in canine babesiosis .

Degree: 2008, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-07282008-103520/

► Blood transfusion forms a mainstay of the treatment of a variety of illnesses, and is lifesaving. Nonetheless, it is not without its risks and drawbacks.… (more)

Subjects/Keywords: Falciparum malarial anaemia; Oxyglobin®; Blood transfusion; UCTD

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APA (6^th Edition):

Zambelli, A. B. (. B. (2008). A comparison of the effects of packed red blood cell transfusion and Oxyglobin® in canine babesiosis . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-07282008-103520/

Chicago Manual of Style (16^th Edition):

Zambelli, A B (Anthony Brett). “A comparison of the effects of packed red blood cell transfusion and Oxyglobin® in canine babesiosis .” 2008. Masters Thesis, University of Pretoria. Accessed April 10, 2021. http://upetd.up.ac.za/thesis/available/etd-07282008-103520/.

MLA Handbook (7^th Edition):

Zambelli, A B (Anthony Brett). “A comparison of the effects of packed red blood cell transfusion and Oxyglobin® in canine babesiosis .” 2008. Web. 10 Apr 2021.

Vancouver:

Zambelli AB(B. A comparison of the effects of packed red blood cell transfusion and Oxyglobin® in canine babesiosis . [Internet] [Masters thesis]. University of Pretoria; 2008. [cited 2021 Apr 10]. Available from: http://upetd.up.ac.za/thesis/available/etd-07282008-103520/.

Council of Science Editors:

Zambelli AB(B. A comparison of the effects of packed red blood cell transfusion and Oxyglobin® in canine babesiosis . [Masters Thesis]. University of Pretoria; 2008. Available from: http://upetd.up.ac.za/thesis/available/etd-07282008-103520/

Cape Peninsula University of Technology

25. Peters, Yvonne Grace. A clinical audit of the utilisation of red blood cell products in elective total hip replacement surgery .

Degree: 2015, Cape Peninsula University of Technology

URL: http://etd.cput.ac.za/handle/20.500.11838/2239

► Previous international studies have documented a marked variation in transfusion practice for Total Hip Replacement (THR) surgery. This is despite widespread dissemination of clinical guidelines… (more)

Subjects/Keywords: Total hip replacement; Blood – Transfusion; Erythrocytes

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APA (6^th Edition):

Peters, Y. G. (2015). A clinical audit of the utilisation of red blood cell products in elective total hip replacement surgery . (Thesis). Cape Peninsula University of Technology. Retrieved from http://etd.cput.ac.za/handle/20.500.11838/2239

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peters, Yvonne Grace. “A clinical audit of the utilisation of red blood cell products in elective total hip replacement surgery .” 2015. Thesis, Cape Peninsula University of Technology. Accessed April 10, 2021. http://etd.cput.ac.za/handle/20.500.11838/2239.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peters, Yvonne Grace. “A clinical audit of the utilisation of red blood cell products in elective total hip replacement surgery .” 2015. Web. 10 Apr 2021.

Vancouver:

Peters YG. A clinical audit of the utilisation of red blood cell products in elective total hip replacement surgery . [Internet] [Thesis]. Cape Peninsula University of Technology; 2015. [cited 2021 Apr 10]. Available from: http://etd.cput.ac.za/handle/20.500.11838/2239.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peters YG. A clinical audit of the utilisation of red blood cell products in elective total hip replacement surgery . [Thesis]. Cape Peninsula University of Technology; 2015. Available from: http://etd.cput.ac.za/handle/20.500.11838/2239

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

26. Acacira Oliveira Bezerra de Araujo. Uso de concentrado de hemacias em neonatologia : o panorama brasileiro.

Degree: Faculdade de Ciências Médicas, 2007, Universidade Estadual de Campinas

URL: http://libdigi.unicamp.br/document/?code=vtls000415344

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The transfusion of Red Blood Cells (RBC) is often one of the therapeutical tools in advanced support in newborn intensive care units (NICU); the number… (more)

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The transfusion of Red Blood Cells (RBC) is often one of the therapeutical tools in advanced support in newborn intensive care units (NICU); the number of transfusions required depends on factors such as pregnancy duration and weight at birth. However, great variations are observed when comparing children in similar clinical conditions in different centers, as there are no controlled studies with established indications for newborn transfusion. Thus, the goal of the present study is to compare and describe the use of RBC transfusion through the qualitative and quantitative analysis of questionnaires in 42 services of NICUs in Brazil, focusing on its indications, repercussions and techniques; evaluating the presence and the adequacy of the protocols established from a scientific, descriptive, observational and longitudinal study. From this analysis, a more uniform protocol for the transfusion of RBC in Brazilian newborns is suggested. From the 42 hospital units studied, 20 are university hospitals, of which 17 are public institutions and 03 are private institutions. With respect to the service type, 26 units belong to SUS, 09 have private or insurance service and 07 work with both services (public and private). Furthermore, the institutions represent 4 regions of the country: 11 in the Northeast, 21 in the Southeast, 03 in Center-west and 07 in the South of Brazil; representing 670 NICU beds and 450 intermediate unit beds. The data collected was submitted to statistical analysis calculating the absolute and cumulative frequencies as well as the relative frequencies of each question of the applied questionnaires. No significant differences with respect to the use, preparation and indications were found when we analyzed private and educational institutions. However, the North and Northeast regions and the institutions geographically distant from the capitals, public services unrelated to universities have difficulty to access the hospital information, implementation and use of specific technologies. In the majority of the services, there is no interaction between the blood transfusion services and the NICUs; resulting in a difficult task for the professionals providing direct assistance. There are a large number of services that consider clinical parameters associated to the hemoglobin level (Hb) while others consider parameters associated to hematocrit (Hct) levels as a reference for the indication of transfusion of RBC. In conclusion, the decision of performing a transfusion in a patient must always be made by the leading doctor taking technical, medical, ethical and legal parameters into account, based on the use of protocols with more precise transfusion indications, adapted to the resources of each institution, in order to protect the patients from the risk of badly indicated transfusions

A transfusão de concentrado de hemácias (CH) é parte freqüente do arsenal terapêutico de suporte avançado nas unidades de terapia intensiva neonatal (UTINeo); o número de transfusões utilizadas depende de fatores como idade…

Advisors/Committee Members: Marcelo Addas de Carvalho [Orientador], Marcelo Addas de Carvalho, Antonio Fabron Junior, Abimael Aranha Neto, Maria de Lourdes R. B. de Castro.

Subjects/Keywords: Neonatologia; Blood transfusion; Hemoterapia; Sangue - Transfusão; Hemotherapy

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APA (6^th Edition):

Araujo, A. O. B. d. (2007). Uso de concentrado de hemacias em neonatologia : o panorama brasileiro. (Thesis). Universidade Estadual de Campinas. Retrieved from http://libdigi.unicamp.br/document/?code=vtls000415344

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Araujo, Acacira Oliveira Bezerra de. “Uso de concentrado de hemacias em neonatologia : o panorama brasileiro.” 2007. Thesis, Universidade Estadual de Campinas. Accessed April 10, 2021. http://libdigi.unicamp.br/document/?code=vtls000415344.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Araujo, Acacira Oliveira Bezerra de. “Uso de concentrado de hemacias em neonatologia : o panorama brasileiro.” 2007. Web. 10 Apr 2021.

Vancouver:

Araujo AOBd. Uso de concentrado de hemacias em neonatologia : o panorama brasileiro. [Internet] [Thesis]. Universidade Estadual de Campinas; 2007. [cited 2021 Apr 10]. Available from: http://libdigi.unicamp.br/document/?code=vtls000415344.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Araujo AOBd. Uso de concentrado de hemacias em neonatologia : o panorama brasileiro. [Thesis]. Universidade Estadual de Campinas; 2007. Available from: http://libdigi.unicamp.br/document/?code=vtls000415344

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

27. Barty, Rebecca. IS O REALLY THE UNIVERSAL DONOR?.

Degree: MSc, 2015, McMaster University

URL: http://hdl.handle.net/11375/18468

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An association between compatible but ABO non-identical red blood cell (RBC) transfusions and increased in-hospital mortality was identified in an observational study. A review of… (more)

Subjects/Keywords: Design thesis; O Red Blood Cells; Transfusion

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APA (6^th Edition):

Barty, R. (2015). IS O REALLY THE UNIVERSAL DONOR?. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18468

Chicago Manual of Style (16^th Edition):

Barty, Rebecca. “IS O REALLY THE UNIVERSAL DONOR?.” 2015. Masters Thesis, McMaster University. Accessed April 10, 2021. http://hdl.handle.net/11375/18468.

MLA Handbook (7^th Edition):

Barty, Rebecca. “IS O REALLY THE UNIVERSAL DONOR?.” 2015. Web. 10 Apr 2021.

Vancouver:

Barty R. IS O REALLY THE UNIVERSAL DONOR?. [Internet] [Masters thesis]. McMaster University; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11375/18468.

Council of Science Editors:

Barty R. IS O REALLY THE UNIVERSAL DONOR?. [Masters Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/18468

Texas A&M University

28. Daviano, Alexjandro Cristobal. Variables Associated with the Receipt of Blood Transfusions Among Critical Pediatric Trauma Patients at a Single Level 1 Trauma Center, Houston, Texas - 2011 to 2016.

Degree: Doctor of Public Health, Epidemiology and Environmental Health, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/173936

► Massive blood loss due to trauma requires faster recognition and treatment using established protocols to prevent death. Currently, adult guidelines are used for pediatric patients.… (more)

▼ Massive blood loss due to trauma requires faster recognition and treatment using established protocols to prevent death. Currently, adult guidelines are used for pediatric patients. This is not an optimal approach due to differences in blood volume, physiology, and body weight between adults and children. The lack of consistency in the indicators used in hospital massive transfusion protocols must be addressed in order to improve treatment for critically injured pediatric trauma patients. Cases of critical pediatric trauma patients (17 years and younger) from 2011 to 2016 were retrospectively analyzed from Memorial Hermann Texas Medical Center. Patients given blood products within 24 hours of injury were evaluated. Descriptive profiles were constructed through bivariate and means analysis that generated descriptive statistics for patient population explanation. Spearman correlations, Mann-Whitney tests, and Kruskal-Wallis tests were conducted to determine associations between demographic and clinical indicators and patient mean arterial pressures. Of the 397 cases, critical pediatric trauma patients who received blood products in the prehospital or in-hospital environment were more likely to have been intubated (odds ratio = 1.61; 95% confidence interval: 1.04, 2.51); more likely to have lower mean arterial pressures (mean arterial pressure ≤ 59: odds ratio = 4.04; 95% confidence interval: 1.95, 8.37); more likely to have lower systolic blood pressures (systolic blood pressure ≤ 89: odds ratio = 3.69; 95% confidence interval: 2.02, 6.76); and more likely to have lower heart rates (heart rate ≤ 59: odds ratio = 5.12; 95% confidence interval: 1.67, 15.70) compared to patients not given blood products. Critical pediatric trauma patients who received prehospital blood products came directly from emergency scenes, were preteenagers, were more frequently intubated, and had lower heights, weights, mean arterial pressures, systolic blood pressures, and heart rates than critical pediatric trauma patients who received blood products in-hospital. Critical pediatric trauma patient mean arterial pressures showed a moderate overall correlation with age, weight, and height. Profiled critical pediatric trauma patients show that mean arterial pressure, intubation, heart rate, height, weight, systolic blood pressure, and lack of severe head injury are associated with blood transfusion and prehospital blood transfusion. More research is needed to determine more appropriate factors associated with critical pediatric trauma patient massive transfusion protocol and prehospital treatment. Advisors/Committee Members: Horney, Jennifer (advisor), Shipp, Eva M (committee member), Taylor, Brandie (committee member), Zoh, Roger (committee member).

Subjects/Keywords: pediatric; emergency medicine; MAP; blood transfusion; blood loss; children; kids; prehospital; pre-hospital; transfusion; massive transfusion; MT; BT; protocols; MTP; massive transfusion protocols.

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APA (6^th Edition):

Daviano, A. C. (2018). Variables Associated with the Receipt of Blood Transfusions Among Critical Pediatric Trauma Patients at a Single Level 1 Trauma Center, Houston, Texas - 2011 to 2016. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173936

Chicago Manual of Style (16^th Edition):

Daviano, Alexjandro Cristobal. “Variables Associated with the Receipt of Blood Transfusions Among Critical Pediatric Trauma Patients at a Single Level 1 Trauma Center, Houston, Texas - 2011 to 2016.” 2018. Doctoral Dissertation, Texas A&M University. Accessed April 10, 2021. http://hdl.handle.net/1969.1/173936.

MLA Handbook (7^th Edition):

Daviano, Alexjandro Cristobal. “Variables Associated with the Receipt of Blood Transfusions Among Critical Pediatric Trauma Patients at a Single Level 1 Trauma Center, Houston, Texas - 2011 to 2016.” 2018. Web. 10 Apr 2021.

Vancouver:

Daviano AC. Variables Associated with the Receipt of Blood Transfusions Among Critical Pediatric Trauma Patients at a Single Level 1 Trauma Center, Houston, Texas - 2011 to 2016. [Internet] [Doctoral dissertation]. Texas A&M University; 2018. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1969.1/173936.

Council of Science Editors:

Daviano AC. Variables Associated with the Receipt of Blood Transfusions Among Critical Pediatric Trauma Patients at a Single Level 1 Trauma Center, Houston, Texas - 2011 to 2016. [Doctoral Dissertation]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/173936

University of Toronto

29. Nascimento, Bartolomeu Jr. Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/32611

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Cryoprecipitate is commonly used outside guidelines. In trauma, the appropriate cryoprecipitate dose and its impact on plasma fibrinogen levels are unclear. This retrospective study aims… (more)

Subjects/Keywords: Cryoprecipitate transfusion; appropriateness; dosing; trauma; 0564

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nascimento, B. J. (2012). Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/32611

Chicago Manual of Style (16^th Edition):

Nascimento, Bartolomeu Jr. “Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma.” 2012. Masters Thesis, University of Toronto. Accessed April 10, 2021. http://hdl.handle.net/1807/32611.

MLA Handbook (7^th Edition):

Nascimento, Bartolomeu Jr. “Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma.” 2012. Web. 10 Apr 2021.

Vancouver:

Nascimento BJ. Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1807/32611.

Council of Science Editors:

Nascimento BJ. Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/32611

Western Washington University

30. Sigurjonsson, Johann. A Chemoenzymatic Approach to the Synthesis of Hemoglobin Oligomers.

Degree: MS, Chemistry, 2018, Western Washington University

URL: https://doi.org/10.25710/gdsw-8274 ; https://cedar.wwu.edu/wwuet/750

► Polymerized hemoglobin (poly-Hb) molecules have been shown to have reduced toxicity compared to cell-free hemoglobins when transfused intravenously. Poly-Hbs are typically generated with non-specific… (more)

Subjects/Keywords: Chemistry; Hemoglobin – Synthesis; Blood – Transfusion; masters theses

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sigurjonsson, J. (2018). A Chemoenzymatic Approach to the Synthesis of Hemoglobin Oligomers. (Masters Thesis). Western Washington University. Retrieved from https://doi.org/10.25710/gdsw-8274 ; https://cedar.wwu.edu/wwuet/750

Chicago Manual of Style (16^th Edition):

Sigurjonsson, Johann. “A Chemoenzymatic Approach to the Synthesis of Hemoglobin Oligomers.” 2018. Masters Thesis, Western Washington University. Accessed April 10, 2021. https://doi.org/10.25710/gdsw-8274 ; https://cedar.wwu.edu/wwuet/750.

MLA Handbook (7^th Edition):

Sigurjonsson, Johann. “A Chemoenzymatic Approach to the Synthesis of Hemoglobin Oligomers.” 2018. Web. 10 Apr 2021.

Vancouver:

Sigurjonsson J. A Chemoenzymatic Approach to the Synthesis of Hemoglobin Oligomers. [Internet] [Masters thesis]. Western Washington University; 2018. [cited 2021 Apr 10]. Available from: https://doi.org/10.25710/gdsw-8274 ; https://cedar.wwu.edu/wwuet/750.

Council of Science Editors:

Sigurjonsson J. A Chemoenzymatic Approach to the Synthesis of Hemoglobin Oligomers. [Masters Thesis]. Western Washington University; 2018. Available from: https://doi.org/10.25710/gdsw-8274 ; https://cedar.wwu.edu/wwuet/750

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