subject:(Transdermal )

Universiteit Utrecht

1. Goor, R.A. van. Transdermal application of carbimazole, a safe and efficient treatment of feline hyperthyroidism?.

Degree: 2011, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/289356

► Methimazole and carbimazole, two blockers of the thyroid hormones synthesis, are used for the medical management of feline hyperthyroidism. Mostly pills are used, but in… (more)

▼ Methimazole and carbimazole, two blockers of the thyroid hormones synthesis, are used for the medical management of feline hyperthyroidism. Mostly pills are used, but in the Netherlands a carbimazole-ointment is produced for non-cooperative cats to administer in the inner pinnae of the ears. Our first goal was to find out the way of absorption, via transdermal or oral route. In the first part of the study the transdermal absorption of this ointment is studied in six healthy cats. During the first treatment week potential grooming of the cats was inhibited by wearing an e-collar. After a week of washout the spreading of the ointment was tracked for another treatment week by treatment with a dye-coloured ointment without the e-collar. The cats were both weeks treated with 5 mg carbimazole every 12 h, alternating the nonhaired portion of the left and the right inner pinna. Serum methimazole concentrations were measured on day 1 (t=1, 6 and 12 h) and day 7 (t=1, 6 and 12 h) in the two treatment weeks. One extra blood sample was taken on t=0 of day 1 in the second treatment week. The average serum methimazole concentrations showed a large variation. The average concentration found on day 7 at the third blood sampling (12 h) while the cats were not wearing an e-collar (0.378±0,227 μg/ml) differed significantly from the same sampling times on day 7 (0.167±0.174) and day 1 (0.108±0.077) with e-collar. Also, a spreading of the dye during the week without e-collar was visible at the tongue and around the medial side of both carpi. These results suggest an oral uptake of the ointment with more enteral absorption above transdermal absorption. The other part of the study involved patient visits and interviews. Fifty-seven owners of hyperthyroid cats have been interviewed and twelve of these cats have also been observed after administration of the ointment. The aim of this part was to study the efficacy of the ointment and safety for the (skin of the) owners. All owners saw improvement during treatment with the ointment. Only five owners noted their cat washed the ointment out of the inner pinnae, which would suggest transdermal absorption of the ointment. Twenty cats had changes in the inner pinna as crustae and redness, in nine cats this disappeared while continuance of the treatment. Six of the fifty-seven owners experienced skin problems as redness and itchiness during the treatment with carbimazole. Because of possible skin problems during treatment with carbimazole we recommend to carefully instruct the owners about animal handling, application of the ointment and own skin health while treating the pet. Advisors/Committee Members: Geijlswijk, I.M. van, Kooistra, H.S..

Subjects/Keywords: feline; hyperthyroidism; carbimazole; transdermal; methimazole

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APA (6^th Edition):

Goor, R. A. v. (2011). Transdermal application of carbimazole, a safe and efficient treatment of feline hyperthyroidism?. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/289356

Chicago Manual of Style (16^th Edition):

Goor, R A van. “Transdermal application of carbimazole, a safe and efficient treatment of feline hyperthyroidism?.” 2011. Doctoral Dissertation, Universiteit Utrecht. Accessed January 16, 2021. http://dspace.library.uu.nl:8080/handle/1874/289356.

MLA Handbook (7^th Edition):

Goor, R A van. “Transdermal application of carbimazole, a safe and efficient treatment of feline hyperthyroidism?.” 2011. Web. 16 Jan 2021.

Vancouver:

Goor RAv. Transdermal application of carbimazole, a safe and efficient treatment of feline hyperthyroidism?. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2011. [cited 2021 Jan 16]. Available from: http://dspace.library.uu.nl:8080/handle/1874/289356.

Council of Science Editors:

Goor RAv. Transdermal application of carbimazole, a safe and efficient treatment of feline hyperthyroidism?. [Doctoral Dissertation]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/289356

Rutgers University

2. Shah, Shiv S. Transdermal delivery of insulin: an application of pH sensitive liposomes.

Degree: MS, Chemical and Biochemical Engineering, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/47586/

► Diabetes is a disease where the body either cannot produce insulin (type I) or the cells simply reject the insulin (type II). While type II… (more)

Subjects/Keywords: Transdermal medication; Insulin; Liposomes

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APA (6^th Edition):

Shah, S. S. (2015). Transdermal delivery of insulin: an application of pH sensitive liposomes. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/47586/

Chicago Manual of Style (16^th Edition):

Shah, Shiv S. “Transdermal delivery of insulin: an application of pH sensitive liposomes.” 2015. Masters Thesis, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/47586/.

MLA Handbook (7^th Edition):

Shah, Shiv S. “Transdermal delivery of insulin: an application of pH sensitive liposomes.” 2015. Web. 16 Jan 2021.

Vancouver:

Shah SS. Transdermal delivery of insulin: an application of pH sensitive liposomes. [Internet] [Masters thesis]. Rutgers University; 2015. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47586/.

Council of Science Editors:

Shah SS. Transdermal delivery of insulin: an application of pH sensitive liposomes. [Masters Thesis]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47586/

University of California – Irvine

3. Weidling, John. Transdermal Micro-Implantable Metabolite Sensor with Optical Communication.

Degree: Biomedical Engineering, 2014, University of California – Irvine

URL: http://www.escholarship.org/uc/item/3fv5g1g3

► Early warning of impending shock, organ failure, and hypoperfusion are critical to implementing an effective treatment approach in emergency medicine. However, vital signs often do… (more)

▼ Early warning of impending shock, organ failure, and hypoperfusion are critical to implementing an effective treatment approach in emergency medicine. However, vital signs often do not change until a patient is already in critical condition, and it is too late to intervene effectively. Blood lactate levels have been suggested as a more sensitive parameter for measuring a patient's condition, because lactate levels change early during life-threatening situations such as hemorrhagic shock and sepsis. In fact, frequent serial measurements of lactate over the course of treatment that guide a goal-directed therapy have been shown to decrease mortality rates significantly. Unfortunately, lactate guided treatment is rarely practiced due to the logistical burden of taking serial measurements using point-of-care devices or as part of a lab panel. To address this unmet need, a microchip device to continuously monitor lactate for the duration of inpatient care has been developed. It was found that the microchip could be made such that it is implanted just under the skin surface and an optical probe is used to measure the reported response on the skin surface by passing and receiving light through skin. The microchip responds to changes in lactate concentration by utilizing an enzyme with high specificity and selectivity for lactate. A molecule that reports the enzyme-mediated response is embedded in the microchip. Manufacturing techniques have been developed to reproduce the microchips effectively, and the chips have been tested for use and accuracy in rabbit models of cyanide poisoning, where lactate levels change rapidly. The microchip platform has the ability to be loaded with alternate chemistries for detecting other bio-analytes, such as glucose, oxygen, CO2, pH, etc. An optical probe suitable for passing light through skin and receiving the microchip light emission for use in animal studies was created along with software to analyze the emission signals. When calibrations of implanted chip response to lactate were compared to gold-standard blood lactate measurements across the physiological and pathological range in 12 separate models of cyanide poisoning in rabbits the average error was 11%.

Subjects/Keywords: Biomedical engineering; Biosensor; Implantable; Lactate; Transdermal

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APA (6^th Edition):

Weidling, J. (2014). Transdermal Micro-Implantable Metabolite Sensor with Optical Communication. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/3fv5g1g3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weidling, John. “Transdermal Micro-Implantable Metabolite Sensor with Optical Communication.” 2014. Thesis, University of California – Irvine. Accessed January 16, 2021. http://www.escholarship.org/uc/item/3fv5g1g3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weidling, John. “Transdermal Micro-Implantable Metabolite Sensor with Optical Communication.” 2014. Web. 16 Jan 2021.

Vancouver:

Weidling J. Transdermal Micro-Implantable Metabolite Sensor with Optical Communication. [Internet] [Thesis]. University of California – Irvine; 2014. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/3fv5g1g3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weidling J. Transdermal Micro-Implantable Metabolite Sensor with Optical Communication. [Thesis]. University of California – Irvine; 2014. Available from: http://www.escholarship.org/uc/item/3fv5g1g3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Mishra, Ashish. Formulation and evaluation of transdermal drug delivery system of a few drugs; -.

Degree: Pharmaceutical Sciences, 2012, Veer Narmad South Gujarat University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/45733

None

Bibliography p.161 - 174

Advisors/Committee Members: Patel, C N.

Subjects/Keywords: Evaluation; Formulation; Transdermal

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APA (6^th Edition):

Mishra, A. (2012). Formulation and evaluation of transdermal drug delivery system of a few drugs; -. (Thesis). Veer Narmad South Gujarat University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/45733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mishra, Ashish. “Formulation and evaluation of transdermal drug delivery system of a few drugs; -.” 2012. Thesis, Veer Narmad South Gujarat University. Accessed January 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/45733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mishra, Ashish. “Formulation and evaluation of transdermal drug delivery system of a few drugs; -.” 2012. Web. 16 Jan 2021.

Vancouver:

Mishra A. Formulation and evaluation of transdermal drug delivery system of a few drugs; -. [Internet] [Thesis]. Veer Narmad South Gujarat University; 2012. [cited 2021 Jan 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/45733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mishra A. Formulation and evaluation of transdermal drug delivery system of a few drugs; -. [Thesis]. Veer Narmad South Gujarat University; 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/45733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Jawaharlal Nehru University

5. Misra, Amit. Formulation of transdermal delivery systems for steroids applications for co administration with GnRH Vaccine; -.

Degree: National Institute of Immunology, 1996, Jawaharlal Nehru University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/32277

None

Bibliography p 95-105

Advisors/Committee Members: Singh, Om and Talwar, G P.

Subjects/Keywords: transdermal; Steroids; Gaccine

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APA (6^th Edition):

Misra, A. (1996). Formulation of transdermal delivery systems for steroids applications for co administration with GnRH Vaccine; -. (Thesis). Jawaharlal Nehru University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/32277

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Misra, Amit. “Formulation of transdermal delivery systems for steroids applications for co administration with GnRH Vaccine; -.” 1996. Thesis, Jawaharlal Nehru University. Accessed January 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/32277.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Misra, Amit. “Formulation of transdermal delivery systems for steroids applications for co administration with GnRH Vaccine; -.” 1996. Web. 16 Jan 2021.

Vancouver:

Misra A. Formulation of transdermal delivery systems for steroids applications for co administration with GnRH Vaccine; -. [Internet] [Thesis]. Jawaharlal Nehru University; 1996. [cited 2021 Jan 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/32277.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Misra A. Formulation of transdermal delivery systems for steroids applications for co administration with GnRH Vaccine; -. [Thesis]. Jawaharlal Nehru University; 1996. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/32277

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

6. Kumagai, Miyuki. Evaluation of a Transdermal Drug Delivery System for Veterinary Patients.

Degree: MS, Department of Biomedical Sciences, 2014, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8342

► Canine osteoarthritis (OA) is a progressive degenerative disease often leading to inflammation, pain and disuse of the affected joint. Meloxicam, commonly used to manage canine… (more)

Subjects/Keywords: Canine osteoarthritis; meloxicam; transdermal drug delivery; synovial

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APA (6^th Edition):

Kumagai, M. (2014). Evaluation of a Transdermal Drug Delivery System for Veterinary Patients. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8342

Chicago Manual of Style (16^th Edition):

Kumagai, Miyuki. “Evaluation of a Transdermal Drug Delivery System for Veterinary Patients.” 2014. Masters Thesis, University of Guelph. Accessed January 16, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8342.

MLA Handbook (7^th Edition):

Kumagai, Miyuki. “Evaluation of a Transdermal Drug Delivery System for Veterinary Patients.” 2014. Web. 16 Jan 2021.

Vancouver:

Kumagai M. Evaluation of a Transdermal Drug Delivery System for Veterinary Patients. [Internet] [Masters thesis]. University of Guelph; 2014. [cited 2021 Jan 16]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8342.

Council of Science Editors:

Kumagai M. Evaluation of a Transdermal Drug Delivery System for Veterinary Patients. [Masters Thesis]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8342

North-West University

7. Venter, Telanie. Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne / Telanie Venter .

Degree: 2009, North-West University

URL: http://hdl.handle.net/10394/3984

► Acne is an extremely common condition, affecting almost 80% of adolescents and young adults. It is an inflammatory disease, characterised by comedones, papules, pustules and… (more)

▼ Acne is an extremely common condition, affecting almost 80% of adolescents and young adults. It is an inflammatory disease, characterised by comedones, papules, pustules and sometimes cysts. Factors causing acne include enhanced sebum excretion, hypercornification of the sebaceous duct, ductal coloniazation with Propionibacterium acnes and production of inflammation (Gollnick & Cunliffe, 2003:1). Because of the widespread use of topically applied antimicrobial agents in the treatment of inflammatory acne, resistance of disease-related micro-organisms developed. Therefore new strategies for the treatment of moderate inflammatory acne are necessary. Nicotinamide is a new approach to topical treatment of moderate inflammatory acne without the development of resistant micro-organisms (Otte et al., 2005:257). Using the skin as an alternative route for the administration of nicotinamide for the treatment of acne, may be beneficial. When nicotinamide permeates through the skin, it is directly delivered to the dermis, the place where action is needed and better results can thus be expected after the treatment has started. Another benefit is that smaller amounts of the drug are absorbed systemically with decreased adverse reactions. Unfortunately, using the skin as an alternative route for administering drugs (transdermal drug delivery), has numerous limitations. One of these limitations is the barrier function of the skin (Naik et al., 2000:319). Because of the skin's outstanding ability to protect the body against unwanted substances from its surroundings, it is necessary to use methods to enhance drug penetration through the skin. A new technology, named Pheroid™ technology, was used in this study to enhance penetration through the skin. This technology is based on the use of vesicular structures with no phospholipids or cholesterol to enhance penetration (Grobler et al., 2008:283). The aim of this study was to formulate four different semi-solid formulations with nicotinamide as the active ingredient, and to determine which of the formulations deliver nicotinamide best to the target site. Stability tests over a six months period were also performed on the different formulations. A 3% nicotinamide cream, with and without Pheroid™ vesicles, and a 3% nicotinamide gel, with and without Pheroid™ vesicles, were formulated.

Subjects/Keywords: Nicotinamide; Acne; Transdermal diffusion; Formulation; Stability testing

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APA (6^th Edition):

Venter, T. (2009). Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne / Telanie Venter . (Thesis). North-West University. Retrieved from http://hdl.handle.net/10394/3984

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Venter, Telanie. “Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne / Telanie Venter .” 2009. Thesis, North-West University. Accessed January 16, 2021. http://hdl.handle.net/10394/3984.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Venter, Telanie. “Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne / Telanie Venter .” 2009. Web. 16 Jan 2021.

Vancouver:

Venter T. Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne / Telanie Venter . [Internet] [Thesis]. North-West University; 2009. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10394/3984.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Venter T. Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne / Telanie Venter . [Thesis]. North-West University; 2009. Available from: http://hdl.handle.net/10394/3984

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North-West University

8. Van der Westhuizen, Jani. Formulation, in vitro release and transdermal diffusion of atropine by implementation of the delivery gap principle / Jani van der Westhuizen .

Degree: 2014, North-West University

URL: http://hdl.handle.net/10394/15677

► The transdermal delivery route has become a popular alternative to more conventional routes, such as oral administration, but has not yet reached its full potential… (more)

▼ The transdermal delivery route has become a popular alternative to more conventional routes, such as oral administration, but has not yet reached its full potential (Prausnitz & Langer, 2008:1261). Although the transdermal route proves to have several advantages over the conventional route, the greatest challenge is to overcome the effective barrier of the skin (Jepps et al., 2012:153). The permeation of the active pharmaceutical ingredient (API) through the skin is a complex, multi-step process and therefore predicting the permeability of the API is difficult (Jepps et al., 2012:153; Williams, 2003:30). Various approaches have been developed to overcome the skin barrier and it is recognised that the nature of the vehicle in which the API is applied plays a significant role in promoting transdermal delivery (Foldvari, 2000:417). It is important to consider the fate of the formulation ingredients and the API after application and how this changes the composition of the formulation on the skin when developing a vehicle for transdermal delivery (Lane et al., 2012:496; Otto et al., 2009:2). Wiechers (2012) proposed the Skin Delivery Gap (SDG) as an indicator for the permeability of an API. An API with a SDG < 1 will readily permeate the skin, whilst an SDG > 1 indicates a more complex delivery system is required. The partitioning of the API between the skin and the formulation is influenced by the formulation and by altering the formulation properties it is possible to manipulate the transdermal delivery of the API. The relative polarity index (RPI), based on the octanol-water partition coefficient (log P) of the stratum corneum, formulation and the API, was initially developed by Wiechers as a tool for developing formulations with an optimal polarity, to ensure the transdermal delivery of at least 50% of the API (Lane et al., 2012:498; Wiechers, 2008:94; Wiechers et al., 2004:174). The use of log P as an indicator of polarity was considered impractical by Hansen (2013) and acknowledged by both Wiechers and Abbott, who consequently developed the Formulating for Efficacy™ (FFE™) software which uses Hansen solubility parameters (HSP) instead of log P to indicate polarity (Hansen, 2013). The FFE™ calculates HSP distances, known as gaps, between the skin, API and the formulation to indicate the solubility of the different components in each other. A smaller HSP gap indicates a high solubility. The FFE™ enables the formulator to develop a formulation with a good balance between the active-formulation gap (AFG) and the skin-formulation gap (SFG) to ensure sufficient diffusion of the API into the skin. The FFE™ software was used to develop formulations containing 1.5% atropine as a model drug. Formulations of different polarity (optimised towards the stratum corneum, more hydrophilic and more lipophilic) were developed to determine the effect of the polarity of the formulation and the relevant HSP gaps on the transdermal delivery of the API. The same formulations were utilised for atropine sulphate to determine the effect…

Subjects/Keywords: Transdermal delivery; Formulation; Hansen Solubility Parameters

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APA (6^th Edition):

Van der Westhuizen, J. (2014). Formulation, in vitro release and transdermal diffusion of atropine by implementation of the delivery gap principle / Jani van der Westhuizen . (Thesis). North-West University. Retrieved from http://hdl.handle.net/10394/15677

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Van der Westhuizen, Jani. “Formulation, in vitro release and transdermal diffusion of atropine by implementation of the delivery gap principle / Jani van der Westhuizen .” 2014. Thesis, North-West University. Accessed January 16, 2021. http://hdl.handle.net/10394/15677.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Van der Westhuizen, Jani. “Formulation, in vitro release and transdermal diffusion of atropine by implementation of the delivery gap principle / Jani van der Westhuizen .” 2014. Web. 16 Jan 2021.

Vancouver:

Van der Westhuizen J. Formulation, in vitro release and transdermal diffusion of atropine by implementation of the delivery gap principle / Jani van der Westhuizen . [Internet] [Thesis]. North-West University; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10394/15677.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Van der Westhuizen J. Formulation, in vitro release and transdermal diffusion of atropine by implementation of the delivery gap principle / Jani van der Westhuizen . [Thesis]. North-West University; 2014. Available from: http://hdl.handle.net/10394/15677

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

9. Quinlan, Nathan J. Gas and particle dynamics in transdermal powdered drug delivery.

Degree: PhD, 1999, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:f6a9a058-911a-43c5-bc19-95dc866543df ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302279

► Transdermal powdered drug delivery is an emerging technology for the injection of drugs through human skin, in which particles of solid drug are entrained in… (more)

Subjects/Keywords: 532; Transdermal medication

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APA (6^th Edition):

Quinlan, N. J. (1999). Gas and particle dynamics in transdermal powdered drug delivery. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:f6a9a058-911a-43c5-bc19-95dc866543df ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302279

Chicago Manual of Style (16^th Edition):

Quinlan, Nathan J. “Gas and particle dynamics in transdermal powdered drug delivery.” 1999. Doctoral Dissertation, University of Oxford. Accessed January 16, 2021. http://ora.ox.ac.uk/objects/uuid:f6a9a058-911a-43c5-bc19-95dc866543df ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302279.

MLA Handbook (7^th Edition):

Quinlan, Nathan J. “Gas and particle dynamics in transdermal powdered drug delivery.” 1999. Web. 16 Jan 2021.

Vancouver:

Quinlan NJ. Gas and particle dynamics in transdermal powdered drug delivery. [Internet] [Doctoral dissertation]. University of Oxford; 1999. [cited 2021 Jan 16]. Available from: http://ora.ox.ac.uk/objects/uuid:f6a9a058-911a-43c5-bc19-95dc866543df ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302279.

Council of Science Editors:

Quinlan NJ. Gas and particle dynamics in transdermal powdered drug delivery. [Doctoral Dissertation]. University of Oxford; 1999. Available from: http://ora.ox.ac.uk/objects/uuid:f6a9a058-911a-43c5-bc19-95dc866543df ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302279

Drexel University

10. Bawiec, Christopher R. Interaction of non-thermal, non-cavitational 20-100 kHz ultrasound and biological tissue: modeling and experimental validation.

Degree: 2015, Drexel University

URL: http://hdl.handle.net/1860/idea:6983

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The primary goal of this work was to develop and verify a semi-empirical model that is capable of elucidating the mechanisms of interaction between low… (more)

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The primary goal of this work was to develop and verify a semi-empirical model that is capable of elucidating the mechanisms of interaction between low frequency (20 kHz), low pressure amplitude (55 kPa peak-peak) - corresponding to intensity equal to100 mW/cm2 ((ISPTP), spatial peak, temporal peak) - ultrasound and biological tissue. The novelty of this experimentally confirmed investigation is that it is the first relevant systematic approach examining such interaction. The interaction is of substantial clinical importance as it enables wound management (accelerated healing of chronic wounds) and non-invasive transdermal drug delivery at ultrasound energy levels, which are considered safe for prolonged exposure by the FDA. Specifically, as evidenced in the following the intentional use of low-intensity of 100 mW/cm2, spatial-peak temporal-peak (ISPTP), rules out potentially hazardous mechanisms of interaction such as inertial cavitation and thermal heating. Modeling and experimental verification were based on the novel design of a lightweight (<100g), fully wearable, tether-free, and rechargeable battery powered ultrasound applicator that enables safe outpatient care. Furthermore, this thesis contributed to enhanced understanding of the mechanical forces generated by the applicator and the analysis procedure developed permits an estimation of the magnitude of these forces generated within tissue. The outcome of the modeling indicates that the possible mechanisms of action are most likely associated with non-thermal, non-inertial cavitational effects. The in vitro and in vivo results of this study corroborate that the ultrasound applicator developed is capable of accelerating the healing process of chronic wounds, such as venous- and diabetic ulcers and can also enhance the efficiency of noninvasive, transdermal delivery of topically applied drugs.

Ph.D., Biomedical Engineering – Drexel University, 2015

Advisors/Committee Members: Lewin, Peter A., School of Biomedical Engineering, Science, and Health Systems.

Subjects/Keywords: Biomedical engineering; Transdermal medication; Ultrasound contrast media

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APA (6^th Edition):

Bawiec, C. R. (2015). Interaction of non-thermal, non-cavitational 20-100 kHz ultrasound and biological tissue: modeling and experimental validation. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:6983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bawiec, Christopher R. “Interaction of non-thermal, non-cavitational 20-100 kHz ultrasound and biological tissue: modeling and experimental validation.” 2015. Thesis, Drexel University. Accessed January 16, 2021. http://hdl.handle.net/1860/idea:6983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bawiec, Christopher R. “Interaction of non-thermal, non-cavitational 20-100 kHz ultrasound and biological tissue: modeling and experimental validation.” 2015. Web. 16 Jan 2021.

Vancouver:

Bawiec CR. Interaction of non-thermal, non-cavitational 20-100 kHz ultrasound and biological tissue: modeling and experimental validation. [Internet] [Thesis]. Drexel University; 2015. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1860/idea:6983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bawiec CR. Interaction of non-thermal, non-cavitational 20-100 kHz ultrasound and biological tissue: modeling and experimental validation. [Thesis]. Drexel University; 2015. Available from: http://hdl.handle.net/1860/idea:6983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

11. Dai, Zheng. A nonlinear pharmacokinetic model used in calibrating a transdermal alcohol transport concentration biosensor data analysis software.

Degree: MS, Applied Mathematics, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/453438/rec/279

► In Rosen's earlier work [1] [4], blood (BAC) or breath (BrAC) alcohol concentration was estimated from biosensor measurements of transdermal alcohol concentration (TAC) by forward… (more)

Subjects/Keywords: nonlinear pharmacokinetic model; transdermal alcohol transport

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APA (6^th Edition):

Dai, Z. (2014). A nonlinear pharmacokinetic model used in calibrating a transdermal alcohol transport concentration biosensor data analysis software. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/453438/rec/279

Chicago Manual of Style (16^th Edition):

Dai, Zheng. “A nonlinear pharmacokinetic model used in calibrating a transdermal alcohol transport concentration biosensor data analysis software.” 2014. Masters Thesis, University of Southern California. Accessed January 16, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/453438/rec/279.

MLA Handbook (7^th Edition):

Dai, Zheng. “A nonlinear pharmacokinetic model used in calibrating a transdermal alcohol transport concentration biosensor data analysis software.” 2014. Web. 16 Jan 2021.

Vancouver:

Dai Z. A nonlinear pharmacokinetic model used in calibrating a transdermal alcohol transport concentration biosensor data analysis software. [Internet] [Masters thesis]. University of Southern California; 2014. [cited 2021 Jan 16]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/453438/rec/279.

Council of Science Editors:

Dai Z. A nonlinear pharmacokinetic model used in calibrating a transdermal alcohol transport concentration biosensor data analysis software. [Masters Thesis]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/453438/rec/279

University of Southern California

12. Coste, Katherine A. Determining blood alcohol concentration from transdermal alcohol data: calibrating a mathematical model using a drinking diary.

Degree: MS, Applied Mathematics, 2013, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/285337/rec/1895

► This research improves the BrAC Estimator software, a MATLAB program designed to produce estimates of blood or breath alcohol concentration (BAC/BrAC) from a sensor measuring… (more)

Subjects/Keywords: BrAC estimation; drinking diary; transdermal alcohol sensor

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APA (6^th Edition):

Coste, K. A. (2013). Determining blood alcohol concentration from transdermal alcohol data: calibrating a mathematical model using a drinking diary. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/285337/rec/1895

Chicago Manual of Style (16^th Edition):

Coste, Katherine A. “Determining blood alcohol concentration from transdermal alcohol data: calibrating a mathematical model using a drinking diary.” 2013. Masters Thesis, University of Southern California. Accessed January 16, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/285337/rec/1895.

MLA Handbook (7^th Edition):

Coste, Katherine A. “Determining blood alcohol concentration from transdermal alcohol data: calibrating a mathematical model using a drinking diary.” 2013. Web. 16 Jan 2021.

Vancouver:

Coste KA. Determining blood alcohol concentration from transdermal alcohol data: calibrating a mathematical model using a drinking diary. [Internet] [Masters thesis]. University of Southern California; 2013. [cited 2021 Jan 16]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/285337/rec/1895.

Council of Science Editors:

Coste KA. Determining blood alcohol concentration from transdermal alcohol data: calibrating a mathematical model using a drinking diary. [Masters Thesis]. University of Southern California; 2013. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/285337/rec/1895

University of Georgia

13. Israel, Bridg'ette Beatrice. Topical formulations for disease treatment.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/26359

► Purpose: Develop a bioadhesive formulation for the treatment of aquatic life with skin lesions or abrasions. The purpose of the second research project is to… (more)

▼ Purpose: Develop a bioadhesive formulation for the treatment of aquatic life with skin lesions or abrasions. The purpose of the second research project is to develop novel mutual prodrugs (MP) which couple n-acetyl-glucosamine with NSAID, either ketoprofen or ibuprofen. These mutual prodrugs are designed to aid in the treatment of osteoarthritis. Lastly, the transdermal permeability of N-Acetyl-D-Glucosamine is evaluated for the development of the mutual prodrug. Methods: For research project one, oleaginous gels were prepared and their viscosity measurements were taken with a rheometer to gain information pertaining to the bioadhesive forces present in each formulation. The mutual prodrugs are synthesized for project two. One mutual prodrug links n-acetyl-glucosamine to ketoprofen and the other links n-acetyl-glucosamine to ibuprofen. N-Acetyl-D-Glucosamine solutions were prepared at different concentrations for the third project. Enhancing agents were also incorporated to evaluate their influence on permeability of N-Acetyl-D-Glucosamine. The Franz cell apparatus and High Performance Liquid Chromatography were utilized to collect and analyze samples, respectively. Results: The findings of project one are as follows, gels prepared with safflower oil and wheat germ oil demonstrated the greatest viscosity and perceived bioadhesion when compared to the other gels and all controls. The gel prepared with both safflower oil and wheat germ oil provided the largest inhibition zone. The structure of the oil may be important since both safflower oil and wheat germ oil contain linoleic and linolenic acids, whereas olive oil contains mostly oleic acid. Permeability studies, of project two, show that the ketoprofen mutual prodrug permeates shed snakeskin more than three times greater than either ibuprofen derivative, while ethanol markedly increases the permeation for all three. It was determined, for project three, that the permeability coefficients of the phosphate buffer/ethanol solutions at 5%, 10%, and 25% were about threefold larger in value as those for saturated DMSO solution, whereas the 2% and 50% solution values were lower. Conclusion: The bioadhesive gel prepared with safflower oil showed greatest stickiness to chicken breast, greatest viscosity, and best antimicrobial release (for project one). It was concluded, from the results of project two, that the ketoprofen mutual prodrug appears the most likely candidate for transdermal administration; the ibuprofen mutual prodrugs for oral delivery; all three mutual prodrugs may be candidates for oral delivery or subcutaneous injection. The permeability coefficients calculated, during project three, supports the idea that phosphate buffer/ethanol solutions at 5%, 10%, and 25% are the optimal candidates for formulation while phosphate buffer/ethanol solutions at 2%, 50% contains too little ethanol and saturation has been reached, respectively.

Subjects/Keywords: Bioadhesion; Oleaginous; Transdermal Permeation; Mutual Prodrug; NSAID

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Israel, B. B. (2014). Topical formulations for disease treatment. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/26359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Israel, Bridg'ette Beatrice. “Topical formulations for disease treatment.” 2014. Thesis, University of Georgia. Accessed January 16, 2021. http://hdl.handle.net/10724/26359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Israel, Bridg'ette Beatrice. “Topical formulations for disease treatment.” 2014. Web. 16 Jan 2021.

Vancouver:

Israel BB. Topical formulations for disease treatment. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10724/26359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Israel BB. Topical formulations for disease treatment. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/26359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Florida

14. Shultz, Zachary P. Synthesis, Discovery and Delivery of Therapeutic Natural Products and Analogs.

Degree: 2019, University of South Florida

URL: https://scholarcommons.usf.edu/etd/8415

► Small molecule drug discovery relies heavily on synthetic organic chemistry to develop novel chemical entities that elicit desirable therapeutic effects. The development of targeted chemical… (more)

▼ Small molecule drug discovery relies heavily on synthetic organic chemistry to develop novel chemical entities that elicit desirable therapeutic effects. The development of targeted chemical syntheses is of paramount importance to access molecules for biological evaluation and is usually considered the bottleneck in most drug discovery campaigns. Targets for chemical syntheses commonly draw inspiration from molecules of natural origin. Nature harbors a wealth of chemical diversity that has established itself over millions of years through chemical and biological evolution. Organisms have an inherent ability to protect themselves from predators and harmful environments. In doing so, many of them evolve to produce chemical defenses in order to survive in their environments. Unfortunately, most bioactive natural products are not present in large abundance and require chemical syntheses for evaluation of their therapeutic potential. Antibiotic resistance has become a major health concern that is creating a health and financial burden on society. There is an unmet need to develop new antibiotics to combat the ever-evolving microbes. Drug-resistant bacteria capable of adopting biofilm morphology become increasingly resistant to antibiotic treatment, threatening the life of the patient. A series of marine natural products (MNPs) have recently been identified to exhibit promising activity against methicillin resistant Stahphylococcus aureus (MRSA) biofilms. One of the most potent compounds in the series was the MNP membranolide. The intriguing biological properties of membranolide have led us to develop an enantioselective synthesis of the natural product and related analogs for further evaluation against MRSA biofilms (outlined in chapter 2). Microbial infections are not limited to bacteria. Parasitic and amoebic pathogens can cause infections as well, with the latter being underrepresented in drug discovery. The lack of research and development in the area of amoebic infections may be partly due to the rarity of occurrence. However, some amoebic infections have extremely high mortality rates, such as those caused by Naegleria fowleri, presenting a dire need for new therapeutics. Phytocannabinoid natural products have been found to exhibit anti-proliferation activity against N. fowleri and represent a class of compounds that may aid in the efforts in combatting its infections. A novel chemical synthesis is disclosed in chapter 3 that gives rise to tetrahydrocannabinol (THC) and cannabidiol (CBD) and related analogs to further evaluate and understand their biological activity. Furthermore, these compounds could be effective treatments against a myriad of other clinical indications including but not limited to pain, inflammation, anxiety and even Alzheimer’s disease. The cannabinoids are well-known for their unique biological and physiochemical properties; however, they lack ideal pharmacokinetic profiles to become successful therapeutics. Their poor absorption through traditional delivery routes can be addressed either by…

Subjects/Keywords: cannabinoids; natural products; skin PAMPA; Total synthesis; transdermal delivery; transdermal patch; Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shultz, Z. P. (2019). Synthesis, Discovery and Delivery of Therapeutic Natural Products and Analogs. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/8415

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shultz, Zachary P. “Synthesis, Discovery and Delivery of Therapeutic Natural Products and Analogs.” 2019. Thesis, University of South Florida. Accessed January 16, 2021. https://scholarcommons.usf.edu/etd/8415.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shultz, Zachary P. “Synthesis, Discovery and Delivery of Therapeutic Natural Products and Analogs.” 2019. Web. 16 Jan 2021.

Vancouver:

Shultz ZP. Synthesis, Discovery and Delivery of Therapeutic Natural Products and Analogs. [Internet] [Thesis]. University of South Florida; 2019. [cited 2021 Jan 16]. Available from: https://scholarcommons.usf.edu/etd/8415.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shultz ZP. Synthesis, Discovery and Delivery of Therapeutic Natural Products and Analogs. [Thesis]. University of South Florida; 2019. Available from: https://scholarcommons.usf.edu/etd/8415

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Indian Institute of Science

15. Vinaya Kumar, K B. Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System.

Degree: PhD, Engineering, 2018, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/4092

► Transdermal drug delivery is the most preferred drug delivery method, due to its high efficiency and less side effects. In conventional transdermal drug delivery, the… (more)

▼ Transdermal drug delivery is the most preferred drug delivery method, due to its high efficiency and less side effects. In conventional transdermal drug delivery, the delivery of macromolecular drugs (ex: Insulin, vaccines etc.) is limited by skin barrier. Several possible approaches have been proposed to overcome this limitation (chemical, electrical, ultrasound, microneedle etc.). Among these, the microneedle approach is considered as one of the best method to improve the effective delivery of drug. These microneedles penetrate into the outermost skin layers namely stratum corneum and epidermis. The thickness of the above mentioned skin layers will impose the constraints on the design of microneedle for the successful delivery of drug. On the other hand, along with the microneedle, the micropump is one more important functional module essential for a continuous drug delivery application such as insulin delivery for diabetic patients. The aim of the present work is to improve the transdermal drug delivery using microneedle and micropump technology. Details on the fabrication, evaluation of both solid and hollow microneedle structures have been presented. Issues such as penetration reliability, liquid delivery into the skin and microneedle packaging are also discussed. Peristaltic micropump was developed to achieve a controlled flow of drug through the microneedle array. The developed micropump was successfully characterized to meet the typical drug delivery pump requirements such as: fail-safe mechanisms, adequate delivery of drug against blood pressure, ease of tubing and flow control over wide range. The micropump was integrated with necessary electronics and characterized for the complete drug delivery operation. Finally, the microneedle and micropump -based system was tested and studied in vivo for insulin delivery. Results obtained were compared with the standard subcutaneous delivery with the same dose rate and found that they are in good agreement. The thesis is divided into seven chapters. Chapter 1 The present chapter discusses a general brief introduction along with literature survey about microneedle and micropump for drug delivery applications. Information on fabrication of the microneedle array using different methods and their characterization to improve the transdermal drug delivery has been discussed. It also includes the information on the usage of micropump in drug delivery application. Chapter 2 This chapter discusses the design, fabrication and characterization of cup shaped solid silicon microneedle array for leak proof drug delivery application. The mechanical stability of the fabricated microneedle to insert into the skin has been studied. The drug filled cup shaped microneedles were inserted into mice skin and drug dissolution was confirmed using fluorescence imaging technique. Chapter 3 In this chapter, details on the fabrication of out-of-plane Si microneedle array using both isotropic and anisotropic etching processes has been presented. The fabricated microneedles were… Advisors/Committee Members: Rajanna, K (advisor), Dinesh, N S (advisor).

Subjects/Keywords: Transdermal Drug Delivery System; Microneedle; Micropump; Biomedical Engineering; Transdermal Drug Delivery; Microneedle Array; Microneedles; Micropump-based System; Instrumentation and Applied Physics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vinaya Kumar, K. B. (2018). Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/4092

Chicago Manual of Style (16^th Edition):

Vinaya Kumar, K B. “Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed January 16, 2021. http://etd.iisc.ac.in/handle/2005/4092.

MLA Handbook (7^th Edition):

Vinaya Kumar, K B. “Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System.” 2018. Web. 16 Jan 2021.

Vancouver:

Vinaya Kumar KB. Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Jan 16]. Available from: http://etd.iisc.ac.in/handle/2005/4092.

Council of Science Editors:

Vinaya Kumar KB. Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/4092

Universidad Nacional de La Plata

16. Ferrante, Marcos. Desarrollo de una formulación topica de diclofenac para uso en equinos.

Degree: 2012, Universidad Nacional de La Plata

URL: http://sedici.unlp.edu.ar/handle/10915/20897 ; https://doi.org/10.35537/10915/20897

►

Diclofenac es un antiinflamatorio no esteroide ampliamente utilizado en humanos y animales. Estudios anteriores han demostrado que este compuesto tiene una baja difusión percutánea en… (more)

▼

Diclofenac es un antiinflamatorio no esteroide ampliamente utilizado en humanos y animales. Estudios anteriores han demostrado que este compuesto tiene una baja difusión percutánea en equinos. Se estudiaron cuatro aumentadores de la penetración (urea al 10%, ácido oleico al 15% y 20% y D-limoneno al 5% y 10%) y el efecto sinérgico de la asociación de urea al 10% y ácido oleico al 15 y 20 % con 20% propilenglicol sobre la difusión percutánea de diclofenac dietilamina a través de piel equina. Para la evaluación comparativa de las formulaciones desarrolladas, se estudió (a) la liberación del principio activo desde la formulación con el aparato 5 de la USP (paleta sobre disco), (b) la penetración in vitro de diclofenac dietilamina a través de piel equina mediante celdas de tipo Franz y (c) el efecto antiinflamatorio de las diferentes formulaciones a través de la cuantificación de la inhibición de la formación de edema tras la inyección intradérmica de carragenina 0.25%. Todas las formulaciones se liberaron de manera adecuada, no observándose diferencias estadísticamente significativas entre ellas. Urea al 10%, D-limoneno al 10% y ácido oleico al 15% indujeron un aumento significativo de la penetración; ninguna de las formulaciones modificó el tiempo Lag. Acido oleico 15% indujo el mayor flujo de penetración y la mayor actividad antiedematosa. Finalmente, el efecto clínico antiinflamatorio y analgésico de esta formulación fue evaluado con un modelo de artritis aguda endotóxica inducida con LPS (E. coli O55:B5). Los parámetros clínicos mensurados fueron circunferencia carpiana, temperatura corporal, largo de paso, ángulo en estación y ángulo en flexión. La eficacia clínica de la formulación desarrollada fue demostrada a través de los cambios en el ángulo en flexión máxima, reflejando el potente efecto analgésico de la misma. Este trabajo de tesis describe por primera vez efectos de los aumentadores de la penetración in vitro de diclofenac dietilamina a través de la piel equina. Asimismo, demuestra que la formulación transdérmica de diclofenac dietilamina con acido oleico 15% desarrollada posee un flujo de penetración suficiente como para generar un efecto antiedematoso y analgésico clínicamente evidente en equinos.

Diclofenac is a widely used NSAID in humans and animals. Previous studies have shown that this compound has a low percutaneous diffusion in horses. We studied four penetration enhancers (urea 10%, 15% and 20% oleic acid and 5% and 10% Dlimonene) also, the synergistic effect of the association of 10%urea and 15 and 20% oleic acid with 20% propylene glycol on percutaneous diffusion of diclofenac diethylamine through equine skin was evaluated. For benchmarking formula, was studied (a) the release of the active ingredient from the formulation with the USP apparatus 5 (paddle over disk), (b) in vitro penetration of diclofenac diethylamine through equine skin by Franz-type cells and (c) the antiinflammatory effect of different formulations through the quantification of inhibition of oedema formation…

Advisors/Committee Members: Landoni, María Fabiana, Andreetta, Héctor Alfredo.

Subjects/Keywords: Veterinaria; Farmacia; Farmacología; administración transdermal; Agentes Antiinflamatorios; diclofenac; aumentadores de la penetración; Equino; transdermal administration; penetration enhancers; equine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferrante, M. (2012). Desarrollo de una formulación topica de diclofenac para uso en equinos. (Thesis). Universidad Nacional de La Plata. Retrieved from http://sedici.unlp.edu.ar/handle/10915/20897 ; https://doi.org/10.35537/10915/20897

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferrante, Marcos. “Desarrollo de una formulación topica de diclofenac para uso en equinos.” 2012. Thesis, Universidad Nacional de La Plata. Accessed January 16, 2021. http://sedici.unlp.edu.ar/handle/10915/20897 ; https://doi.org/10.35537/10915/20897.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferrante, Marcos. “Desarrollo de una formulación topica de diclofenac para uso en equinos.” 2012. Web. 16 Jan 2021.

Vancouver:

Ferrante M. Desarrollo de una formulación topica de diclofenac para uso en equinos. [Internet] [Thesis]. Universidad Nacional de La Plata; 2012. [cited 2021 Jan 16]. Available from: http://sedici.unlp.edu.ar/handle/10915/20897 ; https://doi.org/10.35537/10915/20897.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferrante M. Desarrollo de una formulación topica de diclofenac para uso en equinos. [Thesis]. Universidad Nacional de La Plata; 2012. Available from: http://sedici.unlp.edu.ar/handle/10915/20897 ; https://doi.org/10.35537/10915/20897

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

17. Andrews, Samantha Nacole. Microdermabrasion for transdermal drug delivery.

Degree: PhD, Biomedical Engineering, 2010, Georgia Tech

URL: http://hdl.handle.net/1853/37150

► The skin serves as a semi-permeable barrier that protects the body from pathogens and water loss. The stratum corneum, the upper 10-15 µm layer of… (more)

Subjects/Keywords: Microdermabrasion; Transdermal drug delivery; Skin; Transdermal medication

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Andrews, S. N. (2010). Microdermabrasion for transdermal drug delivery. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/37150

Chicago Manual of Style (16^th Edition):

Andrews, Samantha Nacole. “Microdermabrasion for transdermal drug delivery.” 2010. Doctoral Dissertation, Georgia Tech. Accessed January 16, 2021. http://hdl.handle.net/1853/37150.

MLA Handbook (7^th Edition):

Andrews, Samantha Nacole. “Microdermabrasion for transdermal drug delivery.” 2010. Web. 16 Jan 2021.

Vancouver:

Andrews SN. Microdermabrasion for transdermal drug delivery. [Internet] [Doctoral dissertation]. Georgia Tech; 2010. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1853/37150.

Council of Science Editors:

Andrews SN. Microdermabrasion for transdermal drug delivery. [Doctoral Dissertation]. Georgia Tech; 2010. Available from: http://hdl.handle.net/1853/37150

Texas A&M University

18. Padgett, Ashley Loren. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.

Degree: MS, Biomedical Sciences, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/174041

► Designing perioperative analgesic regimen for ruminants is problematic as pain assessment is difficult and pregnancy adds additional considerations. The aim of this study was to… (more)

▼ Designing perioperative analgesic regimen for ruminants is problematic as pain assessment is difficult and pregnancy adds additional considerations. The aim of this study was to assess the nociceptive properties of intramuscularly administered buprenorphine and transdermally administered fentanyl utilizing a composite pain score system. To better confirm that the observed abnormal behavior was related to pain, the current study attempted to characterize the nociceptive properties of the analgesic agents at a given plasma drug concentration, which has not previously been done. Additionally, the study characterized transplacental movement of analgesic agents via fetal plasma drug concentrations. In this study, we compared intramuscularly administered buprenorphine at a dose of 0.01 mg/kg every 8 hours for 48 hours starting at induction for surgery (n=6) to transdermal fentanyl patches (n=6) applied in the dorsal thorax region 24 hours before surgery at a dose of 2μg/kg/hr for postoperative pain. Ewe blood samples were collected and signs of pain and sedation were measured 24 hours before surgery (time -24), induction to surgery (time 0), and 2, 4, 6, 8, 12, 24, 36, 48 hours after. Using an indwelling fetal arterial catheter that was placed during the surgery, fetal blood pressure was recorded and blood samples were collected. Drug concentrations were measured in maternal and fetal plasma and amniotic fluid. The buprenorphine treated ewes exhibited more pain consistent behaviors than those treated with fentanyl, and their postoperative pain scores were significantly higher than the preoperative value. There were also significant differences in cardiovascular variables from the anesthesia records between the two groups. Overall, transdermal administration of fentanyl provided adequate analgesia with little adverse effects, making it a candidate for optimal postoperative pain management in sheep. Advisors/Committee Members: Washburn, Shannon E (advisor), Lepiz, Mauricio L (committee member), Fajt, Virginia R (committee member), Patterson, Carly (committee member).

Subjects/Keywords: transdermal fentanyl; opioids; pregnant sheep; buprenorphine; analgesia; anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Padgett, A. L. (2018). Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/174041

Chicago Manual of Style (16^th Edition):

Padgett, Ashley Loren. “Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.” 2018. Masters Thesis, Texas A&M University. Accessed January 16, 2021. http://hdl.handle.net/1969.1/174041.

MLA Handbook (7^th Edition):

Padgett, Ashley Loren. “Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.” 2018. Web. 16 Jan 2021.

Vancouver:

Padgett AL. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1969.1/174041.

Council of Science Editors:

Padgett AL. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/174041

University of Johannesburg

19. Proctor, Matthew Charles. The effect of spinal manipulative therapy in conjunction with transcutaneous flurbiprofen in the treatment of mechanical low back pain.

Degree: 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/4799

►

M.Tech.

Purpose: This study aims to compare the effects of spinal manipulative therapy to the lumbar spine and/or pelvis, and spinal manipulative therapy to the… (more)

Subjects/Keywords: Spinal adjustment; Backache - Chiropractic treatment; Transcutaneous flurbiprofen; Transdermal medication

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APA (6^th Edition):

Proctor, M. C. (2012). The effect of spinal manipulative therapy in conjunction with transcutaneous flurbiprofen in the treatment of mechanical low back pain. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/4799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Proctor, Matthew Charles. “The effect of spinal manipulative therapy in conjunction with transcutaneous flurbiprofen in the treatment of mechanical low back pain.” 2012. Thesis, University of Johannesburg. Accessed January 16, 2021. http://hdl.handle.net/10210/4799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Proctor, Matthew Charles. “The effect of spinal manipulative therapy in conjunction with transcutaneous flurbiprofen in the treatment of mechanical low back pain.” 2012. Web. 16 Jan 2021.

Vancouver:

Proctor MC. The effect of spinal manipulative therapy in conjunction with transcutaneous flurbiprofen in the treatment of mechanical low back pain. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10210/4799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Proctor MC. The effect of spinal manipulative therapy in conjunction with transcutaneous flurbiprofen in the treatment of mechanical low back pain. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/4799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Modi, C D. Design and development of transfersomes loaded with dmards for autoimmune disorders via transdermal drug delivery; -.

Degree: Pharmaceutical Sciences, 2014, Hemchandracharya North Gujarat University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/44222

Abstract available

n.d.

Advisors/Committee Members: Bharadia, P D.

Subjects/Keywords: Design; Development; Transdermal; Transfersomes

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APA (6^th Edition):

Modi, C. D. (2014). Design and development of transfersomes loaded with dmards for autoimmune disorders via transdermal drug delivery; -. (Thesis). Hemchandracharya North Gujarat University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/44222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Modi, C D. “Design and development of transfersomes loaded with dmards for autoimmune disorders via transdermal drug delivery; -.” 2014. Thesis, Hemchandracharya North Gujarat University. Accessed January 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/44222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Modi, C D. “Design and development of transfersomes loaded with dmards for autoimmune disorders via transdermal drug delivery; -.” 2014. Web. 16 Jan 2021.

Vancouver:

Modi CD. Design and development of transfersomes loaded with dmards for autoimmune disorders via transdermal drug delivery; -. [Internet] [Thesis]. Hemchandracharya North Gujarat University; 2014. [cited 2021 Jan 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/44222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Modi CD. Design and development of transfersomes loaded with dmards for autoimmune disorders via transdermal drug delivery; -. [Thesis]. Hemchandracharya North Gujarat University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/44222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Shah, Hiral J. Studies on development and evaluation of enhanced transdermal controlled drug delivery of selected analgesic drugs; -.

Degree: Pharmaceutical Sciences, 2014, Hemchandracharya North Gujarat University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/44240

Abstract available

Appendix given

Advisors/Committee Members: Bharadia, P D.

Subjects/Keywords: Development; Drug delivery; Studies; Transdermal

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APA (6^th Edition):

Shah, H. J. (2014). Studies on development and evaluation of enhanced transdermal controlled drug delivery of selected analgesic drugs; -. (Thesis). Hemchandracharya North Gujarat University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/44240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shah, Hiral J. “Studies on development and evaluation of enhanced transdermal controlled drug delivery of selected analgesic drugs; -.” 2014. Thesis, Hemchandracharya North Gujarat University. Accessed January 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/44240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shah, Hiral J. “Studies on development and evaluation of enhanced transdermal controlled drug delivery of selected analgesic drugs; -.” 2014. Web. 16 Jan 2021.

Vancouver:

Shah HJ. Studies on development and evaluation of enhanced transdermal controlled drug delivery of selected analgesic drugs; -. [Internet] [Thesis]. Hemchandracharya North Gujarat University; 2014. [cited 2021 Jan 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/44240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shah HJ. Studies on development and evaluation of enhanced transdermal controlled drug delivery of selected analgesic drugs; -. [Thesis]. Hemchandracharya North Gujarat University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/44240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rhodes University

22. Magnus, Ashley Denis. Aspects of the bioavailability of topical corticosteroid formulations.

Degree: Faculty of Pharmacy, Pharmacy, 2013, Rhodes University

URL: http://hdl.handle.net/10962/d1009516

►

Two possible variables of the McKenzie/Stoughton blanching assay, namely amount applied to the test site and occlusion time have been investigated. Subsequently, two topical steroid… (more)

Subjects/Keywords: Adrenocortical hormones – Therapeutic use; Dermatologic agents; Transdermal medication – Evaluation; Dermatopharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Magnus, A. D. (2013). Aspects of the bioavailability of topical corticosteroid formulations. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1009516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Magnus, Ashley Denis. “Aspects of the bioavailability of topical corticosteroid formulations.” 2013. Thesis, Rhodes University. Accessed January 16, 2021. http://hdl.handle.net/10962/d1009516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Magnus, Ashley Denis. “Aspects of the bioavailability of topical corticosteroid formulations.” 2013. Web. 16 Jan 2021.

Vancouver:

Magnus AD. Aspects of the bioavailability of topical corticosteroid formulations. [Internet] [Thesis]. Rhodes University; 2013. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10962/d1009516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Magnus AD. Aspects of the bioavailability of topical corticosteroid formulations. [Thesis]. Rhodes University; 2013. Available from: http://hdl.handle.net/10962/d1009516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

23. Rambharose, Sanjeev Kumar. Novel lipidic materials to enhance the transdermal delivery of tenofovir.

Degree: 2017, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/18500

► The global burden of HIV and AIDS coupled with the limitations of current oral tenofovir (TNF) administration drives the need to develop strategies such as… (more)

▼ The global burden of HIV and AIDS coupled with the limitations of current oral tenofovir (TNF) administration drives the need to develop strategies such as the use of alternate routes of administration to improve drug therapy. Transdermal drug delivery (TDD) offers numerous advantages and is an attractive alternative for the systemic delivery of TNF. Although the inherent protective barrier property of skin is one of the major challenges in the design of TDD systems, the use of chemical permeation enhancers (CPEs) such as fatty acids (FA) and their esters or the use of nano drug delivery systems have the potential to overcome this limitation. To date there are no reports on TDD permeation enhancement strategies or a nanoemulgel (NEG) as a TDD formulation for TNF. Novel lipidic approaches that reversibly decrease the barrier properties of the skin as well as the use lipid based nano drug delivery systems such as NEGs to enhance the TDD of TNF remain to be investigated. The broad aim of this study was therefore to explore the potential of novel lipid-based strategies for enhancing transdermal permeation of TNF. The specific research aims of this study were to: (1) Synthesize and characterize novel biocompatible dendritic ester derivatives of unsaturated FAs (UFAs) and explore their potential as promising permeation enhancers for the transdermal delivery of TNF. (2) Evaluate the novel application of UFA esters of cholesterol as promising transdermal permeation enhancers using TNF as a model drug. (3) Synthesize and characterize novel biocompatible mono, di and tri-ester derivatives of FAs and explore their potential as promising transdermal permeation enhancers using TNF as a model drug. (4) Explore the potential of novel linolenic acid based heterolipid, LLA1E (a novel transdermal permeation enhancer), as an oily phase in the development of a nanoemulgel for the transdermal drug delivery of TNF. UFAs [palmitoleic (PA), linoleic (LA), linolenic (LLA) and arachidonic acid (AA)] were used to synthesize novel dendritic ester derivatives [PA1E, LA1E, LLA1E and AA1E]. The structural features of the biosafe derivatives were confirmed by FTIR, NMR (1H and 13C) and HRMS. All synthesized novel dendritic ester derivatives at 1% w/w were found to be more effective enhancers with LLA1E being identified as the most superior with an ER of 6.11 at 2% w/w. Histomorphological analysis displayed no significant loss in the integrity of the skin and also indicated that TNF utilized both the transcellular and intercellular route of transport, with the drug and enhancer treatment having no permanent effects on the epidermis. Therefore these novel dendritic ester derivatives of UFAs can be considered as effective transdermal permeation enhancers for TNF. The TDD potential of TNF using UFA esters of Cholesterol (Chol) viz., oleate, linoleate and linolenate, as CPEs showed that all Chol UFA esters at 1% w/w were found to be more effective enhancers when compared to their respective parent FAs and saturated FAs counterparts. Cholesteryl… Advisors/Committee Members: Govender, Thirumala. (advisor).

Subjects/Keywords: Transdermal drug delivery.; Tenofovir.; Fatty acids.; Drug therapy.; Skin.; Nanoemulsion.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rambharose, S. K. (2017). Novel lipidic materials to enhance the transdermal delivery of tenofovir. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/18500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rambharose, Sanjeev Kumar. “Novel lipidic materials to enhance the transdermal delivery of tenofovir.” 2017. Thesis, University of KwaZulu-Natal. Accessed January 16, 2021. https://researchspace.ukzn.ac.za/handle/10413/18500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rambharose, Sanjeev Kumar. “Novel lipidic materials to enhance the transdermal delivery of tenofovir.” 2017. Web. 16 Jan 2021.

Vancouver:

Rambharose SK. Novel lipidic materials to enhance the transdermal delivery of tenofovir. [Internet] [Thesis]. University of KwaZulu-Natal; 2017. [cited 2021 Jan 16]. Available from: https://researchspace.ukzn.ac.za/handle/10413/18500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rambharose SK. Novel lipidic materials to enhance the transdermal delivery of tenofovir. [Thesis]. University of KwaZulu-Natal; 2017. Available from: https://researchspace.ukzn.ac.za/handle/10413/18500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

24. Wells, Sarah. Development of a transdermal patch using fabrics .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/4082

► Atopic dermatitis is a major public health problem worldwide. It has a wide clinical spectrum ranging from minor forms such as dry, depigmented patches (pityraisis… (more)

▼ Atopic dermatitis is a major public health problem worldwide. It has a wide clinical spectrum ranging from minor forms such as dry, depigmented patches (pityraisis alba), to major forms with erythrodermic rash, with the rash being slightly more common in boys (Beiber and Prolss, 2008). The age of onset is generally 2-6 months. Several treatments are available for atopic dermatitis including: oral corticosteroids, topical corticosteroids, calcineurin inhibitors and antibiotics. Given orally, corticosteroids can have permanent and severe side effects (e.g. Cushing’s syndrome). Topical or transdermal drug delivery is preferred over oral treatments because it allows prolonged continuous and consistent release of the drug into the systemic circulation, direct drug release to the target area, and the ability to avoid first-pass gastrointestinal and hepatic metabolism to minimise adverse effects. At the time of this study, at least two textiles had been developed for the treatment of atopic dermatitis: DermaSilk® and Padycare®. Both these fabrics have antimicrobial finishes which treat the secondary bacterial infection generally present on the erythrodermic rash. Previous studies have shown that both fabrics are effective in treating the rash present in atopic dermatitis. However, at the time of the current study DermaSilk® was not commonly available in New Zealand and was expensive, therefore it was not a viable option for wide use. The other fabric available, Padycare®, was made from silver filaments. Silver had been shown to have potential side effects to humans and the environment. Thus, there was a need for an inexpensive, safe, readily available dermal treatment for atopic dermatitis. The purpose of the current study was to design a cotton and silk transdermal patch for the treatment of atopic dermatitis and to study the relevant physical properties of these fabrics. The mass, thickness, air permeability, water vapour permeability and LAC of the fabrics were measured. The fabric specimens were then immersed in one of the two different concentrations (5mg/ml and 10mg/ml) of hydrocortisone and ethanol solutions for two minutes. The specimens were then dried and physical properties re-measured. FTIR, XRPD and SEM were performed to determine whether the hydrocortisone adhered to the fabric and if so in what solid state form (amphorous or crystalline). The physical properties of the fabrics differed from each other but both would be suitable for a transdermal patch in the treatment of atopic dermatitis. The physical properties of the fabrics did not differ after immersion compared to before. FTIR and XRPD did not show any difference between the non-treated, 5mg/ml and 10mg/ml specimens. Neither FTIR nor XRPD showed any difference between the non-treated and the pipetted samples; therefore both instruments may not have been able to detect small amounts of hydrocortisone on the fabrics. SEM confirmed that there was no visible evidence of hydrocortisone on specimens immersed in either of the two concentrations tested,… Advisors/Committee Members: Laing, Raechel (advisor).

Subjects/Keywords: Atopic dermatitis; Hydrocortisone; Cotton; Silk; Topical/transdermal drug delivery

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APA (6^th Edition):

Wells, S. (2013). Development of a transdermal patch using fabrics . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/4082

Chicago Manual of Style (16^th Edition):

Wells, Sarah. “Development of a transdermal patch using fabrics .” 2013. Masters Thesis, University of Otago. Accessed January 16, 2021. http://hdl.handle.net/10523/4082.

MLA Handbook (7^th Edition):

Wells, Sarah. “Development of a transdermal patch using fabrics .” 2013. Web. 16 Jan 2021.

Vancouver:

Wells S. Development of a transdermal patch using fabrics . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10523/4082.

Council of Science Editors:

Wells S. Development of a transdermal patch using fabrics . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/4082

New Jersey Institute of Technology

25. Falcone, Roberto P. New screening methodology for selection of polymeric materials for transdermal drug delivery devices.

Degree: PhD, Committee for the Interdisciplinary Program in Materials Science and Engineering, 2015, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/dissertations/116

► As medical advances extend the human lifespan, the level of chronic illnesses will increase and thus straining the needs of the health care system… (more)

▼ As medical advances extend the human lifespan, the level of chronic illnesses will increase and thus straining the needs of the health care system that, as a result, governments will need to balance expenses without upsetting national budgets. Therefore, the selection of a precise and affordable drug delivery technology is seen as the most practical solution for governments, health care professionals, and consumers. Transdermal drug delivery patches (TDDP) are one of the best economical technologies that are favored by pharmaceutical companies and physicians alike because it offers fewer complications when compared to other delivery technologies. TDDP provides increased efficiency, safety and convenience for the patient. The TDDP segment within the US and Global drug delivery markets were valued at 5.6 and 12.7 billion respectively in 2009. TDDP is forecasted to reach 31.5 billion in 2015. The present TDDP technology involves the fabrication of a patch that consists of a drug embedded in a polymeric matrix. The diffusion coefficient is determined from the slope of the cumulative drug release versus time. It is a trial and error method that is time and labor consuming. With all the advantages that TDDPs can offer, the methodology used to achieve the so-called optimum design has resulted in several incidents where the safety and design have been put to question in recent times (e.g. Fentanyl). A more logical screening methodology is needed. This work shows the use of a modified Duda Zielinsky equation (DZE). Experimental release curves from commercial are evaluated. The experimental and theoretical Diffusion Coefficient values are found to be within the limits specified in the patent literature. One interesting finding is that the accuracy of the DZE is closer to experimental values when the type of Molecular Shape and Radius are used. This work shows that the modified DZE could be used as an excellent screening tool to determine the optimal polymeric matrices that will yield the desired Diffusion Coefficient and thus effectively decreasing the amount of time and labor when developing TDDPs. Advisors/Committee Members: N. M. Ravindra, Michael Jaffe, Bozena B. Michniak.

Subjects/Keywords: Transdermal; Diffusion; Patches; Modelling; Materials Science and Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Falcone, R. P. (2015). New screening methodology for selection of polymeric materials for transdermal drug delivery devices. (Doctoral Dissertation). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/dissertations/116

Chicago Manual of Style (16^th Edition):

Falcone, Roberto P. “New screening methodology for selection of polymeric materials for transdermal drug delivery devices.” 2015. Doctoral Dissertation, New Jersey Institute of Technology. Accessed January 16, 2021. https://digitalcommons.njit.edu/dissertations/116.

MLA Handbook (7^th Edition):

Falcone, Roberto P. “New screening methodology for selection of polymeric materials for transdermal drug delivery devices.” 2015. Web. 16 Jan 2021.

Vancouver:

Falcone RP. New screening methodology for selection of polymeric materials for transdermal drug delivery devices. [Internet] [Doctoral dissertation]. New Jersey Institute of Technology; 2015. [cited 2021 Jan 16]. Available from: https://digitalcommons.njit.edu/dissertations/116.

Council of Science Editors:

Falcone RP. New screening methodology for selection of polymeric materials for transdermal drug delivery devices. [Doctoral Dissertation]. New Jersey Institute of Technology; 2015. Available from: https://digitalcommons.njit.edu/dissertations/116

New Jersey Institute of Technology

26. Wei, Ran. Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers.

Degree: MSin Pharmaceutical Engineering - (M.S.), Chemical, Biological and Pharmaceutical Engineering, 2011, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/theses/97

► This study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate… (more)

Subjects/Keywords: Iontophoresis; Enhancer; Transdermal; Transbuccal; Chemical Engineering; Pharmaceutics and Drug Design

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APA (6^th Edition):

Wei, R. (2011). Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers. (Thesis). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/theses/97

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wei, Ran. “Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers.” 2011. Thesis, New Jersey Institute of Technology. Accessed January 16, 2021. https://digitalcommons.njit.edu/theses/97.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wei, Ran. “Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers.” 2011. Web. 16 Jan 2021.

Vancouver:

Wei R. Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers. [Internet] [Thesis]. New Jersey Institute of Technology; 2011. [cited 2021 Jan 16]. Available from: https://digitalcommons.njit.edu/theses/97.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wei R. Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers. [Thesis]. New Jersey Institute of Technology; 2011. Available from: https://digitalcommons.njit.edu/theses/97

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

New Jersey Institute of Technology

27. Gendelberg, Natali R. Diffusivity of drug actives in transdermal drug delivery (TDD).

Degree: MSin Materials Science and Engineering - (M.S.), Committee for the Interdisciplinary Program in Materials Science and Engineering, 2016, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/theses/270

► Transdermal Drug Delivery (TDD) through skin patches has many advantages including the following: slow and continuous administration of the therapeutic over long periods of… (more)

Subjects/Keywords: Transdermal drug delivery (TDD); Skin permeability; Materials Science and Engineering

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APA (6^th Edition):

Gendelberg, N. R. (2016). Diffusivity of drug actives in transdermal drug delivery (TDD). (Thesis). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/theses/270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gendelberg, Natali R. “Diffusivity of drug actives in transdermal drug delivery (TDD).” 2016. Thesis, New Jersey Institute of Technology. Accessed January 16, 2021. https://digitalcommons.njit.edu/theses/270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gendelberg, Natali R. “Diffusivity of drug actives in transdermal drug delivery (TDD).” 2016. Web. 16 Jan 2021.

Vancouver:

Gendelberg NR. Diffusivity of drug actives in transdermal drug delivery (TDD). [Internet] [Thesis]. New Jersey Institute of Technology; 2016. [cited 2021 Jan 16]. Available from: https://digitalcommons.njit.edu/theses/270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gendelberg NR. Diffusivity of drug actives in transdermal drug delivery (TDD). [Thesis]. New Jersey Institute of Technology; 2016. Available from: https://digitalcommons.njit.edu/theses/270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

New Jersey Institute of Technology

28. Dong, Qian. A computational model for transdermal diffusion of lidocaine and tetracaine topical patches.

Degree: MSin Materials Science and Engineering - (M.S.), Committee for the Interdisciplinary Program in Materials Science and Engineering, 2016, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/theses/287

► In recent years, transdermal drug delivery patches (TDDP) have developed rapidly. This is because the TDD system has more advantages than traditional drug delivery… (more)

Subjects/Keywords: Transdermal drug delivery patches; Diffusion parameters; Materials Science and Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dong, Q. (2016). A computational model for transdermal diffusion of lidocaine and tetracaine topical patches. (Thesis). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/theses/287

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dong, Qian. “A computational model for transdermal diffusion of lidocaine and tetracaine topical patches.” 2016. Thesis, New Jersey Institute of Technology. Accessed January 16, 2021. https://digitalcommons.njit.edu/theses/287.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dong, Qian. “A computational model for transdermal diffusion of lidocaine and tetracaine topical patches.” 2016. Web. 16 Jan 2021.

Vancouver:

Dong Q. A computational model for transdermal diffusion of lidocaine and tetracaine topical patches. [Internet] [Thesis]. New Jersey Institute of Technology; 2016. [cited 2021 Jan 16]. Available from: https://digitalcommons.njit.edu/theses/287.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dong Q. A computational model for transdermal diffusion of lidocaine and tetracaine topical patches. [Thesis]. New Jersey Institute of Technology; 2016. Available from: https://digitalcommons.njit.edu/theses/287

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

AUT University

29. Chowdhury, Nargis Afroj. An Investigation Into Using Regenerated Cellulose-based Electro-conductive Composites for Actuation and Drug Delivery .

Degree: AUT University

URL: http://hdl.handle.net/10292/7696

► Under the influence of an electric field, ionic electro-active polymers generally bend or deswell, depending on the shape of the polymer matrices and its position… (more)

▼ Under the influence of an electric field, ionic electro-active polymers generally bend or deswell, depending on the shape of the polymer matrices and its position relative to the electrodes. In this study, we investigate the bending behaviour of regenerated cellulose-based ionic electro-active composites for the fabrication of soft actuators with improved actuation force and durability. This research also focuses on the externally induced (electrically and magnetically) matrices deswelling and other responses, which affect the release of drug from the matrices. For actuation studies, we prepared matrices by combining carbon nanofibers, conducting polymers, and ionic liquids (through blending, doping, or coating) into the regenerated cellulose. We observed that actuators coated by polypyrrole doped with anthraquinone-2-sulfonic acid sodium salt monohydrate showed improved electrical conductivity and durability compared to that of using perchlorate ion as the dopant. This is due to the preparation process and the effect of dopants that play an important role to improve the performance of the regenerated cellulose-based ionic electro-active actuators. In addition, we investigated the influence of electrode design (layer-by-layer structure) on the properties of the actuators. Further, in this study, we developed three types of matrices consisting of regenerated cellulose/functionalized carbon nanofibers, regenerated cellulose/functionalized carbon nanofibers/polypyrrole, and regenerated cellulose/γ-ferric oxide/polypyrrole. We investigated the effects of electric field strength and electrode polarity on the release rate of sulfosalicylic acid (drug) in an acetate buffer solution with pH 5.5 and temperature 37 ᵒC during a period of 5 h. Drug release rate from the matrices containing carbon nanofibers (additives) increased effectively with increasing applied electric field. The mechanism of drug release from drug-doped polypyrrole coated matrices includes expansion of conductive polymer chain and the electrostatic force between electron and drug. The novelty of the work is- the matrices can also work under magnetic field and consequently, one can be beneficial from a contactless actuation. In this study, we also investigated electrical conductivity, morphology, swelling behaviour of the composite matrices, electro-active composite-drug interaction, and in vitro drug release behaviour of the matrices. Further, a comparative study was performed on the rate of drug release from the matrices induced by electric and magnetic field. Advisors/Committee Members: Al-Jumaily, Ahmed (advisor), Robertson, John (advisor), Ramos, Maximiano V (advisor).

Subjects/Keywords: Drug delivery; Actuation; Transdermal impalnts

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chowdhury, N. A. (n.d.). An Investigation Into Using Regenerated Cellulose-based Electro-conductive Composites for Actuation and Drug Delivery . (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/7696

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chowdhury, Nargis Afroj. “An Investigation Into Using Regenerated Cellulose-based Electro-conductive Composites for Actuation and Drug Delivery .” Thesis, AUT University. Accessed January 16, 2021. http://hdl.handle.net/10292/7696.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chowdhury, Nargis Afroj. “An Investigation Into Using Regenerated Cellulose-based Electro-conductive Composites for Actuation and Drug Delivery .” Web. 16 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Chowdhury NA. An Investigation Into Using Regenerated Cellulose-based Electro-conductive Composites for Actuation and Drug Delivery . [Internet] [Thesis]. AUT University; [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10292/7696.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Chowdhury NA. An Investigation Into Using Regenerated Cellulose-based Electro-conductive Composites for Actuation and Drug Delivery . [Thesis]. AUT University; Available from: http://hdl.handle.net/10292/7696

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Debrecen

30. Hoang, Ha My. Infusion and Parenteral therapeutic systems .

Degree: DE – Gyógyszerésztudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/239579

► The purpose of my thesis is to analyze and focus on infusion and parenteral therapeutic system. It is composed of three main important chapters: Aseptic… (more)

Subjects/Keywords: Infusion; Transdermal; Implantable; Injectable

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hoang, H. M. (n.d.). Infusion and Parenteral therapeutic systems . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/239579

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hoang, Ha My. “Infusion and Parenteral therapeutic systems .” Thesis, University of Debrecen. Accessed January 16, 2021. http://hdl.handle.net/2437/239579.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hoang, Ha My. “Infusion and Parenteral therapeutic systems .” Web. 16 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Hoang HM. Infusion and Parenteral therapeutic systems . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2437/239579.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Hoang HM. Infusion and Parenteral therapeutic systems . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/239579

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

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Open Access Theses and Dissertations