You searched for subject:(Suzuki reaction).
Showing records 1 – 30 of
49 total matches.
◁ [1] [2] ▶
University of South Africa
1.
Oyeyiola, Felix Adetunji.
Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones
.
Degree: 2011, University of South Africa
URL: http://hdl.handle.net/10500/5842 
► The 2-aryl-2,3-dihydroquinolin-4(1H)-ones were prepared via acid-catalyzed cyclization of the corresponding 2-aminochalcones, which were in turn, prepared by base-promoted Claisen-Schmidt aldol condensation of 2-aminoacetophenone and benzaldehyde…
(more)
▼ The 2-aryl-2,3-dihydroquinolin-4(1H)-ones were prepared via acid-catalyzed cyclization of the corresponding 2-aminochalcones, which were in turn, prepared by base-promoted Claisen-Schmidt aldol condensation of 2-aminoacetophenone and benzaldehyde derivatives. The 2-aryl-6,8-dibromo-2,3-dihydroquinolin-4(1H)-ones were prepared by reacting 2-aryl-2,3-dihydroquinolin-4(1H)-ones with N-bromosuccinimide (NBS) in carbon tetrachloride-chloroform mixture at room temperature. The 2-aryl-6,8-dibromo-2,3-dihydroquinolin-4(1H)-ones were subjected to palladium-catalyzed
Suzuki-Miyaura cross-coupling
reaction with arylboronic acid using dichlorobis(triphenylphosphine)palladium(II)-tricycohexylphosphine as catalyst mixture and potassium carbonate as a base in dioxane-water under reflux to afford the corresponding novel 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones in a single-pot operation. The latter were subjected to thallium(III) p-tolylsulfonate in dimethoxyethane under reflux to yield the 2,6,8-triarylquinolin-4(1H)-ones. The 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones were treated with molecular iodine in refluxing methanol to afford the corresponding 2,6,8-triaryl-4-methoxyquinolines. All the new compounds were characterized using a combination of 1H NMR & 13C NMR spectroscopy, IR and mass spectroscopic techniques.
Advisors/Committee Members: Mphahlele, M.J (advisor).
Subjects/Keywords: 2-aminochalcones;
Cross-coupling reaction;
Suzuki-Miyaura
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Oyeyiola, F. A. (2011). Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones
. (Masters Thesis). University of South Africa. Retrieved from http://hdl.handle.net/10500/5842
Chicago Manual of Style (16th Edition):
Oyeyiola, Felix Adetunji. “Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones
.” 2011. Masters Thesis, University of South Africa. Accessed October 16, 2019.
http://hdl.handle.net/10500/5842.
MLA Handbook (7th Edition):
Oyeyiola, Felix Adetunji. “Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones
.” 2011. Web. 16 Oct 2019.
Vancouver:
Oyeyiola FA. Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones
. [Internet] [Masters thesis]. University of South Africa; 2011. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/10500/5842.
Council of Science Editors:
Oyeyiola FA. Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones
. [Masters Thesis]. University of South Africa; 2011. Available from: http://hdl.handle.net/10500/5842
2.
Takimoto, Herick Garcia.
Estudo de polifluorenos como camada emissora de dispositivos eletroluminescentes eficientes.
Degree: Mestrado, Engenharia Metalúrgica e de Materiais, 2013, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/3/3133/tde-23052014-014442/
;
► Este trabalho tem como principais objetivos: desenvolver procedimentos sintéticos e novos materiais poliméricos que apresentem boa condutividade elétrica, estudar o comportamento eletro-óptico dos polímeros obtidos,…
(more)
▼ Este trabalho tem como principais objetivos: desenvolver procedimentos sintéticos e novos materiais poliméricos que apresentem boa condutividade elétrica, estudar o comportamento eletro-óptico dos polímeros obtidos, desenvolver procedimentos para a construção de dispositivos eletroluminescentes, caracterizá-los e correlacionar as características eletro-ópticas observadas com a constituição da camada ativa polimérica. Foram realizadas diversas sínteses objetivando a preparação de polifluorenos com diferentes estruturas químicas a partir de monômeros difuncionais aromáticos boronados e bromados, utilizando uma mesma rota de acoplamento de Suzuki. Assim, foram preparados três polímeros, poli[2,7-(9,9-dioctilfluoreno)] (PF, polifluoreno), poli[1,4-fenileno-alt-2,7- (9,9-dioctilfluoreno)] [PFP, poli(fluoreno-fenileno)] e poli[(1,4-fenileno-2-flúor)-alt-2,7-(9,9- dioctilfluoreno)] [PFPF, poli(fluoreno-fenileno)fluorado]. Para obtenção destes polifluorenos com bom rendimento e com pureza adequada para a preparação de dispositivos poliméricos eletroluminescentes, foi necessário testar diversas condições de reação, até a otimização de um procedimento sintético robusto. Os polifluorenos preparados foram exaustivamente purificados por extração e solubilização-precipitação. Todos os polifluorenos tiveram a sua estrutura e composição químicas caracterizadas e confirmadas pelas técnicas de espectroscopia no infravermelho (FTIR), espectroscopia de ressonância magnética nuclear de hidrogênio (¹HNMR) e espectroscopia de energia dispersiva de raios-X (EDX). As massas molares médias e a polidispersão foram determinadas por cromatografia de permeação em gel (GPC). Soluções em clorofórmio dos polifluorenos foram analisadas por espectroscopias de absorção e emissão no UV-Vis. Estes resultados nos forneceram informações importantes quanto às propriedades de fotoluminescência dos polifluorenos obtidos. Até o momento, sabe-se que todos os três polímeros emitem cor azul e dentre as três estruturas estudadas, o PFPF apresentou maior intensidade de fluorescência. Para a fabricação dos P-OLEDs (Diodos Orgânico-Polimérico Emissor de Luz) foram feitas soluções de clorofórmio em concentrações de 1% dos três tipos de polímeros. Também foi estudada a influência dos compostos ETL (electron transport layer) (Alq3 ou butyl-PBD) com concentrações de 0,5%. Quando aplicada uma tensão no dispositivo, o PFPF apresentou menor tensão de operação entre os polímeros estudados. A partir das curvas de tensão vs. corrente, verificou-se que a adição do butyl-PBD nos três tipos de polímeros diminui a tensão de limiar em comparação com os dispositivos sem composto ETL. Os comprimentos de onda de eletroluminescência dos dispositivos polarizados permaneceram constante mesmo com a adição dos dois compostos ETL (Alq3 ou butyl-PBD).
This work has as main objectives: develop synthetic procedures and new electroluminescent polymeric materials that have good electrical conductivity, study the behavior of polymer systems thus obtained, and develop procedures for the…
Advisors/Committee Members: Wang, Shu Hui.
Subjects/Keywords: ITO; ITO; P-OLEDs; P-OLEDs; Polifluoreno; Polyfluorene; Reação Suzuki; Suzuki reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Takimoto, H. G. (2013). Estudo de polifluorenos como camada emissora de dispositivos eletroluminescentes eficientes. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/3/3133/tde-23052014-014442/ ;
Chicago Manual of Style (16th Edition):
Takimoto, Herick Garcia. “Estudo de polifluorenos como camada emissora de dispositivos eletroluminescentes eficientes.” 2013. Masters Thesis, University of São Paulo. Accessed October 16, 2019.
http://www.teses.usp.br/teses/disponiveis/3/3133/tde-23052014-014442/ ;.
MLA Handbook (7th Edition):
Takimoto, Herick Garcia. “Estudo de polifluorenos como camada emissora de dispositivos eletroluminescentes eficientes.” 2013. Web. 16 Oct 2019.
Vancouver:
Takimoto HG. Estudo de polifluorenos como camada emissora de dispositivos eletroluminescentes eficientes. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2019 Oct 16].
Available from: http://www.teses.usp.br/teses/disponiveis/3/3133/tde-23052014-014442/ ;.
Council of Science Editors:
Takimoto HG. Estudo de polifluorenos como camada emissora de dispositivos eletroluminescentes eficientes. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/3/3133/tde-23052014-014442/ ;
Johannes Gutenberg Universität Mainz
3.
Breuch, Denis.
Kontinuierliche Kreuzkupplungsreaktionen in mikrostrukturierten Systemen.
Degree: 2013, Johannes Gutenberg Universität Mainz
URL: http://ubm.opus.hbz-nrw.de/volltexte/2013/3443/
► Im Rahmen dieser Arbeit wurden unterschiedliche Palladium-katalysierte Kreuzkupplungsreaktionen untersucht. Ein besonderes Augenmerk wurde dabei auf die Suzuki-Miyaura-Reaktion gelegt. Unter anderem aufgrund der langen Reaktionszeiten und…
(more)
▼ Im Rahmen dieser Arbeit wurden unterschiedliche Palladium-katalysierte Kreuzkupplungsreaktionen untersucht. Ein besonderes Augenmerk wurde dabei auf die Suzuki-Miyaura-Reaktion gelegt. Unter anderem aufgrund der langen Reaktionszeiten und der zweiphasigen Bedingungen ist diese Reaktionsklasse nur sehr schwer als kontinuierlicher Prozess zu etablieren. Vielen dieser Ansätze ist jedoch zu eigen, dass der große Vorteil der Mikroprozesstechnik, eine überlegene Kontrolle von Temperatur und Stofftransport, kaum ausgeschöpft wird. An diesem Punkt setzt diese Arbeit von technischer aus Seite an. Der zweite Schwerpunkt der Arbeit sind die prinzipiellen Untersuchungen an kontinuierlichen Flüssig-Flüssig-Zwei-Phasen-Reaktionen. Im Zuge des DBU-finanzierten Transkat-Projektes wurden hierbei anhand einfacher Veresterungsreaktionen grundlegende Kenntnisse zu Stofftransport, Grenzflächen und Phasentrennung innerhalb mikrostrukturierter Systeme gesammelt. Dank speziell angefertigter Glasmikroreaktoren von der Firma mikroglas chemtech GmbH war eine genaue optische und digitale Charakterisierung der Phasengrenzflächen möglich. Ein wichtiges Ergebnis war darüber hinaus, dass ionische Flüssigkeiten, als eigenständige Phasen verwendet, enorm zum Massentransfer und somit zur Reaktionsgeschwindigkeit beitragen können.
In this study, different palladium-catalyzed cross-coupling reactions were examined. Special attention was paid to the Suzuki-Miyaura reaction. The long reaction times and the biphasic reaction conditions make it difficult to optimize a continuous flow synthesis. Many of the previously described approaches, however, do not use the advantages of micro process technology, i.e. superior control of temperature and mass transfer. The aim of this study was to optimize these parameters. Special emphasis was also placed on the general optimization of continuous liquid-liquid two-phase reactions. In the course of the DBU-funded project Transkat, more information about mass transports, interfacial areas and phase separations in microstructured systems was collected via simple esterification reactions. Because of custom-made glass microreactors of the mikroglas chemtech GmbH, a precise optical and digital characterization of the interfacial areas was possible. Another important result was that ionic liquids, if used as an separate phases, can fuel an enormous mass transfer and thus increase the reaction rate.
Subjects/Keywords: Mikroreaktor; Suzuki-Reaktion; ionische Flüssigkeit; micro reactor; Suzuki reaction; ionic liquid; Chemistry and allied sciences
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Breuch, D. (2013). Kontinuierliche Kreuzkupplungsreaktionen in mikrostrukturierten Systemen. (Doctoral Dissertation). Johannes Gutenberg Universität Mainz. Retrieved from http://ubm.opus.hbz-nrw.de/volltexte/2013/3443/
Chicago Manual of Style (16th Edition):
Breuch, Denis. “Kontinuierliche Kreuzkupplungsreaktionen in mikrostrukturierten Systemen.” 2013. Doctoral Dissertation, Johannes Gutenberg Universität Mainz. Accessed October 16, 2019.
http://ubm.opus.hbz-nrw.de/volltexte/2013/3443/.
MLA Handbook (7th Edition):
Breuch, Denis. “Kontinuierliche Kreuzkupplungsreaktionen in mikrostrukturierten Systemen.” 2013. Web. 16 Oct 2019.
Vancouver:
Breuch D. Kontinuierliche Kreuzkupplungsreaktionen in mikrostrukturierten Systemen. [Internet] [Doctoral dissertation]. Johannes Gutenberg Universität Mainz; 2013. [cited 2019 Oct 16].
Available from: http://ubm.opus.hbz-nrw.de/volltexte/2013/3443/.
Council of Science Editors:
Breuch D. Kontinuierliche Kreuzkupplungsreaktionen in mikrostrukturierten Systemen. [Doctoral Dissertation]. Johannes Gutenberg Universität Mainz; 2013. Available from: http://ubm.opus.hbz-nrw.de/volltexte/2013/3443/
University of Edinburgh
4.
Geogheghan, Katherine Jayne.
Boronic acid speciation in Suzuki-Miyaura cross-coupling.
Degree: PhD, 2018, University of Edinburgh
URL: http://hdl.handle.net/1842/33092
► Since its discovery in 1979, the Suzuki-Miyaura (SM) reaction has become one of the most widely utilised tools for carbon-carbon bond formation. The palladium catalysed…
(more)
▼ Since its discovery in 1979, the Suzuki-Miyaura (SM) reaction has become one of the most widely utilised tools for carbon-carbon bond formation. The palladium catalysed coupling of an organoboron and organohalide compounds proceeds through a three-stage mechanism of oxidative addition, transmetalation and reductive elimination. The transmetalation of boronic acids to a palladium(II) complex has been widely studied. However, very little is known about the transmetalation of boronic esters, which are commonly used as an alternative to unstable boronic acids. Whether these species undergo direct transmetalation or prior hydrolysis to the boronic acid under SM conditions remains unknown. This research aimed to elucidate the mechanism of this cross-coupling process. Initial results under typical SM conditions created a biphasic reaction, promoted by the inorganic base and solvent composition, and showed that the boronic esters and corresponding boronic acid couple at the same absolute rate. This is thought to be a consequence of the formation of a biphasic mixture, rendering phase transfer the turnover-limiting step. The conditions were thus adapted to maintain a monophasic system using an organic soluble base, 2-tert-butyl-1,1,3,3-tetramethylguanidine, enabling the focus to be transmetalation as the turnover-limiting step. These new conditions show a significant difference in both reaction rate and induction period when using a boronic ester compared to the corresponding boronic acid. The use of guanidine was also shown to have an interesting effect on the boronic acid/ester species by 19F and 11B NMR. Further studies found the use of guanidine to create a boronate species, with this species being an aryl trihydroxyboronate or the hydroxyl"ate"-complex of the boronic ester, depending on the presence of diol in the system. Formation of a boronate species was found to be crucial for efficient cross-coupling. When testing weaker bases, unable to form a boronate species, poor SM cross-coupling conversion was found using the newly developed phosphine-free guanidine conditions, showing the importance of the boronate species under these conditions. The results suggest that depending on the strength of base used, the pathway of transmetalation pathway can be switched, between the boronate pathway and the oxo-palladium pathway, under the specific conditions developed.
Subjects/Keywords: cross-coupling; Suzuki-Miyaura reaction; palladium catalysed coupling; boronic esters
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Geogheghan, K. J. (2018). Boronic acid speciation in Suzuki-Miyaura cross-coupling. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/33092
Chicago Manual of Style (16th Edition):
Geogheghan, Katherine Jayne. “Boronic acid speciation in Suzuki-Miyaura cross-coupling.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed October 16, 2019.
http://hdl.handle.net/1842/33092.
MLA Handbook (7th Edition):
Geogheghan, Katherine Jayne. “Boronic acid speciation in Suzuki-Miyaura cross-coupling.” 2018. Web. 16 Oct 2019.
Vancouver:
Geogheghan KJ. Boronic acid speciation in Suzuki-Miyaura cross-coupling. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/1842/33092.
Council of Science Editors:
Geogheghan KJ. Boronic acid speciation in Suzuki-Miyaura cross-coupling. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/33092
Boston College
5.
Eliseeva, Maria N.
New Route to a [5,5] Carbon Nanotube End-Cap via Direct
Borylation of Corannulene.
Degree: MS, Chemistry, 2011, Boston College
URL: http://dlib.bc.edu/islandora/object/bc-ir:101796
► The Scott lab is interested in the functionalization of corannulene as a building block for large polycyclic aromatic hydrocarbons and carbon nanotube end-cap precursors. Toward…
(more)
▼ The Scott lab is interested in the functionalization
of corannulene as a building block for large polycyclic aromatic
hydrocarbons and carbon nanotube end-cap precursors. Toward that
end, a new approach to the direct five-fold borylation of
corannulene with iridium (I) catalysts via C-H activation has been
explored. It has been discovered that the addition of catalytic
amounts of base to the
reaction mixture promotes the formation of
symmetrical penta-borylated corannulene in a good yield on a
sizable scale. All byproducts can be easily removed with iterative
methanol washes. The present work also provides proof of the
reversibility of the direct borylation
reaction under the
conditions used. Furthermore, modified
Suzuki-Miyaura conditions
have been employed to synthesize
pentakis(2,6-dichlorophenyl)corannulene, a precursor for a [5,5]
carbon nanotube end-cap. The reported reactions provide good yields
and are scalable.
Advisors/Committee Members: Lawrence T. Scott (Thesis advisor).
Subjects/Keywords: carbon nanotube; corannulene; direct borylation; iridium catalyst; Suzuki reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Eliseeva, M. N. (2011). New Route to a [5,5] Carbon Nanotube End-Cap via Direct
Borylation of Corannulene. (Masters Thesis). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:101796
Chicago Manual of Style (16th Edition):
Eliseeva, Maria N. “New Route to a [5,5] Carbon Nanotube End-Cap via Direct
Borylation of Corannulene.” 2011. Masters Thesis, Boston College. Accessed October 16, 2019.
http://dlib.bc.edu/islandora/object/bc-ir:101796.
MLA Handbook (7th Edition):
Eliseeva, Maria N. “New Route to a [5,5] Carbon Nanotube End-Cap via Direct
Borylation of Corannulene.” 2011. Web. 16 Oct 2019.
Vancouver:
Eliseeva MN. New Route to a [5,5] Carbon Nanotube End-Cap via Direct
Borylation of Corannulene. [Internet] [Masters thesis]. Boston College; 2011. [cited 2019 Oct 16].
Available from: http://dlib.bc.edu/islandora/object/bc-ir:101796.
Council of Science Editors:
Eliseeva MN. New Route to a [5,5] Carbon Nanotube End-Cap via Direct
Borylation of Corannulene. [Masters Thesis]. Boston College; 2011. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101796
University of South Carolina
6.
Key, Ryan J.
Development of Nickel Catalyzed Cross-Coupling Methodologies.
Degree: PhD, Chemistry and Biochemistry, 2019, University of South Carolina
URL: https://scholarcommons.sc.edu/etd/5324
► In this work, we have addressed some of the issues surrounding catalytic crosscoupling reactions by using a nickel terpyridine catalyst, [Ni(tpy)(py)(CH3CN)2](PF6)2 in the Buchwald-Hartwig…
(more)
▼ In this work, we have addressed some of the issues surrounding catalytic crosscoupling reactions by using a nickel terpyridine catalyst, [Ni(tpy)(py)(CH3CN)2](PF6)2 in the Buchwald-Hartwig amination
reaction and a functionalized variant, [(2,2':6',2''- terpyridine-4'-benzoic acid)Ni(II)]Cl2 on SiO2, in
Suzuki coupling. These processes are unique in the approaches taken to achieve reactivity. In the Buchwald-Hartwig amination
reaction, we used photoredox dual catalytic methods to achieve a sustainable approach to generate secondary and tertiary amines. This report is unique in many ways; most importantly, this method uses N-centered radicals to generate new C-N bonds. This report is also the first report to show generation of secondary and tertiary amines in the same
reaction scaffold. For the
Suzuki reaction, we developed a heterogeneous nickel catalyst by immobilization of a nickel terpyridine analogue on a solid oxide support. By doing so, we created a recyclable catalyst that can operate up to five reactions before suffering deactivation. The approach is more effective than homogeneous reactions, as the catalyst is easily reclaimed and simplifies both purification and analysis. We further developed this process by immobilizing the molecular catalyst using Atomic Layer Deposition. This approach allows for a physical barrier to be added to the catalyst motif that increases practical stability. Indeed, the immobilization worked effectively, allowing more than six reactions without any catalyst deactivation in aqueous solvents. After immobilization, activity was observed towards heteroaryl substrates, a useful moiety in pharmaceutical drug targets.
Advisors/Committee Members: Aaron K. Vannucci.
Subjects/Keywords: Chemistry; nickel; cross-coupling; Atomic Layer Deposition; Suzuki reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Key, R. J. (2019). Development of Nickel Catalyzed Cross-Coupling Methodologies. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/5324
Chicago Manual of Style (16th Edition):
Key, Ryan J. “Development of Nickel Catalyzed Cross-Coupling Methodologies.” 2019. Doctoral Dissertation, University of South Carolina. Accessed October 16, 2019.
https://scholarcommons.sc.edu/etd/5324.
MLA Handbook (7th Edition):
Key, Ryan J. “Development of Nickel Catalyzed Cross-Coupling Methodologies.” 2019. Web. 16 Oct 2019.
Vancouver:
Key RJ. Development of Nickel Catalyzed Cross-Coupling Methodologies. [Internet] [Doctoral dissertation]. University of South Carolina; 2019. [cited 2019 Oct 16].
Available from: https://scholarcommons.sc.edu/etd/5324.
Council of Science Editors:
Key RJ. Development of Nickel Catalyzed Cross-Coupling Methodologies. [Doctoral Dissertation]. University of South Carolina; 2019. Available from: https://scholarcommons.sc.edu/etd/5324
University of South Africa
7.
Makelane, Hlamulo Reply.
Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes
.
Degree: 2010, University of South Africa
URL: http://hdl.handle.net/10500/3838
► Sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline derivatives with stoichiometric amount of terminal alkynes in the presence of bis(triphenylphosphine)palladium(II)chloride and copper iodide in triethylamine afforded the 3-(alkynyl)-2-aryl-4-chloroquinoline, exclusively.…
(more)
▼ Sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline derivatives with stoichiometric amount of terminal alkynes in the presence of bis(triphenylphosphine)palladium(II)chloride and copper iodide in triethylamine afforded the 3-(alkynyl)-2-aryl-4-chloroquinoline, exclusively. On the other hand, the 2-aryl-4-chloro-3-iodoquinolines with excess (2.5 equiv.) of terminal alkynes in the presence of PdCl2(PPh3)2-CuI catalyst mixture and NEt3 in dioxane-water (3:1 v/v) afforded the 2-aryl-3,4-bis(alkynyl)quinoline derivatives in a one-step operation.
Further transformation of the 2-aryl-3-(alkynyl)-4-chloroquinoline via
Suzuki cross-coupling
reaction with boronic acid derivatives in the presence of tetrakis(triphenylphosphine)palladium and tricyclohexylphosphine as a ligand in dioxane-water (3:1 v/v) afforded the 2,4-diaryl-3-(alkynyl)quinolines in moderate to high yields. The 2-aryl-3-(alkynyl)-4-chloroquinolines were also transformed to the corresponding 2-aryl-4-(methylamino)-3-(alkynyl)quinoline derivatives using methylamine in ethanol under reflux.
Advisors/Committee Members: Mphahlele, M. J (advisor).
Subjects/Keywords: 2-aryl-4-chloro-3-iodoquinoline;
Sonogashira cross-coupling reaction;
Suzuki cross-coupling reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Makelane, H. R. (2010). Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes
. (Masters Thesis). University of South Africa. Retrieved from http://hdl.handle.net/10500/3838
Chicago Manual of Style (16th Edition):
Makelane, Hlamulo Reply. “Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes
.” 2010. Masters Thesis, University of South Africa. Accessed October 16, 2019.
http://hdl.handle.net/10500/3838.
MLA Handbook (7th Edition):
Makelane, Hlamulo Reply. “Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes
.” 2010. Web. 16 Oct 2019.
Vancouver:
Makelane HR. Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes
. [Internet] [Masters thesis]. University of South Africa; 2010. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/10500/3838.
Council of Science Editors:
Makelane HR. Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes
. [Masters Thesis]. University of South Africa; 2010. Available from: http://hdl.handle.net/10500/3838
Universidade Federal de Viçosa
8.
Guilherme Carvalho Geraldo.
Síntese e avaliação da atividade fitotóxica de análogos ao alternariol.
Degree: 2008, Universidade Federal de Viçosa
URL: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=1891
► O alternariol é uma lactona aromática produzida por espécies fúngicas fitopatogênicas dos gêneros Nimbya e Alternaria. Estas espécies são conhecidas por causarem necroses foliares ocasionando…
(more)
▼ O alternariol é uma lactona aromática produzida por espécies fúngicas fitopatogênicas dos gêneros Nimbya e Alternaria. Estas espécies são conhecidas por causarem necroses foliares ocasionando a morte da planta, inclusive de espécies de plantas daninhas como Alternathera philoxeroides. Acredita-se que parte da fitotoxicidade destes fungos esteja associada à produção deste composto, podendo estar presentes também outros metabólitos secundários. O presente trabalho teve por objetivos sintetizar análogos ao alternariol e avaliar a atividade fitotóxica dos mesmos. Para a síntese destes foram utilizados dois tipos de aldeídos aromáticos (2-bromo-4,6- dimetoxibenzaldeído, obtido por formilação de Vilsmeyer, e 2- bromobenzaldeído) que foram acoplados com diversos ácidos borônicos através da reação de acoplamento de Suzuki. As biarilas resultantes foram oxidadas com clorito de sódio (NaClO2) para obtenção dos ácidos carboxílicos correspondentes, que foram tratados com tribrometo de boro (BBr3) para a desproteção dos grupos hidroxilas com conseqüente ciclização e formação do anel lactônico dos análogos ao alternariol. Desta forma foram obtidos oito novos compostos: 7,9-diidroxi-2-metil-6Hbenzo[c]cromen-6-ona (34,5%), 2-cloro-7,9-diidroxi-6H-benzo[c]cromen-6-ona (55,0%), 3-fluoro-7,9-diidroxi-6H-benzo[c]cromen-6-ona (48,5%), 2-fluoro-7,9-diidroxi-6H-benzo[c]cromen-6-ona (69,0%), 2-metil-6Hbenzo[c]cromen-6-ona (79,0%), 2-cloro- 6H-benzo[c]cromen-6-ona (93,5%), 3-fluoro-6H-benzo[c] cromen-6-ona (97,2%), 2-fluoro-6H-benzo[c]cromen-6-ona (93,3%). Os compostos sintetizados foram caracterizados, utilizando-se espectroscopia no IV, espectrometria de massas, espectroscopia de RMN de 1H e de 13C, além de técnicas bidimensionais de RMN como HETCOR. Para a avaliação da atividade fitotóxica foram testadas apenas três substâncias (7,9-diidroxi-2-metil-6H-benzo[c]cromen-6-ona, 2-cloro-7,9-diidroxi-6H-benzo[c]cromen-6-ona e 2-metil-6H- benzo[c]cromen-6-ona) em virtude da indisponibilidade de cloroplastos frescos na Itália na época em que os demais compostos foram sinteitzados. As três substâncias foram avaliadas por meio da chamada reação de Hill, que mede a capacidade que determinados compostos tem de inibir o transporte de elétrons em uma fotossíntese in vitro, tendo o ferricianeto de potássio como o aceptor não-biológico de elétrons. Para isto, foram utilizados cloroplastos, intactos, isolados de folhas de espinafre (Spinacia oleracea). Dentre as substâncias testadas, duas delas tiveram resultados de inibição bastante expressivos, no qual 2-cloro-7,9-diidroxi-6H- benzo[c]cromen-6-ona e 7,9-diidroxi-2-metil-6H-benzo[c] cromen-6-ona apresentaram valores de IC50 iguais a 7,2 e 22,8 μM, respectivamente.
Alternariol is an aromatic lactone produced by fungal phytopathogenic species of Nimbya and Alternaria. These species are known to cause leaf necrosis that generate the death of the plant, including species of weeds like Alternanthera philoxeroides. Its believed that the phytotoxicity of these fungi is associated with the production of…
Advisors/Committee Members: Luiz Claudio de Almeida Barbosa, Antônio Jacinto Demuner, Elson Santiago de Alvarenga, Célia Regina Alvares Maltha, Robson Ricardo Teixeira, Gaspar Diaz Muñoz.
Subjects/Keywords: Alternariol; Herbicidas; Fungos fitopatogênicos; Acoplamento de Suzuki; QUIMICA ORGANICA; Alternariol; Herbicides; Plant pathogenic fungi; Suzuki coupling reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Geraldo, G. C. (2008). Síntese e avaliação da atividade fitotóxica de análogos ao alternariol. (Thesis). Universidade Federal de Viçosa. Retrieved from http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=1891
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Geraldo, Guilherme Carvalho. “Síntese e avaliação da atividade fitotóxica de análogos ao alternariol.” 2008. Thesis, Universidade Federal de Viçosa. Accessed October 16, 2019.
http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=1891.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Geraldo, Guilherme Carvalho. “Síntese e avaliação da atividade fitotóxica de análogos ao alternariol.” 2008. Web. 16 Oct 2019.
Vancouver:
Geraldo GC. Síntese e avaliação da atividade fitotóxica de análogos ao alternariol. [Internet] [Thesis]. Universidade Federal de Viçosa; 2008. [cited 2019 Oct 16].
Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=1891.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Geraldo GC. Síntese e avaliação da atividade fitotóxica de análogos ao alternariol. [Thesis]. Universidade Federal de Viçosa; 2008. Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=1891
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vilnius University
9.
Dodonova, Jelena.
Pirolo[2,3-d]pirimidino oligoarilenų sintezė ir
fotofizikinės savybės.
Degree: PhD, Chemistry, 2012, Vilnius University
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092617-49864
;
► Šio darbo tikslas buvo susintetinti pirolo[2,3-d]pirimidino oligoarilenus ir ištirti jų fotofizikines savybes. Rezultate, ištirta 2,4-dichlorpirolo[2,3-d]pirimidino Suzuki reakcija su arilborono rūgštimis bei susintetinti nauji 4-aril- ir…
(more)
▼ Šio darbo tikslas buvo susintetinti
pirolo[2,3-d]pirimidino oligoarilenus ir ištirti jų fotofizikines
savybes. Rezultate, ištirta 2,4-dichlorpirolo[2,3-d]pirimidino
Suzuki reakcija su arilborono rūgštimis bei susintetinti nauji
4-aril- ir 2,4-diarilpirolo[2,3-d]pirimidinai. Pasiūlyta katalitinė
sistema bei surastos reakcijos sąlygos, leidžiančios
regioselektyviai atlikti Suzuki kryžminio jungimo reakciją
2,4-dichlorpirolo[2,3-d]pirimidine. Ištirta variu(I) katalizuojama
N-arilinimo reakcija tarp 2,4-diarilpirolo[2,3-d]pirimidinų ir
įvairių arilhalogenidų, dihalokarbazolų ir dihalofluorenų bei
susintetinti 2,4,7-triarilpirolo[2,3-d]pirimidinai,
bis(pirolo[2,3-d]pirimidin-7-il)karbazolai ir atitinkami fluorenai.
Sukurtas būdas, leidžiantis sintetinti pirolo[2,3-d]pirimidinus su
įvairiais pakaitais 2-, 4- ir 7-oje heterociklo padėtyse. Pirmą
kartą nustatyta, kad pirolo[2,3-d]pirimidino oligoarilenai pasižymi
mėlyna-UV fluorescencija tirpale ir kietame būvyje. Ištirta
arilgrupių struktūros, padėties pirolo[2,3-d]pirimidino žiede bei
pi-konjuguotos sistemos dydžio įtaka junginių fotoliuminescencinėms
savybėms. Nustatyta, kad kai kurie pirolo[2,3-d]pirimidino
oligoarilenai pasižymi teigiamu solvatofluorochrominiu efektu,
sudaro nanoagregatus tetrahidrofurano/vandens mišinyje. Nustatyta,
kad molekulių agregacija indukuoja emisijos padidėjimą. Parodyta,
kad pirolo[2,3-d]pirimidino oligomerai su išplėsta pi-konjuguota
sistema efektyviau fluorescuoja kietame būvyje nei
tirpale.
The main goal of the present work was to
synthesize pyrrolo[2,3-d]pyrimidine core based oligoarylenes and to
evaluate their photophysical properties. As a result, the Suzuki
reaction of 2,4-dichloropyrrolo[2,3-d]pyrimidine with arylboronic
acids was studied and novel 4-aryl- and
2,4-diarylpyrrolo[2,3-d]pyrimidines were synthesized. The reaction
conditions including an effective catalyst system for the Suzuki
cross-coupling reaction were proposed to achieve site-selectivity
of the reaction studied. A general approach for the preparation of
2,4,7-triarylpyrrolo[2,3-d]pyrimidines,
bis(pyrrolo[2,3-d]pyrimidin-7-yl)carbazoles and -fluorenes were
developed by copper-catalyzed N-arylation reaction of
2,4-diarylpyrrolo[2,3-d]pyrimidines with aryl halogenides,
dihalocarbazoles or dihalofluorenes. Synthetic strategies leading
to pyrrolo[2,3-d]pyrimidines with different aryl moieties in
positions 2, 4 and 7 of the heterocycle were studied and an
efficient method for their synthesis was developed. The synthesized
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes were found to
exhibit blue-UV fluorescence in solution and in solid state.
Influence of structure of aryl groups, their position in the
pyrrolo[2,3-d]pyrimidine nucleous and extent of pi-conjugated
aromatic system on the photoluminescent characteristics were
evaluated. Some pyrrolo[2,3-d]pyrimidine derivatives were found to
exhibit positive solvatofluorochromism and to form nanoaggregates
in THF/water mixtures with aggregation... [to full
text]
Advisors/Committee Members: Vainilavičius, Povilas (Doctoral dissertation committee chair), Butkus, Eugenijus (Doctoral dissertation committee member), Malinauskas, Albertas (Doctoral dissertation committee member), Mickevičius, Vytautas (Doctoral dissertation committee member), Undzėnas, Algimantas (Doctoral dissertation committee member), Burbulienė, Milda Malvina (Doctoral dissertation opponent), Getautis, Vytautas (Doctoral dissertation opponent), Tumkevičius, Sigitas (Doctoral dissertation supervisor).
Subjects/Keywords: Pirolo[2;
3-d]pirimidinas;
Fluorescencija; Suzuki
reakcija; N-arilinimas; Pyrrolo[2;
3-d]pyrimidine; Fluorescence; Suzuki
reaction; N-arylation
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dodonova, J. (2012). Pirolo[2,3-d]pirimidino oligoarilenų sintezė ir
fotofizikinės savybės. (Doctoral Dissertation). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092617-49864 ;
Chicago Manual of Style (16th Edition):
Dodonova, Jelena. “Pirolo[2,3-d]pirimidino oligoarilenų sintezė ir
fotofizikinės savybės.” 2012. Doctoral Dissertation, Vilnius University. Accessed October 16, 2019.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092617-49864 ;.
MLA Handbook (7th Edition):
Dodonova, Jelena. “Pirolo[2,3-d]pirimidino oligoarilenų sintezė ir
fotofizikinės savybės.” 2012. Web. 16 Oct 2019.
Vancouver:
Dodonova J. Pirolo[2,3-d]pirimidino oligoarilenų sintezė ir
fotofizikinės savybės. [Internet] [Doctoral dissertation]. Vilnius University; 2012. [cited 2019 Oct 16].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092617-49864 ;.
Council of Science Editors:
Dodonova J. Pirolo[2,3-d]pirimidino oligoarilenų sintezė ir
fotofizikinės savybės. [Doctoral Dissertation]. Vilnius University; 2012. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092617-49864 ;
Vilnius University
10.
Dodonova, Jelena.
Synthesis and photophysical properties of
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes.
Degree: Dissertation, Chemistry, 2012, Vilnius University
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092627-68184
;
► The main goal of the present work was to synthesize pyrrolo[2,3-d]pyrimidine core based oligoarylenes and to evaluate their photophysical properties. As a result, the Suzuki…
(more)
▼ The main goal of the present work was to
synthesize pyrrolo[2,3-d]pyrimidine core based oligoarylenes and to
evaluate their photophysical properties. As a result, the Suzuki
reaction of 2,4-dichloropyrrolo[2,3-d]pyrimidine with arylboronic
acids was studied and novel 4-aryl- and
2,4-diarylpyrrolo[2,3-d]pyrimidines were synthesized. The reaction
conditions including an effective catalyst system for the Suzuki
cross-coupling reaction were proposed to achieve site-selectivity
of the reaction studied. A general approach for the preparation of
2,4,7-triarylpyrrolo[2,3-d]pyrimidines,
bis(pyrrolo[2,3-d]pyrimidin-7-yl)carbazoles and -fluorenes were
developed by copper-catalyzed N-arylation reaction of
2,4-diarylpyrrolo[2,3-d]pyrimidines with aryl halogenides,
dihalocarbazoles or dihalofluorenes. Synthetic strategies leading
to pyrrolo[2,3-d]pyrimidines with different aryl moieties in
positions 2, 4 and 7 of the heterocycle were studied and an
efficient method for their synthesis was developed. The synthesized
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes were found to
exhibit blue-UV fluorescence in solution and in solid state.
Influence of structure of aryl groups, their position in the
pyrrolo[2,3-d]pyrimidine nucleous and extent of pi-conjugated
aromatic system on the photoluminescent characteristics were
evaluated. Some pyrrolo[2,3-d]pyrimidine derivatives were found to
exhibit positive solvatofluorochromism and to form nanoaggregates
in THF/water mixtures with aggregation... [to full
text]
Šio darbo tikslas buvo susintetinti
pirolo[2,3-d]pirimidino oligoarilenus ir ištirti jų fotofizikines
savybes. Rezultate, ištirta 2,4-dichlorpirolo[2,3-d]pirimidino
Suzuki reakcija su arilborono rūgštimis bei susintetinti nauji
4-aril- ir 2,4-diarilpirolo[2,3-d]pirimidinai. Pasiūlyta katalitinė
sistema bei surastos reakcijos sąlygos, leidžiančios
regioselektyviai atlikti Suzuki kryžminio jungimo reakciją
2,4-dichlorpirolo[2,3-d]pirimidine. Ištirta variu(I) katalizuojama
N-arilinimo reakcija tarp 2,4-diarilpirolo[2,3-d]pirimidinų ir
įvairių arilhalogenidų, dihalokarbazolų ir dihalofluorenų bei
susintetinti 2,4,7-triarilpirolo[2,3-d]pirimidinai,
bis(pirolo[2,3-d]pirimidin-7-il)karbazolai ir atitinkami fluorenai.
Sukurtas būdas, leidžiantis sintetinti pirolo[2,3-d]pirimidinus su
įvairiais pakaitais 2-, 4- ir 7-oje heterociklo padėtyse. Pirmą
kartą nustatyta, kad pirolo[2,3-d]pirimidino oligoarilenai pasižymi
mėlyna-UV fluorescencija tirpale ir kietame būvyje. Ištirta
arilgrupių struktūros, padėties pirolo[2,3-d]pirimidino žiede bei
pi-konjuguotos sistemos dydžio įtaka junginių fotoliuminescencinėms
savybėms. Nustatyta, kad kai kurie pirolo[2,3-d]pirimidino
oligoarilenai pasižymi teigiamu solvatofluorochrominiu efektu,
sudaro nanoagregatus tetrahidrofurano/vandens mišinyje. Nustatyta,
kad molekulių agregacija indukuoja emisijos padidėjimą. Parodyta,
kad pirolo[2,3-d]pirimidino oligomerai su išplėsta pi-konjuguota
sistema efektyviau fluorescuoja kietame būvyje nei
tirpale.
Advisors/Committee Members: Vainilavičius, Povilas (Doctoral dissertation committee chair), Butkus, Eugenijus (Doctoral dissertation committee member), Malinauskas, Albertas (Doctoral dissertation committee member), Mickevičius, Vytautas (Doctoral dissertation committee member), Undzėnas, Algimantas (Doctoral dissertation committee member), Burbulienė, Milda Malvina (Doctoral dissertation opponent), Getautis, Vytautas (Doctoral dissertation opponent), Tumkevičius, Sigitas (Doctoral dissertation supervisor).
Subjects/Keywords: Pyrrolo[2;
3-d]pyrimidine; Fluorescence; Suzuki
reaction; N-arylation; Pirolo[2;
3-d]pirimidinas;
Fluorescencija; Suzuki
reakcija; N-arilinimas
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dodonova, J. (2012). Synthesis and photophysical properties of
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes. (Doctoral Dissertation). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092627-68184 ;
Chicago Manual of Style (16th Edition):
Dodonova, Jelena. “Synthesis and photophysical properties of
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes.” 2012. Doctoral Dissertation, Vilnius University. Accessed October 16, 2019.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092627-68184 ;.
MLA Handbook (7th Edition):
Dodonova, Jelena. “Synthesis and photophysical properties of
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes.” 2012. Web. 16 Oct 2019.
Vancouver:
Dodonova J. Synthesis and photophysical properties of
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes. [Internet] [Doctoral dissertation]. Vilnius University; 2012. [cited 2019 Oct 16].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092627-68184 ;.
Council of Science Editors:
Dodonova J. Synthesis and photophysical properties of
pyrrolo[2,3-d]pyrimidine-core based oligoarylenes. [Doctoral Dissertation]. Vilnius University; 2012. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120917_092627-68184 ;
11.
François, Benjamin.
Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques : Functionalized organoboron compounds for the synthesis of polycyclic scaffolds.
Degree: Docteur es, Chimie moléculaire et macromoléculaire, 2018, Rennes 1
URL: http://www.theses.fr/2018REN1S114
► Les composés organoborés constituent des outils remarquables en synthèse organique de par leur chimie très diversifiée. Les travaux présentés dans ce mémoire abordent de nouveaux…
(more)
▼ Les composés organoborés constituent des outils remarquables en synthèse organique de par leur chimie très diversifiée. Les travaux présentés dans ce mémoire abordent de nouveaux aspects de leur réactivité. Une méthode de synthèse rapide et efficace de 9-hydroxyfluorènes est décrite via une séquence tandem Suzuki/ aldolisation phénolique. Ce processus a été ensuite étendu aux 9-aminofluorènes en ajoutant simplement comme troisième partenaire diverses amines au milieu réactionnel. Des hypothèses mécanistiques sont proposées pour rationaliser ces résultats expérimentaux. Dans une deuxième partie, est présentée une étude articulée autour de la mise en œuvre de réactions ène sur des diènes borylés 1,3. Les produits ainsi obtenus sont ensuite utilisés comme intermédiaires clé de structures polycycliques plus complexes. Enfin, le troisième chapitre est consacré à une nouvelle voie d'accès aux pyrroles C-fusionnés à partir de diènes cycliques borylés, ces derniers étant préparés par hydroboration d'énynes, bora-Wittig ou métathèse. Une grande diversité structurale est alors accessible à partir de ces précurseurs d'accès aisé.
Organoboron compounds are remarkable tools in organic synthesis due to their very diversified chemistry. The work presented in this thesis addresses new aspects of their reactivity. A rapid and efficient synthesis of 9-hydroxyfluorenes is described via a tandem Suzuki/phenol aldolisation sequence. This process was then extended to 9-aminofluorenes by simply adding various amines to the reaction medium as the third partner. Mechanistic hypotheses are proposed to rationalize these experimental results. In a second part, was presented a study articulated around the implementation of ene reactions on borylated 1,3-dienes. The products thus obtained are then used as key intermediates of more complex polycyclic scaffolds. Finally, the third chapter is dedicated to a new access to C-fused pyrroles from borylated cyclic dienes, the latter being prepared by hydroboration of enynes, boron-Wittig or metathesis reactions. A great structural diversity is then accessible from these easily prepared precursors.
Advisors/Committee Members: Berrée, Fabienne (thesis director), Carboni, Bertrand (thesis director).
Subjects/Keywords: Synthèse; Cascade; Organoboranes; Couplage de Suzuki; Réaction ène; Pyrrole; Synthesis; Cascade; Organoboranes; Suzuki coupling; Ene reaction; Pyrrole
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
François, B. (2018). Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques : Functionalized organoboron compounds for the synthesis of polycyclic scaffolds. (Doctoral Dissertation). Rennes 1. Retrieved from http://www.theses.fr/2018REN1S114
Chicago Manual of Style (16th Edition):
François, Benjamin. “Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques : Functionalized organoboron compounds for the synthesis of polycyclic scaffolds.” 2018. Doctoral Dissertation, Rennes 1. Accessed October 16, 2019.
http://www.theses.fr/2018REN1S114.
MLA Handbook (7th Edition):
François, Benjamin. “Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques : Functionalized organoboron compounds for the synthesis of polycyclic scaffolds.” 2018. Web. 16 Oct 2019.
Vancouver:
François B. Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques : Functionalized organoboron compounds for the synthesis of polycyclic scaffolds. [Internet] [Doctoral dissertation]. Rennes 1; 2018. [cited 2019 Oct 16].
Available from: http://www.theses.fr/2018REN1S114.
Council of Science Editors:
François B. Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques : Functionalized organoboron compounds for the synthesis of polycyclic scaffolds. [Doctoral Dissertation]. Rennes 1; 2018. Available from: http://www.theses.fr/2018REN1S114
12.
Fodor, Anna.
Heterogeneous metal-catalysed C-C coupling reactions : research and development : Réactions de couplage C-C réalisée par catalyse hétérogène : recherche et développement.
Degree: Docteur es, Chimie organique, minérale, industrielle, 2016, Poitiers; Budapesti Műszaki és Gazdaságtudományi Egyetem (Budapest)
URL: http://www.theses.fr/2016POIT2256
► Des nouveaux catalyseurs bimétalliques à base de palladium et de cuivre ont été développés. Deux voies de préparation ont été testées : l'imprégnation successive (TSI)…
(more)
▼ Des nouveaux catalyseurs bimétalliques à base de palladium et de cuivre ont été développés. Deux voies de préparation ont été testées : l'imprégnation successive (TSI) et la co-imprégnation (CI) en utilisant la zéolithe 4Å (4A) et l'oxyde mixte MgAlxOy comme support. Les catalyseurs ont été caractérisés à l'état frais et testés dans la réaction de couplage Suzuki–Miyaura afin de comparer leurs activités, sélectivités et stabilités. L'étude de stabilité nous a montré que le catalyseur Cu-Pd-4A-TSI restait actif pendant six cycles alors que l'activité du catalyseur Cu-Pd-4A-CI diminuait. Sur le support MgAlxOy, le catalyseur CI était stable pendant six cycles contrairement au catalyseur TSI. Nous avons montré que le point clé pour l'obtention d'une bonne activité et stabilité est la présence de la phase active correspondant à l'alliage Cu/Pd 1/1 identifiée grâce à la caractérisation des catalyseurs et ce quelle que soit la méthode de préparation des catalyseurs. Une différence cruciale existe entre les catalyseurs supportés sur MgAlxOy et 4A : le catalyseur Cu–Pd supporté sur MgAlxOy permet de réduire le temps de réaction de moitié pour une même conversion par rapport à Cu-Pd-4A-TSI. De plus, l'utilisation d'un support plus basique permet, dans une certaine mesure, la diminution de la quantité de la base ajoutée durant la réaction. La réaction Petasis-borono Mannich a été aussi effectuée avec succès sur ces catalyseurs.
New bimetallic palladium/copper catalysts were developed by successive impregnation (TSI) and co-impregnation (CI) on 4Å molecular sieve (4A) and MgAlO mixed oxides supports. The fresh catalysts were characterised and tested in the Suzuki–Miyaura reaction to test their activity, selectivity and stability. It was observed that while the Cu-Pd-4A-TSI catalyst kept its activity during six cycles that of the Cu-Pd-4A-CI dropped. On MgAlO support the catalyst prepared with CI proved to be stable even for six runs contrary to TSI. The active phase of the reaction – namely the Cu–Pd alloy with atomic ratio 1:1 - was determined with the help of catalyst characterisation of the recovered catalysts. This observation confirms that whatever the way of preparation or the support is, the key-point is the presence of Pd-Cu 1:1 particles to enhance the catalytic performances. A crucial difference between the MgAlO and 4A supported catalyst was found in the reaction time necessary for the Suzuki–Miyaura reaction. With the Cu-Pd-MgAl-CI catalyst the reaction time could be reduced to thirty minutes contrary to one hour with Cu-Pd-4A-TSI. Moreover it was concluded that with a more basic support the reduction of the quantity of the base was possible however it brought slightly decreasing yield. The Petasis-borono Mannich reaction was also performed in the presence of each mono-and bimetallic catalysts.
Advisors/Committee Members: Pirault-Roy, Laurence (thesis director), Hell, Zoltán (thesis director).
Subjects/Keywords: Catalyse bimétallique; Alliage cuivre-Palladium; Réaction de Suzuki; Réaction de Petasis; Effet du support; Bimetallic catalysis; Copper-Palladium alloy; Suzuki reaction; Petasis reaction; Effect of the support; 541.395
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fodor, A. (2016). Heterogeneous metal-catalysed C-C coupling reactions : research and development : Réactions de couplage C-C réalisée par catalyse hétérogène : recherche et développement. (Doctoral Dissertation). Poitiers; Budapesti Műszaki és Gazdaságtudományi Egyetem (Budapest). Retrieved from http://www.theses.fr/2016POIT2256
Chicago Manual of Style (16th Edition):
Fodor, Anna. “Heterogeneous metal-catalysed C-C coupling reactions : research and development : Réactions de couplage C-C réalisée par catalyse hétérogène : recherche et développement.” 2016. Doctoral Dissertation, Poitiers; Budapesti Műszaki és Gazdaságtudományi Egyetem (Budapest). Accessed October 16, 2019.
http://www.theses.fr/2016POIT2256.
MLA Handbook (7th Edition):
Fodor, Anna. “Heterogeneous metal-catalysed C-C coupling reactions : research and development : Réactions de couplage C-C réalisée par catalyse hétérogène : recherche et développement.” 2016. Web. 16 Oct 2019.
Vancouver:
Fodor A. Heterogeneous metal-catalysed C-C coupling reactions : research and development : Réactions de couplage C-C réalisée par catalyse hétérogène : recherche et développement. [Internet] [Doctoral dissertation]. Poitiers; Budapesti Műszaki és Gazdaságtudományi Egyetem (Budapest); 2016. [cited 2019 Oct 16].
Available from: http://www.theses.fr/2016POIT2256.
Council of Science Editors:
Fodor A. Heterogeneous metal-catalysed C-C coupling reactions : research and development : Réactions de couplage C-C réalisée par catalyse hétérogène : recherche et développement. [Doctoral Dissertation]. Poitiers; Budapesti Műszaki és Gazdaságtudományi Egyetem (Budapest); 2016. Available from: http://www.theses.fr/2016POIT2256
University of Alberta
13.
Lee, Jack C. H.
Preparation and Synthetic Applications of Chiral Alkyl
Boronates and Unsaturated Alkenyl Boronates.
Degree: PhD, Department of Chemistry, 2013, University of Alberta
URL: https://era.library.ualberta.ca/files/qn59q550n
► As Organic Chemistry evolves into the 21st Century, the goal of this discipline has altered dramatically from merely accessing target molecules to efficiently synthesizing these…
(more)
▼ As Organic Chemistry evolves into the 21st Century,
the goal of this discipline has altered dramatically from merely
accessing target molecules to efficiently synthesizing these
compounds with minimization of non-strategic functional group
manipulations and interconversions. Organoboron reagents represent
one of the potential solutions towards reaching this goal. These
versatile compounds can either be used to construct the desired
carbon−carbon bond through various cross-coupling reactions, or be
converted directly to the desired functionality through different
chemical reactions. Direct transformations make interconversions
between different functional groups unnecessary, thus making the
overall process step-economical. In this thesis, several synthetic
methods were developed to synthesize chiral alkyl boronates or
alkenyl boronates through metal-catalyzed chemical transformations.
These methodologies are based on early introduction strategy which
applies well-established synthetic protocols to substrates with a
pre-installed boronyl moiety. The subsequent applications of these
compounds were also investigated, leading to a variety of
synthetically valuable adducts. In order to access novel chiral
secondary alkyl boronates, catalytic asymmetric conjugate addition
reactions of 3-boronyl -unsaturated esters with Grignard
reagents were developed. Chapter 2 describes the details of
optimization of this methodology and the applications of the chiral
alkyl boronate products. Aiming to explore the intrinsic reactivity
of enantioenriched 1,1-diboron compounds, their synthesis was
accomplished for the first time by performing asymmetric conjugate
borylation on 3-boronyl enoates. The resulting optically enriched
1,1-diboron compounds were found to be excellent cross-coupling
partners in Suzuki-Miyaura cross-couplings, leading to chiral alkyl
boronates with excellent enantioselectivity. The details of these
studies are presented in Chapter 3. In order to conduct a thorough
examination of substrate scope in asymmetric conjugate reductions
of 3-boronyl-3-aryl -unsaturated esters, a diastereoselective
protocol for the preparation of these alkenyl boronates through
Heck coupling was developed. In Chapter 4, the optimization of the
coupling process, the substrate scope, and the subsequent
application of these alkenyl boronates are discussed. Due to the
synthetic potential of cyclic alkenyl boronates, new methods for
their efficient synthesis are desirable. In Chapter 5, the
preparation of novel cyclic alkenyl boronates through
gold-catalyzed enyne cycloisomerizations is
presented.
Subjects/Keywords: Gold-catalyzed cycloisomerization; Suzuki-Miyaura cross-coupling; Chiral alkyl boronates; Heck reaction; Enantioselective conjugate addition
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, J. C. H. (2013). Preparation and Synthetic Applications of Chiral Alkyl
Boronates and Unsaturated Alkenyl Boronates. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/qn59q550n
Chicago Manual of Style (16th Edition):
Lee, Jack C H. “Preparation and Synthetic Applications of Chiral Alkyl
Boronates and Unsaturated Alkenyl Boronates.” 2013. Doctoral Dissertation, University of Alberta. Accessed October 16, 2019.
https://era.library.ualberta.ca/files/qn59q550n.
MLA Handbook (7th Edition):
Lee, Jack C H. “Preparation and Synthetic Applications of Chiral Alkyl
Boronates and Unsaturated Alkenyl Boronates.” 2013. Web. 16 Oct 2019.
Vancouver:
Lee JCH. Preparation and Synthetic Applications of Chiral Alkyl
Boronates and Unsaturated Alkenyl Boronates. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2019 Oct 16].
Available from: https://era.library.ualberta.ca/files/qn59q550n.
Council of Science Editors:
Lee JCH. Preparation and Synthetic Applications of Chiral Alkyl
Boronates and Unsaturated Alkenyl Boronates. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/qn59q550n
Univerzitet u Beogradu
14.
Aleksić, Jovana. 1980-.
4-oksotiazolidin-2-alkiliden vinil-bromidi i α,
α-dibrom-2-metoksiacetofenon : prekursori u sintetički korisnim
transformacijama iniciranim retkim halofilnim napadom
nukleofila.
Degree: Hemijski fakultet, 2014, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:8119/bdef:Content/get
► Hemija - Organska hemija / Chemistry - Organic chemistry Datum odbrane: 8.03.2013.
Halofilne reakcije predstavljaju vrstu nukleofilnih supstitucionih reakcija do kojih dolazi kada nukleofil reaguje…
(more)
▼ Hemija - Organska hemija / Chemistry - Organic
chemistry Datum odbrane: 8.03.2013.
Halofilne reakcije predstavljaju vrstu nukleofilnih
supstitucionih reakcija do kojih dolazi kada nukleofil reaguje sa
atomom halogena, nakon ega se oslobaa karbanjon kao odlazea grupa.
To su relativno rijetke reakcije koje se dešavaju ukoliko je
klasina nukleofilna supstitucija (karbofilna reakcija) iz nekog
razloga otežana i/ili kada je karbanjon stabilizovan prisustvom
elektron-privlanih supstituenata. Cilj ovog rada je bio da se
ispitaju halofilne reakcije i njihova sintetika primena na dva
sistema: 2-alkiliden-4-oksotiazolidin vinil-bromidima i ,-dibrom-2-
metoksiacetofenonu. Znaaj ovih reakcija u sluaju ispitivanih
N-nesupstituisanih tiazolidinskih jedinjenja je u dobijanju novih,
potencijalno biološki aktivnih C-5 funkcionalizovanih derivata.
Ovakvi derivati se ne mogu dobiti direktno reakcionom sekvencom C-5
bromovanje/nukleofilna supstitucija, jer je bromovanje
Nnesupstituisanih 2-alkiliden-4-oksotiazolidina visoko
regioselektivno i kao proizvodi se dobijaju iskljuivo
vinil-bromidi. Znaaj prouavanja ovakvih reakcija u sluaju a,a-
dibrom-2-metoksiacetofenona proistie iz injenice da se selektivno
a- monobromovanje metil-ketona esto teško postiže, a praeno je
stvaranjem a,a-dibromderivata kao sporednih, a ponekad i kao
glavnih proizvoda. Mogua kaskadna halofilna/karbofilna reakcija bi
omoguila korišenje dibrom-derivata kao sintetikih ekvivalenta
monobromida, ime bi se izbegla dodatna faza selektivnog
debromovanja radi dobijanja monobrom-derivata, kao znaajnih
sintetikih intermedijera. Razliiti neutralni i anjonski nukleofili
su uestvovali u halofilnoj reakciji sa tiazolidinskim
vinilbromidima dajui tri vrste proizvoda: i) proizvod reduktivnog
debromovanja, ii) proizvod supstitucije broma i iii) C-5
funkcionalizovan proizvod. Takoe je pokazano da se
,-dibrom-2-metoksiacetofenon može upotrebiti kao sintetiki
ekvivalent a- monobromacetofenona. Pored navedenih halofilnih
reakcija, u ovom radu ispitivana je i mogunost izvoenja
Suzuki-Miyaura reakcije na vinil-bromidima, kao i mogua
regioselektivnost ove reakcije na N-supstituisanom tribrompirazolu,
a u cilju dobijanja novih, potencijalno biološki aktivnih
jedinjenja. Suzuki-Miyaura reakcija sa derivatima arilbornih
kiselina izvedena na vinil-bromidima nije dala oekivani rezultat,
ali je uspešno izvedena sa N-supstituisanim tribrompirazolima uz
visoku regioselektivnost, pri emu su sintetisani 5-supstituisani
3,4-dibrompirazoli sa 1,1 ekvivalentom arilbornih kiselina,
3,5-disupstituisani 4-brompirazoli sa 2,2 ekvivalenta arilbornih
kiselina i 3,4,5- trisupstituisani derivati sa 3,5 ekvivalenata
arilbornih kiselina. S obzirom da ispitivani tiazolidini spadaju u
grupu push-pull alkena, kod kojih elektronska delokalizacija izmeu
donorskih i akceptorskih grupa na dvostrukoj vezi ima znaajan
uticaj na njihove osobine i hemijsku reaktivnost, uraena je i
kvantifikacija push-pull efekta dvostruke veze.
Advisors/Committee Members: Baranac-Stojanović, Marija, 1971-.
Subjects/Keywords: halophilic reactions; vinyl halides;
; -dibromoacetophenones; Suzuki- Miyaura reaction; push-pull effect;
NBO analysis
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Aleksić, J. 1. (2014). 4-oksotiazolidin-2-alkiliden vinil-bromidi i α,
α-dibrom-2-metoksiacetofenon : prekursori u sintetički korisnim
transformacijama iniciranim retkim halofilnim napadom
nukleofila. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:8119/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Aleksić, Jovana 1980-. “4-oksotiazolidin-2-alkiliden vinil-bromidi i α,
α-dibrom-2-metoksiacetofenon : prekursori u sintetički korisnim
transformacijama iniciranim retkim halofilnim napadom
nukleofila.” 2014. Thesis, Univerzitet u Beogradu. Accessed October 16, 2019.
https://fedorabg.bg.ac.rs/fedora/get/o:8119/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Aleksić, Jovana 1980-. “4-oksotiazolidin-2-alkiliden vinil-bromidi i α,
α-dibrom-2-metoksiacetofenon : prekursori u sintetički korisnim
transformacijama iniciranim retkim halofilnim napadom
nukleofila.” 2014. Web. 16 Oct 2019.
Vancouver:
Aleksić J1. 4-oksotiazolidin-2-alkiliden vinil-bromidi i α,
α-dibrom-2-metoksiacetofenon : prekursori u sintetički korisnim
transformacijama iniciranim retkim halofilnim napadom
nukleofila. [Internet] [Thesis]. Univerzitet u Beogradu; 2014. [cited 2019 Oct 16].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:8119/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Aleksić J1. 4-oksotiazolidin-2-alkiliden vinil-bromidi i α,
α-dibrom-2-metoksiacetofenon : prekursori u sintetički korisnim
transformacijama iniciranim retkim halofilnim napadom
nukleofila. [Thesis]. Univerzitet u Beogradu; 2014. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:8119/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
15.
Huang, Hao-ping.
Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling.
Degree: Master, Chemistry, 2013, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051
► The direct ortho arylation of 4-methyl-N-phenylpyridin-2-amines via palladium(II)-catalyzed C-H activation is described. Treatment of 4-methyl-N-phenylpyridin-2-amine with potassium aryltrifluoroborate using ten mol % of Pd(OAc)2 as…
(more)
▼ The direct ortho arylation of 4-methyl-N-phenylpyridin-2-amines via palladium(II)-catalyzed C-H activation is described. Treatment of 4-methyl-N-phenylpyridin-2-amine with potassium aryltrifluoroborate using ten mol % of Pd(OAc)2 as the catalyst, two equivalents of copper (II) acetate as the oxidant and one equivalent of p-benzoquinone in tert-butyl alcohol gave the ortho-arylated products in modest to excellent yields. This
reaction shows good functional group compatibility. A series of controlled experiments and 1H NMR titration experiments for the
reaction were carried out. The key intermediate, 4-methyl-N-phenylpyridin-2-amine palladacycle was isolated and characterized by X-ray crystallography. A rational mechanism for the catalytic
reaction is presented. The advanced transformations of ortho phenylated 4-methyl-N-phenylpyridin-2-amine to N-(4-methylpyridine-2-yl)-9H-carbazole, biphenyl-2-amine, and 3-methyl-6-phenylpyrido[1,2-a]-benzimidazole were successfully demonstrated.
Advisors/Committee Members: Jen-Chieh Hsieh (chair), Ming-Jung Wu (committee member), Po-Chiao Lin (chair).
Subjects/Keywords: palladium; C-H bond activation; potassium aryltrifluoroborate; Suzuki-Miyaura cross-coupling reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Huang, H. (2013). Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Huang, Hao-ping. “Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling.” 2013. Thesis, NSYSU. Accessed October 16, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Huang, Hao-ping. “Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling.” 2013. Web. 16 Oct 2019.
Vancouver:
Huang H. Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling. [Internet] [Thesis]. NSYSU; 2013. [cited 2019 Oct 16].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Huang H. Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
16.
Wu, Chung-chiu.
Palladium (II)-Catalyzed Ortho Arylation of 9-(Pyridin-2-yl)-9H-carbazoles via C-H Bond Activation And Mechanistic Investigation.
Degree: Master, Chemistry, 2012, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0709112-170941
► A one-pot synthesis of ortho-arylated 9-(pyridin-2-yl)-9H-carbazoles via C-H bond activation, in which palladium(II)-catalyzed cross-coupling of 9-(pyridin-2-yl)-9H-carbazoles with potassium aryltrifluoroborates is presented. Silver nitrate and tert-butanol…
(more)
▼ A one-pot synthesis of ortho-arylated 9-(pyridin-2-yl)-9H-carbazoles via C-H bond activation, in which palladium(II)-catalyzed cross-coupling of 9-(pyridin-2-yl)-9H-carbazoles with potassium aryltrifluoroborates is presented. Silver nitrate and tert-butanol were proved to be the best oxidant and solvent for the process, respectively. The product yields fluctuated from modest to excellent, and the
reaction showed sufficient functional group tolerance. p-Benzoquinone served as an important ligand for the transmetalation and reductive elimination steps in the catalytic process. The key intermediate of the
reaction, 9-(pyridin-2-yl)-9H-carbazole palladacycle was isolated and confirmed by X-ray crystallography. The kinetic isotope effect (kH/kD) for the C-H bond activation step was measured as 0.87. In addition, Hammett experiment gave a negative rho value, -2.14 with a reasonable correlation (R2 = 0.90). The directing group, pyridyl was demonstrated as a removable functional group. Finally, a rational catalytic mechanism is presented based on all experimental evidence.
Advisors/Committee Members: Jen-Chieh Hsieh (chair), Ming-Jung Wu (committee member), Michael Y. Chiang (chair).
Subjects/Keywords: potassium aryltrifluoroborate; palladium catalysis; C-H bond activation; carbazole; Suzuki-Miyaura coupling reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wu, C. (2012). Palladium (II)-Catalyzed Ortho Arylation of 9-(Pyridin-2-yl)-9H-carbazoles via C-H Bond Activation And Mechanistic Investigation. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0709112-170941
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wu, Chung-chiu. “Palladium (II)-Catalyzed Ortho Arylation of 9-(Pyridin-2-yl)-9H-carbazoles via C-H Bond Activation And Mechanistic Investigation.” 2012. Thesis, NSYSU. Accessed October 16, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0709112-170941.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wu, Chung-chiu. “Palladium (II)-Catalyzed Ortho Arylation of 9-(Pyridin-2-yl)-9H-carbazoles via C-H Bond Activation And Mechanistic Investigation.” 2012. Web. 16 Oct 2019.
Vancouver:
Wu C. Palladium (II)-Catalyzed Ortho Arylation of 9-(Pyridin-2-yl)-9H-carbazoles via C-H Bond Activation And Mechanistic Investigation. [Internet] [Thesis]. NSYSU; 2012. [cited 2019 Oct 16].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0709112-170941.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wu C. Palladium (II)-Catalyzed Ortho Arylation of 9-(Pyridin-2-yl)-9H-carbazoles via C-H Bond Activation And Mechanistic Investigation. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0709112-170941
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Virginia Commonwealth University
17.
Yang, Yuan.
Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions.
Degree: PhD, Engineering, 2018, Virginia Commonwealth University
URL: https://scholarscompass.vcu.edu/etd/5488
► Palladium-catalyzed carbon-carbon cross-coupling reactions have emerged a broadly useful, selective and widely applicable method to synthesize pharmaceutical active ingredients. As currently practiced in the…
(more)
▼ Palladium-catalyzed carbon-carbon cross-coupling reactions have emerged a broadly useful, selective and widely applicable method to synthesize pharmaceutical active ingredients. As currently practiced in the pharmaceutical industry, homogeneous Pd catalysts are typically used in cross-coupling reactions. The rational development of heterogeneous catalysts for cross-coupling reactions is critical for overcoming the major drawbacks of homogeneous catalysis including difficulties in the separation, purification, and quality control process in drug production. In order to apply heterogeneous catalysis to flow reactors that may overcome this limitation, the catalyst must be strongly bound to a support, highly stable with respect to leaching, and highly active. While the primary role of supports in catalysis has been to anchor metal particles to prevent sintering and leaching, supports can also activate catalytic processes. In this study, by using a xi combined theoretical and experimental method, we probed the effect of graphene as support in the complex
reaction cycle of
Suzuki reactions. The density functional theory study provides a fundamental understanding of how a graphene support strongly binds the Pd nanoparticles and act as both an efficient charge donor and acceptor in oxidation and reduction
reaction steps. Theoretical investigations prove that the Pd-graphene interaction promotes electron flow between the metal cluster and the defected graphene to reduce
reaction barrier. The ability for graphene to both accept and donate charge makes graphene an unusually suitable support for multi-step catalytic processes that involve both oxidation and reduction steps. The computer-aided catalyst design with the atomic precise accuracy demonstrates the Pd/graphene catalyst can be further optimized and the first-row transition metal nanoparticles have great potential to replace Pd to catalyze the
Suzuki reaction. The corresponding experimental study shows that the method to immobilize the Pd nanoparticles on the graphene is crucial to increasing the reactivity and stability of the resulted catalyst. A comparison of the activation energy and turn over frequency for a series of supported and homogeneous catalysts indicates that exposing palladium-graphene to defect inducing microwave radiation results in dramatically lower activation energies and higher turnover frequencies. Furthermore, the heterogeneity tests demonstrate the
Suzuki reactions are carried out on the surface of the immobilized Pd nanoparticle agreeing with the theoretical results. A method to engineer the 2-D graphene support to a 3-D structure to minimize the re-stacking and agglomeration of the graphene lattice will also be introduced in this study.
Advisors/Committee Members: Frank Gupton, Arthur Reber, Shiv Khanna, Christina Tang, Stephen Fong.
Subjects/Keywords: Graphene Nanocatalysis heterogeneous Suzuki Palladium; Catalysis and Reaction Engineering; Nanoscience and Nanotechnology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yang, Y. (2018). Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions. (Doctoral Dissertation). Virginia Commonwealth University. Retrieved from https://scholarscompass.vcu.edu/etd/5488
Chicago Manual of Style (16th Edition):
Yang, Yuan. “Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions.” 2018. Doctoral Dissertation, Virginia Commonwealth University. Accessed October 16, 2019.
https://scholarscompass.vcu.edu/etd/5488.
MLA Handbook (7th Edition):
Yang, Yuan. “Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions.” 2018. Web. 16 Oct 2019.
Vancouver:
Yang Y. Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions. [Internet] [Doctoral dissertation]. Virginia Commonwealth University; 2018. [cited 2019 Oct 16].
Available from: https://scholarscompass.vcu.edu/etd/5488.
Council of Science Editors:
Yang Y. Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions. [Doctoral Dissertation]. Virginia Commonwealth University; 2018. Available from: https://scholarscompass.vcu.edu/etd/5488
Virginia Commonwealth University
18.
Brinkley, Kendra W.
The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions.
Degree: PhD, Engineering, 2015, Virginia Commonwealth University
URL: https://scholarscompass.vcu.edu/etd/3959
► Catalysis is one of the pillars of the chemical industry. While the use of catalyst is typically recognized in the automobile industry, their impact…
(more)
▼ Catalysis is one of the pillars of the chemical industry. While the use of catalyst is typically recognized in the automobile industry, their impact is more widespread as; catalysts are used in the synthesis of 80% of the US commercial chemicals. Despite the improved selectivity provided by catalyst, process inefficiencies still threaten the sustainability of a number of synthesis methods, especially in the pharmaceutical industry. Recyclable solid supported catalysts offer a unique opportunity to address these inefficiencies. Such systems coupled with continuous synthesis techniques, have the potential to significantly reduce the waste to desired product ratio (E-factor) of the production techniques. This research focuses developing sustainable processes to synthesize organic molecules by using continuous synthesis methods. In doing so, solid supported metal catalyst systems were identified, developed, and implemented to assist in the formation of carbon-carbon bonds. Newly developed systems, which utilized metal nanoparticles, showed reactivity and recyclability, comparable to commercially available catalyst.
Nanoparticles are emerging as useful materials in a wide variety of applications including catalysis. These applications include pharmaceutical processes by which complex and useful organic molecules can be prepared. As such, an effective and scalable synthesis method is required for the preparation of nanoparticle catalysts with significant control of the particle size, uniform dispersion, and even distribution of nanoparticles when deposited on the surface of a solid support. This project describes the production of palladium nanoparticles on a variety of solid supports and the evaluation of these nanoparticles for cross coupling reactions.
This report highlights novel synthesis techniques used in the formation of palladium nanoparticles using traditional batch reactions. The procedures developed for the batch formation of palladium nanoparticles on different solid supports, such as graphene and carbon nanotubes, are initially described. The major drawbacks of these methods are discussed, including limited scalability, variation of nanoparticle characteristics from batch to batch, and technical challenges associated with efficient heating of samples.
Furthermore, the necessary conditions and critical parameters to convert the batch synthesis of solid supported palladium nanoparticles to a continuous flow process are presented. This strategy not only alleviates the challenges associated with the robust preparation of the material and the limitations of scalability, but also showcases a new continuous reactor capable of efficient and direct heating of the
reaction mixture under microwave irradiation. This strategy was further used in the synthesis of zinc oxide nanoparticles. Particles synthesized using this strategy as well as traditional synthesis methods, were evaluated in the context industrially relevant applications.
Advisors/Committee Members: Dr. B.F. Gupton.
Subjects/Keywords: Palladium nanoparticles; Suzuki Reaction; graphene; Catalysis; Continuous Reactions; Carbon nanotubes; Catalysis and Reaction Engineering; Process Control and Systems
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brinkley, K. W. (2015). The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions. (Doctoral Dissertation). Virginia Commonwealth University. Retrieved from https://scholarscompass.vcu.edu/etd/3959
Chicago Manual of Style (16th Edition):
Brinkley, Kendra W. “The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions.” 2015. Doctoral Dissertation, Virginia Commonwealth University. Accessed October 16, 2019.
https://scholarscompass.vcu.edu/etd/3959.
MLA Handbook (7th Edition):
Brinkley, Kendra W. “The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions.” 2015. Web. 16 Oct 2019.
Vancouver:
Brinkley KW. The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions. [Internet] [Doctoral dissertation]. Virginia Commonwealth University; 2015. [cited 2019 Oct 16].
Available from: https://scholarscompass.vcu.edu/etd/3959.
Council of Science Editors:
Brinkley KW. The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions. [Doctoral Dissertation]. Virginia Commonwealth University; 2015. Available from: https://scholarscompass.vcu.edu/etd/3959
University of Victoria
19.
Yunker, Lars Peter Erasmus.
Real-time mass spectrometric analysis of catalytic reaction mechanisms.
Degree: Department of Chemistry, 2017, University of Victoria
URL: http://hdl.handle.net/1828/8029
► Mass spectrometry was used to study two disparate transformations: in an applied project, the supposed degradation of perfluorooctanesulfonate (PFOS); and in a fundamental study, the…
(more)
▼ Mass spectrometry was used to study two disparate transformations: in an applied project, the supposed degradation of perfluorooctanesulfonate (PFOS); and in a fundamental study, the
Suzuki-Miyaura (SM)
reaction was investigated in detail. The first investigation revealed that published methods to degrade PFOS were ineffectual, with apparent decreases being associated with adsorption onto available surfaces. In the
Suzuki-Miyaura
reaction, a dynamic series of equilibria were observed, and there is no direct evidence of a single pathway. Instead, there appear to be two mechanisms which are active in different conditions (one fluoride, one aqueous). Studies were initiated into the related SM polycondensation
reaction and the hydrolysis of aryltrifluoroborates, the former indicating a step-growth mechanism, and the latter indicating a dynamic series of equilibria which are very sensitive to experimental conditions. Processing and interpretation of mass spectrometric data was a significant part of all of these projects, so a python framework was developed to assist in these tasks and its features are also documented herein.
Advisors/Committee Members: McIndoe, J. Scott (supervisor).
Subjects/Keywords: Mass spectrometry; Suzuki-Miyaura; online reaction monitoring; electrospray ionization; ESI-MS; perfluorooctane sulfonate; PFOS; transmetallation mechanism; trifluoroborate hydrolysis; suzuki polycondensation; python; MSPT; pressurized sample infusion
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yunker, L. P. E. (2017). Real-time mass spectrometric analysis of catalytic reaction mechanisms. (Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/8029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yunker, Lars Peter Erasmus. “Real-time mass spectrometric analysis of catalytic reaction mechanisms.” 2017. Thesis, University of Victoria. Accessed October 16, 2019.
http://hdl.handle.net/1828/8029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yunker, Lars Peter Erasmus. “Real-time mass spectrometric analysis of catalytic reaction mechanisms.” 2017. Web. 16 Oct 2019.
Vancouver:
Yunker LPE. Real-time mass spectrometric analysis of catalytic reaction mechanisms. [Internet] [Thesis]. University of Victoria; 2017. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/1828/8029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yunker LPE. Real-time mass spectrometric analysis of catalytic reaction mechanisms. [Thesis]. University of Victoria; 2017. Available from: http://hdl.handle.net/1828/8029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universitat de Girona
20.
Cerezo Frias, Vanessa.
Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines.
Degree: Departament de Química, 2009, Universitat de Girona
URL: http://hdl.handle.net/10803/8054
► Biaryl amino acids are present in a great variety of natural peptides which display important biological activities. In particular, arylhistidines naturally occur in cytotoxic and…
(more)
▼ Biaryl amino acids are present in a great variety of natural peptides which display important biological activities. In particular, arylhistidines naturally occur in cytotoxic and antifungal marine peptides, aciculitins. The
Suzuki-Miyaura cross-coupling is the most versatile method to obtain unsymmetrical biaryls. Up to now, it had not been applied to the arylation of the histidine imidazole ring. The main objective of this thesis was to demonstrate that a
Suzuki-Miyaura
reaction was amenable to solid-phase arylation of the histidine imidazole ring. Firstly, it was synthesized 4(5)-methyl-5(4)-phenylimidazole and 4(5)-methyl-5(4)-(2-methoxyphenyl)imidazole by cross-coupling between N-benzylbromoimidazole and the corresponding arylboronic acid. Secondly, 5-bromohistidines were arylated with several arylboronic acids by a microwave-assisted
Suzuki-Miyaura cross-coupling
reaction in solution as well as solid-phase leading to the corresponding arylhistidines. Finally, antimicrobial peptides containing 5-arylhistidines were prepared using the previous methodology. They showed activity against gram-negative bacteria responsible of important plant diseases such as fire blight.
Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Feliu Soley, Lídia (director), Planas i Grabuleda, Marta (director).
Subjects/Keywords: Microwaves; Microondas; Microones; Solid-phase; Fase solida; Péptidos; Peptides; Pèptids; Biaryl amino acids; Aminoácidos biarílicos; Aminoàcids biarílics; Reacción Suzuki-Miyaura; Suzuki-Miyaura reaction; Reacció Suzuku-Miyaura; Arylhistidines; Arilhistidines; 547
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cerezo Frias, V. (2009). Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines. (Thesis). Universitat de Girona. Retrieved from http://hdl.handle.net/10803/8054
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cerezo Frias, Vanessa. “Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines.” 2009. Thesis, Universitat de Girona. Accessed October 16, 2019.
http://hdl.handle.net/10803/8054.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cerezo Frias, Vanessa. “Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines.” 2009. Web. 16 Oct 2019.
Vancouver:
Cerezo Frias V. Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines. [Internet] [Thesis]. Universitat de Girona; 2009. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/10803/8054.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cerezo Frias V. Síntesi de base sòlida de pèptids biarílics contenint 5-arilhistidines. [Thesis]. Universitat de Girona; 2009. Available from: http://hdl.handle.net/10803/8054
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
D'Attoma, Joseph.
Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction.
Degree: Docteur es, Chimie, 2013, Université Claude Bernard – Lyon I
URL: http://www.theses.fr/2013LYO10243
► Les lymphomes à grandes cellules anaplasiques ou ALCL (Anaplastic Large-Cell Lymphoma) sont des cancers appartenant à la famille des lymphomes de type non-Hodgkin. La majorité…
(more)
▼ Les lymphomes à grandes cellules anaplasiques ou ALCL (Anaplastic Large-Cell Lymphoma) sont des cancers appartenant à la famille des lymphomes de type non-Hodgkin. La majorité des ALCL est issue d'une translocation t(2;5)(p23;q35) donnant lieu à la formation d'une protéine de fusion appelée NPM-ALK. A ce jour, peu d'inhibiteurs présentent de bonnes activités contre cette protéine chimérique. L'obésité représente un problème socio-médical d'envergure, à la fois pour ses effets directs et indirects ; le surpoids étant un facteur primaire dans de nombreuses maladies, tout particulièrement les diabètes, les accidents cardiovasculaires, le cancer, etc. A contrario, une restriction calorique (RC) est associée à des bénéfices importants en terme de santé. A l'issue de plusieurs criblages, un inhibiteur au motif 2-acylaminothiazole a montré une activité anticancéreuse sur ALK mais également la faculté de mimer la restriction calorique chez C. Elegans. Par conséquent, les travaux de recherche réalisés lors de cette thèse ont concerné la synthèse d'inhibiteurs comportant le squelette 2-acylaminothiazole. Les chromatographies d'affinité effectuées sur deux de nos inhibiteurs ont permis l'identification de cibles principales potentielles dans le cadre de la restriction calorique et des cibles secondaires possibles pour NPM-ALK. Ensuite, la présence d'un atome de brome sur le cycle aromatique a mené à la formation de liaisons C(sp2)-C(sp2), C(sp2)-C(sp) et C(sp2)- N, en utilisant les couplages catalysés par le palladium. Les différentes méthodes de modulation chimique ont conduit à mettre en place une librairie de 134 molécules. Certains d'entres eux et plus précisément ceux possédant un atome de silicium ont démontré une très bonne activité contre ALK et son mutant L1196M. Enfin, des résultats préliminaires ont également été obtenus sur le sujet de la restriction calorique avec quatre composés montrant une réduction du taux de lipides chez C. Elegans
Anaplastic Large-Cell Lymphoma (ALCL) is a type of cancer belonging to the non-Hodgkin family. The majority of ALCL arises from a translocation t(2;5) (p23;35) which leads to the formation of a fusion protein called NPM-ALK. Nowadays, few molecules are known to inhibit the activity of this chimeric protein. Obesity is a major socio-medical problem, for both direct and indirect effects, overweight is a primary factor in many diseases, especially diabetes, cardiovascular events, cancer, etc... In contrast, caloric restriction (CR) is associated with significant benefits in terms of health. After several screenings, one inhibitor based on a 2-acylaminothiazol scaffold showed anticancer activity on the protein ALK but also the ability to mimic caloric restriction in C. Elegans. The aim of this PhD was to develop the synthesis of new inhibitors including the 2-acylaminothiazol scaffold. The affinity chromatography performed on two of our inhibitors was used to identify potential major cellular targets in the process of caloric restriction and secondary cellular targets for NPM-ALK.…
Advisors/Committee Members: Goekjian, Peter (thesis director).
Subjects/Keywords: 2-acylaminothiazoles; Restriction calorique; ALCL; NPM-ALK; Réaction de Suzuki- Miyaura; Réaction de Buchwald-Hartwig; Réaction de Sonogashira; 2-acylaminothiazols; Caloric restriction; ALCL; NPM-ALK; Suzuki-Miyaura crosscoupling reaction; Buchwald-Hartwig cross-coupling reaction; Sonogashira cross-coupling reaction; 547
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
D'Attoma, J. (2013). Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2013LYO10243
Chicago Manual of Style (16th Edition):
D'Attoma, Joseph. “Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction.” 2013. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed October 16, 2019.
http://www.theses.fr/2013LYO10243.
MLA Handbook (7th Edition):
D'Attoma, Joseph. “Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction.” 2013. Web. 16 Oct 2019.
Vancouver:
D'Attoma J. Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2013. [cited 2019 Oct 16].
Available from: http://www.theses.fr/2013LYO10243.
Council of Science Editors:
D'Attoma J. Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2013. Available from: http://www.theses.fr/2013LYO10243
NSYSU
22.
Li, Yi-wei.
Aggregation-Induced Emission Enhancement of organic and polymeric fluorophores containing 2,4,6-Triphenylpyridine moiety.
Degree: Master, Materials and Optoelectronic Science, 2012, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0713112-173820
► In this study, organic and polymeric fluorophores based on 2,4,6-triphenylpyridiene (TPP) structure were found to have the novel aggregation-induced emission enhancement (AIEE) property. For the…
(more)
▼ In this study, organic and polymeric fluorophores based on 2,4,6-triphenylpyridiene (TPP) structure were found to have the novel aggregation-induced emission enhancement (AIEE) property. For the small-mass fluorophores, TPP and cyano-functionalized TPP (TPP-CN) were prepared from the facile Chichibabin
reaction and their AIEE properties were characterized by the emission behavior in solvent/nonsolvent pair. Solid samples of TPP and TPP-CN exhibit enhanced emission with increasing annealing time under solvent vapors, thus, both compounds have the characters of crystallization-induced emission enhancement (CIEE) behavior. For polymeric system, copolymers PTPPF containing alternative TPP and 9,9-dioctylfluorene units were prepared through
Suzuki coupling and study on its fluorescence behavior also reveals its AIEE feature. The rigid polymer possesses high emission intensity in its dilute solution state and remains almost unchanged with increasing nonsolvent fraction. The solid sample was found to have a high quantum yield (ФF) of 70 %.
Advisors/Committee Members: Ming Chen (chair), Shiao-wei Kuo (chair), Lieh-Li Lin (chair), Jin-long Hong (committee member).
Subjects/Keywords: 6-triphenylpyridiene; 4; quantum yield (ФF); suzuki coupling; 2; Chichibabin reaction; aggregation-induced emission enhancement (AIEE); crystallization-induced emission enhancement (CIEE)
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Li, Y. (2012). Aggregation-Induced Emission Enhancement of organic and polymeric fluorophores containing 2,4,6-Triphenylpyridine moiety. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0713112-173820
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Li, Yi-wei. “Aggregation-Induced Emission Enhancement of organic and polymeric fluorophores containing 2,4,6-Triphenylpyridine moiety.” 2012. Thesis, NSYSU. Accessed October 16, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0713112-173820.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Li, Yi-wei. “Aggregation-Induced Emission Enhancement of organic and polymeric fluorophores containing 2,4,6-Triphenylpyridine moiety.” 2012. Web. 16 Oct 2019.
Vancouver:
Li Y. Aggregation-Induced Emission Enhancement of organic and polymeric fluorophores containing 2,4,6-Triphenylpyridine moiety. [Internet] [Thesis]. NSYSU; 2012. [cited 2019 Oct 16].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0713112-173820.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Li Y. Aggregation-Induced Emission Enhancement of organic and polymeric fluorophores containing 2,4,6-Triphenylpyridine moiety. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0713112-173820
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
23.
贾, 吉祥.
Development of highly effective reaction system using supported Pd catalysts for the Suzuki-Miyaura coupling of bromobenzene and chlorobenzene with phenylboronic acid.
Degree: Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学
URL: http://hdl.handle.net/10119/11940
Supervisor:海老谷 幸喜
マテリアルサイエンス研究科
修士
Subjects/Keywords: Suzuki-Miyaura coupling reaction; Palladium; Hydrotalcite; Mgnesium hydroxide; Surfactant
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
贾, . (n.d.). Development of highly effective reaction system using supported Pd catalysts for the Suzuki-Miyaura coupling of bromobenzene and chlorobenzene with phenylboronic acid. (Thesis). Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10119/11940
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
贾, 吉祥. “Development of highly effective reaction system using supported Pd catalysts for the Suzuki-Miyaura coupling of bromobenzene and chlorobenzene with phenylboronic acid.” Thesis, Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学. Accessed October 16, 2019.
http://hdl.handle.net/10119/11940.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
贾, 吉祥. “Development of highly effective reaction system using supported Pd catalysts for the Suzuki-Miyaura coupling of bromobenzene and chlorobenzene with phenylboronic acid.” Web. 16 Oct 2019.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
贾 . Development of highly effective reaction system using supported Pd catalysts for the Suzuki-Miyaura coupling of bromobenzene and chlorobenzene with phenylboronic acid. [Internet] [Thesis]. Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学; [cited 2019 Oct 16].
Available from: http://hdl.handle.net/10119/11940.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
贾 . Development of highly effective reaction system using supported Pd catalysts for the Suzuki-Miyaura coupling of bromobenzene and chlorobenzene with phenylboronic acid. [Thesis]. Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学; Available from: http://hdl.handle.net/10119/11940
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
University of the Western Cape
24.
Ramoroka, Morongwa Emmanuel.
Photophysics of Thiophenosalicylaldimine-functionalized G1-Polyprolyleniminato-Copper Telluride/Antimonide core-shell Nanomaterials
.
Degree: 2018, University of the Western Cape
URL: http://hdl.handle.net/11394/6262
► This work involves the synthesis of copper telluride-polypropylenimine tetra(5-(2-thienyl) salicylaldimine) (
[email protected]) and copper antimonide-polypropylenimine tetra(5-(2-thienyl) salicylaldimine) (
[email protected]) core-shell nanoparticles (NPs), using two-pots and one-pot synthesis…
(more)
▼ This work involves the synthesis of copper telluride-polypropylenimine tetra(5-(2-thienyl)
salicylaldimine) (
[email protected]) and copper antimonide-polypropylenimine tetra(5-(2-thienyl)
salicylaldimine) (
[email protected]) core-shell nanoparticles (NPs), using two-pots and one-pot
synthesis methods, respectively. Their morphology was studied by X-ray diffraction
spectroscopy (XRD), high resolution transmission electron microscopy (HRTEM) and high
resolution scanning electron microscopy (HRSEM); while their structures were characterized by
Fourier transform infrared spectroscopy (FTIR) and elemental analysis. Photophysical properties
of the core-shell NPs were determined from ultraviolet-visible absorption spectroscopy (UV-Vis)
and photoluminescence spectroscopy (PL). For core-shell NPs produced via two-pots method
only
[email protected] exhibited ? ? ?* and n ? ?* which indicate that
[email protected] produced via
two-pots method was unsuccessfully synthesized. The ? ? ?* and n ? ?* transitions indicate
the presence of polypropylenimine tetra(5-(2-thienyl) salicylaldimine) (PPI) on the surface of
CuTe NPs and CuSb NPs. FTIR confirmed coordination of PPI on the surface of CuTe NPs and
CuSb NPs by showing a shift in wavenumber of C=N group bands from PPI. HR-TEM showed
that the
[email protected] synthesized via one-pot method have a wide particles sizes distribution with
an average particles size of 13.60 nm while for
[email protected] synthesized via two-pots it was
impossible to determine the particles size due to aggregation.
[email protected] synthesized via twopots
method and one-pot method has a wide particles sizes distribution with an average size of
7.98 nm and 11.61 nm respectively. The average particles sizes determined by HR-SEM were
found to be 35.24 nm (
[email protected] two-pots method), 33.90 nm (
[email protected] one-pot method),
18.30 nm (
[email protected] two-pots method), and 16.18 nm (
[email protected] one pot method).
Advisors/Committee Members: Iwuoha, Emmanuel I (advisor).
Subjects/Keywords: Bimetallic nanoparticles; Metal-chalcogenides nanoparticles; Dendrimers; Core-shell nanoparticles; Photophysics; Photovoltaics; Electrochemical characterization; Schiff base condensation; Chemical reduction; Suzuki coupling reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ramoroka, M. E. (2018). Photophysics of Thiophenosalicylaldimine-functionalized G1-Polyprolyleniminato-Copper Telluride/Antimonide core-shell Nanomaterials
. (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6262
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ramoroka, Morongwa Emmanuel. “Photophysics of Thiophenosalicylaldimine-functionalized G1-Polyprolyleniminato-Copper Telluride/Antimonide core-shell Nanomaterials
.” 2018. Thesis, University of the Western Cape. Accessed October 16, 2019.
http://hdl.handle.net/11394/6262.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ramoroka, Morongwa Emmanuel. “Photophysics of Thiophenosalicylaldimine-functionalized G1-Polyprolyleniminato-Copper Telluride/Antimonide core-shell Nanomaterials
.” 2018. Web. 16 Oct 2019.
Vancouver:
Ramoroka ME. Photophysics of Thiophenosalicylaldimine-functionalized G1-Polyprolyleniminato-Copper Telluride/Antimonide core-shell Nanomaterials
. [Internet] [Thesis]. University of the Western Cape; 2018. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/11394/6262.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ramoroka ME. Photophysics of Thiophenosalicylaldimine-functionalized G1-Polyprolyleniminato-Copper Telluride/Antimonide core-shell Nanomaterials
. [Thesis]. University of the Western Cape; 2018. Available from: http://hdl.handle.net/11394/6262
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universitat de Girona
25.
Afonso Afonso, Ana.
Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana.
Degree: Departament de Química, 2011, Universitat de Girona
URL: http://hdl.handle.net/10803/38882
► The present PhD study was focused on the preparation of biaryl peptides on solid-phase. First, phenylalanine or tyrosine residues were borylated through a Miyaura reaction.…
(more)
▼ The present PhD study was focused on the preparation of biaryl peptides on solid-phase. First, phenylalanine or tyrosine residues were borylated through a Miyaura
reaction. Then, the resulting boronates were arylated via a
Suzuki-Miyaura
reaction under microwave irradiation, using a range of aryl halides and haloamino acids. This methodology was extended to the solid-phase synthesis of biaryl cyclic peptides. This strategy is advantageous because it avoids the synthesis and purification of amino acid boronates in solution. Moreover, it allows the preparation of a large diversity of biaryl peptides from a single boronopeptide intermediate. The evaluation of the biological activity allowed the identification of active sequences against the economically important plant pathogenic bacteria Erwinia amylovora, Xanthomonas vesicatoria, and Pseudomonas syringae, and moreover they were not toxic against eukaryotic cells.
Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Planas i Grabuleda, Marta (director), Feliu Soley, Lídia (director), true (authorsendemail).
Subjects/Keywords: Pèptids biarílics; Biaryl peptides; Péptidos biarílicos; Pèptids antimicrobials; Antimicrobial peptides; Péptidos antimicrobianos; Irradiació de microones; Microwave irradiation; Irradiación de microondas; Fase sòlida; Solid-phase; Fase sólida; Borilació; Borilation; Borilación; Reacció de Suzuki-Miyaura; Suzuki-Miyaura reaction; Reacción de Suzuki-Miyaura; 547
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Afonso Afonso, A. (2011). Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana. (Thesis). Universitat de Girona. Retrieved from http://hdl.handle.net/10803/38882
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Afonso Afonso, Ana. “Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana.” 2011. Thesis, Universitat de Girona. Accessed October 16, 2019.
http://hdl.handle.net/10803/38882.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Afonso Afonso, Ana. “Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana.” 2011. Web. 16 Oct 2019.
Vancouver:
Afonso Afonso A. Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana. [Internet] [Thesis]. Universitat de Girona; 2011. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/10803/38882.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Afonso Afonso A. Pèptids biarílics a partir de 4-iodofenilalanina o 3-iodotirosina per borilació i reacció de Suzuki-Miyaura en fase sòlida. Avaluació de l'activitat antimicrobiana. [Thesis]. Universitat de Girona; 2011. Available from: http://hdl.handle.net/10803/38882
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universitat de Girona
26.
Ng Choi, I-teng Montserrat.
Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins.
Degree: Departament de Química, 2015, Universitat de Girona
URL: http://hdl.handle.net/10803/380739
► La incorporació de sistemes biarílics asimiètrics en seqüències peptídiques es considera un enfocament útil per a millorar l'activitat biològica de pèptids. Tenint en compte la…
(more)
▼ La incorporació de sistemes biarílics asimiètrics en seqüències peptídiques es considera un enfocament útil per a millorar l'activitat biològica de pèptids. Tenint en compte la dificultat d'arilar la posició 4 (5) de l'anell d'imidazole, aquesta tesi doctoral es centra en el desenvolupament de noves estratègies eficients per a la preparació en fase sòlida d'undecapèptids antimicrobians contenint una 5-arilhistidina a través d'una reacció de
Suzuki-Miyaura sota irradiació microones. L'extensió d'aquesta metodologia ha permès la síntesi de pèptids biarílics cíclics de diferents mides que incorporen un enllaç His-Phe 0 His-Tyr. Posteriorment, s'ha desenvolupat un procediment per la síntesi total en fase sòlida de lipopèptids biarílics cíclics derivats de les arilomicines. Les estratègies anteriors s'han estès a la preparació de compostos biarílics anàlegs dels pèptids bicíclics marins aciculitines. Concretament, s'ha preparat anàlegs dels hemisferis nord i sud de las aciculitines així com pèptids biarílics bicíclics que incorporen un pont Phe-Phe, Phe-Tyr, Tyr-His 0 Tyr-Tyr.
Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Planas i Grabuleda, Marta (director), Feliu Soley, Lídia (director), true (authorsendemail).
Subjects/Keywords: Histidine; Histidina; Biaryl peptides; Pèptids biarílics; Péptidos biarílicos; Microwave irradiation; Irradiació de microones; Irradiación de microondas; Macroarylation; Macroarilació; Macroarilación; Arylomycins; Arilomicines; Arilomicinas; Suzuki-Miyaura reaction; Reacción Suzuki-Miyaura; Reacció Suzuki-Miyaura; 547
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ng Choi, I. M. (2015). Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins. (Thesis). Universitat de Girona. Retrieved from http://hdl.handle.net/10803/380739
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ng Choi, I-teng Montserrat. “Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins.” 2015. Thesis, Universitat de Girona. Accessed October 16, 2019.
http://hdl.handle.net/10803/380739.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ng Choi, I-teng Montserrat. “Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins.” 2015. Web. 16 Oct 2019.
Vancouver:
Ng Choi IM. Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins. [Internet] [Thesis]. Universitat de Girona; 2015. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/10803/380739.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ng Choi IM. Solid-phase synthesis of 5-arylhistidine-containing peptides: from linear antimicrobial peptides to cyclic peptides derived from arylomycins and aciculitins. [Thesis]. Universitat de Girona; 2015. Available from: http://hdl.handle.net/10803/380739
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
27.
Bauer, John C.
Nanoparticles as Reactive Precursors: Synthesis of Alloys, Intermetallic Compounds, and Multi-Metal Oxides Through Low-Temperature Annealing and Conversion Chemistry.
Degree: 2010, Texas A&M University
URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-642
► Alloys, intermetallic compounds and multi-metal oxides are generally made by traditional solid-state methods that often require melting or grinding/pressing powders followed by high temperature annealing…
(more)
▼ Alloys, intermetallic compounds and multi-metal oxides are generally made by
traditional solid-state methods that often require melting or grinding/pressing powders
followed by high temperature annealing (> 1000 degrees C) for days or weeks. The research
presented here takes advantage of the fact that nanoparticles have a large fraction of their
atoms on the surface making them highly reactive and their small size virtually
eliminates the solid-solid diffusion process as the rate limiting step. Materials that
normally require high temperatures and long annealing times become more accessible at
relatively low-temperatures because of the increased interfacial contact between the
nanoparticle reactants.
Metal nanoparticles, formed via reduction of metal salts in an aqueous solution
and stabilized by PVP (polyvinylpyrrolidone), were mixed into nanoparticle composites
in stoichometric proportions. The composite mixtures were then annealed at relatively
low temperatures to form alloy and intermetallic compounds at or below 600 degrees C. This
method was further extended to synthesizing multi-metal oxide systems by annealing metal oxide nanoparticle composites hundreds of degrees lower than more traditional
methods.
Nanoparticles of Pt (supported or unsupported) were added to a metal salt
solution of tetraethylene glycol and heated to obtain alloy and intermetallic
nanoparticles. The supported intermetallic nanoparticles were tested as catalysts and
PtPb/Vulcan XC-72 showed enhanced catalytic activity for formic acid oxidation while
Pt3Sn/Vulcan XC-72 and Cu3Pt/y-Al2O3 catalyzed CO oxidiation at lower temperatures
than supported Pt.
Intermetallic nanoparticles of Pd were synthesized by conversion chemistry
methods previously mentioned and were supported on carbon and alumina. These
nanoparticles were tested for
Suzuki cross-coupling reactions. However; the
homocoupled product was generally favored. The catalytic activity of Pd3Pb/y-Al2O3
was tested for the Heck
reaction and gave results comparable to Pd/y-Al2O3 with a
slightly better selectivity.
Conversion chemistry techniques were used to convert Pt nanocubes into Ptbased
intermetallic nanocrystals in solution. It was discovered that aggregated clusters
of Pt nanoparticles were capable of converting to FePt3; however, when Pt nanocubes
were used the intermetallic phase did not form. Alternatively, it was possible to form
PtSn nanocubes by a conversion
reaction with SnCl2.
Advisors/Committee Members: Schaak, Raymond E. (advisor), Clearfield, Abraham (advisor), Darensbourg, Marcetta (committee member), Ross, Joseph (committee member).
Subjects/Keywords: Nanoparticles; Catalysts; Alloys; Intermetallic Compounds; Multi-Metal Oxides; Fuel Cells; Formic Acid Oxidation; Methanol Oxidation; CO Oxidation; Suzuki Coupling Reaction; Heck Reaction; Nanocubes; Supported Nanoparticles; FePt3; Pt3Sn; PtPb; Nanocubes
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bauer, J. C. (2010). Nanoparticles as Reactive Precursors: Synthesis of Alloys, Intermetallic Compounds, and Multi-Metal Oxides Through Low-Temperature Annealing and Conversion Chemistry. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-642
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bauer, John C. “Nanoparticles as Reactive Precursors: Synthesis of Alloys, Intermetallic Compounds, and Multi-Metal Oxides Through Low-Temperature Annealing and Conversion Chemistry.” 2010. Thesis, Texas A&M University. Accessed October 16, 2019.
http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-642.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bauer, John C. “Nanoparticles as Reactive Precursors: Synthesis of Alloys, Intermetallic Compounds, and Multi-Metal Oxides Through Low-Temperature Annealing and Conversion Chemistry.” 2010. Web. 16 Oct 2019.
Vancouver:
Bauer JC. Nanoparticles as Reactive Precursors: Synthesis of Alloys, Intermetallic Compounds, and Multi-Metal Oxides Through Low-Temperature Annealing and Conversion Chemistry. [Internet] [Thesis]. Texas A&M University; 2010. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-642.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bauer JC. Nanoparticles as Reactive Precursors: Synthesis of Alloys, Intermetallic Compounds, and Multi-Metal Oxides Through Low-Temperature Annealing and Conversion Chemistry. [Thesis]. Texas A&M University; 2010. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-642
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
28.
Tenchiu, Alia - Cristina.
Σύνθεση β-D-γλυκοπυρανοζυλο-θειο-ημικαρβαζονών και συμπλόκων τους με μέταλλα μεταπτώσεως: εφαρμογές ως αναστολείς της φωσφορυλάσης του γλυκογόνου και ως καταλύτες σε αντιδράσεις σύζευξης.
Degree: 2012, University of Ioannina; Πανεπιστήμιο Ιωαννίνων
URL: http://hdl.handle.net/10442/hedi/33254
► A series of twenty six aromatic aldehyde/ketone 4-(β-D-glucopyranosyl)thiosemicarbazones (βGluTSC) have been synthesized. The thiosemicarbazone part of the studied glucosyl thiosemicarbazones possess a moiety derived from…
(more)
▼ A series of twenty six aromatic aldehyde/ketone 4-(β-D-glucopyranosyl)thiosemicarbazones (βGluTSC) have been synthesized. The thiosemicarbazone part of the studied glucosyl thiosemicarbazones possess a moiety derived from substituted benzaldehydes with NO2, F, Cl, Br, OH, OMe, CF3, tBu or Me at the ortho-, meta- or para-position of the aromatic ring as well as a moiety derived from 2-, 3- or 4-pyridinecarboxaldehyde, 1-ferrocenecarboxaldehyde, β-naphthalenecarboxaldehyde, 4-methoxy-acetophenone or 2-acetonaphthanone. The compounds were fully characterized by spectroscopic techniques, elemental analysis, and for two derivatives by X-ray analysis. The data indicate the β configuration, and the E configuration pertaining to the stereochemistry of the C=N bond. However, a partial conversion of the E into the Z form is possible in solution after several hours.Since glycogen phosphorylase (GP) is a promising target for the treatment of type 2 diabetes, in the process of structure based drug design for GP, fifteen of the above-mentioned aromatic aldehyde 4-(β-D-glucopyranosyl)thiosemicarbazones were evaluated as inhibitors of rabbit muscle glycogen phosphorylase b (GPb) by kinetic studies. These compounds are competitive inhibitors of GPb with respect to α-D-glucose-1-phosphate with IC50 values ranging from 5.7 to 524.3 μM. In order to elucidate the structural basis of their inhibition, the crystal structures of these compounds in complex with GPb at 1.95-2.23 Å resolution were determined. The complex structures reveal that the inhibitors are accommodated at the catalytic site with the glucopyranosyl moiety at approximately the same position as α-D-glucose and stabilize the T conformation of the 280s loop. The molecules fit tightly into the β-pocket, a side channel from the catalytic site with no access to the bulk solvent. The differences in their inhibitory potency can be interpreted in terms of variations in the interactions of the aldehyde-derived moiety with protein residues in the β-pocket. In addition, fourteen out of the fifteen studied inhibitors were found bound at the new allosteric site of the enzyme.Mononuclear Ni(II) (diamagnetic as well as paramagnetic), Pd(II) and Pt(II) complexes with βGluTSC derivatives have also been prepared. The structures features of the complexes have been characterized by NMR, FT-IR and mass spectroscopy. A palladium(II) complex was found to be an efficient catalyst for the Suzuki and Heck reactions even in air atmosphere.
Συντέθηκαν 26 αρωματικές αλδεΰδες/κετόνες 4-(β-D-γλυκοπυρανοζυλο)θειοημικαρβαζόνες (βGluTSC). Το τμήμα της θειοημικαρβαζόνης των προς μελέτη παραγώγων προέρχεται από υποκατεστημένες βενζαλδεΰδες με NO2, F, Cl, Br, OH, OMe, CF3, tBu ή Me στην ορθο-, μετα- ή παρα-θέση του αρωματικού δακτυλίου καθώς επίσης και από 2-, 3- ή 4-πυριδινο-καρβοξαλδεΰδη, 1-φερροκενο-καρβοξαλδεΰδη, β-ναφθαλενο-καρβοξαλδεΰδη, 4-μεθοξυ-ακετοφαινόνη ή 2-ακετοναφθόνη. Οι ενώσεις χαρακτηρίσθηκαν πλήρως με φασματοσκοπικές τεχνικές, στοιχειακές αναλύσεις και για δύο από αυτές με ανάλυση ακτίνων…
Subjects/Keywords: Υδατάνθρακες; Θειοημικαρβαζόνες; Γλυκοπυρανοζυλο-θειοημικαρβαζόνες; Κρυσταλλική δομή; Διαβήτης τύπου 2; Αναστολείς της φωσφορυλάσης του γλυκογόνου; Σύμπλοκα μετάλλων μετάπτωσης; Αντίδραση Heck; Αντίδραση Suzuki; Carbohydrates; Thiosemicarbazones; Glucopyranosyl-thiosemicarbazones; Crystal structure; Diabetes type 2; Glycogen phosphorylase inhibitors; Transitional metal complexes; Heck reaction; Suzuki reaction
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tenchiu, A. -. C. (2012). Σύνθεση β-D-γλυκοπυρανοζυλο-θειο-ημικαρβαζονών και συμπλόκων τους με μέταλλα μεταπτώσεως: εφαρμογές ως αναστολείς της φωσφορυλάσης του γλυκογόνου και ως καταλύτες σε αντιδράσεις σύζευξης. (Thesis). University of Ioannina; Πανεπιστήμιο Ιωαννίνων. Retrieved from http://hdl.handle.net/10442/hedi/33254
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tenchiu, Alia - Cristina. “Σύνθεση β-D-γλυκοπυρανοζυλο-θειο-ημικαρβαζονών και συμπλόκων τους με μέταλλα μεταπτώσεως: εφαρμογές ως αναστολείς της φωσφορυλάσης του γλυκογόνου και ως καταλύτες σε αντιδράσεις σύζευξης.” 2012. Thesis, University of Ioannina; Πανεπιστήμιο Ιωαννίνων. Accessed October 16, 2019.
http://hdl.handle.net/10442/hedi/33254.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tenchiu, Alia - Cristina. “Σύνθεση β-D-γλυκοπυρανοζυλο-θειο-ημικαρβαζονών και συμπλόκων τους με μέταλλα μεταπτώσεως: εφαρμογές ως αναστολείς της φωσφορυλάσης του γλυκογόνου και ως καταλύτες σε αντιδράσεις σύζευξης.” 2012. Web. 16 Oct 2019.
Vancouver:
Tenchiu A-C. Σύνθεση β-D-γλυκοπυρανοζυλο-θειο-ημικαρβαζονών και συμπλόκων τους με μέταλλα μεταπτώσεως: εφαρμογές ως αναστολείς της φωσφορυλάσης του γλυκογόνου και ως καταλύτες σε αντιδράσεις σύζευξης. [Internet] [Thesis]. University of Ioannina; Πανεπιστήμιο Ιωαννίνων; 2012. [cited 2019 Oct 16].
Available from: http://hdl.handle.net/10442/hedi/33254.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tenchiu A-C. Σύνθεση β-D-γλυκοπυρανοζυλο-θειο-ημικαρβαζονών και συμπλόκων τους με μέταλλα μεταπτώσεως: εφαρμογές ως αναστολείς της φωσφορυλάσης του γλυκογόνου και ως καταλύτες σε αντιδράσεις σύζευξης. [Thesis]. University of Ioannina; Πανεπιστήμιο Ιωαννίνων; 2012. Available from: http://hdl.handle.net/10442/hedi/33254
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
29.
Allouch, Fatima.
Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes.
Degree: Docteur es, Chimie, 2013, Dijon; Université libanaise
URL: http://www.theses.fr/2013DIJOS002
► Ce mémoire porte sur l’accès simple et peu coûteux à de nouveaux ligands ferrocéniques aminés et aminophosphinés et leur coordination avec des métaux de transition…
(more)
▼ Ce mémoire porte sur l’accès simple et peu coûteux à de nouveaux ligands ferrocéniques aminés et aminophosphinés et leur coordination avec des métaux de transition pour des applications en catalyse homogène.Des métallo-ligands aminés flexibles ont été obtenus et caractérisés après amination réductrice du 1,1’-diformylferrocène. D’autres ligands (N,N) rigides ont été isolés au départ du précurseur du 1,1’-di-tert-butyl-3,3’-diformylferrocène. Des aza-ferrocénophanes ont également été facilement préparés avec ces deux précurseurs carbonylés. Lors de la coordination de ces ligands avec le palladium, un palladacycle original a été isolé et caractérisé par diffraction de rayons X.Des ligands ferrocéniques (N,P) ont été obtenus par trois méthodes: i) ortholithiation de ligands ferrocéniques aminés suivie d’un ajout de chlorophosphine, ii) amination réductrice des ferrocènes formylés substitués ou non en présence d’amine portant une fonction phosphine, iii) substitution directe du ferrocène dilithié par des chlorophosphines comportant un hétérocycle azoté. Leur coordination avec du palladium et du platine a été étudiée. Ces métallo-ligands hybrides ont été impliqués dans des réactions de chlorures d’aryle avec des acides arylboroniques (couplage de Suzuki), ainsi que dans la réaction de Sonogashira avec le couplage de bromures et de chlorures d’aryle avec le phénylacétylène
This thesis focuses on simple and inexpensive access to new amino and aminophosphine ferrocenyl ligands and their coordination with transition metals for applications in homogeneous catalysis.Flexible amine metallo-ligands were obtained and characterized after reductive amination of 1,1'-diformylferrocene. Other rigid (N,N) ligands were isolated starting from the precursor 1,1'-di-tert-butyl-3, 3'-diformylferrocene. Aza-ferrocenophanes were also easily prepared with these two formyl precursors. During the coordination of these ligands with palladium, a stable and original palladacycle was isolated and characterized by DRX.(N,P) ferrocenyl ligands were obtained by three methods: i) ortholithiation of aminoferrocenyl ligands followed by addition of chlorophosphines, ii) reductive amination of substituted or not formylferrocene in the presence of amine bearing a phosphine function, iii) direct substitution of dilithiated ferrocene by chlorophosphines with a nitrogen-containing heterocycle. Their coordination with palladium and platinum has been studied. These hybrid metallo-ligands have been implicated in the reactions of aryl chlorides to arylboronic acids (Suzuki cross-coupling), as well as in the Sonogashira reaction involving of coupling aryl bromides and chlorides to phenylacetylene
Advisors/Committee Members: Pirio, Nadine (thesis director), Naoufal, Daoud (thesis director).
Subjects/Keywords: Métallo-ligands ferrocéniques aminés et aminophosphinés; Palladation; Amination réductrice; Ligands hybrides (N,P); Réaction de couplage carbone-carbone; Suzuki; Sonogashira; Amino and aminophosphine ferrocenyl metallo-ligand; Palladation; Reductive amination; N,P hybrid ligands; C-C cross-coupling reaction; Suzuki; Sonogashira; 541.2; 541.39; 547
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Allouch, F. (2013). Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes. (Doctoral Dissertation). Dijon; Université libanaise. Retrieved from http://www.theses.fr/2013DIJOS002
Chicago Manual of Style (16th Edition):
Allouch, Fatima. “Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes.” 2013. Doctoral Dissertation, Dijon; Université libanaise. Accessed October 16, 2019.
http://www.theses.fr/2013DIJOS002.
MLA Handbook (7th Edition):
Allouch, Fatima. “Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes.” 2013. Web. 16 Oct 2019.
Vancouver:
Allouch F. Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes. [Internet] [Doctoral dissertation]. Dijon; Université libanaise; 2013. [cited 2019 Oct 16].
Available from: http://www.theses.fr/2013DIJOS002.
Council of Science Editors:
Allouch F. Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes. [Doctoral Dissertation]. Dijon; Université libanaise; 2013. Available from: http://www.theses.fr/2013DIJOS002
Universidade do Estado do Rio de Janeiro
30.
Pâmella Santos de Souza.
Estudo da reação de modificação do poli(cloreto de vinila) com nucleófilos nitrogenados e das aplicações como suporte em reações de acoplamento.
Degree: Master, 2015, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8526
;
► Neste trabalho foi realizada a modificação química do poli(cloreto de vinila) (PVC) pela sua reação com azida de sódio, onde alguns dos seus átomos de…
(more)
▼ Neste trabalho foi realizada a modificação química do poli(cloreto de vinila) (PVC) pela sua reação com azida de sódio, onde alguns dos seus átomos de cloro foram substituídos por azidas. Em seguida o grupo incorporado foi transformado em triazóis por uma reação de cicloadição 1,3 entre o polímero modificado e propiolato de etila, sendo a reação catalisada por iodeto de cobre. Essas reações foram conduzidas sob aquecimento convencional e empregando irradiação de micro-ondas. Inicialmente, a reação incorporou 20% de triazol no PVC, sendo avaliadas as condições reacionais ideais. Essas condições foram usadas para a formação de novos copolímeros com diferentes teores de triazóis incorporados. Os produtos obtidos foram usados para o suporte de paládio que é utilizado como catalisador na reação de Suzuki-Miyaura. Todos os copolímeros foram caracterizados por espectroscopia na região do infravermelho com transformada de Fourier (FTIR)
In this work was performed the chemical modification of poly(vinyl chloride) (PVC) by its reaction with sodium azide, in which some of their chlorine atoms has been replaced with azides. Then the azide group was converted to 1,2,3-triazoles by a 1,3-cycloaddition reaction between the modified polymer and ethyl propiolate, the reaction was catalyzed by copper iodide. These reactions were conducted using conventional heating and microwave irradiation. Initially, the reaction incorporated triazole in 20% of PVC, the optimal reaction conditions was evaluated. These conditions were used for the formation of new copolymers with different amounts of incorporated triazoles. The products obtained were used as a support for palladium, which is used as a catalyst in Suzuki-Miyaura reaction. All copolymers were characterized by infrared spectroscopy, Fourier transform spectroscopy (FTIR)
Advisors/Committee Members: Pedro Ivo Canesso Guimarães, Ayres Guimarães Dias, Raquel Ana Capela Leão, Jorge Luiz de Oliveira Domingos.
Subjects/Keywords: Poli(cloreto de vinila) modificado; nitrila; azida; triazóis; click chemistry; micro-ondas; reação de Suzuki-Miyaura; paládio acoplado; Poly(vinyl chloride) modified; nitrile; azide; triazoles; click Chemistry; microwave; Suzuki-Miyaura reaction; coupled palladium; POLIMEROS E COLOIDES
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Souza, P. S. d. (2015). Estudo da reação de modificação do poli(cloreto de vinila) com nucleófilos nitrogenados e das aplicações como suporte em reações de acoplamento. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8526 ;
Chicago Manual of Style (16th Edition):
Souza, Pâmella Santos de. “Estudo da reação de modificação do poli(cloreto de vinila) com nucleófilos nitrogenados e das aplicações como suporte em reações de acoplamento.” 2015. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed October 16, 2019.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8526 ;.
MLA Handbook (7th Edition):
Souza, Pâmella Santos de. “Estudo da reação de modificação do poli(cloreto de vinila) com nucleófilos nitrogenados e das aplicações como suporte em reações de acoplamento.” 2015. Web. 16 Oct 2019.
Vancouver:
Souza PSd. Estudo da reação de modificação do poli(cloreto de vinila) com nucleófilos nitrogenados e das aplicações como suporte em reações de acoplamento. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2015. [cited 2019 Oct 16].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8526 ;.
Council of Science Editors:
Souza PSd. Estudo da reação de modificação do poli(cloreto de vinila) com nucleófilos nitrogenados e das aplicações como suporte em reações de acoplamento. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2015. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8526 ;
◁ [1] [2] ▶
. 
Open Access Theses and Dissertations