subject:(Total neuropathy score)

You searched for subject:(Total neuropathy score). Showing records 1 – 2 of 2 total matches.

▼ Search Limiters

Freie Universität Berlin

1. Lieber, Sascha. Chemotherapy-induced peripheral neuropathy in survivors of pediatric acute lymphoblastic leukemia.

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-26052

Background: Chemotherapy-induced Peripheral Neuropathy (CIPN) is a common sequel in pediatric survivors of acute lymphoblastic leukemia (ALL) and mainly caused by the vinca alkaloid Vincristine (VCR). We aimed at describing large and small-fiber toxicity as well as pain sensitization in this group. Methods: In a cross-sectional, bicentric study we assessed survivors of pediatric ALL. Inclusion criteria were an age above 6 years, a lag time of at least 3 months after last administration of VCR, a cumulative dose of VCR of 12 mg/m2 and no relapse. We used a reduced version of the Pediatric-modified Total Neuropathy Score (ped-mTNS) as bedside test and Quantitative Sensory Testing (QST) for assessment of small- and large-fiber neuropathy, as well as of pain sensitization. We employed nerve conduction studies (NCS) as the most accurate tool for detecting large-fiber neuropathy. Results: We assessed 46 survivors, of whom 28 were male. Mean age was 9.8 ± 3.1 years SD. Median lag time after therapy was 2.5 years. Fifteen survivors (33%) had abnormal rPed-mTNS values (≥ 4 points) and 5 survivors (11%) reported chronic pain conditions. In QST the survivor group showed significant (p<0.001) inferior large-fiber function and pain sensitization when compared to healthy matched peers. We identified deficits of vibration detection in 33 (72%), tactile hypoesthesia in 29 (63%), hyperalgesia to blunt pressure in 19 (41%), increased mechanical pain sensitivity in 12 (26%), and allodynia in 16 (35%) of 46 survivors. Only 7 survivors (15%) had pathologic NCS. Conclusion: QST is a sensitive tool that revealed signs of large-fiber neuropathy in two thirds, small-fiber neuropathy and pain sensitization each in one third of our survivor cohort. Prospective studies using QST in pediatric oncology shall elucidate the pathophysiology of small-fiber neuropathy and pain sensitization as well as their relevance for quality of survival. Advisors/Committee Members: male (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: acute lymphoblastic leukemia; chemotherapy-induced peripheral neuropathy; pediatric-modified total neuropathy score; quantitative sensory testing; small- and large nerve fibers; pain sensitization; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lieber, S. (2019). Chemotherapy-induced peripheral neuropathy in survivors of pediatric acute lymphoblastic leukemia. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-26052

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lieber, Sascha. “Chemotherapy-induced peripheral neuropathy in survivors of pediatric acute lymphoblastic leukemia.” 2019. Thesis, Freie Universität Berlin. Accessed February 28, 2021. http://dx.doi.org/10.17169/refubium-26052.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lieber, Sascha. “Chemotherapy-induced peripheral neuropathy in survivors of pediatric acute lymphoblastic leukemia.” 2019. Web. 28 Feb 2021.

Vancouver:

Lieber S. Chemotherapy-induced peripheral neuropathy in survivors of pediatric acute lymphoblastic leukemia. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2021 Feb 28]. Available from: http://dx.doi.org/10.17169/refubium-26052.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lieber S. Chemotherapy-induced peripheral neuropathy in survivors of pediatric acute lymphoblastic leukemia. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-26052

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

2. Tummanapalli, Shyam Sunder. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.

Degree: Optometry & Vision Science, 2020, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

Background: Corneal nerve fibers express diffusible, trophic neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) into tears in response to neurogenic inflammation. Impaired corneal nerve fibers have been proposed as early indicators of diabetic peripheral neuropathy (DPN). However, the changes that occur in the concentration of these neuropeptides and their relationship with peripheral neuropathy in the diabetic cohort has not been explored.Aim: To demonstrate the changes the concentrations of substance P and CGRP in tears as a result of corneal denervation in diabetes and their association with severity of DPN. Methods: The concentrations of substance P and CGRP in flush tears were measured by enzyme-linked immunosorbent assay. Corneal nerve fibers were assessed using corneal confocal microscopy. Motor nerve axonal excitability tests were conducted to assess axonal function.Results: Age was identified as a confounding factor and controlled in all subsequent studies. Corneal nerve fiber loss was associated with early markers of axonal dysfunction and severity of neuropathy in type 1 diabetes, suggesting that corneal nerve loss is a generalized neuropathic process. There was a significant reduction in the concentration of substance P in tears in people with type 1 diabetic neuropathy. The concentration of substance P in tears was associated with corneal nerve loss and with the severity of peripheral neuropathy in type 1 diabetes. In type 2 diabetes, there was no difference in neuropeptides between groups, regardless of neuropathic status. In both type 1 and type 2 diabetes, corneal nerve parameters were significantly decreased in DPN. Corneal confocal microscopy had a better diagnostic performance than the nerve excitability measures for detecting DPN in a cohort of participants with type 1 and type 2 diabetes. Tear film substance P concentration had a relatively good diagnostic efficiency in the assessment of DPN and may be used as a potential proxy marker for peripheral neuropathy in type 1 diabetes, but not in type 2 diabetes. The co-existence of renal dysfunction with diabetes does have an added detrimental effect on corneal small nerve fibers.Conclusion: The ocular surface can indeed be a useful means to detect peripheral neuropathic status in diabetes. The measurement of tear film substance P offers significant promise in the detection of DPN. Advisors/Committee Members: Markoulli, Maria, Optometry & Vision Science, Faculty of Science, UNSW, Willcox, Mark, Optometry & Vision Science, Faculty of Science, UNSW, Poynten, Ann, Department of Endocrinology, Prince of Wales Hospital, Sydney.

Subjects/Keywords: Tear neuropeptide; Diabetic peripheral neuropathy; Corneal confocal microscopy; Total neuropathy score; Type 2 diabetes; Tear film; Corneal nerves; Nerve excitability studies; Substance P; Calcitonin gene-related peptide; Chronic kidney disease; Flush tears; Inferior whorl; Fractal dimension; Type 1 diabetes

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tummanapalli, S. S. (2020). Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Doctoral Dissertation, University of New South Wales. Accessed February 28, 2021. http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Web. 28 Feb 2021.

Vancouver:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Internet] [Doctoral dissertation]. University of New South Wales; 2020. [cited 2021 Feb 28]. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

Council of Science Editors:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Doctoral Dissertation]. University of New South Wales; 2020. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations