subject:(Stents Surgery )

1. Karman, Kristen. 2-D CFD design of the cross-sectional shape of arterial stents.

Degree: 2013, University of Tennessee – Chattanooga

► An approach for desigining arterial stents to maximize wall shear stress is presented. A cost equation to maximize wall shear stress is derived and then… (more)

Subjects/Keywords: Stents (Surgery); Stents (Surgery) – Fluid dynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karman, K. (2013). 2-D CFD design of the cross-sectional shape of arterial stents. (Masters Thesis). University of Tennessee – Chattanooga. Retrieved from https://scholar.utc.edu/theses/97

Chicago Manual of Style (16^th Edition):

Karman, Kristen. “2-D CFD design of the cross-sectional shape of arterial stents.” 2013. Masters Thesis, University of Tennessee – Chattanooga. Accessed March 01, 2021. https://scholar.utc.edu/theses/97.

MLA Handbook (7^th Edition):

Karman, Kristen. “2-D CFD design of the cross-sectional shape of arterial stents.” 2013. Web. 01 Mar 2021.

Vancouver:

Karman K. 2-D CFD design of the cross-sectional shape of arterial stents. [Internet] [Masters thesis]. University of Tennessee – Chattanooga; 2013. [cited 2021 Mar 01]. Available from: https://scholar.utc.edu/theses/97.

Council of Science Editors:

Karman K. 2-D CFD design of the cross-sectional shape of arterial stents. [Masters Thesis]. University of Tennessee – Chattanooga; 2013. Available from: https://scholar.utc.edu/theses/97

Rutgers University

2. Chan, Jennifer Wing-Yee. Design, fabrication, and characterization of bioactive amphiphilic polymers as cardiovascular therapeutics.

Degree: PhD, Biomedical Engineering, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49920/

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Recent advancements in cardiovascular drug-eluting stents (DES) have significantly improved clinical outcomes and survival rates in patients with arteries blocked by fat and cholesterol accumulation.… (more)

▼

Recent advancements in cardiovascular drug-eluting stents (DES) have significantly improved clinical outcomes and survival rates in patients with arteries blocked by fat and cholesterol accumulation. Current DES utilize a cytotoxic or immunosuppressive agent to overcome earlier issues of restenosis, or smooth muscle cell (SMC) hyperproliferation, but the drugs and polymer overcoat are associated with an increased risk of late-stent thrombosis, or blood clot formation due to delayed re-endothelialization and hypersensitivity reactions. Both of these issues restrict blood flow and may cause angina, myocardial infarction, and/or death. An alternative therapeutic strategy is to target upstream events in the restenosis and thrombosis cascades, such as high levels of oxidative stress. In this research, bioactive micelles and nanoparticles were developed to minimize cellular interactions of oxidized low-density lipoprotein (oxLDL), which has been shown to induce excessive cellular proliferation and platelet activation. These formulations are comprised of amphiphilic macromolecules (AMs) containing a sugar-based hydrophobic domain and a hydrophilic poly(ethylene glycol) tail. The results indicate that when SMCs are exposed to high levels of oxidized lipid stimuli, AM nanoassemblies inhibited oxLDL uptake, downregulated scavenger receptor expression, and attenuated scavenger receptor gene transcription, and thus significantly suppressed SMC proliferation with minimal cytotoxicity. The potential for bioactive AM delivery was further evaluated as stent coatings, where AMs were self-assembled into monolayer coatings on metal oxide substrates using grafting-from and grafting-to approaches. In the grafting-from technique, molecules were polymerized from the surface in a multi-step synthesis, whereas polymers were pre-synthesized before end-functionalization to the surface in the grafting-to method. Densely packed layers of bioactive AMs gradually released from substrates, significantly suppressing SMC proliferation and platelet adsorption. Variations in the grafting method, functional end group, and linker length yielded a range of AM grafting densities, release rates, and reductions in SMC proliferation and platelet adsorption, suggesting that the bioactive AM release profile can be tuned to match physiological events in the restenosis and thrombosis cascades. Overall, the findings in this thesis highlight the potential of using AM formulations as stand-alone bioactive agents or for controlled therapeutic delivery from coronary stents to minimize restenosis and thrombosis.

Advisors/Committee Members: Uhrich, Kathryn E. (chair), Fabris, Laura (internal member), Roth, Charles M. (internal member), Eknoian, Michael W. (outside member).

Subjects/Keywords: Stents (Surgery); Macromolecules

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chan, J. W. (2016). Design, fabrication, and characterization of bioactive amphiphilic polymers as cardiovascular therapeutics. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49920/

Chicago Manual of Style (16^th Edition):

Chan, Jennifer Wing-Yee. “Design, fabrication, and characterization of bioactive amphiphilic polymers as cardiovascular therapeutics.” 2016. Doctoral Dissertation, Rutgers University. Accessed March 01, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49920/.

MLA Handbook (7^th Edition):

Chan, Jennifer Wing-Yee. “Design, fabrication, and characterization of bioactive amphiphilic polymers as cardiovascular therapeutics.” 2016. Web. 01 Mar 2021.

Vancouver:

Chan JW. Design, fabrication, and characterization of bioactive amphiphilic polymers as cardiovascular therapeutics. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Mar 01]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49920/.

Council of Science Editors:

Chan JW. Design, fabrication, and characterization of bioactive amphiphilic polymers as cardiovascular therapeutics. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49920/

Oregon State University

3. Bergman, Joshua J. Determining the activity distribution on a radioactive stent using plastic scintillation techniques.

Degree: MS, Radiation Health Physics, 2000, Oregon State University

URL: http://hdl.handle.net/1957/32951

► Re-occlusion of arteries following percutaneous transluminal coronary angioplasty (PTCA) remains a post-operative issue in the treatment of artery blockage. This re-narrowing of the luminal cavity,… (more)

▼ Re-occlusion of arteries following percutaneous transluminal coronary angioplasty (PTCA) remains a post-operative issue in the treatment of artery blockage. This re-narrowing of the luminal cavity, a condition called restenosis, has been attributed to the injury induced by PTCA balloon insertion. While arterial recoil can be completely prevented by a coronary stent, this device is ineffective in halting neointimal hyperplasia or vascular remodeling. However, recent studies have demonstrated that stenting in conjunction with radiation therapy to the injured artery can reduce smooth muscle cell (SMC) proliferation and the subsequent effects of the added extracellular matrix. Human and animal trial studies have shown that ³²P ion-implanted stainless steel stents are effective in reducing restenosis. Concerns regarding a non-uniform dose distribution from the short-range beta particles emitted from a stent's open geometry have resulted in the development of techniques to adequately determine stent surface activity distributions. Current methods rely on autoradiographic techniques using radiochromic foil exposure analysis. The purpose of this research was to determine the efficacy of employing electronically based detection methods for determining activity uniformity rather than foil exposure. A highly collimated solid organic scintillating plastic was optically coupled to a photomultiplier tube in order to detect beta emission from selected surface regions of a neutron-activated 316L stainless steel Guidant Multilink[superscript TM] stent. Irradiation of the stent activated ⁵⁵Mn, producing high energy, beta-emitting ⁵⁶Mn as a substitute for ³²P. Both Monte Carlo computer modeling and experimental results demonstrated that inconsistencies in activity attributed to stent geometry could be detected. Because a stent is comprised of repeating structures, this technique may be used to detect deficiencies in activity not associated with the predicted irregularities of activity caused by geometry. Such a detection device may be more appropriate and efficient in the industrial setting for quality assurance than current techniques using radiochromic film exposure. Advisors/Committee Members: Binney, Stephen E. (advisor).

Subjects/Keywords: Stents (Surgery)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bergman, J. J. (2000). Determining the activity distribution on a radioactive stent using plastic scintillation techniques. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/32951

Chicago Manual of Style (16^th Edition):

Bergman, Joshua J. “Determining the activity distribution on a radioactive stent using plastic scintillation techniques.” 2000. Masters Thesis, Oregon State University. Accessed March 01, 2021. http://hdl.handle.net/1957/32951.

MLA Handbook (7^th Edition):

Bergman, Joshua J. “Determining the activity distribution on a radioactive stent using plastic scintillation techniques.” 2000. Web. 01 Mar 2021.

Vancouver:

Bergman JJ. Determining the activity distribution on a radioactive stent using plastic scintillation techniques. [Internet] [Masters thesis]. Oregon State University; 2000. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1957/32951.

Council of Science Editors:

Bergman JJ. Determining the activity distribution on a radioactive stent using plastic scintillation techniques. [Masters Thesis]. Oregon State University; 2000. Available from: http://hdl.handle.net/1957/32951

Durban University of Technology

4. Harrypaul, Ashika. The assessment of two year clinical outcomes after stent implantation for the treatment of coronary artery disease.

Degree: 2013, Durban University of Technology

URL: http://hdl.handle.net/10321/812

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Submitted in fulfilment of the Master’s Degree in Clinical Technology, Durban University of Technology, 2012.

The sirolimus-eluting stent (Cypher) was the first approved drug- eluting… (more)

Subjects/Keywords: Stents (Surgery); Coronary heart disease – Treatment; Cardiology

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APA (6^th Edition):

Harrypaul, A. (2013). The assessment of two year clinical outcomes after stent implantation for the treatment of coronary artery disease. (Thesis). Durban University of Technology. Retrieved from http://hdl.handle.net/10321/812

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Harrypaul, Ashika. “The assessment of two year clinical outcomes after stent implantation for the treatment of coronary artery disease.” 2013. Thesis, Durban University of Technology. Accessed March 01, 2021. http://hdl.handle.net/10321/812.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Harrypaul, Ashika. “The assessment of two year clinical outcomes after stent implantation for the treatment of coronary artery disease.” 2013. Web. 01 Mar 2021.

Vancouver:

Harrypaul A. The assessment of two year clinical outcomes after stent implantation for the treatment of coronary artery disease. [Internet] [Thesis]. Durban University of Technology; 2013. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10321/812.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Harrypaul A. The assessment of two year clinical outcomes after stent implantation for the treatment of coronary artery disease. [Thesis]. Durban University of Technology; 2013. Available from: http://hdl.handle.net/10321/812

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

5. Thompson, Patrick Robert. Performance leakage for biospan-covered electrospun vascular stents in a pulsatile flow bioreactor.

Degree: 2014, Drexel University

URL: http://hdl.handle.net/1860/idea:6079

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In-stent restenosis occurs in 15-20% of “simple” coronary lesions, and in 30-60% of patients with complex lesions. Covered-stents reduce the rates of in-stent restenosis by… (more)

Subjects/Keywords: Biomedical engineering; Stents (Surgery); Blood flow

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APA (6^th Edition):

Thompson, P. R. (2014). Performance leakage for biospan-covered electrospun vascular stents in a pulsatile flow bioreactor. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:6079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thompson, Patrick Robert. “Performance leakage for biospan-covered electrospun vascular stents in a pulsatile flow bioreactor.” 2014. Thesis, Drexel University. Accessed March 01, 2021. http://hdl.handle.net/1860/idea:6079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thompson, Patrick Robert. “Performance leakage for biospan-covered electrospun vascular stents in a pulsatile flow bioreactor.” 2014. Web. 01 Mar 2021.

Vancouver:

Thompson PR. Performance leakage for biospan-covered electrospun vascular stents in a pulsatile flow bioreactor. [Internet] [Thesis]. Drexel University; 2014. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1860/idea:6079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thompson PR. Performance leakage for biospan-covered electrospun vascular stents in a pulsatile flow bioreactor. [Thesis]. Drexel University; 2014. Available from: http://hdl.handle.net/1860/idea:6079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Halwani, Dina O. Characterization of explanted endovascular stents : a study of in-vivo corrosion and the role of vascular calcification in stent fracture.

Degree: PhD, 2010, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,815

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The electrochemical and mechanical stability of endovascular stents in-vivo is essential for their biocompatibility. Limited information is available regarding the condition of stents following interaction… (more)

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The electrochemical and mechanical stability of endovascular stents in-vivo is essential for their biocompatibility. Limited information is available regarding the condition of stents following interaction with vascular tissue, as a result, twenty seven stented vessels containing 45 stents (33 bare metal and 12 drug eluting) were retrieved during autopsy and vascular surgery. The stent/tissue components were carefully separated using a rigorous tissue dissolution protocol. Stent surfaces were characterized using 3D digital optical and scanning electron microscopy. Transferred metallic elements in dissolved tissue were measured using mass spectroscopy. Histopathologic assessment of stented tissue, when available, was also performed. Fifteen out of the 33 bare metal stents underwent in-vivo corrosion (n=12) and fractures (n=3). Seven out of the 12 drug eluting stents had fractures. Microscopy images revealed mainly pitting and galvanic corrosion. Mechanical damage such as fretting of stents either overlapping other stents or vascular calcification was also observed. Tissue surrounding corroded stents contained a higher level of transferred metallic elements when compared to control and non-corroded samples. Multiple strut fracture occurred in stents placed in an overlapping configurat ion and/or under the presence of diffuse calcification. Fracture surfaces were consistent with a fatigue mechanism. Deposition of calcified matter on the stent struts was found to be a pattern in fractured cases. Tissue sections, at or near fracture sites, revealed development of in-stent restenosis and/or thrombosis. Electrochemical and mechanically-induced corrosion was observed on explanted stents. Heavy calcification appeared to contribute to stent fatigue and fracture. Both corrosion and fracture may impact the structural integrity of stents and influence local tissue responses.

1 online resource (x, 105 p.) : ill. (some col.), facsims.

Biomedical Engineering

Engineering

UNRESTRICTED

Advisors/Committee Members: Anayiotos, Andreas S., Anderson, Peter G. , Brott, Brigitta C. , Lemons, Jack E. , Venugopalan, Ramakrishna.

Subjects/Keywords: Stents (Surgery) – Materials – Corrosion <; br>; Stents (Surgery) – Materials – Fracture <; br>; Stents (Surgery) – Materials – Biocompatibility <; br>; Blood-vessels – Calcification <; br>; Blood-vessels – Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Halwani, D. O. (2010). Characterization of explanted endovascular stents : a study of in-vivo corrosion and the role of vascular calcification in stent fracture. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,815

Chicago Manual of Style (16^th Edition):

Halwani, Dina O. “Characterization of explanted endovascular stents : a study of in-vivo corrosion and the role of vascular calcification in stent fracture.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,815.

MLA Handbook (7^th Edition):

Halwani, Dina O. “Characterization of explanted endovascular stents : a study of in-vivo corrosion and the role of vascular calcification in stent fracture.” 2010. Web. 01 Mar 2021.

Vancouver:

Halwani DO. Characterization of explanted endovascular stents : a study of in-vivo corrosion and the role of vascular calcification in stent fracture. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,815.

Council of Science Editors:

Halwani DO. Characterization of explanted endovascular stents : a study of in-vivo corrosion and the role of vascular calcification in stent fracture. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,815

University of Hong Kong

7. Leung, Kar-ming. Stent assisted coiling for wide-neck cerebral aneurysms.

Degree: 2009, University of Hong Kong

URL: http://hdl.handle.net/10722/56987

Subjects/Keywords: Intracranial aneurysms.; Stents (Surgery)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leung, K. (2009). Stent assisted coiling for wide-neck cerebral aneurysms. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/56987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leung, Kar-ming. “Stent assisted coiling for wide-neck cerebral aneurysms.” 2009. Thesis, University of Hong Kong. Accessed March 01, 2021. http://hdl.handle.net/10722/56987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leung, Kar-ming. “Stent assisted coiling for wide-neck cerebral aneurysms.” 2009. Web. 01 Mar 2021.

Vancouver:

Leung K. Stent assisted coiling for wide-neck cerebral aneurysms. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10722/56987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leung K. Stent assisted coiling for wide-neck cerebral aneurysms. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/56987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

8. Canena, Jorge Manuel Tavares . Próteses no tubo digestivo: evolução e aplicações no século XXI .

Degree: 2012, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/7874

► RESUMO: A utilização das próteses metálicas auto-expansíveis é um tratamento paliativo e definitivo muito eficaz em doentes com obstrução maligna coló-retal e gastroduodenal. Este tratamento… (more)

Subjects/Keywords: Gastrointestinal Neoplasms - surgery; Endoscopy, Gastrointestinal - methods; Stents; Gastrenterologia

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APA (6^th Edition):

Canena, J. M. T. (2012). Próteses no tubo digestivo: evolução e aplicações no século XXI . (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/7874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Canena, Jorge Manuel Tavares . “Próteses no tubo digestivo: evolução e aplicações no século XXI .” 2012. Thesis, Universidade Nova. Accessed March 01, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/7874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Canena, Jorge Manuel Tavares . “Próteses no tubo digestivo: evolução e aplicações no século XXI .” 2012. Web. 01 Mar 2021.

Vancouver:

Canena JMT. Próteses no tubo digestivo: evolução e aplicações no século XXI . [Internet] [Thesis]. Universidade Nova; 2012. [cited 2021 Mar 01]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/7874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Canena JMT. Próteses no tubo digestivo: evolução e aplicações no século XXI . [Thesis]. Universidade Nova; 2012. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/7874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

9. Rayepalli, Sagar. Experimental investigation of flow in a rectangular cavity with a porous opening.

Degree: MS, Department of Mechanical Engineering, 2007, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:38776

Subjects/Keywords: Stents (Surgery) – Fluid dynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rayepalli, S. (2007). Experimental investigation of flow in a rectangular cavity with a porous opening. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:38776

Chicago Manual of Style (16^th Edition):

Rayepalli, Sagar. “Experimental investigation of flow in a rectangular cavity with a porous opening.” 2007. Masters Thesis, Michigan State University. Accessed March 01, 2021. http://etd.lib.msu.edu/islandora/object/etd:38776.

MLA Handbook (7^th Edition):

Rayepalli, Sagar. “Experimental investigation of flow in a rectangular cavity with a porous opening.” 2007. Web. 01 Mar 2021.

Vancouver:

Rayepalli S. Experimental investigation of flow in a rectangular cavity with a porous opening. [Internet] [Masters thesis]. Michigan State University; 2007. [cited 2021 Mar 01]. Available from: http://etd.lib.msu.edu/islandora/object/etd:38776.

Council of Science Editors:

Rayepalli S. Experimental investigation of flow in a rectangular cavity with a porous opening. [Masters Thesis]. Michigan State University; 2007. Available from: http://etd.lib.msu.edu/islandora/object/etd:38776

University of Hong Kong

10. 庆开雄. Thoracic endovascular stent graft repair (TEVAR) for treating type B aortic dissections (TBAD) : a hemodynamic and morphologic perspective.

Degree: 2013, University of Hong Kong

URL: http://hdl.handle.net/10722/197128

► TEVAR has been used extensively to treat TBAD. The principle of treatment involve placement of a stent graft in the true lumen to cover the… (more)

▼ TEVAR has been used extensively to treat TBAD. The principle of treatment involve placement of a stent graft in the true lumen to cover the primary tear, thereby excluding the false lumen. Success depends on a combination of factors: reduction of false lumen pressure and perfusion, thrombosis of the false lumen, and remodeling of the aorta leading to eventual healing. The long-term goals are to prevent continuous growth of the false lumen, reinterventions, and aneurysm rupture. The success of TEVAR depends on a combination of factors, including the blood flow and pressure in the two aortic lumens, and remodeling is a dynamic process. Much controversy exists regarding the ideal timing of TEVAR, its efficacy in effecting complete false lumen exclusion, the long-term durability of the repair, and the fate of the aortic size. The objective of this thesis is to examine the morphological and hemodynamic changes within the aortic lumens after TEVAR, using a combination of ex-vivo animal models and computational tomography analysis. The residual pressure of the true and false lumens in TBAD models was studied. Volumetric analyses of CT scan of patients were compared. The ultimate goals are to determine if it is beneficial to treat type B dissections early, and to determine long-term morphological results. In ex-vivo hemodynamic study, 28 fresh porcine aortas models were created to simulate three different pathological scenarios of TBAD: model A represented pre-treated TBAD; model B represented post-treated TBAD with patent false lumen; and model C represented chronic stage of post-treated TBAD with false lumen thrombosis. True lumen and false lumen pressure differences were compared between the three models. Pressure effect was successfully reduced by 30% in model C in comparison with the other two models. No hemodynamic parameters were significantly different between model A and model B. Aortic remodeling parameters were volumetrically analyzed and compared between two groups of patients who underwent endo-grafting for uncomplicated TBAD (group A) and dissecting aneurysms (group B). Modern DIOCM processing workstations and software were used to reconstruct thoracic aorta with serial CT scans. The true lumen, false lumen, thrombus and aortic size were measured volumetrically. Stent graft migration and area of inlet and outlet were also quantified. There were progressive migration and continuous expansion of the stent graft on patients in both groups. Favorable aortic remodeling was observed in most. One fourth of all patients demonstrated aortic volume increase at 36 months. However, there was no difference between group A and group B in terms of stent graft re-shaping and aortic remodeling. In conclusion, Aortic remodeling after TEVAR in treating TBAD is a continuous process. There were no significant differences between chronic dissections and dissecting aneurysms in all morphological parameters. Treating chronic dissections before aneurysm formation does not seem to have a morphologic advantage. Sealing of…

Subjects/Keywords: Stents (Surgery); Dissecting aortic aneurysms - Surgery

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APA (6^th Edition):

庆开雄. (2013). Thoracic endovascular stent graft repair (TEVAR) for treating type B aortic dissections (TBAD) : a hemodynamic and morphologic perspective. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/197128

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

庆开雄. “Thoracic endovascular stent graft repair (TEVAR) for treating type B aortic dissections (TBAD) : a hemodynamic and morphologic perspective.” 2013. Thesis, University of Hong Kong. Accessed March 01, 2021. http://hdl.handle.net/10722/197128.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

庆开雄. “Thoracic endovascular stent graft repair (TEVAR) for treating type B aortic dissections (TBAD) : a hemodynamic and morphologic perspective.” 2013. Web. 01 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

庆开雄. Thoracic endovascular stent graft repair (TEVAR) for treating type B aortic dissections (TBAD) : a hemodynamic and morphologic perspective. [Internet] [Thesis]. University of Hong Kong; 2013. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10722/197128.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

庆开雄. Thoracic endovascular stent graft repair (TEVAR) for treating type B aortic dissections (TBAD) : a hemodynamic and morphologic perspective. [Thesis]. University of Hong Kong; 2013. Available from: http://hdl.handle.net/10722/197128

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

11. Kiemeneij, Ferdinand. Towards optimalization of clinical outcome after Palmaz Schatz coronary stent implantation.

Degree: 1995, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/21765

Subjects/Keywords: cardiology; coronary diseases; heart surgery; stents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kiemeneij, F. (1995). Towards optimalization of clinical outcome after Palmaz Schatz coronary stent implantation. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/21765

Chicago Manual of Style (16^th Edition):

Kiemeneij, Ferdinand. “Towards optimalization of clinical outcome after Palmaz Schatz coronary stent implantation.” 1995. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 01, 2021. http://hdl.handle.net/1765/21765.

MLA Handbook (7^th Edition):

Kiemeneij, Ferdinand. “Towards optimalization of clinical outcome after Palmaz Schatz coronary stent implantation.” 1995. Web. 01 Mar 2021.

Vancouver:

Kiemeneij F. Towards optimalization of clinical outcome after Palmaz Schatz coronary stent implantation. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1995. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1765/21765.

Council of Science Editors:

Kiemeneij F. Towards optimalization of clinical outcome after Palmaz Schatz coronary stent implantation. [Doctoral Dissertation]. Erasmus University Medical Center; 1995. Available from: http://hdl.handle.net/1765/21765

Universitat de Barcelona

12. Yugueros Castellnou, Xavier. Estudio experimental in vitro de la técnica del stent paralelo en la reparación endovascular de los aneurismas de la aorta abdominal.

Degree: 2019, Universitat de Barcelona

URL: http://hdl.handle.net/10803/669918

► Parallel stenting is a surgical procedure used in endovascular repair of complex abdominal aortic aneurysms. The objective of this study has been to evaluate, using… (more)

▼ Parallel stenting is a surgical procedure used in endovascular repair of complex abdominal aortic aneurysms. The objective of this study has been to evaluate, using in vitro models, some critical technical aspects (oversizing degree, the best way to measure as well as best device combination) in two parallel stent different configurations: 2 and 3 visceral chimneys (chEVAR) and in a sandwich configuration to preserve the hypogastric artery. Synthetic models of a visceral aorta and an iliac extension were constructed following the usual anatomical diameters and characteristics. In them, different devices with different oversizing degree were introduced, reproducing the same procedure and simulating the same physiological conditions as in vivo. The analysis of each reconstruction was performed using computed tomography (CT) and image processing software. Main variables were gutter area (area not covered by either the parallel stent or the main endograft), stent compression and malpositioning or infolding (internal folding of the main endograft generating new gutters). Regarding 2-3 visceral chimney configuration, 30% was the best oversizing degree, reducing gutter area to the minimum without significant branch compression or infolding. Analyzing best device combination, balloon expandable stents and high radial force endografts, were associated with less compression than low radial force materials but at the expense of a significantly larger gutter area. Regarding sandwich configuration to preserve hypogastric flow, our results showed that 30 - 55% diameter oversizing was the best, being associated with less gutter area without significant visceral branch compression or infolding. Analyzing oversizing measuring methods, a practically perfect correlation was obtained between all of them, (areas, perimeters and diameters) recommending the use of the latter as significantly simplifying procedure planning. Regarding device combinations, no clear differences were obtained excepting a non-significant tendency to lower infolding with self-expanding stents for the internal iliac artery. Advisors/Committee Members: Universitat de Barcelona. Facultat de Medicina, [email protected] (authoremail), false (authoremailshow), Mestres Alomar, Gaspar (director), Riambau, Vicente (director).

Subjects/Keywords: Fisiologia patològica; Fisiología patológica; Pathological physiology; Aneurismes aòrtics; Aneurismas aórticos; Aortic aneurysms; Pròtesis de Stent; Stents; Stents (Surgery); Ciències de la Salut; 616.1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yugueros Castellnou, X. (2019). Estudio experimental in vitro de la técnica del stent paralelo en la reparación endovascular de los aneurismas de la aorta abdominal. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/669918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yugueros Castellnou, Xavier. “Estudio experimental in vitro de la técnica del stent paralelo en la reparación endovascular de los aneurismas de la aorta abdominal.” 2019. Thesis, Universitat de Barcelona. Accessed March 01, 2021. http://hdl.handle.net/10803/669918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yugueros Castellnou, Xavier. “Estudio experimental in vitro de la técnica del stent paralelo en la reparación endovascular de los aneurismas de la aorta abdominal.” 2019. Web. 01 Mar 2021.

Vancouver:

Yugueros Castellnou X. Estudio experimental in vitro de la técnica del stent paralelo en la reparación endovascular de los aneurismas de la aorta abdominal. [Internet] [Thesis]. Universitat de Barcelona; 2019. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10803/669918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yugueros Castellnou X. Estudio experimental in vitro de la técnica del stent paralelo en la reparación endovascular de los aneurismas de la aorta abdominal. [Thesis]. Universitat de Barcelona; 2019. Available from: http://hdl.handle.net/10803/669918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of North Texas

13. Yang, Hua. Study of Mechanical Performance of Stent Implants Using Theoretical and Numerical Approach.

Degree: 2015, University of North Texas

URL: https://digital.library.unt.edu/ark:/67531/metadc804879/

► The coronary heart disease kills more than 350,000 persons/year and it costs $108.9 billion for the United States each year, in spite of significant advancements… (more)

▼ The coronary heart disease kills more than 350,000 persons/year and it costs $108.9 billion for the United States each year, in spite of significant advancements in clinical care and education for public, cardiovascular diseases (CVD) are leading cause of death and disability to the nation. A cardiovascular disease involves mainly heart or blood vessels (arteries, veins and capillaries) or both, and then mainly occurs in selected regions and affects heart, brain, kidney and peripheral arteries. As a surgical interventions, stent implantation is deployed to cure or ameliorate the disease. However, the high failure rate of stents used in patients with peripheral artery diseases has lead researchers to give special attention towards analyzing stent structure and characteristics. In this research, the mechanical properties of a stent based on the rhombus structure were analyzed and verified by means of analytical and numerical approaches. Theoretical model based on the beam theory were developed and numerical models were used to analyze the response of these structures under various and complex loading conditions. Moreover, the analysis of the stent inflation involves a model with large deformations and large strains, nonlinear material properties need to be considered to accurately capture the deformation process. The maximum stress values were found to occur in localized regions of the stent. These regions were generally found along the inner radii of each of the connected links connecting each of the longitudinal struts. Stress values throughout the whole stent were typically much lower. The peak engineering stress values were found to be less than the material ultimate strength (limit stress 515Mpa), indicating a safe stent design throughout expansion range. Lastly, the rheological behavior of blood can be quantified by non-Newtonian viscosity. Carreau model is introduced and simulates the situation in the artery, then the available shear stress in the model would help to the future analysis in the contact analysis of stent and the artery. Advisors/Committee Members: Fortier, Aleksandra, Horne, Kyle, Aouadi, Samir.

Subjects/Keywords: Stent implants; rhombus structure; cardiovascular disease; non-Newtonian flow; Stents (Surgery) – Mechanical properties.; Biomedical materials – Mechanical properties.; Cardiovascular system – Surgery.; Heart – Surgery.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, H. (2015). Study of Mechanical Performance of Stent Implants Using Theoretical and Numerical Approach. (Thesis). University of North Texas. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc804879/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Hua. “Study of Mechanical Performance of Stent Implants Using Theoretical and Numerical Approach.” 2015. Thesis, University of North Texas. Accessed March 01, 2021. https://digital.library.unt.edu/ark:/67531/metadc804879/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Hua. “Study of Mechanical Performance of Stent Implants Using Theoretical and Numerical Approach.” 2015. Web. 01 Mar 2021.

Vancouver:

Yang H. Study of Mechanical Performance of Stent Implants Using Theoretical and Numerical Approach. [Internet] [Thesis]. University of North Texas; 2015. [cited 2021 Mar 01]. Available from: https://digital.library.unt.edu/ark:/67531/metadc804879/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang H. Study of Mechanical Performance of Stent Implants Using Theoretical and Numerical Approach. [Thesis]. University of North Texas; 2015. Available from: https://digital.library.unt.edu/ark:/67531/metadc804879/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Shin, Minchul. MRI evaluation of a stented abdominal aorta of a rabbit.

Degree: MS, 2007, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,537

►

Magnetic resonance imaging (MRI) is an attractive non-invasive angiographic device, not requiring nephrotoxic contrast agents and damaging exposure to radiation such as traditional angiography and… (more)

Subjects/Keywords: Blood-vessels – Stenosis – Measurement <; br>; Magnetic resonance imaging <; br>; Stents (Surgery) <; br>; Rabbits – Cardiovascular system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shin, M. (2007). MRI evaluation of a stented abdominal aorta of a rabbit. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,537

Chicago Manual of Style (16^th Edition):

Shin, Minchul. “MRI evaluation of a stented abdominal aorta of a rabbit.” 2007. Masters Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,537.

MLA Handbook (7^th Edition):

Shin, Minchul. “MRI evaluation of a stented abdominal aorta of a rabbit.” 2007. Web. 01 Mar 2021.

Vancouver:

Shin M. MRI evaluation of a stented abdominal aorta of a rabbit. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2007. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,537.

Council of Science Editors:

Shin M. MRI evaluation of a stented abdominal aorta of a rabbit. [Masters Thesis]. University of Alabama – Birmingham; 2007. Available from: http://contentdm.mhsl.uab.edu/u?/etd,537

University of Hong Kong

15. 林省京. Computational fluid dynamic analyses of the endovascular stent-graft at the thoracic aorta with different biomechanical factors.

Degree: 2008, University of Hong Kong

URL: http://hdl.handle.net/10722/54652

Subjects/Keywords: Hemodynamics.; Thoracic arteries.; Stents (Surgery) - Fluid dynamics.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

林省京.. (2008). Computational fluid dynamic analyses of the endovascular stent-graft at the thoracic aorta with different biomechanical factors. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/54652

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

林省京.. “Computational fluid dynamic analyses of the endovascular stent-graft at the thoracic aorta with different biomechanical factors.” 2008. Thesis, University of Hong Kong. Accessed March 01, 2021. http://hdl.handle.net/10722/54652.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

林省京.. “Computational fluid dynamic analyses of the endovascular stent-graft at the thoracic aorta with different biomechanical factors.” 2008. Web. 01 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

林省京.. Computational fluid dynamic analyses of the endovascular stent-graft at the thoracic aorta with different biomechanical factors. [Internet] [Thesis]. University of Hong Kong; 2008. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10722/54652.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

林省京.. Computational fluid dynamic analyses of the endovascular stent-graft at the thoracic aorta with different biomechanical factors. [Thesis]. University of Hong Kong; 2008. Available from: http://hdl.handle.net/10722/54652

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Kansas City

16. Grodzinsky, Anna. Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy.

Degree: 2015, University of Missouri – Kansas City

URL: http://hdl.handle.net/10355/46326

► Patients with diabetes (DM) experience higher rates of in-stent restenosis and therefore greater benefit from drug eluting stent (DES) implant at the time of percutaneous… (more)

▼ Patients with diabetes (DM) experience higher rates of in-stent restenosis and therefore greater benefit from drug eluting stent (DES) implant at the time of percutaneous coronary intervention (PCI). DES stent implantation necessitates prolonged dual anti-platelet therapy (DAPT). While DAPT reduces the risk of ischemic events post-PCI, it also increases the risk for bleeding. Whether long-term rates of bleeding differ among patients with and without DM receiving DAPT in real-world practice is unknown. Among patients who underwent PCI and were maintained on DAPT for 1 year in a multicenter US PCI registry, OPS/PRISM, we assessed patient-reported bleeding (defined according to the Bleeding Academic Research Consortium, BARC) over the year following PCI in patients with and without DM. Bleeding assessments were conducted by a study coordinator at index hospitalization (baseline) and at 1, 6 and 12 months following discharge. Multivariable logistic regression was used to evaluate the association of DM with bleeding during follow-up. In a sensitivity analysis, we excluded bruising from BARC-defined bleeding events. Covariates included in the model were selected a priori and were abstracted from the medical record by study coordinators. Covariates included demographic (e.g. age, insurance status) and clinical (e.g. medical history, procedural indication) variables. Among 2270 PCI patients (mean age 64, 72% male, 54% ACS), 32.6% had DM. In unadjusted analyses, patients with DM had fewer BARC ≥1 bleeding events over the year following PCI (DM vs no DM: BARC ≥1: 77.7% vs 87.6%, p<0.001; BARC ≥ 2: 4.5% vs 5.3%, p=0.41). After adjusting for demographic and clinical factors, patients with DM had lower odds of BARC ≥1 bleeding during follow-up (odds ratio [OR] 0.52, 95% CI 0.39-0.68, p<0.001 vs. no DM). This decreased odds of bleeding persisted after removing bruising from the endpoint definition (OR 0.77, 95% CI 0.62-0.96). In a real-world PCI registry, patients with DM experienced lower bleeding on DAPT than those without DM. As patients with DM also derive greater ischemic benefit from DES, which requires prolonged DAPT, our findings suggest that the balance between benefit and risk of this therapeutic approach is even more favorable in patients with DM than previously considered. Advisors/Committee Members: Smolderen, Kim G. (advisor).

Subjects/Keywords: Hemorrhage; Stents (Surgery); Diabetes – Complications; Percutaneous Coronary Intervention; Hemorrhage; Diabetes Complications; Thesis – University of Missouri – Kansas City – Medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grodzinsky, A. (2015). Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy. (Thesis). University of Missouri – Kansas City. Retrieved from http://hdl.handle.net/10355/46326

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grodzinsky, Anna. “Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy.” 2015. Thesis, University of Missouri – Kansas City. Accessed March 01, 2021. http://hdl.handle.net/10355/46326.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grodzinsky, Anna. “Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy.” 2015. Web. 01 Mar 2021.

Vancouver:

Grodzinsky A. Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy. [Internet] [Thesis]. University of Missouri – Kansas City; 2015. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10355/46326.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grodzinsky A. Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy. [Thesis]. University of Missouri – Kansas City; 2015. Available from: http://hdl.handle.net/10355/46326

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of North Texas

17. Alagarsamy, Karthik. Application of High Entropy Alloys in Stent Implants.

Degree: 2017, University of North Texas

URL: https://digital.library.unt.edu/ark:/67531/metadc984159/

► High entropy alloys (HEAs) are alloys with five or more principal elements. Due to these distinct concept of alloying, the HEA exhibits unique and superior… (more)

Subjects/Keywords: High entropy alloys; stent implants; fatigue life; computational modeling; Engineering, Mechanical; Engineering, Materials Science; Engineering, Biomedical; Alloys.; Stents (Surgery); Biomedical materials.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alagarsamy, K. (2017). Application of High Entropy Alloys in Stent Implants. (Thesis). University of North Texas. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc984159/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alagarsamy, Karthik. “Application of High Entropy Alloys in Stent Implants.” 2017. Thesis, University of North Texas. Accessed March 01, 2021. https://digital.library.unt.edu/ark:/67531/metadc984159/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alagarsamy, Karthik. “Application of High Entropy Alloys in Stent Implants.” 2017. Web. 01 Mar 2021.

Vancouver:

Alagarsamy K. Application of High Entropy Alloys in Stent Implants. [Internet] [Thesis]. University of North Texas; 2017. [cited 2021 Mar 01]. Available from: https://digital.library.unt.edu/ark:/67531/metadc984159/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alagarsamy K. Application of High Entropy Alloys in Stent Implants. [Thesis]. University of North Texas; 2017. Available from: https://digital.library.unt.edu/ark:/67531/metadc984159/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Macquarie University

18. Zhang, Mingzi. Haemodynamic simulation and optimisation for the flow-diversion treatment of intracranial aneurysms.

Degree: 2018, Macquarie University

URL: http://hdl.handle.net/1959.14/1274879

►

Empirical thesis.

Thesis carried out as part of a co-tutelle arrangement with Tohoku University.

Bibliography: pages 125-136.

Chapter 1. Introduction – Chapter 2. Materials and… (more)

▼

Empirical thesis.

Thesis carried out as part of a co-tutelle arrangement with Tohoku University.

Bibliography: pages 125-136.

Chapter 1. Introduction – Chapter 2. Materials and methods – Chapter 3. Structural optimisation of flow-diverting stent – Chapter 4. Haemodynamic simulation of flow-diversion treatments with stent compaction applied – Chapter 5. Haemodynamic simulation of flow-diversion treatment with multiple flow-diverting stents – Chapter 6. Investigation of incomplete stent expansion effects on aneurysmal haemodynamics – Chapter 7. Applying computational simulation to the design of flow-diversion Tteatment : a showcase – Chapter 8. Conclusion and outlook.

Despite various complications reported, flow-diverting (FD) stent implantation has become a major mode of treatment for intracranial aneurysms. Review of literature suggests that the treatment outcomes are closely associated with the aneurysmal haemodynamics changed by the implanted stent. In this thesis, I sought to examine the haemodynamic changes following different strategies of FD treatment and provide practical solutions to improve the stent's flow-diversion efficacy.

As the first accomplishment, I developed in Chapter 3 an automated optimisation method to be used to accommodate stent configuration to a specific aneurysm geometry. Adopting this method, wire structure of a stent can be modified to alter the local haemodynamics towards maximal reduction of the aneurysmal inflow. Furthermore, employing a virtual stent deployment technique and computational fluid dynamics analysis, I systematically investigated in Chapter 4 and 5 the aneurysmal haemodynamics following the flow-diversion treatment with a stent compaction technique applied or with dual-FD stents deployed - two of the most commonly adopted treatment strategies in the current interventional practice. These studies provided quantitative results illustrating stent wire characteristics and the subsequent aneurysmal haemodynamic changes in various flow-diversion scenarios. Finally, I examined in Chapter 6 the aneurysmal haemodynamics affected by incomplete stent expansion (IncSE) - a condition suspected to cause delayed aneurysm occlusion, for which various severities of IncSE occurring at different segments of the parent artery were modelled and examined. Results suggest that the effects of IncSE vary greatly with respect to the location where it occurs.

Based upon this series of studies, a workflow was put forward to individualise the treatment plan corresponding to the haemodynamic characteristics of a specific patient, from the patient aneurysm model reconstruction, to computer-aided stent deployment rehearsal, and then to the haemodynamic outcome analysis to determine the most effective treatment plan prior to the real treatment. An example of implementing this workflow to predict the post-treatment haemodynamics thereby determining the most favourable treatment strategy was illustrated in detail in Chapter 7.

Apart from this useful application,…

Advisors/Committee Members: Macquarie University. Department of Biomedical Sciences, Tōhoku Daigaku.

Subjects/Keywords: Stents (Surgery) – Fluid dynamics; Intracranial aneurysms – Treatment; computational fluid dynamics (CFD); haemodynamics; flow-diversion treatment; intracranial aneurysms; design optimisation; treatment planning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, M. (2018). Haemodynamic simulation and optimisation for the flow-diversion treatment of intracranial aneurysms. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1274879

Chicago Manual of Style (16^th Edition):

Zhang, Mingzi. “Haemodynamic simulation and optimisation for the flow-diversion treatment of intracranial aneurysms.” 2018. Doctoral Dissertation, Macquarie University. Accessed March 01, 2021. http://hdl.handle.net/1959.14/1274879.

MLA Handbook (7^th Edition):

Zhang, Mingzi. “Haemodynamic simulation and optimisation for the flow-diversion treatment of intracranial aneurysms.” 2018. Web. 01 Mar 2021.

Vancouver:

Zhang M. Haemodynamic simulation and optimisation for the flow-diversion treatment of intracranial aneurysms. [Internet] [Doctoral dissertation]. Macquarie University; 2018. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1959.14/1274879.

Council of Science Editors:

Zhang M. Haemodynamic simulation and optimisation for the flow-diversion treatment of intracranial aneurysms. [Doctoral Dissertation]. Macquarie University; 2018. Available from: http://hdl.handle.net/1959.14/1274879

University of New South Wales

19. Huang, Henry Yen-Chin. Theoretical and experimental modelling of stress within the neck of endoluminal grafted artery.

Degree: Graduate School of Biomedical Engineering, 2006, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/29146 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1377/SOURCE02?view=true

► The success of endoluminal stent-graft treatment for abdominal aortic aneurysm relies on maintenance of an effective seal when the stent expands into the healthy artery.… (more)

▼ The success of endoluminal stent-graft treatment for abdominal aortic aneurysm relies on maintenance of an effective seal when the stent expands into the healthy artery. Clinical observation of aortic neck dilation following endoluminal grafting has led to the hypothesis that excessive stent expansion forces may cause remodelling and dilation of the artery to accommodate the strong forces. This may lead to failure of the seal, hence so-called endoleak. In this research, we analysed the force field generated by aortic stent-grafts and investigated in vitro approaches for studying the effects of these forces on cells within the vascular wall. The pressure-deformation behaviour of ovine arteries was examined experimentally and was found to vary with artery type. A finite element model of abdominal aorta (AA) characterised by Mooney-Rivlin hyperelastic material properties was validated. The property inputs were derived from the polynomial form of the strain energy density function proposed by Patel and Vaishnav.Stent-artery contact simulations revealed stresses 1.2-19 times higher than within a normal vessel at 120 mmHg when contacted by a zig-zag, square cross-section stent that expanded the AA by 3-16%. Streses 1.3-23 times normal were predicted for circular cross-section stents at the same range of expansions. The stress distribution was determined to be concentrated at the contacting surface and within the inner region of the aortic wall. These results confirmed that the forces within the vessel wall are likely to place unnatural physiological demands on the cells within. We then developed an in vitro system for studying the impact of this mechanical stress on cells within a three dimensional (3D) structure.A 20 wt% poly(vinyl alcohol) (PVA) - 5 wt% collagen tubular construct was developed to support cells, and was shown to sustain physiological blood pressures. Two cell-seeding techniques were examined, direct cell encapsulation and surface cell-seeding. Both demonstrated the capability of entrapping viable cells within the construct that remained viable for up to 4 days. In conclusion, stent contact does create abnormal stress concentrations within the vessel wall with a magnitude severely higher than physiological levels. A feasible tubular construct and an in vitro system were developed, enabling further assessments on the effects of these abnormality on the cells.

Subjects/Keywords: Arterial grafts; Aortic aneurysms; Stents (Surgery); Stress (Physiology)

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APA (6^th Edition):

Huang, H. Y. (2006). Theoretical and experimental modelling of stress within the neck of endoluminal grafted artery. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/29146 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1377/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Huang, Henry Yen-Chin. “Theoretical and experimental modelling of stress within the neck of endoluminal grafted artery.” 2006. Doctoral Dissertation, University of New South Wales. Accessed March 01, 2021. http://handle.unsw.edu.au/1959.4/29146 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1377/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Huang, Henry Yen-Chin. “Theoretical and experimental modelling of stress within the neck of endoluminal grafted artery.” 2006. Web. 01 Mar 2021.

Vancouver:

Huang HY. Theoretical and experimental modelling of stress within the neck of endoluminal grafted artery. [Internet] [Doctoral dissertation]. University of New South Wales; 2006. [cited 2021 Mar 01]. Available from: http://handle.unsw.edu.au/1959.4/29146 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1377/SOURCE02?view=true.

Council of Science Editors:

Huang HY. Theoretical and experimental modelling of stress within the neck of endoluminal grafted artery. [Doctoral Dissertation]. University of New South Wales; 2006. Available from: http://handle.unsw.edu.au/1959.4/29146 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1377/SOURCE02?view=true

Stellenbosch University

20. Esterhuyse, Anton. Structural design of a stent for a percutaneous aortic heart valve.

Degree: Mechanical and Mechatronic Engineering, 2009, Stellenbosch University

URL: http://hdl.handle.net/10019.1/2706

►

Thesis (MScEng (Mechanical and Mechatronic Engineering)) – University of Stellenbosch, 2009.

Elderly patients suffering from aortic valvular dysfunction are often denied aortic valve replacement due to… (more)

▼

Thesis (MScEng (Mechanical and Mechatronic Engineering)) – University of Stellenbosch, 2009.

Elderly patients suffering from aortic valvular dysfunction are often denied aortic valve replacement due to the fact that they are classified as too old and fragile to handle the physical stress of open-heart surgery and cardio-pulmonary bypass. There exists a need for an alternative solution which places less physical stress on the body. The development of a percutaneous aortic heart valve (PAHV), which may be implanted through a minimally invasive procedure, will provide a solution to old and fragile patients who otherwise have a very limited life expectancy. The development of such a device entails a costly and time-consuming process which involves a number of phases, including a prototype development phase, an in-vitro testing phase, an animal trial phase and a human trial phase. This thesis focuses on the design and analysis of the stent component for a PAHV, suitable for implantation in sheep (animal trial phase). The process of developing a first prototype, involved an analysis of the stent design requirements. This analysis was followed by a concept generation phase as well as comprehensive finite element (FE) analyses of the most promising concepts. The objective of the FE analyses was to determine the effects of a variation in strut width on the performance characteristics of the concepts. Based on the results of the FE analyses, final geometries were selected for each of the two most promising concepts. Subsequent to the selection of the final geometries, a number of prototypes were manufactured. The prototypes were subjected to an electro-polishing process. An experimental analysis was also conducted on the prototypes to evaluate the accuracy of the (FE) simulations as well as the actual performance of the stent prototypes. The results of the FE analyses and experimental analyses indicated that strut width had a substantial influence on the parameters that were defined to characterise stent performance. The results of the analyses also highlighted the advantages and disadvantages of each concept and aided in identifying the concept that would be most suitable for the required application. Limitations of the study were identified and recommendations were made to assist the continued research and development of the device.

Advisors/Committee Members: Scheffer, C., Van der Westhuizen, K., University of Stellenbosch. Faculty of Engineering. Dept. of Mechanical and Mechatronic Engineering..

Subjects/Keywords: Mechanical engineering; Heart – Surgery; Stents (Surgery); Aortic valve; Mechanical and Mechatronic Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Esterhuyse, A. (2009). Structural design of a stent for a percutaneous aortic heart valve. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/2706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Esterhuyse, Anton. “Structural design of a stent for a percutaneous aortic heart valve.” 2009. Thesis, Stellenbosch University. Accessed March 01, 2021. http://hdl.handle.net/10019.1/2706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Esterhuyse, Anton. “Structural design of a stent for a percutaneous aortic heart valve.” 2009. Web. 01 Mar 2021.

Vancouver:

Esterhuyse A. Structural design of a stent for a percutaneous aortic heart valve. [Internet] [Thesis]. Stellenbosch University; 2009. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10019.1/2706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Esterhuyse A. Structural design of a stent for a percutaneous aortic heart valve. [Thesis]. Stellenbosch University; 2009. Available from: http://hdl.handle.net/10019.1/2706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

21. Russ, Jonathan Brent. Computational Design of Structures for Enhanced Failure Resistance.

Degree: 2021, Columbia University

URL: https://doi.org/10.7916/d8-rfmz-6x23

► The field of structural design optimization is one with great breadth and depth in many engineering applications. From the perspective of a designer, three distinct… (more)

▼ The field of structural design optimization is one with great breadth and depth in many engineering applications. From the perspective of a designer, three distinct numerical methodologies may be employed. These include size, shape, and topology optimization, in which the ordering typically (but not always) corresponds to the order of increasing complexity and computational expense. This, of course, depends on the particular problem of interest and the selected numerical methods. The primary focus of this research employs density-based topology optimization with the goal of improving structural resistance to failure. Beginning with brittle fracture, two topology optimization based formulations are proposed in which low weight designs are achieved with substantially increased fracture resistance. In contrast to the majority of the current relevant literature which favors stress constraints with linear elastic physics, we explicitly simulate brittle fracture using the phase field method during the topology optimization procedure. In the second formulation, a direct comparison is made against results obtained using conventional stress-constrained topology optimization and the improved performance is numerically demonstrated. Multiple enhancements are proposed including a numerical efficiency gain based on the Schur-complement during the analytical sensitivity analysis and a new function which provides additional path information to the optimizer, making the gradient-based optimization problem more tractable in the presence of brittle fracture physics. Subsequently, design for ductile failure and buckling resistance is addressed and a numerically efficient topology optimization formulation is proposed which may provide significant design improvements when ductile materials are used and extreme loading situations are anticipated. The proposed scheme is examined regarding its impact on both the peak load carrying capacity of the structure and the amount of external work required to achieve this peak load, past which the structure may no longer be able to support any increase in the external force. The optimized structures are also subjected to a post-optimization verification step in which a large deformation phase field fracture model is used to numerically compare the performance of each design. Significant gains in structural strength and toughness are demonstrated using the proposed framework. Additionally, the failure behavior of 3D-printed polymer composites is investigated, both numerically and experimentally. A large deformation phase field fracture model is derived under the assumption of plane-stress for numerical efficiency. Experimental results are compared to numerical simulations for a composite system consisting of three stiff circular inclusions embedded into a soft matrix. In particular, we examine how geometric parameters, such as the distances between inclusions and the length of initial notches affect the failure pattern in the soft composites. It is shown that the mechanical…

Subjects/Keywords: Biomedical engineering; Computer-aided design; Congenital heart disease; Heart valve prosthesis – Research; Stents (Surgery); Congenital heart disease in children – Surgery; Failure analysis (Engineering)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Russ, J. B. (2021). Computational Design of Structures for Enhanced Failure Resistance. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-rfmz-6x23

Chicago Manual of Style (16^th Edition):

Russ, Jonathan Brent. “Computational Design of Structures for Enhanced Failure Resistance.” 2021. Doctoral Dissertation, Columbia University. Accessed March 01, 2021. https://doi.org/10.7916/d8-rfmz-6x23.

MLA Handbook (7^th Edition):

Russ, Jonathan Brent. “Computational Design of Structures for Enhanced Failure Resistance.” 2021. Web. 01 Mar 2021.

Vancouver:

Russ JB. Computational Design of Structures for Enhanced Failure Resistance. [Internet] [Doctoral dissertation]. Columbia University; 2021. [cited 2021 Mar 01]. Available from: https://doi.org/10.7916/d8-rfmz-6x23.

Council of Science Editors:

Russ JB. Computational Design of Structures for Enhanced Failure Resistance. [Doctoral Dissertation]. Columbia University; 2021. Available from: https://doi.org/10.7916/d8-rfmz-6x23

22. Dimble, Dipesh S. Geometry modeling for patterned and repetitive configurations.

Degree: MS, 2006, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,28

►

Over the years, the use of computational engineering applications such as computer-aided design (CAD), computational fluid dynamics (CFD), and computational structural mechanics (CSM) has grown… (more)

▼

Over the years, the use of computational engineering applications such as computer-aided design (CAD), computational fluid dynamics (CFD), and computational structural mechanics (CSM) has grown rapidly in the aerospace, automotive, electronics, biomedical, and many other industries. Various software tools have emerged and evolved to meet the user’s demand for solving the complex physics associated with complex configurations in the processes of design, analysis, and optimization. The value of computational tools in product designs is obvious: They can provide reliable data for improving the design, reduce the design cycle and product validation process, and provide on effective and efficient means for assessing design performance characteristics, such as structural strength or fluid flow behaviors, that would otherwise require expensive and time-consuming physical experimentation. However, despite all the benefits provided by computational tools, it is still mostly a piecemeal process. All computer-based design tasks commence with the use of CAD systems to create detailed geometrical models. These models serve as a basis for diverse analysis tools, such as CFD and CSM, which would require another process called mesh generation to generate discrete spatial points for CFD and CSM tools to use in performing analyses. The accuracy of the analysis depends on the geometrical fidelity, the quality of the meshes, and the accuracy of the mathematical models. Any of these steps can often become a hurdle that requires tedious user interactions and parameter modifications. This thesis is an effort to address this issue, primarily by designing, modeling, and meshing complex patterned and repetitive geometries, such as springs or cardiac stents, using parametric geometry design and template mesh generation approaches. This can be done by developing modules in an integrated geometry and mesh generation software system called MiniCAD.

M.S.

ix, 62 p. : digital, PDF file, ill. (chiefly col.).

Mechanical Engineering

Engineering

UNRESTRICTED

Advisors/Committee Members: Shih, Alan M., Koomullil, Roy P. , Kim, Jong-Eun.

Subjects/Keywords: Computer graphics – Computer programs <; br>; Geometry – Computer programs <; br>; Numerical grid generation (Numerical analysis) – Computer programs <; br>; Stents (Surgery) – Computer-aided design

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dimble, D. S. (2006). Geometry modeling for patterned and repetitive configurations. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,28

Chicago Manual of Style (16^th Edition):

Dimble, Dipesh S. “Geometry modeling for patterned and repetitive configurations.” 2006. Masters Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,28.

MLA Handbook (7^th Edition):

Dimble, Dipesh S. “Geometry modeling for patterned and repetitive configurations.” 2006. Web. 01 Mar 2021.

Vancouver:

Dimble DS. Geometry modeling for patterned and repetitive configurations. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2006. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,28.

Council of Science Editors:

Dimble DS. Geometry modeling for patterned and repetitive configurations. [Masters Thesis]. University of Alabama – Birmingham; 2006. Available from: http://contentdm.mhsl.uab.edu/u?/etd,28

23. Halwani, Dina. Metal-tissue interactions in early stage biocorrosion of metallic stents.

Degree: MS, 2007, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,106

►

In-vivo corrosion of endovascular stents presents two main risks; release of toxic metallic ions and deterioration of the mechanical properties of the stents which may… (more)

▼

In-vivo corrosion of endovascular stents presents two main risks; release of toxic metallic ions and deterioration of the mechanical properties of the stents which may lead to fracture. Several studies have reported corrosion of nickel-titanium stent wires as well as stainless steel sternal wires. It has been suggested that when corrosion occurs on the surface of implants, an amount of metallic ions equivalent to the corroded volumes is released into surrounding tissue. The purpose of this study was to analyze explanted metallic stents for corrosion. The focus was on the detection of metallic ions released into surrounding vascular tissue as well as on alterations of the stent surface due to corrosion. The explanted specimens used in this study consisted of explanted stents surrounded by vascular tissue. Therefore, a standard protocol was developed in order to digest the vascular tissue for trace elemental spectrochemical analysis at parts per billion without compromising the stent surface. Scanning electron microscopy was used to examine the surfaces of explanted stents for evidence of corrosion in terms of surface alterations. The results were summarized as follows: (a) a standard tissue digestion protocol was successfully developed using a combination of low-impurity sodium hydroxide as the digestion medium, polypropylene containers for tissue storage during digestion, and ceramic cutting tools for sectioning of specimens; (b) the metallic levels detected in tissuesdissolved from explanted stents were significantly higher than the levels detected in controls; and (c) significant surface alterations due to biocorrosion and mechanical damage were observed on the surface of explanted stents whereas no surface alterations were observed on control stents.

M.S.

xii, 84 p. : ill. (some col.), facsims., digital, PDF file

Biomedical Engineering

Engineering

Stent corrosion Analysis of explanted stents

UNRESTRICTED

Advisors/Committee Members: Anayiotos, Andreas S., Anderson, Peter G. , Brott, Brigitta C. , Lemons, Jack E..

Subjects/Keywords: Stents (Surgery) – Materials – Biodegradation <; br>; Steel, Stainless – Biodegradation <; br>; Nickel-titanium alloys – Biodegradation <; br>; Scanning electron microscopy <; br>; X-ray spectroscopy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Halwani, D. (2007). Metal-tissue interactions in early stage biocorrosion of metallic stents. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,106

Chicago Manual of Style (16^th Edition):

Halwani, Dina. “Metal-tissue interactions in early stage biocorrosion of metallic stents.” 2007. Masters Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,106.

MLA Handbook (7^th Edition):

Halwani, Dina. “Metal-tissue interactions in early stage biocorrosion of metallic stents.” 2007. Web. 01 Mar 2021.

Vancouver:

Halwani D. Metal-tissue interactions in early stage biocorrosion of metallic stents. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2007. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,106.

Council of Science Editors:

Halwani D. Metal-tissue interactions in early stage biocorrosion of metallic stents. [Masters Thesis]. University of Alabama – Birmingham; 2007. Available from: http://contentdm.mhsl.uab.edu/u?/etd,106

24. Arauz Garofalo, Gianluca. Prospects of microwave spectrometry for vascular stent monitoring. Towards a non-invasive and non-ionizing follow-up alternative.

Degree: Departament de Física de la Matèria Condensada, 2017, Universitat de Barcelona

URL: http://hdl.handle.net/10803/404376

► Throughout this thesis we have assessed the prospects of microwave spectrometry (MWS) as a non-ionizing non-invasive monitoring alternative for stented patients in a very early… (more)

▼ Throughout this thesis we have assessed the prospects of microwave spectrometry (MWS) as a non-ionizing non-invasive monitoring alternative for stented patients in a very early proof-of-concept stage. In Chapter 1 we have provided a generalist retrospective medical background along with a state-of-the-art summary of existing microwave-based stent monitoring approaches. First, we have introduced cardiovascular diseases in general, and ischemic heart disease in particular. Next we have reviewed how percutaneous coronary interventions addressed the medical problem represented by atherosclerosis, giving a special emphasis to balloon angioplasty, bare-metal stenting and drug-eluting stenting. We have further exposed how the outcomes of such revolutionary strategies were compromised by the high rates of post-procedural complications, making unavoidable the invasive and ionizing follow-up of stented patients. Finally, we have summarized existing non-invasive and non-ionizing stent monitoring alternatives based in microwave techniques. In Chapter 2 we have introduced the working principle of our MWS setup. We have first presented how this arrangement can obtain the absorbance of a stent as a function of the frequency and the incidence angle of the microwave fields. We have also shown how these data are combined in a single two-dimensional chart, and how we recognize therein the characteristic resonance frequencies of stents at a glance. As an example, we have presented a typical absorbance diagram to illustrate the general features of such resonances. In particular we have highlighted that these resonances are discrete and have multi-lobed angular patterns. In Chapter 3 we have characterized many stents having a wide variety of nominal sizes to better understand their characteristic resonances in terms of microwave scattering. First, we have found that the resonance frequency obeys a reciprocal dependence on the stent length. This has allowed us to obtain an empirical expression for such relationship just by adjusting two fitting parameters. However, we have not been able to find an analogous expression for the dependence on the stent diameter. In any case, while investigating the latter, we have unexpectedly uncovered how the particular stent architecture influences the corresponding resonance frequencies. By gathering all these individual results we have finally suggested a straightforward half-theoretical half-empirical model linking the resonance frequencies of stents with their structural integrity (through their length), with their particular architecture (through the scaling factor), as well as with their surrounding medium (through the dielectric permittivity and the magnetic permeability). We have also theoretically estimated the resonance frequencies of implanted stents from their corresponding values in free space conditions, showing that in vivo resonance frequencies should be around one order of magnitude smaller than their free space counterparts. Finally, in Chapters 4 and 5 we have explored the potential… Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Tejada Palacios, Javier (director), García Santiago, Antoni (codirector), Franzese, Giancarlo (tutor), true (authorsendemail).

Subjects/Keywords: Espectrometria de masses; Espectrometría de masas; Mass spectrometry; Microones; Microondas; Microwaves; Pròtesis de Stent; Stents (Surgery); Stent; Aterosclerosi; Aterosclerosis; Atherosclerosis; Ciències Experimentals i Matemàtiques; 538.9

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APA (6^th Edition):

Arauz Garofalo, G. (2017). Prospects of microwave spectrometry for vascular stent monitoring. Towards a non-invasive and non-ionizing follow-up alternative. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/404376

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arauz Garofalo, Gianluca. “Prospects of microwave spectrometry for vascular stent monitoring. Towards a non-invasive and non-ionizing follow-up alternative.” 2017. Thesis, Universitat de Barcelona. Accessed March 01, 2021. http://hdl.handle.net/10803/404376.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arauz Garofalo, Gianluca. “Prospects of microwave spectrometry for vascular stent monitoring. Towards a non-invasive and non-ionizing follow-up alternative.” 2017. Web. 01 Mar 2021.

Vancouver:

Arauz Garofalo G. Prospects of microwave spectrometry for vascular stent monitoring. Towards a non-invasive and non-ionizing follow-up alternative. [Internet] [Thesis]. Universitat de Barcelona; 2017. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10803/404376.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arauz Garofalo G. Prospects of microwave spectrometry for vascular stent monitoring. Towards a non-invasive and non-ionizing follow-up alternative. [Thesis]. Universitat de Barcelona; 2017. Available from: http://hdl.handle.net/10803/404376

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Nelson, Terrilyn. Health-related Quality of Life One Year After Coronary Angioplasty and/or Coronary Stenting.

Degree: MS, Graduate Nursing, 1998, South Dakota State University

URL: https://openprairie.sdstate.edu/etd/872

► Cardiovascular diseases (CVD) afflict approximately 60 million Americans and are the leading causes of death in the United States. In 1995, more than 950,000… (more)

▼ Cardiovascular diseases (CVD) afflict approximately 60 million Americans and are the leading causes of death in the United States. In 1995, more than 950,000 deaths were attributed to CVD with coronary artery disease comprising 50% of the deaths (American Heart Association, 1997). Percutaneous transluminal coronary angioplasty (angioplasty) and coronary stenting (stenting) are common revascularization treatments for coronary artery disease. Advances in cardiovascular technology have resulted in noninvasive treatment strategies in order to decrease symptoms, improve myocardial oxygenation, and improve HRQOL. The problem under investigation in this study is to determine if there is a difference in HRQOL following angioplasty or stenting. Health-related quality of life (HRQOL) refers to how well a person functions in life compared to what the person perceives to be possible or optimal (Cella & Cherin, 1988; Stewart et al., 1992). Health-related quality of life was measured by the Short Form-36 (SF-36) and the Seattle Angina Questionnaire (SAQ). TheSF-36 consisted of 36 questions measuring general health; the subscales were: physical functioning, role functioning-physical, role functioning-emotional, social functioning, bodily pain, mental health, vitality, and general health perception. The SAQ consisted of 19 questions measuring specific concepts of CAD; the subscales measured were: physical functioning limitations, anginal stability, anginal frequency, treatment satisfaction, and disease perception. Cronbach's alpha for the SF-36 subscales ranged fi-om 0.73 to 0.91; while the Cronbach's alpha of the SAQ subscales ranged from 0.58 to 0.89. A descriptive, comparative design was used to: (a) describe and determine if there was a difference in HRQOL scores one year after either coronary angioplasty, coronary stenting, or a combination of both procedures; (b) determine the relationships among the subjects' characteristics and HRQOL scores following angioplasty and/or stenting; and (c) determine the relationships among the domains/subscales of the SF-36 and SAQ. Fifty eight people, from two Midwest health care agencies, consented to serve as subjects by returning completed questionnaires. The findings revealed that the sample was fairly representative for gender, age, racial/ethnic background, educational history, and employment status of the cardiovascular population undergoing angioplasty or stenting. The SF-36 and SAQ subscale (HRQOL) scores one year post angioplasty, stenting, or combination of both procedures were diminished when compared to the general population; but similar to persons with angina and with those persons three and six months post angioplasty. The mean SF-36 and SAQ subscale scores for the subjects in the angioplasty or stenting procedures were not significantly different. After adjusting the mean SF-36 and SAQ scores for the covariate, rated affects of comorbid conditions on HRQOL, women were significantly different than their male counterparts in the subscales of: physical functioning,… Advisors/Committee Members: Barbara Heater.

Subjects/Keywords: angioplasty; stents; coronary heart disease surgery patients; quality of life; Nursing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nelson, T. (1998). Health-related Quality of Life One Year After Coronary Angioplasty and/or Coronary Stenting. (Masters Thesis). South Dakota State University. Retrieved from https://openprairie.sdstate.edu/etd/872

Chicago Manual of Style (16^th Edition):

Nelson, Terrilyn. “Health-related Quality of Life One Year After Coronary Angioplasty and/or Coronary Stenting.” 1998. Masters Thesis, South Dakota State University. Accessed March 01, 2021. https://openprairie.sdstate.edu/etd/872.

MLA Handbook (7^th Edition):

Nelson, Terrilyn. “Health-related Quality of Life One Year After Coronary Angioplasty and/or Coronary Stenting.” 1998. Web. 01 Mar 2021.

Vancouver:

Nelson T. Health-related Quality of Life One Year After Coronary Angioplasty and/or Coronary Stenting. [Internet] [Masters thesis]. South Dakota State University; 1998. [cited 2021 Mar 01]. Available from: https://openprairie.sdstate.edu/etd/872.

Council of Science Editors:

Nelson T. Health-related Quality of Life One Year After Coronary Angioplasty and/or Coronary Stenting. [Masters Thesis]. South Dakota State University; 1998. Available from: https://openprairie.sdstate.edu/etd/872

26. Martinez, Adam W. Design and development of an elastin mimetic stent with therapeutic delivery potential.

Degree: PhD, Biomedical Engineering, 2011, Georgia Tech

URL: http://hdl.handle.net/1853/45926

► Stenting remains a common treatment option for atherosclerotic arteries. The main drawback of early stent platforms was restenosis, which has been combated by drug eluting… (more)

Subjects/Keywords: Rat stenting; Elastin miemtic; Laser fabrication; Crosslinking; Drug delivery; Stent; Stents (Surgery); Drug-eluting stents; Drug delivery devices; Implants, Artificial

…fluoroscopy with commercial stents above and below (C) EWlastin mimetic stent doped with… …which has been combated by drug eluting stents (DESs). The current limitation facing… …development of the next generation of DESs and first generation bioabsorbable stents to combat… …development of a new class of bioabsorbable stents composed of elastin mimetic protein polymers. The… …initial work focused on the ability to process these protein polymers into stents and ensure…

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APA (6^th Edition):

Martinez, A. W. (2011). Design and development of an elastin mimetic stent with therapeutic delivery potential. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/45926

Chicago Manual of Style (16^th Edition):

Martinez, Adam W. “Design and development of an elastin mimetic stent with therapeutic delivery potential.” 2011. Doctoral Dissertation, Georgia Tech. Accessed March 01, 2021. http://hdl.handle.net/1853/45926.

MLA Handbook (7^th Edition):

Martinez, Adam W. “Design and development of an elastin mimetic stent with therapeutic delivery potential.” 2011. Web. 01 Mar 2021.

Vancouver:

Martinez AW. Design and development of an elastin mimetic stent with therapeutic delivery potential. [Internet] [Doctoral dissertation]. Georgia Tech; 2011. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1853/45926.

Council of Science Editors:

Martinez AW. Design and development of an elastin mimetic stent with therapeutic delivery potential. [Doctoral Dissertation]. Georgia Tech; 2011. Available from: http://hdl.handle.net/1853/45926

University of Hong Kong

27. Wang, Yan. Atherosclerotic disease of the carotid, coronary and renal arteries: diagnosis, angioplasty and the effect ofstent surface on early thrombosis and restenosis.

Degree: 2004, University of Hong Kong

URL: http://hdl.handle.net/10722/56596

Subjects/Keywords: Stents (Surgery); Arteries - Stenosis.; Carotid artery - Diseases - Diagnosis.; Coronary heart disease - Diagnosis.; Renal artery - Diseases - Diagnosis.; Angioplasty.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2004). Atherosclerotic disease of the carotid, coronary and renal arteries: diagnosis, angioplasty and the effect ofstent surface on early thrombosis and restenosis. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/56596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yan. “Atherosclerotic disease of the carotid, coronary and renal arteries: diagnosis, angioplasty and the effect ofstent surface on early thrombosis and restenosis.” 2004. Thesis, University of Hong Kong. Accessed March 01, 2021. http://hdl.handle.net/10722/56596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yan. “Atherosclerotic disease of the carotid, coronary and renal arteries: diagnosis, angioplasty and the effect ofstent surface on early thrombosis and restenosis.” 2004. Web. 01 Mar 2021.

Vancouver:

Wang Y. Atherosclerotic disease of the carotid, coronary and renal arteries: diagnosis, angioplasty and the effect ofstent surface on early thrombosis and restenosis. [Internet] [Thesis]. University of Hong Kong; 2004. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10722/56596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. Atherosclerotic disease of the carotid, coronary and renal arteries: diagnosis, angioplasty and the effect ofstent surface on early thrombosis and restenosis. [Thesis]. University of Hong Kong; 2004. Available from: http://hdl.handle.net/10722/56596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Matsoukis, Ioannis. Συγκριτική μελέτη της κλινικής αποτελεσματικότητας επικαλυμμένων και μη επικαλυμμένων ενδοστεφανιαίων προθέσεων.

Degree: 2020, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/48085

► In this Thesis, long-term outcomes of 600 patients with chronic stable angina and an isolated de-novo lesion in the pLAD that underwent PCI with Endeavor-zotarolimus… (more)

▼ In this Thesis, long-term outcomes of 600 patients with chronic stable angina and an isolated de-novo lesion in the pLAD that underwent PCI with Endeavor-zotarolimus eluting stents (E-ZES) (Ν=180) and everolimus eluting stents (EES) (Ν=420) were compared. Mean clinical follow-up was 54,9 + 25,6 months. The study's primary endpoint was Target Lesion Failure (TLF), defined by its composites in hierarchical order: cardiac death, non-fatal MI not clearly attributed to a non-target vessel and clinically-driven revascularization of the target lesion (Target Lesion Revascularization - TLR). Secondary endpoints were Patient-Related Outcome (PRO – a composite index of all-cause mortality, any myocardial infarction related to any coronary artery, any revascularization conducted to any coronary artery), stent thrombosis and the components of TLF (cardiac death, non-fatal myocardial infarction and TLR). The use of EES in isolated de-novo pLAD lesions, led to substantially reduced clinical events in comparison to E-ZES. At 5 years, statistically significant differences between the two groups in the cumulative probability for TLF (13.8% for the E-ZES group versus 7.5% for the EES group, p=0.025) and for TLR (10% for the E-ZES group versus 3.3% for the EES group, p=0.003) were observed. No difference was observed concerning the remaining clinical outcomes. Differences between stents regarding TLF increased after 30 months. In multivariate analysis predictors of TLF adjusted for stent type were Diabetes mellitus and impaired estimated Glomerular Filtration Rate (eGFR).We also compared the long-term outcomes of PCI-DES and CABG with the left internal mammary artery in stable angina patients with isolated single-vessel pLAD disease. We included 631 PCI-DES patients and 379 CABG patients. The study’s primary endpoint was the occurrence of MACEs, namely, cardiac death, myocardial infarction not attributed to a non-target vessel and target lesion revascularization (using either the percutaneous or surgical technique) as a composite index. Secondary endpoints were Patient-Related Outcome, individual components of MACEs, recurrence of stable or unstable angina or a nonfatal arrhythmia (atrial fibrillation, atrial flutter or nonsustained ventricular tachycardia), duration of hospitalization, any complication (periprocedural or in-hospital) and CAD progression of other lesions (namely, nontarget vessel myocardial infarction, new onset of a nontarget vessel/lesion attributed stable angina determined by cardiac scintigraphy stress-test and/or angiography). Unadjusted and adjusted hazard ratios (HRs) were derived for all main outcomes. The main finding of the comparison was that long-term MACE rates were comparable between the two groups, despite a borderline significantly lower risk of repeat revascularization in the CABG group than in the PCI group. Moreover, no significant difference was observed between the two cohorts with respect to the risk of MACEs, PRO, cardiac death and nonfatal myocardial infarction. Compared with CABG, PCI-DES had a…

Subjects/Keywords: Ενδοστεφανιαίες προθέσεις κεκαλυμμένες με φαρμακευτικές ουσίες; Στεφανιαίες ενδοπροθέσεις; Επεμβάσεις αορτοστεφανιαίας παράκαμψης; Κλινική αποτελεσματικότητα; Αγγειοπλαστική στεφανιαίων αγγείων; Στεφανιαία νόσος; Coronary artery bypass graft surgery; Coronary artery disease; Percutaneous coronary intervention; Coronary stent; Drug eluting stents (DES); Clinical effectiveness

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matsoukis, I. (2020). Συγκριτική μελέτη της κλινικής αποτελεσματικότητας επικαλυμμένων και μη επικαλυμμένων ενδοστεφανιαίων προθέσεων. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/48085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matsoukis, Ioannis. “Συγκριτική μελέτη της κλινικής αποτελεσματικότητας επικαλυμμένων και μη επικαλυμμένων ενδοστεφανιαίων προθέσεων.” 2020. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/48085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matsoukis, Ioannis. “Συγκριτική μελέτη της κλινικής αποτελεσματικότητας επικαλυμμένων και μη επικαλυμμένων ενδοστεφανιαίων προθέσεων.” 2020. Web. 01 Mar 2021.

Vancouver:

Matsoukis I. Συγκριτική μελέτη της κλινικής αποτελεσματικότητας επικαλυμμένων και μη επικαλυμμένων ενδοστεφανιαίων προθέσεων. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/48085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matsoukis I. Συγκριτική μελέτη της κλινικής αποτελεσματικότητας επικαλυμμένων και μη επικαλυμμένων ενδοστεφανιαίων προθέσεων. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. Available from: http://hdl.handle.net/10442/hedi/48085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

29. Rose, Stacey Loren. In Vitro Model of Vascular Healing in the Presence of Biomaterials.

Degree: PhD, Biomedical Engineering, 2006, Georgia Tech

URL: http://hdl.handle.net/1853/13955

► Coronary artery stent placement has been a significant advance in the percutaneous treatment of atherosclerotic disease, and tissue engineered vascular grafts may provide a viable… (more)

▼ Coronary artery stent placement has been a significant advance in the percutaneous treatment of atherosclerotic disease, and tissue engineered vascular grafts may provide a viable alternative to autologous segments for small diameter vessels. However, in-stent restenosis remains an important limitation, and tissue engineered grafts have poor patency and high risk of thrombus formation due to their inability to maintain a confluent, adherent, and quiescent endothelium. While animal models provide insight into the pathophysiology of these situations, elucidation of the relative importance of stent or graft components, hemodynamic factors, and molecular factors is difficult. Very little research has focused on bridging gaps in knowledge concerning blood/biomaterial interactions, blood/endothelial cell interactions, and endothelial cell/smooth muscle cell cross-talk. The work presented within this thesis will do just that. The objective of this thesis research was to elucidate the influence of biomaterial-induced activation of leukocytes on endothelial cell or smooth muscle cell phenotype, as well as endothelial cell/smooth muscle cell cross-talk in co-culture systems. Towards this goal, two complimentary in vitro endothelial cell/smooth muscle cell co-culture models with divergent smooth muscle cell phenotype were developed and characterized. Using these systems, it was found that the presence of more secretory smooth muscle cells (as would be seen in wound healing or disease) in general enhanced endothelial cell activation in response to biomaterial-pretreated monocytes, while the presence of less secretory smooth muscle cells (to model more quiescent smooth muscle cells found in uninjured healthy vessels) suppressed endothelial cell activation in response to biomaterial-pretreated monocytes (and neutrophils to a small degree). Additionally, biomaterial-pretreated monocytes and neutrophils amplified a smooth muscle cell phenotypic shift away from a more quiescent state. It is likely that the compounding effect of secretory smooth muscle cells and biomaterial-activated leukocytes are responsible for altered vascular wound healing upon implantation of stents or vascular grafts. Understanding the specific signals causing these effects, or signals delivered by contractile smooth muscle cells that limit these effects help to provide design criteria for development of devices or grafts capable of long term patency. Advisors/Committee Members: Dr. Julia Babensee (Committee Chair), Dr. Elliot Chaikof (Committee Member), Dr. Hanjoong Jo (Committee Member), Dr. Michael Sefton (Committee Member), Dr. Robert Nerem (Committee Member), Dr. Suzanne Eskin (Committee Member).

Subjects/Keywords: Biomaterials; Leukocytes; Smooth muscle cells; Endothelial cells; Stents (Surgery); Vascular endothelial growth factors; Biocompatibility; Leucocytes; Regeneration (Biology)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rose, S. L. (2006). In Vitro Model of Vascular Healing in the Presence of Biomaterials. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/13955

Chicago Manual of Style (16^th Edition):

Rose, Stacey Loren. “In Vitro Model of Vascular Healing in the Presence of Biomaterials.” 2006. Doctoral Dissertation, Georgia Tech. Accessed March 01, 2021. http://hdl.handle.net/1853/13955.

MLA Handbook (7^th Edition):

Rose, Stacey Loren. “In Vitro Model of Vascular Healing in the Presence of Biomaterials.” 2006. Web. 01 Mar 2021.

Vancouver:

Rose SL. In Vitro Model of Vascular Healing in the Presence of Biomaterials. [Internet] [Doctoral dissertation]. Georgia Tech; 2006. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1853/13955.

Council of Science Editors:

Rose SL. In Vitro Model of Vascular Healing in the Presence of Biomaterials. [Doctoral Dissertation]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/13955

30. Andukuri, Adinarayana. A Bioinspired Multifunctional Nanomatrix For Cardiovascular Applications.

Degree: 2013, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1481

►

Bioinspired solutions for challenges faced by conventional therapies are rapidly emerging, especially as new and innovative improvements in medical devices are constantly being researched and… (more)

▼

Bioinspired solutions for challenges faced by conventional therapies are rapidly emerging, especially as new and innovative improvements in medical devices are constantly being researched and developed. Stents are a common therapeutic device for cardiovascular diseases that have undergone incrementally developmental changes over the last two decades. However, there are concerns about in-stent restenosis with bare metal stents and incomplete endothelialization, late stent thrombosis, and late inflammatory responses with drug-eluting stents. New strategies for stents include the development of bioresorbable stents and the utilization of endothelial progenitor cell capture techniques. Despite the promise of recent developments aimed at overcoming the limitations of current stents, concerns still remain and success is limited. It is critical to develop an innovative strategy to overcome these limitations. Hence, the goal of this dissertation is to develop a bioinspired strategy for a multifunctional self-assembled peptide amphiphile (PA) nanomatrix coating that can provide characteristic properties of the native endothelium on the surface of stents. The PAs used in the study to develop an endothelium mimicking stent coating comprise endothelial cell adhesive ligands, nitric oxide donors, enzyme mediated degradable sites, and water based self-assembly into a nanofibrous matrix. Incorporation of these features endows the nanomatrix with the ability to closely mimic the native endothelium. It is hypothesized that this bioinspired multifunctional nanomatrix promotes endothelialization, but limits neointimal hyperplasia, restenosis, thrombosis, and inflammatory reactions. Preliminary studies have successfully demonstrated the feasibility of the bioinspired multifunctional nanomatrix. Successful self-assembly into nanofibers and long term release of nitric oxide was achieved. The bioinspired nanomatrix promotes endothelial proliferation, but limits smooth muscle cell proliferation and platelet adhesion. It also promoted the adhesion and differentiation of endothelial progenitor cells. This bioinspired multifunctional nanomatrix coating has the potential to overcome current challenges of stents and further be applied to various cardiovascular implants.

PhD

1 online resource (x, 161 pages) :illustrations (some color)

Biomedical Engineering

Biomimetic, Nitric oxide, Peptide amphiphile, Stents

UNRESTRICTED

Advisors/Committee Members: Ho-Wook Jun, Brott, Brigitta C. Dean, Derrick R. Middleton, John C. Yoon,Young-Sup Berry, Joel L..

Subjects/Keywords: Stents (Surgery) – Biocompatibility.<; br>; Coatings – Biocompatibility.<; br>; Endothelium.<; br>; Peptide amphiphiles – Formation.<; br>; Vascular endothelium – Regeneration – Equipment and supplies – Design and construction.<; br>; Nanostructured materials.<; br>; Biomedical materials.

…Nanomatrix Coatings for Stents ................14 EFFECT OF ENDOTHELIUM MIMICKING SELF-ASSEMBLED… …130 x 1 INTRODUCTION Stents are the most commonly implanted devices used in the… …inflated. Bare metal stents (BMS) deployment has reduced the rate of re-narrowing… …restenosis caused by inevitable endothelial injury1. Drug-eluting stents (DES) have… …stents have been developed which may also reduce late stent thrombosis6-11. Another new…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Andukuri, A. (2013). A Bioinspired Multifunctional Nanomatrix For Cardiovascular Applications. (Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1481

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Andukuri, Adinarayana. “A Bioinspired Multifunctional Nanomatrix For Cardiovascular Applications.” 2013. Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,1481.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Andukuri, Adinarayana. “A Bioinspired Multifunctional Nanomatrix For Cardiovascular Applications.” 2013. Web. 01 Mar 2021.

Vancouver:

Andukuri A. A Bioinspired Multifunctional Nanomatrix For Cardiovascular Applications. [Internet] [Thesis]. University of Alabama – Birmingham; 2013. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1481.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Andukuri A. A Bioinspired Multifunctional Nanomatrix For Cardiovascular Applications. [Thesis]. University of Alabama – Birmingham; 2013. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1481

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations