subject:(Stenosis)

1. Jain, Lovely. Modelling and analysis of blood flow in an artery having mild stenosis with and without bypass: effects of blood and wall characteristics.

Degree: Mathematics, 2014, INFLIBNET

URL: http://shodhganga.inflibnet.ac.in/handle/10603/14562

►

Severe stenosis may cause critical flow conditions related to artery collapse, plaque cap rupture which leads directly to stroke and heart attack. Stroke and ischemic… (more)

Subjects/Keywords: Mathematics; Stenosis

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APA (6^th Edition):

Jain, L. (2014). Modelling and analysis of blood flow in an artery having mild stenosis with and without bypass: effects of blood and wall characteristics. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/14562

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jain, Lovely. “Modelling and analysis of blood flow in an artery having mild stenosis with and without bypass: effects of blood and wall characteristics.” 2014. Thesis, INFLIBNET. Accessed March 07, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/14562.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jain, Lovely. “Modelling and analysis of blood flow in an artery having mild stenosis with and without bypass: effects of blood and wall characteristics.” 2014. Web. 07 Mar 2021.

Vancouver:

Jain L. Modelling and analysis of blood flow in an artery having mild stenosis with and without bypass: effects of blood and wall characteristics. [Internet] [Thesis]. INFLIBNET; 2014. [cited 2021 Mar 07]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/14562.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jain L. Modelling and analysis of blood flow in an artery having mild stenosis with and without bypass: effects of blood and wall characteristics. [Thesis]. INFLIBNET; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/14562

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Catholique de Louvain

2. Maes, Frédéric. Paradoxical low-gradient aortic stenosis : characterization and natural history of a complex and heterogeneous entity.

Degree: 2017, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/192589

►

Calcific aortic stenosis is the most prevalent heart valve disorder in developed countries with aortic valve replacement remaining the only effective treatment. Diagnosis and staging… (more)

Subjects/Keywords: Aortic Stenosis

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APA (6^th Edition):

Maes, F. (2017). Paradoxical low-gradient aortic stenosis : characterization and natural history of a complex and heterogeneous entity. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/192589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maes, Frédéric. “Paradoxical low-gradient aortic stenosis : characterization and natural history of a complex and heterogeneous entity.” 2017. Thesis, Université Catholique de Louvain. Accessed March 07, 2021. http://hdl.handle.net/2078.1/192589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maes, Frédéric. “Paradoxical low-gradient aortic stenosis : characterization and natural history of a complex and heterogeneous entity.” 2017. Web. 07 Mar 2021.

Vancouver:

Maes F. Paradoxical low-gradient aortic stenosis : characterization and natural history of a complex and heterogeneous entity. [Internet] [Thesis]. Université Catholique de Louvain; 2017. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2078.1/192589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maes F. Paradoxical low-gradient aortic stenosis : characterization and natural history of a complex and heterogeneous entity. [Thesis]. Université Catholique de Louvain; 2017. Available from: http://hdl.handle.net/2078.1/192589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Loughborough University

3. Jackson, Mark. The development and applications of a system designed to quantify coronary arterial stenosis.

Degree: PhD, 1988, Loughborough University

URL: https://doi.org/10.26174/thesis.lboro.11764275.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799164

► The objective analysis of coronary artery stenosis is required for the assessment of interventions in the management of Coronary Artery Disease (CAD). This thesis presents… (more)

Subjects/Keywords: Stenosis

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APA (6^th Edition):

Jackson, M. (1988). The development and applications of a system designed to quantify coronary arterial stenosis. (Doctoral Dissertation). Loughborough University. Retrieved from https://doi.org/10.26174/thesis.lboro.11764275.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799164

Chicago Manual of Style (16^th Edition):

Jackson, Mark. “The development and applications of a system designed to quantify coronary arterial stenosis.” 1988. Doctoral Dissertation, Loughborough University. Accessed March 07, 2021. https://doi.org/10.26174/thesis.lboro.11764275.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799164.

MLA Handbook (7^th Edition):

Jackson, Mark. “The development and applications of a system designed to quantify coronary arterial stenosis.” 1988. Web. 07 Mar 2021.

Vancouver:

Jackson M. The development and applications of a system designed to quantify coronary arterial stenosis. [Internet] [Doctoral dissertation]. Loughborough University; 1988. [cited 2021 Mar 07]. Available from: https://doi.org/10.26174/thesis.lboro.11764275.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799164.

Council of Science Editors:

Jackson M. The development and applications of a system designed to quantify coronary arterial stenosis. [Doctoral Dissertation]. Loughborough University; 1988. Available from: https://doi.org/10.26174/thesis.lboro.11764275.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799164

4. Apostolidou, Eirini. Association between red blood cell transfusion morbidity, mortality and thirty-day readmission in patients undergoing transcatheter aortic valve replacement.

Degree: School of Public Health, 2018, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:792711/

► Abstract of “Association between red blood cell transfusion and clinical outcomes among patients undergoing transcatheter aortic valve replacement” by Eirini Apostolidou, MD, Brown University, May… (more)

▼ Abstract of “Association between red blood cell transfusion and clinical outcomes among patients undergoing transcatheter aortic valve replacement” by Eirini Apostolidou, MD, Brown University, May 2018 Objectives: We sought to evaluate the association between post-procedural packed red blood cell (PRBC) transfusion and morbidity and mortality in patients undergoing transcatheter aortic valve replacement (TAVR) for severe symptomatic aortic stenosis. Background: There is increasing evidence that PRBC transfusion in patients undergoing cardiac surgical procedures is associated with adverse outcome. While the association between pre-procedure anemia, procedure-related bleeding, vascular complications and survival is well described, little is known about the independent relationship between post-TAVR PRBC transfusion and clinical outcome. Methods: We retrospectively analyzed 429 consecutive patients with severe aortic stenosis, who underwent TAVR between March 2012 and December 2017, at a single institution. Propensity-score adjusted multivariable logistic and Cox regression models were used to determine the association between PRBC transfusion and the composite endpoint of death, myocardial infarction (MI) or stroke at 30-days and in-hospital, as well as 1-year mortality. Results: Among our study population, 25.2% of patients received PRBC transfusion. In the transfusion group, 63.9% received up to 2 units of PRBC and 77.8% of transfused patients received blood within the first 12 hours post-operatively. Patients who received transfusion were more often female gender (55.6 % vs. 44.5%, p=0.047); had a lower BMI (25± 5.8 vs. 28.7± 9.8, p=0.001) and a higher prevalence of peripheral artery disease (32. 4% vs. 22.1 %, p=0.031). Transfused patients had a significantly higher 30-day incidence of death, MI or stroke when compared to patients who did not receive transfusion (HR: 2.03; 95% CI: 1.02, 4.07; p=0.045). Similarly, the composite outcome of in-hospital death/MI/stroke was higher in the transfusion group (HR: 2.46; 95% CI: 1.12, 5.41; p=0.025). Post-procedural transfusion independently predicted mortality at 1-year as well (HR: 2.65; 95% CI: 1.21, 5.80, p=0.015). Conclusions: PRBC transfusion in patients undergoing TAVR is associated with an increased incidence of adverse outcomes in-hospital, at 30 days and at 1 year. Randomized data are needed to determine whether a restrictive transfusion strategy is preferable in this setting. Advisors/Committee Members: Aronow, Herbert (Advisor).

Subjects/Keywords: Aortic valve – Stenosis

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APA (6^th Edition):

Apostolidou, E. (2018). Association between red blood cell transfusion morbidity, mortality and thirty-day readmission in patients undergoing transcatheter aortic valve replacement. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792711/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Apostolidou, Eirini. “Association between red blood cell transfusion morbidity, mortality and thirty-day readmission in patients undergoing transcatheter aortic valve replacement.” 2018. Thesis, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:792711/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Apostolidou, Eirini. “Association between red blood cell transfusion morbidity, mortality and thirty-day readmission in patients undergoing transcatheter aortic valve replacement.” 2018. Web. 07 Mar 2021.

Vancouver:

Apostolidou E. Association between red blood cell transfusion morbidity, mortality and thirty-day readmission in patients undergoing transcatheter aortic valve replacement. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:792711/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Apostolidou E. Association between red blood cell transfusion morbidity, mortality and thirty-day readmission in patients undergoing transcatheter aortic valve replacement. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792711/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

5. Piskolti, Péter. Croup-syndroma és felső légúti stenosisok oxyologiája csecsemő- és gyermekkorban .

Degree: DE – Egészségügyi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/190752

Dolgozatomban Croup-syndroma és felső légúti stenosisok oxyologiáját mutatom be csecsemő- és gyermekkorban. Advisors/Committee Members: Dicső, Ferenc (advisor).

Subjects/Keywords: felső légúti stenosis

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APA (6^th Edition):

Piskolti, P. (2014). Croup-syndroma és felső légúti stenosisok oxyologiája csecsemő- és gyermekkorban . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/190752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Piskolti, Péter. “Croup-syndroma és felső légúti stenosisok oxyologiája csecsemő- és gyermekkorban .” 2014. Thesis, University of Debrecen. Accessed March 07, 2021. http://hdl.handle.net/2437/190752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Piskolti, Péter. “Croup-syndroma és felső légúti stenosisok oxyologiája csecsemő- és gyermekkorban .” 2014. Web. 07 Mar 2021.

Vancouver:

Piskolti P. Croup-syndroma és felső légúti stenosisok oxyologiája csecsemő- és gyermekkorban . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2437/190752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Piskolti P. Croup-syndroma és felső légúti stenosisok oxyologiája csecsemő- és gyermekkorban . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/190752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

6. Montemarano, Michael Anthony. The success rates of surgical and non- surgical approaches in the management and treatment of spinal stenosis.

Degree: MS, Medical Sciences, 2015, Boston University

URL: http://hdl.handle.net/2144/16017

► This thesis presents a literature review of the diagnosis and treatment of lumbar spinal stenosis (LSS), including a brief description of the patient history and… (more)

Subjects/Keywords: Surgery; LS; Neurosurgery; Orthopedics; Stenosis; Spinal stenosis; Stenosis review

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APA (6^th Edition):

Montemarano, M. A. (2015). The success rates of surgical and non- surgical approaches in the management and treatment of spinal stenosis. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16017

Chicago Manual of Style (16^th Edition):

Montemarano, Michael Anthony. “The success rates of surgical and non- surgical approaches in the management and treatment of spinal stenosis.” 2015. Masters Thesis, Boston University. Accessed March 07, 2021. http://hdl.handle.net/2144/16017.

MLA Handbook (7^th Edition):

Montemarano, Michael Anthony. “The success rates of surgical and non- surgical approaches in the management and treatment of spinal stenosis.” 2015. Web. 07 Mar 2021.

Vancouver:

Montemarano MA. The success rates of surgical and non- surgical approaches in the management and treatment of spinal stenosis. [Internet] [Masters thesis]. Boston University; 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2144/16017.

Council of Science Editors:

Montemarano MA. The success rates of surgical and non- surgical approaches in the management and treatment of spinal stenosis. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/16017

University of Utah

7. Vickers, Daniel Baker. Hyperthermia for treatment of hyperplasia in a hemodialysis access graft.

Degree: MS;, Bioengineering;, 2008, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598

► I would like to express my appreciation to my supervisory committee. Committee chair Dr. Douglas Christensen provided the knowledge and expertise to make this all… (more)

Subjects/Keywords: Vascular grafts; Hemodialysis; Stenosis; Hyperplasia

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APA (6^th Edition):

Vickers, D. B. (2008). Hyperthermia for treatment of hyperplasia in a hemodialysis access graft. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598

Chicago Manual of Style (16^th Edition):

Vickers, Daniel Baker. “Hyperthermia for treatment of hyperplasia in a hemodialysis access graft.” 2008. Masters Thesis, University of Utah. Accessed March 07, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598.

MLA Handbook (7^th Edition):

Vickers, Daniel Baker. “Hyperthermia for treatment of hyperplasia in a hemodialysis access graft.” 2008. Web. 07 Mar 2021.

Vancouver:

Vickers DB. Hyperthermia for treatment of hyperplasia in a hemodialysis access graft. [Internet] [Masters thesis]. University of Utah; 2008. [cited 2021 Mar 07]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598.

Council of Science Editors:

Vickers DB. Hyperthermia for treatment of hyperplasia in a hemodialysis access graft. [Masters Thesis]. University of Utah; 2008. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598

Penn State University

8. Greenleaf, Erin M. Carotid endarterectomy versus carotid artery stenting: comparing health care utilization in patients with carotid stenosis.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/28653

► In the United States, ischemic stroke is a major cause of morbidity and mortality, precipitated by carotid artery stenosis in one out of every five… (more)

▼ In the United States, ischemic stroke is a major cause of morbidity and mortality, precipitated by carotid artery stenosis in one out of every five individuals who suffer a stroke. Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are two proven means of intervening on this disease process, with similar patient outcomes. Little is known about the burden of readmission following each of these procedures. We hypothesized that no difference in readmission rates within 30 days or length of stay (LOS) would exist for these two procedures, in spite of baseline differences that might exist between the two patient populations. Using the Pennsylvania Health Care Cost Containment Council (PHC4) database, we identified 4,319 people who underwent CEA (N=3,640) or CAS (N=679) in Pennsylvania in 2011. Univariate analyses were performed to compare patient characteristics and outcomes, including reasons for readmission, between patients who underwent CEA and those who underwent CAS. Logistic regression was used to estimate the effect of intervention on 30-day readmission, after controlling for potential confounders. Linear regression was used to estimate the effect of intervention on LOS. Time to readmission was analyzed using the Kaplan-Meier method. Patients who underwent CEA and CAS differed in a few notable ways, including age, race, admission type, and comorbid conditions such as CHF, hemiplegia and paraplegia, and renal disease. The unadjusted rate of 30-day readmission was 9.37% for CEA and 10.75% for CAS (P=0.26). After controlling for patient and procedure characteristics, differences between 30-day readmission rates were still not statistically significant (odds ratio=1.13; P=0.39), although CAS was associated with a statistically significant shorter LOS (-0.30; P<0.0001). Finally, time to readmission was similar for those who underwent CEA and those who underwent CAS (P=0.19). Complications associated with surgery comprised less than 10% of primary readmission diagnoses for both groups. Readmission rates following CEA and CAS for carotid artery stenosis are approximately 10%. In spite of differences between patients with carotid stenosis who are selected for endarterectomy and stenting, the choice of procedure does not appear to be associated with different readmission rates or time to readmission, although a marginally shorter LOS after CAS, after controlling for patient characteristics. Advisors/Committee Members: Christopher Hollenbeak, Thesis Advisor/Co-Advisor, Douglas L Leslie, Thesis Advisor/Co-Advisor, Kristen H Kjerulff, Thesis Advisor/Co-Advisor.

Subjects/Keywords: carotid artery stenosis; endarterectomy; stenting

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APA (6^th Edition):

Greenleaf, E. M. (2016). Carotid endarterectomy versus carotid artery stenting: comparing health care utilization in patients with carotid stenosis. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/28653

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Greenleaf, Erin M. “Carotid endarterectomy versus carotid artery stenting: comparing health care utilization in patients with carotid stenosis.” 2016. Thesis, Penn State University. Accessed March 07, 2021. https://submit-etda.libraries.psu.edu/catalog/28653.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Greenleaf, Erin M. “Carotid endarterectomy versus carotid artery stenting: comparing health care utilization in patients with carotid stenosis.” 2016. Web. 07 Mar 2021.

Vancouver:

Greenleaf EM. Carotid endarterectomy versus carotid artery stenting: comparing health care utilization in patients with carotid stenosis. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Mar 07]. Available from: https://submit-etda.libraries.psu.edu/catalog/28653.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Greenleaf EM. Carotid endarterectomy versus carotid artery stenting: comparing health care utilization in patients with carotid stenosis. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/28653

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

9. Mack, William Jacob. Particulate matter from vehicular exhaust in the setting of chronic cerebral hypoperfusion.

Degree: MS, Clinical, Biomedical and Translational Investigations, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343212/rec/4942

► The proposed research program seeks to determine the impact of particulate matter (PM) exposure on white matter injury and neurocognitive decline. These associations are further… (more)

▼ The proposed research program seeks to determine the impact of particulate matter (PM) exposure on white matter injury and neurocognitive decline. These associations are further examined in the setting of underlying cerebrovascular disease (chronic cerebral hypoperfusion). Studies have established a strong relationship between PM exposure and atherosclerotic cardiovascular disease. Clinical imaging, epidemiology and pharmacotherapy studies have verified a critical role for cerebral vascular dysfunction in the onset and progression of dementia and cognitive deficits. Investigations suggest a relationship between long-term PM exposure and low cognitive performance, however, very little is known about underlying pathophysiology or putative mechanisms. Our preliminary experimental data suggests an association between PM exposure and white matter injury in the corpus callosum of mice. Cerebrovascular disease may affect this process. Experimental studies examining the effects of air pollution in the setting of cerebrovascular disease are lacking. The proposed investigation utilizes an experimental murine model to address theses knowledge gaps through the following specific aims: 1) To examine the time course of white matter injury secondary to PM exposure. 2) To examine the effects of PM exposure and chronic cerebral hypoperfusion (CCH) on white matter injury and neurocognition and, 3) To examine the impact of PM exposure and CCH on inflammation, oxidative stress and BBB permeability. Urban PM will be collected with a particle sampler situated near the CA 110 Freeway in Los Angeles. Collected aerosols represent a mix of fresh PM, predominantly from vehicular traffic. These samples will then be distilled to nanoparticles and re-aerosolized for administration to mice through exposure chambers. The principal investigator has refined a Bilateral Carotid Stenosis model of CCH which generates reproducible white matter injury and behavioral deficits. A factorial design will be used to assess the independent and combined effects of PM exposure and CCH on white matter injury and neurocognitive decline. When administered together, we expect these exposures to exhibit synergy. Putative mechanisms of injury including inflammation, oxidative stress and blood-brain barrier breakdown, will be examined. The proposed research program utilizes nanoparticulate matter exposures sampled from a near-roadway traffic source, representing real world, multi-pollutant exposures. Scientific knowledge obtained from this study will advance our understanding of the relationship between PM exposure and white matter injury and neurocognitive decline. Insight into the role of underlying cerebrovascular disease will be gained. Results could ultimately impact public policies and regulation with respect to cognitive health in a vulnerable population and provide a critical first step towards individual risk assessment and stratification. Advisors/Committee Members: Zlokovic, Berislav V. (Committee Chair), Samet, Jonathan M. (Committee Member), Mack, Wendy Jean (Committee Member).

Subjects/Keywords: particulate; cerebral; hypoperfusion; stenosis

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APA (6^th Edition):

Mack, W. J. (2015). Particulate matter from vehicular exhaust in the setting of chronic cerebral hypoperfusion. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343212/rec/4942

Chicago Manual of Style (16^th Edition):

Mack, William Jacob. “Particulate matter from vehicular exhaust in the setting of chronic cerebral hypoperfusion.” 2015. Masters Thesis, University of Southern California. Accessed March 07, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343212/rec/4942.

MLA Handbook (7^th Edition):

Mack, William Jacob. “Particulate matter from vehicular exhaust in the setting of chronic cerebral hypoperfusion.” 2015. Web. 07 Mar 2021.

Vancouver:

Mack WJ. Particulate matter from vehicular exhaust in the setting of chronic cerebral hypoperfusion. [Internet] [Masters thesis]. University of Southern California; 2015. [cited 2021 Mar 07]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343212/rec/4942.

Council of Science Editors:

Mack WJ. Particulate matter from vehicular exhaust in the setting of chronic cerebral hypoperfusion. [Masters Thesis]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343212/rec/4942

Brigham Young University

10. Hilton, Benjamin Allen. The Effect of Subglottic Stenosis on the Aerodynamic, Acoustical, and Vibratory Output of Synthetic Vocal Fold Models.

Degree: MS, 2019, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8595&context=etd

► There are many conditions and diseases that affect voice production. One of these, subglottic stenosis (SGS), is characterized by a narrowing of the trachea… (more)

▼ There are many conditions and diseases that affect voice production. One of these, subglottic stenosis (SGS), is characterized by a narrowing of the trachea near the cricotracheal junction. SGS causes dyspnea (labored breathing) and frequently surgery is necessary to eliminate the airway obstruction. SGS is also believed to adversely affect voice quality. While significant research has been conducted to study the effect of SGS on breathing, relatively few studies concerning its effect on voice production have been performed. The purpose of this research was to provide quantitative results concerning the predicted effects of SGS on vocal fold (VF) vibration and resulting sound production, and to provide tools for more extensive research involving synthetic VF models in the future. This was achieved through an experimental procedure in which a device simulating SGS was coupled with synthetic VF models and acoustic, aerodynamic, and vibratory measurements were acquired. Additionally, a device was developed and tested to study the effects of VF posturing using synthetic VF models. The design of the device is anticipated to serve as a useful tool in future experiments.The device simulating SGS was capable of creating an artificial stenosis of adjustable severity. The device was designed so that synthetic VF models inserted into rigid plates could be placed on top of the device, downstream of the stenosis. An experiment was conducted with the SGS device in conjunction with synthetic four-layer VF models in which flow and pressure were measured, radiated sound data were recorded, and visual data from a high-speed camera were captured as the percent obstruction was changed. The effects of subglottic stenosis were quantified using metrics such as onset pressure, glottal area, smoothed cepstral peak prominence (CPPS), harmonic-to-noise ratio (HNR), acoustic spectra, air flow, and pressure below and above the stenosis. The results show that the glottal area was not noticeably affected by the stenosis until 80% or 90% obstruction, and flow resistance through the stenosis was not significantly affected until 85% obstruction. However, changes in acoustics occurred as low as 65% or 70% obstruction.An MRI-compatible posturing device was developed which was capable of causing abduction/adduction and elongation in synthetic VF models. The device was used to adduct synthetic VF models from an abducted position into a pre-determined final phonatory posture as high-speed video and pressure data were collected. The device adducted to final phonatory posture in 500 ms, and phonation was initiated 680 ms later. In addition, the elongation of the synthetic models was varied as high-speed data were collected. The frequency of vibration of the four-layer models was found to not vary significantly when the models were elongated.

Subjects/Keywords: synthetic vocal fold; subglottic stenosis; stenosis; vocal fold posturing; MRI; Engineering

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APA (6^th Edition):

Hilton, B. A. (2019). The Effect of Subglottic Stenosis on the Aerodynamic, Acoustical, and Vibratory Output of Synthetic Vocal Fold Models. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8595&context=etd

Chicago Manual of Style (16^th Edition):

Hilton, Benjamin Allen. “The Effect of Subglottic Stenosis on the Aerodynamic, Acoustical, and Vibratory Output of Synthetic Vocal Fold Models.” 2019. Masters Thesis, Brigham Young University. Accessed March 07, 2021. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8595&context=etd.

MLA Handbook (7^th Edition):

Hilton, Benjamin Allen. “The Effect of Subglottic Stenosis on the Aerodynamic, Acoustical, and Vibratory Output of Synthetic Vocal Fold Models.” 2019. Web. 07 Mar 2021.

Vancouver:

Hilton BA. The Effect of Subglottic Stenosis on the Aerodynamic, Acoustical, and Vibratory Output of Synthetic Vocal Fold Models. [Internet] [Masters thesis]. Brigham Young University; 2019. [cited 2021 Mar 07]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8595&context=etd.

Council of Science Editors:

Hilton BA. The Effect of Subglottic Stenosis on the Aerodynamic, Acoustical, and Vibratory Output of Synthetic Vocal Fold Models. [Masters Thesis]. Brigham Young University; 2019. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8595&context=etd

11. Bean, Jim. Acquired subglottic stenosis : an experimental study.

Degree: 1995, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/21623

► textabstractSubglottic (endolaryngeal) injury can cause a subglottic stenosis. Chronic subglottic stenosis is defined as a partial narrowing (to complete obliteration) of the airway bounded by… (more)

Subjects/Keywords: larynx; stenosis; subglottic stenosis

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APA (6^th Edition):

Bean, J. (1995). Acquired subglottic stenosis : an experimental study. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/21623

Chicago Manual of Style (16^th Edition):

Bean, Jim. “Acquired subglottic stenosis : an experimental study.” 1995. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 07, 2021. http://hdl.handle.net/1765/21623.

MLA Handbook (7^th Edition):

Bean, Jim. “Acquired subglottic stenosis : an experimental study.” 1995. Web. 07 Mar 2021.

Vancouver:

Bean J. Acquired subglottic stenosis : an experimental study. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1995. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1765/21623.

Council of Science Editors:

Bean J. Acquired subglottic stenosis : an experimental study. [Doctoral Dissertation]. Erasmus University Medical Center; 1995. Available from: http://hdl.handle.net/1765/21623

University of Alberta

12. Roop, Sanjesh C. Surgical Recovery for Patients with Concomitant Hypertension and Lumbar Spinal Stenosis.

Degree: MS, School of Public Health, 2016, University of Alberta

URL: https://era.library.ualberta.ca/files/c5q47rn76k

► Introduction: Lumbar Spinal Stenosis (LSS) is a prevalent musculoskeletal condition affecting 8-11% of the United States general population. LSS is the most common reason requiring… (more)

▼ Introduction: Lumbar Spinal Stenosis (LSS) is a prevalent musculoskeletal condition affecting 8-11% of the United States general population. LSS is the most common reason requiring lumbar spine surgery in adults older than 65 years, with an adjusted rate of 135.5 low back surgeries per 100,000 Medicare beneficiaries. The onset of symptoms typically begins at 50 years of age and often results in localized and radiating leg pain, which limit activities such as walking. Patients with confirmed LSS may be candidates for surgery if conservative treatments have failed to manage symptoms. Patients who received surgery for LSS compared to conservative treatment experience greater improvement in pain relief, function, patient satisfaction and self-report recovery up to 4 years after treatment. The prognostic factors of poor post-operative functional outcome included: depression, cardiovascular comorbidity, disorder influencing walking ability, and scoliosis. High blood pressure (HBP) is reported in 23.2-48.3% of patients with LSS and is associated with lower health status. It is unclear whether HBP affects LSS surgical outcomes. Objective: The primary objective of this cohort study was to evaluate whether HBP was associated with poor recovery following LSS-related surgery. The secondary objectives are (1) to identify the rate of pre-surgical HBP in this community-based LSS cohort, (2) to determine whether the rate or type of post-surgical complications differ between participants with and without HBP, and (3) to describe functional recovery after surgery for LSS. Methods: Patients were identified as study candidates at the time of magnetic resonance imaging in Calgary, Alberta between April 2004 and May 2005. After implementing the study inclusion and exclusion criteria, the cohort comprised 97 participants who received spinal surgery for LSS and were followed over 2 years. Disability status was assessed pre-and post-operatively using the Oswestry Disability Index (ODI), a disease-specific questionnaire. HBP was identified by self-report, anti-hypertensive medication use, and/or diagnosis of HBP prior to surgery using Alberta Health (AH) data. Participants were interviewed before surgery and within 2 years after surgery. A multiple linear regression model was used to assess HBP as a prognostic factor for post-operative disability status. Potential confounders were included in the model to control for the effect of HBP on post-operative ODI. Results: Of the 97 participants who had back surgery, 46 were surgical participants identified by self-report alone and 25 by AH data alone, and 26 participants who were identified by both sources. The study cohort had a mean age of 71.8 (SD 12.9) years, 52% were women, and the mean number of comorbidities was 2.3 (SD 1.9). The mean ODI score was 59.0 (SD 17.0) pre-operatively and 30.1 (SD 17.7) post-operatively. Forty-nine (50.5%) participants were hypertensive. Regardless of blood pressure status, large gains in function were seen up to 2 years after surgery for LSS (effect size: 1.73;…

Subjects/Keywords: ODI; disability; lumbar; spine; hypertension; stenosis; surgery

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APA (6^th Edition):

Roop, S. C. (2016). Surgical Recovery for Patients with Concomitant Hypertension and Lumbar Spinal Stenosis. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c5q47rn76k

Chicago Manual of Style (16^th Edition):

Roop, Sanjesh C. “Surgical Recovery for Patients with Concomitant Hypertension and Lumbar Spinal Stenosis.” 2016. Masters Thesis, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/c5q47rn76k.

MLA Handbook (7^th Edition):

Roop, Sanjesh C. “Surgical Recovery for Patients with Concomitant Hypertension and Lumbar Spinal Stenosis.” 2016. Web. 07 Mar 2021.

Vancouver:

Roop SC. Surgical Recovery for Patients with Concomitant Hypertension and Lumbar Spinal Stenosis. [Internet] [Masters thesis]. University of Alberta; 2016. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/c5q47rn76k.

Council of Science Editors:

Roop SC. Surgical Recovery for Patients with Concomitant Hypertension and Lumbar Spinal Stenosis. [Masters Thesis]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/c5q47rn76k

Oregon State University

13. Smith, Courtney C. (Courtney Catherine). Treatment and Characterization of Valvular Pulmonic Stenosis and Coronary Artery Anatomy in English Bulldogs and French Bulldogs.

Degree: MS, Veterinary Science, 2016, Oregon State University

URL: http://hdl.handle.net/1957/59854

► Pulmonic stenosis (PS) is one of the most commonly encountered congenital cardiac defects in canine patients. English bulldogs have an increased risk of PS as… (more)

▼ Pulmonic stenosis (PS) is one of the most commonly encountered congenital cardiac defects in canine patients. English bulldogs have an increased risk of PS as compared to other dog breeds and have a higher reported prevalence of type II/type B/dysplastic pulmonic valve morphology. It has been shown that the dysplastic PS morphology may carry a more guarded prognosis and be less amenable to percutaneous balloon valvuloplasty (BV) procedures in canine and human patients. Due to the potentially decreased success of BV procedures in canine patients with a more dysplastic valvular phenotype, the ideal treatment for these cases may not be fully determined based on the currently published literature. There are breed predispositions observed with PS and French bulldogs may be more frequently affected with PS. Evaluation and characterization of the specific PS morphology observed in French bulldogs is lacking in veterinary medicine. Case reports have provided evidence that English bulldogs and boxer dogs have an increased risk for anomalous coronary artery anatomy that may cause or complicate PS treatment. There is a possible association with coronary artery anomalies in the French bulldog breed, although information on prevalence in this breed is lacking in the currently available veterinary literature. The primary aim of this research study was to assess the pulmonic valve morphology and prevalence of coronary artery aberrancy in English and French bulldogs with severe PS (trans- pulmonic valve pressure gradient >80mmHg based on Doppler echocardiography) using echocardiography, angiography, and computed tomography (CT) imaging modalities. A secondary study aim was to evaluate demographic data for all English and French bulldogs with PS (mild, moderate, or severe) that presented to the Oregon State University Veterinary Teaching Hospital as compared to the population of non- bulldog breeds diagnosed with PS (mild, moderate, or severe) in the same time frame. These populations were further analyzed to specifically evaluate the bulldog and non- bulldog breeds with severe PS that underwent BV procedures. Data collection and evaluation included population characteristics, electrocardiography, echocardiography, and surgical records. A third study aim was to investigate BV procedural success and survival data between bulldog and non-bulldog breeds undergoing BV for severe PS. Medical records were reviewed for French and English bulldogs presented to Oregon State University Veterinary Teaching Hospital (OSU VTH) for heart murmur evaluation or imaging prior to BV. Dogs were included if they had severe PS (pressure gradient >80 mmHg estimated via Doppler echocardiography) and confirmation of their coronary artery anatomy by either left-sided angiography or CT imaging. Echocardiographic, angiographic, and CT images were reviewed. The pulmonic annulus (PA), aortic annulus (Ao), PA:Ao and Ao:PA ratios, valvular anatomy, and coronary anatomy were assessed on each imaging modality by three observers (CS, KS, DDS) and averaged. The… Advisors/Committee Members: Scollan, Katherine F. (advisor), Cebra, Christopher K. (committee member).

Subjects/Keywords: Pulmonic stenosis; French bulldog – Cardiovascular system – Abnormalities

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APA (6^th Edition):

Smith, C. C. (. C. (2016). Treatment and Characterization of Valvular Pulmonic Stenosis and Coronary Artery Anatomy in English Bulldogs and French Bulldogs. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/59854

Chicago Manual of Style (16^th Edition):

Smith, Courtney C (Courtney Catherine). “Treatment and Characterization of Valvular Pulmonic Stenosis and Coronary Artery Anatomy in English Bulldogs and French Bulldogs.” 2016. Masters Thesis, Oregon State University. Accessed March 07, 2021. http://hdl.handle.net/1957/59854.

MLA Handbook (7^th Edition):

Smith, Courtney C (Courtney Catherine). “Treatment and Characterization of Valvular Pulmonic Stenosis and Coronary Artery Anatomy in English Bulldogs and French Bulldogs.” 2016. Web. 07 Mar 2021.

Vancouver:

Smith CC(C. Treatment and Characterization of Valvular Pulmonic Stenosis and Coronary Artery Anatomy in English Bulldogs and French Bulldogs. [Internet] [Masters thesis]. Oregon State University; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1957/59854.

Council of Science Editors:

Smith CC(C. Treatment and Characterization of Valvular Pulmonic Stenosis and Coronary Artery Anatomy in English Bulldogs and French Bulldogs. [Masters Thesis]. Oregon State University; 2016. Available from: http://hdl.handle.net/1957/59854

University of Toronto

14. Czarnecki, Andrew. Predictors of Hospital Readmission after Trans-Catheter Aortic Valve Implantation in Ontario.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/97124

►

Trans-catheter aortic valve implantation (TAVI) is the standard of care for treatment of aortic stenosis in patients deemed too high risk for surgical valve replacement.… (more)

Subjects/Keywords: aortic stenosis; hospital readmission; TAVI; 0564

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APA (6^th Edition):

Czarnecki, A. (2017). Predictors of Hospital Readmission after Trans-Catheter Aortic Valve Implantation in Ontario. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/97124

Chicago Manual of Style (16^th Edition):

Czarnecki, Andrew. “Predictors of Hospital Readmission after Trans-Catheter Aortic Valve Implantation in Ontario.” 2017. Masters Thesis, University of Toronto. Accessed March 07, 2021. http://hdl.handle.net/1807/97124.

MLA Handbook (7^th Edition):

Czarnecki, Andrew. “Predictors of Hospital Readmission after Trans-Catheter Aortic Valve Implantation in Ontario.” 2017. Web. 07 Mar 2021.

Vancouver:

Czarnecki A. Predictors of Hospital Readmission after Trans-Catheter Aortic Valve Implantation in Ontario. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1807/97124.

Council of Science Editors:

Czarnecki A. Predictors of Hospital Readmission after Trans-Catheter Aortic Valve Implantation in Ontario. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/97124

University of Houston

15. Smegner, Kelsey. Generalized CFD Study of Paravalvular Leak Associated with Transcatheter Aortic Valve Replacement.

Degree: MS, Biomedical Engineering, 2017, University of Houston

URL: http://hdl.handle.net/10657/4582

► Aortic stenosis is a growing health issue that is commonly treated by valve replacement. Transcatheter aortic valve replacement is a newer medical device being used… (more)

Subjects/Keywords: TAVR; Aortic stenosis; CFD; Fluid dynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smegner, K. (2017). Generalized CFD Study of Paravalvular Leak Associated with Transcatheter Aortic Valve Replacement. (Masters Thesis). University of Houston. Retrieved from http://hdl.handle.net/10657/4582

Chicago Manual of Style (16^th Edition):

Smegner, Kelsey. “Generalized CFD Study of Paravalvular Leak Associated with Transcatheter Aortic Valve Replacement.” 2017. Masters Thesis, University of Houston. Accessed March 07, 2021. http://hdl.handle.net/10657/4582.

MLA Handbook (7^th Edition):

Smegner, Kelsey. “Generalized CFD Study of Paravalvular Leak Associated with Transcatheter Aortic Valve Replacement.” 2017. Web. 07 Mar 2021.

Vancouver:

Smegner K. Generalized CFD Study of Paravalvular Leak Associated with Transcatheter Aortic Valve Replacement. [Internet] [Masters thesis]. University of Houston; 2017. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10657/4582.

Council of Science Editors:

Smegner K. Generalized CFD Study of Paravalvular Leak Associated with Transcatheter Aortic Valve Replacement. [Masters Thesis]. University of Houston; 2017. Available from: http://hdl.handle.net/10657/4582

University of Oxford

16. Bull, Sacha Colette. Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis.

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388

► The management of the asymptomatic patients with severe aortic stenosis (AS) is challenging; clinicians have to balance the risks of early surgery against the risk… (more)

▼ The management of the asymptomatic patients with severe aortic stenosis (AS) is challenging; clinicians have to balance the risks of early surgery against the risk that irreversible myocardial damage may occur with a conservative management strategy. It has become increasingly apparent that prognosis in asymptomatic AS depends not only on the degree of valvular stenosis, but also on the myocardial response to pressure overload and understanding the mechanisms of myocardial decompensation may help to guide management in the future. The degree of myocardial fibrosis, microvascular dysfunction, hypertrophy and left ventricular (LV) geometry may all play important roles. However, current guidelines for management of asymptomatic AS limit assessment of the myocardium to the measurement of ejection fraction with echocardiography. More advanced techniques may provide greater information that could be clinically useful. This thesis seeks to further our understanding of the mechanisms of the myocardial response to AS, using Cardiac Magnetic Resonance (CMR) in patients with moderate and severe AS. Myocardial perfusion in AS is examined in chapter 3. The results show that CMR first pass perfusion can be carried out safely and is well tolerated by AS patients. Microvascular dysfunction in these patients was associated with age, exercise time and markers of diastolic dysfunction. Myocardial strain is examined in chapter 4, utilizing a new software tool to look at strain throughout the left ventricle, and also to explore the relationship between strain and myocardial fibrosis. The results show that there are significant variations in circumferential strain measurements, depending on slice position in the LV, and also that there was no relationship found between strain and the degree of LV fibrosis. In chapter 5, the potential of CMR T1 mapping to identify fibrosis is examined using a new shortened non-contrast sequence (ShMOLLI - Shortened Modified Look-Locker Inversion) developed in our unit. CMR T1 values were validated against histological quantification of myocardial fibrosis in a large group of moderate and asymptomatic AS. A good correlation was found between ShMOLLI derived T1 values, with T1 values increasing with the severity of AS. The clinical value of measuring myocardial perfusion and LV global strain is examined in chapter 6 by linking these to prognosis. Measurement of circumferential strain could predict prognosis in asymptomatic AS, but myocardial perfusion showed poor ability to predict events. In conclusion, this thesis offers further insights into the changes that occur in the myocardium of patients with asymptomatic moderate and severe AS, using established and new CMR techniques. The clinical value of measuring these CMR parameters to aid risk stratification is shown, and the future potential for monitoring new therapies in these patients is discussed in the final chapter.

Subjects/Keywords: 616.138; Cardiovascular disease; Aortic stenosis; physiology; myocardium

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APA (6^th Edition):

Bull, S. C. (2012). Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388

Chicago Manual of Style (16^th Edition):

Bull, Sacha Colette. “Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis.” 2012. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021. http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388.

MLA Handbook (7^th Edition):

Bull, Sacha Colette. “Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis.” 2012. Web. 07 Mar 2021.

Vancouver:

Bull SC. Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis. [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2021 Mar 07]. Available from: http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388.

Council of Science Editors:

Bull SC. Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis. [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388

University of Edinburgh

17. Anand, Atul. Clinical biomarkers in older patients with aortic stenosis.

Degree: PhD, 2019, University of Edinburgh

URL: http://hdl.handle.net/1842/35901

► The incidence of degenerative aortic stenosis is increasing with an ageing population. Valve replacement is the only proven treatment, but this carries significant procedural risk… (more)

▼ The incidence of degenerative aortic stenosis is increasing with an ageing population. Valve replacement is the only proven treatment, but this carries significant procedural risk in older people. Current guidelines advocate intervention in symptomatic severe aortic stenosis, but non-cardiac symptoms and comorbidity may obscure this assessment. Clinical biomarkers offer the potential for objective patient assessment. My aim was to firstly assess the validity and reproducibility of novel blood biomarkers of disease progression in aortic stenosis. Secondly, in older patients considered for valve replacement, my aim was to compare measures of frailty with conventional surgical risk assessment. In 265 patients with asymptomatic aortic stenosis and 46 healthy controls, I assessed serum concentrations of the sarcomeric protein cardiac myosin binding protein C (cMyC) and objective markers of disease progression and mortality. cMyC concentrations were independently associated with imaging evidence of left ventricular mass, fibrosis volume and extracellular volume. These relationships were not observed in healthy controls. cMyC concentrations were also associated with all-cause mortality over 11 years of follow-up. This suggests a role for cMyC as a novel objective biomarker of aortic stenosis disease severity. Other blood biomarkers including cardiac troponin, brain-type natriuretic peptide (BNP) and galectin-3 have been suggested as disease biomarkers in aortic stenosis. However, performance and precision of these assays has not been described in older patients. In a study of analytical and biological variability, I undertook repeated hourly and weekly blood sampling for cardiac troponin, BNP and galectin-3 in 14 subjects with severe asymptomatic aortic stenosis. These biomarkers demonstrated low indices of individuality, implying that interpretation requires serial testing for change rather than isolated elevated blood concentrations. The reference change values for weekly fresh sampling were 42% for cardiac troponin, 55% for BNP and 14% for galectin. These values for cardiac troponin and BNP were lower than equivalent studies in healthy controls and in stable heart failure. To assess the role of frailty in the assessment of patients for aortic valve replacement, I first performed a systematic review and meta-analysis of studies including frailty assessment before Transcatheter Aortic Valve Implantation (TAVI). This procedure is reserved for patients considered at prohibitive risk of complication from conventional open-heart surgery. Ten cohort studies with 4,592 TAVI patients were included. Frailty was associated with increased risk of early and late mortality, and use of an objective frailty tool rather than subjective assessment identified those at highest risk; these patients experienced greater than double the mortality risk of non-frail individuals. In 185 patients with severe aortic stenosis, I prospectively assessed frailty using four tools: the Fried phenotype, Edmonton Frail Scale, Short Physical Performance…

Subjects/Keywords: ageing; aortic stenosis; frailty; risk prediction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Anand, A. (2019). Clinical biomarkers in older patients with aortic stenosis. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/35901

Chicago Manual of Style (16^th Edition):

Anand, Atul. “Clinical biomarkers in older patients with aortic stenosis.” 2019. Doctoral Dissertation, University of Edinburgh. Accessed March 07, 2021. http://hdl.handle.net/1842/35901.

MLA Handbook (7^th Edition):

Anand, Atul. “Clinical biomarkers in older patients with aortic stenosis.” 2019. Web. 07 Mar 2021.

Vancouver:

Anand A. Clinical biomarkers in older patients with aortic stenosis. [Internet] [Doctoral dissertation]. University of Edinburgh; 2019. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1842/35901.

Council of Science Editors:

Anand A. Clinical biomarkers in older patients with aortic stenosis. [Doctoral Dissertation]. University of Edinburgh; 2019. Available from: http://hdl.handle.net/1842/35901

18. 심, 주현. Analysis of ultrasonic parameters of pylorus in idiopathic hypertrophic pyloric stenosis patients: a retrospective study.

Degree: 2020, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/19278 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000029846

►

PURPOSE: Pyloric muscle thickness (PMT) equal to or greater than 4mm and canal length equal to or greater than 16mm are widely accepted for diagnosis… (more)

▼

PURPOSE: Pyloric muscle thickness (PMT) equal to or greater than 4mm and canal length equal to or greater than 16mm are widely accepted for diagnosis of idiopathic hypertrophic pyloric stenosis (IHPS). However, up to 25% of IHPS patients show discordant ultrasonic parameters compared to current diagnostic criteria. We analyzed the ultrasonic parameters of pylorus of IHPS patients to discover their correlation to patient characteristics and aimed to find a new diagnostic value. METHOD: Medical records of 131 IHPS patients who received pyloromyotomy from 1994 to 2016 were reviewed. All patients presented with characteristic clinical symptoms. The patients were divided into two groups according to their eligibility for current criteria as Discordance group (n=32) and Concordance group (n=99). Baseline characteristics were reviewed and ultrasonic parameters were measured, and then the volume of the pylorus was estimated by calculation using the parameters. RESULTS: The proportion of neonates were higher in Discordance group (43.8% vs.13.1%, p<0.001). Mean postconceptional age of Concordance group was 19.4 days older than that of Discordance group at the time of US examination (p<0.001). Average weight of Concordance group was 4.29 0.74kg while that of Discordance group were 3.76 0.91kg. Also, the median chronological age at the time of US was 28.0 [21, 35] days in Discordance group and 44.0 [29.5, 54.5] days in Concordance group (p<0.001). In Discordance group, proportion of PMT over PD was 31.87 3.24%, while it was 35.06 3.61 % in Concordance group. Postconceptional age and being neonate were remained as significant variables after multivariate linear regression (R2=0.390). CONCLUSION: Pyloric volume of IHPS patients were strongly related to their postconceptional age, and it suggested that the diagnostic criteria may differ according to the patient’s size and time of diagnosis. Future diagnostic criteria for IHPS should reflect the dynamic nature of the patients.

서론: 영아기의 비후성 유문 협착증(IHPS)은 비교적 흔한 복부수술의 원인 질환으로 특징적인 구토 증상과 혈중 전해질 이상 소견으로 임상적 진단이 쉽게 내려진다. 확진은 복부초음파를 통한 유문근 두께 및 길이 측정으로 가능하다. 진단 기준은 문헌마다 차이는 있으나 두께는 3mm이상, 유문관의 길이는 15mm 이상으로 널리 이용되고 있다. 저자들은 IHPS로 진단되어 수술을 시행한 환아에서 후향적으로 초음파 소견을 분석하여 공용되고 있는 초음파 소견의 진단 기준과 차이가 있는지 비교하여 보고자 하였다. 또한 유문근의 직경, 두께 및 길이의 측정값이 환아의 특정인자들과 비례적인 상관관계가 있는지 확인하고자 하였다. 방법: 본원에서 1994년부터 2016년까지 IHPS 로 진단되어 수술을 시행받은 131명의 환아를 대상으로 후향적으로 분석하였다. 모두 특징적인 임상 증상으로 복부 초음파를 시행하였고 개복을 통한 유문근절개술시 모두 유문근 비후가 확인되었다. 분석을 위해 수술 전 초음파 소견상 보이는 유문근의 두께, 직경, 유문관 길이를 다시 정밀하게 계측하였다. 근육 두께는 유문부 단면에서 장막층, 점막하층, 유문관의 점막층을 제외한 근육 부분을, 직경은 유문부의 중심 부분 중 최대 길이를 측정하였다. 유문관 길이 역시 재측정하였다. 유문근의 두꺼워진 정도를 비교하기 위해 유문근 용적을 계산하였고 환아의 각 항목과 유문근 용적의 관계는 이변량 상관계수 및 편상관관계 분석을 이용하여 확인하였다. 결과: 환아들은 한국에서 통용되는 유문근 비후 진단기준 (유문근 두께 4mm 이상, 유문관 길이 16mm 이상)에 부합하는 군과 적합한 군으로 나누어 비교하였다. 신생아 비율은 부합군에서 더 높았다 (43.8% vs.13.1%, p<0.001). 평균 교정연령은 적합군이 부합군보다 19.4일 많았고 초음파 검사시 평균 몸무게 또한 4.29 0.74kg로 3.76 0.91kg인 부합군보다 높게 측정되었다. 또한 검사 당시 출생 후 일수는 부합군에서 중위수가 28일, 적합군에서 44일로 적합군이 더 많았다. 부합군에서 유문 직경 대비 유문근 두께의 비율은 31.87 3.24%이며 적합군에서는 35.06…

Advisors/Committee Members: 대학원 의학과, 201224106, 심, 주현.

Subjects/Keywords: Hypertrophic pyloric stenosis; Ultrasonography; Pylorus; Neonate

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APA (6^th Edition):

심, �. (2020). Analysis of ultrasonic parameters of pylorus in idiopathic hypertrophic pyloric stenosis patients: a retrospective study. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/19278 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000029846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

심, 주현. “Analysis of ultrasonic parameters of pylorus in idiopathic hypertrophic pyloric stenosis patients: a retrospective study.” 2020. Thesis, Ajou University. Accessed March 07, 2021. http://repository.ajou.ac.kr/handle/201003/19278 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000029846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

심, 주현. “Analysis of ultrasonic parameters of pylorus in idiopathic hypertrophic pyloric stenosis patients: a retrospective study.” 2020. Web. 07 Mar 2021.

Vancouver:

심 �. Analysis of ultrasonic parameters of pylorus in idiopathic hypertrophic pyloric stenosis patients: a retrospective study. [Internet] [Thesis]. Ajou University; 2020. [cited 2021 Mar 07]. Available from: http://repository.ajou.ac.kr/handle/201003/19278 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000029846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

심 �. Analysis of ultrasonic parameters of pylorus in idiopathic hypertrophic pyloric stenosis patients: a retrospective study. [Thesis]. Ajou University; 2020. Available from: http://repository.ajou.ac.kr/handle/201003/19278 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000029846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Kozuma, Ken. The bright and the dark sides of brachytherapy: mechanisms of stenosis reduction and findings of intracoronary β-radiation therapy revealed by IVUS-3D and QCA.

Degree: Department of Cardiology, 2001, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/23521

► Sincethe first percutaneous coronary intervention, 24 years ago, the field of interventional cardiology has continued to grow rapidly. Although PTCA has demonstrated superiority to medical… (more)

Subjects/Keywords: Brachytherapy; cardiology; stenosis

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APA (6^th Edition):

Kozuma, K. (2001). The bright and the dark sides of brachytherapy: mechanisms of stenosis reduction and findings of intracoronary β-radiation therapy revealed by IVUS-3D and QCA. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/23521

Chicago Manual of Style (16^th Edition):

Kozuma, Ken. “The bright and the dark sides of brachytherapy: mechanisms of stenosis reduction and findings of intracoronary β-radiation therapy revealed by IVUS-3D and QCA.” 2001. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 07, 2021. http://hdl.handle.net/1765/23521.

MLA Handbook (7^th Edition):

Kozuma, Ken. “The bright and the dark sides of brachytherapy: mechanisms of stenosis reduction and findings of intracoronary β-radiation therapy revealed by IVUS-3D and QCA.” 2001. Web. 07 Mar 2021.

Vancouver:

Kozuma K. The bright and the dark sides of brachytherapy: mechanisms of stenosis reduction and findings of intracoronary β-radiation therapy revealed by IVUS-3D and QCA. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2001. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1765/23521.

Council of Science Editors:

Kozuma K. The bright and the dark sides of brachytherapy: mechanisms of stenosis reduction and findings of intracoronary β-radiation therapy revealed by IVUS-3D and QCA. [Doctoral Dissertation]. Erasmus University Medical Center; 2001. Available from: http://hdl.handle.net/1765/23521

University of Toronto

20. Rumman, Rawan K. Middle Aortic Syndrome and Renal Artery Stenosis: Disease Beyond the Arch.

Degree: PhD, 2016, University of Toronto

URL: http://hdl.handle.net/1807/76806

► Background Middle aortic syndrome (MAS) is a rare childhood disease, often associated with renal artery stenosis (RAS). The etiology is unknown in most cases, but… (more)

Subjects/Keywords: Abdominal aorta; Aortic stenosis; Middle aortic syndrome; Renal artery stenosis; Renovascular hypertension; Vascular imaging; 0564

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APA (6^th Edition):

Rumman, R. K. (2016). Middle Aortic Syndrome and Renal Artery Stenosis: Disease Beyond the Arch. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/76806

Chicago Manual of Style (16^th Edition):

Rumman, Rawan K. “Middle Aortic Syndrome and Renal Artery Stenosis: Disease Beyond the Arch.” 2016. Doctoral Dissertation, University of Toronto. Accessed March 07, 2021. http://hdl.handle.net/1807/76806.

MLA Handbook (7^th Edition):

Rumman, Rawan K. “Middle Aortic Syndrome and Renal Artery Stenosis: Disease Beyond the Arch.” 2016. Web. 07 Mar 2021.

Vancouver:

Rumman RK. Middle Aortic Syndrome and Renal Artery Stenosis: Disease Beyond the Arch. [Internet] [Doctoral dissertation]. University of Toronto; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1807/76806.

Council of Science Editors:

Rumman RK. Middle Aortic Syndrome and Renal Artery Stenosis: Disease Beyond the Arch. [Doctoral Dissertation]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/76806

University of Alberta

21. Hay, Wayne Bruce. Effect of downstream resistance on the pressure drop across minor stenoses.

Degree: MS, Department of Physiology, 1976, University of Alberta

URL: https://era.library.ualberta.ca/files/c247dv560

Subjects/Keywords: Aortic valve – Stenosis.; Blood pressure.; Arteries – Stenosis.; Blood flow.

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APA (6^th Edition):

Hay, W. B. (1976). Effect of downstream resistance on the pressure drop across minor stenoses. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c247dv560

Chicago Manual of Style (16^th Edition):

Hay, Wayne Bruce. “Effect of downstream resistance on the pressure drop across minor stenoses.” 1976. Masters Thesis, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/c247dv560.

MLA Handbook (7^th Edition):

Hay, Wayne Bruce. “Effect of downstream resistance on the pressure drop across minor stenoses.” 1976. Web. 07 Mar 2021.

Vancouver:

Hay WB. Effect of downstream resistance on the pressure drop across minor stenoses. [Internet] [Masters thesis]. University of Alberta; 1976. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/c247dv560.

Council of Science Editors:

Hay WB. Effect of downstream resistance on the pressure drop across minor stenoses. [Masters Thesis]. University of Alberta; 1976. Available from: https://era.library.ualberta.ca/files/c247dv560

Freie Universität Berlin

22. Risteska, Katerina. The topical application of Mitomycin C in the treatment of scar formation and stenosis in hollow organs of the neck and head and ear.

Degree: 2012, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9712

► Mitomycin C has been known since 1958 as an antitumoral antibiotic, a derivative of Streptomyces caespitosus. From 1963 it has been successfully used topical in… (more)

▼ Mitomycin C has been known since 1958 as an antitumoral antibiotic, a derivative of Streptomyces caespitosus. From 1963 it has been successfully used topical in the field of ophthalmology in the suppression of post- operative scar formation. For this aim it is also used topical in the treatment of stenosis in hollow organs since 1998. The retrospective analysis examined the adjuvant efficiency of MMC as well as potential side effects and correct diagnosis during 10 years. Methods: The analysis includes 40 patients, mean age of 54 years, with stenosis in the larynx, trachea, pharynx, esophagus, choanen and external ear channel. A retrospective analysis on the basis of clinical disease courses and findings covering an examination period of 10 years. MMC has been used always with 1 mg/ml for 2 minutes sometimes repeated. Results: After combined application of topical MMC and laser- surgical/ open-surgical intervention a sustained improvement in the stenosis level was achieved. Pre-operative 65,3% of the patients with stenosis of the larynx and trachea showed an high stenosis level. Post-operative 72% showed an mild or non stenosis. The forced inspiratory volume in 1 second increased significantly from pre-operative 0,96 l to post-operative 2,20 l and 93,7 % of the patients stated an clinical improvement of their symptoms. Discussion: The results of this 10-year-analysis of adjuvant MMC without any side effects in the treatment of stenosis in hollow organs point to the efficiency in an combined treatment. Prior the correct diagnosis and surgical treatment is necessary. The clinical findings confirmed an enhancement in the containment of complex cases. Advisors/Committee Members: [email protected] (contact), w (gender), Prof. Dr. med. G. Schönfelder (inspector), Prof. Dr. Dr.-Ing. J. Lademann (inspector), Prof. Dr. med. J.-W. Oestmann (inspector), Priv.-Doz. Dr. med. B. Sedlmaier (firstReferee), Prof. Dr. med. T. Nawka (furtherReferee), Priv.-Doz. Dr. med. P. Schneider (furtherReferee).

Subjects/Keywords: Mitomycin C; topical application; scar formation; tracheal stenosis; laryngeal stenosis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Risteska, K. (2012). The topical application of Mitomycin C in the treatment of scar formation and stenosis in hollow organs of the neck and head and ear. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Risteska, Katerina. “The topical application of Mitomycin C in the treatment of scar formation and stenosis in hollow organs of the neck and head and ear.” 2012. Thesis, Freie Universität Berlin. Accessed March 07, 2021. http://dx.doi.org/10.17169/refubium-9712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Risteska, Katerina. “The topical application of Mitomycin C in the treatment of scar formation and stenosis in hollow organs of the neck and head and ear.” 2012. Web. 07 Mar 2021.

Vancouver:

Risteska K. The topical application of Mitomycin C in the treatment of scar formation and stenosis in hollow organs of the neck and head and ear. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2021 Mar 07]. Available from: http://dx.doi.org/10.17169/refubium-9712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Risteska K. The topical application of Mitomycin C in the treatment of scar formation and stenosis in hollow organs of the neck and head and ear. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-9712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

23. Paul, Anup K. Assessment of the Severity of Aortic Stenosis using Aortic Valve Coefficient.

Degree: PhD, Engineering and Applied Science: Mechanical Engineering, 2016, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470672658

► Introduction. Accurate assessment of the severity of stenosis is critical in patients with aortic stenosis (AS). The ambiguities and imprecisions of the current diagnostic parameters… (more)

▼ Introduction. Accurate assessment of the severity of stenosis is critical in patients with aortic stenosis (AS). The ambiguities and imprecisions of the current diagnostic parameters can result in sub-optimal clinical decisions. In this research, we investigated the feasibility of using the functional diagnostic parameter AVC (Aortic Valve coefficient: ratio of the total transvalvular pressure drop to the proximal dynamic pressure) in the non-invasive assessment of AS and also for improving the concordance between non-invasive and invasive assessment of AS severity. Methods. AVC was calculated using Doppler (non-invasive) and cardiac catheterization (invasive) measured parameters obtained from retrospective chart reviews. Linear regression analysis was performed to assess any significant correlations between AVC and the measured parameters and also between the Doppler and catheterization derived parameters. To accurately evaluate the hemodynamics for diseased aortic valves using patient-specific computational formulations it is necessary to determine the pre-stressed condition of the in-vivo geometry. The previously developed optimization based inverse algorithm was improved to evaluate the pre-stress due to the change in arterial property of the tapered femoral artery. The compliance of the artery for a range of systemic pressures was also computed. Subsequently, a hybrid inverse algorithm was developed to determine the load-free and pre-stressed condition of patient-specific arterial geometries obtained from clinical MRI. The algorithm included the in-vivo axial stretch, lumen pressure and the patient-specific tissue properties determined from clinical data. <I>Results. A statistically significant and strong combined linear correlation (r = 0.93, p < 0.001) of AVC with the transvalvular pressure drop and the left ventricular outflow tract velocity was observed. The mean values of AVC were shown to better delineate moderate and severe stenosis (54% difference). An improved significant correlation was observed between Doppler and catheter derived AVC (r = 0.92, p < 0.05) when compared to the correlation between Doppler and catheter measurements of mean pressure drop (r = 0.72, p 0.05) and aortic valve area (r = 0.64, p < 0.05). The results obtained from the optimization based inverse algorithm showed that the change in arterial wall property caused significant variation in the dimensions of the load-free artery and insignificant variation in the dimensions and the circumferential stress of the pre-stressed artery. Further, the computed compliance of the artery was significantly influenced by the change in the average arterial pressure. The results obtained from the hybrid inverse algorithm showed that the radial shrinkage and thickening of the load-free patient-specific arterial wall was non-uniform. The load-free inner and outer diameters of the patient-specific artery were 33-38% and 22-25% smaller, respectively, than the corresponding in-vivo</I> diameters. The variation of the pre-stressed diameters from… Advisors/Committee Members: Banerjee, Rupak (Committee Chair).

Subjects/Keywords: Biomedical Research; Aortic stenosis; aortic valve disease; inverse algorthm; pre-stressing; Doppler assessment of aortic stenosis; finite element modeling

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APA (6^th Edition):

Paul, A. K. (2016). Assessment of the Severity of Aortic Stenosis using Aortic Valve Coefficient. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470672658

Chicago Manual of Style (16^th Edition):

Paul, Anup K. “Assessment of the Severity of Aortic Stenosis using Aortic Valve Coefficient.” 2016. Doctoral Dissertation, University of Cincinnati. Accessed March 07, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470672658.

MLA Handbook (7^th Edition):

Paul, Anup K. “Assessment of the Severity of Aortic Stenosis using Aortic Valve Coefficient.” 2016. Web. 07 Mar 2021.

Vancouver:

Paul AK. Assessment of the Severity of Aortic Stenosis using Aortic Valve Coefficient. [Internet] [Doctoral dissertation]. University of Cincinnati; 2016. [cited 2021 Mar 07]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470672658.

Council of Science Editors:

Paul AK. Assessment of the Severity of Aortic Stenosis using Aortic Valve Coefficient. [Doctoral Dissertation]. University of Cincinnati; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470672658

University of Auckland

24. O'Brien, Kieran Robert. Understanding and measuring flow in aortic stenosis with MRI.

Degree: 2009, University of Auckland

URL: http://hdl.handle.net/2292/4488

► In patients with aortic stenosis, accurate assessment of severity with echocardiography is central to surgical decision making. But, when image quality is poor or equivocal… (more)

▼ In patients with aortic stenosis, accurate assessment of severity with echocardiography is central to surgical decision making. But, when image quality is poor or equivocal results obtained, another robust non-invasive technique would be invaluable. Cardiac magnetic resonance (CMR) may be a useful alternative. Phase contrast CMR can measure ow and velocity, therefore it is theoretically possible to estimate the main determinant of severity aortic valve area, using the continuity approach. However, it was found that the phase contrast estimate of stroke volume, sampled in the stenotic jet, systematically underestimated left ventricular stroke volume. This underestimation was greater with increasing aortic stenosis severity. Critical clinical treatment decisions depend on the ability to reliably differentiate between patients with moderate and severe aortic stenosis. To achieve accurate estimation of aortic valve areas the velocity and ow data obtained in these turbulent, high velocity jets must be accurate. In this thesis, non-stenotic and stenotic phantoms were designed and constructed to experimentally interrogate the error. It was determined that signal loss, due to intravoxel dephasing, decreased the reliability of the measured forward ow jet velocities. Extreme signal loss in the jet eventuated in salt and pepper noise, which, with a mean velocity of zero, resulted in the underestimation. Intravoxel dephasing signal loss due to higher order motions, turbulence and spin mixing could all be mitigated by reducing the duration of the velocity sensitivity gradients and shortening the overall echo time (TE). However, improvements in an optimised PC sequence (TE 1:5ms) were not satisfactory. Flow estimates remained variable and were underestimated beyond the aortic valve. To reduce the TE further, a new phase contrast pulse sequence based on an ultrashort TE readout trajectory and velocity dependent slice excitation with gradient inversion was designed and implemented. The new sequence's TE is approximately 25% (0:65ms) of what is currently clinically available (TE 2:8ms). Good agreement in the phantom was maintained up to very high ow rates with improved signal characteristics shown in-vivo. This new phase contrast pulse sequence is worthy of further investigation as an accurate evaluation of patients with aortic stenosis. Advisors/Committee Members: Associate Professor Alistair Young.

Subjects/Keywords: Magnetic Resonace Imaging; Aortic stenosis; Phase contrast; turbulent jets; velocity; flow

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APA (6^th Edition):

O'Brien, K. R. (2009). Understanding and measuring flow in aortic stenosis with MRI. (Doctoral Dissertation). University of Auckland. Retrieved from http://hdl.handle.net/2292/4488

Chicago Manual of Style (16^th Edition):

O'Brien, Kieran Robert. “Understanding and measuring flow in aortic stenosis with MRI.” 2009. Doctoral Dissertation, University of Auckland. Accessed March 07, 2021. http://hdl.handle.net/2292/4488.

MLA Handbook (7^th Edition):

O'Brien, Kieran Robert. “Understanding and measuring flow in aortic stenosis with MRI.” 2009. Web. 07 Mar 2021.

Vancouver:

O'Brien KR. Understanding and measuring flow in aortic stenosis with MRI. [Internet] [Doctoral dissertation]. University of Auckland; 2009. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2292/4488.

Council of Science Editors:

O'Brien KR. Understanding and measuring flow in aortic stenosis with MRI. [Doctoral Dissertation]. University of Auckland; 2009. Available from: http://hdl.handle.net/2292/4488

Universidade do Rio Grande do Sul

25. Enéas, Larissa Valency. Acurácia do estridor para o diagnóstico de estenose subglótica por intubação em pacientes pediátricos.

Degree: 2013, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/78527

►

Objetivos: Determinar a acurácia do estridor em predizer a ocorrência de estenose subglótica (ESG) por intubação em pacientes pediátricos quando comparado ao seu diagnóstico por… (more)

▼

Objetivos: Determinar a acurácia do estridor em predizer a ocorrência de estenose subglótica (ESG) por intubação em pacientes pediátricos quando comparado ao seu diagnóstico por endoscopia de via aérea. Delineamento: Coorte Prospectiva. Métodos: Foram elegíveis todas as crianças de 28 dias a quatro anos de idade internadas na Unidade de Terapia Intensiva Pediátrica do Hospital de Clínicas de Porto Alegre que necessitaram de intubação endotraqueal por mais de 24 horas. Foram excluídas as com história de intubação, doença laríngea prévia, presença de traqueostomia atual ou no passado, presença de malformações craniofaciais e aquelas consideradas portadoras de doença terminal. Foram acompanhadas diariamente e, após a extubação, submetidas à fibronasolaringoscopia (FNL). Novo exame era realizado em sete a dez dias naquelas com alterações moderadas a graves no primeiro. Se essas persistissem ou surgissem sintomas, independentemente da FNL inicial, realizava-se laringoscopia sob anestesia geral. Após a extubação, verificou-se diariamente a ocorrência de estridor, classificado como presente ou ausente. Resultados: Foram acompanhados, de novembro de 2005 a agosto de 2012, 194 pacientes. A incidência de estridor pós-extubação foi de 43,81%. O estridor apresentou uma sensibilidade de 77,78% (IC 95%: 51,9 – 92,6) e especificidade de 59,66% (IC 95%: 52,0 – 66,9) em detectar ESG nessa amostra, o valor preditivo positivo (VPP) foi de 16,47% (IC 95%: 9,6 – 26,4) e o valor preditivo negativo (VPN) foi de 96,33% (IC 95%: 90,3 – 98,8). O estridor quando presente por mais de 72 horas ou quando esse surgiu após as primeiras 72 horas da extubação apresentou uma sensibilidade de 66,67% (IC 95%: 41,2 – 85,6) e especificidade de 88,5% (IC 95%: 83,1 – 93,1). O VPP foi de 38,8% (IC 95%: 22,4 – 57,7) e o VPN foi de 96,23 (IC 95%: 91,6 – 98,5). A área da curva ROC foi 0,78 (IC 95%: 0,65 – 0,91). Conclusões: A ausência de estridor mostrou-se adequada para afastar o diagnóstico de ESG por intubação em pacientes pediátricos após o período neonatal. Melhor especificidade foi encontrada quando o estridor ocorreu por mais de 72 horas após a extubação ou quando teve o início depois desse período. A partir desse estudo, parece adequado indicar endoscopia de via aérea, para a confirmação de ESG, apenas naqueles pacientes que apresentarem estridor após 72 horas da extubação.

Objective: To determine the accuracy of stridor in predicting the occurrence of postintubation subglottic stenosis (SGS) in pediatric patients when compared with endoscopy airway diagnosis. Design: Prospective cohort. Methods: Children aged 28 days to four years admitted to the Pediatric Intensive Care Unit of Hospital de Clinicas de Porto Alegre who required endotracheal intubation for more than 24 hours were eligible for study. Patients with previous intubation, history of laryngeal disease, current or past tracheostomy, presence of craniofacial malformations and those considered terminal by the staff were excluded from the study. Children were monitored daily and underwent…

Advisors/Committee Members: Marostica, Paulo José Cauduro.

Subjects/Keywords: Subglottic stenosis; Constrição patológica; Stridor; Sons respiratórios; Accuracy; Laringoscopia; Laryngoscopy

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APA (6^th Edition):

Enéas, L. V. (2013). Acurácia do estridor para o diagnóstico de estenose subglótica por intubação em pacientes pediátricos. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/78527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Enéas, Larissa Valency. “Acurácia do estridor para o diagnóstico de estenose subglótica por intubação em pacientes pediátricos.” 2013. Thesis, Universidade do Rio Grande do Sul. Accessed March 07, 2021. http://hdl.handle.net/10183/78527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Enéas, Larissa Valency. “Acurácia do estridor para o diagnóstico de estenose subglótica por intubação em pacientes pediátricos.” 2013. Web. 07 Mar 2021.

Vancouver:

Enéas LV. Acurácia do estridor para o diagnóstico de estenose subglótica por intubação em pacientes pediátricos. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2013. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10183/78527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Enéas LV. Acurácia do estridor para o diagnóstico de estenose subglótica por intubação em pacientes pediátricos. [Thesis]. Universidade do Rio Grande do Sul; 2013. Available from: http://hdl.handle.net/10183/78527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

26. Suwankong, N. Degenerative lumbosacral stenosis in dogs.

Degree: 2007, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/21307

► Degenerative lumbosacral stenosis (DLS) is now recognized as a significant cause of caudal lumbar pain and pelvic limb lameness in dogs. The condition includes lumbosacral… (more)

▼ Degenerative lumbosacral stenosis (DLS) is now recognized as a significant cause of caudal lumbar pain and pelvic limb lameness in dogs. The condition includes lumbosacral intervertebral disc degeneration and protrusion, spondylosis deformans, sclerosis of the vertebral end plates, osteoarthrosis of articular facets, ventral sacral subluxation, and hypertrophy of the ligamentum flavum and joint capsules. The clinical signs are caudal lumbar pain, pelvic limb lameness, reluctance to jump, rise and climb stairs, and neurological signs. Diagnosis of DLS is based on the history, clinical signs, clinical examination, and imaging findings. The surgical treatment of dogs with DLS aims to relieve the compression on the cauda equina nerve roots. The first aim of this thesis was to determine the diagnostic value of advanced imaging techniques. The findings between computed tomography (CT), magnetic resonance imaging (MRI), and surgery were compared There was substantial to almost perfect agreement between the findings on CT and MRI for the degree and location of disc protrusion, the position of the dural sac, the presence of epidural fat, and swelling of nerve roots. There was slight to fair agreement between imaging and surgical findings for the degree and location of disc protrusion, and swelling of nerve roots. CT and MRI provided excellent discrimination of compressive tissues in the spinal canal. The second aim was to investigate the somatosensory function in dogs affected by DLS. Compressive lesions on the cauda equina at L7-S1 in dogs with DLS prolonged the mean latency of tibial nerve somatosensory evoked potentials in dogs with DLS compared with those in clinically normal dogs. The third aim was to objectively evaluate, using force plate analysis (FPA), the result of decompressive surgery in dogs with DLS. In 12 dogs, surgical treatment restored the propulsive forces of the pelvic limbs in a 6-month period after surgery. The long-term outcome of decompressive surgery in 35 dogs with DLS was assessed by FPA and questionnaires to owners. The propulsive forces of the pelvic limbs, and the ratio between the propulsive forces of the pelvic limbs and the thoracic limbs decreased significantly at 3 days after surgery, and increased during 6 months follow-up, but remained smaller than control values with long-term (? 1.5 years) follow up. In contrast, the results from the questionnaires showed significant improvement 6 months to 1.5 years after surgery compared to findings before surgery, and the majority of owners were satisfied. Biomechanical flexion-extension load forces were assessed in cadaveric lumbosacral specimens of healthy middle-sized dogs, before and after dorsal laminectomy with partial discectomy, and after pedicle screw-rod fixation. The flexion and extension load forces after dorsal laminectomy with partial discectomy, were not significantly different from those in the native lumbosacral spine specimen. After pedicle screw-rod fixation, the motions in the instrumented spine segment decreased significantly.…

Subjects/Keywords: Diergeneeskunde; lumbosacral stenosis; decompressive surgery; force plate; evoked potentials; biomechanics; dog

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Suwankong, N. (2007). Degenerative lumbosacral stenosis in dogs. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/21307

Chicago Manual of Style (16^th Edition):

Suwankong, N. “Degenerative lumbosacral stenosis in dogs.” 2007. Doctoral Dissertation, Universiteit Utrecht. Accessed March 07, 2021. http://dspace.library.uu.nl:8080/handle/1874/21307.

MLA Handbook (7^th Edition):

Suwankong, N. “Degenerative lumbosacral stenosis in dogs.” 2007. Web. 07 Mar 2021.

Vancouver:

Suwankong N. Degenerative lumbosacral stenosis in dogs. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2007. [cited 2021 Mar 07]. Available from: http://dspace.library.uu.nl:8080/handle/1874/21307.

Council of Science Editors:

Suwankong N. Degenerative lumbosacral stenosis in dogs. [Doctoral Dissertation]. Universiteit Utrecht; 2007. Available from: http://dspace.library.uu.nl:8080/handle/1874/21307

27. Fairbanks, Allison Marie. Annual coronary artery calcium progression and lifestyle modification.

Degree: M.P.H., 2009, Oregon Health Sciences University

URL: doi:10.6083/M4416V1G ; http://digitalcommons.ohsu.edu/etd/355

Subjects/Keywords: Coronary Artery Disease; Carotid Stenosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fairbanks, A. M. (2009). Annual coronary artery calcium progression and lifestyle modification. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4416V1G ; http://digitalcommons.ohsu.edu/etd/355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fairbanks, Allison Marie. “Annual coronary artery calcium progression and lifestyle modification.” 2009. Thesis, Oregon Health Sciences University. Accessed March 07, 2021. doi:10.6083/M4416V1G ; http://digitalcommons.ohsu.edu/etd/355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fairbanks, Allison Marie. “Annual coronary artery calcium progression and lifestyle modification.” 2009. Web. 07 Mar 2021.

Vancouver:

Fairbanks AM. Annual coronary artery calcium progression and lifestyle modification. [Internet] [Thesis]. Oregon Health Sciences University; 2009. [cited 2021 Mar 07]. Available from: doi:10.6083/M4416V1G ; http://digitalcommons.ohsu.edu/etd/355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fairbanks AM. Annual coronary artery calcium progression and lifestyle modification. [Thesis]. Oregon Health Sciences University; 2009. Available from: doi:10.6083/M4416V1G ; http://digitalcommons.ohsu.edu/etd/355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oulu

28. Eriksen, H. (Heidi). Carboxyterminal telopeptide structures of type I collagen in various human tissues.

Degree: 2010, University of Oulu

URL: http://urn.fi/urn:isbn:9789514262449

► Abstract Type I collagen is the main connective tissue protein in vertebrates. The cross-linking and correct organisation of the molecules is crucial for the proper… (more)

▼ Abstract Type I collagen is the main connective tissue protein in vertebrates. The cross-linking and correct organisation of the molecules is crucial for the proper function of the tissue. Traditionally collagen cross-linking has been studied using chemical cross-link analyses. However, this does not distinguish between the collagen types or the location of the cross-link within the molecule. The focus in this work was to study the carboxyterminal telopeptide domain of type I collagen for the differently cross-linked forms. An immunochemical approach was used and a new immunoassay, SP4, was developed for the detection of immaturely cross-linked peptide forms. The differently cross-linked structures were purified and characterised from human bone by using SP4 together with the earlier developed ICTP assay for trivalently cross-linked C-terminal telopeptide form. It was found that the majority of the trivalent cross-links in the C-terminal telopeptide were presently unknown structures, other than pyridinoline. A non-cross-linked form of C-terminal telopeptide of α1-chain of type I collagen was also discovered in bone. The epitope of the ICTP assay was characterised and found to reside in the phenylalanine rich region of the ICTP peptide. MMP-9, but not cathepsin K, mediated breakdown of the collagenous matrix was found to produce a peptide detectable by the ICTP assay. Healthy human Achilles tendon comprises mainly of type I collagen. In ruptured Achilles tendons, an increased type III collagen content was found. Since the synthesis of type III collagen was not increased, it is postulated that the type III collagen must have accumulated over a long period of time indicative of a long-lasting microtraumatic process in the tendon before the total rupture occurred. The ICTP content was increased and the ratio of SP4 to ICTP decreased in calcified stenotic aortic valves suggesting a change in the molecular organisation and cross-linking towards the type found in human bone. The total collagen content was dramatically decreased in the calcified valves. Both in the Achilles tendons and in the aortic valves, the ICTP content was found to decrease with age with a concomitant increase in the variants of the C-terminal telopeptide structures detectable with the SP4 assay, pointing to a change in the molecular organisation of the collagenous matrix in these tissues.

Subjects/Keywords: Achilles tendon rupture; aortic valve stenosis; bone; calcification; collagen; cross-linking

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Eriksen, H. (. (2010). Carboxyterminal telopeptide structures of type I collagen in various human tissues. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514262449

Chicago Manual of Style (16^th Edition):

Eriksen, H (Heidi). “Carboxyterminal telopeptide structures of type I collagen in various human tissues.” 2010. Doctoral Dissertation, University of Oulu. Accessed March 07, 2021. http://urn.fi/urn:isbn:9789514262449.

MLA Handbook (7^th Edition):

Eriksen, H (Heidi). “Carboxyterminal telopeptide structures of type I collagen in various human tissues.” 2010. Web. 07 Mar 2021.

Vancouver:

Eriksen H(. Carboxyterminal telopeptide structures of type I collagen in various human tissues. [Internet] [Doctoral dissertation]. University of Oulu; 2010. [cited 2021 Mar 07]. Available from: http://urn.fi/urn:isbn:9789514262449.

Council of Science Editors:

Eriksen H(. Carboxyterminal telopeptide structures of type I collagen in various human tissues. [Doctoral Dissertation]. University of Oulu; 2010. Available from: http://urn.fi/urn:isbn:9789514262449

29. Sad, Pedro P. Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Aortic Valve Stenosis: a Systematic Review.

Degree: MS, Department of Public Health Sciences, 2015, University of Alberta

URL: https://era.library.ualberta.ca/files/n870zt77b

► Introduction: Aortic stenosis (AS) is the most common form of heart valve disease in the western world. As the population ages, this disease is becoming… (more)

▼ Introduction: Aortic stenosis (AS) is the most common form of heart valve disease in the western world. As the population ages, this disease is becoming an increasing burden on patients and on the health care system. Current drug therapies (medical management (MM)) cannot reverse the course of AS. For most individuals with severe AS, surgical aortic valve replacement (SAVR), which requires open heart surgery and cardiopulmonary bypass, remains the standard therapy. However, a sub-group of patients with aortic stenosis are unsuitable for or at high risk to undergo SAVR due to their frailty or other comorbidities. Transcatheter aortic valve implantation (TAVI) - a novel, less invasive treatment option – was developed as an alternative for patients who are not suitable or at high risk for undergoing surgery. Objective: This study is intended to assess the feasibility, safety, efficacy and clinical effectiveness of TAVI, using the transfemoral (TF) and transapical (TA) approaches, in comparison to medical management or SAVR in patients with severe symptomatic AS; and to compare the outcomes associated with the two different approaches for valve implantation (TF and TA). Methods: A comprehensive literature search was conducted using eight electronic databases to identify studies of TAVI (TF and/or TA) for the treatment of AS. Data from the selected studies were extracted by two reviewers. Outcomes considered were feasibility, safety, efficacy and effectiveness of TAVI. Study quality was assessed and information was tabulated to identify trends or patterns. Results were pooled across studies for each outcome. Results: Fifty six relevant studies were identified: 37 studies (including seven comparative studies) assessed clinical outcomes, 14 studies discussed health-related quality of life, and five studies examined the impact of the learning curve on feasibility and safety of TAVI on patient outcomes. The overall procedural success rate was 96% (88% - 100%). Studies that examined the learning curve for TAVI demonstrated it had a significant impact - increasing the procedural success rate and decreasing 30-day mortality. The mean combined periprocedural and cumulative all-cause mortality rate at 30 days for TAVI compared to the control groups (MM and/or SAVR) in the same or different studies was: 9.0%, n = 10,500 vs 2.8%, n = 179, and 6.7%, n = 302, respectively. Permanent pacemaker implantation was three times more common with the Medtronic CoreValve compared to the Edwards SAPIEN prosthesis (26.5% vs 8.2%), but when both TAVI valves were compared with SAVR, there was no statistically significant difference. Major vascular complications occurred more frequently in the TF group (11.6%) than in the MM, SAVR or the TA groups. The rate of acute kidney injury requiring renal replacement therapy did not differ significantly between the TAVI and control groups, but was three times higher with the TA compared to the TF approach (7.3% vs 2.5%). TAVI achieved significant hemodynamic improvement as measured by echocardiography. The…

Subjects/Keywords: aortic; severe; symptomatic; stenosis

…1 1.1 Overview of aortic stenosis (AS)… …2 1.1.3 Natural course of aortic stenosis… …150 Figures Figure 1. Aortic stenosis etiology: morphology of a normal, rheumatic, calcific… …2 Figure 2. Natural course of aortic valve stenosis without treatment… …75 Tables Table 1. Grading the severity of aortic stenosis in adults…

4 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sad, P. P. (2015). Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Aortic Valve Stenosis: a Systematic Review. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/n870zt77b

Chicago Manual of Style (16^th Edition):

Sad, Pedro P. “Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Aortic Valve Stenosis: a Systematic Review.” 2015. Masters Thesis, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/n870zt77b.

MLA Handbook (7^th Edition):

Sad, Pedro P. “Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Aortic Valve Stenosis: a Systematic Review.” 2015. Web. 07 Mar 2021.

Vancouver:

Sad PP. Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Aortic Valve Stenosis: a Systematic Review. [Internet] [Masters thesis]. University of Alberta; 2015. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/n870zt77b.

Council of Science Editors:

Sad PP. Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Aortic Valve Stenosis: a Systematic Review. [Masters Thesis]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/n870zt77b

30. Stathogiannis, Konstantinos. Μελέτη θερμικής ετερογένειας σε αθηρωματικές πλάκες καρωτίδων με τη μέθοδο της ακτινομετρίας μικροκυμάτων (microwave radiometry): συσχέτιση με υπερηχογραφικά και ιστολογικά ευρήματα.

Degree: 2015, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/41442

►

Background. Studies have shown that human atheromatic carotid plaques emit heatand it is possible to measure in vivo the temperature by special catheters. Microwaveradiometry (MR)… (more)

▼

Background. Studies have shown that human atheromatic carotid plaques emit heatand it is possible to measure in vivo the temperature by special catheters. Microwaveradiometry (MR) is a novel diagnostic technique and is based on measuring tissuetemperature by detecting the natural electromagnetic radiation in microwavefrequency. It has been used already in experimental models with success.Aim. In the present study MR was used for the first time in human carotid arteries inorder to measure the temperature and correlate it with the ultrasound and histologicalfindings.Methods. Patients that were scheduled for endarterectomy (n=34) underwent fullscreening for carotid artery atherosclerosis with carotid ultrasound and MR. Healthyvolunteers were assigned as the control group (n=15). The ultrasound analysisinvolved detecting the type of plaque, its surface and echogenicity. The temperaturedifference (ΔΤ) was assigned as the maximal minus the minimum temperature alongthe carotid artery length. Correlation of the MR, ultrasound and histological resultswas performed.Results. Atheromatic plaques had a higher ΔΤ compared to control group (p < 0.01).Fatty plaques had a higher ΔΤ compared to mixed and calcified plaques (p < 0.01).Ulcerated plaques had a higher ΔΤ compared to plaques with regular or irregularsurface (p < 0.01). Heterogenous plaques had a higher ΔΤ compared to homogenousplaques (p < 0.01). Histological specimens with thin fibrous cap and increasedexpression of CD3, CD68 and vascular endothelial growth factor (VEGF) had higherΔΤ compared to specimens with thick fibrous cap and decreased expression of CD3,CD68 and VEGF (p < 0.01). Conclusions. Microwave radiometry can safely detect the in vivo temperature ofhuman carotids reflecting the inflammatory activation of atheromatic plaques.

Υπόβαθρο. Μελέτες έχουν δείξει ότι εκλύεται θερμότητα από τις αθηρωματικές καρωτίδες των ανθρώπων και ότι είναι δυνατή η in vivo μέτρηση της θερμοκρασίας με ειδικούς καθετήρες. Η ακτινομετρία μικροκυμάτων (ΑΜ) αποτελεί μια νέα,αναπτυσσόμενη διαγνωστική τεχνική η οποία βασίζεται στη μέτρηση της θερμοκρασίας των ιστών του οργανισμού, εκτιμώντας τη φυσική ηλεκτρομαγνητική ακτινοβολία σε συχνότητες μικροκυμάτων, ενώ ήδη η τεχνική αυτή χρησιμοποιήθηκεεπιτυχώς για τη μέτρηση της θερμοκρασίας των αθηρωματικών πλακών σε πειραματόζωα. Σκοπός. Στην παρούσα μελέτη χρησιμοποιήθηκε για πρώτη φορά η ΑΜ σε ανθρώπινες αθηρωματικές καρωτίδες, ώστε να μελετηθεί η in vivo μέτρηση της θερμοκρασίας και να διευρευνηθεί εάν η θερμοκρασία συσχετίζεται με τα αντίστοιχα υπερηχογραφικά και ιστολογικά ευρήματα.Μέθοδοι. Ασθενείς οι οποίοι ήταν προγραμματισμένοι για ενδαρτηρεκτομή (n=34)υποβλήθηκαν σε πλήρη έλεγχο των καρωτίδων με υπέρηχο και μέτρηση με ΑΜ. Ως ομάδα ελέγχου (n=15) εντάχθηκαν υγιείς εθελοντές. Η υπερηχογραφική μελέτη περιελάμβανε ανάλυση του τύπου της πλάκας, της επιφανείας της και της ηχογένειας της. Η διαφορά θερμοκρασίας (ΔΤ) κατά τη μέτρηση με την ΑΜ ορίστηκε ως η μεγίστη μείον την ελάχιστη θερμοκρασία κατά μήκος της καρωτίδας. Στη συνέχεια έγινε…

Subjects/Keywords: Ακτινομετρία Μικροκυμάτων; Στένωση καρωτίδων; ΑΕΕ; Microwave radiometry; Carotid artery stenosis; CVA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stathogiannis, K. (2015). Μελέτη θερμικής ετερογένειας σε αθηρωματικές πλάκες καρωτίδων με τη μέθοδο της ακτινομετρίας μικροκυμάτων (microwave radiometry): συσχέτιση με υπερηχογραφικά και ιστολογικά ευρήματα. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/41442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stathogiannis, Konstantinos. “Μελέτη θερμικής ετερογένειας σε αθηρωματικές πλάκες καρωτίδων με τη μέθοδο της ακτινομετρίας μικροκυμάτων (microwave radiometry): συσχέτιση με υπερηχογραφικά και ιστολογικά ευρήματα.” 2015. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 07, 2021. http://hdl.handle.net/10442/hedi/41442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stathogiannis, Konstantinos. “Μελέτη θερμικής ετερογένειας σε αθηρωματικές πλάκες καρωτίδων με τη μέθοδο της ακτινομετρίας μικροκυμάτων (microwave radiometry): συσχέτιση με υπερηχογραφικά και ιστολογικά ευρήματα.” 2015. Web. 07 Mar 2021.

Vancouver:

Stathogiannis K. Μελέτη θερμικής ετερογένειας σε αθηρωματικές πλάκες καρωτίδων με τη μέθοδο της ακτινομετρίας μικροκυμάτων (microwave radiometry): συσχέτιση με υπερηχογραφικά και ιστολογικά ευρήματα. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10442/hedi/41442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stathogiannis K. Μελέτη θερμικής ετερογένειας σε αθηρωματικές πλάκες καρωτίδων με τη μέθοδο της ακτινομετρίας μικροκυμάτων (microwave radiometry): συσχέτιση με υπερηχογραφικά και ιστολογικά ευρήματα. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. Available from: http://hdl.handle.net/10442/hedi/41442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations