You searched for subject:(Toxicity).
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University of Utah
1.
Snowhill, Elaine Wyne.
Effects of chronic amphetamine on central serotonergic and dopaminergic systems in rats of various ages.
Degree: PhD, Pharmacology & Toxicology;, 1983, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1327/rec/414 
► The central neurochemical effects of chronic low doses (0.5 or 5 mg/kg s.c., every 12 h for 2 wk) if d-amphetamine (AMPH) were studied in…
(more)
▼ The central neurochemical effects of chronic low doses (0.5 or 5 mg/kg s.c., every 12 h for 2 wk) if d-amphetamine (AMPH) were studied in rats of varying ages. Tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) activities in neostriata of male offspring of dams exposed to 5 mg/kg AMPH during gestation showed significant depressions at 3 weeks of age, while corresponding neurotransmitters were at control levels. In contrast, the striatal enzyme activities in the dams were normal, but significant depressions were observed in the levels of striatal 5-hydroxytryptamin (5-HT), 5-hydroxyindoleacetic acid 5-HIAA, dopamine (DA) 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA). All parameters returned to normal by 7 weeks. Neurochemical changes were minimal in juvenile and adult males subjected to the same AMPH dosing regimen. The hypothalamic concentrations of 5-HT, 5-HIAA, and DA in adult males were reduced at 16 h, but these parameters were unaffected in the juveniles. Recovery in the adults was complete by 3 wks post dosing. Not effects were seen with the lower dose of AMPH (0.5 mg/kg) in any age group. The chronic doses of AMPH used in this study are not as toxic to the central serotonergic or dopaminergic systems of the rat as higher doses that have previously been studied in acute and subacute dosing regimens. Under these condition, the age of the animal at the time of drug exposure did not significantly alter the severity of the toxicity that was observed. Further, our data suggest that that Neurotoxicity of AMPH is highly depend on dose and duration of exposure.
Subjects/Keywords: Toxicity
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APA (6th Edition):
Snowhill, E. W. (1983). Effects of chronic amphetamine on central serotonergic and dopaminergic systems in rats of various ages. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1327/rec/414
Chicago Manual of Style (16th Edition):
Snowhill, Elaine Wyne. “Effects of chronic amphetamine on central serotonergic and dopaminergic systems in rats of various ages.” 1983. Doctoral Dissertation, University of Utah. Accessed February 26, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1327/rec/414.
MLA Handbook (7th Edition):
Snowhill, Elaine Wyne. “Effects of chronic amphetamine on central serotonergic and dopaminergic systems in rats of various ages.” 1983. Web. 26 Feb 2021.
Vancouver:
Snowhill EW. Effects of chronic amphetamine on central serotonergic and dopaminergic systems in rats of various ages. [Internet] [Doctoral dissertation]. University of Utah; 1983. [cited 2021 Feb 26].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1327/rec/414.
Council of Science Editors:
Snowhill EW. Effects of chronic amphetamine on central serotonergic and dopaminergic systems in rats of various ages. [Doctoral Dissertation]. University of Utah; 1983. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1327/rec/414
University of Utah
2.
Johnson, Nathan H.
Adequacy of capillary lead specimens;.
Degree: MS;, Pathology;, 1995, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/840/rec/10
► In response to the increased demand for reliable alternatives to venous lead testing, the Centers for Disease Control has called for increased research into using…
(more)
▼ In response to the increased demand for reliable alternatives to venous lead testing, the Centers for Disease Control has called for increased research into using capillary methodologies. In the past, there have been problems with this procedure, primarily because of external lead contamination falsely elevating values. A three tiered approach was developed to assess the adequacy of capillary lead specimens. The first approach involved examination of a large database of capillary and venous samples for obvious differences. The second, approach involved analysis of elevated lead follow-ups for indications of gross contamination. The last approach involved experimentation to determine if hand washing eliminates gross contamination. Obvious differences were found between the venous and capillary databases. Gross contamination was rare, but the data suggest variables minor contamination. The analysis of elevated lead follow-ups demonstrated that gross contamination is sometimes present, but more likely to decrease in follow up results is due to day to day fluctuations in lead levels and decreases in minor contamination. Experimentation demonstrated that hand washings greatly reduces the amount of external lead contamination. Capillary lead testing should be considered a viable alternative to venous testing, provided that the patient and collector are meticulous in detail.
Subjects/Keywords: Toxicity
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APA (6th Edition):
Johnson, N. H. (1995). Adequacy of capillary lead specimens;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/840/rec/10
Chicago Manual of Style (16th Edition):
Johnson, Nathan H. “Adequacy of capillary lead specimens;.” 1995. Masters Thesis, University of Utah. Accessed February 26, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/840/rec/10.
MLA Handbook (7th Edition):
Johnson, Nathan H. “Adequacy of capillary lead specimens;.” 1995. Web. 26 Feb 2021.
Vancouver:
Johnson NH. Adequacy of capillary lead specimens;. [Internet] [Masters thesis]. University of Utah; 1995. [cited 2021 Feb 26].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/840/rec/10.
Council of Science Editors:
Johnson NH. Adequacy of capillary lead specimens;. [Masters Thesis]. University of Utah; 1995. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/840/rec/10
University of Manchester
3.
Clay, Robert.
Developmental Toxicity of Aluminium and Silver to
Drosophila melanogaster.
Degree: 2014, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:219559
► Aluminium (Al) and silver (Ag), through human activities, are present in the environment at concentrations sufficient to cause toxicity. The aim of this study was…
(more)
▼ Aluminium (Al) and silver (Ag), through human
activities, are present in the environment at concentrations
sufficient to cause
toxicity. The aim of this study was to
administer Al and Ag to the short lived model organism Drosophila
melanogaster, so that developmental
toxicity and potential
ameliorative interventions could be examined over a compressed
timescale relative to mammalian models.Aluminium was administered
to Drosophila in food as either the chloride salt or citrate
complex at concentrations of 1, 10 and 100 mM and various
developmental parameters were assessed. The lowest concentration to
delay pupation relative to the control was 10 mM but this depended
upon the food in which it was administered. Higher whole body
tissue levels of Al were seen following Al citrate administration
compared to AlCl3, but Al citrate was less toxic as this did not
did not impair larval viability at 100 mM; 100 mM AlCl3 resulted in
100% mortality. Eclosion success was significantly impaired with
either form of Al at 10 mM, but no difference was seen between the
forms of Al. When Drosophila were fed AlCl3 over their entire
lifespan, a small but significant reduction in the lifespan of male
flies was seen. No behavioural
toxicity could be demonstrated.
Existing studies have demonstrated significant tissue Al
concentrations and
toxicity whereas these have been minimal in this
study. It is suggested that these differences may have a genetic
component, with food composition exerting an influence also.Silver,
either as AgNO3 or Ag nanoparticles (AgNPs) was administered in
concentrations up to 500 micromolar and 10 mM, respectively. Either
form of Ag, at 50 micromolar was sufficient to significantly retard
pupation rate, although pupation or eclosion success was not
impaired until 100 micromolar. The concentration-response
relationship for AgNO3 was steep with pupation success dropping to
nearly zero by 300 micromolar; Drosophila in this study were far
more sensitive to AgNO3 than those in other reports. Animals
exposed to AgNPs were still able to pupate at 500 micromolar, but
these pupae were almost all non-viable when exposed to 400
micromolar AgNPs. At 1 mM and above, AgNPs, however, showed reduced
toxicity compared to lower concentrations. The reasons for this are
unclear. Both forms of Ag caused de-pigmentation in adults after
larval exposure that may be explainable by inhibition of polyphenol
oxidase enzymes by Ag (I) ions. The de-pigmentation was preventable
by pre-loading larvae with Cu. Ascorbate prevented the
de-pigmentation caused by AgNPs but not AgNO3 suggesting that AgNP
toxicity is due to Ag (I) ion release. Oxidation of AgNPs was found
to be greatly accelerated by Fe (III) and Cu (II) ions in the
presence of Cl- ions. Although some of the results here conflict
with the literature, developmental
toxicity has been observed here,
for both Al and Ag, and the variability across studies may provide
an opportunity for dissecting the mechanisms behind Al and Ag
toxicity through identification of the traits that confer…
Advisors/Committee Members: WHITE, KEITH KN, Mccrohan, Catherine, White, Keith.
Subjects/Keywords: silver toxicity; aluminium toxicity; aluminum toxicity; nanoparticles; AgNPs; drosophila; developmental toxicity
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APA (6th Edition):
Clay, R. (2014). Developmental Toxicity of Aluminium and Silver to
Drosophila melanogaster. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:219559
Chicago Manual of Style (16th Edition):
Clay, Robert. “Developmental Toxicity of Aluminium and Silver to
Drosophila melanogaster.” 2014. Doctoral Dissertation, University of Manchester. Accessed February 26, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:219559.
MLA Handbook (7th Edition):
Clay, Robert. “Developmental Toxicity of Aluminium and Silver to
Drosophila melanogaster.” 2014. Web. 26 Feb 2021.
Vancouver:
Clay R. Developmental Toxicity of Aluminium and Silver to
Drosophila melanogaster. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Feb 26].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:219559.
Council of Science Editors:
Clay R. Developmental Toxicity of Aluminium and Silver to
Drosophila melanogaster. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:219559
Oregon State University
4.
Almurshidi, Badria H.
Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp.
Degree: MS, Wood Science, 2015, Oregon State University
URL: http://hdl.handle.net/1957/56625
► Commercial methodologies for producing fungal pigments are of worldwide interest due to the desire to move away from synthetic dyes. Chlorociboria species and Scytalidium species…
(more)
▼ Commercial methodologies for producing fungal pigments are of worldwide interest due to the desire to move away from synthetic dyes. Chlorociboria species and Scytalidium species have been reported to produce sufficient yields of pigments for commercial production and have attracted special attention because of their use in spalted wood applications. However, there are few data about the
toxicity of these pigments on humans or the ecosystem. The main objective of this thesis was to examine fungal pigment mixture
toxicity and its effects on living organisms using a zebrafish embryo acute
toxicity bioassay. Pigment mixtures from wood agar cultures and liquid malt media were screened. There were significant adverse effects from both the DCM-extracted pigment and the liquid malt medium although there was variability in the
toxicity endpoints. The results from this study suggest that all dichloromethane (DCM) pigment extracts followed a dose/ response curve and caused higher mortality in higher concentrations after a short time of exposure except the DCM-red pigment extract which follow a non monotonic dose/response curve. The response from both DCM pigment extracts and liquid malt pigment depended on the solubility and bioavailability factors in the water. Overall, the results indicate that the pigments extracted from these fungi are likely toxic to humans. However, as no completely purified compounds were tested, it is possible that other secondary fungal metabolites and wood extractives that were also retrieved during the extraction process might also have played a role in the
toxicity.
Advisors/Committee Members: Robinson, Sara C. (advisor), Morrell, Jeff (committee member).
Subjects/Keywords: Toxicity of fungal pigments; Dichloromethane – Toxicity testing
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APA (6th Edition):
Almurshidi, B. H. (2015). Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/56625
Chicago Manual of Style (16th Edition):
Almurshidi, Badria H. “Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp.” 2015. Masters Thesis, Oregon State University. Accessed February 26, 2021.
http://hdl.handle.net/1957/56625.
MLA Handbook (7th Edition):
Almurshidi, Badria H. “Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp.” 2015. Web. 26 Feb 2021.
Vancouver:
Almurshidi BH. Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp. [Internet] [Masters thesis]. Oregon State University; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1957/56625.
Council of Science Editors:
Almurshidi BH. Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp. [Masters Thesis]. Oregon State University; 2015. Available from: http://hdl.handle.net/1957/56625
University of Georgia
5.
Baird, Suzanne Elizabeth.
Enantioselective toxicity, bioaccumulation, and biotransformation of fipronil in fathead minnows (Pimephales promelas).
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/25996
► Fipronil is a relatively new chiral, phenylpyrazole insecticide used to control both agricultural and household invertebrate pests. Fipronil is applied as a racemate, or equal…
(more)
▼ Fipronil is a relatively new chiral, phenylpyrazole insecticide used to control both agricultural and household invertebrate pests. Fipronil is applied as a racemate, or equal mixture, of its two enantiomers. Although a number of toxicity
studies have demonstrated enantioselective toxicity in aquatic invertebrates, data on enantioselective toxicity in fish is limited. We observed increased toxicity of the (+) enantiomer in larval fathead minnows exposed to the fipronil racemate and each
enantiomer seven days. Juvenile fathead minnows were exposed to fipronil-contaminated sediment. We found that fish rapidly bioaccumulated fipronil and transformed it to fipronil sulfone. Fish preferentially transformed the (-) enantiomer, resulting in an
increased proportion of the (+) enantiomer in fish tissues. This thesis illustrates the complex behavior of fipronil in fathead minnows and the need for additional research on the fate of fipronil in the aquatic environment.
Subjects/Keywords: Acute Toxicity; Subchronic Toxicity; Pesticides; Chiral; Enantioselective
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APA (6th Edition):
Baird, S. E. (2014). Enantioselective toxicity, bioaccumulation, and biotransformation of fipronil in fathead minnows (Pimephales promelas). (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25996
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Baird, Suzanne Elizabeth. “Enantioselective toxicity, bioaccumulation, and biotransformation of fipronil in fathead minnows (Pimephales promelas).” 2014. Thesis, University of Georgia. Accessed February 26, 2021.
http://hdl.handle.net/10724/25996.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Baird, Suzanne Elizabeth. “Enantioselective toxicity, bioaccumulation, and biotransformation of fipronil in fathead minnows (Pimephales promelas).” 2014. Web. 26 Feb 2021.
Vancouver:
Baird SE. Enantioselective toxicity, bioaccumulation, and biotransformation of fipronil in fathead minnows (Pimephales promelas). [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10724/25996.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Baird SE. Enantioselective toxicity, bioaccumulation, and biotransformation of fipronil in fathead minnows (Pimephales promelas). [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25996
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
6.
Chikuta, Sally.
Development of aluminum toxicity tolerance selection system for Sorghum(Sorghum Bicolor L.)Moench in Zambia
.
Degree: 2011, University of Zambia
URL: http://hdl.handle.net/123456789/572
► Sorghum (S. bicolor, L) is a major crop of the hotter and drier regions of the tropics and subtropics grown by resource poor farmers for…
(more)
▼ Sorghum (S. bicolor, L) is a major crop of the hotter and drier regions of the tropics and subtropics grown by resource poor farmers for their subsistence. It can also be cultivated in marginal lands and areas of high rainfall characterized by low pH soils high in aluminium (Al).The overall objective of this study was to characterize selected sorghum varieties for Al tolerance, while the specific objectives were, to determine performance of selected sorghum varieties grown in Al prone environments, to identify root characteristics associated with Al tolerance and to develop a selection criterion for Al tolerance in sorghum. Twenty sorghum genotypes (previously identified) were evaluated at three sites with high soil Al levels and in the laboratory. Genotypes, concentrations and interactions were significantly different (P≤0.001) for all the parameters studied in the laboratory which included root length, shoot length, number of lateral roots, shoot and root biomass. The correlation between the laboratory attributes and grain yield were highly significant. Direct effects ranged from 0.5 for lateral roots to 0.7 for shoot length. Indirect path effects towards grain yield by root length and root biomass were 0.6 and 0.5 respectively via shoot length. Significant differences (P≤0.05) were observed in the field study for seven of the nine parameters that were measured and/or derived. Interactions were significant for plant height and grain yield. The entries were significantly different for all the measured and derived parameters except for plant count, pest score and agronomic score. Significant differences were observed for location on days to 50% flowering, plant height, pest score, sundried head weight and grain yield. Associations between the measured and/or derived parameters and grain yield were significant. The direct path effects were low except for head weight which had a significant contribution of 1.4. Direct contributions on yield by other parameters were less than 0.1. Plant height, pest score and agronomic score had significant indirect effects of 0.7, 0.7 and 0.5 respectively via head weight. Results indicate that laboratory attributes can be used to predict high yielding sorghum genotypes suitable for low pH soil with Al toxicity. Selection of head weight and head harvest index would contribute effectively to high yielding sorghum genotypes in low pH soil with high Al. The superior genotypes recommended for Al tolerance are 11, 16, 17 and 20.
Subjects/Keywords: Alluminium toxicity;
Sorghum
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APA (6th Edition):
Chikuta, S. (2011). Development of aluminum toxicity tolerance selection system for Sorghum(Sorghum Bicolor L.)Moench in Zambia
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/572
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chikuta, Sally. “Development of aluminum toxicity tolerance selection system for Sorghum(Sorghum Bicolor L.)Moench in Zambia
.” 2011. Thesis, University of Zambia. Accessed February 26, 2021.
http://hdl.handle.net/123456789/572.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chikuta, Sally. “Development of aluminum toxicity tolerance selection system for Sorghum(Sorghum Bicolor L.)Moench in Zambia
.” 2011. Web. 26 Feb 2021.
Vancouver:
Chikuta S. Development of aluminum toxicity tolerance selection system for Sorghum(Sorghum Bicolor L.)Moench in Zambia
. [Internet] [Thesis]. University of Zambia; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/123456789/572.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chikuta S. Development of aluminum toxicity tolerance selection system for Sorghum(Sorghum Bicolor L.)Moench in Zambia
. [Thesis]. University of Zambia; 2011. Available from: http://hdl.handle.net/123456789/572
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Utah
7.
Alexander, Gary James.
Comparison of selected direct reading instruments used for sampling fumigants in the grain handling industry.
Degree: MPH;, Family & Preventive Medicine;, 2008, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1543/rec/239
► The Miran 1A Portable Gas Analyzer, the H-Nu Photoinization Analyzer, Gastec No. 134 Detector Tubes, and Drager No.5/a Detector Tubes have been evaluated in the…
(more)
▼ The Miran 1A Portable Gas Analyzer, the H-Nu Photoinization Analyzer, Gastec No. 134 Detector Tubes, and Drager No.5/a Detector Tubes have been evaluated in the laboratory for use as sampling instruments to detect carbon tetrachloride (CCl4) and carbon disulfide (CS2) in the grain handling industry. Because of the adverse health effects associated with excess exposure to CCl4 and CS2, and the potential for worker exposure to these contaminants in the grain industry, the evaluation of a simple, accurate, and rapid method to measure the concentrations of these compounds is needed. The Gastec CCl4 detector tubes and Drager CS2 detector tubes were not accurate or precise when evaluated in this study, and any data obtained from their use in the grain handling industry where CCl4 and CS2 are present are subject to considerable error. The H-Nu Photoinization Analyzer was calibrated for CS2, when it was used to measure the concentration of CS2. When it was used to measure the concentration of CS2 in air containing both CS2 and CCl4, the results were substantially higher than would be predicted from the calibration curve. The Miran 1A was calibrated for both CCl4 and CS2. The Mirian 1A was only direct reading instrument evaluated in this study that did not have potential CCl4 and CS2 interferences.
Subjects/Keywords: Public Health; Toxicity
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APA (6th Edition):
Alexander, G. J. (2008). Comparison of selected direct reading instruments used for sampling fumigants in the grain handling industry. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1543/rec/239
Chicago Manual of Style (16th Edition):
Alexander, Gary James. “Comparison of selected direct reading instruments used for sampling fumigants in the grain handling industry.” 2008. Masters Thesis, University of Utah. Accessed February 26, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1543/rec/239.
MLA Handbook (7th Edition):
Alexander, Gary James. “Comparison of selected direct reading instruments used for sampling fumigants in the grain handling industry.” 2008. Web. 26 Feb 2021.
Vancouver:
Alexander GJ. Comparison of selected direct reading instruments used for sampling fumigants in the grain handling industry. [Internet] [Masters thesis]. University of Utah; 2008. [cited 2021 Feb 26].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1543/rec/239.
Council of Science Editors:
Alexander GJ. Comparison of selected direct reading instruments used for sampling fumigants in the grain handling industry. [Masters Thesis]. University of Utah; 2008. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1543/rec/239
Georgia Tech
8.
Nicosia, John Michael.
Crosslink-dependent pulmonary toxicity of pNIPAM-AAc microgels.
Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2019, Georgia Tech
URL: http://hdl.handle.net/1853/62687
► Microgels, also referred to as nanogels, are hydrophilic polymer networks synthesized into micro- or nano-sized hydrogel particles. Due to their relative ease of synthesis and…
(more)
▼ Microgels, also referred to as nanogels, are hydrophilic polymer networks synthesized into micro- or nano-sized hydrogel particles. Due to their relative ease of synthesis and highly tunable properties, they have been explored extensively for a range of biomedical applications, including therapeutic delivery, imaging, and biosensors. Yet despite decades of research, only a handful of microgel-based technologies have reached clinical trials. Primary barriers to clinical translation of microgels include rapid clearance from circulation and
toxicity or off-target effects. While there have been many advancements in microgel research, there still exists a lack of understanding of the factors that drive microgel behavior in vivo
To address this gap in knowledge, this work uses poly(N-isopropylacrylamide)-co-acrylic acid (pNIPAM-AAc) microgels as a case study in how microgel crosslink density affects mechanical properties of microgels in physiologic settings, and correspondingly influences their behavior in vivo. The central hypothesis of this work is that increased crosslinking leads to shorter blood circulation time of microgels, and enhanced margination to the walls of blood vessels. Microgel characteristics were evaluated with a combination of single microgel atomic force microscopy (AFM) nanoindentation techniques along with light scattering and rheological analysis of microgel suspensions. A variety of microfluidic systems were used to investigate microgel behavior in whole blood, while in vivo testing was carried out to determine biodistribution, clearance time, and potential
toxicity. Increased crosslinking had minimal effect on clearance time and margination of pNIPAM-AAc microgels, though crosslinking was associated with longer retention time in the kidneys. During biodistribution studies, it was observed that some mice who received crosslinked microgels showed signs of significant
toxicity. Follow-up in vitro and in vivo studies revealed that crosslinked microgels have a greater tendency to form large aggregates in blood that can occlude lung microvasculature, though this does not lead to an overall inflammatory response. Instead, it is likely that crosslinked microgels occasionally form especially large aggregates that result in rare catastrophic events similar to a pulmonary embolism. Further exploration of this phenomenon revealed that aggregate formation is driven by hydrophobic interactions and exacerbated by the binding of plasma proteins such as albumin. Rational design of microgel-based therapies should utilize stably hydrophilic polymers to minimize protein binding and reduce the risk of aggregate formation in blood.
Advisors/Committee Members: Lam, Wilbur A. (advisor), Barker, Thomas H. (advisor), Brown, Ashley C. (committee member), Santangelo, Philip (committee member), Fernandez-Nieves, Alberto (committee member), Kwong, Gabriel (committee member).
Subjects/Keywords: Microparticles; Toxicity; Nanotechnology
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APA (6th Edition):
Nicosia, J. M. (2019). Crosslink-dependent pulmonary toxicity of pNIPAM-AAc microgels. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/62687
Chicago Manual of Style (16th Edition):
Nicosia, John Michael. “Crosslink-dependent pulmonary toxicity of pNIPAM-AAc microgels.” 2019. Doctoral Dissertation, Georgia Tech. Accessed February 26, 2021.
http://hdl.handle.net/1853/62687.
MLA Handbook (7th Edition):
Nicosia, John Michael. “Crosslink-dependent pulmonary toxicity of pNIPAM-AAc microgels.” 2019. Web. 26 Feb 2021.
Vancouver:
Nicosia JM. Crosslink-dependent pulmonary toxicity of pNIPAM-AAc microgels. [Internet] [Doctoral dissertation]. Georgia Tech; 2019. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1853/62687.
Council of Science Editors:
Nicosia JM. Crosslink-dependent pulmonary toxicity of pNIPAM-AAc microgels. [Doctoral Dissertation]. Georgia Tech; 2019. Available from: http://hdl.handle.net/1853/62687
9.
Anitha Pius P.
Fluoride toxicity: contribution of water and food a study
with reference to certain fluorotic and non-fluorotic areas of
Tamilnadu.
Degree: Chemistry, 1993, INFLIBNET
URL: http://shodhganga.inflibnet.ac.in/handle/10603/16239
► This thesis embodies the results of studies on quotFluoride toxicity Contribution of water and food, with reference to certain fluorotic and non-fluorotic areas of Tamilnaduquot.…
(more)
▼ This thesis embodies the results of studies on
quotFluoride toxicity Contribution of water and food, with
reference to certain fluorotic and non-fluorotic areas of
Tamilnaduquot. The Thesis is divided into four chapters. In the
first chapter, a general introduction about the various
manifestations of fluoride toxicity is given. Concepts of ionic,
non-ionic and total fluoride, contribution of water and food to
total intake of fluoride and various other factors influencing the
fluoride toxicity are discussed. The problem of fluorosis in
various parts of the world and also in several states of India has
been reviewed. The need and objectives of the present study are
clearly spelt at the end of this chapter. The second chapter deals
with the methodology adopted in this study in detail. The criteria
for the selection of controls and fluorotic areas and also for the
selection of families in each area are given. Methods of analysis
of drinking water for fluoride, hardness, alkalinity, pH,
chlorides, sulphates, calcium, magnesium, sodium, potassium,
molybdenum, copper, zinc, manganese and strontium are presented in
detail. Analysis of fluorides in chief staple food grains grown in
the areas under study, by the fluoride electrode method is
described. Details of analysis of trace ions by Atomic Absorption
Spectroscopy (AAS) and Inductively Coupled Plasma Emission
Spectroscopy (ICPES) are presented. The methodology developed in
the present study for assessment of contribution of water and food
separately to the total intake of fluoride, and various other ions
listed above is also dealt with at the end of this chapter. newline
Experimental results, analysis of the data, and the related
discussions comprise the third chapter of this thesis. The problem
of fluoride toxicity is analysed in the light of the results of
water analysis for fluoride, various chemical parameters and other
constituents and also based on the results of the analysis of the
diet consumed by the people, for fluoride and all other
inorganic
References included
Advisors/Committee Members: Appa Rao B V.
Subjects/Keywords: Chemistry; Fluoride Toxicity
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APA (6th Edition):
P, A. P. (1993). Fluoride toxicity: contribution of water and food a study
with reference to certain fluorotic and non-fluorotic areas of
Tamilnadu. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/16239
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
P, Anitha Pius. “Fluoride toxicity: contribution of water and food a study
with reference to certain fluorotic and non-fluorotic areas of
Tamilnadu.” 1993. Thesis, INFLIBNET. Accessed February 26, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/16239.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
P, Anitha Pius. “Fluoride toxicity: contribution of water and food a study
with reference to certain fluorotic and non-fluorotic areas of
Tamilnadu.” 1993. Web. 26 Feb 2021.
Vancouver:
P AP. Fluoride toxicity: contribution of water and food a study
with reference to certain fluorotic and non-fluorotic areas of
Tamilnadu. [Internet] [Thesis]. INFLIBNET; 1993. [cited 2021 Feb 26].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16239.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
P AP. Fluoride toxicity: contribution of water and food a study
with reference to certain fluorotic and non-fluorotic areas of
Tamilnadu. [Thesis]. INFLIBNET; 1993. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16239
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Saskatchewan
10.
Kallarakavumkal Thomas, Jith.
Effects of dietary and in ovo selenomethionine exposure in zebrafish.
Degree: 2014, University of Saskatchewan
URL: http://hdl.handle.net/10388/ETD-2014-09-1744
► Selenium (Se) is an essential trace element to most living organisms, however when compared to other ingested essential trace elements Se has the lowest margin…
(more)
▼ Selenium (Se) is an essential trace element to most living organisms, however when compared to other ingested essential trace elements Se has the lowest margin of safety between essential and toxic concentrations. Oviparous vertebrates, especially fishes, are highly susceptible to dietary Se
toxicity. Greater incidences of deformities and/or mortalities have been observed in F1 generation larval fishes whose parents were exposed to excess dietary Se in the form of selenomethionine (SeMet), however little information is available on effects of chronic dietary SeMet exposure to adult fish and persistent effects of in ovo SeMet exposure to F1 generation fish. This thesis investigated effects of chronic dietary exposure of excess Se in the form of SeMet on swimming performance (Ucrit), oxygen consumption (MO2), stored energy (triglycerides and glycogen), and the physiological stress response (cortisol production) in adult zebrafish (Danio rerio), as well as immediate (incidence of deformities and mortality) and persistent (e.g. changes in Ucrit, MO2, bioenergetics, the physiological stress response and reproduction) effects of in ovo exposure to SeMet in F1 generation zebrafish. In addition, the study investigated potential underlying mechanisms of SeMet-induced developmental toxicities in early life stages of zebrafish using embryo microinjection.
Two separate dietary SeMet exposure studies in adult zebrafish and two in ovo SeMet maternal transfer studies in F1 generation zebrafish were conducted. The first dietary or in ovo exposure study explored effects of excess SeMet exposure on adult zebrafish or the entire life cycle of F1 generation zebrafish. The second study investigated mechanisms of observed SeMet-induced effects on adult or F1 generation zebrafish. In the first feeding study, a significant reduction in Ucrit and greater accumulation of stored energy were observed in the excess dietary SeMet exposed groups when compared to the Se-sufficient dietary control group. The second feeding study showed a greater metabolic rate, and impaired aerobic energy metabolism and triglyceride homeostasis in adult fish fed excess dietary SeMet, which was associated with a reduction in swimming performance and accumulation of triglycerides. Embryos collected from adult zebrafish in both dietary SeMet exposure studies were used to investigate effects of in ovo SeMet exposure on the entire life cycle of F1 generation fish. The first study showed a greater incidence of mortality, an increasing trend for deformities in F1 generation larval zebrafish, and reduced Ucrit in F1 generation adult fish exposed to excess SeMet via in ovo maternal transfer. However, concentrations of stored energy, cortisol and reproduction were unaltered. The second study found that impaired aerobic performance might have been responsible for the reduction in Ucrit of F1 generation adult zebrafish exposed to excess SeMet. Since there is a high variability in Se deposition among eggs via natural maternal transfer, SeMet embryo microinjection…
Advisors/Committee Members: Janz, David M., Blakley, Barry, Krone, Pat, Niyogi, Som, Drew, Murray.
Subjects/Keywords: Selenomethionine
Zebrafish
Toxicity
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Manager
APA (6th Edition):
Kallarakavumkal Thomas, J. (2014). Effects of dietary and in ovo selenomethionine exposure in zebrafish. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2014-09-1744
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kallarakavumkal Thomas, Jith. “Effects of dietary and in ovo selenomethionine exposure in zebrafish.” 2014. Thesis, University of Saskatchewan. Accessed February 26, 2021.
http://hdl.handle.net/10388/ETD-2014-09-1744.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kallarakavumkal Thomas, Jith. “Effects of dietary and in ovo selenomethionine exposure in zebrafish.” 2014. Web. 26 Feb 2021.
Vancouver:
Kallarakavumkal Thomas J. Effects of dietary and in ovo selenomethionine exposure in zebrafish. [Internet] [Thesis]. University of Saskatchewan; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10388/ETD-2014-09-1744.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kallarakavumkal Thomas J. Effects of dietary and in ovo selenomethionine exposure in zebrafish. [Thesis]. University of Saskatchewan; 2014. Available from: http://hdl.handle.net/10388/ETD-2014-09-1744
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Saskatchewan
11.
Pettem, Connor Maurice 1991-.
Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes.
Degree: 2018, University of Saskatchewan
URL: http://hdl.handle.net/10388/8475
► Selenium (Se) is an essential micronutrient involved in important metabolic functions for all vertebrate species. As Se is reported to have a narrow margin between…
(more)
▼ Selenium (Se) is an essential micronutrient involved in important metabolic functions for all vertebrate species. As Se is reported to have a narrow margin between essentiality and
toxicity, there is growing concern surrounding the adverse effects of elevated Se exposure caused by anthropogenic activities. Recent studies have reported that elevated dietary exposure of fish to selenomethionine (Se-Met) can alter aerobic metabolic capacity, energetics and swimming performance. My thesis aimed to further investigate mechanisms of sublethal Se-Met
toxicity, particularly potential underlying cardiovascular implications of chronic exposure to environmentally relevant concentrations of dietary Se-Met in adult zebrafish (Danio rerio) and juvenile (yearling) rainbow trout (Oncorhynchus mykiss). In my first experiment, adult zebrafish were fed either control food (1.1 μg Se/g dry mass [d.m.]) or Se-Met spiked food (10.3 or 28.8 μg Se/g d.m.) for 90 d at 5% body weight per day. In the second experiment, juvenile rainbow trout were fed either control food (1.3 μg Se/g d.m.) or Se-Met spiked food (6.4, 15.8 or 47.8 μg Se/g d.m.) for 60 d at 5% body weight per day. Following exposure, ultrahigh resolution B-mode and Doppler ultrasound was used to characterize cardiac function. Chronic dietary exposure to elevated Se-Met had opposing results in zebrafish when compared to the rainbow trout. Zebrafish exposed to the highest dietary concentrations of Se-Met (28.8 μg Se/g d.m.) had significantly reduced ventricular contractile rate, stroke volume, and cardiac output, while Se-Met exposed rainbow trout had significantly greater stroke volume, ejection fraction, and cardiac output.
Following ultasonography, energy stores were measured via whole body (zebrafish) and liver, heart and muscle (rainbow trout) glycogen and triglyceride concentrations. Zebrafish in the highest exposure group were observed to have greater whole body glycogen concentrations when compared to the control group, while rainbow trout exposed to Se-Met concentrations greater than 15.8 μg Se/g showed significant increases in both glycogen and triglycerides in liver relative to the control group. In addition, rainbow trout in the highest exposure group had significantly reduced capability of managing blood glucose levels as was evident after 48hrs in a glucose tolerance test.
Exposure to Se-Met significantly decreased mRNA expression of a key cardiac remodelling enzyme, matrix metalloproteinase 2 (MMP2), in adult zebrafish heart, however significantly increased it (MMP9) in rainbow trout heart. Selenomethionine significantly increased echodensity at the junction between atrium and ventricle in zebrafish, and these results combined with increased MMP2 expression are consistent with cardiac remodelling and fibrosis. However, rainbow trout did not show any fibrosis and also had a significant decrease in SERPINH mRNA abundance, a molecular chaperone essential for the post-translational folding of fibril-forming collagens. This, taken together with the increase in MMP9,…
Advisors/Committee Members: Janz, David M, Weber, Lynn P, Janz, David M, Weber, Lynn P, Blakley, Barry, Krone, Patrick, Tierney, Keith.
Subjects/Keywords: cardiometabolic; toxicity; selenium
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APA ·
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CSE |
Export
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APA (6th Edition):
Pettem, C. M. 1. (2018). Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/8475
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pettem, Connor Maurice 1991-. “Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes.” 2018. Thesis, University of Saskatchewan. Accessed February 26, 2021.
http://hdl.handle.net/10388/8475.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pettem, Connor Maurice 1991-. “Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes.” 2018. Web. 26 Feb 2021.
Vancouver:
Pettem CM1. Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes. [Internet] [Thesis]. University of Saskatchewan; 2018. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10388/8475.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pettem CM1. Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes. [Thesis]. University of Saskatchewan; 2018. Available from: http://hdl.handle.net/10388/8475
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Saskatchewan
12.
Maloney, Erin M.
CUMULATIVE TOXICITIES OF NEONICOTINOID INSECTICIDES AND THEIR MIXTURES TO SENSITIVE FRESHWATER INSECTS.
Degree: 2020, University of Saskatchewan
URL: http://hdl.handle.net/10388/12856
► Neonicotinoids are neurotoxic insecticides that are commonly applied to combat agricultural pests. Due to widespread application and select physicochemical characteristics, mixtures of different neonicotinoids are…
(more)
▼ Neonicotinoids are neurotoxic insecticides that are commonly applied to combat agricultural pests. Due to widespread application and select physicochemical characteristics, mixtures of different neonicotinoids are frequently detected in freshwater environments. This is of potential concern because these freshwater habitats are populated with ecologically important benthic macroinvertebrates (e.g. Chironomidae), which are markedly sensitive to neonicotinoid compounds. Despite the likelihood of continuous and/or repeated exposure, previous studies have primarily evaluated the individual toxicities of these neurotoxic compounds. Yet, little is known about how mixtures affect sensitive aquatic insects under real world exposure scenarios. Thus, the objectives of this research were to (1) evaluate acute and chronic toxicities of three commonly used neonicotinoids (imidacloprid (IMI), clothianidin (CLO), and thiamethoxam (TMX)) and their mixtures to Chironomidae using Chironomus dilutus as a representative test species, (2) validate single compound and neonicotinoid mixture
toxicity predictions to Chironomidae populations under field settings, and (3) identify mechanisms behind species-, life stage-, and compound-specific differences in neonicotinoid
toxicity for these sensitive aquatic insects.
To address the first objective of this research, acute (96 h, endpoint = lethality) and chronic (28 d, endpoint = cessation of emergence) laboratory-based
toxicity tests were carried out, characterizing the toxicities of IMI, CLO, TMX and their binary and ternary mixtures to larval C. dilutus. Using the MIXTOX approach (a statistical technique based on fitting mixture
toxicity data to pre-defined mixture models), the nature and magnitude of cumulative
toxicity was classified for each neonicotinoid mixture. Several mixtures were found to display cumulative
toxicity that significantly deviated from direct, concentration-based additivity. Under acute exposure settings, all IMI-containing mixtures (IMI-CLO, IMI-TMX, and IMI-CLO-TMX) exhibited synergism when the concentrations of IMI in the solution were dominant (up to 7 %, 28 %, and 6 % decreases in survival, respectively), and some mixtures (IMI-CLO and IMI-TMX) displayed antagonism when the other mixture constituent was dominant (up to 19 % and 30 % increases in survival, respectively). Under chronic exposure settings all binary mixtures demonstrated dose-ratio dependent deviation from direct additivity (concentration addition), displaying synergism at high concentrations of CLO (IMI-CLO: 13 % decrease in emergence) or TMX (CLO-TMX and IMI-TMX: 2 % and 4 % decreases in emergence, respectively) and antagonism at high concentrations of IMI (IMI-CLO and IMI-TMX: 5 %, and 2 % increases in emergence, respectively). Under chronic exposures, the ternary mixture (IMI-CLO-TMX) elicited an overall antagonistic effect (2 % increase in emergence). Thus, laboratory-derived bioassays indicated that under both acute and chronic exposure settings, neonicotinoid mixtures had the potential to display…
Advisors/Committee Members: Liber, Karsten, Morrissey, Christy A, Wickstrom, Mark, Simko, Elemir, Hecker, Markus, Niyogi, Som.
Subjects/Keywords: Neonicotinoid; mixture toxicity
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APA ·
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Export
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APA (6th Edition):
Maloney, E. M. (2020). CUMULATIVE TOXICITIES OF NEONICOTINOID INSECTICIDES AND THEIR MIXTURES TO SENSITIVE FRESHWATER INSECTS. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12856
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Maloney, Erin M. “CUMULATIVE TOXICITIES OF NEONICOTINOID INSECTICIDES AND THEIR MIXTURES TO SENSITIVE FRESHWATER INSECTS.” 2020. Thesis, University of Saskatchewan. Accessed February 26, 2021.
http://hdl.handle.net/10388/12856.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Maloney, Erin M. “CUMULATIVE TOXICITIES OF NEONICOTINOID INSECTICIDES AND THEIR MIXTURES TO SENSITIVE FRESHWATER INSECTS.” 2020. Web. 26 Feb 2021.
Vancouver:
Maloney EM. CUMULATIVE TOXICITIES OF NEONICOTINOID INSECTICIDES AND THEIR MIXTURES TO SENSITIVE FRESHWATER INSECTS. [Internet] [Thesis]. University of Saskatchewan; 2020. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10388/12856.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Maloney EM. CUMULATIVE TOXICITIES OF NEONICOTINOID INSECTICIDES AND THEIR MIXTURES TO SENSITIVE FRESHWATER INSECTS. [Thesis]. University of Saskatchewan; 2020. Available from: http://hdl.handle.net/10388/12856
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Univerzitet u Beogradu
13.
Stanković, Vesna V., 1964-.
Prediktivni značaj individualnih i kliničkih
karakteristika osoba sa adenokarcinomom prostate na rizik za
nastanak akutne i kasne toksičnosti nakon zračne
terapije.
Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:14102/bdef:Content/get
► Radiologija - Radiaciona onkologija / Radiology - Radiation Oncology
Uvod: Efekat zračenja na zdrava tkiva i organe može se javiti u toku zračne terapije i…
(more)
▼ Radiologija - Radiaciona onkologija / Radiology -
Radiation Oncology
Uvod: Efekat zračenja na zdrava tkiva i organe može
se javiti u toku zračne terapije i neposredno nakon završetka
zračne terapije kada govorimo o akutnoj toksičnosti ili se može
javiti od 6 meseci do 20 god nakon završene zračne terapije, kada
govorimo o kasnoj toksičnosti. Što je veći volumen zdravog tkiva
koji prima visoke doze zračenja, to je i učestalost težih
komplikacija veća tzv efekat volumena zračenja. Rezultati studija
koji su se bavili ovom problematikom pokazali su da je osim efekta
volumena zračenja na učestalost komplikacija zračne terapije mogli
da utiču i individualni i klinički parametri kao što su pušenje,
primena androgene deprivacije, prisustvo komorbiditeta (hemoroidi,
diabetes mellitus, arterijska hipertenzija), primena
antikoagulantne i antiagregacione terapije kao i prethodne
abdominalne operacije. U poslednjih 10 tak godina je ispitano oko
60 gena kao mogućih faktora koji utiču na ispoljavanje individualne
osetljivosti zdravih organa na zračnu terapiju, ali se nijedan od
njih još uvek nije izdvojio kao gen odgovoran za povećanu
radiosenzitivnost ili radiorezistentnost zdravih tkiva Ciljevi
našeg istraživanja su bili određivanje incidence akutne i kasne
gastrointestinalne i genitourinarne toksičnosti u pacijenata sa
karcinomom prostate u lokalizovanom stadijumu, lečenih 3D
konformalnom zračnom terapijom i određivanje mogućeg uticaja
dozimetrijskih, individualnih I kliničkih parametara na
ispoljavanje simptoma toksičnosti. Materijal i metode: Od septembra
2009 do septembra 2013 godine, 225 pacijenata sa histološki
potvrđenim adenokarcinomom prostate u lokalizovanom stadijumu
bolesti su lečeni 3D konformalnom zračnom terapijom, u Institutu za
onkologiju I radiologiju Srbije. 94 od 225 pacijenata je ispunilo
kriterijume za uključivanje u ovo istraživanje. Svi su bili u
lokalizovanom stadijumu bolesti sa procenjenim rizikom za
infiltraciju lgl≤15%, prema Roach-ovoj formuli, KI>80%. Svi
pacijenti su primili 72Gy u 36 seansi, konformalnom tehnikom,
konvencionalnom šemom frakcionisanja. Akutna I kasna
gastrointestinalna I genitourinarna toksičnost je gradirana prema
EORTC/RTOG skoring kriterijumima...
Advisors/Committee Members: Nikitović, Marina, 1959-.
Subjects/Keywords: prostate cancer; conformal radiotherapy; acute
toxicity; late toxicity; gastrointestinal toxicity; genitourinary
toxicity; genetic markers
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
Stanković, Vesna V., 1. (2016). Prediktivni značaj individualnih i kliničkih
karakteristika osoba sa adenokarcinomom prostate na rizik za
nastanak akutne i kasne toksičnosti nakon zračne
terapije. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14102/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stanković, Vesna V., 1964-. “Prediktivni značaj individualnih i kliničkih
karakteristika osoba sa adenokarcinomom prostate na rizik za
nastanak akutne i kasne toksičnosti nakon zračne
terapije.” 2016. Thesis, Univerzitet u Beogradu. Accessed February 26, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:14102/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stanković, Vesna V., 1964-. “Prediktivni značaj individualnih i kliničkih
karakteristika osoba sa adenokarcinomom prostate na rizik za
nastanak akutne i kasne toksičnosti nakon zračne
terapije.” 2016. Web. 26 Feb 2021.
Vancouver:
Stanković, Vesna V. 1. Prediktivni značaj individualnih i kliničkih
karakteristika osoba sa adenokarcinomom prostate na rizik za
nastanak akutne i kasne toksičnosti nakon zračne
terapije. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Feb 26].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14102/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stanković, Vesna V. 1. Prediktivni značaj individualnih i kliničkih
karakteristika osoba sa adenokarcinomom prostate na rizik za
nastanak akutne i kasne toksičnosti nakon zračne
terapije. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14102/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Plymouth
14.
Mohammadbakir, Sahib.
Impacts of waterborne copper and silver on the early life stage (ELS) of zebrafish (Danio rerio) : physiological, biochemical and molecular responses.
Degree: PhD, 2016, University of Plymouth
URL: http://hdl.handle.net/10026.1/6550
► Toxic metals are major pollutants of the aquatic environment and are able to cause survival impairment of the early life stage of the aquatic organisms.…
(more)
▼ Toxic metals are major pollutants of the aquatic environment and are able to cause survival impairment of the early life stage of the aquatic organisms. They can affect the osmoregulatory system and electrolyte balance in fishes as well as the expression of genes which are essential in the formation and development of the organs at the early embryonic stages of development. There are a lack of studies concerning the toxic effects of waterborne copper and silver on the osmoregulation, electrolytes balance and expression the genes which are responsible for the formation and development of heart and metal binding proteins in the early life stage of zebrafish. The current study aimed to assess the toxic effects of waterborne concentrations of copper as an essential trace element, and silver as a non-essential trace element, on biochemical processes and the molecular biology of the early life stages (ELS) of zebrafish. The first experiment of the current study (Chapter 3) aimed: 1. to determine the time of nkx2.5 gene expression, a gene involved in cardiac development, relative to the time of embryonic development. 2. To assess the toxic concentration of the copper and most vulnerable and sensitive stage of the embryos < 1 hour post fertilization (hpf) exposed to the copper via water route. The result of the experiment showed that the expression of the nkx2.5 gene reached a maximum at 16 hpf. The first 10 hpf of the embryonic development was the most vulnerable and critical stage of the developing embryos, and characterized by increased mortality as copper concentration increased, and delayed and decreased hatching success. Exposure of embryos for 72 hpf to a concentration of 500 µg L-1 Cu increased heart rate, whereas the exposure of the embryos at the blastula stage only, showed decreases in heart rate. The third part of the experiment evaluated the protective effect of calcium as a major cation of water hardness on Cu toxicity. Embryos age < 2 hpf were exposed to copper (0, 100, 250, and 500 µg L-1), with or without added calcium (40 mg L-1). An increase in embryonic Cu accumulation was observed in live and dead embryos exposed to Cu, with and without added calcium. Calcium concentration increased with embryonic copper tissue concentration in dead embryos. Na+ and K+ concentrations were higher in live embryos compared to dead embryos, and a 4 fold decrease in Na+K+-ATPase activity was seen in live embryos exposed to copper compared to controls. There was no effect of copper on total glutathione. Expression of nkx2.5 as one of the essential genes for the formation and development of the heart increased significantly; approximately 10 fold in the presence of Cu+Ca in comparison to the unexposed control or Cu exposure alone. Whereas expression of mt2 increased significantly 6 fold compared to the control during Cu exposure without added Ca2+. The second experiment (Chapter 4) aimed to investigate the effect of the dissolved Ag+ as AgNO3 on the survival of the early life stage of zebrafish. Embryos < 2 hpf were exposed to…
Subjects/Keywords: 597; Metal Toxicity
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APA (6th Edition):
Mohammadbakir, S. (2016). Impacts of waterborne copper and silver on the early life stage (ELS) of zebrafish (Danio rerio) : physiological, biochemical and molecular responses. (Doctoral Dissertation). University of Plymouth. Retrieved from http://hdl.handle.net/10026.1/6550
Chicago Manual of Style (16th Edition):
Mohammadbakir, Sahib. “Impacts of waterborne copper and silver on the early life stage (ELS) of zebrafish (Danio rerio) : physiological, biochemical and molecular responses.” 2016. Doctoral Dissertation, University of Plymouth. Accessed February 26, 2021.
http://hdl.handle.net/10026.1/6550.
MLA Handbook (7th Edition):
Mohammadbakir, Sahib. “Impacts of waterborne copper and silver on the early life stage (ELS) of zebrafish (Danio rerio) : physiological, biochemical and molecular responses.” 2016. Web. 26 Feb 2021.
Vancouver:
Mohammadbakir S. Impacts of waterborne copper and silver on the early life stage (ELS) of zebrafish (Danio rerio) : physiological, biochemical and molecular responses. [Internet] [Doctoral dissertation]. University of Plymouth; 2016. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10026.1/6550.
Council of Science Editors:
Mohammadbakir S. Impacts of waterborne copper and silver on the early life stage (ELS) of zebrafish (Danio rerio) : physiological, biochemical and molecular responses. [Doctoral Dissertation]. University of Plymouth; 2016. Available from: http://hdl.handle.net/10026.1/6550
University of Manchester
15.
Clay, Robert.
Developmental toxicity of aluminium and silver to Drosophila melanogaster.
Degree: PhD, 2014, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/developmental-toxicity-of-aluminium-and-silver-to-drosophila-melanogaster(f9d8e295-8ce2-4627-bb38-1dae0998b57f).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756789
► Aluminium (Al) and silver (Ag), through human activities, are present in the environment at concentrations sufficient to cause toxicity. The aim of this study was…
(more)
▼ Aluminium (Al) and silver (Ag), through human activities, are present in the environment at concentrations sufficient to cause toxicity. The aim of this study was to administer Al and Ag to the short lived model organism Drosophila melanogaster, so that developmental toxicity and potential ameliorative interventions could be examined over a compressed timescale relative to mammalian models. Aluminium was administered to Drosophila in food as either the chloride salt or citrate complex at concentrations of 1, 10 and 100 mM and various developmental parameters were assessed. The lowest concentration to delay pupation relative to the control was 10 mM but this depended upon the food in which it was administered. Higher whole body tissue levels of Al were seen following Al citrate administration compared to AlCl3, but Al citrate was less toxic as this did not did not impair larval viability at 100 mM; 100 mM AlCl3 resulted in 100% mortality. Eclosion success was significantly impaired with either form of Al at 10 mM, but no difference was seen between the forms of Al. When Drosophila were fed AlCl3 over their entire lifespan, a small but significant reduction in the lifespan of male flies was seen. No behavioural toxicity could be demonstrated. Existing studies have demonstrated significant tissue Al concentrations and toxicity whereas these have been minimal in this study. It is suggested that these differences may have a genetic component, with food composition exerting an influence also. Silver, either as AgNO3 or Ag nanoparticles (AgNPs) was administered in concentrations up to 500 micromolar and 10 mM, respectively. Either form of Ag, at 50 micromolar was sufficient to significantly retard pupation rate, although pupation or eclosion success was not impaired until 100 micromolar. The concentration-response relationship for AgNO3 was steep with pupation success dropping to nearly zero by 300 micromolar; Drosophila in this study were far more sensitive to AgNO3 than those in other reports. Animals exposed to AgNPs were still able to pupate at 500 micromolar, but these pupae were almost all non-viable when exposed to 400 micromolar AgNPs. At 1 mM and above, AgNPs, however, showed reduced toxicity compared to lower concentrations. The reasons for this are unclear. Both forms of Ag caused de-pigmentation in adults after larval exposure that may be explainable by inhibition of polyphenol oxidase enzymes by Ag (I) ions. The de-pigmentation was preventable by pre-loading larvae with Cu. Ascorbate prevented the de-pigmentation caused by AgNPs but not AgNO3 suggesting that AgNP toxicity is due to Ag (I) ion release. Oxidation of AgNPs was found to be greatly accelerated by Fe (III) and Cu (II) ions in the presence of Cl- ions. Although some of the results here conflict with the literature, developmental toxicity has been observed here, for both Al and Ag, and the variability across studies may provide an opportunity for dissecting the mechanisms behind Al and Ag toxicity through identification of the traits that confer…
Subjects/Keywords: 615.9; drosophila; AgNPs; nanoparticles; developmental toxicity; aluminium toxicity; silver toxicity; aluminum toxicity
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APA (6th Edition):
Clay, R. (2014). Developmental toxicity of aluminium and silver to Drosophila melanogaster. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/developmental-toxicity-of-aluminium-and-silver-to-drosophila-melanogaster(f9d8e295-8ce2-4627-bb38-1dae0998b57f).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756789
Chicago Manual of Style (16th Edition):
Clay, Robert. “Developmental toxicity of aluminium and silver to Drosophila melanogaster.” 2014. Doctoral Dissertation, University of Manchester. Accessed February 26, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/developmental-toxicity-of-aluminium-and-silver-to-drosophila-melanogaster(f9d8e295-8ce2-4627-bb38-1dae0998b57f).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756789.
MLA Handbook (7th Edition):
Clay, Robert. “Developmental toxicity of aluminium and silver to Drosophila melanogaster.” 2014. Web. 26 Feb 2021.
Vancouver:
Clay R. Developmental toxicity of aluminium and silver to Drosophila melanogaster. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Feb 26].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/developmental-toxicity-of-aluminium-and-silver-to-drosophila-melanogaster(f9d8e295-8ce2-4627-bb38-1dae0998b57f).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756789.
Council of Science Editors:
Clay R. Developmental toxicity of aluminium and silver to Drosophila melanogaster. [Doctoral Dissertation]. University of Manchester; 2014. Available from: https://www.research.manchester.ac.uk/portal/en/theses/developmental-toxicity-of-aluminium-and-silver-to-drosophila-melanogaster(f9d8e295-8ce2-4627-bb38-1dae0998b57f).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756789
University of Manchester
16.
Shellard, Philippa.
Functionalised graphene for biomedical
applications.
Degree: 2017, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614
► There has been increasing interest in the use of pristine graphene in biomedical applications, but its use is limited by its hydrophobicity and lack of…
(more)
▼ There has been increasing interest in the use of
pristine graphene in biomedical applications, but its use is
limited by its hydrophobicity and lack of functional groups by
which to tether molecules, meaning that biological applications of
pristine graphene rely on non-specific adsorption of molecules.
Furthermore, pristine graphene cannot be used in-vivo due to its
poor aqueous dispersibility. Functional groups are introduced to
graphene to overcome these problems, but many functionalisation
methods cause significant disruption to the extended π-system of
graphene, from which its favourable properties arise. The aim of
this thesis was to address the limitations of using pristine
graphene outlined above. The solution proposed was the
edge-specific sulfonation and thiol functionalisation of pristine
graphene, based upon electrophilic aromatic substitution. The
nature of these reactions means that they should cause minimal
defect formation, occurring selectively at existing defects and
edges of the graphene sheet. The sulfonation of graphene was
selected to increase the aqueous dispersibility of pristine
graphene, while the thiol functionalisation would provide a means
by which to tether molecules covalently to the graphene sheet. The
functionalisations were confirmed using a range of analyses, which
indicated a low level of new defect formation, as well as
demonstrating both the presence of the target functional groups and
the change in aqueous dispersibility of the graphene sheets.
Furthermore, the functionalisation was shown to be edge-specific by
attaching a fluorescent protein to thiol functional groups on the
edges. G-SO3 was incorporated into a polymer layer-by-layer (LbL)
construct, for use in wound healing applications, together with
analogous constructs containing graphene oxide (GO) and
sulfonate-functionalised GO (GO-SO3). The constructs were
characterised, to assess the effect of different functionalisations
on the coverage of graphene. Analysis confirmed the presence of
G-SO3, GO and GO-SO3 in the constructs, but indicated a lower
graphene coverage for the G-SO3 construct, thought to be a result
of the lower number of functional groups in this material. The
biocompatibility of G-SO3, GO and GO-SO3 LbL constructs was tested
on 3T3 Swiss Albino fibroblast cells and human mesenchymal stem
cells. In addition, the differentiation of stem cells on these
graphene-containing surfaces was monitored and compared to
published work on graphene-family nanomaterials. The
biocompatibility studies revealed that cell adhesion and
proliferation were dictated by extracellular matrix (ECM) protein
adsorption on the LbL constructs. The substrates able to bind
higher amounts of ECM protein were found to show greater cell
adhesion and proliferation, with ECM protein binding correlated to
the roughness and surface chemistry of the constructs. Future
applications would be to introduce alternative functional groups to
graphene, using the principles outlined in this thesis. In
addition, there is potential for the attachment of a…
Advisors/Committee Members: HAIGH, SARAH S, BLANFORD, CHRISTOPHER CF, Flitsch, Sabine, Haigh, Sarah, Blanford, Christopher.
Subjects/Keywords: graphene; toxicity; biocompatibility
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APA ·
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Manager
APA (6th Edition):
Shellard, P. (2017). Functionalised graphene for biomedical
applications. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614
Chicago Manual of Style (16th Edition):
Shellard, Philippa. “Functionalised graphene for biomedical
applications.” 2017. Doctoral Dissertation, University of Manchester. Accessed February 26, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614.
MLA Handbook (7th Edition):
Shellard, Philippa. “Functionalised graphene for biomedical
applications.” 2017. Web. 26 Feb 2021.
Vancouver:
Shellard P. Functionalised graphene for biomedical
applications. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Feb 26].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614.
Council of Science Editors:
Shellard P. Functionalised graphene for biomedical
applications. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614
Brno University of Technology
17.
Marcelová, Štěpánka.
Toxicita nitroderivátů toluenu a produktů jejich transformací: Toxicity of nitroderivatives of toluene and products of their transformations.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/11691
► This work is focused on verification of p-Nitrotoluenu toxicity and compounds resulting from the aerobic transformation, and methyl group oxidation and reduction of nitro. Some…
(more)
▼ This work is focused on verification of p-Nitrotoluenu
toxicity and compounds resulting from the aerobic transformation, and methyl group oxidation and reduction of nitro. Some of these products are not commercially available and had to be made soon.
Toxicity of the substances was determined by
toxicity tests. Were tested root growth inhibition Sinapis alba, which resulted in an inhibitory concentration IC50; test inhibition duckweed Lemna minor , which was also the determination of IC50 inhibitory concentration, and acute
toxicity test Artemia salina, which was observed in mortality and immobility organisms and the test result was an efficient concentration EC50 value. Results of tests are compared in the conclusion of the work and is made evaluation of the
toxicity of individual substances.
Advisors/Committee Members: Bednařík, Karel (advisor), Zlámalová Gargošová, Helena (referee).
Subjects/Keywords: toxicita; testy toxicity; toluen; nitroderiváty; toxicity; tests of toxicity; toluene; nitroderivatives
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APA (6th Edition):
Marcelová, . (2019). Toxicita nitroderivátů toluenu a produktů jejich transformací: Toxicity of nitroderivatives of toluene and products of their transformations. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/11691
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Marcelová, Štěpánka. “Toxicita nitroderivátů toluenu a produktů jejich transformací: Toxicity of nitroderivatives of toluene and products of their transformations.” 2019. Thesis, Brno University of Technology. Accessed February 26, 2021.
http://hdl.handle.net/11012/11691.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Marcelová, Štěpánka. “Toxicita nitroderivátů toluenu a produktů jejich transformací: Toxicity of nitroderivatives of toluene and products of their transformations.” 2019. Web. 26 Feb 2021.
Vancouver:
Marcelová . Toxicita nitroderivátů toluenu a produktů jejich transformací: Toxicity of nitroderivatives of toluene and products of their transformations. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/11012/11691.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Marcelová . Toxicita nitroderivátů toluenu a produktů jejich transformací: Toxicity of nitroderivatives of toluene and products of their transformations. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/11691
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
East Carolina University
18.
Douglas, Chandler D.
The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae.
Degree: MS, Biology, 2012, East Carolina University
URL: http://hdl.handle.net/10342/4087
► Nickel (II) is a common component of many natural products and man-made devices. Due to its frequent use in everyday life, relatively large amounts of…
(more)
▼ Nickel (II) is a common component of many natural products and man-made devices. Due to its frequent use in everyday life, relatively large amounts of nickel are being released into the environment. Nickel, however, is a known carcinogen; therefore, an assay must be developed in order to understand the toxic effects of this heavy metal on living organisms. Nematodes are a model animal species that have been used in sediment and water testing of contaminated environmental samples. Nematodes lend themselves perfectly to liquid and sediment assays due to their easy recovery, handling, distinction between larva and adults, and short life cycle. In this study, we used three nematode species, Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae, in order to determine the effects of nickel on the survival, growth, reproduction, fecundity, and lifespan of these model biotic organisms. During preliminary testing, C. briggsae displayed highly variable results during both sediment and liquid assays. Thus, the majority of testing in this project was performed on C. elegans and P. pacificus. We found that C. elegans is best suited for environmental assays where there is a large portion of dissolved organic carbon in the sediment. However, P. pacificus, displayed no preference for any of the soil physio-chemical characteristics during these assays. The element Nickel (II) can either bind to substrates within a sediment, or can freely move through aqueous solution. In this study, we showed that nickel bound in sediment is highly lethal to the P0 generation of nematodes; however, the effects of nickel bound in sediment were not readily apparent on the F1 generation of both C. elegans and P. pacificus. Using liquid assays, we also determined that aqueous nickel was not detrimental to the P0 generation for all three nematode species. Interestingly, higher dosages of aqueous nickel were shown to be detrimental to the F1 generation for C. elegans, whereas P. pacificus showed no decline in the number of F1 progeny recovered. Finally, our results show that nickel bound in sediment also has an effect on longevity. Using C. elegans strain JK574: Cel-fog-2 (q71) LGV in a longevity trial, it was determined that higher dosages of bound nickel can decrease the number of days needed to reach a 50% recovery rate by 7-8 times. Overall, the results of these experiments show that both C. elegans and P. pacificus can be used as bio-indicators of nickel contaminated water and sediment samples. By developing this quick, efficient, and reliable assay, other laboratories will be able to determine the amount of nickel that can be detrimental in various ecological samples and what the toxic effects of this metal will be on living organisms.
Advisors/Committee Members: Rudel, David (advisor).
Subjects/Keywords: Biology; Toxicity; Nickel – Toxicity testing; Nickel – Environmental aspects; Toxicity testing; Nematodes – Research
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APA (6th Edition):
Douglas, C. D. (2012). The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae. (Masters Thesis). East Carolina University. Retrieved from http://hdl.handle.net/10342/4087
Chicago Manual of Style (16th Edition):
Douglas, Chandler D. “The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae.” 2012. Masters Thesis, East Carolina University. Accessed February 26, 2021.
http://hdl.handle.net/10342/4087.
MLA Handbook (7th Edition):
Douglas, Chandler D. “The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae.” 2012. Web. 26 Feb 2021.
Vancouver:
Douglas CD. The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae. [Internet] [Masters thesis]. East Carolina University; 2012. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10342/4087.
Council of Science Editors:
Douglas CD. The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae. [Masters Thesis]. East Carolina University; 2012. Available from: http://hdl.handle.net/10342/4087
University of Zambia
19.
Mulindwa, Jessica.
A study of Nevirapine toxicity in HIV Infected pregnant women at the University Teaching Hospital in Lusaka, Zambia
.
Degree: 2012, University of Zambia
URL: http://hdl.handle.net/123456789/1877
► Background: The toxicity of nevirapine based regimen in pregnant women with CD4 counts greater than 250 cells/mm3 is well documented. WHO as well as the…
(more)
▼ Background: The toxicity of nevirapine based regimen in pregnant women with CD4 counts greater than 250 cells/mm3 is well documented. WHO as well as the United States Food and Drug Agency (US FDA) cautions use of nevirapine in pregnant women with CD4 counts greater than 250 cells/mm3. The Zambian guidelines recommend initiating HAART for all HIV positive pregnant women with CD4 counts less than 350 cells/mm3. Nevirapine based regimen is the recommended first line, even for CD4 counts between 250 to 350cell/mm3. We compared incidence of nevirapine toxicity in pregnant HIV infected women commenced on a nevirapine based regimen in pregnancy with CD4 counts less than 250 cells/mm3 to that of women with CD4 counts between 250 and 350 cells/mm3. Methods: Longitudinal observational study with 2 arms; CD4 count below 250 cells/ mm3, and CD4 count of 250-350 cells/ mm3. Convenience sampling was used to enroll 146 patients. All HIV infected pregnant women with CD4 counts less than or equal to 350cells/mm3 commenced on nevirapine based regimen in the current pregnancy were enrolled if they consented and they fulfilled the eligibility criteria. Women were allocated to the 2 arms based on their CD4 count. An interviewer administered questionnaire was used to collect demographic details at the recruitment stage. On subsequent visits, a check list was used to collect data.SAS statistical package was used to analyze the data. Results: The incidence of nevirapine toxicity Rash (at least grade 2 rash with or without mucous membrane involvement and/or at least grade 2 rise in Aspartate Amino Transferase)was found to be 0% in women with CD4 counts below 250cells/mm3; it was 13.5%
(p=0.005) in women with CD4 counts between 250 to 350cell/mm3.Conclusions:Though the study was powered to detect a 15% difference, the results of the study show that women with CD4 counts of 250 to 350cells/mm3 are at substantial risk of nevirapine toxicity when commenced on nevirapine based HAART regimen in pregnancy
Subjects/Keywords: Nevirapine Toxicity;
Gynecology – Diagnosis
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APA ·
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Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Mulindwa, J. (2012). A study of Nevirapine toxicity in HIV Infected pregnant women at the University Teaching Hospital in Lusaka, Zambia
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1877
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mulindwa, Jessica. “A study of Nevirapine toxicity in HIV Infected pregnant women at the University Teaching Hospital in Lusaka, Zambia
.” 2012. Thesis, University of Zambia. Accessed February 26, 2021.
http://hdl.handle.net/123456789/1877.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mulindwa, Jessica. “A study of Nevirapine toxicity in HIV Infected pregnant women at the University Teaching Hospital in Lusaka, Zambia
.” 2012. Web. 26 Feb 2021.
Vancouver:
Mulindwa J. A study of Nevirapine toxicity in HIV Infected pregnant women at the University Teaching Hospital in Lusaka, Zambia
. [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/123456789/1877.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mulindwa J. A study of Nevirapine toxicity in HIV Infected pregnant women at the University Teaching Hospital in Lusaka, Zambia
. [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1877
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Gopinathan,C P.
Studies on the Phytoplankton in the Estuarine and Marine Environments.
Degree: Marine Science;, 1983, Cochin University of Science and Technology
URL: http://dyuthi.cusat.ac.in/purl/1148
Subjects/Keywords: Phytoplankton; Toxicity
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Export
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APA (6th Edition):
P, G. (1983). Studies on the Phytoplankton in the Estuarine and Marine Environments. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/1148
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
P, Gopinathan,C. “Studies on the Phytoplankton in the Estuarine and Marine Environments.” 1983. Thesis, Cochin University of Science and Technology. Accessed February 26, 2021.
http://dyuthi.cusat.ac.in/purl/1148.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
P, Gopinathan,C. “Studies on the Phytoplankton in the Estuarine and Marine Environments.” 1983. Web. 26 Feb 2021.
Vancouver:
P G. Studies on the Phytoplankton in the Estuarine and Marine Environments. [Internet] [Thesis]. Cochin University of Science and Technology; 1983. [cited 2021 Feb 26].
Available from: http://dyuthi.cusat.ac.in/purl/1148.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
P G. Studies on the Phytoplankton in the Estuarine and Marine Environments. [Thesis]. Cochin University of Science and Technology; 1983. Available from: http://dyuthi.cusat.ac.in/purl/1148
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mississippi State University
21.
Russell, David Pierce.
Controlling forage weed species detrimental to livestock production.
Degree: PhD, Plant and Soil Sciences, 2017, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10242017-093433/
;
► Among the vast diversity of plants in the mid-South to which grazing livestock are exposed, there is a need to address certain species that are…
(more)
▼ Among the vast diversity of plants in the mid-South to which grazing livestock are exposed, there is a need to address certain species that are potentially harmful to livestock health and production. Field and greenhouse experiments were conducted on endophyte-infected tall fescue [<i>Schedonorus arundinaceus</i> (Schreb.) Dumort = <i>Lolium arundinaceum</i> (Schreb.) Darbysh.], a cool-season perennial forage, and perilla mint, (<i>Perilla frutescens</i> (L.) Britton) an herbaceous annual, to determine management techniques and control measures for healthier pasture and livestock systems. When seedheads reached maturity, spring and autumn glyphosate applications at 1.68 kg ae ha
-1, coupled with autumn tillage and summer and winter cover crops effectively reduced tall fescue coverage to < 27% by 10 months after initial treatment (MAT) following a single year of management. If seedhead maturity is inhibited prior to first glyphosate application, tall fescue was reduced to <1% coverage 10 MAT. Despite seedhead suppression, at least 78% increase in coverage occurred in 24 months from remnant populations suggesting two years of renovation is required. Forage soybeans proved to be a valuable cover crop that maintained nutritive quality and mean dry matter yields of 5487 kg ha
-1 across two years. Tall fescue seedheads were suppressed below 14% coverage (> 68% visual control) by nicosulfuron + metsulfuron (20 + 5 and 40 +11 g ai ha
-1), imazapic (26 and 53 g ai ha
-1), and sulfosulfuron (53 g ai ha
-1) at 90 DAT. Reduction in forage heights may be expected, but was not consistently reduced when compared to untreated plots across locations.
To control perilla mint, postemergence applications of aminocyclopyrachlor blends, glyphosate, picloram + 2,4-D, aminopyralid + 2,4-D, and 2,4-D alone provided superior control when applied prior to the plants reproductive growth stage. Picloram + 2,4-D also provided in-field soil residual activity and the most effective preemergence control, followed by aminocyclopyrachlor + chlorsulfuron, pendimethalin, and aminopyralid + 2,4-D for at least 141 DAT. Seed from weedy populations in north Mississippi tend to germinate in a range of night/day soil temperatures from 10/15 C to 25/30 C. Therefore, effective preemergence treatments should be applied by mid- to late- February in this region.
Advisors/Committee Members: John D. Byrd (chair), Jane A. Parish (committee member), Daniel B. Reynolds (committee member), J. Mike Phillips (committee member), Gary N. Ervin (committee member).
Subjects/Keywords: livestock; weeds; renovation; toxicity; management
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APA (6th Edition):
Russell, D. P. (2017). Controlling forage weed species detrimental to livestock production. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-10242017-093433/ ;
Chicago Manual of Style (16th Edition):
Russell, David Pierce. “Controlling forage weed species detrimental to livestock production.” 2017. Doctoral Dissertation, Mississippi State University. Accessed February 26, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-10242017-093433/ ;.
MLA Handbook (7th Edition):
Russell, David Pierce. “Controlling forage weed species detrimental to livestock production.” 2017. Web. 26 Feb 2021.
Vancouver:
Russell DP. Controlling forage weed species detrimental to livestock production. [Internet] [Doctoral dissertation]. Mississippi State University; 2017. [cited 2021 Feb 26].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10242017-093433/ ;.
Council of Science Editors:
Russell DP. Controlling forage weed species detrimental to livestock production. [Doctoral Dissertation]. Mississippi State University; 2017. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10242017-093433/ ;
University of Utah
22.
Johnson-Davis, Kamisha Lynnette.
Methamphetamine and mechanisms underlying tolerance to its neurotoxic effects.
Degree: PhD, Pharmacology & Toxicology;, 2004, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/762/rec/760
► Previous studies have demonstrated that pretreating with multiple injections of escalating doses of methamphetamine (METH) induces tolerance to the long-term neurotoxic effects of METH on…
(more)
▼ Previous studies have demonstrated that pretreating with multiple injections of escalating doses of methamphetamine (METH) induces tolerance to the long-term neurotoxic effects of METH on dopamine (DA) neurons. The mechanism(s) underlying this tolerance phenomenon is (are) unknown. Recent studies suggested that aberrant vesicular monoamine transporter-2 (VMAT-2) and DA transporter function contribute to the neurotoxic effects of METH. Hence, the purpose of this study was to explore the role of the VMAT-2 and DA transporter in the induction of tolerance to the long-term persistent dopaminergic and serotonergic deficits caused by METH. A second purpose was to investigate the potential role of hyperthermia and alterations in brain METH distribution in this tolerance. Thus, we hypothesize that tolerance to the neurotoxic effects of METH is possibly due to either a shift in the drug distribution of METH in the brain and/or the prevention of METH-induced alterations in monoamine transporter function. Data from this dissertation revealed that the protection from METH pretreatment was not due to changes in the distribution of METH in the brain, as both the METH-pretreated and saline-pretreated rats had similar amounts of METH and amphetamine (AMP) in the brain after the last METH challenge injection. Depending on the dosing protocol employed, the METH pretreatment regimen could slightly attenuate METH-induced hyperthermia during the challenge administration, thus possibly contributing to the protection against long-term monoamine depletion. METH pretreatment regimen attenuated both the acute METH-induced decrease in VMAT-2 function 2 h after the METH challenge administration and its resulting persistent DA deficits in the striatum as well as serotonin (5-HT) deficits in the hippocampus. However, the pretreatment regimen did not produce tolerance by altering the acute METH-induced decrease in DA transporter uptake. Furthermore, pretreatment with METH prior to a high-dose METH challenge administration also attenuated the acute METH-induced redistribution of VMAT-2 immunoreactivity within the nerve terminal. In summary, these data are the first to demonstrate an association between the prevention of acute alterations in vesicular DA uptake and the development of tolerance to the neurotoxic effects of METH.
Subjects/Keywords: Physiology; Toxicity
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APA (6th Edition):
Johnson-Davis, K. L. (2004). Methamphetamine and mechanisms underlying tolerance to its neurotoxic effects. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/762/rec/760
Chicago Manual of Style (16th Edition):
Johnson-Davis, Kamisha Lynnette. “Methamphetamine and mechanisms underlying tolerance to its neurotoxic effects.” 2004. Doctoral Dissertation, University of Utah. Accessed February 26, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/762/rec/760.
MLA Handbook (7th Edition):
Johnson-Davis, Kamisha Lynnette. “Methamphetamine and mechanisms underlying tolerance to its neurotoxic effects.” 2004. Web. 26 Feb 2021.
Vancouver:
Johnson-Davis KL. Methamphetamine and mechanisms underlying tolerance to its neurotoxic effects. [Internet] [Doctoral dissertation]. University of Utah; 2004. [cited 2021 Feb 26].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/762/rec/760.
Council of Science Editors:
Johnson-Davis KL. Methamphetamine and mechanisms underlying tolerance to its neurotoxic effects. [Doctoral Dissertation]. University of Utah; 2004. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/762/rec/760
University of Utah
23.
Downes, James Denny Carville.
Tungsten inert gas welding on stainless steel: a hazard evaluation;.
Degree: MS;, Family & Preventive Medicine;, 1986, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1374/rec/1427
► The mean iron, chromium, hexavalent chromium, chromium, nickel, and manganese levels were found to be will below the TLV-TWA set by ACGIH. The hexavalen chromium…
(more)
▼ The mean iron, chromium, hexavalent chromium, chromium, nickel, and manganese levels were found to be will below the TLV-TWA set by ACGIH. The hexavalen chromium (total of soluble and insoluble Cr+6) mean was equal to the NIOSH proposed standard for water insoluble hexavalent chromium. The mean nickel concentration was slightly below the NIOSH proposed standard. Ozone was found at levels 16 times higher that the ACHIH standard in the plume but none was found inside the welder’s helmet. Nitrogen dioxide and carbon monoxide were not found in significant amounts. The quantities of ozone found warrants more extensive sampling in future studies. This study supports previous studies which demonstrate that the welding helmet provides protection against welding fumes and gases. The protection factor ranged from 0.92 to 7.2. TIG welding on stainless steel, as conducted at the Idaho Chemical Processing Plant, and based on the levels set by the ACGIH, is a safe operation.
Subjects/Keywords: Standards; Toxicity
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APA (6th Edition):
Downes, J. D. C. (1986). Tungsten inert gas welding on stainless steel: a hazard evaluation;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1374/rec/1427
Chicago Manual of Style (16th Edition):
Downes, James Denny Carville. “Tungsten inert gas welding on stainless steel: a hazard evaluation;.” 1986. Masters Thesis, University of Utah. Accessed February 26, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1374/rec/1427.
MLA Handbook (7th Edition):
Downes, James Denny Carville. “Tungsten inert gas welding on stainless steel: a hazard evaluation;.” 1986. Web. 26 Feb 2021.
Vancouver:
Downes JDC. Tungsten inert gas welding on stainless steel: a hazard evaluation;. [Internet] [Masters thesis]. University of Utah; 1986. [cited 2021 Feb 26].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1374/rec/1427.
Council of Science Editors:
Downes JDC. Tungsten inert gas welding on stainless steel: a hazard evaluation;. [Masters Thesis]. University of Utah; 1986. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1374/rec/1427
University of Alberta
24.
Wang, Nan.
Ozonation and biodegradation of oil sands process
water.
Degree: MS, Department of Civil and Environmental
Engineering, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/5x21tg63p
► To ensure oil sands process water (OSPW) is suitable for discharge into the environment, advanced water treatment technologies are required. In this study, integrated ozonation-biodegradation…
(more)
▼ To ensure oil sands process water (OSPW) is suitable
for discharge into the environment, advanced water treatment
technologies are required. In this study, integrated
ozonation-biodegradation was investigated as a potential treatment
option for OSPW. The treatment efficiency was evaluated in terms of
naphthenic acid (NA) degradation, chemical oxygen demand (COD),
carbonaceous Biological oxygen demand (CBOD), and acute toxicity
reduction. Degradation of NAs of more than 99% was achieved using a
semi-batch ozonation system at a utilized ozone dose of 80 mg/L
combined with subsequent biodegradation. The results also show that
ozone decreased the amount of COD while increasing the
biodegradability of COD. It was noted that the carbon number and
number of NA rings influenced the level of NA oxidation. With a
utilized ozone dose of approximately 100 mg/L, the ozonated and
biodegraded treated OSPW showed no toxic effect towards bacterium
Vibrio fischeri. The results of this study indicate that integrated
ozonation-biodegradation is a promising treatment technology for
OSPW.
Subjects/Keywords: ozonation; naphthenic acid; toxicity; biodegradation
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Manager
APA (6th Edition):
Wang, N. (2011). Ozonation and biodegradation of oil sands process
water. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/5x21tg63p
Chicago Manual of Style (16th Edition):
Wang, Nan. “Ozonation and biodegradation of oil sands process
water.” 2011. Masters Thesis, University of Alberta. Accessed February 26, 2021.
https://era.library.ualberta.ca/files/5x21tg63p.
MLA Handbook (7th Edition):
Wang, Nan. “Ozonation and biodegradation of oil sands process
water.” 2011. Web. 26 Feb 2021.
Vancouver:
Wang N. Ozonation and biodegradation of oil sands process
water. [Internet] [Masters thesis]. University of Alberta; 2011. [cited 2021 Feb 26].
Available from: https://era.library.ualberta.ca/files/5x21tg63p.
Council of Science Editors:
Wang N. Ozonation and biodegradation of oil sands process
water. [Masters Thesis]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/5x21tg63p
25.
Meenakshi, S.
Studies on defluoridation of water with a few adsorbents
and development of an indigenous defluoridation unit for domestic
use;.
Degree: 2014, INFLIBNET
URL: http://shodhganga.inflibnet.ac.in/handle/10603/16564
► This thesis embodies the results of the laboratory studies on defluoridation of water with a few selected adsorbents. Based on these results an indigenous defluoridation…
(more)
▼ This thesis embodies the results of the laboratory
studies on defluoridation of water with a few selected adsorbents.
Based on these results an indigenous defluoridation unit at
domestic level is developed, the design and specification of which
are also given. Field trials and the success of those trials are
also discussed. newline newlineThe thesis is divided into three
main chapters. In the first chapter a general introduction on
fluoride toxicity, an over view of fluoride levels in naturally
occurring water sources, fluoride bearing minerals in India and a
review of various defluoridating agents studied so far in the
literature are given in detail. newlineThe second chapter deals
with the laboratory studies with a few selected adsorbents viz.
magnesium oxide, activated alumina, tricalcium phosphate and bone
charcoal for defluoridation of water. The methodology for the
experimental determination of defluoridation capacities of the
adsorbents is presented. Experimental details regarding the studies
on the effect of certain variables like time period of contact,
particle size, pH, temperature, concentrations of fluoride ion and
concentrations of other ions like chloride, sulphate and
bicarbonate are also presented. Determination of fluoride using the
ion selective electrode method is described. Results of the
experiments carried out are analysed in order to choose the best
adsorbent material for development of an indigenous defluoridation
unit. The mechanistic aspects of defluoridation of water with
respect to each of the adsorbents are thoroughly discussed.
newlineThe third chapter presents the details of the design and
specifications of the model developed, cost analysis and results of
the field trials. The performance of this unit and its
acceptability by the users are presented in detail. newlineA
consolidated list of references consulted is given at the end of
the thesis to facilitate easy reference; references pertaining to
each chapter are not separately listed to avoid duplication.
newline newline
Advisors/Committee Members: Karthikeyan, G.
Subjects/Keywords: Defluoridation; Fluoride Toxicity; Water
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APA (6th Edition):
Meenakshi, S. (2014). Studies on defluoridation of water with a few adsorbents
and development of an indigenous defluoridation unit for domestic
use;. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/16564
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Meenakshi, S. “Studies on defluoridation of water with a few adsorbents
and development of an indigenous defluoridation unit for domestic
use;.” 2014. Thesis, INFLIBNET. Accessed February 26, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/16564.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Meenakshi, S. “Studies on defluoridation of water with a few adsorbents
and development of an indigenous defluoridation unit for domestic
use;.” 2014. Web. 26 Feb 2021.
Vancouver:
Meenakshi S. Studies on defluoridation of water with a few adsorbents
and development of an indigenous defluoridation unit for domestic
use;. [Internet] [Thesis]. INFLIBNET; 2014. [cited 2021 Feb 26].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16564.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Meenakshi S. Studies on defluoridation of water with a few adsorbents
and development of an indigenous defluoridation unit for domestic
use;. [Thesis]. INFLIBNET; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16564
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
26.
Jadhav, Vikas Viswas.
Toxicity and risk assessment of bisphenol a; -.
Degree: Environmental Science, 2014, Shivaji University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/50418
None
Bibliography p.111 - 124
Advisors/Committee Members: Raut, P D.Subjects/Keywords: Assessment; Toxicity
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APA (6th Edition):
Jadhav, V. V. (2014). Toxicity and risk assessment of bisphenol a; -. (Thesis). Shivaji University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/50418
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Jadhav, Vikas Viswas. “Toxicity and risk assessment of bisphenol a; -.” 2014. Thesis, Shivaji University. Accessed February 26, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/50418.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Jadhav, Vikas Viswas. “Toxicity and risk assessment of bisphenol a; -.” 2014. Web. 26 Feb 2021.
Vancouver:
Jadhav VV. Toxicity and risk assessment of bisphenol a; -. [Internet] [Thesis]. Shivaji University; 2014. [cited 2021 Feb 26].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/50418.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Jadhav VV. Toxicity and risk assessment of bisphenol a; -. [Thesis]. Shivaji University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/50418
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
Wani, Parvaze Ahmad.
Heavy metal toxicity to plant growth promoting
rhizobacteria, PGPR and certain legume crops;.
Degree: Agricultural Microbiology, 2008, Aligarh Muslim University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/53606
Abstract available newline newline
Summary p. 298-315, Bibliography p. 261-293,
Appendix p. 294-297
Advisors/Committee Members: Khan, Mohd Saghir.Subjects/Keywords: Toxicity; Rhizobacteria; Promoting; Legume;
Growth
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APA (6th Edition):
Wani, P. A. (2008). Heavy metal toxicity to plant growth promoting
rhizobacteria, PGPR and certain legume crops;. (Thesis). Aligarh Muslim University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/53606
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wani, Parvaze Ahmad. “Heavy metal toxicity to plant growth promoting
rhizobacteria, PGPR and certain legume crops;.” 2008. Thesis, Aligarh Muslim University. Accessed February 26, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/53606.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wani, Parvaze Ahmad. “Heavy metal toxicity to plant growth promoting
rhizobacteria, PGPR and certain legume crops;.” 2008. Web. 26 Feb 2021.
Vancouver:
Wani PA. Heavy metal toxicity to plant growth promoting
rhizobacteria, PGPR and certain legume crops;. [Internet] [Thesis]. Aligarh Muslim University; 2008. [cited 2021 Feb 26].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/53606.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wani PA. Heavy metal toxicity to plant growth promoting
rhizobacteria, PGPR and certain legume crops;. [Thesis]. Aligarh Muslim University; 2008. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/53606
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
28.
Martin, Jonathan.
Comparative toxicity and bioavailability of heavy fuel oils to fish using different exposure scenarios
.
Degree: Biology, 2011, Queens University
URL: http://hdl.handle.net/1974/6610
► Heavy fuel oils (HFO) are produced from the refining of crude oils, and have high specific gravities and high viscosities. In recent years, spills of…
(more)
▼ Heavy fuel oils (HFO) are produced from the refining of crude oils, and have high
specific gravities and high viscosities. In recent years, spills of HFO have increased in the environment, and are of great concern because they are difficult to clean up. Spilled HFO is likely to become submerged, and can become stranded if fresh HFO coats benthic substrates or if weathered HFO sinks as tarballs. Conversely, lighter oils float on the surface and their components disperse and become diluted in the water column. There is a research need to assess the unique ecological risks of HFO that can sink and contaminate spawning shoals of fish. Chronic toxicity of HFO to fish embryos is
correlated with exposure to polycyclic aromatic hydrocarbon (PAH) that become
bioavailable from spilled HFO to identify under which spill conditions fish populations
are at greatest risk. The results of this research demonstrate that: (1) Stranded HFO is a significant source of PAH to the receiving environment and causes chronic toxicity to embryonic fish; (2) Tarballs and weathered HFO cause less toxicity than fresh HFO, likely a consequence of physical limitations to PAH release; (3) HFO 7102 samples collected from an HFO spill in Wabamun Lake, Alberta, are less toxic than HFO 6303; (4) HFO is at least 2-fold more toxic than Medium South American (MESA), a well-studied reference crude oil, coincident with 3-fold higher concentrations of alkyl PAH, namely alkyl phenanthrenes.
Subjects/Keywords: Toxicity
;
Heavy fuel oil
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Manager
APA (6th Edition):
Martin, J. (2011). Comparative toxicity and bioavailability of heavy fuel oils to fish using different exposure scenarios
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6610
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Martin, Jonathan. “Comparative toxicity and bioavailability of heavy fuel oils to fish using different exposure scenarios
.” 2011. Thesis, Queens University. Accessed February 26, 2021.
http://hdl.handle.net/1974/6610.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Martin, Jonathan. “Comparative toxicity and bioavailability of heavy fuel oils to fish using different exposure scenarios
.” 2011. Web. 26 Feb 2021.
Vancouver:
Martin J. Comparative toxicity and bioavailability of heavy fuel oils to fish using different exposure scenarios
. [Internet] [Thesis]. Queens University; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1974/6610.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Martin J. Comparative toxicity and bioavailability of heavy fuel oils to fish using different exposure scenarios
. [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6610
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
29.
Lin, Hongkang.
The toxicity of alkyl-chrysenes and benz[a]anthracenes to embryonic fish
.
Degree: Biology, 2014, Queens University
URL: http://hdl.handle.net/1974/8550
► Alkylated polycyclic aromatic hydrocarbons (alkyl-PAHs) are major constituents of crude oil, and the 3-5 ringed alkyl-PAHs have been identified as the main components chronically toxic…
(more)
▼ Alkylated polycyclic aromatic hydrocarbons (alkyl-PAHs) are major constituents of crude oil, and the 3-5 ringed alkyl-PAHs have been identified as the main components chronically toxic to fish. While chysene homologues have higher cytochrome P4501A (CYP1A) induction potencies than alkyl-phenanthrenes, there is little characterization of toxicity for 4-ringed alkyl PAHs. This study measured the chronic toxicity of chrysene, benz[α]anthracene, and some alkylated congeners to the embryos of Japanese medaka (Oryzias latipes) using the partition-controlled delivery method (PCD) of exposure. This exposure method relies on the partitioning of chemicals from polydimethylsiloxane (PDMS) films, loaded with various concentrations of test chemical, to embryo rearing solutions. The objectives of this thesis were: (1) to further characterize the PCD method with a series of 4-ringed PAHs; (2) to evaluate the effects of different chemical structures on the toxicity of test compounds; and (3) to extend structure toxicity relationships from alkyl-phenanthrenes. The PCD method generated a gradient of aqueous concentrations for test compounds, and these exposure concentrations were maintained constant for the 17-day period. Benz[α]anthracene showed higher toxicity than chrysene. Toxicity increased with the degree of alkylation on the ring structures, except that 2-methylbenz[α]anthracene was less toxic than the unsubstituted benz[α]anthracene. Substitutions at the middle region contributed to a higher toxicity than substitutions at the distal region. While actual mechanisms for these compounds to cause toxicity are unknown, the narcotic mode of action seems to be not involved due to the lack of mortality. Within the range of test concentrations, the chronic sublethal toxicity was limited by the low solubility of the test compounds. A structure toxicity relationship was illustrated by the regression between log EC50s and log Kow values. In addition to hydrophobicity represented by log Kow, structural dissimilarities between compounds and physical characteristics such as aqueous solubility limits should be taken into account in toxicity assessments with alkyl-PAHs. This research is the first toxicological assessment of alkyl-chrysenes and benz[α]anthracenes which is essential for a better understanding of structure toxicity relationships of alkyl-PAHs, and will contribute to more accurate ecological risk assessments of PAH contamination.
Subjects/Keywords: alkyl-PAHs
;
chronic toxicity
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APA (6th Edition):
Lin, H. (2014). The toxicity of alkyl-chrysenes and benz[a]anthracenes to embryonic fish
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8550
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lin, Hongkang. “The toxicity of alkyl-chrysenes and benz[a]anthracenes to embryonic fish
.” 2014. Thesis, Queens University. Accessed February 26, 2021.
http://hdl.handle.net/1974/8550.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lin, Hongkang. “The toxicity of alkyl-chrysenes and benz[a]anthracenes to embryonic fish
.” 2014. Web. 26 Feb 2021.
Vancouver:
Lin H. The toxicity of alkyl-chrysenes and benz[a]anthracenes to embryonic fish
. [Internet] [Thesis]. Queens University; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1974/8550.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lin H. The toxicity of alkyl-chrysenes and benz[a]anthracenes to embryonic fish
. [Thesis]. Queens University; 2014. Available from: http://hdl.handle.net/1974/8550
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
30.
Cloete, Yolandi Clignet.
The development of preliminary laboratory based culture methods for selected macro-invertebrates used in sediment toxicity testing.
Degree: 2013, University of Johannesburg
URL: http://hdl.handle.net/10210/8547
► M.Sc. (Aquatic Health)
Sediments can contain a variety of organic and inorganic contaminants. These contaminants accumulate, resulting in extremely high concentrations even once the overlying…
(more)
▼ M.Sc. (Aquatic Health)
Sediments can contain a variety of organic and inorganic contaminants. These contaminants accumulate, resulting in extremely high concentrations even once the overlying water concentrations are at or below acceptable water quality guidelines. Any changes in the physical parameters of the overlying water can cause these pollutants to be released back into solution. Accumulated contaminants can be released at even higher concentrations than previously detected. In recent years, sediment contamination has highlighted the need to monitor these previously overlooked pollutant sources that have accumulated in aquatic ecosystems. South Africa does not currently have standardised methods to assess sediment toxicity. Although international methods exist, they are largely untested in South Africa and the organisms needed to conduct these tests are not readily available. Over the years numerous culture methods have been develop globally for culturing organism to be used for water and sediment toxicity tests. In South Africa, the focus has mainly been on culturing organisms for water toxicity testing. Sediment toxicity testing with indigenous organism however, was not developed. Established international culture methods from the United States Environmental Protection Agency, the Organisation for Economic Cooperation and Development, and Environment Canada were taken into consideration when developing the laboratory culture method for two(2) of the selected organisms (Chironomus spp. & Hydra sp.) from this study. A preliminary culture method was also developed for the third selected organism, Melanoides tuberculata (gastropod). The organisms cultured in this study were selected based on their extent of contact with the substrate, ease of handling, availability, culture maintenance as well as their reproductive cycle. The Hydra, Chironomids and M. tuberculata cultures were successfully breeding under laboratory conditions and remained stable. The Chironomus sp. and M. tuberculata maintain contact with the sediment making them suitable as ecologically relevant organisms for use in whole sediment toxicity testing in South Africa.
Subjects/Keywords: Water quality bioassay - Standards; Sediment control; Toxicity testing; Chironomus - Toxicity testing; Melanoides tuberculata - Toxicity testing; Hydra, Chironomids - Toxicity testing
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cloete, Y. C. (2013). The development of preliminary laboratory based culture methods for selected macro-invertebrates used in sediment toxicity testing. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/8547
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cloete, Yolandi Clignet. “The development of preliminary laboratory based culture methods for selected macro-invertebrates used in sediment toxicity testing.” 2013. Thesis, University of Johannesburg. Accessed February 26, 2021.
http://hdl.handle.net/10210/8547.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cloete, Yolandi Clignet. “The development of preliminary laboratory based culture methods for selected macro-invertebrates used in sediment toxicity testing.” 2013. Web. 26 Feb 2021.
Vancouver:
Cloete YC. The development of preliminary laboratory based culture methods for selected macro-invertebrates used in sediment toxicity testing. [Internet] [Thesis]. University of Johannesburg; 2013. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10210/8547.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cloete YC. The development of preliminary laboratory based culture methods for selected macro-invertebrates used in sediment toxicity testing. [Thesis]. University of Johannesburg; 2013. Available from: http://hdl.handle.net/10210/8547
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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