subject:(Synthetic )

Rice University

1. Zong, David Mao. Methods for Predicting Synthetic Gene Circuits.

Degree: PhD, Natural Sciences, 2020, Rice University

URL: http://hdl.handle.net/1911/108076

► Mature engineering disciplines use computational tools to test designs before they are built, which allows rapid engineering design-build-test cycles. Synthetic biology is an immature engineering… (more)

Subjects/Keywords: Synthetic Biology; Prediction

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zong, D. M. (2020). Methods for Predicting Synthetic Gene Circuits. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/108076

Chicago Manual of Style (16^th Edition):

Zong, David Mao. “Methods for Predicting Synthetic Gene Circuits.” 2020. Doctoral Dissertation, Rice University. Accessed April 10, 2021. http://hdl.handle.net/1911/108076.

MLA Handbook (7^th Edition):

Zong, David Mao. “Methods for Predicting Synthetic Gene Circuits.” 2020. Web. 10 Apr 2021.

Vancouver:

Zong DM. Methods for Predicting Synthetic Gene Circuits. [Internet] [Doctoral dissertation]. Rice University; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1911/108076.

Council of Science Editors:

Zong DM. Methods for Predicting Synthetic Gene Circuits. [Doctoral Dissertation]. Rice University; 2020. Available from: http://hdl.handle.net/1911/108076

2. Lu, Jia. Chinese Synthetic Word Analysis using Large-scale N-grams and An Extendable Lexicon Management System : 大規模なN-gramsデータを用いた中国語合成語解析及び拡張できる語彙管理システム; ダイキボナ N-grams データオモチイタチュウゴクゴゴウセイゴカイセキオヨビカクチョウデキルゴイカンリシステム.

Degree: Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/6288

Subjects/Keywords: synthetic word

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lu, J. (n.d.). Chinese Synthetic Word Analysis using Large-scale N-grams and An Extendable Lexicon Management System : 大規模なN-gramsデータを用いた中国語合成語解析及び拡張できる語彙管理システム; ダイキボナ N-grams データオモチイタチュウゴクゴゴウセイゴカイセキオヨビカクチョウデキルゴイカンリシステム. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/6288

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lu, Jia. “Chinese Synthetic Word Analysis using Large-scale N-grams and An Extendable Lexicon Management System : 大規模なN-gramsデータを用いた中国語合成語解析及び拡張できる語彙管理システム; ダイキボナ N-grams データオモチイタチュウゴクゴゴウセイゴカイセキオヨビカクチョウデキルゴイカンリシステム.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed April 10, 2021. http://hdl.handle.net/10061/6288.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lu, Jia. “Chinese Synthetic Word Analysis using Large-scale N-grams and An Extendable Lexicon Management System : 大規模なN-gramsデータを用いた中国語合成語解析及び拡張できる語彙管理システム; ダイキボナ N-grams データオモチイタチュウゴクゴゴウセイゴカイセキオヨビカクチョウデキルゴイカンリシステム.” Web. 10 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Lu J. Chinese Synthetic Word Analysis using Large-scale N-grams and An Extendable Lexicon Management System : 大規模なN-gramsデータを用いた中国語合成語解析及び拡張できる語彙管理システム; ダイキボナ N-grams データオモチイタチュウゴクゴゴウセイゴカイセキオヨビカクチョウデキルゴイカンリシステム. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10061/6288.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Lu J. Chinese Synthetic Word Analysis using Large-scale N-grams and An Extendable Lexicon Management System : 大規模なN-gramsデータを用いた中国語合成語解析及び拡張できる語彙管理システム; ダイキボナ N-grams データオモチイタチュウゴクゴゴウセイゴカイセキオヨビカクチョウデキルゴイカンリシステム. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/6288

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

3. 程, 飛. Using Large-scale unlabeled data for parsing internal structure of Chinese synthetic words : 大規模なラベル無しデータを用いて中国複合語の内部構造解析; ダイキボナラベルナシデータオモチイテチュウゴクフクゴウゴノナイブコウゾウカイセキ.

Degree: Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/8783

Subjects/Keywords: Synthetic word

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

程, �. (n.d.). Using Large-scale unlabeled data for parsing internal structure of Chinese synthetic words : 大規模なラベル無しデータを用いて中国複合語の内部構造解析; ダイキボナラベルナシデータオモチイテチュウゴクフクゴウゴノナイブコウゾウカイセキ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/8783

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

程, 飛. “Using Large-scale unlabeled data for parsing internal structure of Chinese synthetic words : 大規模なラベル無しデータを用いて中国複合語の内部構造解析; ダイキボナラベルナシデータオモチイテチュウゴクフクゴウゴノナイブコウゾウカイセキ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed April 10, 2021. http://hdl.handle.net/10061/8783.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

程, 飛. “Using Large-scale unlabeled data for parsing internal structure of Chinese synthetic words : 大規模なラベル無しデータを用いて中国複合語の内部構造解析; ダイキボナラベルナシデータオモチイテチュウゴクフクゴウゴノナイブコウゾウカイセキ.” Web. 10 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

程 �. Using Large-scale unlabeled data for parsing internal structure of Chinese synthetic words : 大規模なラベル無しデータを用いて中国複合語の内部構造解析; ダイキボナラベルナシデータオモチイテチュウゴクフクゴウゴノナイブコウゾウカイセキ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10061/8783.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

程 �. Using Large-scale unlabeled data for parsing internal structure of Chinese synthetic words : 大規模なラベル無しデータを用いて中国複合語の内部構造解析; ダイキボナラベルナシデータオモチイテチュウゴクフクゴウゴノナイブコウゾウカイセキ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/8783

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

4. Kashanna, J. Chemical modifications of parthenin and stereoselective total synthesis 3R 6E 1 7 BIS 4 Hydrozyphenyl HEPT6 ENE3 ol alongwith development of new synthetic methodologies;.

Degree: 2014, Osmania University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/27788

newline

Advisors/Committee Members: Biswanath Das.

Subjects/Keywords: Synthetic Methodologies

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kashanna, J. (2014). Chemical modifications of parthenin and stereoselective total synthesis 3R 6E 1 7 BIS 4 Hydrozyphenyl HEPT6 ENE3 ol alongwith development of new synthetic methodologies;. (Thesis). Osmania University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/27788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kashanna, J. “Chemical modifications of parthenin and stereoselective total synthesis 3R 6E 1 7 BIS 4 Hydrozyphenyl HEPT6 ENE3 ol alongwith development of new synthetic methodologies;.” 2014. Thesis, Osmania University. Accessed April 10, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/27788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kashanna, J. “Chemical modifications of parthenin and stereoselective total synthesis 3R 6E 1 7 BIS 4 Hydrozyphenyl HEPT6 ENE3 ol alongwith development of new synthetic methodologies;.” 2014. Web. 10 Apr 2021.

Vancouver:

Kashanna J. Chemical modifications of parthenin and stereoselective total synthesis 3R 6E 1 7 BIS 4 Hydrozyphenyl HEPT6 ENE3 ol alongwith development of new synthetic methodologies;. [Internet] [Thesis]. Osmania University; 2014. [cited 2021 Apr 10]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/27788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kashanna J. Chemical modifications of parthenin and stereoselective total synthesis 3R 6E 1 7 BIS 4 Hydrozyphenyl HEPT6 ENE3 ol alongwith development of new synthetic methodologies;. [Thesis]. Osmania University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/27788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

5. Hsiau, Timothy. Tools for engineering biology: methods for designing, building, and testing.

Degree: Bioengineering, 2013, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/1w32c0hq

► Genetic engineering remains a difficult task and the design, build, test cycle may take months or years to complete. Currently, all three aspects are laborious,… (more)

Subjects/Keywords: Molecular biology; synthetic biology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hsiau, T. (2013). Tools for engineering biology: methods for designing, building, and testing. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/1w32c0hq

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hsiau, Timothy. “Tools for engineering biology: methods for designing, building, and testing.” 2013. Thesis, University of California – Berkeley. Accessed April 10, 2021. http://www.escholarship.org/uc/item/1w32c0hq.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hsiau, Timothy. “Tools for engineering biology: methods for designing, building, and testing.” 2013. Web. 10 Apr 2021.

Vancouver:

Hsiau T. Tools for engineering biology: methods for designing, building, and testing. [Internet] [Thesis]. University of California – Berkeley; 2013. [cited 2021 Apr 10]. Available from: http://www.escholarship.org/uc/item/1w32c0hq.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsiau T. Tools for engineering biology: methods for designing, building, and testing. [Thesis]. University of California – Berkeley; 2013. Available from: http://www.escholarship.org/uc/item/1w32c0hq

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – San Diego

6. Miyake-Stoner, Shigeki Joseph. Engineering tumor-specific oncolytic adenoviruses with small molecule-controlled expanded tropisms.

Degree: Biology, 2016, University of California – San Diego

URL: http://www.escholarship.org/uc/item/7qg226zn

► A promising new strategy for cancer therapy is the use of engineered oncolytic viruses, adapted from their natural properties of seeking out and destroying cells… (more)

▼ A promising new strategy for cancer therapy is the use of engineered oncolytic viruses, adapted from their natural properties of seeking out and destroying cells to effectively find and specifically eliminate cancer cells. The overarching goal of the work presented here is to engineer powerful new adenoviruses that can preferentially infect tumor cells via disparate receptors, and replicate exclusively in cells that have lost tumor suppressor pathways.Since the creation of adenoviruses with novel tropism is limited by the ability to build and test new genetic designs, we desired targetable oncolytic adenoviruses with a modular platform that would enable rapid identification of new and controllable targeting moieties. We employed the property of rapamycin-induced FRB/FKBP heterodimerization to construct adenoviruses with chemically-controlled tropism by inserting FRB into the adenovirus and genetically encoding a functionalized FKBP fusion protein. We validated the targeting of this new class of viruses in culture using a panel of NCI breast cancer cell lines, targeting the frequently-upregulated cancer marker EGFR. We demonstrate that our targeting components are compatible with other virus modifications and that new adenoviruses with these mutations are able to infect and destroy a model of intractable triple negative breast cancer. Based on our findings, rapid discovery of effective targeting moieties for oncolytic adenoviruses should be possible, and we should avoid limiting the potency of future vectors by disrupting the highly evolved adenovirus capsid structure.While oncolytic adenoviruses have already shown to be safe in clinical trials, we have improved the replication specificity of an oncolytic virus based on the function of adenovirus genes that overlap with frequent tumor mutations. It has been shown that mutation in adenovirus E1A can prevent its inactivation of cell cycle-regulator retinoblastoma protein (Rb), and this mutation is the basis of selectivity for an oncolytic adenovirus in clinical trials. However, adenovirus also encodes E4orf6/7, which acts downstream of Rb by activating the cellular transcription factor E2F1 that also drives the cell cycle. We have combined mutations in E1A and E4orf6/7 and discovered highly selective oncolytic adenoviruses that have the promise to be the basis for safe and potent oncolytic cancer therapies.

Subjects/Keywords: Biology; Adenovirus; Cancer; Oncolytic; Synthetic

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Miyake-Stoner, S. J. (2016). Engineering tumor-specific oncolytic adenoviruses with small molecule-controlled expanded tropisms. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/7qg226zn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Miyake-Stoner, Shigeki Joseph. “Engineering tumor-specific oncolytic adenoviruses with small molecule-controlled expanded tropisms.” 2016. Thesis, University of California – San Diego. Accessed April 10, 2021. http://www.escholarship.org/uc/item/7qg226zn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Miyake-Stoner, Shigeki Joseph. “Engineering tumor-specific oncolytic adenoviruses with small molecule-controlled expanded tropisms.” 2016. Web. 10 Apr 2021.

Vancouver:

Miyake-Stoner SJ. Engineering tumor-specific oncolytic adenoviruses with small molecule-controlled expanded tropisms. [Internet] [Thesis]. University of California – San Diego; 2016. [cited 2021 Apr 10]. Available from: http://www.escholarship.org/uc/item/7qg226zn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Miyake-Stoner SJ. Engineering tumor-specific oncolytic adenoviruses with small molecule-controlled expanded tropisms. [Thesis]. University of California – San Diego; 2016. Available from: http://www.escholarship.org/uc/item/7qg226zn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

7. Huh, Jin Hang. Protein Delivery to Eukaryotic Cells by Engineered Bacteria.

Degree: Bioengineering, 2012, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/519059r3

► Synthetic biologists engineer genetic circuits for applications ranging from biosynthesis to biotherapeutics. Although the application of engineering strategies such as standardization, abstraction, and modularity has… (more)

▼ Synthetic biologists engineer genetic circuits for applications ranging from biosynthesis to biotherapeutics. Although the application of engineering strategies such as standardization, abstraction, and modularity has long been highlighted as the path to designing complex biological systems, early work generally relied on an ad hoc strategy, limiting applications to relatively simple systems. More recently, several groups have explicitly applied modular design to the development of biosynthetic pathways, biological computation, and increasingly sophisticated logic functions. However, connection of distinct functions to create a useful system-level behavior remains a key challenge. We assessed a possibility and limitation of a modular design when engineering a complex biological system. By applying a modular design, we engineered E. coli to deliver macromolecules to the cytoplasm of cancer cells in vitro. Fabrication, testing, composition, and troubleshooting of five functional modules produced an efficient system capable of delivering proteins to over 80 % of targeted cancer cells. The modular design strategy enabled facile system modification for both troubleshooting and optimization. These devices were then mixed and matched to build a new type of delivery device that enabled E. coli to escape from the vacuole and secrete payloads. The delivery system was then further modified to deliver payloads to other eukaryotic organisms. Successful application of modular design to the delivery system demonstrates that abstraction is a simple yet powerful tool for making the design of complex biological systems tractable. We expect that continued refinement of modular design, including incorporation of relevant quantitative information, will enable construction of increasingly complex systems. We envision that the bacterial delivery system developed here may itself become a high level module that can be incorporated into the design of more complex systems, such as a therapeutic bacterium delivering cancer-cell specific microRNA.

Subjects/Keywords: Biomedical engineering; Synthetic biology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huh, J. H. (2012). Protein Delivery to Eukaryotic Cells by Engineered Bacteria. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/519059r3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huh, Jin Hang. “Protein Delivery to Eukaryotic Cells by Engineered Bacteria.” 2012. Thesis, University of California – Berkeley. Accessed April 10, 2021. http://www.escholarship.org/uc/item/519059r3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huh, Jin Hang. “Protein Delivery to Eukaryotic Cells by Engineered Bacteria.” 2012. Web. 10 Apr 2021.

Vancouver:

Huh JH. Protein Delivery to Eukaryotic Cells by Engineered Bacteria. [Internet] [Thesis]. University of California – Berkeley; 2012. [cited 2021 Apr 10]. Available from: http://www.escholarship.org/uc/item/519059r3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huh JH. Protein Delivery to Eukaryotic Cells by Engineered Bacteria. [Thesis]. University of California – Berkeley; 2012. Available from: http://www.escholarship.org/uc/item/519059r3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rochester Institute of Technology

8. Brodsky, Kathy-Jo. The Synthesis and characterization of a BIS(4-(3-(4-Phenoxy)Propionitrile))-N,N'-disalicylidene-1,2-phenylenediamino)zirconium(IV),Zr(Nitrile)2 and the attempted sythesis of Zr(Amine)2 and coordination polymers contaning Zr(dspOH)2.

Degree: School of Chemistry and Materials Science (COS), 1994, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/6045

► The synthesis of a series of bis(quadridentate)zirconium(IV) complexes, that can be considered as derivatives of the model complex, bis(N,N'-disalicylidene-l,2-phenylenediaminozirconium (IV), Zr(dsp)2, was conducted in… (more)

Subjects/Keywords: Synthetic chemistry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brodsky, K. (1994). The Synthesis and characterization of a BIS(4-(3-(4-Phenoxy)Propionitrile))-N,N'-disalicylidene-1,2-phenylenediamino)zirconium(IV),Zr(Nitrile)2 and the attempted sythesis of Zr(Amine)2 and coordination polymers contaning Zr(dspOH)2. (Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/6045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brodsky, Kathy-Jo. “The Synthesis and characterization of a BIS(4-(3-(4-Phenoxy)Propionitrile))-N,N'-disalicylidene-1,2-phenylenediamino)zirconium(IV),Zr(Nitrile)2 and the attempted sythesis of Zr(Amine)2 and coordination polymers contaning Zr(dspOH)2.” 1994. Thesis, Rochester Institute of Technology. Accessed April 10, 2021. https://scholarworks.rit.edu/theses/6045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brodsky, Kathy-Jo. “The Synthesis and characterization of a BIS(4-(3-(4-Phenoxy)Propionitrile))-N,N'-disalicylidene-1,2-phenylenediamino)zirconium(IV),Zr(Nitrile)2 and the attempted sythesis of Zr(Amine)2 and coordination polymers contaning Zr(dspOH)2.” 1994. Web. 10 Apr 2021.

Vancouver:

Brodsky K. The Synthesis and characterization of a BIS(4-(3-(4-Phenoxy)Propionitrile))-N,N'-disalicylidene-1,2-phenylenediamino)zirconium(IV),Zr(Nitrile)2 and the attempted sythesis of Zr(Amine)2 and coordination polymers contaning Zr(dspOH)2. [Internet] [Thesis]. Rochester Institute of Technology; 1994. [cited 2021 Apr 10]. Available from: https://scholarworks.rit.edu/theses/6045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brodsky K. The Synthesis and characterization of a BIS(4-(3-(4-Phenoxy)Propionitrile))-N,N'-disalicylidene-1,2-phenylenediamino)zirconium(IV),Zr(Nitrile)2 and the attempted sythesis of Zr(Amine)2 and coordination polymers contaning Zr(dspOH)2. [Thesis]. Rochester Institute of Technology; 1994. Available from: https://scholarworks.rit.edu/theses/6045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

9. Takahashi, Melissa. Developing Design Principles For Engineering Rna Transcription Regulators And Rna Synthetic Gene Networks.

Degree: PhD, Chemical Engineering, 2015, Cornell University

URL: http://hdl.handle.net/1813/41135

► A major goal of synthetic biology is to reliably engineer microorganisms to perform a variety of functions with impact in the fields of biotechnology and… (more)

▼ A major goal of synthetic biology is to reliably engineer microorganisms to perform a variety of functions with impact in the fields of biotechnology and medicine. Cells naturally control their behavior and process information via genetic networks - webs of interactions between cellular regulatory molecules that ultimately control when specific genes are expressed. Therefore, the route that synthetic biologists have taken to engineer microorganisms has been through constructing synthetic gene networks. Historically, these networks were built using proteins that regulate transcription, but recently RNAs have emerged as versatile molecules that can be engineered to regulate all aspects of gene expression. Aside from their versatility, RNAs offer potential advantages over protein regulators for engineering synthetic gene networks. RNAs are relatively easy to engineer due to the direct relationship between their structure and function as well as the abundance of new technologies that allow us to determine RNA secondary structures. RNA regulators are typically compact in size making networks constructed out of them easier to build. Finally, RNA networks have the potential to propagate signals faster than protein networks due to their fast degradation rates. For these reasons the focus of the work presented here has been to develop new RNA transcription regulators and to lay the groundwork for using them to build RNA synthetic gene networks. Antisense RNA transcriptional attenuators (repressors) were shown to be a key component of the synthetic biology toolbox, with their ability to serve as building blocks for both signal integration logic networks and transcriptional cascades. However, in order to build more sophisticated networks, larger libraries of orthogonal attenuators that function independently are required. To address this bottleneck we developed a strategy to create chimeric fusions between the pT181 transcriptional attenuator and other natural antisense RNA translational regulators. This strategy resulted in a library of 7 orthogonal regulators. While the strategy was successful, many of the attenuators engineered during the process did not regulate gene expression. To help understand the relationship between the structure and function of these RNA regulators we characterized their structures using in-cell SHAPE-Seq and molecular dynamics simulations. In-cell SHAPE-Seq provides nucleotide-resolution chemical reactivity spectra for RNAs that reflect their structural state within the cell. By probing functional and non-functional regulators we uncovered a design principle that brings us closer to designing chimeric attenuators in silico, thus expanding the synthetic biology toolbox even further. Next, we expand the capabilities of RNAs by engineering small transcription activating RNAs (STARs). In order to build complex RNA synthetic gene networks the ability to both activate and repress gene expression is required. However, there are no known natural small RNA (sRNA) mechanisms that activate transcription. To… Advisors/Committee Members: Lucks,Julius (chair), Delisa,Matthew (committee member), Pollack,Lois (committee member).

Subjects/Keywords: RNA synthetic biology; transcription regulation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Takahashi, M. (2015). Developing Design Principles For Engineering Rna Transcription Regulators And Rna Synthetic Gene Networks. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/41135

Chicago Manual of Style (16^th Edition):

Takahashi, Melissa. “Developing Design Principles For Engineering Rna Transcription Regulators And Rna Synthetic Gene Networks.” 2015. Doctoral Dissertation, Cornell University. Accessed April 10, 2021. http://hdl.handle.net/1813/41135.

MLA Handbook (7^th Edition):

Takahashi, Melissa. “Developing Design Principles For Engineering Rna Transcription Regulators And Rna Synthetic Gene Networks.” 2015. Web. 10 Apr 2021.

Vancouver:

Takahashi M. Developing Design Principles For Engineering Rna Transcription Regulators And Rna Synthetic Gene Networks. [Internet] [Doctoral dissertation]. Cornell University; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1813/41135.

Council of Science Editors:

Takahashi M. Developing Design Principles For Engineering Rna Transcription Regulators And Rna Synthetic Gene Networks. [Doctoral Dissertation]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/41135

10. Vattikuti, Usha Rani. Synthetic investigations on Bisaryal Ureas, Bisphosphonates and Citalopram analogues as Pharmaceutically active Substances; -.

Degree: Chemistry, 2012, Jawaharlal Nehru Technological University, Hyderabad

URL: http://shodhganga.inflibnet.ac.in/handle/10603/19694

►

Nitrogen containing heterocyclic compounds are key building blocks used to develop compounds of biological or medicinal interest to chemists. A vast number of nitrogen containing… (more)

Subjects/Keywords: Bisaryal; Bisphosphonates; Investigations; Pharmaceutically; Synthetic

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vattikuti, U. R. (2012). Synthetic investigations on Bisaryal Ureas, Bisphosphonates and Citalopram analogues as Pharmaceutically active Substances; -. (Thesis). Jawaharlal Nehru Technological University, Hyderabad. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/19694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vattikuti, Usha Rani. “Synthetic investigations on Bisaryal Ureas, Bisphosphonates and Citalopram analogues as Pharmaceutically active Substances; -.” 2012. Thesis, Jawaharlal Nehru Technological University, Hyderabad. Accessed April 10, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/19694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vattikuti, Usha Rani. “Synthetic investigations on Bisaryal Ureas, Bisphosphonates and Citalopram analogues as Pharmaceutically active Substances; -.” 2012. Web. 10 Apr 2021.

Vancouver:

Vattikuti UR. Synthetic investigations on Bisaryal Ureas, Bisphosphonates and Citalopram analogues as Pharmaceutically active Substances; -. [Internet] [Thesis]. Jawaharlal Nehru Technological University, Hyderabad; 2012. [cited 2021 Apr 10]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/19694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vattikuti UR. Synthetic investigations on Bisaryal Ureas, Bisphosphonates and Citalopram analogues as Pharmaceutically active Substances; -. [Thesis]. Jawaharlal Nehru Technological University, Hyderabad; 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/19694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Rao, Lokeswara M. Development of New and Efficient Synthetic Methods for Ploglitazone, Ranolazine, Clopidogrel, Zafirlucast and Tadalafil; -.

Degree: Chemistry, 2013, Jawaharlal Nehru Technological University, Hyderabad

URL: http://shodhganga.inflibnet.ac.in/handle/10603/19311

►

Design and development of new, efficient and commercially viable synthetic methods for the preparation of active pharmaceutical newlineingredients is an integral part of the process… (more)

Subjects/Keywords: Ploglitazone; Ranolazine; Synthetic; Tadalafil; Zafirlucast

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rao, L. M. (2013). Development of New and Efficient Synthetic Methods for Ploglitazone, Ranolazine, Clopidogrel, Zafirlucast and Tadalafil; -. (Thesis). Jawaharlal Nehru Technological University, Hyderabad. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/19311

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rao, Lokeswara M. “Development of New and Efficient Synthetic Methods for Ploglitazone, Ranolazine, Clopidogrel, Zafirlucast and Tadalafil; -.” 2013. Thesis, Jawaharlal Nehru Technological University, Hyderabad. Accessed April 10, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/19311.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rao, Lokeswara M. “Development of New and Efficient Synthetic Methods for Ploglitazone, Ranolazine, Clopidogrel, Zafirlucast and Tadalafil; -.” 2013. Web. 10 Apr 2021.

Vancouver:

Rao LM. Development of New and Efficient Synthetic Methods for Ploglitazone, Ranolazine, Clopidogrel, Zafirlucast and Tadalafil; -. [Internet] [Thesis]. Jawaharlal Nehru Technological University, Hyderabad; 2013. [cited 2021 Apr 10]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/19311.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rao LM. Development of New and Efficient Synthetic Methods for Ploglitazone, Ranolazine, Clopidogrel, Zafirlucast and Tadalafil; -. [Thesis]. Jawaharlal Nehru Technological University, Hyderabad; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/19311

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Uday Kumar, Neelam. Development of new and imporved synthetic methods for few pharmaceutically active compounds and related substances; -.

Degree: Chemistry, 2014, Osmania University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/24276

None

-

Advisors/Committee Members: Rakeshwar, Bandichhor.

Subjects/Keywords: Synthetic Methods

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Uday Kumar, N. (2014). Development of new and imporved synthetic methods for few pharmaceutically active compounds and related substances; -. (Thesis). Osmania University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/24276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Uday Kumar, Neelam. “Development of new and imporved synthetic methods for few pharmaceutically active compounds and related substances; -.” 2014. Thesis, Osmania University. Accessed April 10, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/24276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Uday Kumar, Neelam. “Development of new and imporved synthetic methods for few pharmaceutically active compounds and related substances; -.” 2014. Web. 10 Apr 2021.

Vancouver:

Uday Kumar N. Development of new and imporved synthetic methods for few pharmaceutically active compounds and related substances; -. [Internet] [Thesis]. Osmania University; 2014. [cited 2021 Apr 10]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Uday Kumar N. Development of new and imporved synthetic methods for few pharmaceutically active compounds and related substances; -. [Thesis]. Osmania University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. SOFI BEAULA W. ANTIMICROBIAL ACTIVITY OF CATIONIC SYNTHETIC PEPTIDES;.

Degree: GENETICS, 2015, Sri Ramachandra University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/50665

►

Infections have been the major cause of disease throughout the history of human population The emergence of pathogenic bacterial resistance to available conventional antibiotics is… (more)

Subjects/Keywords: ANTIMICROBIAL ACTIVITY; CATIONIC SYNTHETIC PEPTIDES

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

W, S. B. (2015). ANTIMICROBIAL ACTIVITY OF CATIONIC SYNTHETIC PEPTIDES;. (Thesis). Sri Ramachandra University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/50665

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

W, SOFI BEAULA. “ANTIMICROBIAL ACTIVITY OF CATIONIC SYNTHETIC PEPTIDES;.” 2015. Thesis, Sri Ramachandra University. Accessed April 10, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/50665.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

W, SOFI BEAULA. “ANTIMICROBIAL ACTIVITY OF CATIONIC SYNTHETIC PEPTIDES;.” 2015. Web. 10 Apr 2021.

Vancouver:

W SB. ANTIMICROBIAL ACTIVITY OF CATIONIC SYNTHETIC PEPTIDES;. [Internet] [Thesis]. Sri Ramachandra University; 2015. [cited 2021 Apr 10]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/50665.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

W SB. ANTIMICROBIAL ACTIVITY OF CATIONIC SYNTHETIC PEPTIDES;. [Thesis]. Sri Ramachandra University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/50665

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

14. McFarlin, Rae. Chemoselective Functionalization of Carboxylic Acid and Phenol Containing Natural Products and the Development and Use of a Nucleophile Catalyzed Michael Aldol Lactonization Process.

Degree: MS, Chemistry, 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/149474

► The development of methods for site-selective derivatization of natural products to enable simultaneous arming and structure activity relationship (SAR) studies has shown great potential for… (more)

Subjects/Keywords: natural product functionalization; synthetic methodology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McFarlin, R. (2013). Chemoselective Functionalization of Carboxylic Acid and Phenol Containing Natural Products and the Development and Use of a Nucleophile Catalyzed Michael Aldol Lactonization Process. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/149474

Chicago Manual of Style (16^th Edition):

McFarlin, Rae. “Chemoselective Functionalization of Carboxylic Acid and Phenol Containing Natural Products and the Development and Use of a Nucleophile Catalyzed Michael Aldol Lactonization Process.” 2013. Masters Thesis, Texas A&M University. Accessed April 10, 2021. http://hdl.handle.net/1969.1/149474.

MLA Handbook (7^th Edition):

McFarlin, Rae. “Chemoselective Functionalization of Carboxylic Acid and Phenol Containing Natural Products and the Development and Use of a Nucleophile Catalyzed Michael Aldol Lactonization Process.” 2013. Web. 10 Apr 2021.

Vancouver:

McFarlin R. Chemoselective Functionalization of Carboxylic Acid and Phenol Containing Natural Products and the Development and Use of a Nucleophile Catalyzed Michael Aldol Lactonization Process. [Internet] [Masters thesis]. Texas A&M University; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1969.1/149474.

Council of Science Editors:

McFarlin R. Chemoselective Functionalization of Carboxylic Acid and Phenol Containing Natural Products and the Development and Use of a Nucleophile Catalyzed Michael Aldol Lactonization Process. [Masters Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/149474

University of Texas Southwestern Medical Center

15. Bayeh, Liela Antoinette. Synthetic Studies in the Selective Functionalization of Unsaturated Compounds: From Initial Applications in Medicinal Chemistry to General Applications in Unactivated Systems.

Degree: 2016, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/6135

► Medicinal chemistry and reaction development have influenced one another in the field of organic chemistry. The synthesis of therapeutic small molecules often requires the use… (more)

▼ Medicinal chemistry and reaction development have influenced one another in the field of organic chemistry. The synthesis of therapeutic small molecules often requires the use of practical synthetic methodologies, while reaction development is frequently inspired by the demands of medicinal chemistry. First the development of small molecule inhibitors of hypoxia inducible factors, which are heterodimeric transcription factors that have been implicated in a number of cancer environments, will be discussed. Two scaffolds have been designed and evaluated for their ability to selectively bind within the binding domain of the hypoxia inducible factor-2α isoform and inhibit heterodimerization, with the most potent agonist exhibiting a half maximal inhibitory concentration value of 23 nanomolar. Inspired by the stereospecific mode of action exhibited by the diaryl-tetrazolo-tetrahydropyrimidine-based scaffold of hypoxia inducible factor-2 antagonists, a potential co-catalyst system for the asymmetric synthesis of these derivatives has been identified, utilizing a synergistic combination of a cinchona alkaloid-based primary amine and acid catalysts. While the enantioselectivity of this reaction as it currently stands remains modest, these products can be isolated in up to 96:4 enantiomeric ratio through recrystallization efforts. Secondly, the development of a series of general and efficient methods for the synthesis of functionalized olefin products from simple unsaturated systems will be described. Unfunctionalized olefins and dienes are ideal substrates for chemical synthesis due to their low cost and ease of availability. However they present a variety of challenges when attempting to selectively differentiate between sterically and electronically similar carbon-hydrogen bonds. The processes described herein exploit the ability of sulfurimide and sulfurdiimide reagents to undergo hetero-ene reactions with terminal and internal olefins as well as [4+2] couplings with dienes. These reactions result in reactive intermediates that are utilized in a host of chemical transformations, including [2,3]-rearrangements to generate allylic amines and alcohols, Grignard coupling to generate linear and branched alkylated products, and aminoarylation chemistry. Most notably, a regio- diastereo- and enantioselective synthesis of multifunctional allylic sulfinimides from internal olefins is discussed. Advisors/Committee Members: Ready, Joseph M., Tambar, Uttam, De Brabander, Jef K., Chen, Chuo.

Subjects/Keywords: Alkenes; Catalysis; Chemistry Techniques, Synthetic

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bayeh, L. A. (2016). Synthetic Studies in the Selective Functionalization of Unsaturated Compounds: From Initial Applications in Medicinal Chemistry to General Applications in Unactivated Systems. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/6135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bayeh, Liela Antoinette. “Synthetic Studies in the Selective Functionalization of Unsaturated Compounds: From Initial Applications in Medicinal Chemistry to General Applications in Unactivated Systems.” 2016. Thesis, University of Texas Southwestern Medical Center. Accessed April 10, 2021. http://hdl.handle.net/2152.5/6135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bayeh, Liela Antoinette. “Synthetic Studies in the Selective Functionalization of Unsaturated Compounds: From Initial Applications in Medicinal Chemistry to General Applications in Unactivated Systems.” 2016. Web. 10 Apr 2021.

Vancouver:

Bayeh LA. Synthetic Studies in the Selective Functionalization of Unsaturated Compounds: From Initial Applications in Medicinal Chemistry to General Applications in Unactivated Systems. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2152.5/6135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bayeh LA. Synthetic Studies in the Selective Functionalization of Unsaturated Compounds: From Initial Applications in Medicinal Chemistry to General Applications in Unactivated Systems. [Thesis]. University of Texas Southwestern Medical Center; 2016. Available from: http://hdl.handle.net/2152.5/6135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

16. Lau, Esther. Generation of Human Synthetic Antibodies to Investigate the Biological Functions of the Receptor Tyrosine Kinases HER3 and PTK7.

Degree: 2013, University of Toronto

URL: http://hdl.handle.net/1807/70019

►

Receptor tyrosine kinases or RTKs are an important class of signaling proteins that are frequently deregulated in cancer and other diseases. Based on a series… (more)

Subjects/Keywords: HER3; PTK7; synthetic antibodies; cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lau, E. (2013). Generation of Human Synthetic Antibodies to Investigate the Biological Functions of the Receptor Tyrosine Kinases HER3 and PTK7. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70019

Chicago Manual of Style (16^th Edition):

Lau, Esther. “Generation of Human Synthetic Antibodies to Investigate the Biological Functions of the Receptor Tyrosine Kinases HER3 and PTK7.” 2013. Masters Thesis, University of Toronto. Accessed April 10, 2021. http://hdl.handle.net/1807/70019.

MLA Handbook (7^th Edition):

Lau, Esther. “Generation of Human Synthetic Antibodies to Investigate the Biological Functions of the Receptor Tyrosine Kinases HER3 and PTK7.” 2013. Web. 10 Apr 2021.

Vancouver:

Lau E. Generation of Human Synthetic Antibodies to Investigate the Biological Functions of the Receptor Tyrosine Kinases HER3 and PTK7. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1807/70019.

Council of Science Editors:

Lau E. Generation of Human Synthetic Antibodies to Investigate the Biological Functions of the Receptor Tyrosine Kinases HER3 and PTK7. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/70019

Universidade Nova

17. Nunes, Diogo André Pereira Alves. Differences in the prices of physical ETF’s and synthetic ETF’s.

Degree: 2013, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9846

►

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Finance from the NOVA – School of Business… (more)

Subjects/Keywords: Pricing; Volatility; Physical; Synthetic

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nunes, D. A. P. A. (2013). Differences in the prices of physical ETF’s and synthetic ETF’s. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nunes, Diogo André Pereira Alves. “Differences in the prices of physical ETF’s and synthetic ETF’s.” 2013. Thesis, Universidade Nova. Accessed April 10, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nunes, Diogo André Pereira Alves. “Differences in the prices of physical ETF’s and synthetic ETF’s.” 2013. Web. 10 Apr 2021.

Vancouver:

Nunes DAPA. Differences in the prices of physical ETF’s and synthetic ETF’s. [Internet] [Thesis]. Universidade Nova; 2013. [cited 2021 Apr 10]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nunes DAPA. Differences in the prices of physical ETF’s and synthetic ETF’s. [Thesis]. Universidade Nova; 2013. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

18. Fortune, Susan Houston. Selected "Rovana" (saran), "Verel" (modacrylic), and rayon blend drapery fabrics evaluated by laboratory tests for resistance to light, laundering, abrasion, stress and fire.

Degree: MS, Clothing, Textiles and Related Arts, 1965, Oregon State University

URL: http://hdl.handle.net/1957/48284

► Thirteen fabrics containing "Rovana" (saran), "Verel" (mod-acrylic), and rayon were examined for colorfastness to light and laundering, shrinkage, tensile strength, elongation, abrasion-resistance and flammability. The… (more)

▼ Thirteen fabrics containing "Rovana" (saran), "Verel" (mod-acrylic), and rayon were examined for colorfastness to light and laundering, shrinkage, tensile strength, elongation, abrasion-resistance and flammability. The fabrics represented three weaves: plain, twill and leno; and three colors: white, eggshell and turquoise. The fiber contents, according to the manufacturers, varied from 20 percent "Rovana", 56 percent "Verel" and 24 percent rayon to 49.3 "Rovana", 30.5 percent "Verel" and 20.2 percent rayon. Chemical analysis revealed that all of the fabrics varied from the manufacturers' stated fiber contents. A Fade-Ometer was used to test for colorfastness to light. Although no fading was visible to the eye, the plain weave fabrics of high "Rovana" content showed the greatest color change according to a Gardner Color Difference Meter. White fabrics and broken twill weave fabrics were modified also. Washing had little effect on the colors. Shrinkage was most pronounced in the filling direction and was due chiefly to laundering. Fabrics fabricated in a broken twill weave of approximately 30 percent "Rovana" exhibited slightly more shrinkage than the four percent allowance recommended by the American Hotel Association. The remaining fabrics shrank only approximately one percent. Fabrics appeared to be most affected by 63.5°C temperatures in an oven during the first 50 hours according to a heat study which measured shrinkage and tensile strength, but generally the effect was slight. There was considerable variation in tensile strength of the filling yarns but the percentage retained after Fade-Ometer exposure and launderings was good. The "Rovana" warp yarns were slightly less strong but retained more strength. Fabrics of high "Verel" content showed the greatest elongation in the filling direction and fabrics of high "Rovana" in the warp direction. Loss of body was noticed as a result of abrasion, with loose weaves and fabrics of high "Rovana" content being affected the most. All of the fabrics proved to be flame-resistant as they would not support combustion. As a result of this study, these fabrics, particularly the plain weave fabrics containing 30 percent "Rovana", 50 percent "Verel" and 20 percent rayon, are recommended for home and institutional use. Advisors/Committee Members: Bubl, Janet L. (advisor).

Subjects/Keywords: Synthetic fabrics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fortune, S. H. (1965). Selected "Rovana" (saran), "Verel" (modacrylic), and rayon blend drapery fabrics evaluated by laboratory tests for resistance to light, laundering, abrasion, stress and fire. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/48284

Chicago Manual of Style (16^th Edition):

Fortune, Susan Houston. “Selected "Rovana" (saran), "Verel" (modacrylic), and rayon blend drapery fabrics evaluated by laboratory tests for resistance to light, laundering, abrasion, stress and fire.” 1965. Masters Thesis, Oregon State University. Accessed April 10, 2021. http://hdl.handle.net/1957/48284.

MLA Handbook (7^th Edition):

Fortune, Susan Houston. “Selected "Rovana" (saran), "Verel" (modacrylic), and rayon blend drapery fabrics evaluated by laboratory tests for resistance to light, laundering, abrasion, stress and fire.” 1965. Web. 10 Apr 2021.

Vancouver:

Fortune SH. Selected "Rovana" (saran), "Verel" (modacrylic), and rayon blend drapery fabrics evaluated by laboratory tests for resistance to light, laundering, abrasion, stress and fire. [Internet] [Masters thesis]. Oregon State University; 1965. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1957/48284.

Council of Science Editors:

Fortune SH. Selected "Rovana" (saran), "Verel" (modacrylic), and rayon blend drapery fabrics evaluated by laboratory tests for resistance to light, laundering, abrasion, stress and fire. [Masters Thesis]. Oregon State University; 1965. Available from: http://hdl.handle.net/1957/48284

Oregon State University

19. Duncan, Anne Elaine. Performance characteristics of a soil-release finish on polyester knit fabrics.

Degree: MS, Clothing, Textiles and Related Arts, 1974, Oregon State University

URL: http://hdl.handle.net/1957/44345

► The main objectives of this study were to determine if the manufacturer's claims for a soil-release-finished fabric were true and to determine if the finished… (more)

▼ The main objectives of this study were to determine if the manufacturer's claims for a soil-release-finished fabric were true and to determine if the finished fabrics were satisfactory from the consumers' point of view. Differently colored (white, blue and yellow) blouses constructed from soil-release-finished polyester knit fabrics and comparable unfinished polyester knit fabrics were worn by six women for 24 wearings each. For comparison purposes, test specimens cut from each fabric were laundered but not worn, and test specimens were neither worn nor laundered, but were used as controls. The participants in the wear study found that the soil-release-finished blouses were more comfortable to wear in terms of temperature and water-carrying properties than the unfinished blouses. The white test specimens after 24 launderings had the greatest change in color as perceived by consumers. Reflectance readings found this to hold true for the soil-release-finished fabrics, but showed that the greatest change in color for the unfinished fabrics occurred with the color yellow. The greatest change in color for the blouses as perceived by consumers was for the color blue. This was consistent with the reflectance readings. Consumers would accept a change in color if it were uniform within the garment more readily than they would if the two pieces were in one garment. From reflectance readings it was found that there was a difference in color on the original fabrics due to the soil-release finish. There were indications that the soil-release-finished blouses had a greater tendency to pill than the unfinished blouses. Consumers rated the blouses made from the soil-releasefinished fabrics as having better soil-release than the unfinished blouses. Artificially soiled soil-release-finished specimens had considerably less soil build-up after laundering than the unfinished sample. There was no soil redeposited during laundering on the soilrelease- finished fabric. There was a loss of durable press appearance due to the soilrelease finish. Residual shrinkage occurred through the entire 24 launderings with the exception of the white fabrics (warp knit construction) in the course direction. The amount of dimensional change would be considered acceptable for all fabrics tested. From electron micrographs, distinct differences in the surfaces of the unfinished and soil-release-finished fibers were found. The soil-release-finished fibers had very etched surfaces compared to smooth surfaces for the unfinished fibers. Based upon the findings of this study it can be concluded that the soil-release-finished polyester knit fabrics would be acceptable from the consumers' point of view. Advisors/Committee Members: Bubl, Janet L. (advisor).

Subjects/Keywords: Synthetic fabrics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Duncan, A. E. (1974). Performance characteristics of a soil-release finish on polyester knit fabrics. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/44345

Chicago Manual of Style (16^th Edition):

Duncan, Anne Elaine. “Performance characteristics of a soil-release finish on polyester knit fabrics.” 1974. Masters Thesis, Oregon State University. Accessed April 10, 2021. http://hdl.handle.net/1957/44345.

MLA Handbook (7^th Edition):

Duncan, Anne Elaine. “Performance characteristics of a soil-release finish on polyester knit fabrics.” 1974. Web. 10 Apr 2021.

Vancouver:

Duncan AE. Performance characteristics of a soil-release finish on polyester knit fabrics. [Internet] [Masters thesis]. Oregon State University; 1974. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1957/44345.

Council of Science Editors:

Duncan AE. Performance characteristics of a soil-release finish on polyester knit fabrics. [Masters Thesis]. Oregon State University; 1974. Available from: http://hdl.handle.net/1957/44345

Columbia University

20. Cho, Eunsung. The Thread of Juche: Vinalon and Materially-Embodied Interdependencies in North Korea, 1930-2018.

Degree: 2020, Columbia University

URL: https://doi.org/10.7916/d8-6hmb-ew26

► This dissertation examines how North Korea’s version of nationalism was constructed by taking a material thing as my point of departure. Vinalon is a kind… (more)

▼ This dissertation examines how North Korea’s version of nationalism was constructed by taking a material thing as my point of departure. Vinalon is a kind of synthetic fiber developed by a Korean scientist during the Japanese colonial era. North Korea succeeded in the industrial production of vinalon in 1961. The construction of the Vinalon Factory in Hamhŭng was completed by North Koreans using their own resources and manpower. Unlike nylon, which uses oil as the main raw material, vinalon uses locally-mined anthracite and limestone as the main raw materials. For these reasons, North Korea was proud of the industrialization of vinalon, eventually giving it the title of “Juche [self-reliance] fiber.” Although North Korea emphasizes solely its self-reliant aspect, vinalon has had a global history from the colonial period to the post-war era. I argue that the global network of technological knowledge made the industrial production of vinalon possible and that the industrialization of vinalon was a historically contingent process of experimentation. Uncovering the global history behind the industrialization of vinalon and probing vinalon as a material produced in the dynamics between Juche and the global, my work contributes to the rethinking of U.S.-Soviet-centered Cold War scholarship by investigating Second World-Second World and Second World-Third World relationships. Furthermore, focusing on the agency of the vinalon products in people’s everyday lives, my project explores how vinalon threaded North Korea’s Juche discourse through a variety of products that penetrated into the everyday and the gendering of those products. By analyzing the interaction between the scientific and the socio-political realms on the one hand and by exploring how the Mother Party discourse became embodied in the form of the material vinalon on the other hand, my dissertation goes beyond the politics-centered narrative that has dominated scholarly work on North Korean ideology. In this dissertation, I utilize diverse sets of textual, material, and visual sources, as well as interviews, while combining methods from social and global history, material culture studies, history of science and technology, gender studies, and STS studies. Each chapter of the dissertation explores different aspects of the social life of vinalon in North Korea. Chapter 1 investigates how the industrialization of vinalon allowed North Korea to promote its legitimacy as a postcolonial independent nation-state while contributing to the expansion of the Juche discourse, providing background on the processes through which vinalon was invented and industrialized. This chapter shows that the successful industrialization of vinalon and subsequent fetishization of Juche science facilitated the formulation of Juche ideology in middle to late 1960s North Korea. Chapter 2 uncovers the global history that enabled vinalon to be industrialized, focusing on the global circulation of technological knowledge from the colonial period to the 1960s. This chapter also traces…

Subjects/Keywords: Synthetic fabrics; Nationalism; History

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cho, E. (2020). The Thread of Juche: Vinalon and Materially-Embodied Interdependencies in North Korea, 1930-2018. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-6hmb-ew26

Chicago Manual of Style (16^th Edition):

Cho, Eunsung. “The Thread of Juche: Vinalon and Materially-Embodied Interdependencies in North Korea, 1930-2018.” 2020. Doctoral Dissertation, Columbia University. Accessed April 10, 2021. https://doi.org/10.7916/d8-6hmb-ew26.

MLA Handbook (7^th Edition):

Cho, Eunsung. “The Thread of Juche: Vinalon and Materially-Embodied Interdependencies in North Korea, 1930-2018.” 2020. Web. 10 Apr 2021.

Vancouver:

Cho E. The Thread of Juche: Vinalon and Materially-Embodied Interdependencies in North Korea, 1930-2018. [Internet] [Doctoral dissertation]. Columbia University; 2020. [cited 2021 Apr 10]. Available from: https://doi.org/10.7916/d8-6hmb-ew26.

Council of Science Editors:

Cho E. The Thread of Juche: Vinalon and Materially-Embodied Interdependencies in North Korea, 1930-2018. [Doctoral Dissertation]. Columbia University; 2020. Available from: https://doi.org/10.7916/d8-6hmb-ew26

University of Ottawa

21. Roney, Ian James. Construction and Optimization of Tetracycline-Responsive Gene Expression Systems .

Degree: 2016, University of Ottawa

URL: http://hdl.handle.net/10393/35058

► Conditional gene expression systems that enable inducible and reversible transcriptional control are essential research tools and have broad applications in biomedicine and biotechnology. The reverse… (more)

Subjects/Keywords: Synthetic Biology; Gene Expression Systems

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roney, I. J. (2016). Construction and Optimization of Tetracycline-Responsive Gene Expression Systems . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/35058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Roney, Ian James. “Construction and Optimization of Tetracycline-Responsive Gene Expression Systems .” 2016. Thesis, University of Ottawa. Accessed April 10, 2021. http://hdl.handle.net/10393/35058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Roney, Ian James. “Construction and Optimization of Tetracycline-Responsive Gene Expression Systems .” 2016. Web. 10 Apr 2021.

Vancouver:

Roney IJ. Construction and Optimization of Tetracycline-Responsive Gene Expression Systems . [Internet] [Thesis]. University of Ottawa; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10393/35058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roney IJ. Construction and Optimization of Tetracycline-Responsive Gene Expression Systems . [Thesis]. University of Ottawa; 2016. Available from: http://hdl.handle.net/10393/35058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

22. Homme, Paige. Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/89425

►

Guiding appropriate medical treatment and population surveillance are examples of the crucial functions of diagnostics in health care [1]. Antibody based assays are routinely employed,… (more)

Subjects/Keywords: Diagnostics; Synthetic biology; Yeast; 0202

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Homme, P. (2017). Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/89425

Chicago Manual of Style (16^th Edition):

Homme, Paige. “Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris.” 2017. Masters Thesis, University of Toronto. Accessed April 10, 2021. http://hdl.handle.net/1807/89425.

MLA Handbook (7^th Edition):

Homme, Paige. “Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris.” 2017. Web. 10 Apr 2021.

Vancouver:

Homme P. Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1807/89425.

Council of Science Editors:

Homme P. Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/89425

University of Toronto

23. Homme, Paige. Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/96003

►

Guiding appropriate medical treatment and population surveillance are examples of the crucial functions of diagnostics in health care [1]. Antibody based assays are routinely employed,… (more)

Subjects/Keywords: Diagnostics; Synthetic biology; Yeast; 0202

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Homme, P. (2017). Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/96003

Chicago Manual of Style (16^th Edition):

Homme, Paige. “Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris.” 2017. Masters Thesis, University of Toronto. Accessed April 10, 2021. http://hdl.handle.net/1807/96003.

MLA Handbook (7^th Edition):

Homme, Paige. “Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris.” 2017. Web. 10 Apr 2021.

Vancouver:

Homme P. Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1807/96003.

Council of Science Editors:

Homme P. Whole-cell regenerating 'microbead' to capture disease antibodies using the yeast species, Pichia pastoris. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/96003

AUT University

24. Tovic, Irena. The multiplicity of “I” .

Degree: 2012, AUT University

URL: http://hdl.handle.net/10292/4617

► The Rain of the Praying Mantis is an exploration, a journey, into the life of Kataryna who returns to a place which she loves and… (more)

Subjects/Keywords: Synthetic prose; Protagonist’s personal reflections

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tovic, I. (2012). The multiplicity of “I” . (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/4617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tovic, Irena. “The multiplicity of “I” .” 2012. Thesis, AUT University. Accessed April 10, 2021. http://hdl.handle.net/10292/4617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tovic, Irena. “The multiplicity of “I” .” 2012. Web. 10 Apr 2021.

Vancouver:

Tovic I. The multiplicity of “I” . [Internet] [Thesis]. AUT University; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10292/4617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tovic I. The multiplicity of “I” . [Thesis]. AUT University; 2012. Available from: http://hdl.handle.net/10292/4617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

25. Mowatt, Heather Gray. Different extraction efficiencies observed from synthetic cannabinoid analysis due to burning and matrix effects.

Degree: MS, Biomedical Forensic Sciences, 2013, Boston University

URL: http://hdl.handle.net/2144/17139

► Cannabinoids are compounds that are naturally present in Cannabis sativa L., which interact with cannabinoid receptors in the nervous system, known as CB1 and CB2… (more)

▼ Cannabinoids are compounds that are naturally present in Cannabis sativa L., which interact with cannabinoid receptors in the nervous system, known as CB1 and CB2 receptors. The most abundant and well-known cannabinoid that can be isolated from cannabis is 9-tetrahydrocannabinol (THC). The structure of this compound specifically allows interaction with the CB1 and CB2 receptors, known as cannabimimetic activity. Other compounds have since been produced, inspired by THC, which have been designed to elicit similar pharmacological responses, and therefore are beneficial as analgesics. These compounds are known as synthetic cannabinoids. Synthetic cannabinoids, while potentially useful as therapeutic treatments for pain, are currently also popular as recreational drugs. Herbal products that contain synthetic cannabinoids are sold as “legal highs,” as few of these compounds are illegal according to the Controlled Drugs and Substances Act. These products are prepared by combining synthetic cannabinoids and plant material, and are smoked similar to marijuana. As the legality of many synthetic cannabinoids is quickly decreasing, as evidenced by the March 2011 emergency scheduling of five such compounds, it is becoming increasingly likely that these products will soon become popular exhibits to be submitted to controlled substances laboratories for testing. If a previously smoked product is submitted, there could potentially be effects due to the burning, the presence of the plant or paper substrate, and other synthetic cannabinoids that could directly diminish the facility of analysis. The aim of this thesis was to investigate these effects using four synthetic cannabinoids (AM-2201, JWH-015, HU-211, and RCS-4) and four substrates (tobacco, rolling paper, mint, and rosemary). Results demonstrated diminished peak areas, which are likely due to the introduction of these variables, which include burning the drug of abuse, and spiking the drug of abuse onto various matrices. The trend of lower peak areas further suggests that burning, the presence of plant material, and other cannabinoids potentially all compromise the facility of analyzing synthetic cannabinoid products. The act of burning one synthetic cannabinoid in particular, AM-2201, appeared to greatly decrease the capability to detect the analyte, as did the application of AM-2201 to various substrates. Furthermore, the ability to detect AM-2201 appeared to vary greatly between results obtained from analyzing samples applied to different substrates. Analysis of cannabinoid mixtures demonstrated that GC/MS analysis of different cannabinoids gave various peak areas although the concentrations remained consistent. Peak area ratios of cannabinoid mixtures that were extracted from substrates were found to not differ significantly between the specific substrates studied. This research supports that all of these variables should therefore be considered in regards to analysis of herbal products containing synthetic cannabinoids.

Subjects/Keywords: Synthetic cannabinoids; Extraction efficiencies

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mowatt, H. G. (2013). Different extraction efficiencies observed from synthetic cannabinoid analysis due to burning and matrix effects. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/17139

Chicago Manual of Style (16^th Edition):

Mowatt, Heather Gray. “Different extraction efficiencies observed from synthetic cannabinoid analysis due to burning and matrix effects.” 2013. Masters Thesis, Boston University. Accessed April 10, 2021. http://hdl.handle.net/2144/17139.

MLA Handbook (7^th Edition):

Mowatt, Heather Gray. “Different extraction efficiencies observed from synthetic cannabinoid analysis due to burning and matrix effects.” 2013. Web. 10 Apr 2021.

Vancouver:

Mowatt HG. Different extraction efficiencies observed from synthetic cannabinoid analysis due to burning and matrix effects. [Internet] [Masters thesis]. Boston University; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2144/17139.

Council of Science Editors:

Mowatt HG. Different extraction efficiencies observed from synthetic cannabinoid analysis due to burning and matrix effects. [Masters Thesis]. Boston University; 2013. Available from: http://hdl.handle.net/2144/17139

Columbia University

26. Ostrov, Nili. Expanding Biological Engineering from Single Enzymes to Cellular Pathways.

Degree: 2012, Columbia University

URL: https://doi.org/10.7916/D8M043GN

► The emerging field of synthetic biology evolved from biological research much the same way synthetic chemistry evolved from chemical research; with accumulated knowledge of the… (more)

Subjects/Keywords: Synthetic biology; Genetics; Microbiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ostrov, N. (2012). Expanding Biological Engineering from Single Enzymes to Cellular Pathways. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8M043GN

Chicago Manual of Style (16^th Edition):

Ostrov, Nili. “Expanding Biological Engineering from Single Enzymes to Cellular Pathways.” 2012. Doctoral Dissertation, Columbia University. Accessed April 10, 2021. https://doi.org/10.7916/D8M043GN.

MLA Handbook (7^th Edition):

Ostrov, Nili. “Expanding Biological Engineering from Single Enzymes to Cellular Pathways.” 2012. Web. 10 Apr 2021.

Vancouver:

Ostrov N. Expanding Biological Engineering from Single Enzymes to Cellular Pathways. [Internet] [Doctoral dissertation]. Columbia University; 2012. [cited 2021 Apr 10]. Available from: https://doi.org/10.7916/D8M043GN.

Council of Science Editors:

Ostrov N. Expanding Biological Engineering from Single Enzymes to Cellular Pathways. [Doctoral Dissertation]. Columbia University; 2012. Available from: https://doi.org/10.7916/D8M043GN

Boston University

27. Ward, Jessamyn. Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines.

Degree: MS, Biomedical Forensic Sciences, 2017, Boston University

URL: http://hdl.handle.net/2144/26942

► Designer drugs are some of the most commonly abused substances in the world. They are synthesized through slight chemical modifications of existing substances, evading the… (more)

▼ Designer drugs are some of the most commonly abused substances in the world. They are synthesized through slight chemical modifications of existing substances, evading the law while maintaining the desired effects of the pharmaceutical or illicit substance. These drugs are often marketed as “herbal” or “natural,” but are fully synthetic. Due to their constant, rapid emergence, there is a need for a rapid method of identification, both in the field as well as in the laboratory. One group of these designer drugs are synthetic piperazines. Named for the piperazine ring found in their chemical structures, synthetic piperazines are central nervous system stimulants that have the reputation of mimicking the psychoactive effects of the illicit compounds amphetamine and 3, 4-methylenedioxymethampetamine (MDMA). Over the past 10 years, synthetic piperazine cases submitted to forensic laboratories in the United States have greatly increased, including a 30-fold increase between 2007 and 2009 alone. Surface enhanced Raman spectroscopy (SERS) was investigated as a method for the rapid qualitative analysis of synthetic piperazines. SERS is a type of vibrational spectroscopy, which utilizes the interaction of light and matter to elucidate details of the chemical structure of a molecule. SERS combines laser spectroscopy with the optical properties of metallic nanostructures, resulting in strongly enhanced signals from the Raman scattering of light. Each chemical structure will give a unique SERS spectrum and this, coupled with the minimal-to-no sample preparation and the portability of a SERS instrument, makes SERS a strong candidate for the identification of not only synthetic piperazines, but all designer drugs. To evaluate the use of SERS for the qualitative analysis of synthetic piperazines, eight synthetic piperazines were adsorbed onto a SERS substrate. The interaction with the gold nanoparticles enhanced the Raman scattering for all eight of the synthetic piperazines and SERS spectra were obtained. All eight drugs were found to give a robust and reproducible signal, requiring a fewer number of scans, less laser power, and less time for analysis compared with traditional Raman spectroscopy. When compared with traditional Raman spectra, the synthetic piperazines demonstrated sensitivity enhancement factors of up to 10⁸ using SERS. A partial least squares-discriminant analysis (PLS-DA) statistical model was built and used to evaluate the analytical sensitivity and specificity of the SERS method. The PLS-DA model helped determine a limit of detection of 10 μg/mL of BZP. All eight synthetic piperazines could be identified by the statistical model below an error rate of 20% when compared to each other- a strong indication of a method with high specificity.Through this research, it has been demonstrated that SERS can be applied efficiently as a qualitative technique for the analysis of synthetic piperazines.

Subjects/Keywords: Chemistry; SERS; Synthetic piperazines

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ward, J. (2017). Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/26942

Chicago Manual of Style (16^th Edition):

Ward, Jessamyn. “Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines.” 2017. Masters Thesis, Boston University. Accessed April 10, 2021. http://hdl.handle.net/2144/26942.

MLA Handbook (7^th Edition):

Ward, Jessamyn. “Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines.” 2017. Web. 10 Apr 2021.

Vancouver:

Ward J. Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2144/26942.

Council of Science Editors:

Ward J. Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/26942

University of Oxford

28. Spratt, Joel. DNA-templated assembly of the bacterial flagellar motor's cytoplasmic ring.

Degree: PhD, 2018, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:27428b51-4fb8-4964-95b6-d3cbb5db996d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770682

► The bacterial flagellar motor is one of the most complex protein machines found in nature and how it self-assembles and produces force are very much… (more)

▼ The bacterial flagellar motor is one of the most complex protein machines found in nature and how it self-assembles and produces force are very much open questions. In this thesis, I study the constituent parts of the motor in vitro, with the focus being primarily on FliG, a protein which helps to form the motor's cytoplasmic ring. The experimental approach employs a DNA scaffold to direct the in vitro formation of the FliG ring, with the aim of determining both the number of proteins in the complex and the means by which they associate to form a circular structure. One leading theory states that the FliG proteins interact through a process of domain-swap oligomerization and the primary goal of this work is to search for evidence of this process with the aid of in vitro DNA templates. To attach the FliG protein to the underlying DNA structures, I produced FliG-DNA conjugates through two different means. First, I bound both tris- and pentakis-NTA-modified DNA strands to the Histidine-tag of FliG and showed that these conjugates could be arranged on simple, linear DNA templates. In order for the proteins to be arranged with the spacing observed in the cytoplasmic ring however, a different conjugation strategy was required in which a maleimide-modified DNA strand was reacted with a single-cysteine FliG mutant. After issues relating to Histidine-tag-mediated FliG dimerization were resolved, these conjugates were able to be organized on both linear DNA strands and origami tiles with the desired spacing between the proteins. No interactions between either template-bound or free-floating FliG proteins could be observed however, meaning a new strategy was needed. One model of cytoplasmic ring assembly predicts that binding of FliG to the C-terminal domain of the membrane-bound FliF protein induces a conformational change in both partners which then triggers interactions between neighbouring FliG proteins. To test this, I designed a peptide corresponding to the FliF_C domain of Salmonella and E. coli FliF and incorporated it into my system. Several biophysical assays indicated that the FliF_C peptide stably bound to purified wild-type Salmonella FliG and that binding to the peptide increased the overall stability of the protein. This constitutes the first confirmation that the cytoplasmic domain of FliF is sufficient for FliG binding in enteric bacteria. Following this discovery, a maleimide-modified DNA strand was then conjugated to a single-cysteine version of the peptide and the peptide-DNA conjugates organized with various stoichiometries and spacing on DNA templates to create an array of 'binding platforms' for the FliG protein. FliG bound to the organized peptides in a one-to-one fashion but interactions between the organized FliG proteins were still not detected. In a final effort to stimulate FliG-FliG binding, a radially-symmetric DNA nanostructure was designed with dimensions and a geometry which matched those found in the cytoplasmic rings of bacteria. Gels and AFM microscopy proved that the 12…

Subjects/Keywords: Synthetic Biology; Biophysics; Protein Biochemistry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Spratt, J. (2018). DNA-templated assembly of the bacterial flagellar motor's cytoplasmic ring. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:27428b51-4fb8-4964-95b6-d3cbb5db996d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770682

Chicago Manual of Style (16^th Edition):

Spratt, Joel. “DNA-templated assembly of the bacterial flagellar motor's cytoplasmic ring.” 2018. Doctoral Dissertation, University of Oxford. Accessed April 10, 2021. http://ora.ox.ac.uk/objects/uuid:27428b51-4fb8-4964-95b6-d3cbb5db996d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770682.

MLA Handbook (7^th Edition):

Spratt, Joel. “DNA-templated assembly of the bacterial flagellar motor's cytoplasmic ring.” 2018. Web. 10 Apr 2021.

Vancouver:

Spratt J. DNA-templated assembly of the bacterial flagellar motor's cytoplasmic ring. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Apr 10]. Available from: http://ora.ox.ac.uk/objects/uuid:27428b51-4fb8-4964-95b6-d3cbb5db996d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770682.

Council of Science Editors:

Spratt J. DNA-templated assembly of the bacterial flagellar motor's cytoplasmic ring. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:27428b51-4fb8-4964-95b6-d3cbb5db996d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770682

Rice University

29. Piepergerdes, Trenton Cole. INVESTIGATING OPTOGENETICS AS AN APPROACH TO CONTROL GROWTH FACTOR EXPRESSION FOR TISSUE ENGINEERING.

Degree: MS, Engineering, 2018, Rice University

URL: http://hdl.handle.net/1911/105817

► The body exhibits a robust capacity for regeneration when faced with tissue injury or damage. In some cases, however, these insults can exceed the innate… (more)

▼ The body exhibits a robust capacity for regeneration when faced with tissue injury or damage. In some cases, however, these insults can exceed the innate capacity for healing, resulting in permanent loss of structure and function. It is in these injuries where tissue engineering seeks to design interventions that can restore structure and function through the implementation of scaffolds, bioactive factors, and/or cells. Bioactive proteins have demonstrated immense efficacy in inducing tissue formation, but the administration of these factors has seen limitations that prevent them from seeing clinical success. Namely, precise spatiotemporal delivery of these factors is critical to their function and has yet to be achieved through exogenous delivery methods. There is thus a need for technologies that enable precise spatiotemporal administration of growth factors for tissue engineering. To this end, we propose that the precisely tunable variables associated with light make it an ideal stimulus for growth factor administration. Specifically, we sought to explore two previously developed light responsive systems as tools for controllable growth factor expression in mammalian cells with our overall goal being to make a case for optogenetic tools for tissue engineering applications. First, we explored the functionality of a red light-inducible adeno-associated virus (AAV). We next investigated a near infrared (NIR) optically responsive transcription control system as tool for tuned growth factor delivery. Finally, we ran preliminary studies to explore the feasibility of working with optogenetic systems in three dimensions (3D) through characterization of the relationship between scaffold fabrication parameters and light absorbance. In all, we validated tools for optogenetic control of growth factor expression and demonstrated feasibility of the technique for growth factor delivery in tissue engineering. Advisors/Committee Members: Mikos, Antonios G. (advisor), Mikos, Jeffrey J. (committee member).

Subjects/Keywords: synthetic biology; tissue engineering; optogenetics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Piepergerdes, T. C. (2018). INVESTIGATING OPTOGENETICS AS AN APPROACH TO CONTROL GROWTH FACTOR EXPRESSION FOR TISSUE ENGINEERING. (Masters Thesis). Rice University. Retrieved from http://hdl.handle.net/1911/105817

Chicago Manual of Style (16^th Edition):

Piepergerdes, Trenton Cole. “INVESTIGATING OPTOGENETICS AS AN APPROACH TO CONTROL GROWTH FACTOR EXPRESSION FOR TISSUE ENGINEERING.” 2018. Masters Thesis, Rice University. Accessed April 10, 2021. http://hdl.handle.net/1911/105817.

MLA Handbook (7^th Edition):

Piepergerdes, Trenton Cole. “INVESTIGATING OPTOGENETICS AS AN APPROACH TO CONTROL GROWTH FACTOR EXPRESSION FOR TISSUE ENGINEERING.” 2018. Web. 10 Apr 2021.

Vancouver:

Piepergerdes TC. INVESTIGATING OPTOGENETICS AS AN APPROACH TO CONTROL GROWTH FACTOR EXPRESSION FOR TISSUE ENGINEERING. [Internet] [Masters thesis]. Rice University; 2018. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1911/105817.

Council of Science Editors:

Piepergerdes TC. INVESTIGATING OPTOGENETICS AS AN APPROACH TO CONTROL GROWTH FACTOR EXPRESSION FOR TISSUE ENGINEERING. [Masters Thesis]. Rice University; 2018. Available from: http://hdl.handle.net/1911/105817

Boston University

30. Thommes, Meghan. Strategies for engineering microbial communities.

Degree: PhD, Biomedical Engineering, 2020, Boston University

URL: http://hdl.handle.net/2144/41030

► Understanding how microbes assemble into communities is a fundamental open question in biology, with applications to human health, environmental sustainability, and metabolic engineering. Although it… (more)

▼ Understanding how microbes assemble into communities is a fundamental open question in biology, with applications to human health, environmental sustainability, and metabolic engineering. Although it is known that the competition and exchange of nutrients (i.e., metabolic interactions) shape microbial community structure and dynamics, the ability to reliably predict the metabolic interactions and their effect on microbial communities is still being studied. This dissertation investigates how metabolism and environment shape microbial communities through the use of mathematical models, based on linear programming (LP) and mixed integer linear programming (MILP) methods. The first system I studied is a synthetic microbial consortium composed of two species, Cellulomonas fimi and Yarrowia lipolytica, hypothesized to be able to jointly transform cellulose into biofuel precursors. I combined experimental data and flux balance analysis (FBA) to test our capacity to predict metabolic interactions between the two organisms, and explored a proof-of-concept method to monitor the growth dynamics of this coculture. I next explored the possibility of generalizing the design of synthetic communities through the implementation of a computational method that can design division of labor strategies. The algorithm finds consortia of engineered bacterial strains that can survive by exchanging with each other specific nutrients. By distributing functions, microbial consortia can perform tasks that are impossible for individual species to accomplish alone. In addition to highlighting the trade-off between metabolic self-reliance and mutualistic exchange, this approach suggests how division of labor may arise in Escherichia coli monocultures. While mechanistic models are helpful for studying metabolism in microbes and microbial communities, it is interesting to ask whether increasingly cheaper high-throughput phenotypic data, can help achieve similar goals. To address this question, I developed a computational approach to investigate the relationship between growth profiles and microbial species, based on the identification of growth conditions that can best represent the whole dataset. This approach can help engineer microbial communities by identifying microbes that are more likely to engage in cross-feeding, rather than competition, based on their phenotypic profiles. In general, this dissertation demonstrates how different types of metabolic modeling approaches, both mechanism-based and data-driven, can be used to predict metabolic interactions between members of microbial consortia, and to help engineer novel synthetic communities. Advisors/Committee Members: Segre, Daniel (advisor).

Subjects/Keywords: Biomedical engineering; Synthetic ecology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thommes, M. (2020). Strategies for engineering microbial communities. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/41030

Chicago Manual of Style (16^th Edition):

Thommes, Meghan. “Strategies for engineering microbial communities.” 2020. Doctoral Dissertation, Boston University. Accessed April 10, 2021. http://hdl.handle.net/2144/41030.

MLA Handbook (7^th Edition):

Thommes, Meghan. “Strategies for engineering microbial communities.” 2020. Web. 10 Apr 2021.

Vancouver:

Thommes M. Strategies for engineering microbial communities. [Internet] [Doctoral dissertation]. Boston University; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2144/41030.

Council of Science Editors:

Thommes M. Strategies for engineering microbial communities. [Doctoral Dissertation]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41030

Open Access Theses and Dissertations