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You searched for subject:(Synthetic Cathinone). Showing records 1 – 2 of 2 total matches.

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University of Newcastle

1. Williams, Michelle. Development of methods for the detection of novel psychoactive substances in oral fluid.

Degree: PhD, 2019, University of Newcastle

Research Doctorate - Doctor of Philosophy (PhD)

Novel psychoactive substances (NPS) are a group of drugs developed to evade legal and testing authorities whilst producing the effects similar to the drug they mimic. Two large groups of NPS are cathinones and synthetic cannabinoids. Due to the novel nature and rapid evolution of these drugs, testing options have not been available for workplaces wishing to undertake drug testing as part of their safety management program. The existing standards AS/NZS 4308:2008 and AS 4760:2006 only allow for the detection and quantitation of traditional drugs in urine and oral fluid respectively. This lack of any testing options for these novel substances, combined with fragmented exposure reports mean that capturing the scope and depth of the NPS problem in Australia is difficult. The specific aims of this PhD research were to: Promote a cohesive, national approach to reporting and documentation of exposures to novel psychoactive substances; Develop analytical methods for the detection of cathinones in oral fluid; Develop analytical methods for the detection of synthetic cannabinoids in oral fluid; Determine stability of novel psychoactive substances under varying conditions and time; Inform selection of collection devices by evaluating recovery from the Biophor and Quantisal devices. Collectively the methods developed in this Thesis allow for the analysis of a class of drug not previously detected by routine analysis along with advice on collection device. These methods have been adapted to a real-world situation and are established in a commercial pathology company. The ability to detect these drugs will assist in elucidating the scope of NPS use within Australia.

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: novel psychoactive substances; cathinone; synthetic cannabinoid; thesis by publication

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Williams, M. (2019). Development of methods for the detection of novel psychoactive substances in oral fluid. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1407512

Chicago Manual of Style (16th Edition):

Williams, Michelle. “Development of methods for the detection of novel psychoactive substances in oral fluid.” 2019. Doctoral Dissertation, University of Newcastle. Accessed August 08, 2020. http://hdl.handle.net/1959.13/1407512.

MLA Handbook (7th Edition):

Williams, Michelle. “Development of methods for the detection of novel psychoactive substances in oral fluid.” 2019. Web. 08 Aug 2020.

Vancouver:

Williams M. Development of methods for the detection of novel psychoactive substances in oral fluid. [Internet] [Doctoral dissertation]. University of Newcastle; 2019. [cited 2020 Aug 08]. Available from: http://hdl.handle.net/1959.13/1407512.

Council of Science Editors:

Williams M. Development of methods for the detection of novel psychoactive substances in oral fluid. [Doctoral Dissertation]. University of Newcastle; 2019. Available from: http://hdl.handle.net/1959.13/1407512


University of Illinois – Chicago

2. Jones, Shan Mei. Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection.

Degree: 2017, University of Illinois – Chicago

Microcrystal tests are a microchemistry technique developed in the 1800’s. Recently, they have been used more frequently in forensic science to help identify drugs of abuse, such as amphetamine and cocaine. Microcrystal tests are advantageous due to relatively short analysis time, small sample quantity used during test, and little to no sample preparation. Since microcrystal tests have only recently started to be used in forensic science again, validated methods are required, before they can be used. While microcrystal tests have been developed for many common drugs of abuse, newer drugs of abuse do not have validated tests, among which are the synthetic cathinones. Therefore, the purpose of this thesis was to develop microcrystal tests that could detect butylone, ethylone, and methylone, through optical characteristics of precipitated crystals. Synthetic cathinones, street name “Bath Salts”, are newer drugs of abuse that are man-made compounds similar to cathinone. They have become more prominent on the illegal drug market since 2010. Cathinone is a naturally occurring compound found in khat (Catha edulis) leaves. Since cathinone, and subsequently synthetic cathinones, is a stimulant, increased euphoria, alertness, sexual arousal, sociability, concentration, and motivation can occur upon administration. Since 2010, synthetic cathinones have become more prominent on the illegal drug market; signifying, validated microcrystal tests could be beneficial. Microcrystal tests were successfully developed to detect butylone, ethylone, and methylone individually and in the presence of adulterants. Each test utilized either pricrolonic or picric acid as the reagent. All three drugs were identified by precipitation of rosettes. Methylone formed rosettes with both reagents. All four crystals are distinguishable either by reagent used or optical properties. Also, attenuated total reflectance-infrared spectroscopy was performed on each drug and butylone and methylone crystals precipitated from picrolonic acid, for reference purposes. These tests are unique since no other drug is known to produce the same crystals and optical characteristics with these reagents; thus, they are good options for use in forensic science. Advisors/Committee Members: Larsen, Karl (advisor), Hall, Ashley (committee member), Schlemmer, Francis (committee member), King, Meggan (committee member), Larsen, Karl (chair).

Subjects/Keywords: Microcrystal; Microcrystal Test; Butylone; Ethylone; Methylone; Cathinone; Synthetic Cathinone; Bath Salts; Picrolonic Acid; Picric Acid; Microscopy; PLM; ATR

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jones, S. M. (2017). Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jones, Shan Mei. “Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection.” 2017. Thesis, University of Illinois – Chicago. Accessed August 08, 2020. http://hdl.handle.net/10027/22068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jones, Shan Mei. “Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection.” 2017. Web. 08 Aug 2020.

Vancouver:

Jones SM. Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2020 Aug 08]. Available from: http://hdl.handle.net/10027/22068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones SM. Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.