subject:(Surgical PET Imaging Probe System)

1. Huh, Sam Seoung. Preliminary Study of an Intra-operative PET Imaging Probe System.

Degree: PhD, Biomedical Engineering, 2011, University of Michigan

URL: http://hdl.handle.net/2027.42/86331

► PET imaging has gained widespread acceptance in cancer imaging because Positron Emission Tomography can identify physiological changes due to cancer. Nevertheless conventional PET imaging has… (more)

Subjects/Keywords: Realtime Intraopeative PET Imaging; Online Parallel Image Reconstruction; Modified One Pass MLEM; Surgical PET Imaging Probe System; Image Guided Surgery; Biomedical Engineering; Engineering

…140 CHAPTER 5 PROTOTYPE OF THE PET IMAGING PROBE SYSTEM ........... 141 5 .1 A PIXILATED… …246 6. 2 .1 Interpretation of the PET Imaging Probe System: Adaptive Imaging System… …248 6. 2 .6 A Second-Generation Prototype of the PET Imaging Probe System ......... 248… …29 FIGURE 2-4. ILLUSTRATION OF THE INTRA-OPERATIVE PET IMAGING PROBE SYSTEM. ...... 31… …32 FIGURE 2-6. INTRA-OPERATIVE PET IMAGING PROBE SYSTEM WITH ZUBAL PHANTOM. THE IMAGING…

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APA (6^th Edition):

Huh, S. S. (2011). Preliminary Study of an Intra-operative PET Imaging Probe System. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/86331

Chicago Manual of Style (16^th Edition):

Huh, Sam Seoung. “Preliminary Study of an Intra-operative PET Imaging Probe System.” 2011. Doctoral Dissertation, University of Michigan. Accessed January 19, 2021. http://hdl.handle.net/2027.42/86331.

MLA Handbook (7^th Edition):

Huh, Sam Seoung. “Preliminary Study of an Intra-operative PET Imaging Probe System.” 2011. Web. 19 Jan 2021.

Vancouver:

Huh SS. Preliminary Study of an Intra-operative PET Imaging Probe System. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2027.42/86331.

Council of Science Editors:

Huh SS. Preliminary Study of an Intra-operative PET Imaging Probe System. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/86331

University of South Florida

2. Zhou, Fenger. Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes.

Degree: 2014, University of South Florida

URL: https://scholarcommons.usf.edu/etd/5339

► ABSTRACT Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor, which plays a pivotal part in the development of the central nervous system. Aberrant expression… (more)

Subjects/Keywords: Fluorine Capture; Kinase Inhibitor; PET imaging; PET Probe; Triazines; Chemistry; Organic Chemistry

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APA (6^th Edition):

Zhou, F. (2014). Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/5339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Fenger. “Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes.” 2014. Thesis, University of South Florida. Accessed January 19, 2021. https://scholarcommons.usf.edu/etd/5339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Fenger. “Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes.” 2014. Web. 19 Jan 2021.

Vancouver:

Zhou F. Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes. [Internet] [Thesis]. University of South Florida; 2014. [cited 2021 Jan 19]. Available from: https://scholarcommons.usf.edu/etd/5339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou F. Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes. [Thesis]. University of South Florida; 2014. Available from: https://scholarcommons.usf.edu/etd/5339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Medical Center

3. Tsao, Ning. Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.

Degree: PhD, 2013, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350

► The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents,… (more)

Subjects/Keywords: glycopeptide; Imaging probe; PET imaging; SPECT imaging; guanine; theranostics; drug delivery system; Amino Acids, Peptides, and Proteins; Diagnosis; Heterocyclic Compounds; Medicinal Chemistry and Pharmaceutics; Medicine and Health Sciences; Nucleic Acids, Nucleotides, and Nucleosides; Other Analytical, Diagnostic and Therapeutic Techniques and Equipment; Pharmacology; Radiology

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APA (6^th Edition):

Tsao, N. (2013). Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350

Chicago Manual of Style (16^th Edition):

Tsao, Ning. “Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.” 2013. Doctoral Dissertation, Texas Medical Center. Accessed January 19, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350.

MLA Handbook (7^th Edition):

Tsao, Ning. “Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.” 2013. Web. 19 Jan 2021.

Vancouver:

Tsao N. Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery. [Internet] [Doctoral dissertation]. Texas Medical Center; 2013. [cited 2021 Jan 19]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350.

Council of Science Editors:

Tsao N. Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery. [Doctoral Dissertation]. Texas Medical Center; 2013. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350

University of California – San Francisco

4. Kwak, Tiffany. Evaluation of D-Amino Acids as Probes for Molecular Imaging of Bacterial Infections.

Degree: Biomedical Imaging, 2015, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/12z10686

► Purpose: The goal of this study was to investigate a panel of D-amino acids and select potential probe candidates for imaging bacterial infections in vivo.Methods:… (more)

Subjects/Keywords: Medical imaging; Biomedical engineering; Microbiology; Bacterial Infection; D-Amino Acid; Molecular Imaging; Nuclear Chemistry; PET; Radiolabeled Probe

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APA (6^th Edition):

Kwak, T. (2015). Evaluation of D-Amino Acids as Probes for Molecular Imaging of Bacterial Infections. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/12z10686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kwak, Tiffany. “Evaluation of D-Amino Acids as Probes for Molecular Imaging of Bacterial Infections.” 2015. Thesis, University of California – San Francisco. Accessed January 19, 2021. http://www.escholarship.org/uc/item/12z10686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kwak, Tiffany. “Evaluation of D-Amino Acids as Probes for Molecular Imaging of Bacterial Infections.” 2015. Web. 19 Jan 2021.

Vancouver:

Kwak T. Evaluation of D-Amino Acids as Probes for Molecular Imaging of Bacterial Infections. [Internet] [Thesis]. University of California – San Francisco; 2015. [cited 2021 Jan 19]. Available from: http://www.escholarship.org/uc/item/12z10686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kwak T. Evaluation of D-Amino Acids as Probes for Molecular Imaging of Bacterial Infections. [Thesis]. University of California – San Francisco; 2015. Available from: http://www.escholarship.org/uc/item/12z10686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Levigoureux, Elise. Vers l'imagerie in vivo de l'alpha-synucléine. : Toward in vivo imaging of alpha-synuclein.

Degree: Docteur es, Neurosciences, 2015, Université Claude Bernard – Lyon I

URL: http://www.theses.fr/2015LYO10313

►

Les maladies neurodégénératives sont un sujet de santé publique majeur. La maladie de Parkinson (MP), la démence à corps de Lewy (DCL) et l'atrophie multisystématisée… (more)

▼

Les maladies neurodégénératives sont un sujet de santé publique majeur. La maladie de Parkinson (MP), la démence à corps de Lewy (DCL) et l'atrophie multisystématisée (AMS) font partie d'une famille liées à l'accumulation pathologique d'une protéine : l'α-synucléine (α-syn), appelées les synucléinopathies. Il n'existe pas méthode de diagnostic formel pre-mortem de ces pathologies. À ce jour, la confirmation définitive de synucléinopathies n'est possible que sur des études post-mortem. Le mécanisme de survenue reste incompris. L'exploration des systèmes de neurotransmission et des voies métaboliques pourrait permettre d'élucider ces mécanismes. Les travaux effectués au cours de cette thèse se positionnent dans une optique de développement d'un outil de diagnostic précoce et de compréhension des mécanismes physiopathologiques grâce à l'imagerie TEP. Dans une première partie, nous avons caractérisé et validé un modèle murin de synucléinopathies. Nous avons conclu que le [18F]BF227 ne pouvait être employé comme radiotraceur des agrégats d'α-syn. La seconde partie a permis la mise au point d'une technique d'évaluation de l'affinité de molécules pour une cible donnée. Douze ligands froids ont pu être testés in vitro. Actuellement, aucun composé ne semble présenter les critères pour être un radiotraceur idéal. Enfin, la dernière partie a mis en évidence un hypométabolisme glucidique ainsi qu'une surexpression des récepteurs 5-HT1A à un stade précoce de la pathologie. Au final, cette étude a montré l'intérêt et les limites de l'imagerie TEP et des modèles animaux pour le développement d'un nouveau radiotraceur ainsi que pour l'exploration des mécanismes physiopathologiques

Neurodegenerative diseases are a major public health issue. Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are part of a family related to the pathological accumulation of a protein, α-synuclein (α- syn), and called synucleinopathies. To date, there is no pre-mortem formal diagnosis method for these diseases and the final confirmation only relies on postmortem studies. While the occurrence mechanisms remain unclear, exploration of neurotransmitter systems and metabolic pathways could bring more information on the underlying pathophysiological processes. The aims of this PhD work were (1) to develop the first radioligand targeting α-syn as an early diagnostic tool and (2) to investigate, with PET imaging, how neurotransmitter systems relates to pathophysiological mechanisms in an accelerated mouse model of synucleinopathy. In the first part of this study, we demonstrated the inability of in vivo PET imaging with [18F]BF227 to label α-syn aggregates in a model of synucleinopathy. The second part allowed the development of a competitive radioligand binding assay to determine α-syn binding parameters of non-radioactive candidate molecules. Twelve ligands were tested in vitro. Currently, no compound appears to present ideal α-syn binding properties. The last part of this study highlighted a serotoninergic…

Advisors/Committee Members: Zimmer, Luc (thesis director), Lancelot, Sophie (thesis director).

Subjects/Keywords: Imagerie TEP; Synucléinopathies; Modèle animal; Système sérotoninergique; PET imaging; Synucleinopathies; Animal model; Serotonin system; 612.8

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APA (6^th Edition):

Levigoureux, E. (2015). Vers l'imagerie in vivo de l'alpha-synucléine. : Toward in vivo imaging of alpha-synuclein. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2015LYO10313

Chicago Manual of Style (16^th Edition):

Levigoureux, Elise. “Vers l'imagerie in vivo de l'alpha-synucléine. : Toward in vivo imaging of alpha-synuclein.” 2015. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed January 19, 2021. http://www.theses.fr/2015LYO10313.

MLA Handbook (7^th Edition):

Levigoureux, Elise. “Vers l'imagerie in vivo de l'alpha-synucléine. : Toward in vivo imaging of alpha-synuclein.” 2015. Web. 19 Jan 2021.

Vancouver:

Levigoureux E. Vers l'imagerie in vivo de l'alpha-synucléine. : Toward in vivo imaging of alpha-synuclein. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2015. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2015LYO10313.

Council of Science Editors:

Levigoureux E. Vers l'imagerie in vivo de l'alpha-synucléine. : Toward in vivo imaging of alpha-synuclein. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2015. Available from: http://www.theses.fr/2015LYO10313

University of Toronto

6. Gaudette, Erin Victoria. Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB.

Degree: 2020, University of Toronto

URL: http://hdl.handle.net/1807/103310

►

Background: Preclinical studies suggest that levels of Fatty Acid Amide Hydrolase (FAAH)—the catabolic enzyme for the endocannabinoid anandamide—may be elevated in the amygdala in posttraumatic… (more)

Subjects/Keywords: Endocannabinoid System; Fatty Acid Amide Hydrolase; Neuroimaging; PET imaging; Posttraumatic Stress Disorder; 0317

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APA (6^th Edition):

Gaudette, E. V. (2020). Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/103310

Chicago Manual of Style (16^th Edition):

Gaudette, Erin Victoria. “Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB.” 2020. Masters Thesis, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/103310.

MLA Handbook (7^th Edition):

Gaudette, Erin Victoria. “Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB.” 2020. Web. 19 Jan 2021.

Vancouver:

Gaudette EV. Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB. [Internet] [Masters thesis]. University of Toronto; 2020. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/103310.

Council of Science Editors:

Gaudette EV. Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB. [Masters Thesis]. University of Toronto; 2020. Available from: http://hdl.handle.net/1807/103310

Northeastern University

7. Hargrove, Katherine. Synthesis of PET imaging agents and analogues thereof utilizing microwave and microfluidic technology.

Degree: MS, Department of Chemistry and Chemical Biology, 2016, Northeastern University

URL: http://hdl.handle.net/2047/D20199837

► In recent years, ¹⁸F labeled ligands have played a key role in positron emission tomography (PET) imaging. Due to the short half-life of these radiolabeled… (more)

Subjects/Keywords: microwave; PET imaging; Tomography, Emission; Central nervous system; Imaging; Blood-brain barrier; Palladium catalysts; Microfluidics; Microwaves

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APA (6^th Edition):

Hargrove, K. (2016). Synthesis of PET imaging agents and analogues thereof utilizing microwave and microfluidic technology. (Masters Thesis). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20199837

Chicago Manual of Style (16^th Edition):

Hargrove, Katherine. “Synthesis of PET imaging agents and analogues thereof utilizing microwave and microfluidic technology.” 2016. Masters Thesis, Northeastern University. Accessed January 19, 2021. http://hdl.handle.net/2047/D20199837.

MLA Handbook (7^th Edition):

Hargrove, Katherine. “Synthesis of PET imaging agents and analogues thereof utilizing microwave and microfluidic technology.” 2016. Web. 19 Jan 2021.

Vancouver:

Hargrove K. Synthesis of PET imaging agents and analogues thereof utilizing microwave and microfluidic technology. [Internet] [Masters thesis]. Northeastern University; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2047/D20199837.

Council of Science Editors:

Hargrove K. Synthesis of PET imaging agents and analogues thereof utilizing microwave and microfluidic technology. [Masters Thesis]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20199837

8. Ammour, Luis. Développement d'une sonde intracérébrale à pixels actifs pour l'imagerie bêta du cerveau du rat libre de ses mouvements : Development of an Intracerebral Probe with Active Pixels for Beta Imaging of the Freely-moving Rat Brain.

Degree: Docteur es, Imagerie médicale et radioactivité, 2018, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2018SACLS497

► Au cours des 20 dernières années, de nombreux modèles animaux ont émergé, permettant le développement de nouvelles approches pour l'étude préclinique du cerveau sain et… (more)

▼ Au cours des 20 dernières années, de nombreux modèles animaux ont émergé, permettant le développement de nouvelles approches pour l'étude préclinique du cerveau sain et pathologique. Les rongeurs sont ainsi devenus des acteurs incontournables des avancées thérapeutiques. Dans ce contexte, l'imagerie radioisotopique, qui permet de quantifier des traceurs radioactifs avec une sensibilité excellente, constitue un outil de choix l'étude des processus cérébraux in vivo. Mais, jusqu'à présent, les techniques de radioimagerie les plus courantes imposent l'anesthésie ou l'immobilisation de l'animal. Or, les anesthésiants affectent les processus biologiques étudiés. De plus, il existe un vif intérêt pour l'étude simultanée du comportement de l'animal. L'acquisition d'une image dynamique des processus cérébraux concomitante à la mesure du comportement de l'animal éveillé et libre de ses mouvements est une information précieuse pour l'étude de l'addiction, de la mémoire, etc.À IMNC, nous avons abordé la neuroimagerie comportementale par une approche originale basée sur des sondes intracérébrales qui mesurent la concentration du traceur radioactif par détection directe des positons in situ. La sonde PIXSIC, basée sur un capteur pixelisé à diodes de silicium, a démontré leur pertinence dans le cadre d'études pharmacologiques chez l'animal totalement libre de ses mouvements. Toutefois, PIXSIC a montré quelques limitations pour son utilisation longitudinale : un niveau de bruit élevé dû aux perturbations électromagnétiques, une forte sensibilité au rayonnement gamma d'annihilation et une grande fragilité mécanique de l'implant aminci à 200 micromètres. En nous appuyant sur l'avènement des technologies CMOS pour la détection des particules chargées en physique des hautes énergies, nous avons pour ambition de concevoir MAPSSIC, une sonde qui réponde aux difficultés mises en avant par PIXSIC. Les capteurs CMOS permettent d'inclure l'amplification au niveau des pixels, limitant ainsi le bruit d'origine électromagnétique. Le volume sensible peut être réduit à une épaisseur de quelques dizaines de micromètres, réduisant ainsi fortement la sensibilité aux gammas et autorisant l'augmentation de son épaisseur totale pour assurer sa robustesse mécanique. Enfin, les capteurs CMOS nous permettent de concevoir un détecteur fortement pixelisé pour accéder à de nouvelles capacités d'imagerie. Cette thèse a eu pour objectif de développer une version optimisé de la sonde. Pour cela, nous avons imaginé un premier prototype de capteur CMOS et nous avons développé un modèle Monte Carlo pour estimer ses propriétés de détection. Nous avons pu démontrer que ses performances le qualifiait pour l'usage prévu. Notamment en terme de sensibilité, de volume d’isoefficacité et d’énergie déposée. Nous avons également pu explorer plusieurs paramètres d’optimisation, les dimensions des pixels et l’épaisseur de la zone sensible, qui nous permettent de considérer MAPSSIC au delà du premier prototype. Fort de ces bases théoriques nous avons conçu plusieurs… Advisors/Committee Members: Laniece, Philippe (thesis director).

Subjects/Keywords: Études comportementales; Neuroimagerie préclinique; Instrumentation nucléaire; Sondes intracérébrales; Simulations Monte Carlo; Imagerie TEP; Intracerebral probe; Nuclear instrumentation; Behavioral studies; Preclinical neuroimaging; Monte Carlo simulations; PET imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ammour, L. (2018). Développement d'une sonde intracérébrale à pixels actifs pour l'imagerie bêta du cerveau du rat libre de ses mouvements : Development of an Intracerebral Probe with Active Pixels for Beta Imaging of the Freely-moving Rat Brain. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2018SACLS497

Chicago Manual of Style (16^th Edition):

Ammour, Luis. “Développement d'une sonde intracérébrale à pixels actifs pour l'imagerie bêta du cerveau du rat libre de ses mouvements : Development of an Intracerebral Probe with Active Pixels for Beta Imaging of the Freely-moving Rat Brain.” 2018. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 19, 2021. http://www.theses.fr/2018SACLS497.

MLA Handbook (7^th Edition):

Ammour, Luis. “Développement d'une sonde intracérébrale à pixels actifs pour l'imagerie bêta du cerveau du rat libre de ses mouvements : Development of an Intracerebral Probe with Active Pixels for Beta Imaging of the Freely-moving Rat Brain.” 2018. Web. 19 Jan 2021.

Vancouver:

Ammour L. Développement d'une sonde intracérébrale à pixels actifs pour l'imagerie bêta du cerveau du rat libre de ses mouvements : Development of an Intracerebral Probe with Active Pixels for Beta Imaging of the Freely-moving Rat Brain. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2018. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2018SACLS497.

Council of Science Editors:

Ammour L. Développement d'une sonde intracérébrale à pixels actifs pour l'imagerie bêta du cerveau du rat libre de ses mouvements : Development of an Intracerebral Probe with Active Pixels for Beta Imaging of the Freely-moving Rat Brain. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2018. Available from: http://www.theses.fr/2018SACLS497

Wayne State University

9. Mchugh, Christopher. Imaging Anti-Proliferative Compounds With Flt-Pet.

Degree: PhD, Cancer Biology, 2016, Wayne State University

URL: https://digitalcommons.wayne.edu/oa_dissertations/1561

► Imaging is critical in the detection and management of malignancies, and positron emission tomography (PET) is an imaging approach that provides information regarding cancer… (more)

▼ Imaging is critical in the detection and management of malignancies, and positron emission tomography (PET) is an imaging approach that provides information regarding cancer physiology through the tracking of molecular pathways and receptors. 3’-fluoro-3’-deoxythymidine (FLT) is a PET tracer designed to image cellular proliferation, which is a hallmark of cancer. FLT has been used to study the response of cancer to a variety of treatments such as chemotherapy, targeted agents, and radiation. Here we explored FLT retention as a biomarker to monitor the anti-proliferative effect of the synthetic glucocorticoid (GC) dexamethasone (Dex) on non-small cell lung cancer (NSCLC). The basis for this work was the recent finding that Dex can cause reversible cell cycle arrest in a subset of NSCLC cells leading to chemotherapy resistance. A similar phenomenon has been shown in several other solid tumor models treated with GCs. Through studies of cell line models, human xenografts, and NSCLC patients, we observed that although the susceptibility to Dex-mediated cell cycle arrest is variable between cancers, it could be detected using FLT-PET. We also examined the FLT ‘flare’ phenomenon, in which FLT uptake is transiently increased following treatment with drugs that reduce cellular thymidine synthesis. Two routinely used chemotherapeutic agents, pemetrexed and capecitabine, were found to produce marked increases in FLT accumulation, though the effect was variable in patients treated with capecitabine. The success of FLT led to the introduction of other thymidine analog PET tracers including 1-(2’-deoxy-2’-fluoro-β-D-arabinofuranosyl) thymidine (FMAU) and 1-(2’-deoxy-2’-fluoro-β-D-arabinofuranosyl) uracil (FAU). Uptake of FMAU has been shown to be related to mitochondrial mass and cellular stress, while FAU is a prodrug that requires activation by thymidylate synthase. Although capecitabine treatment produced a change from baseline in patients imaged with FLT, tracer retention was unchanged in patients imaged with FMAU and FAU, highlighting the differences in imaging properties between the tracers. In summary, FLT continues to show promise as a tool for the non-invasive monitoring of cellular proliferation, and may be a useful biomarker for the prediction of GC sensitivity in solid tumors. Advisors/Committee Members: Anthony F. Shields.

Subjects/Keywords: Cancer; FLT; Imaging; PET; Biology

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APA (6^th Edition):

Mchugh, C. (2016). Imaging Anti-Proliferative Compounds With Flt-Pet. (Doctoral Dissertation). Wayne State University. Retrieved from https://digitalcommons.wayne.edu/oa_dissertations/1561

Chicago Manual of Style (16^th Edition):

Mchugh, Christopher. “Imaging Anti-Proliferative Compounds With Flt-Pet.” 2016. Doctoral Dissertation, Wayne State University. Accessed January 19, 2021. https://digitalcommons.wayne.edu/oa_dissertations/1561.

MLA Handbook (7^th Edition):

Mchugh, Christopher. “Imaging Anti-Proliferative Compounds With Flt-Pet.” 2016. Web. 19 Jan 2021.

Vancouver:

Mchugh C. Imaging Anti-Proliferative Compounds With Flt-Pet. [Internet] [Doctoral dissertation]. Wayne State University; 2016. [cited 2021 Jan 19]. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1561.

Council of Science Editors:

Mchugh C. Imaging Anti-Proliferative Compounds With Flt-Pet. [Doctoral Dissertation]. Wayne State University; 2016. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1561

University of Manitoba

10. Shams, Ehsan. A slow control system with gain stabilization for a small animal MR-compatible PET insert.

Degree: Biomedical Engineering, 2014, University of Manitoba

URL: http://hdl.handle.net/1993/30140

► The Biomedical Imaging Lab at the University of Manitoba is building an MR compatible PET insert system. The detectors include SensL SPM ArraySB-4 SiPMs and… (more)

Subjects/Keywords: PET; medical imaging; nuclear medicine

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APA (6^th Edition):

Shams, E. (2014). A slow control system with gain stabilization for a small animal MR-compatible PET insert. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/30140

Chicago Manual of Style (16^th Edition):

Shams, Ehsan. “A slow control system with gain stabilization for a small animal MR-compatible PET insert.” 2014. Masters Thesis, University of Manitoba. Accessed January 19, 2021. http://hdl.handle.net/1993/30140.

MLA Handbook (7^th Edition):

Shams, Ehsan. “A slow control system with gain stabilization for a small animal MR-compatible PET insert.” 2014. Web. 19 Jan 2021.

Vancouver:

Shams E. A slow control system with gain stabilization for a small animal MR-compatible PET insert. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1993/30140.

Council of Science Editors:

Shams E. A slow control system with gain stabilization for a small animal MR-compatible PET insert. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/30140

University of Minnesota

11. Glumac, Paige M. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.

Degree: PhD, Pharmacology, 2019, University of Minnesota

URL: http://hdl.handle.net/11299/206273

► An increasing number of men are developing a lethal, non-androgen receptor (AR) driven form of prostate cancer (PCa) known as aggressive variant prostate cancer (AVPC).… (more)

Subjects/Keywords: CD133; PET imaging; Prostate Cancer

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APA (6^th Edition):

Glumac, P. M. (2019). Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/206273

Chicago Manual of Style (16^th Edition):

Glumac, Paige M. “Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.” 2019. Doctoral Dissertation, University of Minnesota. Accessed January 19, 2021. http://hdl.handle.net/11299/206273.

MLA Handbook (7^th Edition):

Glumac, Paige M. “Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.” 2019. Web. 19 Jan 2021.

Vancouver:

Glumac PM. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/11299/206273.

Council of Science Editors:

Glumac PM. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/206273

Boston University

12. Nguyen, Hoan. Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative.

Degree: MS, Bioimaging, 2014, Boston University

URL: http://hdl.handle.net/2144/14667

► Progression of Alzheimer's disease has been associated with the deposition of aggregated amyloid beta (Aβ) protein in the brain. Though first described in post-mortal tissue,… (more)

Subjects/Keywords: Medical imaging; Alzheimer; PET; Symmetry

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APA (6^th Edition):

Nguyen, H. (2014). Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14667

Chicago Manual of Style (16^th Edition):

Nguyen, Hoan. “Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative.” 2014. Masters Thesis, Boston University. Accessed January 19, 2021. http://hdl.handle.net/2144/14667.

MLA Handbook (7^th Edition):

Nguyen, Hoan. “Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative.” 2014. Web. 19 Jan 2021.

Vancouver:

Nguyen H. Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2144/14667.

Council of Science Editors:

Nguyen H. Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14667

13. Lau, Jonathan. Ultra-High Field Magnetic Resonance Imaging for Stereotactic Neurosurgery.

Degree: 2019, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6194

► Stereotactic neurosurgery is a subspecialty within neurosurgery concerned with accurate targeting of brain structures. Deep brain stimulation (DBS) is a specific type of stereotaxy in… (more)

▼ Stereotactic neurosurgery is a subspecialty within neurosurgery concerned with accurate targeting of brain structures. Deep brain stimulation (DBS) is a specific type of stereotaxy in which electrodes are implanted in deep brain structures. It has proven therapeutic efficacy in Parkinson’s disease and Essential Tremor, but with an expanding number of indications under evaluation including Alzheimer’s disease, depression, epilepsy, and obesity, many more Canadians with chronic health conditions may benefit. Accurate surgical targeting is crucial with millimeter deviations resulting in unwanted side effects including muscle contractions, or worse, vessel injury. Lack of adequate visualization of surgical targets with conventional lower field strengths (1.5/3 Tesla) has meant that standard-of-care surgical treatment has relied on indirect targeting using standardized landmarks to find a correspondence with a histological ``template'' of the brain. For this reason, these procedures routinely require awake testing and microelectrode recording, which increases operating room time, patient discomfort, and risk of complications. Advances in ultra-high field (>= 7 Tesla or 7T) imaging have important potential implications for targeting structures enabling better visualization as a result of its increased (sub-millimeter) spatial resolution, tissue contrast, and signal-to-noise ratio. The work in this thesis explores ways in which ultra-high field magnetic resonance imaging can be integrated into the practice of stereotactic neurosurgery. In Chapter 2, an ultra-high field MRI template is integrated into the surgical workflow to assist with planning for deep brain stimulation surgery cases. Chapter 3 describes a novel anatomical fiducial placement protocol that is developed, validated, and used prospectively to quantify the limits of template-assisted surgical planning. In Chapter 4, geometric distortions at 7T that may impede the ability to perform accurate surgical targeting are characterized in participant data, and generally noted to be away from areas of interest for stereotactic targeting. Finally, Chapter 5 discusses a number of important stereotactic targets that are directly visualized and described for the first time in vivo, paving the way for patient-specific surgical planning using ultra-high field MRI.

Subjects/Keywords: accuracy; deep brain stimulation; magnetic resonance imaging; neuromodulation; stereotactic neurosurgery; surgical planning; Computational Neuroscience; Nervous System; Nervous System Diseases; Surgery; Surgical Procedures, Operative; Systems Neuroscience

10 more images…

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APA (6^th Edition):

Lau, J. (2019). Ultra-High Field Magnetic Resonance Imaging for Stereotactic Neurosurgery. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6194

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lau, Jonathan. “Ultra-High Field Magnetic Resonance Imaging for Stereotactic Neurosurgery.” 2019. Thesis, University of Western Ontario. Accessed January 19, 2021. https://ir.lib.uwo.ca/etd/6194.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lau, Jonathan. “Ultra-High Field Magnetic Resonance Imaging for Stereotactic Neurosurgery.” 2019. Web. 19 Jan 2021.

Vancouver:

Lau J. Ultra-High Field Magnetic Resonance Imaging for Stereotactic Neurosurgery. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Jan 19]. Available from: https://ir.lib.uwo.ca/etd/6194.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lau J. Ultra-High Field Magnetic Resonance Imaging for Stereotactic Neurosurgery. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6194

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rice University

14. Ye, Fan. Implanted Nanophotonic Probes for Deep Imaging in Scattering Media.

Degree: MS, Engineering, 2018, Rice University

URL: http://hdl.handle.net/1911/105627

► Optical imaging techniques that measure changes in calcium or voltage provide a promising route toward to large-scale measurement of neural activity and high spatial resolution… (more)

▼ Optical imaging techniques that measure changes in calcium or voltage provide a promising route toward to large-scale measurement of neural activity and high spatial resolution to resolve individual neurons. However, acquiring images through significant depths of the brain is difficult since brain tissue is extremely heterogeneous, which results in strong scattering by the various tissue components and limited penetration depth as well as achievable imaging resolution. To overcome the effects of scattering, optical imaging measurement techniques have been proposed ranging from laser scanning microscopy of submicron structures to diffuse optical tomography of large volumes of tissue. Recent advances in imaging technology such as light-sheet microscopy have enabled high-speed, high-resolution, three-dimensional volumetric imaging of large volumes of neural tissue. However, the light sheet microscopy technique fails to be compatible with opaque or scattering samples and has a limitation of the sample size by the two compact orthogonal illumination and detection objectives. In this work, I will show an implantable light sheet photonic probe integrated with a microlens that can produce a thin layer of illumination. With this planar illumination, the probe can image more than 500 microns deep below the surface of a brain tissue phantom, which is confirmed experimentally. First, I will make an introduction of the current optical imaging techniques, such as epi-fluorescence microscopy, laser scanning confocal microscopy, two-photon microscopy and conventional light sheet microscopy. Also, I will discuss the limitations and drawbacks of each method. Second, I will present the design and principle of the integrated light sheet photonic probe with a microlens that can produce a thin layer of light illumination perpendicular to the device plane. In addition, I will show the structure of the photonic probe and components of the imaging setup. Also, I will numerically and experimentally illustrate the light sheet can be created by a microlens diffraction. Then I will show the imaging result of inserting the photonic probe inside the brain tissue phantom and compare it to the conventional wide field microscopy. Finally, I will make a summary of my work and then talk about the future work of my research. Advisors/Committee Members: ROBINSON , JACOB (advisor).

Subjects/Keywords: implantable probe; deep brain imaging

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APA (6^th Edition):

Ye, F. (2018). Implanted Nanophotonic Probes for Deep Imaging in Scattering Media. (Masters Thesis). Rice University. Retrieved from http://hdl.handle.net/1911/105627

Chicago Manual of Style (16^th Edition):

Ye, Fan. “Implanted Nanophotonic Probes for Deep Imaging in Scattering Media.” 2018. Masters Thesis, Rice University. Accessed January 19, 2021. http://hdl.handle.net/1911/105627.

MLA Handbook (7^th Edition):

Ye, Fan. “Implanted Nanophotonic Probes for Deep Imaging in Scattering Media.” 2018. Web. 19 Jan 2021.

Vancouver:

Ye F. Implanted Nanophotonic Probes for Deep Imaging in Scattering Media. [Internet] [Masters thesis]. Rice University; 2018. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1911/105627.

Council of Science Editors:

Ye F. Implanted Nanophotonic Probes for Deep Imaging in Scattering Media. [Masters Thesis]. Rice University; 2018. Available from: http://hdl.handle.net/1911/105627

University of Manchester

15. Armstrong, Ian. Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography.

Degree: 2017, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784

► Positron Emission Tomography (PET) plays an essential role in the management of patients with cancer. It is used to detect and characterise malignancy as well… (more)

▼ Positron Emission Tomography (PET) plays an essential role in the management of patients with cancer. It is used to detect and characterise malignancy as well as monitor response to therapy. PET is a quantitative imaging tool, producing images that quantify the uptake of a radiotracer that has been administered to the patient. The most common measure of uptake derived from the image is known as a Standardised Uptake Value (SUV). Data acquired on the scanner is processed to produce images that are reported by clinicians. This task is known as image reconstruction and uses computational algorithms to process the scan data. The last decade has seen substantial development of these algorithms, which have become commercially available: modelling of the scanner spatial resolution (resolution modelling) and time of flight (TOF). The Biograph mCT was the first scanner from Siemens Healthcare to feature these two algorithms and the scanner at Central Manchester University Hospitals was the first Biograph mCT to go live in the UK. This PhD project, sponsored by Siemens Healthcare, aims to evaluate the effect of these algorithms on SUV in routine oncology imaging through a combination of phantom and patient studies.Resolution modelling improved visualisation of small objects and resulted in significant increases of uptake measurements. This may pose a challenge to clinicians when interpreting established uptake metrics that are used as an indication of disease status. Resolution modelling reduced the variability of SUV. This improved precision is particularly beneficial when assessing SUV changes during therapy monitoring.TOF was shown to reduce image noise with a conservation of FDG uptake measurements, relative to non-TOF algorithms. As a result of this work, TOF has been used routinely since mid-2014 at the CMUH department. This has facilitated a reduction of patient and staff radiation dose and an increase of 100 scans performed each year in the department. Advisors/Committee Members: WILLIAMS, HEATHER HA, Williams, Heather, Matthews, Julian.

Subjects/Keywords: Oncology; Medical Imaging; Image Reconstruction; PET imaging

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APA (6^th Edition):

Armstrong, I. (2017). Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784

Chicago Manual of Style (16^th Edition):

Armstrong, Ian. “Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography.” 2017. Doctoral Dissertation, University of Manchester. Accessed January 19, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784.

MLA Handbook (7^th Edition):

Armstrong, Ian. “Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography.” 2017. Web. 19 Jan 2021.

Vancouver:

Armstrong I. Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Jan 19]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784.

Council of Science Editors:

Armstrong I. Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784

16. Τριπολίτης, Χριστόφορος. Συλλογή δεδομένων από πρότυπο σύστημα PET.

Degree: 2009, University of Patras

URL: http://nemertes.lis.upatras.gr/jspui/handle/10889/2538

►

Στην εποχή της Μοριακής Ιατρικής, η ιατρική πληροφορία θα πρέπει να σχετίζεται με την λειτουργία των ιστών και των κυττάρων σε μοριακό επίπεδο. Η ιατρική… (more)

▼

Στην εποχή της Μοριακής Ιατρικής, η ιατρική πληροφορία θα πρέπει να σχετίζεται με την λειτουργία των ιστών και των κυττάρων σε μοριακό επίπεδο. Η ιατρική διάγνωση καθώς και ο σχεδιασμός και η αποτελεσματικότητα της θεραπείας απαιτούν λεπτομερή πληροφόρηση σε θέματα που αφορούν τον μεταβολισμό, τους υποδοχείς, αλλά και την γονιδιακή έκφραση των ιστών. Η Τομογραφία Εκπομπής Ποζιτρονίων (ΡΕΤ), μέθοδος της Πυρηνικής Ιατρικής είναι ο κυριότερος επί του παρόντος εκπρόσωπος της Μοριακής Απεικόνισης, διαγιγνώσκει δηλαδή απεικονιστικά παθήσεις σε μοριακό επίπεδο με την βοήθεια ραδιοφαρμάκων. Τα τελευταία χρόνια υπάρχει όλο και μεγαλύτερο ενδιαφέρον για την ανάπτυξη συστημάτων Τομογραφίας Εκπομπής Ποζιτρονίων που αφορούν την απεικόνιση μικρών ζώων (animal PET). Τα συστήματα αυτά είναι σχεδιασμένα ώστε να κάνουν απεικόνιση ανατομικών δομών μικρότερων από αυτές του ανθρώπου. Τα οφέλη πολλά, τόσο στην αξιολόγηση νέων ραδιοφαρμάκων, όσο και στην βελτίωση των κλινικών PET μέσα από την μελέτη και την ανάπτυξη τέτοιων πρότυπων συστημάτων. Το αντικείμενο της διπλωματικής εργασίας αφορά την μελέτη σε βάθος και κατανόηση της λειτουργίας ενός πρότυπου συστήματος PET (Positron Emission Tomography). Σε πειραματικό επίπεδο θα γίνει εκμάθηση και λήψη δεδομένων μέσω των ηλεκτρονικών μονάδων NIM. Τα χαρακτηριστικά του συστήματος που χρησιμοποιείται στην παρούσα εργασία είναι μια μικρή PET κάμερα, που αποτελείται από δυο κεφαλές βασισμένες σε χωρικά ευαίσθητο φωτοπολλαπλασιαστή H8500 και διακριτοποιημένο κρύσταλλο LSO κυψελίδων 2x2mm2, πεδίου διαστάσεων 5x5cm2. Κάθε κεφαλή περιλαμβάνει ένα φωτοπολλαπλασιαστή, ένα κρύσταλλο και ηλεκτρονικά τα οποία είναι υπεύθυνα για την προ-ενίσχυση. Το σύστημα συλλογής δεδομένων θα γίνει μέσω των ηλεκτρονικών NIM (Nuclear Instrumentation Module) και θα συγκριθεί με εκείνο του small animal PET. Σκοπός μας είναι να χρησιμοποιήσουμε τις κατάλληλες μονάδες (ενισχυτές, διευκρινιστές, μονάδες σύμπτωσης και gate and delay generators), ώστε να καταγραφεί το είδος των μεταφερομένων σημάτων σε όλες τις επιμέρους μονάδες. Στη συνέχεια και ύστερα από επεξεργασία των δεδομένων στον υπολογιστή θα πραγματοποιηθεί απεικόνιση ομοιωμάτων ή μικρών ζώων. Η σύγκριση καθώς και η κατανόηση της λειτουργίας του τρόπου με τον οποίο γίνεται η σύμπτωση και η συλλογή των δεδομένων θα μας βοηθήσει μελλοντικά στην ανάπτυξη ενός νέου συστήματος PET με βέλτιστα επιθυμητά χαρακτηριστικά.

In this work dual head PET camera, suitable for high resolution small animal studies has been developed. The system has a field of view of 5x5cm and is based on 2 H8500 position sensitive photomultiplier tubes (PSPMTs), coupled to two LSO crystals with 2.5x2.5mm pixel size. Then an FPGA based data acquisition system and proper data reconstruction system collect events, sort coincidences and produce images. We develop a system that is responsible for the coincidence detection based on NIM electronics. Systems evaluation has been carried out using FDG. Point sources have been used for systems calibration. Capillaries with 1.1mm inner diameter were…

Advisors/Committee Members: Νικηφορίδης, Γεώργιος, Tripolitis, Christoforos, Νικηφορίδης, Γεώργιος, Λούντος, Γεώργιος, Καγκάδης, Γεώργιος.

Subjects/Keywords: Κάμερα PET μικρών ζώων; NIM ηλεκτρονικά; Τεχνική σύμπτωσης; Παράθυρο σύμπτωσης; Μοριακή απεικόνιση; 616.075 75; Small PET; Resolving time; Coincidence detection system; Coincidence window; Molecular imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Τριπολίτης, �. (2009). Συλλογή δεδομένων από πρότυπο σύστημα PET. (Masters Thesis). University of Patras. Retrieved from http://nemertes.lis.upatras.gr/jspui/handle/10889/2538

Chicago Manual of Style (16^th Edition):

Τριπολίτης, Χριστόφορος. “Συλλογή δεδομένων από πρότυπο σύστημα PET.” 2009. Masters Thesis, University of Patras. Accessed January 19, 2021. http://nemertes.lis.upatras.gr/jspui/handle/10889/2538.

MLA Handbook (7^th Edition):

Τριπολίτης, Χριστόφορος. “Συλλογή δεδομένων από πρότυπο σύστημα PET.” 2009. Web. 19 Jan 2021.

Vancouver:

Τριπολίτης �. Συλλογή δεδομένων από πρότυπο σύστημα PET. [Internet] [Masters thesis]. University of Patras; 2009. [cited 2021 Jan 19]. Available from: http://nemertes.lis.upatras.gr/jspui/handle/10889/2538.

Council of Science Editors:

Τριπολίτης �. Συλλογή δεδομένων από πρότυπο σύστημα PET. [Masters Thesis]. University of Patras; 2009. Available from: http://nemertes.lis.upatras.gr/jspui/handle/10889/2538

Harvard University

17. Lacy, Jessica. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.

Degree: Doctor of Medicine, 2014, Harvard University

URL: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616

► Poly(ADP-ribose)polymerase-1 and -2 (PARP1/2) are nuclear proteins involved in DNA repair. Tumors with defects in homologous recombination, including BRCA1- and BRCA2-deficient cancers, have been shown… (more)

Subjects/Keywords: PARP; BRCA; PET imaging; PET/CT imaging; fluorescence microscopy

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APA (6^th Edition):

Lacy, J. (2014). Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. (Doctoral Dissertation). Harvard University. Retrieved from http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616

Chicago Manual of Style (16^th Edition):

Lacy, Jessica. “Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.” 2014. Doctoral Dissertation, Harvard University. Accessed January 19, 2021. http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616.

MLA Handbook (7^th Edition):

Lacy, Jessica. “Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.” 2014. Web. 19 Jan 2021.

Vancouver:

Lacy J. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. [Internet] [Doctoral dissertation]. Harvard University; 2014. [cited 2021 Jan 19]. Available from: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616.

Council of Science Editors:

Lacy J. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. [Doctoral Dissertation]. Harvard University; 2014. Available from: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616

University of Ottawa

18. Antoun, Rawad. Characterization of [11C]Methyl-Losartan as a Novel Radiotracer for PET Imaging of the AT1 Receptor .

Degree: 2011, University of Ottawa

URL: http://hdl.handle.net/10393/19806

► The Angiotensin II Type 1 (AT1) receptor is the main receptor responsible for the effects of the renin-angiotensin system, and its expression pattern is altered… (more)

Subjects/Keywords: Renin-angiotensin System; Losartan; [11C]Methyl-Losartan; Renal PET Imaging; Angiotensin II Type 1 (AT1) Receptor

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APA (6^th Edition):

Antoun, R. (2011). Characterization of [11C]Methyl-Losartan as a Novel Radiotracer for PET Imaging of the AT1 Receptor . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/19806

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Antoun, Rawad. “Characterization of [11C]Methyl-Losartan as a Novel Radiotracer for PET Imaging of the AT1 Receptor .” 2011. Thesis, University of Ottawa. Accessed January 19, 2021. http://hdl.handle.net/10393/19806.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Antoun, Rawad. “Characterization of [11C]Methyl-Losartan as a Novel Radiotracer for PET Imaging of the AT1 Receptor .” 2011. Web. 19 Jan 2021.

Vancouver:

Antoun R. Characterization of [11C]Methyl-Losartan as a Novel Radiotracer for PET Imaging of the AT1 Receptor . [Internet] [Thesis]. University of Ottawa; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10393/19806.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Antoun R. Characterization of [11C]Methyl-Losartan as a Novel Radiotracer for PET Imaging of the AT1 Receptor . [Thesis]. University of Ottawa; 2011. Available from: http://hdl.handle.net/10393/19806

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

19. Farag, Adam Helmy. Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient.

Degree: 2020, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/7503

► According to the World Health Organization (WHO) report in 2019, cardiovascular diseases (CVD) cause 52% of all illness-related deaths globally and are considered to be… (more)

Subjects/Keywords: Cardiovascular imaging; PET/MRI system; attenuation correction coefficient; Radiofrequency phased arrays; acceleration factor; geometry-factor.; Engineering Physics; Medical Biophysics

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APA (6^th Edition):

Farag, A. H. (2020). Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/7503

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Farag, Adam Helmy. “Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient.” 2020. Thesis, University of Western Ontario. Accessed January 19, 2021. https://ir.lib.uwo.ca/etd/7503.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Farag, Adam Helmy. “Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient.” 2020. Web. 19 Jan 2021.

Vancouver:

Farag AH. Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient. [Internet] [Thesis]. University of Western Ontario; 2020. [cited 2021 Jan 19]. Available from: https://ir.lib.uwo.ca/etd/7503.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Farag AH. Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient. [Thesis]. University of Western Ontario; 2020. Available from: https://ir.lib.uwo.ca/etd/7503

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

20. Khan, Michaela CM. Does an acute Achilles tendon rupture become a patient's Achilles heel in the long-term?.

Degree: 2019, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6771

► It is unknown if deficits in the involved limb following acute Achilles tendon rupture (AATR) persist in the long-term, or differ between patients treated operatively… (more)

Subjects/Keywords: Achilles tendon; rupture; long-term follow up; operative; non-operative; magnetic resonance imaging; Biomechanics; Musculoskeletal System; Sports Sciences; Surgical Procedures, Operative

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APA (6^th Edition):

Khan, M. C. (2019). Does an acute Achilles tendon rupture become a patient's Achilles heel in the long-term?. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Khan, Michaela CM. “Does an acute Achilles tendon rupture become a patient's Achilles heel in the long-term?.” 2019. Thesis, University of Western Ontario. Accessed January 19, 2021. https://ir.lib.uwo.ca/etd/6771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Khan, Michaela CM. “Does an acute Achilles tendon rupture become a patient's Achilles heel in the long-term?.” 2019. Web. 19 Jan 2021.

Vancouver:

Khan MC. Does an acute Achilles tendon rupture become a patient's Achilles heel in the long-term?. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Jan 19]. Available from: https://ir.lib.uwo.ca/etd/6771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Khan MC. Does an acute Achilles tendon rupture become a patient's Achilles heel in the long-term?. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Wollongong

21. Li, Kaiyang. A feasibility study of an ultra high resolution small animal pet scanner and an innovative virtual ring based system matrix for iterative algorithm.

Degree: PhD, 2016, University of Wollongong

URL: 029903 Medical Physics, 099902 Engineering Instrumentation ; https://ro.uow.edu.au/theses/4910

► Positron emission tomography (PET) is a functional imaging technique used in clinical diagnostic applications and biomedical research. It is used as a non-invasive in… (more)

▼ Positron emission tomography (PET) is a functional imaging technique used in clinical diagnostic applications and biomedical research. It is used as a non-invasive in vivo imaging modality to observe biochemical processes in small animal models, in particular for the study of diseases and to assist in the development of new treatments. A common approach to improving the spatial resolution of small animal PET scanners is to reduce the size of scintillation crystals and/or employ high resolution pixellated semiconductor detectors. In this thesis, PETiPIX scanner is designed to achieve ultra high spatial resolution for imaging mice brains. Four Timepix pixellated silicon detector modules are placed in an edge-on configuration to form a scanner with a field of view (FoV) 15 mm in diameter. Each detector module consists of 256x256 pixels with dimensions of 55x55x300 µm³. Monte Carlo simulations using GEANT4 Application for Tomographic Emission (GATE) were performed to evaluate the feasibility of the PETiPIX design. Simulation results estimate a spatial resolution of 0.26 mm full width at half maximum (FWHM) at the centre of FoV and 0.29 mm FWHM overall spatial resolution with sensitivity of 0.01%. With many of recent small animal PET scanner designs utilising high resolution pixellated semiconductor detectors, the large number of detector elements results in the system matrix - an essential part of statistical iterative reconstruction algorithms - becoming impractically large. A methodology is proposed in this thesis for system matrix modelling which utilises a virtual single-layer detector ring to greatly reduce the size of the system matrix without sacrificing precision. Two methods for populating the system matrix are compared; the first utilises a geometrically-derived system matrix based on Siddon's ray tracer method with the addition of an accurate detector response function, while the second uses Monte Carlo simulation to populate the system matrix. The effectiveness of both variations of the proposed technique is demonstrated via simulations of PETiPIX. Compression factors of 5x10⁷ and 2:5x10⁷ are achieved using this methodology for the system matrices produced using the geometric and Monte Carlo-based approaches, respectively, requiring a total of 0.5-1.2 GB of memory-resident storage. Images reconstructed from Monte Carlo simulations of various point source and phantom models, produced using system matrices generated via both geometric and simulation methods, are used to evaluate the quality of the resulting system matrix. The Monte Carlo-based system matrix is shown to provide the best image quality at the cost of substantial one-off computational effort and a lower compression factor. In addition, a straightforward extension of the virtual ring method to a three dimensional virtual cylinder is demonstrated using a 3D DoI PET scanner.

Subjects/Keywords: small animal PET; system matrix

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APA (6^th Edition):

Li, K. (2016). A feasibility study of an ultra high resolution small animal pet scanner and an innovative virtual ring based system matrix for iterative algorithm. (Doctoral Dissertation). University of Wollongong. Retrieved from 029903 Medical Physics, 099902 Engineering Instrumentation ; https://ro.uow.edu.au/theses/4910

Chicago Manual of Style (16^th Edition):

Li, Kaiyang. “A feasibility study of an ultra high resolution small animal pet scanner and an innovative virtual ring based system matrix for iterative algorithm.” 2016. Doctoral Dissertation, University of Wollongong. Accessed January 19, 2021. 029903 Medical Physics, 099902 Engineering Instrumentation ; https://ro.uow.edu.au/theses/4910.

MLA Handbook (7^th Edition):

Li, Kaiyang. “A feasibility study of an ultra high resolution small animal pet scanner and an innovative virtual ring based system matrix for iterative algorithm.” 2016. Web. 19 Jan 2021.

Vancouver:

Li K. A feasibility study of an ultra high resolution small animal pet scanner and an innovative virtual ring based system matrix for iterative algorithm. [Internet] [Doctoral dissertation]. University of Wollongong; 2016. [cited 2021 Jan 19]. Available from: 029903 Medical Physics, 099902 Engineering Instrumentation ; https://ro.uow.edu.au/theses/4910.

Council of Science Editors:

Li K. A feasibility study of an ultra high resolution small animal pet scanner and an innovative virtual ring based system matrix for iterative algorithm. [Doctoral Dissertation]. University of Wollongong; 2016. Available from: 029903 Medical Physics, 099902 Engineering Instrumentation ; https://ro.uow.edu.au/theses/4910

Boston University

22. Wilson, Colin Michael. Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies.

Degree: MA, Radiology, 2011, Boston University

URL: http://hdl.handle.net/2144/33592

► The standardized uptake value (SUV) is increasingly being used for diagnosis, staging, and monitoring disease in clinical oncology. Comparing tumor SUV to background SUV is… (more)

Subjects/Keywords: Clinical oncology; PET scans; FDG PET/CT imaging

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APA (6^th Edition):

Wilson, C. M. (2011). Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/33592

Chicago Manual of Style (16^th Edition):

Wilson, Colin Michael. “Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies.” 2011. Masters Thesis, Boston University. Accessed January 19, 2021. http://hdl.handle.net/2144/33592.

MLA Handbook (7^th Edition):

Wilson, Colin Michael. “Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies.” 2011. Web. 19 Jan 2021.

Vancouver:

Wilson CM. Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies. [Internet] [Masters thesis]. Boston University; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2144/33592.

Council of Science Editors:

Wilson CM. Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies. [Masters Thesis]. Boston University; 2011. Available from: http://hdl.handle.net/2144/33592

University of Adelaide

23. Dmochowska, Nicole. Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease.

Degree: 2019, University of Adelaide

URL: http://hdl.handle.net/2440/125041

► Inflammatory bowel disease (IBD) is a chronic, relapsing and remitting inflammatory condition of the gastrointestinal tract. The diagnosis and monitoring of IBD is reliant on… (more)

▼ Inflammatory bowel disease (IBD) is a chronic, relapsing and remitting inflammatory condition of the gastrointestinal tract. The diagnosis and monitoring of IBD is reliant on endoscopic techniques which are invasive and do not provide quantification. Molecular imaging approaches such as immuno-PET have superior sensitivity and provide quantitative information of the entire body. Immuno-PET combines the superior target selectivity provided by antibodies with the sensitivity of PET. This thesis outlines the development of two novel radiolabelled antibody tracers against intestinal inflammation in a preclinical model of IBD and one novel tracer against intestinal fibrosis in a model of chronic murine IBD. Symptom flare in IBD typically corresponds with an increased activation of innate immune pathways. We aimed to compare immuno-PET of the innate immune mediators IL-1β and CD11b against standard 18F-FDG and MRI to detect colonic inflammation. For visualising intestinal inflammation, 89Zr-α-IL-1β and 89Zr-α-CD11b immuno-PET detected colonic inflammation, as did 18F-FDG, and all PET tracers were more sensitive than MRI. While 18F-FDG volumes of interest correlated with colitis severity and a strong trend was observed with 89Zr-α-IL-1β, no correlation was observed for 89Zr-α-CD11b or MRI. 89Zr-α-IL-1β was distributed mainly to the gastrointestinal tract, while 89Zr-α-CD11b was distributed in more tissue types. Intestinal fibrosis is one of the most common complications of IBD, with severe fibrosis leading to stricture and stenosis in approximately 30% of patients. Currently, intestinal fibrosis is diagnosed and monitored using endoscopies and MRI. Fibrosis is characterised by the excessive deposition of extracellular matrix (ECM) as a result of multiple periods of inflammation and subsequent healing, as seen in IBD and murine colitis. Matrix metalloproteinases (MMP) play a large role in fibrogenic pathways by regulating the deposition of ECM during tissue renewal. MMP-9 is found to be elevated in fibrotic tissue resected from IBD patients and in preclinical models of intestinal fibrosis. We aimed to visualise intestinal fibrosis by targeting pro-MMP-9 using f(ab’)2 antibody fragments, radiolabelled with zirconium-89. This was the first immuno-PET study of fibrosis in any tissue in a preclinical or clinical setting. In our preclinical model of chronic IBD, 89Zr-pro-MMP-9- f(ab’)2 successfully detected intestinal fibrosis in the absence of inflammation. Furthermore, immuno-PET and biodistribution studies indicated that the kidneys became fibrotic after multiple rounds of DSS. This was further confirmed by an increase in collagen and pro-MMP- 9 levels in the kidneys, in the absence of elevated immune markers. As the mechanisms underlying fibrosis are similar across all organs, immuno-PET of pro-MMP-9 may be a valuable addition to the detection of fibrosis in all tissues. Additionally, development of these technologies for human subjects will provide a less invasive approach than endoscopy for diagnosing and monitoring IBD. Advisors/Committee Members: Hughes, Patrick (advisor), Tieu, William (advisor), Smid, Scott (advisor), Takhar, Prab (advisor), School of Medicine (school).

Subjects/Keywords: Molecular imaging; immuno-PET; PET; gastrointestinal; colitis; fibrosis

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APA (6^th Edition):

Dmochowska, N. (2019). Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/125041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dmochowska, Nicole. “Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease.” 2019. Thesis, University of Adelaide. Accessed January 19, 2021. http://hdl.handle.net/2440/125041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dmochowska, Nicole. “Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease.” 2019. Web. 19 Jan 2021.

Vancouver:

Dmochowska N. Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease. [Internet] [Thesis]. University of Adelaide; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2440/125041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dmochowska N. Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease. [Thesis]. University of Adelaide; 2019. Available from: http://hdl.handle.net/2440/125041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

24. McKinley, Eliot Thomas. FLT PET in colorectal cancer.

Degree: PhD, Biomedical Engineering, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/11047

► Biomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. With an increasing reliance on molecularly targeted therapies, there… (more)

▼ Biomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. With an increasing reliance on molecularly targeted therapies, there remains an equally critical challenge to develop and validate specific biomarkers that reflect target inhibition, pathway inactivation, and predict overall clinical response. Most biomarkers utilized in oncology studies require tissue sampling which is highly susceptible to sampling error due and bias from heterogeneity. These limitations highlight a critical need to accelerate the translation of novel imaging approaches that are capable of reporting cellular and molecular responses of tumor cells to therapy. Presently, a major impediment to the clinical translation of novel imaging methodology is a lack of understanding of how targeted therapy can affect uptake of molecular probes and a lack appropriate validation studies conducted within relevant biological contexts. This dissertation seeks to elucidate molecular determinants that affect 3’-deoxy-3’[18F]-fluorothymidine ([18F]-FLT) PET imaging as a biomarker of response to targeted therapeutics in colorectal cancer (CRC) in both pre-clinical models and in patients. Using pre-clinical mouse models, [18F]-FLT PET was shown to measure TK1 protein levels in a tumor, was blind to utilization of the de novo pathway of thymidine synthesis, and may not correlate with Ki67 IHC measures of total cellular proliferation in a prognostic setting. Also is preclinical mouse models of CRC, [18F]-FLT was shown to serve as an early PET biomarker that may be sensitive to activation of pro-survival mechanisms that may predict tumors that are more likely to resist treatment and ultimately may be more prone to recurrence. In the clinical setting, [18F]-FLT PET was shown to correlate with treatment response in KRAS mutant rectal cancers after EGFR targeted therapy and chemoradiotherapy. Each of these components advance the understanding the strengths and weaknesses of [18F]-FLT and how [18F]-FLT PET can best be utilized in clinical practice Advisors/Committee Members: Robert J. Coffey (committee member), John C. Gore (committee member), Melissa C. Skala (committee member), M. Kay Washington (committee member), H. Charles Manning (Committee Chair).

Subjects/Keywords: FLT; PET; colorectal cancer; imaging; oncology

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APA (6^th Edition):

McKinley, E. T. (2013). FLT PET in colorectal cancer. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11047

Chicago Manual of Style (16^th Edition):

McKinley, Eliot Thomas. “FLT PET in colorectal cancer.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed January 19, 2021. http://hdl.handle.net/1803/11047.

MLA Handbook (7^th Edition):

McKinley, Eliot Thomas. “FLT PET in colorectal cancer.” 2013. Web. 19 Jan 2021.

Vancouver:

McKinley ET. FLT PET in colorectal cancer. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1803/11047.

Council of Science Editors:

McKinley ET. FLT PET in colorectal cancer. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/11047

University of Toronto

25. MacDonald, Thomas. Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles.

Degree: 2013, University of Toronto

URL: http://hdl.handle.net/1807/43251

►

Porphyrins are naturally occurring molecules. Porphysomes are simple multimodal nanoparticles that derive their multifunctionality from porphyrin-based building-blocks. While previous studies have probed their interactions with… (more)

Subjects/Keywords: Nanomedicine; Imaging; Cancer; PET; MRI; Porphyrins; 491

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APA (6^th Edition):

MacDonald, T. (2013). Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/43251

Chicago Manual of Style (16^th Edition):

MacDonald, Thomas. “Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles.” 2013. Masters Thesis, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/43251.

MLA Handbook (7^th Edition):

MacDonald, Thomas. “Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles.” 2013. Web. 19 Jan 2021.

Vancouver:

MacDonald T. Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/43251.

Council of Science Editors:

MacDonald T. Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/43251

Rice University

26. Valiollahzadeh, Majid. Compressive Sensing in Positron Emission Tomography (PET) Imaging.

Degree: PhD, Engineering, 2015, Rice University

URL: http://hdl.handle.net/1911/88183

► Positron emission tomography (PET) is a nuclear medicine functional imaging modality, applicable to several clinical problems, but especially in detecting the metabolic activity (as in… (more)

▼ Positron emission tomography (PET) is a nuclear medicine functional imaging modality, applicable to several clinical problems, but especially in detecting the metabolic activity (as in cancer). PET scanners use multiple rings of gamma ray detectors that surround the patient. These scanners are quite expensive (1-3 million dollars), therefore a technology that would allow the reduction in the number of detectors per ring without affecting image quality, could reduce the scanner cost, thereby making this imaging modality more accessible to patients. In this thesis , a mathematical technique known as compressive sensing is applied in an effort to decrease the number of detectors required, while maintaining good image quality. A CS model was developed based on a combination of gradient magnitude and wavelet domains to recover missing observations associated with PET data acquisition. The CS model also included a Poisson-distributed noise term. The overall model was formulated as an optimization problem wherein the cost function was a weighted sum of the total variation and the L1-norm of the wavelet coefficients. Subsequently, the cost function was minimized subject to the CS model equations, the partially observed data, and a penalty function for noise suppression (the Poisson log-likelihood function). We refer to the complete model as the WTV model. This thesis also explores an alternative reconstruction method, wherein a different CS model based on an adaptive dictionary learning (DL) technique for data recovery in PET imaging was developed. Specifically, a PET image is decomposed into small overlapped patches and the dictionary is learned from these overlapped patches. The technique has good sparsifying properties and the dictionary tends to capture local as well as structural similarities, without sacrificing resolution. Recovery is accomplished in two stages: a dictionary learning phase followed by a reconstruction step. In addition to developing optimized CS reconstruction, this thesis also investigated: (a) the limits of detector removal when using the DL CS reconstruction algorithm; and (b) the optimal detector removal configuration per ring while minimizing the impact on image quality following recovery using the CS model. Results of these investigations can serve to help make PET scanners more affordable while maintaining image quality. These results can also be used to improve patient throughput by redesigning scanners so that removed detectors can be placed in axial extent to image a larger portion of the body. This will help increase scanner throughput hence improve scanner efficiency as well as patient discomfort due to long scan time. Advisors/Committee Members: Clark, John (advisor), Veeraghavan, Ashok (committee member), Jacot, Jeffrey (committee member), Mawlawi, Osama (committee member), kelly, Kevin (committee member).

Subjects/Keywords: Compressive sensing; PET imaging; signal processing

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APA (6^th Edition):

Valiollahzadeh, M. (2015). Compressive Sensing in Positron Emission Tomography (PET) Imaging. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/88183

Chicago Manual of Style (16^th Edition):

Valiollahzadeh, Majid. “Compressive Sensing in Positron Emission Tomography (PET) Imaging.” 2015. Doctoral Dissertation, Rice University. Accessed January 19, 2021. http://hdl.handle.net/1911/88183.

MLA Handbook (7^th Edition):

Valiollahzadeh, Majid. “Compressive Sensing in Positron Emission Tomography (PET) Imaging.” 2015. Web. 19 Jan 2021.

Vancouver:

Valiollahzadeh M. Compressive Sensing in Positron Emission Tomography (PET) Imaging. [Internet] [Doctoral dissertation]. Rice University; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1911/88183.

Council of Science Editors:

Valiollahzadeh M. Compressive Sensing in Positron Emission Tomography (PET) Imaging. [Doctoral Dissertation]. Rice University; 2015. Available from: http://hdl.handle.net/1911/88183

University of Melbourne

27. HASKALI, MOHAMMAD. Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer.

Degree: 2014, University of Melbourne

URL: http://hdl.handle.net/11343/52367

► Positron Emission Tomography (PET) is a molecular imaging technique, requiring biologically active molecules that are radiolabelled with positron emitting radionuclides. [18F]Fluorine is considered an ideal… (more)

▼ Positron Emission Tomography (PET) is a molecular imaging technique, requiring biologically active molecules that are radiolabelled with positron emitting radionuclides. [18F]Fluorine is considered an ideal radionuclide utilised for PET imaging. When high affinity peptides are labelled with [18F]fluorine, they form an excellent targeting molecule that can be utilised to characterise tumours using PET imaging. This project investigated an improved radiosynthesis route for the production of 4-nitrophenyl 2-[18F]fluoropropionate ([18F]NFP), a peptide [18F]fluorination synthon. [18F]NFP was produced in a single radiochemical step and the synthesis was fully automated on both TRACERLab FXFN and iPHASE FlexLab radiosynthesis modules. The automated radiosynthesis of [18F]NFP was accomplished in 45 min and in 29% decay corrected yield. The improved synthesis route of [18F]NFP, allowed the synthesis of the gold standard tracer for αvβ3 PET imaging [18F]FP-GalactoRGD in 7% n.d.c. yield and in less than half of the reported synthesis time.1 Furthermore, [18F]FPPRGD2 was prepared in 4% n.d.c. yield from free fluoride within 94–105 min . [18F]FP-GalactoRGD and [18F]FPPRGD2 were compared in-vivo under similar conditions. [18F]FPPRGD2 exhibited improved biological character in our model for αvβ3 expression. Moreover, novel RGD peptides were synthesised for the targeting of metastatic tumours. The biological properties of the novel RGD ligands were modified by site specific sulfonation of tyrosine. Sulfonation of tyrosine was accomplished utilising readily available chlorosulfonic acid and trifluoroacetic acid. The corresponding sulfonated peptides were generated in good chemical yields (60%). Sulfonated peptides were subsequently labelled with [18F]NFP and their biological properties were investigated. This methodology was employed to prepare [18F]FP-c(RGDy(SO3)K) and [18F]FP-E-c(RGDy(SO3)K)2. [18F]FP-c(RGDy(SO3)K) exhibited comprable biological properties to [18F]FP-GalactoRGD. However, [18F]FP-E-c(RGDy(SO3)K)2 demonstrated improved biological properties over all other peptides examined for the imaging of αvβ3 Integrins in our models. The project also exploited the radiolabelling of biomolecules targetting apoptotic cells. Annexin V was labelled by [18F]SFB, to generate the [18F]FB-Annexin V, an imaging agent for in-vivo apoptosis measurement. Furthermore, duramycin (an apoptosis targeting peptide) was initially labelled with [18F]SFB to generate [18F]FB-duramycin in 16% n.d.c. yield from [18F]SFB within 150–175 min. [18F]FB-duramycin exhibited high liver accumulation presumably as a result of its hydrophobic nature. The hydrophilicity of duramycin was modified by mono-glycosylation and latter labelling with [18F]NFP to form [18F]FP-galacto-duramycin in 45% n.d.c. from [18F]NFP within 90–100 min. [18F]FP-galacto-duramycin presented improved biological properties over [18F]FB-duramycin as demonstrated by small animal imaging. The biological properties of duramycin were further enhanced by di-glycosylation. The…

Subjects/Keywords: radiochemistry; PET imaging; radiolabelling; 18-fluorine; peptides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

HASKALI, M. (2014). Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/52367

Chicago Manual of Style (16^th Edition):

HASKALI, MOHAMMAD. “Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer.” 2014. Doctoral Dissertation, University of Melbourne. Accessed January 19, 2021. http://hdl.handle.net/11343/52367.

MLA Handbook (7^th Edition):

HASKALI, MOHAMMAD. “Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer.” 2014. Web. 19 Jan 2021.

Vancouver:

HASKALI M. Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer. [Internet] [Doctoral dissertation]. University of Melbourne; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/11343/52367.

Council of Science Editors:

HASKALI M. Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer. [Doctoral Dissertation]. University of Melbourne; 2014. Available from: http://hdl.handle.net/11343/52367

Washington University in St. Louis

28. Peng, Xin. Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET.

Degree: PhD, Chemistry, 2013, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/art_sci_etds/162

► Amide linkages are favored in medicinal chemistry to build molecule libraries because of their vast presence in biomolecules, such as peptides and proteins. In… (more)

▼ Amide linkages are favored in medicinal chemistry to build molecule libraries because of their vast presence in biomolecules, such as peptides and proteins. In addition, molecules with amide linkages have more flexible conformation, thus these molecules are more likely to orient to a conformation that fits a protein's binding pocket. Our group has been engaging in developing selective dopamine D3 receptor ligands and sigma-2 receptor ligands. In the past few years, amide linkages were employed in the majority of the dopamine D3 and sigma-2 ligands we have developed. Many of the benzamide ligands showed promising in vitro data, but few exhibit great in vivo characteristics. One of the reasons is that amide linkage was identified as a potential metabolic site for in vivo modification by proteases. My research explored new synthons as replacements for the amide linkages in dopamine D3 receptor ligands and sigma-2 receptor ligands. 5-Membered heterocycle rings, such as triazoles and isoxazoles, have been reported to exhibit resistance to metabolic degradation and represent novel isosteric substitution of an amide linkage. In addition, the hetero atoms may participate in hydrogen bonding and dipole-dipole interactions, which could result in more favorable receptor binding properties. The second step of the research reported in this thesis is the development of selective dopamine D3 receptor tracers and sigma-2 receptor tracers for non-invasive Positron Emission Tomography (PET). Dopamine D3 receptors play an important role in Central Nervous System (CNS) and may be associated with several CNS diseases and behavioral disorders, including psychostimulant abuse. Sigma-2 receptors have been shown to be expressed in a variety of human tumors, in particular, those of breast, melanoma, non-small-cell lung carcinoma, brain, prostate and tumors of neural origin. Sigma-2 receptors are the only validated biomarker for imaging the proliferative status of tumor cells. In this thesis, two dopamine D3 ligands were radiolabeled and evaluated in non-human primate microPET studies. Two sigma-2 ligands were also radiolabeled and evaluated in rodents bearing tumor cells. We have identified the two sigma-2 tracers [11C]PX-II-116]and [18F]PX-II-120]as promising PET tracers for imaging proliferative status of tumor cells. Advisors/Committee Members: Robert H Mach, Joshua Maurer, Joseph Ackerman, Peter Gaspar, Suzanne Lapi, John-Stephen Taylor.

Subjects/Keywords: cancer; CNS; Imaging; PET; Radiotracers; Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peng, X. (2013). Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/art_sci_etds/162

Chicago Manual of Style (16^th Edition):

Peng, Xin. “Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET.” 2013. Doctoral Dissertation, Washington University in St. Louis. Accessed January 19, 2021. https://openscholarship.wustl.edu/art_sci_etds/162.

MLA Handbook (7^th Edition):

Peng, Xin. “Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET.” 2013. Web. 19 Jan 2021.

Vancouver:

Peng X. Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2013. [cited 2021 Jan 19]. Available from: https://openscholarship.wustl.edu/art_sci_etds/162.

Council of Science Editors:

Peng X. Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET. [Doctoral Dissertation]. Washington University in St. Louis; 2013. Available from: https://openscholarship.wustl.edu/art_sci_etds/162

University of Edinburgh

29. Joshi, Nikhil Vilas. Novel molecular imaging of cardiovascular disease in man.

Degree: PhD, 2016, University of Edinburgh

URL: http://hdl.handle.net/1842/25394

► Cardiovascular disease remains the commonest cause of death worldwide. The majority of deaths are caused by atherosclerotic plaque rupture with resultant myocardial infarction or stroke,… (more)

▼ Cardiovascular disease remains the commonest cause of death worldwide. The majority of deaths are caused by atherosclerotic plaque rupture with resultant myocardial infarction or stroke, or rupture of abdominal aortic aneurysms. Conventional imaging modalities have consistently failed to identify atherosclerotic plaques or aneurysms with high-risk pathological features that are at highest risk of rupture or progression. The development of modern molecular imaging techniques targeted at these features could lead to the identification of such high-risk plaques and aneurysms in vivo and guide the development of novel treatment strategies. The aim of this thesis was to evaluate whether novel molecular modalities have a role in providing new insights into biological disease processes, and identify high-risk plaques and aneurysms. Using positron emission tomography-computed tomography (PET-CT), 18F-fluorodeoxyglucose and 18F-fluoride were utilised as markers of metabolic inflammation and active calcification. Cellular inflammation was assessed using ultrasmall superparamagnetic particles of iron oxide (USPIO) enhanced magnetic resonance imaging (MRI). In a prospective trial, 80 patients with myocardial infarction (n=40) and stable angina (n=40) underwent 18F-fluoride and 18F-fluorodeoxyglucose PET-CT, and invasive coronary angiography (Chapter 3). Intense 18F-fluoride uptake localised to recently ruptured plaque in patients with acute myocardial infarction. In patients with stable coronary artery disease, 18F-fluoride uptake identified coronary plaques with high-risk features on intravascular ultrasound. 18F-fluoride PET-CT is the first noninvasive imaging method to identify and localise ruptured and high-risk coronary plaques. Aortic vascular uptake of 18F- fluorodeoxyglucose was studied in patients with myocardial infarction and stable angina (Chapter 4). In a separate outcome of 1,003 patients enrolled in the Global Registry of Acute Coronary Events, we further evaluated whether infarct size predicted recurrent coronary events. Patients with myocardial infarction had higher remote atherosclerotic tracer uptake that correlated with the degree of myocardial necrosis, and exceeded that observed in patients with stable coronary disease. The outcome cohort demonstrated that patients with higher degree of myocardial necrosis had the highest risk of early recurrent myocardial infarction. This supports the hypothesis that acute myocardial infarction exacerbates systemic atherosclerotic inflammation and remote plaque destabilization: myocardial infarction begets myocardial infarction. In a prospective imaging cohort, the role inflammation and calcification was assessed in 63 patients with abdominal aortic aneurysms and 19 age and sex matched patients with atherosclerosis (Chapter 5). Compared to non-aneurysmal segments, enhanced inflammation and calcification was observed within the wall of aortic aneurysmal segments. In comparison to matched controls with atherosclerosis, the entire aorta in those with aortic aneurysm appears…

Subjects/Keywords: 616.1; atherosclerosis; aneurysm; molecular imaging; PET-CT

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Joshi, N. V. (2016). Novel molecular imaging of cardiovascular disease in man. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/25394

Chicago Manual of Style (16^th Edition):

Joshi, Nikhil Vilas. “Novel molecular imaging of cardiovascular disease in man.” 2016. Doctoral Dissertation, University of Edinburgh. Accessed January 19, 2021. http://hdl.handle.net/1842/25394.

MLA Handbook (7^th Edition):

Joshi, Nikhil Vilas. “Novel molecular imaging of cardiovascular disease in man.” 2016. Web. 19 Jan 2021.

Vancouver:

Joshi NV. Novel molecular imaging of cardiovascular disease in man. [Internet] [Doctoral dissertation]. University of Edinburgh; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1842/25394.

Council of Science Editors:

Joshi NV. Novel molecular imaging of cardiovascular disease in man. [Doctoral Dissertation]. University of Edinburgh; 2016. Available from: http://hdl.handle.net/1842/25394

University of Georgia

30. Thom, Sarah Elisabeth. The speech-related neural activity of individual stutterers and groups of stutterers.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/25070

► Purpose: To (a) investigate neural activity of individuals who stutter, and (b) compare individual results with previously published data from groups of stutterers. Method: Three… (more)

Subjects/Keywords: Stuttering; PET; brain imaging; inter-subject averaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thom, S. E. (2014). The speech-related neural activity of individual stutterers and groups of stutterers. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thom, Sarah Elisabeth. “The speech-related neural activity of individual stutterers and groups of stutterers.” 2014. Thesis, University of Georgia. Accessed January 19, 2021. http://hdl.handle.net/10724/25070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thom, Sarah Elisabeth. “The speech-related neural activity of individual stutterers and groups of stutterers.” 2014. Web. 19 Jan 2021.

Vancouver:

Thom SE. The speech-related neural activity of individual stutterers and groups of stutterers. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10724/25070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thom SE. The speech-related neural activity of individual stutterers and groups of stutterers. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations