Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for subject:(Testosterone Therapeutic use). Showing records 1 – 3 of 3 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of Hong Kong

1. Scarborough, Olivia Mary. Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials.

Degree: MPH, 2015, University of Hong Kong

Background The use of testosterone replacement therapy as treatment for clinical androgen deficiency has been growing in popularity. Low androgen levels are related to lower bone density in men, so testosterone might protect bone health. Bone mineral density is a biomarker for osteoporosis, which is associated with fractures. One systematic review and two previous meta-analyses have assessed the effect of testosterone replacement on bone health, one in 2005 and the other in 2006. This study provides an update focusing on the group who are increasingly using testosterone, i.e., older men. This study provides an up-to-date meta-analysis from randomized controlled trials of the effect of testosterone replacement on bone mineral density in middle-aged to older men. Methods A search of PubMed for randomized placebo-controlled trials was conducted until May of 2015, using the search term “(androgen OR testosterone) AND bone AND men AND trial” restricted to studies in English. A bibliographic search yielded no additional trials. Studies included in this meta-analysis were chosen using the following pre-specified inclusion and exclusion criteria. Trials were included if they were randomized, lasted at least 6 months, published before May of 2015, included men over 40 years with androgen deficiency, measured bone mineral density in g/cm3, and included at least one group given testosterone alone through oral, transdermal, or intramuscular means. Trials were excluded if they were not published in English or did not report adequate data for analysis. Quality of the studies was assessed using the Jadad scale. Sensitivity analysis was done excluding low quality studies. Meta-regression was performed on pre-determined subgroups based on testosterone dosage, duration of trials, baseline testosterone status, method of testosterone administration, and glucocorticoid use. Results The search of PubMed yielded 390 studies, of which 13 met the inclusion criteria. In an analysis of all studies, bone density of the lumbar spine increased by 0.023 g/cm3 (95% confidence interval (CI) 0.009 to 0.037) on testosterone, but bone mineral density of the femoral neck did not (0.006 g/〖cm〗3 (95% CI -0.001 to 0.013)). Heterogeneity across studies was high. Sensitivity analysis based on trials with a higher Jadad score gave a smaller effect of testosterone on lumbar spine bone density (0.014, 95% CI 0.0004 to 0.030) but the estimate for the femoral neck (0.008, 95% CI 0.0003 to 0.016) was slightly larger. Meta-regression showed method of testosterone administration explained a large amount of heterogeneity, and that intramuscular injections were associated with the largest increase in bone mineral density when compared to oral or transdermal testosterone. Conclusions This updated meta-analysis indicates that testosterone treatment has little effect on bone mineral density, especially after taking study quality into account. The conclusions of this study are greatly limited by the lack of fracture outcome. Given the very recent warnings…

Subjects/Keywords: Bones; Testosterone - Therapeutic use

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Scarborough, O. M. (2015). Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials. (Masters Thesis). University of Hong Kong. Retrieved from Scarborough, O. M.. (2015). Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5662758 ; http://hdl.handle.net/10722/221791

Chicago Manual of Style (16th Edition):

Scarborough, Olivia Mary. “Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials.” 2015. Masters Thesis, University of Hong Kong. Accessed August 18, 2019. Scarborough, O. M.. (2015). Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5662758 ; http://hdl.handle.net/10722/221791.

MLA Handbook (7th Edition):

Scarborough, Olivia Mary. “Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials.” 2015. Web. 18 Aug 2019.

Vancouver:

Scarborough OM. Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials. [Internet] [Masters thesis]. University of Hong Kong; 2015. [cited 2019 Aug 18]. Available from: Scarborough, O. M.. (2015). Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5662758 ; http://hdl.handle.net/10722/221791.

Council of Science Editors:

Scarborough OM. Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials. [Masters Thesis]. University of Hong Kong; 2015. Available from: Scarborough, O. M.. (2015). Effect of testosterone use on bone mineral density in men : a systematic review and meta-analysis of randomized controlled trials. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5662758 ; http://hdl.handle.net/10722/221791


Drexel University

2. Quinlan, Jr., John Andrew. Characterization of Testosterone-Loaded Polydimethylsiloxane Pellets for a Mouse Model of Metastatic Prostate Cancer.

Degree: 2019, Drexel University

Approximately one in six men are affected by prostate cancer, making it the most common cancer among men in the United States. For localized disease, the five-year survival rates are around 99%, however two out of every three patients that progress to metastatic disease will succumb to prostate cancer within five years. Androgens play a significant role in prostate cancer progression and biology and are a therapeutic target to slow metastatic progression. Most mouse models that are used to study prostate cancer do not incorporate changes in androgen level into the system. Here, we produce and characterize a silicone-based pellet loaded with testosterone optimized for use in a mouse model. The pellet provides slow release of bioactive testosterone in vitro and induces no cytotoxicity. Subcutaneously implanted in mice, the pellet provides elevated testosterone levels for two weeks, and surgical removal of the pellet causes serum testosterone levels to drop to castrate levels within two days. Importantly, the pellet induces minimal inflammation as observed histologically, meaning that the pellet can be implemented in a mouse model of metastatic prostate cancer without inducing the release of cytokines and other factors that may alter disease biology.

M.S., Biomedical Engineering  – Drexel University, 2019

Advisors/Committee Members: Fatatis, Alessandro, School of Biomedical Engineering, Science, and Health Systems.

Subjects/Keywords: Biomedical engineering; Drug delivery systems; Metastasis; Mice as laboratory animals; Polydimethylsiloxane; Testosterone – Therapeutic use

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Quinlan, Jr., J. A. (2019). Characterization of Testosterone-Loaded Polydimethylsiloxane Pellets for a Mouse Model of Metastatic Prostate Cancer. (Thesis). Drexel University. Retrieved from https://idea.library.drexel.edu/islandora/object/idea%3A9414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Quinlan, Jr., John Andrew. “Characterization of Testosterone-Loaded Polydimethylsiloxane Pellets for a Mouse Model of Metastatic Prostate Cancer.” 2019. Thesis, Drexel University. Accessed August 18, 2019. https://idea.library.drexel.edu/islandora/object/idea%3A9414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Quinlan, Jr., John Andrew. “Characterization of Testosterone-Loaded Polydimethylsiloxane Pellets for a Mouse Model of Metastatic Prostate Cancer.” 2019. Web. 18 Aug 2019.

Vancouver:

Quinlan, Jr. JA. Characterization of Testosterone-Loaded Polydimethylsiloxane Pellets for a Mouse Model of Metastatic Prostate Cancer. [Internet] [Thesis]. Drexel University; 2019. [cited 2019 Aug 18]. Available from: https://idea.library.drexel.edu/islandora/object/idea%3A9414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Quinlan, Jr. JA. Characterization of Testosterone-Loaded Polydimethylsiloxane Pellets for a Mouse Model of Metastatic Prostate Cancer. [Thesis]. Drexel University; 2019. Available from: https://idea.library.drexel.edu/islandora/object/idea%3A9414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Lopes, Eduardo José Andrade. "Análise da deficiência androgênica e terapia de reposição em homens idosos".

Degree: Mestrado, Urologia, 2004, University of São Paulo

A deficiência androgênica acomete um percentual de homens idosos ainda não bem definido na literatura. São usados parâmetros séricos hormonais de homens jovens, e apesar disto, a terapia de reposição da testosterona vem sendo defendida e utilizada largamente por muitos autores. Várias vias de reposição são usadas tentando simular o ciclo fisiológico de produção das testosteronas. Parece que a transdérmica é a que mais se aproxima do ideal. A relação câncer de próstata e testosterona é pouco compreendida. O receio do estímulo de um câncer oculto pela terapia de reposição não foi devidamente afastado. O tratamento deve ser instituído quando o quadro clínico e laboratorial for evidente.

The androgenic deficiency attacks a percentage of elderly men not well defined in literature yet. Hormonal serum parameters of young men are used and, in spite of that, the testosterone replacement therapy has been widely supported and used by many authors. Various ways of replacement are used trying to simulate the physiological cycle of the testosterone production. It seems that the transdermic is the one closest to the ideal. The relation of prostate cancer and testosterone is little understood. The fear of the stimulation of a concealed cancer by the replacement therapy has not been properly eliminated. The treatment should be indicated when the clinical and laboratorial was defined.

Advisors/Committee Members: Goes, Plinio Moreira de.

Subjects/Keywords: AGED; ANDRÓGENOS/deficiência; ANDROGENS/deficiency; HOMENS; HORMONE REPLACEMENT THERAPY/methods; IDOSO; MEN; TERAPIA DE REPOSIÇÃO HORMONAL/métodos; TESTOSTERONA/uso terapêutico; TESTOSTERONE/therapeutic use

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lopes, E. J. A. (2004). "Análise da deficiência androgênica e terapia de reposição em homens idosos". (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5153/tde-04082005-123116/ ;

Chicago Manual of Style (16th Edition):

Lopes, Eduardo José Andrade. “"Análise da deficiência androgênica e terapia de reposição em homens idosos".” 2004. Masters Thesis, University of São Paulo. Accessed August 18, 2019. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-04082005-123116/ ;.

MLA Handbook (7th Edition):

Lopes, Eduardo José Andrade. “"Análise da deficiência androgênica e terapia de reposição em homens idosos".” 2004. Web. 18 Aug 2019.

Vancouver:

Lopes EJA. "Análise da deficiência androgênica e terapia de reposição em homens idosos". [Internet] [Masters thesis]. University of São Paulo; 2004. [cited 2019 Aug 18]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5153/tde-04082005-123116/ ;.

Council of Science Editors:

Lopes EJA. "Análise da deficiência androgênica e terapia de reposição em homens idosos". [Masters Thesis]. University of São Paulo; 2004. Available from: http://www.teses.usp.br/teses/disponiveis/5/5153/tde-04082005-123116/ ;

.