subject:(Substance P)

University of Iowa

1. Maduka, Uche Patrick. Elucidating mechanisms by which substance P in the RVM contributes to the maintenance of pain following inflammatory injury.

Degree: PhD, Pharmacology, 2013, University of Iowa

URL: https://ir.uiowa.edu/etd/5019

► Chronic pain is a major healthcare concern that directly affects over one hundred million people in the United States alone. While current treatment options… (more)

Subjects/Keywords: Inflammatory Pain; Rostral Ventromedial Medulla; Substance P; Substance P Release; Pharmacology

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APA (6^th Edition):

Maduka, U. P. (2013). Elucidating mechanisms by which substance P in the RVM contributes to the maintenance of pain following inflammatory injury. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/5019

Chicago Manual of Style (16^th Edition):

Maduka, Uche Patrick. “Elucidating mechanisms by which substance P in the RVM contributes to the maintenance of pain following inflammatory injury.” 2013. Doctoral Dissertation, University of Iowa. Accessed February 27, 2021. https://ir.uiowa.edu/etd/5019.

MLA Handbook (7^th Edition):

Maduka, Uche Patrick. “Elucidating mechanisms by which substance P in the RVM contributes to the maintenance of pain following inflammatory injury.” 2013. Web. 27 Feb 2021.

Vancouver:

Maduka UP. Elucidating mechanisms by which substance P in the RVM contributes to the maintenance of pain following inflammatory injury. [Internet] [Doctoral dissertation]. University of Iowa; 2013. [cited 2021 Feb 27]. Available from: https://ir.uiowa.edu/etd/5019.

Council of Science Editors:

Maduka UP. Elucidating mechanisms by which substance P in the RVM contributes to the maintenance of pain following inflammatory injury. [Doctoral Dissertation]. University of Iowa; 2013. Available from: https://ir.uiowa.edu/etd/5019

University of Guelph

2. Martin, Christina. Distribution of Neurokinin 2 and 3 Receptor mRNA in the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Expression of Neurokinin 1, 2 and 3 Receptor mRNA in the Jejunum.

Degree: MS, Department of Clinical Studies, 2014, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8109

► ABSTRACT DISTRIBUTION OF NEUROKININ 2 AND 3 RECEPTOR mRNA IN THE NORMAL EQUINE GASTROINTESTINAL TRACT AND EFFECT OF INFLAMMATION ON EXPRESSION OF NEUROKININ 1, 2… (more)

▼ ABSTRACT DISTRIBUTION OF NEUROKININ 2 AND 3 RECEPTOR mRNA IN THE NORMAL EQUINE GASTROINTESTINAL TRACT AND EFFECT OF INFLAMMATION ON EXPRESSION OF NEUROKININ 1, 2 AND 3 RECEPTOR mRNA IN THE JEJUNUM Dr. Christina E. W. Martin Advisor: Dr. Judith B. Koenig This study is an investigation of the distribution of neurokinin receptors in the equine gastrointestinal tract. The objectives of this research were to determine the relative distribution of neurokinin 2 (NK2) and 3 (NK3) receptor mRNA in the normal equine gastrointestinal tract, and also to determine changes in neurokinin 1 (NK1), NK2 and NK3 receptor mRNA expression after ischemia/reperfusion injury or intraluminal distension in the jejunum. Samples from 9 regions in the gastrointestinal tract (duodenum, jejunum, ileum, caecum, right ventral colon, left ventral colon, pelvic flexure, right dorsal colon and left dorsal colon) were harvested from 5 mature healthy horses, euthanized for reasons unrelated to the gastrointestinal tract, for the study of NK2 and NK3 mRNA distribution in the normal intestinal tract. To evaluate the effect of inflammation on NK1, NK2 and NK3 receptor mRNA distribution, samples were taken from 6 horses whose jejunum underwent one of three treatments: control (sham-operated), intraluminal distension (ILD) or ischemic strangulation obstruction and subsequent reperfusion injury (ISO). NK2 and NK3 receptor primers were designed and real-time PCR was used to quantify NK1 (primers previously described), NK2 and NK3 receptor mRNA expression in the treatment groups described above. In healthy horses, NK2 mRNA expression in the small intestine was highest in the duodenum and lowest in the ileum. NK2 mRNA expression in the large intestine was highest in the caecum. NK3 mRNA expression was more variable between individuals than NK2 expression overall. No significant difference was found between concentrations of NK1 or NK3 receptor mRNA between control, ILD or ISO treatments. A trend was noted for NK1 mRNA to be lower in ILD treatments than control. For NK2 receptor mRNA, ILD and ISO values were significantly lower than that of control. Tachykinin agonists and antagonists have shown therapeutic value in intestinal inflammation and motility disorders in laboratory animals and humans. Neurokinin receptor mRNA is present in the equine intestinal tract. Relative levels appear to be altered by inflammation, although the clinical significance of this finding needs to be further evaluated. The current study suggests that tachykinin therapy may have a potential utility in the medical treatment of equine post-operative ileus and equine colic, however further investigation into the physiology of neurokinin receptors in the horse is warranted. Advisors/Committee Members: Koenig, Judith (advisor).

Subjects/Keywords: tachykinin; neurokinin; equine; gastrointestinal tract; substance P

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APA (6^th Edition):

Martin, C. (2014). Distribution of Neurokinin 2 and 3 Receptor mRNA in the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Expression of Neurokinin 1, 2 and 3 Receptor mRNA in the Jejunum. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8109

Chicago Manual of Style (16^th Edition):

Martin, Christina. “Distribution of Neurokinin 2 and 3 Receptor mRNA in the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Expression of Neurokinin 1, 2 and 3 Receptor mRNA in the Jejunum.” 2014. Masters Thesis, University of Guelph. Accessed February 27, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8109.

MLA Handbook (7^th Edition):

Martin, Christina. “Distribution of Neurokinin 2 and 3 Receptor mRNA in the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Expression of Neurokinin 1, 2 and 3 Receptor mRNA in the Jejunum.” 2014. Web. 27 Feb 2021.

Vancouver:

Martin C. Distribution of Neurokinin 2 and 3 Receptor mRNA in the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Expression of Neurokinin 1, 2 and 3 Receptor mRNA in the Jejunum. [Internet] [Masters thesis]. University of Guelph; 2014. [cited 2021 Feb 27]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8109.

Council of Science Editors:

Martin C. Distribution of Neurokinin 2 and 3 Receptor mRNA in the Normal Equine Gastrointestinal Tract and Effect of Inflammation on Expression of Neurokinin 1, 2 and 3 Receptor mRNA in the Jejunum. [Masters Thesis]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8109

University of Adelaide

3. Leonard, Anna Victoria. Characterising the role of substance P following traumatic spinal cord injury.

Degree: 2012, University of Adelaide

URL: http://hdl.handle.net/2440/87149

► Spinal cord injury (SCI) is a devastating injury that commonly results in permanent physical disability. The highest incidence of SCI occurs in younger populations, causing… (more)

▼ Spinal cord injury (SCI) is a devastating injury that commonly results in permanent physical disability. The highest incidence of SCI occurs in younger populations, causing an enormous financial burden to both individuals and society amounting to almost $1 billion annually within Australia spent on hospitalisation, treatment and rehabilitation of spinal cord injured individuals. To date, an effective clinical treatment for SCI remains elusive, highlighting the need for research aimed at developing therapeutic interventions that improve functional outcome. Spinal cord edema is recognised as a common complication of SCI which continues to develop, spreading in a rostrocaudal direction days after injury, resulting in greater tissue damage and functional deficits. Reducing edema following SCI is therefore of utmost importance and represents an attractive target for therapeutic intervention. Substance P (SP) is a neuropeptide known to facilitate the process of neurogenic inflammation, which has previously been shown to result in blood brain barrier (BBB) disruption and subsequent edema development following both traumatic brain injury (TBI) and stroke. Furthermore, inhibition of the high-affinity SP receptor, the tachykinin NK1 receptor, resulted in reduced BBB permeability, edema and improved functional outcome in both of these conditions. Accordingly, the current thesis sought to determine whether SP played a similar role as a mediator of neurogenic inflammation following traumatic SCI. Immunohistochemical assessment of human SCI demonstrated a loss of SP from the dorsal horn region, suggesting that SP release increased following injury. NK1 receptor immunoreactivity was also initially increased post-injury before declining, indicating that receptor activation and subsequent internalisation occurred. Assessment of various open experimental injury models, including the weight drop, hemisection and clip compression models, demonstrated similar SP immunoreactivity as that observed in human tissue, although NK1 receptor immunoreactivity varied in localisation and response to injury. These results highlighted the need for experimental models to accurately replicate the primary injury mechanisms observed clinically, especially the closed environment rather than the open nature of most experimental models. The balloon compression model was subsequently employed for the remainder of the study, given its closed nature and its ability to mimic primary injury mechanisms such as an initial impact followed by persisting compression. This model also proved to replicate many other facets of human injury such as severe hemorrhage, axonal injury, neuronal loss, microglial activation, as well as increased BSCB disruption, edema, intrathecal pressure (ITP) and reduced functional outcome. Balloon compression induced SCI was also associated with reduced SP immunoreactivity, suggesting increased SP release, and increased NK1 receptor immunoreactivity. Such observations implicate a potential role for SP in mediating neurogenic inflammation… Advisors/Committee Members: Vink, Robert (advisor), Blumbergs, Peter Charles (advisor), School of Medical Sciences (school).

Subjects/Keywords: spinal cord injury; substance P; neurogenic inflammation

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APA (6^th Edition):

Leonard, A. V. (2012). Characterising the role of substance P following traumatic spinal cord injury. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/87149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leonard, Anna Victoria. “Characterising the role of substance P following traumatic spinal cord injury.” 2012. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/87149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leonard, Anna Victoria. “Characterising the role of substance P following traumatic spinal cord injury.” 2012. Web. 27 Feb 2021.

Vancouver:

Leonard AV. Characterising the role of substance P following traumatic spinal cord injury. [Internet] [Thesis]. University of Adelaide; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/87149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leonard AV. Characterising the role of substance P following traumatic spinal cord injury. [Thesis]. University of Adelaide; 2012. Available from: http://hdl.handle.net/2440/87149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

4. Kleinig, Timothy John. The role of substance P in experimental intracerebral haemorrhage.

Degree: 2010, University of Adelaide

URL: http://hdl.handle.net/2440/63372

► Background: Elevated levels of substance P (SP) have previously been found following ischaemic stroke and traumatic brain injury. Inhibiting the main SP receptor (neurokinin-1 (NK1))… (more)

▼ Background: Elevated levels of substance P (SP) have previously been found following ischaemic stroke and traumatic brain injury. Inhibiting the main SP receptor (neurokinin-1 (NK1)) reduces oedema and improves functional outcome in both settings. As this thesis details, we hypothesised that SP plays a similarly deleterious role following intracerebral haemorrhage (ICH). We further hypothesised that the post-ICH effects of intracerebral thrombin (which is known to play a major role in post-ICH secondary injury) are at least partly SP-mediated. Thrombin, similarly to SP, is known to play a deleterious role following both ischaemic stroke and traumatic brain injury. Previous research has also demonstrated that thrombin causes cutaneous oedema by an SP-dependent mechanism. Methods: Three hundred and forty three male Sprague-Dawley rats were used, and variously subjected to collagenase ICH, autologous ICH, intracerebral thrombin injection and intracerebral injection of SP. The sequelae of these various injuries was assessed, as well as the effect of antagonists to the main substance P receptor (NK1R), using functional testing, histological analysis, ELISA, real-time RT-PCR, wet-weight dry weight (for assessment of oedema) and Evans blue (for assessment of blood-brain barrier integrity). The effect of prior splenectomy on oedema following ICH was also assessed. Results: Elevated levels of SP were demonstrated post-ICH in the two different ICH models, and localised to astrocytes. Following collagenase ICH, two structurally unrelated NK1R antagonists reduced oedema and blood-brain barrier (BBB) dysfunction, but failed to reduce cellular inflammation, brain lesion volume and functional deficits. Stereotactic thrombin injections caused both oedema and elevated intracerebral SP, however, NK1R antagonism post-intracerebral thrombin failed to reduce brain oedema, largely disproving the hypothesis that thrombin causes intracerebral oedema post-ICH by a SP-dependent mechanism. Supraphysiological levels of SP injected stereotactically caused surprisingly little oedema and BBB dysfunction. Additional exploratory experiments demonstrated that NK1R antagonism did not reduce oedema caused by autologous ICH and also that the oedema-reducing effects of NK1R antagonism following collagenase ICH were abrogated by prior splenectomy. Conclusion: These results demonstrate that the oedematogenic actions of substance P following ICH are complex, and may predominantly be peripherally-mediated. Future experiments are planned to characterise further the role of SP in neuroinflammatory conditions. Advisors/Committee Members: Vink, Robert (advisor), Blumbergs, Peter Charles (advisor), School of Medical Sciences (school).

Subjects/Keywords: substance P; intracerebral haemorrhage; oedema; inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kleinig, T. J. (2010). The role of substance P in experimental intracerebral haemorrhage. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/63372

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kleinig, Timothy John. “The role of substance P in experimental intracerebral haemorrhage.” 2010. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/63372.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kleinig, Timothy John. “The role of substance P in experimental intracerebral haemorrhage.” 2010. Web. 27 Feb 2021.

Vancouver:

Kleinig TJ. The role of substance P in experimental intracerebral haemorrhage. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/63372.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kleinig TJ. The role of substance P in experimental intracerebral haemorrhage. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/63372

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

5. DARMAN, PAUL STEWART. THE SYNTHESIS AND BIOLOGICAL EVALUATION OF ALPHA-MELANOTROPIN AND SUBSTANCE P PEPTIDE ANALOGUES (STRUCTURE, FUNCTION).

Degree: 1985, University of Arizona

URL: http://hdl.handle.net/10150/187929

► To investigate the underlying structural features of the neuropeptides α-melanotropin (α-MSH) and substance P (SP), which are responsible for their biological actions, the following study… (more)

▼ To investigate the underlying structural features of the neuropeptides α-melanotropin (α-MSH) and substance P (SP), which are responsible for their biological actions, the following study was undertaken. By means of side-chain, fragment and conformational restriction analysis, several α-MSH peptides were prepared by solid-phase synthesis and evaluated by the frog and lizard skin bioassays. Using conformational restriction and fragment methods, several SP peptides were synthesized and examined for biological activity on the guinea-pig isolated ileum, rat brain binding and intrathecal injection assay systems. The results with the new α-MSH analogues show that the histidine-6 side-chain is not needed for signal transduction, but is very important for full potency. The tryptophan-9 side-chain is similarly not needed for signal transduction, but is critically important for full potency. The data also indicate that the positions 6 and 9 side-chains are important for full potency because they likely interact with the melanophore receptor, rather than playing a role in conformationally folding the MSH peptide into a pseudocyclic structure. The results also show that the arginine side-chain at position 8 is not particularly important for signal transduction or full potency, but on the lizard skin bioassay this side-chain is implicated in the previously reported prolongation of Nle⁴, D-Phe⁷-α-MSH. The data provided by the SP peptides suggest that the previously postulated pseudocyclic structure of the 5-11 sequence may not be as fundamental to SP activity as heretofore believed. The data suggest that this type of turn conformation may be important for signal transduction, but is apparently not the only requirement for receptor recognition. Finally, the data show that part of the signal transduction message of SP is contained within the 5-8 region of the peptide, but that most of the receptor recognition elements are probably located outside this sequence. Advisors/Committee Members: Bates, Robert B. (committeemember), Forster, Leslie R. (committeemember), Hadley, Mac E. (committeemember), Rupley, John A. (committeemember).

Subjects/Keywords: Neuropeptides.; Substance P.

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APA (6^th Edition):

DARMAN, P. S. (1985). THE SYNTHESIS AND BIOLOGICAL EVALUATION OF ALPHA-MELANOTROPIN AND SUBSTANCE P PEPTIDE ANALOGUES (STRUCTURE, FUNCTION). (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/187929

Chicago Manual of Style (16^th Edition):

DARMAN, PAUL STEWART. “THE SYNTHESIS AND BIOLOGICAL EVALUATION OF ALPHA-MELANOTROPIN AND SUBSTANCE P PEPTIDE ANALOGUES (STRUCTURE, FUNCTION). ” 1985. Doctoral Dissertation, University of Arizona. Accessed February 27, 2021. http://hdl.handle.net/10150/187929.

MLA Handbook (7^th Edition):

DARMAN, PAUL STEWART. “THE SYNTHESIS AND BIOLOGICAL EVALUATION OF ALPHA-MELANOTROPIN AND SUBSTANCE P PEPTIDE ANALOGUES (STRUCTURE, FUNCTION). ” 1985. Web. 27 Feb 2021.

Vancouver:

DARMAN PS. THE SYNTHESIS AND BIOLOGICAL EVALUATION OF ALPHA-MELANOTROPIN AND SUBSTANCE P PEPTIDE ANALOGUES (STRUCTURE, FUNCTION). [Internet] [Doctoral dissertation]. University of Arizona; 1985. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10150/187929.

Council of Science Editors:

DARMAN PS. THE SYNTHESIS AND BIOLOGICAL EVALUATION OF ALPHA-MELANOTROPIN AND SUBSTANCE P PEPTIDE ANALOGUES (STRUCTURE, FUNCTION). [Doctoral Dissertation]. University of Arizona; 1985. Available from: http://hdl.handle.net/10150/187929

6. Lima, Clarice Maria de. Estudo da marcação e biodistribuição da substância P utilizando Lutécio-177 como radiotraçador.

Degree: Mestrado, Tecnologia Nuclear - Aplicações, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-05082011-102555/ ;

► Gliomas malignos são tumores cerebrais primários, resistentes a vários tratamentos, como quimioterapia, radioterapia, indução de apoptose e cirurgia. Uma alternativa para o tratamento dos gliomas… (more)

▼ Gliomas malignos são tumores cerebrais primários, resistentes a vários tratamentos, como quimioterapia, radioterapia, indução de apoptose e cirurgia. Uma alternativa para o tratamento dos gliomas malignos é a terapia radionuclídea. Essa técnica utiliza moléculas radiomarcadas que se ligam seletivamente às células tumorais e nelas depositam dose citotóxica de radiação, provocando a morte das células doentes. A maioria dos protocolos de terapia radionuclídea para tumores cerebrais malignos envolve a administração de peptídeos marcados com radioisótopos emissores -. A substância P (SP) é um neuropeptídeo de 11 aminoácidos, da família das taquicininas, caracterizada pela sequência C-terminal Phe-X-Gly-Leu-Met-NH2. A SP radiomarcada com diferentes radioisótopos, inclusive Lutécio-177, tem sido descrita e proposta para tratamento in vivo de tumores. A SP é o ligante mais importante dos receptores de neuroquinina tipo 1, superexpressos em gliomas malignos. O objetivo deste trabalho foi estudar as condições de marcação de SP-DOTA com 177Lu, a estabilidade do composto marcado e suas propriedades in vitro e in vivo, a fim de desenvolver um protocolo de produção e avaliar o potencial do radiofármaco para terapia de gliomas. As condições de marcação foram otimizadas variando-se temperatura, tempo de reação, atividade de cloreto de lutécio-177 e massa de SP-DOTA e analisou-se a pureza radioquímica das preparações por meio de técnicas cromatográficas. A estabilidade da SP-DOTA-177Lu radiomarcada com baixa atividade de 177Lu foi avaliada por diferentes tempos a 2 - 8 ºC ou incubadas em soro humano a 37 ºC. A estabilidade das marcações com alta atividade de 177Lu também foi analisada na presença de ácido gentísico (6 mg/mL) adicionado após a reação de marcação. As condições de marcação em baixa e alta atividade foram submetidas à avaliação quanto à possibilidade de oxidação do resíduo de metionina, adicionando o aminoácido D-Lmetionina (6 mg/mL) ao meio de reação e posterior avaliação cromatográfica. Estudo in vitro com SP-DOTA-177Lu, radiomarcada na ausência e presença de metionina, utilizando células de glioma humano M059J e U-87 MG, verificou o efeito da oxidação da metionina sobre a ligação às células. Estudos de biodistribuição foram realizados em camundongos Nude com modelo tumoral e em camundongos Balb-c sadios. Obteve-se a maior pureza radioquímica (> 95 %) associada à maior atividade específica de SP-DOTA-177Lu quando o tempo de reação foi de 30 minutos, temperatura de 90 ºC, massa de SP-DOTA de 10 g e a atividade do 177Lu de 185 MBq. A SP radiomarcada em condições otimizadas manteve-se estável a 2 - 8 ºC e em soro humano por 4 horas. Os estudos in vitro demonstraram ligação aos receptores celulares e essa ligação mostrou-se reduzida quando o peptídeo apresenta-se em sua forma oxidada. A adição de metionina combinada com ácido gentísico preveniu a oxidação peptídica e assegurou-se a estabilidade do composto marcado, principalmente com alta atividade de 177Lu, quando se utilizou maior massa de SP-DOTA. Nos estudos in vivo,… Advisors/Committee Members: Araújo, Elaine Bortoleti de.

Subjects/Keywords: lutécio-177; lutetium-177; radiomarcação e radiofármaco; substance P; substância P

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lima, C. M. d. (2011). Estudo da marcação e biodistribuição da substância P utilizando Lutécio-177 como radiotraçador. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/85/85131/tde-05082011-102555/ ;

Chicago Manual of Style (16^th Edition):

Lima, Clarice Maria de. “Estudo da marcação e biodistribuição da substância P utilizando Lutécio-177 como radiotraçador.” 2011. Masters Thesis, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-05082011-102555/ ;.

MLA Handbook (7^th Edition):

Lima, Clarice Maria de. “Estudo da marcação e biodistribuição da substância P utilizando Lutécio-177 como radiotraçador.” 2011. Web. 27 Feb 2021.

Vancouver:

Lima CMd. Estudo da marcação e biodistribuição da substância P utilizando Lutécio-177 como radiotraçador. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-05082011-102555/ ;.

Council of Science Editors:

Lima CMd. Estudo da marcação e biodistribuição da substância P utilizando Lutécio-177 como radiotraçador. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-05082011-102555/ ;

7. Wils, Julien. Contribution à l'étude de l'effet de la substance P sur la sécrétion d'aldostérone dans la glande surrénale humaine normale : Role of substance P in the regulation of aldosterone secretion in normal human adrenal gland.

Degree: Docteur es, Aspects moleculaires et cellulaires de la biologie, 2018, Normandie

URL: http://www.theses.fr/2018NORMR011

► La sécrétion d'aldostérone par la glande surrénale est principalement contrôlée par le système rénine-angiotensine circulant (SRA) et la kaliémie. La synthèse de l'aldostérone est également… (more)

▼ La sécrétion d'aldostérone par la glande surrénale est principalement contrôlée par le système rénine-angiotensine circulant (SRA) et la kaliémie. La synthèse de l'aldostérone est également influencée par les facteurs paracrines intra-surrénaliens, y compris les neuropeptides. En particulier, les tachykinines, comme la substance P (SP), peuvent être libérées par les terminaisons nerveuses dans le cortex surrénalien. Le rôle de la SP dans la régulation de la fonction surrénalienne a été évalué chez l'animal mais rarement étudié chez l'homme. Le but de la présente étude est d'explorer le rôle de la SP dans le contrôle de la synthèse des minéralocorticoïdes dans la glande surrénale humaine. Des expériences in vitro conduites dans des échantillons surrénaliens normaux révèlent l'expression de SP codée par TAC1 qui est détecté par immunohistochimie dans des fibres nerveuses non-adrénergiques non-cholinergiques dans la zone glomérulée. Les fibres SP-positives établissent des contacts étroits avec des cellules productrices d'aldostérone qui expriment le récepteur NK1 (NK1R), récepteur de la SP. La SP stimule la production d'aldostérone à partir de cellules corticosurrénales cultivées, un effet qui est inhibé par l'aprépitant, antagoniste NK1R. L'action de la SP est relayée par la voie ERK et implique une régulation à la hausse de plusieurs gènes codant pour des enzymes de la stéroïdogénèse. Le rôle physiologique de la SP dans la régulation de la sécrétion d'aldostérone a été évalué à l'aide d'un essai clinique prospectif, contrôlé par placebo, de l'impact de l'aprépitant sur les concentrations plasmatiques et urinaires d'aldostérone chez des volontaires sains. L'aprépitant a réduit la production quotidienne d'aldostérone et la concentration plasmatique d'aldostérone (CPA) dans le décubitus, mais n'a pas modifié les CPA en position debout. Ces données montrent que la SP exerce un tonus stimulant sur la production d'aldostérone chez l'homme. p>Aldosterone secretion by the adrenal gland is principally under control of the circulating renin-angiotensin system (RAS) and kalemia. Aldosterone synthesis is also influenced by intra-adrenal paracrine factors including neuropeptides. Especially, tachykinins, like substance P (SP), can be released by nerve endings in the adrenal cortex. The role of SP in the regulation of the adrenal function has been evaluated in animals but only scarcely investigated in humans. The aim of the present study is to explore the role of SP in the control of mineralocorticoid synthesis in the human adrenal gland. In vitro experiments conducted in normal adrenal samples reveal expression of the TAC1 encoding SP which is detected by immunohistochemistry in non adrenergic non cholinergic nerve fibres in the zona glomerulosa. SP-positive fibres establish close contacts with aldosterone-producing cells which express the SP receptor, i.e. the NK1 receptor (NK1R). SP stimulates aldosterone production from cultured adrenocortical cells, an effect which is inhibited by the NK1R antagonist aprepitant. The action of…p> Advisors/Committee Members: Lefebvre, Hervé (thesis director).

Subjects/Keywords: Aldostérone; Cortex surrénalien; Substance P; Régulation paracrine; Récepteur NK1; Aprépitant; Aldosterone; Adrenal cortex; Substance P; Paracrine regulation; NK1 receptor; Agrepitant; 612.4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wils, J. (2018). Contribution à l'étude de l'effet de la substance P sur la sécrétion d'aldostérone dans la glande surrénale humaine normale : Role of substance P in the regulation of aldosterone secretion in normal human adrenal gland. (Doctoral Dissertation). Normandie. Retrieved from http://www.theses.fr/2018NORMR011

Chicago Manual of Style (16^th Edition):

Wils, Julien. “Contribution à l'étude de l'effet de la substance P sur la sécrétion d'aldostérone dans la glande surrénale humaine normale : Role of substance P in the regulation of aldosterone secretion in normal human adrenal gland.” 2018. Doctoral Dissertation, Normandie. Accessed February 27, 2021. http://www.theses.fr/2018NORMR011.

MLA Handbook (7^th Edition):

Wils, Julien. “Contribution à l'étude de l'effet de la substance P sur la sécrétion d'aldostérone dans la glande surrénale humaine normale : Role of substance P in the regulation of aldosterone secretion in normal human adrenal gland.” 2018. Web. 27 Feb 2021.

Vancouver:

Wils J. Contribution à l'étude de l'effet de la substance P sur la sécrétion d'aldostérone dans la glande surrénale humaine normale : Role of substance P in the regulation of aldosterone secretion in normal human adrenal gland. [Internet] [Doctoral dissertation]. Normandie; 2018. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2018NORMR011.

Council of Science Editors:

Wils J. Contribution à l'étude de l'effet de la substance P sur la sécrétion d'aldostérone dans la glande surrénale humaine normale : Role of substance P in the regulation of aldosterone secretion in normal human adrenal gland. [Doctoral Dissertation]. Normandie; 2018. Available from: http://www.theses.fr/2018NORMR011

8. Carvalho, Guilherme Luiz de Castro. Estudo de análogo da subtância P para desenvolvimento de radiofármaco com aplicação na terapia de tumores cerebrais.

Degree: PhD, Tecnologia Nuclear - Aplicações, 2015, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-25092015-090446/ ;

► Atualmente os gliomas representam cerca de 81% dos tumores cerebrais malignos, com aumento na incidência tanto em crianças, como em adultos acima dos 45 anos.… (more)

▼ Atualmente os gliomas representam cerca de 81% dos tumores cerebrais malignos, com aumento na incidência tanto em crianças, como em adultos acima dos 45 anos. Um número elevado de receptores neuroquinina tipo 1 (NK-1) estão expressos em células de glioma, estando a ligação da Substância P (SP) a esses receptores, envolvida no desenvolvimento e progressão desse tipo de tumor. A SP quelada ao DOTA (SP-DOTA), radiomarcada, vem sendo testada para utilização na terapia de gliomas, sendo o lutécio-177 (177Lu), devido a seu menor alcance tecidual, o radioisótopo mais indicado para tumores localizados em áreas críticas do cérebro. No entanto, estudos indicam a necessidade da adição de um excesso de metionina para prevenção da oxidação peptídica da SP-DOTA-177Lu, visando aumentar a estabilidade e a capacidade de ligação às células tumorais. Para superar esse desafio, surge a perspectiva da utilização de um novo análogo da SP, com estrutura modificada, para prevenir a oxidação peptídica. Neste contexto, o objetivo desse trabalho foi estudar a marcação de um novo análogo da SP com 177Lu e caracterizar suas propriedades in vitro e in vivo, visando a obtenção de um radiofármaco inédito e com potencial aplicação na terapia de tumores cerebrais e realizar estudos preliminares de marcação deste novo análogo com Ítrio-90 (90Y). O novo análogo foi obtido pela troca do aminoácido metionina (Met) pelo aminoácido norleucina (Nle) na posição 11 da cadeia peptídica da SP, sendo esses peptídeos denominados respectivamente SP(Met11)-DOTA e SP(Nle11)-DOTA. Após análise da oxidação peptídica dos dois peptídeos, os parâmetros da radiomarcação da SP(Nle11)-DOTA, com 177LuCl3, foram estudados para determinar a melhor condição de marcação. As estabilidades in vitro da SP(Nle11)-DOTA-177Lu sob refrigeração (2-8°C), no freezer (-20°C) e em soro humano (37°C) foram determinadas após radiomarcação com alta atividade, quanto ao uso de agentes estabilizantes e após diluição. A SP(Nle11)-DOTA também foi radiomarcada com 90Y, utilizando-se a condição padrão determinada, sendo a estabilidade in vitro da SP(Nle11)-DOTA-90Y sob refrigeração (2-8°C) e em freezer (-20°C), avaliada após radiomarcação com alta atividade e quanto a utilização de agente estabilizante. A capacidade de ligação in vitro às células tumorais (U-87 MG e M059J) e a biodistribuição in vivo em camundongos BALB/c sadios foram determinadas para a SP(Nle11)-DOTA-177Lu e comparadas à SP(Met11)-DOTA-177Lu. A ligação às proteínas plasmáticas e a biodistribuição em camundongos Nude com modelo tumoral também foram avaliadas. Os resultados obtidos na análise da oxidação peptídica comprovaram a importância da adição de excesso de metionina para prevenção da oxidação peptídica e indicaram uma alta estabilidade da SP(Nle11)-DOTA, durante e após o processo de radiomarcação. A adição de 148 MBq (4 mCi) da solução de 177LuCl3 em HCl 0,05N à 10 μg de SP(Nle11)-DOTA diluída em tampão acetato de sódio 0,4 M pH 4,5 seguida pela incubação a uma temperatura de 90ºC por 30 minutos, sob agitação de 350 rpm… Advisors/Committee Members: Araújo, Elaine Bortoleti de.

Subjects/Keywords: glioma; gliomas; lutécio-177; lutetium-177; radionuclide therapy; substance P; substância P; terapia radionuclídica

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carvalho, G. L. d. C. (2015). Estudo de análogo da subtância P para desenvolvimento de radiofármaco com aplicação na terapia de tumores cerebrais. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/85/85131/tde-25092015-090446/ ;

Chicago Manual of Style (16^th Edition):

Carvalho, Guilherme Luiz de Castro. “Estudo de análogo da subtância P para desenvolvimento de radiofármaco com aplicação na terapia de tumores cerebrais.” 2015. Doctoral Dissertation, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-25092015-090446/ ;.

MLA Handbook (7^th Edition):

Carvalho, Guilherme Luiz de Castro. “Estudo de análogo da subtância P para desenvolvimento de radiofármaco com aplicação na terapia de tumores cerebrais.” 2015. Web. 27 Feb 2021.

Vancouver:

Carvalho GLdC. Estudo de análogo da subtância P para desenvolvimento de radiofármaco com aplicação na terapia de tumores cerebrais. [Internet] [Doctoral dissertation]. University of São Paulo; 2015. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-25092015-090446/ ;.

Council of Science Editors:

Carvalho GLdC. Estudo de análogo da subtância P para desenvolvimento de radiofármaco com aplicação na terapia de tumores cerebrais. [Doctoral Dissertation]. University of São Paulo; 2015. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-25092015-090446/ ;

9. Santos, Fabio Martinez dos. Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática.

Degree: PhD, Ciências Morfofuncionais, 2015, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-05102015-150313/ ;

► A técnica de Mobilização Neural (MOB) é um método não invasivo que demonstrou tanto na pesquisa básica, como na pesquisa clinica ser eficaz na redução… (more)

▼ A técnica de Mobilização Neural (MOB) é um método não invasivo que demonstrou tanto na pesquisa básica, como na pesquisa clinica ser eficaz na redução da sensibilidade à dor. O presente, estudo visa examinar os efeitos da MOB na disfunção locomotora, na força muscular, nas alterações morfológicas no nervo isquiático e nas alterações moleculares induzida pela constrição crônica (CCI) do nervo isquiático de ratos Wistar. Para analisar a disfunção locomotora utilizamos o índice funcional do nervo Isquiático (IFC). Para analisar a força muscular, o sistema Biopac System. A ultraestrutura do nervo foi analisada pela técnica de microscopia eletrônica de transmissão e as alterações moleculares por meio de ensaios de Western blot. Ao finalizarmos os tratamentos com MOB os animais foram eutanasiados e os tecidos como, nervo isquiático, gânglios das raizes posteriores (DRG L4-L6) e Susbtância Cinzenta Periaquedutal (PAG) foram retirados. Os DRG´s foram processados pela técnica de Western Blot para a detecção da substância P (SP), receptor de potencial transitório vanilóide tipo I (TRPV1) e receptores opióides dos tipos µ (MOR), δ (DOR) e k (KOR). Com relação a PAG, analisamos somente os receptores opióides por Western Blot. Nossos resultados demonstraram uma reverção da disfunção locomotora induzida pela CCI após a MOB e aumentou 172% a força do músculo tibial anterior nos animais tratados quando comparado com os animais do grupo CCI. Nossos estudos sobre a ultraestrutura do nervo isquiático demonstraram intenso processo de degeneração Waleriana após a CCI e regeneração após a MOB. Podemos sugerir um papel importante da MOB na modulação da expressão da SP e do TRPV 1. Sobre os receptores DOR e KOR no DRG, não encontramos alterações estatísticas entre os grupos, mas observamos um aumento da expressão de MOR após a MOB. Na PAG, nós observamos uma diminuição de DOR e KOR no grupo CCI e aumento após a MOB. Por outro lado, não encontramos alterações estatíticas para o receptor MOR. Baseado nestes achados, podemos sugerir que a MOB reverte a disfunção locomotora, aumenta a força muscular, induz a regeneração do nervo isquiático, modula a SP e TRPV 1 e aumentou a expressão de MOR no DRG´s. Sugerimos ainda que, a analsegia induzida pela técnica de MOB possa ter um envolvimento também com o sistema inibitório descendente de dor resultando na inibição da transmissão do estímulo nociceptivo aferente e assim, diminuindo a dor neuropática devido influência da MOB sobre os opióides na PAG. p>Neural mobilization technique (MOB) is a noninvasive method that demonstrated to be effective in reducing pain sensitivity in both clinical and research study. The present study aims to examine the effects of MOB in locomotors dysfunction, muscle strength, morphological changes in sciatic nerve and molecular changes induced by chronic constriction (CCI) of the sciatic nerve in Wistar rats. To analyze locomotors dysfunction we used the Sciatic nerve functional index (SFI). To analyze muscle strength, was used Biopac System. The nerve…p> Advisors/Committee Members: Chacur, Marucia.

Subjects/Keywords: DRG; DRG; Fisioterapia; Opióides; Opioids; PAG; PAG; Physiotherapy; Substance P; Substância P; TRPV1; TRPV1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, F. M. d. (2015). Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42131/tde-05102015-150313/ ;

Chicago Manual of Style (16^th Edition):

Santos, Fabio Martinez dos. “Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática.” 2015. Doctoral Dissertation, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-05102015-150313/ ;.

MLA Handbook (7^th Edition):

Santos, Fabio Martinez dos. “Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática.” 2015. Web. 27 Feb 2021.

Vancouver:

Santos FMd. Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática. [Internet] [Doctoral dissertation]. University of São Paulo; 2015. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-05102015-150313/ ;.

Council of Science Editors:

Santos FMd. Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática. [Doctoral Dissertation]. University of São Paulo; 2015. Available from: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-05102015-150313/ ;

10. Débora de Carvalho. Participação dos receptores NK-1 no locus coeruleus na resposta cardiorrespiratória e termorreguladora à hipercapnia.

Degree: 2009, Universidade Federal de São Carlos

URL: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=2387

► O locus coeruleus (LC) é considerado uma região quimiorreceptora a CO2/pH em mamíferos. A substância P (SP) tem sido usada como marcador de neurônios respiratórios,… (more)

▼ O locus coeruleus (LC) é considerado uma região quimiorreceptora a CO2/pH em mamíferos. A substância P (SP) tem sido usada como marcador de neurônios respiratórios, pois possui importante função nas respostas compensatórias a hipercapnia em muitas áreas do sistema nervoso central. Neurônios e processos imunorreativos a receptores neurocinina 1 (NK-1) estão amplamente distribuídos dentro do LC. Portanto, o presente estudo teve por objetivo avaliar a participação de receptores NK-1 no LC nas respostas cardiorrespiratórias e termorreguladoras à hipercapnia. Para este fim, foi injetado o conjugado SP-Saporina (SP-SAP; 2μM) no LC de ratos Wistar para lesar neurônios que expressam esses receptores, ou IgGSAP como controle. Os animais em que as injeções atingiram o quarto ventrículo (4V) foram considerados como grupo 4V. A ventilação pulmonar (VE, pletismografia de corpo inteiro), pressão arterial média (PAM), freqüência cardíaca (FC) e temperatura corporal (Tc) foram medidas por 60 min de exposição à hipercapnia (7% CO2). Para verificar a correta localização e efetividade da lesão química realizou-se a imunohistoquímica para receptores NK-1. Além disso, imunohistoquímica para tirosina hidroxilase (TH) foi realizada para averigüar se neurônios noradrenérgicos foram lesados. A técnica de Fluoro-Jade foi também utilizada para avaliar a neurodegeneração. Observou-se a redução da imunorreatividade para receptores NK-1 (72% de lesão dos neurônios) e redução da imunorreatividade para neurônios noradrenérgicos (66% dos neurônios noradrenérgicos) sete dias após injeções de SP-SAP no LC e intensa marcação na técnica de Fluoro-Jade mostrando a efetividade da lesão. Lesões seletivas de neurônios que expressam receptores NK-1 no LC não afetaram a ventilação basal, o mesmo foi observado com os animais em que a injeção atingiu o 4V. A hipercapnia causou aumento da ventilação pulmonar 9 em todos os grupos decorrente do aumento da freqüência respiratória (fR) e volume corrente (VC). Entretanto, o tratamento com SP-SAP no LC e no 4V promoveu atenuação da resposta ventilatória (30% e 20%, respectivamente), devido à diminuição do VC. A lesão com SP-SAP no LC e no 4V não afetou a PAM, entretanto promoveu aumento na FC em ambos grupos. Os resultados sugerem que os neurônios que expressam receptores NK-1 no LC modulam a resposta ventilatória à hipercapnia, porém não possuem papel tônico na ventilação em condições basais. Além disso, esses neurônios não participam da regulação da temperatura e da PAM em normocapnia e hipercapnia, mas modulam FC durante exposição ao CO2. Essa modulação pode ser devida a alteração na liberação de noradrenalina. p>The locus coeruleus (LC) has been suggested as a CO2 chemoreceptor site in mammals. Substance P (SP) has been used as a marker of respiratory neurons and it plays an important role in compensatory responses to hypercapnia in several sites of the central nervous system. Neurokinin-1 (NK-1) receptor immunoreactive (NK1Rir) neurons and processes are widely distributed within the LC. Thus, the present…p> Advisors/Committee Members: Luciane Helena Gargaglioni Batalhão.

Subjects/Keywords: Respiração; Quimiorrecepção; Locus coeruleus; Substância P; CO2; A6; Quimiossensibilidade; FISIOLOGIA; Substance P; Chemosensitivity; Breathing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carvalho, D. d. (2009). Participação dos receptores NK-1 no locus coeruleus na resposta cardiorrespiratória e termorreguladora à hipercapnia. (Thesis). Universidade Federal de São Carlos. Retrieved from http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=2387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carvalho, Débora de. “Participação dos receptores NK-1 no locus coeruleus na resposta cardiorrespiratória e termorreguladora à hipercapnia.” 2009. Thesis, Universidade Federal de São Carlos. Accessed February 27, 2021. http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=2387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carvalho, Débora de. “Participação dos receptores NK-1 no locus coeruleus na resposta cardiorrespiratória e termorreguladora à hipercapnia.” 2009. Web. 27 Feb 2021.

Vancouver:

Carvalho Dd. Participação dos receptores NK-1 no locus coeruleus na resposta cardiorrespiratória e termorreguladora à hipercapnia. [Internet] [Thesis]. Universidade Federal de São Carlos; 2009. [cited 2021 Feb 27]. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=2387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carvalho Dd. Participação dos receptores NK-1 no locus coeruleus na resposta cardiorrespiratória e termorreguladora à hipercapnia. [Thesis]. Universidade Federal de São Carlos; 2009. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=2387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Georgiou, Stefanos. Διερεύνηση της επίδρασης της μουσικής στην αναισθησία και στην αναλγησία του σκύλου.

Degree: 2019, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/45158

► Music has been widely used in human anaesthesia, due to low cost, ease and safety. Additionally, its beneficial effect on physical and biochemical parameters, analgesia,… (more)

▼ Music has been widely used in human anaesthesia, due to low cost, ease and safety. Additionally, its beneficial effect on physical and biochemical parameters, analgesia, and minimization of adverse effects of anesthetics and analgesics, makes perioperative exposure to music an attractive complementary tool during anaesthesia.The aim of this research was to study the effect of music, provided during the perioperative period, on factors associated with anaesthesia and analgesia in dogs exposed to nociceptive stimuli under experimental and clinical conditions. In the first part, 20 Beagles were applied to identical nociceptive stimuli: 3 groups were formed, each of which consisted of the same 20 dogs. The first group listened to Chopin Music (CM), the second to Mozart Music (MM) and the third was the No-Music (NM) group. Dogs were premedicated with acepromazine (0.03 mg/kg) and butorphanol (0.1 mg/kg) intramuscularly; anaesthesia was induced with propofol and maintained with isoflurane while fentanyl (1 μg/kg) was provided intravenously as rescue analgesia. Anesthetic depth was monitored by use of the bispectral index (BIS), and autonomic nervous system responses (HR, BP, RR) were used to monitor the level of analgesia. Furthermore, measurements of Substance-P concentration in the dogs' serum were carried out in order to objectively evaluate pain during the intraoperative period. In the second part of the study, 24 female dogs, undergoing ovariohysterectomy, were divided into two groups of 12. Dogs of the first group were exposed to Mozart Music (MM), while those of the second were not exposed to any musical stimulus during the perioperative period (NM). The experimental design was almost identical to the first part. The BIS was not used, however the parameters evaluated were the same as in the first part of the study.In the first part of the study, the groups of dogs exposed to music achieved higher levels of sedation, required less propofol, isoflurane and fentanyl and exhibited less pronounced changes in BIS values (p <0.05), in relation to the group not exposed to music. In the second part of the study, the dogs of the MM group exhibited less fluctuations in arterial pressure than those the NM group (p<0.05). Finally, a statistically significant effect of time on the alterations of Substance-P concentrations was observed, regardless of exposure to music or not.Classical music provided during the perioperative period in laboratory dogs, results, when compared to dogs not exposed to music, in higher levels of sedation, lower consumption of propofol, isoflurane and fentanyl and less alterations in BIS values. Also, exposure to Mozart's music resulted in less fluctuations of substance P concentrations. However, these positive effects of classical music were apparent in light but not deeper anaesthesia in dogs subjected to ovariohysterectomy, probably due to dose-dependent suppression of auditory function caused by isoflurane. Finally, following a noxious stimulus, concentrations of substance P are immediately increased…

Subjects/Keywords: Αναισθησία; Αναλγησία; Μουσική; Ουσία P; Σκύλος; Anaesthesia; Analgesia; Bispectral index; Dog; Music; Substance - P

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Georgiou, S. (2019). Διερεύνηση της επίδρασης της μουσικής στην αναισθησία και στην αναλγησία του σκύλου. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/45158

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Georgiou, Stefanos. “Διερεύνηση της επίδρασης της μουσικής στην αναισθησία και στην αναλγησία του σκύλου.” 2019. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed February 27, 2021. http://hdl.handle.net/10442/hedi/45158.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Georgiou, Stefanos. “Διερεύνηση της επίδρασης της μουσικής στην αναισθησία και στην αναλγησία του σκύλου.” 2019. Web. 27 Feb 2021.

Vancouver:

Georgiou S. Διερεύνηση της επίδρασης της μουσικής στην αναισθησία και στην αναλγησία του σκύλου. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2019. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/45158.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Georgiou S. Διερεύνηση της επίδρασης της μουσικής στην αναισθησία και στην αναλγησία του σκύλου. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2019. Available from: http://hdl.handle.net/10442/hedi/45158

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

12. Chen, Shih-chieh. Change in substance P-induced edema in rat trachea : a digital photomicrography and 3-dimensional reconstruction study.

Degree: Master, Biological Sciences, 2005, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628105-130435

► Intravenous application of high dose of capsaicin to the rat stimulates C-fiber neurons that innervate the airways to release tachykinins that produce acute inflammation in… (more)

▼ Intravenous application of high dose of capsaicin to the rat stimulates C-fiber neurons that innervate the airways to release tachykinins that produce acute inflammation in the mucosal tissue. Large amount of extravasated plasma is retained underneath the tracheal epithelium to form edema. Substance P (SP) is the most important inflammation-producing peptide of tachykinin family. The present study was to investigate time-dependent formation and remission of edema induced by SP (3 µg/ml/kg) by the use of digital morphometric analysis of montages of tracheal cross sections. Furthermore, 3-dimensional reconstruction of serial tracheal sections was carried out to analyze the relative distribution of subepithelial edematous loci. Two edema indexes were designated for evaluation of the status of edema. Edema length ratio was the ratio of the total length of edematous loci to the circumference of a tracheal section. Edema area ratio was the ratio of the total area of edematous loci to the area of tracheal epithelium and associated edema. The degree of edematous status in the mucosa exhibited a time-dependent change. Five min after application of SP, edema length ratio and edema area ratio in the trachea were 35.80Â±1.42% and 16.28Â±2.51%, that were 7.6 and 7.9 times, respectively, the values of vehicle control group. At 1 h after SP, edema length ratio and edema area ratio declined to 16.40Â±2.46% and 8.00Â±1.60%, 2.2 and 2.8 times the values of control, but still significantly different (P < 0.05). At 24 or 72 h after SP, the values of edema were not significantly different (P > 0.05) from the control values. Three- dimensional reconstruction study showed that, in the trachea of rats 5 min after receiving SP, there were many subepithelial edematous loci, evenly distributed along the inner circumference of trachea. They were interconnected. The number of edematous loci decreased drastically by 1 h after SP. Loci of edema were rarely found 24 or 72 h after SP. The close association of edema to the tracheal epithelium suggests that the mucosal surface may be the site for elimination of edema fluid. Advisors/Committee Members: Shih-Chieh Chen (chair), Hung-Tu Huang (committee member), Jau-Cheng Liou (chair).

Subjects/Keywords: substance P; trachea; edema

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, S. (2005). Change in substance P-induced edema in rat trachea : a digital photomicrography and 3-dimensional reconstruction study. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628105-130435

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Shih-chieh. “Change in substance P-induced edema in rat trachea : a digital photomicrography and 3-dimensional reconstruction study.” 2005. Thesis, NSYSU. Accessed February 27, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628105-130435.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Shih-chieh. “Change in substance P-induced edema in rat trachea : a digital photomicrography and 3-dimensional reconstruction study.” 2005. Web. 27 Feb 2021.

Vancouver:

Chen S. Change in substance P-induced edema in rat trachea : a digital photomicrography and 3-dimensional reconstruction study. [Internet] [Thesis]. NSYSU; 2005. [cited 2021 Feb 27]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628105-130435.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen S. Change in substance P-induced edema in rat trachea : a digital photomicrography and 3-dimensional reconstruction study. [Thesis]. NSYSU; 2005. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628105-130435

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

13. Bunningen, N.M. van. Het effect van Triple P op het probleemgedrag van tieners.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/178849

► Objectives: The current study examined the effects of the Teen Triple P Level 3 intervention on parenting skills and the problem behavior of teens. Teen… (more)

Subjects/Keywords: Sociale Wetenschappen; Triple P, Teens, parenting program, prevention, substance use

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APA (6^th Edition):

Bunningen, N. M. v. (2010). Het effect van Triple P op het probleemgedrag van tieners. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/178849

Chicago Manual of Style (16^th Edition):

Bunningen, N M van. “Het effect van Triple P op het probleemgedrag van tieners.” 2010. Masters Thesis, Universiteit Utrecht. Accessed February 27, 2021. http://dspace.library.uu.nl:8080/handle/1874/178849.

MLA Handbook (7^th Edition):

Bunningen, N M van. “Het effect van Triple P op het probleemgedrag van tieners.” 2010. Web. 27 Feb 2021.

Vancouver:

Bunningen NMv. Het effect van Triple P op het probleemgedrag van tieners. [Internet] [Masters thesis]. Universiteit Utrecht; 2010. [cited 2021 Feb 27]. Available from: http://dspace.library.uu.nl:8080/handle/1874/178849.

Council of Science Editors:

Bunningen NMv. Het effect van Triple P op het probleemgedrag van tieners. [Masters Thesis]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/178849

University of Adelaide

14. Hassan, Islam Khamis Ahmed Mohamed. The role of substance P in cerebral edema associated with rat and human infarction and contusion.

Degree: 2006, University of Adelaide

URL: http://hdl.handle.net/2440/69464

► An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence… (more)

Subjects/Keywords: substance P; cerebral edema; rats

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APA (6^th Edition):

Hassan, I. K. A. M. (2006). The role of substance P in cerebral edema associated with rat and human infarction and contusion. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/69464

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hassan, Islam Khamis Ahmed Mohamed. “The role of substance P in cerebral edema associated with rat and human infarction and contusion.” 2006. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/69464.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hassan, Islam Khamis Ahmed Mohamed. “The role of substance P in cerebral edema associated with rat and human infarction and contusion.” 2006. Web. 27 Feb 2021.

Vancouver:

Hassan IKAM. The role of substance P in cerebral edema associated with rat and human infarction and contusion. [Internet] [Thesis]. University of Adelaide; 2006. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/69464.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hassan IKAM. The role of substance P in cerebral edema associated with rat and human infarction and contusion. [Thesis]. University of Adelaide; 2006. Available from: http://hdl.handle.net/2440/69464

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

15. Lewis, Kate. The role of substance P in the progression and complications of secondary brain tumours.

Degree: 2012, University of Adelaide

URL: http://hdl.handle.net/2440/82257

► Secondary brain tumours occur when cancer cells enter the circulation from their primary site and colonise the brain, previously shown to occur across the blood-brain… (more)

▼ Secondary brain tumours occur when cancer cells enter the circulation from their primary site and colonise the brain, previously shown to occur across the blood-brain barrier (BBB). Substance P (SP), a neurogenic inflammatory mediator, acting predominantly through NK1 receptors plays a role in opening the BBB and in the formation of oedema following stroke and brain trauma. It is hypothesised that SP may also promote the extravasation of tumour cells through the BBB, formation of peritumoral oedema and progression of secondary brain tumours. Walker 256 rat breast carcinoma cells obtained from the Centre for Medical Research, Tohoku University had superior tumorigenic properties compared to cells from the American Type Culture Collection, and were therefore subsequently used in two albino Wistar rat models of tumorigenesis. Firstly, internal carotid artery tumour cell injection was used to establish the effect of tumour cell extravasation across the BBB on brain albumin, endothelial barrier antigen (EBA) and SP immunoreactivity. I then determined if NK1 receptor antagonists could prevent tumour cell extravasation, by evaluating tumour incidence and volume. Secondly, a stereotaxic direct inoculation model was used to investigate the effect of NK1 receptor antagonists on brain tumour growth and peritumoral oedema, compared with dexamethasone treatment. Evan’s blue extravasation and albumin immunoreactivity were used to assess BBB permeability, and brain water content to evaluate cerebral oedema. Tumour volume, Ki67 immunoreactivity, caspase-3 immunoreactivity and tumour cell density were used as measures of tumour growth. Furthermore, cell viability and cell death assays determined if NK1 antagonists or dexamethasone treatment cause alterations in tumour cell growth in vitro. In the carotid model, SP and albumin immunoreactivity increased in the brain during the extravasation of tumour cells, and in the peritumoral area of established tumours. The invaded blood vessels lacked EBA immunoreactivity, indicating loss of BBB properties. However, NK1 antagonists administered in the first three days following tumour cell injection failed to reduce tumour incidence or volume, suggesting that extravasation may be a multifactorial process, and that NK1 receptor antagonism alone is not sufficient to prevent tumour extravasation and growth. In the direct inoculation model, NK1 receptor antagonists did not reduce peritumoral oedema or decrease tumour growth when used to treat established brain metastases. In contrast, dexamethasone, the standard treatment for peritumoral oedema, caused a reduction in brain water content and decreased tumour volume, but not tumour growth. The decrease in tumour volume with dexamethasone reflects reduced fluid content, as there was increased tumour cell density with no change in immunoreactivity to Ki67 (marker for proliferation) or caspase-3 (marker for apoptosis). Furthermore, in vitro studies showed no effect for dexamethasone on tumour cell viability. These results suggest that peritumoral… Advisors/Committee Members: Ghabriel, Mounir Nessiem (advisor), Vink, Robert (advisor), School of Medical Sciences (school).

Subjects/Keywords: brain metastases; substance P; Nk1 antagonist; dexamethasone; oedema; blood-brain barrier

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lewis, K. (2012). The role of substance P in the progression and complications of secondary brain tumours. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/82257

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lewis, Kate. “The role of substance P in the progression and complications of secondary brain tumours.” 2012. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/82257.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lewis, Kate. “The role of substance P in the progression and complications of secondary brain tumours.” 2012. Web. 27 Feb 2021.

Vancouver:

Lewis K. The role of substance P in the progression and complications of secondary brain tumours. [Internet] [Thesis]. University of Adelaide; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/82257.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lewis K. The role of substance P in the progression and complications of secondary brain tumours. [Thesis]. University of Adelaide; 2012. Available from: http://hdl.handle.net/2440/82257

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

16. Benson, Jessica. A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain .

Degree: Physiology, 2012, Queens University

URL: http://hdl.handle.net/1974/7446

► Chronic abdominal pain is a major cause of patient morbidity in inflammatory bowel diseases (IBD). A balance of pro- and anti-nociceptive factors regulating colonic dorsal… (more)

▼ Chronic abdominal pain is a major cause of patient morbidity in inflammatory bowel diseases (IBD). A balance of pro- and anti-nociceptive factors regulating colonic dorsal root ganglion (DRG) neurons, which synapse onto second order dorsal horn neurons, are known to regulate chronic pain but the mechanisms are poorly understood. This thesis examined whether neuroanatomical remodeling of DRG central nerve terminals underlies pro-nociceptive signaling and whether subsets of immune cells source the anti-nociceptive factor, β-endorphin. To examine pro-nociceptive mechanisms, acute and chronic dextran sulfate sodium (DSS) mouse models of colitis were established and substance P (SP; marker of nociceptor terminals) immunohistochemistry used to investigate changes in immunoreactivity of DRG terminals in the thoracic dorsal horn (segments T9-T13). SP immunoreactivity was increased in the dorsal horn (4 fold; P < 0.001) and central canal (P < 0.001) following chronic colitis. In contrast, SP immunoreactivity was unchanged in acute colitis. However, five weeks later SP immunoreactivity was increased both in the dorsal horn (4 fold; P < 0.01) and central canal (P < 0.001). In the cervical spinal cord, SP immunoreactivity was not increased following colitis, suggesting that changes seen in the thoracic level were specific to signaling from colonic DRG neurons. Immunoreactivity for the SP NK1 receptor on second order neurons was also examined and a significant increase in immunoreactivity was observed on post-synaptic second order cell bodies following chronic DSS. This could provide an additional mechanism for enhanced SP neurotransmission centrally. ii The source of the anti-nociceptive mediator, β-endorphin, during chronic DSS colitis was investigated using magnetic cell sorting and flow cytometry. The number of β- endorphin expressing CD4+ (2.4 fold; P < 0.05) and CD11b+ (2.6 fold; P < 0.05) cells in mice increased following chronic colitis. These findings suggest that during colitis there is a time-dependent increase of SP immunoreactivity in thoracic DRG central terminals, which could play a role in pro- nociceptive signaling in chronic inflammation. These actions may be balanced by anti- nociceptive factors such as β-endorphin which are found in subsets of immune cells.

Subjects/Keywords: Substance P ; Colon ; Nociceptor ; β-endorphin ; Chronic Inflammation ; Mouse ; Spinal Cord

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APA (6^th Edition):

Benson, J. (2012). A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Benson, Jessica. “A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain .” 2012. Thesis, Queens University. Accessed February 27, 2021. http://hdl.handle.net/1974/7446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Benson, Jessica. “A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain .” 2012. Web. 27 Feb 2021.

Vancouver:

Benson J. A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain . [Internet] [Thesis]. Queens University; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1974/7446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Benson J. A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain . [Thesis]. Queens University; 2012. Available from: http://hdl.handle.net/1974/7446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Carolina

17. Jubair, Shaiban. The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models.

Degree: MS, Biomedical Science, 2014, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/2990

► Substance P, a member of the tachykinin family, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers surround coronary vessels,… (more)

Subjects/Keywords: Medicine and Health Sciences; Hypoxia; Ischemia; Substance P; Tachykinin

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APA (6^th Edition):

Jubair, S. (2014). The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models. (Masters Thesis). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/2990

Chicago Manual of Style (16^th Edition):

Jubair, Shaiban. “The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models.” 2014. Masters Thesis, University of South Carolina. Accessed February 27, 2021. https://scholarcommons.sc.edu/etd/2990.

MLA Handbook (7^th Edition):

Jubair, Shaiban. “The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models.” 2014. Web. 27 Feb 2021.

Vancouver:

Jubair S. The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models. [Internet] [Masters thesis]. University of South Carolina; 2014. [cited 2021 Feb 27]. Available from: https://scholarcommons.sc.edu/etd/2990.

Council of Science Editors:

Jubair S. The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models. [Masters Thesis]. University of South Carolina; 2014. Available from: https://scholarcommons.sc.edu/etd/2990

University of Sydney

18. Heath, Emily May Ling. δ-opioid receptor trafficking in the striatum .

Degree: 2015, University of Sydney

URL: http://hdl.handle.net/2123/15425

► While primarily studied for its role in analgesia and reward processing, the δ-opioid receptor (DOPr) has also been shown to play an important role in… (more)

Subjects/Keywords: delta-opioid receptor; receptor trafficking; substance P; dopamine; striatum; learning

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APA (6^th Edition):

Heath, E. M. L. (2015). δ-opioid receptor trafficking in the striatum . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/15425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Heath, Emily May Ling. “δ-opioid receptor trafficking in the striatum .” 2015. Thesis, University of Sydney. Accessed February 27, 2021. http://hdl.handle.net/2123/15425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Heath, Emily May Ling. “δ-opioid receptor trafficking in the striatum .” 2015. Web. 27 Feb 2021.

Vancouver:

Heath EML. δ-opioid receptor trafficking in the striatum . [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2123/15425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Heath EML. δ-opioid receptor trafficking in the striatum . [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/15425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Souza, Alexandre Denadai. Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular.

Degree: PhD, Farmacologia, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/42/42136/tde-09022010-112603/ ;

► Nossa hipótese é de que os efeitos pró-inflamatórios iniciais da ativação do receptor ativado por protease 2 (PAR2) na articulação temporomandibular (ATM) sejam mediados por… (more)

▼ Nossa hipótese é de que os efeitos pró-inflamatórios iniciais da ativação do receptor ativado por protease 2 (PAR2) na articulação temporomandibular (ATM) sejam mediados por mecanismos neurogênicos. A análise por imunofluorescência revelou um alto grau de imunorreatividade ao PAR2 em aferentes primários trigeminais da ATM. Além do mais, a imunorreatividade ao PAR2 também foi observada na camada íntima da sinóvia, além de co-localizar com o marcador neuronal PGP9.5 e o neuropeptídeo substância P. A injeção intra-articular de agonistas PAR2 na ATM induziu um aumento dependente da dose no extravasamento plasmático, influxo de neutrófilos e indução de alodinia mecânica. O bloqueio farmacológico de receptors NK1 inibiu o aumento no extravasamento plasmático, influxo de neutrófilos e alodinia induzido pela ativação do PAR2. Em conclusão, a ativação do PAR2 é pró-inflamatório na ATM, via mecanismos neurogênicos envolvendo receptores NK1, sugerindo que o PAR2 é um importante componente da resposta imunológica inata na ATM. p>We hypothesised that the early pro-inflammatory effects of proteinase-activated receptor 2 (PAR2) activation in the temporomandibular joint (TMJ) are mediated by neurogenic mechanisms. Immunofluorescence analysis revealed a high degree of neurons expressing PAR2 in retrogradely labelled trigeminal ganglion neurons. Furthermore, PAR2 immunoreactivity was observed in the lining layer of the TMJ, co-localizing with the neuronal marker PGP9.5 and substance P-containing peripheral sensory nerve fibres. The intra-articular injection of PAR2 agonists into the TMJ triggered a dose-dependent increase in plasma extravasation, neutrophil influx and induction of mechanical allodynia. The pharmacological blockade of NK1 receptors abolished PAR2-induced plasma extravasation and inhibited neutrophil influx and mechanical allodynia. We conclude that PAR2 activation is pro-inflammatory in the TMJ, through a neurogenic mechanism involving NK1 receptors. This suggests that PAR2 is an important component of innate neuro-immune response in the TMJ.p> Advisors/Committee Members: Muscara, Marcelo Nicolas.

Subjects/Keywords: Arthritis; Articulação temporomandibular; Artrite; Carrageenan; Carragenina; Dor; Inflamação; Inflammation; Pain; Substance P; Substância P; Temporomandibular joint.

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APA (6^th Edition):

Souza, A. D. (2009). Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42136/tde-09022010-112603/ ;

Chicago Manual of Style (16^th Edition):

Souza, Alexandre Denadai. “Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular.” 2009. Doctoral Dissertation, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-09022010-112603/ ;.

MLA Handbook (7^th Edition):

Souza, Alexandre Denadai. “Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular.” 2009. Web. 27 Feb 2021.

Vancouver:

Souza AD. Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular. [Internet] [Doctoral dissertation]. University of São Paulo; 2009. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/42/42136/tde-09022010-112603/ ;.

Council of Science Editors:

Souza AD. Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular. [Doctoral Dissertation]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/42/42136/tde-09022010-112603/ ;

20. Brener, Sylvie. Expressão da substância P e de seu receptor Neuroquinina-1 em carcinomas espinocelulares de boca e sua implicação na atividade proliferativa tumoral.

Degree: PhD, Patologia Bucal, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/25/25136/tde-25032010-084600/ ;

► A substância P (SP) é um neuropeptídeo da família das taquicininas que regula numerosas funções biológicas por meio da ligação ao seu receptor altamente específico… (more)

▼ A substância P (SP) é um neuropeptídeo da família das taquicininas que regula numerosas funções biológicas por meio da ligação ao seu receptor altamente específico neuroquinina-1 (NK-1R). Este complexo SP/NK-1R está envolvido em diversos processos relacionados à oncogênese, como a mitogênese, angiogênese, migração celular e metástase. O objetivo deste trabalho foi investigar a expressão de substância P e de seu receptor NK-1 e sua correlação com o índice de proliferação celular em 73 pacientes portadores de 90 carcinomas espinocelulares de boca, diagnosticados e tratados no Hospital General e Hospital de La Princesa, Jaen, Espanha, durante o período de 1995 a 2008. Todos os tumores foram corados pela técnica imunoistoquímica da estreptavidina-biotina-peroxidase com os anticorpos anti-SP, anti-NK-1R e anti-Ki-67. As alterações celulares epiteliais das margens cirúrgicas livres de doença também foram registradas. A expressão imunoistoquímica da substância P e do seu receptor neurokinina-1 foi avaliada na membrana, no citoplasma e no núcleo das células epiteliais malignas e do epitélio da mucosa bucal adjacente ao tumor, nos linfócitos e nos vasos sanguíneos dos tumores. O índice de proliferação celular tumoral foi determinado pela expressão imunoistoquímica de Ki-67 identificada no núcleo das células neoplásicas. As correlações entre as diversas localizações da SP, de seu receptor NK-1R e do índice de proliferação tumoral determinado pelo Ki-67 foram determinadas estatísticamente utilizando-se o Crosstab, Regress e Descript de SUDAAN. A expressão de SP foi identificada no estroma de 77% dos tumores, na membrana de 71% das células malignas e no citoplasma de 81,2% dos tumores. A maioria dos tumores apresentou altas taxas de proliferação das células neoplásicas com mais de 50% das células imunopositivas para o Ki-67. Ao analisar as margens cirúrgicas livres de doença, observou-se expressão da SP, sobretudo no terço inferior e médio, tanto no núcleo, como no citoplasma e na membrana celular. A expressão concomitante de substância P e do receptor neurokinina-1 no citoplasma das células neoplásicas ocorreu mais frequentemente nas células tumorais em proliferação. Verificou-se que expressão de SP no câncer bucal ocorre juntamente com o aumento da expressão de NK-1R, sugerindo que as células neoplásicas epiteliais bucais podem utilizar esta via para tornarem-se mais susceptíveis aos estímulos mediados pela SP. A expressão de substância P nos linfócitos do infiltrado inflamatório e vasos sanguíneos intratumorais e peritumorais se associaram a tumores de menor tamanho, menor estádio clínico e com menor frequência metástase ganglionar. Concluiu-se que as células neoplásicas epiteliais bucais podem utilizar a via substância P/NK-1R para tornarem-se mais susceptíveis aos estímulos mediados pela SP, particularmente aqueles associados à proliferação celular. Além disso, a expressão epitelial, citoplasmática e nuclear da substância P é um evento precoce na carcinogênese bucal podendo ser considerado um marcador da presença e… Advisors/Committee Members: Oliveira, Denise Tostes.

Subjects/Keywords: Câncer de boca; Ki-67; Ki-67; Oral cancer; Receptor neurokinin-1; Receptor neuroquinina-1; Substance P; Substância P

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brener, S. (2009). Expressão da substância P e de seu receptor Neuroquinina-1 em carcinomas espinocelulares de boca e sua implicação na atividade proliferativa tumoral. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/25/25136/tde-25032010-084600/ ;

Chicago Manual of Style (16^th Edition):

Brener, Sylvie. “Expressão da substância P e de seu receptor Neuroquinina-1 em carcinomas espinocelulares de boca e sua implicação na atividade proliferativa tumoral.” 2009. Doctoral Dissertation, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/25/25136/tde-25032010-084600/ ;.

MLA Handbook (7^th Edition):

Brener, Sylvie. “Expressão da substância P e de seu receptor Neuroquinina-1 em carcinomas espinocelulares de boca e sua implicação na atividade proliferativa tumoral.” 2009. Web. 27 Feb 2021.

Vancouver:

Brener S. Expressão da substância P e de seu receptor Neuroquinina-1 em carcinomas espinocelulares de boca e sua implicação na atividade proliferativa tumoral. [Internet] [Doctoral dissertation]. University of São Paulo; 2009. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/25/25136/tde-25032010-084600/ ;.

Council of Science Editors:

Brener S. Expressão da substância P e de seu receptor Neuroquinina-1 em carcinomas espinocelulares de boca e sua implicação na atividade proliferativa tumoral. [Doctoral Dissertation]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/25/25136/tde-25032010-084600/ ;

21. Danigo, Aurore. Innervation cutanée et neuropathies périphériques : Cutaneous innervation and peripheral neuropathies.

Degree: Docteur es, Neurosciences, 2014, Limoges

URL: http://www.theses.fr/2014LIMO0037

► L’existence de douleurs neuropathiques et/ou de perte de la sensibilité douloureuse sont souvent le reflet d’une neuropathie sensitive affectant plus particulièrement les fibres nerveuses sensitives… (more)

▼ L’existence de douleurs neuropathiques et/ou de perte de la sensibilité douloureuse sont souvent le reflet d’une neuropathie sensitive affectant plus particulièrement les fibres nerveuses sensitives amyélinique Aδ et C, dites neuropathie des petites fibres (NPF). Ces fibres innervent, notamment, le derme et l’épiderme de la peau. Elles communiquent la sensibilité thermique et algique au système nerveux central et contribuent à l’homéostasie cutanée, entre autres, par la libération de neuropeptides en périphérie. De nombreuses pathologies sont associées à une altération de ces petites fibres dans la peau. Deux pathologies impliquant une NPF ont été étudiées au cours de ce travail : les escarres et la maladie de Charcot-Marie-Tooth type 1A. Un travail expérimental a été réalisé chez la souris pour répondre à la question suivante ; est-ce qu’une seule atteinte des fibres nociceptives, responsables de la perte de sensibilité peut entraîner un déséquilibre de l’homéostasie cutanée, responsable de l’apparition des escarres ? La mise en place d’un modèle de neuropathie sensitive fonctionnelle réversible a permis de mettre en en évidence l’implication des neuropeptides, substance P (SP) et « calcitonin gene-related peptide » (CGRP), libérés par les fibres nerveuses cutanées, dans la formation d’ulcères de pression. Un traitement préventif à la rhEPO (Recombinant Human Erythropoietin) dans ce modèle associant une neuropathie et des plaies de pression, protège la peau contre une pression ischémiante induisant une escarre par son effet neuroprotecteur sur les petites fibres cutanées. L’association CMT1A et NPF a été étudiée à partir de biopsies cutanées humaines. La quantification des fibres intraépidermiques révèle que 48% des patients CMT1A sont atteints d’une NPF. L’analyse des biopsies cutanées révèle également une altération du nombre et de la morphologie de cellules de Langerhans dans la maladie de CMT1A. L'ensemble de ces résultats confirme l'intérêt de l'étude des petites fibres dans des pathologies variées et confirme le potentiel thérapeutique neuroprotecteur de l'EPO p>The neuropathic pain and/or hypoalgesia often reflect a sensory neuropathy that affects particularly sensory, Aδ (thinly myelinated) and C (unmyelinated) nerve fibers. This kind of neuropathy is named "small fiber neuropathy" (SFN). These small fibers innervate the dermis and epidermis. C and Aδ free nerve endings respond to a variable range of stimuli including mechanical, thermal and pain stimuli. They conduct nociceptive signals to central nervous system and contribute to skin homeostasis, among others, by the release of neuropeptides in the periphery. Many diseases are associated with an alteration of these cutaneous small fibers. Two pathologies involving SFN were studied in this work: pressure ulcers and Charcot-Marie-Tooth disease Type 1A (CMT1A). Experimental studies on mice were performed to determine if impairment of nociceptive fibers could lead to an imbalance of skin homeostasis and could be involved in development of pressure ulcers,…p> Advisors/Committee Members: Magy, Laurent (thesis director), Demiot, Claire-Elise (thesis director).

Subjects/Keywords: Neuropathie des petites fibres; Substance P; Charcot-Marie-Tooth 1A; Peau; Escarre; Small fiber neuropathy; Substance P; Charcot-Marie-Tooth 1A; Skin; Pressure ulcer; Calcitonin gene-related peptide; 616.8

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Danigo, A. (2014). Innervation cutanée et neuropathies périphériques : Cutaneous innervation and peripheral neuropathies. (Doctoral Dissertation). Limoges. Retrieved from http://www.theses.fr/2014LIMO0037

Chicago Manual of Style (16^th Edition):

Danigo, Aurore. “Innervation cutanée et neuropathies périphériques : Cutaneous innervation and peripheral neuropathies.” 2014. Doctoral Dissertation, Limoges. Accessed February 27, 2021. http://www.theses.fr/2014LIMO0037.

MLA Handbook (7^th Edition):

Danigo, Aurore. “Innervation cutanée et neuropathies périphériques : Cutaneous innervation and peripheral neuropathies.” 2014. Web. 27 Feb 2021.

Vancouver:

Danigo A. Innervation cutanée et neuropathies périphériques : Cutaneous innervation and peripheral neuropathies. [Internet] [Doctoral dissertation]. Limoges; 2014. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2014LIMO0037.

Council of Science Editors:

Danigo A. Innervation cutanée et neuropathies périphériques : Cutaneous innervation and peripheral neuropathies. [Doctoral Dissertation]. Limoges; 2014. Available from: http://www.theses.fr/2014LIMO0037

Temple University

22. Fisher, Paul William. THE ROLE OF CYTOKINES AND SUBSTANCE P IN REPETITIVE LOADING-INDUCED BEHAVIORAL DECLINES AND TISSUE FIBROSIS.

Degree: PhD, 2015, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,336057

► Cell Biology p>Key clinical features of cumulative trauma disorders include pain, muscle weakness, and tissue fibrosis, although the etiology is still under investigation. Therefore, we… (more)

▼ Cell Biology p>Key clinical features of cumulative trauma disorders include pain, muscle weakness, and tissue fibrosis, although the etiology is still under investigation. Therefore, we first sought to characterize the temporal pattern of altered sensorimotor behaviors and inflammatory and fibrogenic processes occurring in forearm muscles and serum of young adult, female rats performing an operant, high repetition high force (HRHF) reaching and grasping task for 6, 12, or 18 weeks. Palmar mechanical sensitivity, cold temperature avoidance and spontaneous behavioral changes increased, while grip strength declined, in 18-week HRHF rats, compared to controls. Flexor digitorum muscles had increased MCP-1 levels after training and increased TNFα in 6-week HRHF rats. Serum had increased IL-1β, IL-10 and IP-10 after training. Yet both muscle and serum inflammation resolved by week 18. In contrast, IFNg increased at week 18 in both muscle and serum. Given the anti-fibrotic role of IFNg, and to identify a mechanism for the continued grip strength losses and behavioral sensitivities, we evaluated the fibrogenic proteins CCN2, collagen type I and TGFß-1, as well as the nociceptive/fibrogenic peptide substance P. Each increased in and around flexor digitorum muscles and extracellular matrix in the mid-forearm, and in nerves of the forepaw at 18 weeks. CCN2 was also increased in serum at week 18. At a time when inflammation had subsided, increases in fibrogenic proteins correlated with sensorimotor declines. Thus, muscle and nerve fibrosis may be critical components of chronic work-related musculoskeletal disorders. CCN2 and substance P may serve as potential targets for therapeutic intervention, and CCN2 as a serum biomarker of fibrosis progression. TGFß-1 and CCN2 are important mediators of tissue fibrosis by their stimulatory effect on extracellular matrix deposition, with CCN2 functions as a downstream mediator of TGFß-1. Substance P (SubP), a nociceptor-related neuropeptide, has also been linked to tissue fibrosis, although little work has been done to understand whether SubP directly causes fibrotic responses in tenocytes. Therefore, we sought to determine if SubP induces fibroblast proliferation and collagen production via CCN2 signaling directly or through the TGFß-1/CCN2 signaling pathway. We hypothesized that SubP may act directly through CCN2, independently from the TGFß-1/CCN2 signaling pathway, to increase fibroblast proliferation and fibrogenic and extracellular matrix protein production in vitro. To examine this question, we assayed cell proliferation and production of CCN2, TGFB1 and collagen type 1 in vitro using primary tendon fibroblasts (tenocytes) isolated from flexor digitorum tendons, and using rat dermal fibroblasts (RDF). We observed that cells isolated from flexor digitorum tendons that express proteins characteristic of tenocytes (vimentin and tenomodulin) underwent increased proliferation in a dose dependent manner after TGFß-1 treatment, but not SubP treatment, as did RDF cells. TGFß-1 treatment…p> Advisors/Committee Members: Barbe, Mary F., Popoff, Steven N.;, Litvin, Judith, Rico, Mario C., Rizzo, Victor;.

Subjects/Keywords: Cellular biology; Behavioral sciences; Biomechanics;

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APA (6^th Edition):

Fisher, P. W. (2015). THE ROLE OF CYTOKINES AND SUBSTANCE P IN REPETITIVE LOADING-INDUCED BEHAVIORAL DECLINES AND TISSUE FIBROSIS. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,336057

Chicago Manual of Style (16^th Edition):

Fisher, Paul William. “THE ROLE OF CYTOKINES AND SUBSTANCE P IN REPETITIVE LOADING-INDUCED BEHAVIORAL DECLINES AND TISSUE FIBROSIS.” 2015. Doctoral Dissertation, Temple University. Accessed February 27, 2021. http://digital.library.temple.edu/u?/p245801coll10,336057.

MLA Handbook (7^th Edition):

Fisher, Paul William. “THE ROLE OF CYTOKINES AND SUBSTANCE P IN REPETITIVE LOADING-INDUCED BEHAVIORAL DECLINES AND TISSUE FIBROSIS.” 2015. Web. 27 Feb 2021.

Vancouver:

Fisher PW. THE ROLE OF CYTOKINES AND SUBSTANCE P IN REPETITIVE LOADING-INDUCED BEHAVIORAL DECLINES AND TISSUE FIBROSIS. [Internet] [Doctoral dissertation]. Temple University; 2015. [cited 2021 Feb 27]. Available from: http://digital.library.temple.edu/u?/p245801coll10,336057.

Council of Science Editors:

Fisher PW. THE ROLE OF CYTOKINES AND SUBSTANCE P IN REPETITIVE LOADING-INDUCED BEHAVIORAL DECLINES AND TISSUE FIBROSIS. [Doctoral Dissertation]. Temple University; 2015. Available from: http://digital.library.temple.edu/u?/p245801coll10,336057

23. Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, Toshikazu. Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.

Degree: 博士(医学), 2017, University of Miyazaki / 宮崎大学

URL: http://hdl.handle.net/10458/6029

► 学位論文の一部を構成しているため、http://hdl.handle.net/10458/6028に本文を掲載。 p>Objective: A new mammalian tachykinin peptide encoded in a TAC4 gene was identified and designated as hemokinin-1 (HK-1). A representative of the tachykinin peptide… (more)

Subjects/Keywords: Hemokinin-1; Immunohistochemistry; Trigeminal sensory nuclear complex; Trigeminal ganglion; Pruritus; Substance P

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APA (6^th Edition):

Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, T. (2017). Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. (Thesis). University of Miyazaki / 宮崎大学. Retrieved from http://hdl.handle.net/10458/6029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, Toshikazu. “Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.” 2017. Thesis, University of Miyazaki / 宮崎大学. Accessed February 27, 2021. http://hdl.handle.net/10458/6029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori, Toshikazu. “Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.” 2017. Web. 27 Feb 2021.

Vancouver:

Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori T. Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. [Internet] [Thesis]. University of Miyazaki / 宮崎大学; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10458/6029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Igawa, Kaori; Funahashi, Hideki; Miyahara, Yu; Naono-Nakayama, Rumi; Matsuo, Hisae; Yamashita, Yoshihiro; Sakoda, Sumio; Nishimori T. Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex. [Thesis]. University of Miyazaki / 宮崎大学; 2017. Available from: http://hdl.handle.net/10458/6029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

24. Zhu, Yong Fang. ELECTROPHYSIOLOGICAL, IMMUNOHISTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON AN ANIMAL MODEL OF PERIPHERAL NEUROPATHY INDICATE A PROMINENT ROLE OF Aβ SENSORY NEURONS IN NEUROPATHIC PAIN.

Degree: PhD, 2011, McMaster University

URL: http://hdl.handle.net/11375/9343

► Based on the concept that the tactile hypersensitivity and the central sensitization observed in animal models of peripheral neuropathy are maintained by peripheral drive… (more)

Subjects/Keywords: neuropathic pain; sensory neuron; substance P; muscle spindle; pregabalin; Medical Sciences; Medical Sciences

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APA (6^th Edition):

Zhu, Y. F. (2011). ELECTROPHYSIOLOGICAL, IMMUNOHISTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON AN ANIMAL MODEL OF PERIPHERAL NEUROPATHY INDICATE A PROMINENT ROLE OF Aβ SENSORY NEURONS IN NEUROPATHIC PAIN. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/9343

Chicago Manual of Style (16^th Edition):

Zhu, Yong Fang. “ELECTROPHYSIOLOGICAL, IMMUNOHISTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON AN ANIMAL MODEL OF PERIPHERAL NEUROPATHY INDICATE A PROMINENT ROLE OF Aβ SENSORY NEURONS IN NEUROPATHIC PAIN.” 2011. Doctoral Dissertation, McMaster University. Accessed February 27, 2021. http://hdl.handle.net/11375/9343.

MLA Handbook (7^th Edition):

Zhu, Yong Fang. “ELECTROPHYSIOLOGICAL, IMMUNOHISTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON AN ANIMAL MODEL OF PERIPHERAL NEUROPATHY INDICATE A PROMINENT ROLE OF Aβ SENSORY NEURONS IN NEUROPATHIC PAIN.” 2011. Web. 27 Feb 2021.

Vancouver:

Zhu YF. ELECTROPHYSIOLOGICAL, IMMUNOHISTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON AN ANIMAL MODEL OF PERIPHERAL NEUROPATHY INDICATE A PROMINENT ROLE OF Aβ SENSORY NEURONS IN NEUROPATHIC PAIN. [Internet] [Doctoral dissertation]. McMaster University; 2011. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11375/9343.

Council of Science Editors:

Zhu YF. ELECTROPHYSIOLOGICAL, IMMUNOHISTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON AN ANIMAL MODEL OF PERIPHERAL NEUROPATHY INDICATE A PROMINENT ROLE OF Aβ SENSORY NEURONS IN NEUROPATHIC PAIN. [Doctoral Dissertation]. McMaster University; 2011. Available from: http://hdl.handle.net/11375/9343

Université de Montréal

25. Touzin, Karine. Le rôle des kinines, de la substance P et du récepteur B₁ dans la physiopathologie de l'angiooedème acquis : Approche expérimentale et clinique.

Degree: 2007, Université de Montréal

URL: http://hdl.handle.net/1866/15665

Subjects/Keywords: Angiooedème; Kinines; Métabolisme; Métallopeptidases; Substance P

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APA (6^th Edition):

Touzin, K. (2007). Le rôle des kinines, de la substance P et du récepteur B₁ dans la physiopathologie de l'angiooedème acquis : Approche expérimentale et clinique. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/15665

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Touzin, Karine. “Le rôle des kinines, de la substance P et du récepteur B₁ dans la physiopathologie de l'angiooedème acquis : Approche expérimentale et clinique.” 2007. Thesis, Université de Montréal. Accessed February 27, 2021. http://hdl.handle.net/1866/15665.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Touzin, Karine. “Le rôle des kinines, de la substance P et du récepteur B₁ dans la physiopathologie de l'angiooedème acquis : Approche expérimentale et clinique.” 2007. Web. 27 Feb 2021.

Vancouver:

Touzin K. Le rôle des kinines, de la substance P et du récepteur B₁ dans la physiopathologie de l'angiooedème acquis : Approche expérimentale et clinique. [Internet] [Thesis]. Université de Montréal; 2007. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1866/15665.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Touzin K. Le rôle des kinines, de la substance P et du récepteur B₁ dans la physiopathologie de l'angiooedème acquis : Approche expérimentale et clinique. [Thesis]. Université de Montréal; 2007. Available from: http://hdl.handle.net/1866/15665

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

26. Barry, Christine. Characterising the role of the neuropeptide substance P in experimental subarachnoid haemorrhage.

Degree: 2011, University of Adelaide

URL: http://hdl.handle.net/2440/70730

► Background: Raised intracranial pressure (ICP) following SAH predicts poor outcome and is due to hemorrhage volume and possibly brain oedema, hydrocephalus and increased volume of… (more)

▼ Background: Raised intracranial pressure (ICP) following SAH predicts poor outcome and is due to hemorrhage volume and possibly brain oedema, hydrocephalus and increased volume of circulating intracranial blood. Interventions that reduce oedema may therefore reduce ICP and improve outcome. The neuropeptide substance P (SP) mediates vasogenic oedema formation in animal models of ischemic stroke, intracerebral hemorrhage and brain trauma, and may contribute to the development of increased ICP. Blockade of the SP NK1 tachykinin receptor using n-acetyl-l-tryptophan (NAT) reduces brain oedema and improves outcome in these models. This intervention had not previously been tested in models of SAH. This study therefore assessed whether SP mediates oedema formation in experimental SAH, and whether NAT treatment impacted on ICP and functional outcome. Methods: SAH was induced in adult male Sprague-Dawley rats by either injection of autologous blood into the prechiasmatic cistern (injection SAH) or by endovascular arterial puncture of the Circle of Willis (filament SAH). NAT was injected (i.v.) at 30 minutes after induction of SAH. Subgroups were assessed for brain water content, immunoreactivity to SP, albumin immunoreactivity and functional outcome at 5, 24 and 48 hours, or ICP and cerebral perfusion pressure during SAH and over the following 5 hours. Results: In both models a primary ICP increase occurred during SAH and a secondary ICP increase occurred within 2 hours. Injection SAH was followed by a non-significant increase in brain water content and caused no functional deficits. In contrast, brain oedema followed filament SAH (p < 0.001) and correlated with functional deficits (r = 0.8, p < 0.01). Increased albumin immunoreactivity (p < 0.001) indicated vasogenic brain oedema. Cerebral perfusion pressure was diminished after filament SAH and some animals demonstrated plateau waves of ICP. NAT treatment did not improve ICP, oedema or outcome. Conclusion: SAH produced secondary ICP elevation, vasogenic brain oedema and functional deficits, but it is unclear if oedema contributed to ICP. Blockade of SP did not improve any outcome parameters, suggesting that SP-mediated neurogenic inflammation may be less critical to outcome than other factors in these models. Advisors/Committee Members: Vink, Robert (advisor), Van Den Heuvel, Corinna (advisor), School of Medical Sciences (school).

Subjects/Keywords: subarachnoid haemorrhage; intracranial pressure; brain oedema; cerebral perfusion pressure; substance P; neurological outcome

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APA (6^th Edition):

Barry, C. (2011). Characterising the role of the neuropeptide substance P in experimental subarachnoid haemorrhage. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/70730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Barry, Christine. “Characterising the role of the neuropeptide substance P in experimental subarachnoid haemorrhage.” 2011. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/70730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Barry, Christine. “Characterising the role of the neuropeptide substance P in experimental subarachnoid haemorrhage.” 2011. Web. 27 Feb 2021.

Vancouver:

Barry C. Characterising the role of the neuropeptide substance P in experimental subarachnoid haemorrhage. [Internet] [Thesis]. University of Adelaide; 2011. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/70730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barry C. Characterising the role of the neuropeptide substance P in experimental subarachnoid haemorrhage. [Thesis]. University of Adelaide; 2011. Available from: http://hdl.handle.net/2440/70730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

27. Harford-Wright, Elizabeth Asha. Characterising the role of substance P in human and experimental brain tumours.

Degree: 2013, University of Adelaide

URL: http://hdl.handle.net/2440/90753

► Currently within Australia, brain tumours account for one death every eight hours. They are inherently difficult to treat, and even with the best current treatments,… (more)

▼ Currently within Australia, brain tumours account for one death every eight hours. They are inherently difficult to treat, and even with the best current treatments, prognosis for these patients remains extremely poor. At present, treatment options for patients with either primary or secondary brain tumours are limited. Indeed most brain metastasis patients have a short survival time, despite the fact that initial treatment is often effective in reducing neurological deficits and tumour size. One of the most serious complications of brain tumours is cerebral oedema, which is typically vasogenic in nature due to disruption of normal blood brain barrier function. Cerebral oedema is associated with many life-threatening complications such as raised intracranial pressure, reduction in cerebral perfusion pressure and in severe cases can result in brain herniation and death. Although treatments for cerebral oedema currently exist, they are associated with many deleterious side effects, prompting the search for alternative treatments. The neuropeptide substance P and its NK1 receptor are reported to be upregulated in a number of different cancer types. This increase is thought to correspond with SP mediated increases in cellular proliferation, impairment of apoptosis and increased angiogenesis. Furthermore, SP has recently been implicated in the development of neurogenic inflammation in the brain, where it is associated with vasodilation, plasma extravasation and genesis of oedema. Accordingly, the current thesis sought to determine whether SP may provide a novel treatment target in both tumour associated oedema and tumour growth. Immunohistochemical assessment of human primary and secondary brain tumour tissue demonstrated a marked increase in SP and the NK1 receptor in all tumour types investigated, confirming what has been previously observed in the literature. Of the mestastatic tumours, melanoma demonstrated particularly elevated levels of SP and its receptor. Correspondingly, a human melanoma cell line, A-375, was examined in vitro and found to express both SP and the NK1 receptor. Furthermore, treatment with NK1 antagonists resulted in decreased cell viability of A-375 melanoma cells and an increase in cell death in this cell line in vitro, implicating SP in the facilitation of tumour growth. An in vivo model of brain tumours using the same cell line, demonstrated increased SP and the NK1 receptor not only within the tumour, but also in peritumoural vessels. This increase corresponded with a significant increase in brain water content and BBB permeability, implicating SP in the genesis of tumour associated oedema. Subsequent administration of the NK1 antagonist, Emend decreased BBB dysfunction and oedema formation and was more efficacious than the current clinical treatment choice, dexamethasone. Furthermore, treatment with Emend resulted in a decrease in tumour volume and in the number of proliferating cells, as well as an increase in apoptotic cells, an effect that was not seen with dexamethasone treatment. This… Advisors/Committee Members: Vink, Robert (advisor), Ghabriel, Mounir Nessiem (advisor), School of Medical Sciences (school).

Subjects/Keywords: substance P; brain tumours; cancer growth; oedema; blood brain barrier; NK1 receptor antagonists

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Harford-Wright, E. A. (2013). Characterising the role of substance P in human and experimental brain tumours. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/90753

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Harford-Wright, Elizabeth Asha. “Characterising the role of substance P in human and experimental brain tumours.” 2013. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/90753.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Harford-Wright, Elizabeth Asha. “Characterising the role of substance P in human and experimental brain tumours.” 2013. Web. 27 Feb 2021.

Vancouver:

Harford-Wright EA. Characterising the role of substance P in human and experimental brain tumours. [Internet] [Thesis]. University of Adelaide; 2013. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/90753.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Harford-Wright EA. Characterising the role of substance P in human and experimental brain tumours. [Thesis]. University of Adelaide; 2013. Available from: http://hdl.handle.net/2440/90753

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

28. Donkin, James J. The effects of the neuropeptide substance P on outcome following experimental traumatic brain injury in rats.

Degree: 2006, University of Adelaide

URL: http://hdl.handle.net/2440/37854

► Traumatic brain injury (TBI) today remains a major health and social problem for both developed and developing countries. It is the leading cause of death… (more)

▼ Traumatic brain injury (TBI) today remains a major health and social problem for both developed and developing countries. It is the leading cause of death and disability under the age of 40, and despite the significance of this public health problem, no effective therapy exists. While a number of factors have been shown to be associated with the development of irreversible tissue injury after TBI, the formation of oedema and opening of the blood brain barrier (BBB) have been shown to be of major significance to outcome. Oedema formation in the brain, when left uncontrolled, results in increased intracranial pressure that may lead to a decrease in brain tissue perfusion, localised hypoxia and ischemia, and ultimately tissue herniation and death. The mechanisms associated with the development of oedema are largely unclear, and accordingly, current therapies are generally ineffective, often resulting in dehydration, hypotension and renal problems. This thesis describes the characterisation of neurogenic inflammation in the development of post-traumatic brain oedema and functional deficits, and particularly the role of substance P (SP) in mediating their development, using rodent models of both focal and diffuse TBI. Results from this thesis demonstrate that increased SP immunoreactivity, particularly at the level of the vasculature, is a ubiquitous feature of TBI implying a potential role in the breakdown of the blood brain barrier (BBB) following TBI. This was confirmed through the use of the NK[subscript 1] receptor antagonists, which attenuated BBB and oedema formation as well as deleterious morphological events such as dark cell change and axonal injury. The NK[subscript 1] receptor antagonists also resulted in an associated improvement in both motor and cognitive deficits, as assessed using a battery of functional outcome tests. Possible mechanisms of action of the NK[subscript 1] receptor antagonist included effects on the BBB, SP release, intracellular free magnesium concentration and aquaporin-4 channels. Neuroprotection could be facilitated with administration of a non-lipid permeable NK[subscript 1] receptor antagonist in the immediate postinjury period, or up to 12 h after TBI with a lipid permeable NK[subscript 1] receptor antagonist, suggesting that this class of drugs have a clinically viable therapeutic window. We conclude that SP has a significant role in the secondary injury process following TBI and may offer a novel target for the development of interventional pharmacological strategies. Advisors/Committee Members: Vink, Robert (advisor), Heuval, Corinna Van Den (advisor), School of Medical Sciences (school).

Subjects/Keywords: brain damage; substance P; inflammation; neuropeptides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Donkin, J. J. (2006). The effects of the neuropeptide substance P on outcome following experimental traumatic brain injury in rats. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/37854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Donkin, James J. “The effects of the neuropeptide substance P on outcome following experimental traumatic brain injury in rats.” 2006. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/37854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Donkin, James J. “The effects of the neuropeptide substance P on outcome following experimental traumatic brain injury in rats.” 2006. Web. 27 Feb 2021.

Vancouver:

Donkin JJ. The effects of the neuropeptide substance P on outcome following experimental traumatic brain injury in rats. [Internet] [Thesis]. University of Adelaide; 2006. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/37854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Donkin JJ. The effects of the neuropeptide substance P on outcome following experimental traumatic brain injury in rats. [Thesis]. University of Adelaide; 2006. Available from: http://hdl.handle.net/2440/37854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

29. Petrović, Romana Lj., 1974-. Morfološke i biohemijske promene u prefrontalnom korteksu, amigdaloidnom telu i hipokampalnoj formaciji mozga pacova uslovljene pojedinačnim produženim stresom.

Degree: Medicinski fakultet, 2019, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:19388/bdef:Content/get

► Medicina - Neuronauke / Medicine - Neuroscience p>Posttraumatski stresni poremećaj (PTSP) je veoma rasprostranjeno i onesposobljavajuće oboljenje. Uprkos raspoloživoj psihofarmakološkoj i na dokazima zasnovanoj kognitivno-bihejvioralnoj… (more)

▼ Medicina - Neuronauke / Medicine - Neuroscience p>Posttraumatski stresni poremećaj (PTSP) je veoma rasprostranjeno i onesposobljavajuće oboljenje. Uprkos raspoloživoj psihofarmakološkoj i na dokazima zasnovanoj kognitivno-bihejvioralnoj terapiji, kod značajnog broja PTSP pacijenata nema odgovora na konvencionalnu terapiju, što pokazuje da su patogenetski mehanizmi u PTSP-u još uvek nedovoljno ispitani. Pojedinačni produženi stres (PPS) predstavlja koristan animalni model PTSP-a za razumevanje patofiziologije oboljenja i razvoj novih terapijskih strategija. Preovlađujući neuroanatomski model PTSP-a, naglašava centralni značaj amigdale kao i njene interakcije sa medijalnim prefrontalnim korteksom i hipokampusom. Mnoge studije pokazuju da su neuropatološke i psihološke alteracije kod PTSD pacijenata povezane sa oksidativnim stresom u mozgu. Glavni izvori slobodnih radikala u ćeliji su mitohondrijalni respiratorni lanac i sistem nikotinin adenin dinukleotid fosfat (NADPH) fosfataze. Ekscitatorno/inhibitorni disbalans zbog disfunkcionalne GABA-ergičke neuronske mreže, ima patofiziološki značaj u mnogim psihijatrijskim oboljenjima. Parvalbumin inhibitorni interneuroni su veoma značajni za održavanje odgovarajuće ekscitatorno/inhibitorne ravnoteže i u sinhronizaciji visokofrekventnog neuronskog pražnjenja i mogu biti uključeni u patološko učenje straha u PTSP-u. Takođe, mnoge studije su pokazale učešće različitih neuropeptida u procesiranju stresnih stimulusa i stresnom odgovoru. Cilj: Cilj ove disertacije se sastojao u ispitivanju uticaja pojedinačnog produženog stresa na: (1) parametre oksidativnog stresa uključujući nivo malondialdehida (MDA), sadržaj redukovanog glutationa (GSH), aktivnost glutation peroksidaze (GPx), superoksid dizmutaze (SOD) i katalaze (CAT), i ekspresiju SOD1 i SOD2; (2) moguće generatore slobodnih radikala: mitohondrijalni respiratorni lanac, određivanjem aktivnosti kompleksa I i citohrom c oksidaze (COX) i NADPH oksidazu, određivanjem ekspresije membranskih (gp91phox i p22phox) i citosolnih (p67phox) subjedinica ovog enzima i (3) ukupan broj neurona (NeuN pozitivne ćelije), broj parvalbumin (PV) i kalbindin (CB) pozitivnih GABA-ergičkih neurona i broj supstanca P (SP), enkefalin (ENK) i galanin (GAL) pozitivnih peptidergičkih neurona u prefrontalnom korteksu (PFK), hipokampusu i amigdali mozga pacova...p> Advisors/Committee Members: Petronijević, Nataša, 1963-.

Subjects/Keywords: single prolonged stress; post-traumatic stress; amygdala; NADPH oxidase; substance P; galanin; enkephaline

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Petrović, Romana Lj., 1. (2019). Morfološke i biohemijske promene u prefrontalnom korteksu, amigdaloidnom telu i hipokampalnoj formaciji mozga pacova uslovljene pojedinačnim produženim stresom. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:19388/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Petrović, Romana Lj., 1974-. “Morfološke i biohemijske promene u prefrontalnom korteksu, amigdaloidnom telu i hipokampalnoj formaciji mozga pacova uslovljene pojedinačnim produženim stresom.” 2019. Thesis, Univerzitet u Beogradu. Accessed February 27, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:19388/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Petrović, Romana Lj., 1974-. “Morfološke i biohemijske promene u prefrontalnom korteksu, amigdaloidnom telu i hipokampalnoj formaciji mozga pacova uslovljene pojedinačnim produženim stresom.” 2019. Web. 27 Feb 2021.

Vancouver:

Petrović, Romana Lj. 1. Morfološke i biohemijske promene u prefrontalnom korteksu, amigdaloidnom telu i hipokampalnoj formaciji mozga pacova uslovljene pojedinačnim produženim stresom. [Internet] [Thesis]. Univerzitet u Beogradu; 2019. [cited 2021 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:19388/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Petrović, Romana Lj. 1. Morfološke i biohemijske promene u prefrontalnom korteksu, amigdaloidnom telu i hipokampalnoj formaciji mozga pacova uslovljene pojedinačnim produženim stresom. [Thesis]. Univerzitet u Beogradu; 2019. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:19388/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Sherbrooke

30. Normandin, Audrey. Visualisation du récepteur opioïdergique delta et implication des récepteurs opioïdergiques mu et delta dans le contrôle des douleurs thermiques et mécaniques.

Degree: 2013, Université de Sherbrooke

URL: http://hdl.handle.net/11143/6347

► Les principaux analgésiques utilisés en clinique ciblent majoritairement le récepteur opioïdergique mu (MOPR). Or, l'activation de MOPR engendre d'importants effets secondaires. Les agonistes sélectifs au… (more)

▼ Les principaux analgésiques utilisés en clinique ciblent majoritairement le récepteur opioïdergique mu (MOPR). Or, l'activation de MOPR engendre d'importants effets secondaires. Les agonistes sélectifs au récepteur opioïdergique delta (DOPR) représentent une cible thérapeutique intéressante, puisqu'ils engendrent moins d'effets secondaires comparativement à l'activation du récepteur opioïdergique mu (MOPR). Dans la littérature, 2 hypothèses s'opposent concernant à la fois la distribution de DOPR et de MOPR au sein des sous-populations neuronales ainsi que leur implication fonctionnelle dans certaines modalités de douleurs. D'une part, des études, dont certaines basées sur l'utilisation d'anticorps, ont suggéré une colocalisation de ces 2 récepteurs au sein des mêmes sous-populations neuronales. Cette colocalisation suggère que l'activation de MOPR ou DOPR soulage les mêmes modalités de douleurs. D'autre part, une étude a remis en doute la spécificité des anticorps commerciaux ciblant DOPR, remettant ainsi en question les travaux réalisés avec cet outil. Par ailleurs, les auteurs de cette même étude ont aussi observé une ségrégation physique et fonctionnelle entre DOPR et MOPR : non seulement DOPR et MOPR seraient exprimés par des populations neuronales différentes, mais DOPR régulerait préférentiellement les douleurs d'origine mécanique, alors que MOPR serait plutôt impliqué dans le soulagement des douleurs d'origine thermique. Afin de répondre à cette controverse, il a d'abord été nécessaire de trouver un outil alternatif à l'utilisation des anticorps ciblant DOPR. Idéalement, cet outil doit permettre la visualisation de la distribution de ce récepteur autant au niveau de cellules en culture que des tissus. Pour ce faire, les propriétés pharmacologiques de 2 ligands biotinylés, le TIPP-biotine (Tyr-Tic-Phe-Phe(para-bromoacétamide)-Asp-desthiobiotine) et la deltorphine-biotine, ont été déterminées. Les résultats obtenus ont démontré que le TIPP-biotine possède des caractéristiques de liaison sur DOPR fort intéressantes autant sur des extraits cellulaires que sur du tissu animal, alors que la deltorphine-biotine nécessite encore des modifications afin d'optimiser ses propriétés de liaison à DOPR. Dans un second temps, à l'aide d'études d'électrophysiologie unitaire extracellulaire in vivo et d'immunohistochimies du récepteur NK? (récepteur de la substance P), l'implication de MOPR dans le soulagement des douleurs thermiques et mécaniques, et celle de DOPR dans le soulagement des douleurs mécaniques ont été mises en évidence. [symboles non conformes] Advisors/Committee Members: Gendron, Louis (advisor).

Subjects/Keywords: Marqueurs d'affinité; Substance P; Afférences primaires; Interaction; Récepteur opioïdergique mu; Récepteur opioïdergique delta; Analgésie; Douleur

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Normandin, A. (2013). Visualisation du récepteur opioïdergique delta et implication des récepteurs opioïdergiques mu et delta dans le contrôle des douleurs thermiques et mécaniques. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/6347

Chicago Manual of Style (16^th Edition):

Normandin, Audrey. “Visualisation du récepteur opioïdergique delta et implication des récepteurs opioïdergiques mu et delta dans le contrôle des douleurs thermiques et mécaniques.” 2013. Masters Thesis, Université de Sherbrooke. Accessed February 27, 2021. http://hdl.handle.net/11143/6347.

MLA Handbook (7^th Edition):

Normandin, Audrey. “Visualisation du récepteur opioïdergique delta et implication des récepteurs opioïdergiques mu et delta dans le contrôle des douleurs thermiques et mécaniques.” 2013. Web. 27 Feb 2021.

Vancouver:

Normandin A. Visualisation du récepteur opioïdergique delta et implication des récepteurs opioïdergiques mu et delta dans le contrôle des douleurs thermiques et mécaniques. [Internet] [Masters thesis]. Université de Sherbrooke; 2013. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11143/6347.

Council of Science Editors:

Normandin A. Visualisation du récepteur opioïdergique delta et implication des récepteurs opioïdergiques mu et delta dans le contrôle des douleurs thermiques et mécaniques. [Masters Thesis]. Université de Sherbrooke; 2013. Available from: http://hdl.handle.net/11143/6347

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Open Access Theses and Dissertations