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1.
Elisandra Do Nascimento, Graziele.
Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais
.
Degree: 2011, Universidade Federal de Pernambuco
URL: http://repositorio.ufpe.br/handle/123456789/6173 
► A corrosão por ácidos naftênicos a altas temperaturas nas unidades de refino é um dos maiores problemas nas refinarias de todo o mundo, uma vez…
(more)
▼ A corrosão por ácidos naftênicos a altas temperaturas nas unidades de refino é um dos
maiores problemas nas refinarias de todo o mundo, uma vez que, podem causar
envenenamento de catalisadores e paradas operacionais de alto custo. Os ácidos naftênicos
correspondem a uma mistura complexa de ácidos carboxílicos presentes no petróleo,
responsáveis diretamente pela sua acidez e corrosividade. Tais compostos também estão
presentes nas frações destiladas do petróleo, causando diversos problemas na qualidade final
do produto. Dentre estas frações do petróleo pode-se destacar o querosene de aviação (QAV)
que é produzido através do fracionamento por destilação à pressão atmosférica. Os óleos
nacionais estão cada vez mais ácidos, estimulando a busca por novos e eficientes métodos de
mitigação. Métodos propostos por estudos científicos e industriais para minimizar a corrosão
provocada por ácidos naftênicos vêm apresentando custos elevados e problemas de operação.
O processo de adsorção tem a vantagem da possibilidade de recuperação dos ácidos
orgânicos, que são precursores de surfactantes e aditivos para lubrificantes, não havendo
formação de resíduos poluentes e contribuindo com o meio ambiente. As peneiras
moleculares mesoporosas (MCM-41) vêm despertando grande interesse na comunidade
científica em função da perspectiva da sua aplicação em processos de adsorção e catálise. A
fim de reduzir o alto custo dos processos de separação por adsorção, principalmente devido ao
elevado valor de alguns adsorventes, a utilização de resíduos agroindustriais como
adsorventes vem se destacando como método alternativo. O objetivo deste trabalho foi a
remoção da acidez naftênica de uma mistura modelo de QAV (ácido dodecanóico em ndodecano)
com uso do adsorvente
Sr-MCM-41 e de adsorvente preparado a partir de resíduo
agroindustrial. No presente trabalho foi sintetizada a peneira molecular mesoporosa
Sr-MCM-
41, na qual a incorporação do estrôncio resultou no aumento da basicidade do material e
consequentemente da sua afinidade pelos ácidos. O adsorvente
Sr-MCM-41 foi caracterizado
por análise termogravimétrica (TG) e termogravimétrica diferencial (DTG), difração de raios-
X (DRX), medida de área superficial por adsorção de N2 (BET), espectrometria de emissão
óptica com plasma indutivamente acoplado (ICP-OES) e espectroscopia na região do
infravermelho com transformada de Fourier (FT-IR). Os resultados da caracterização deste
material indicaram que a incorporação do estrôncio não comprometeu a estrutura mesoporosa
e que os materiais sintetizados apresentaram um bom grau de organização. Foi utilizada a
técnica de planejamento fatorial para otimização do processo adsortivo visando a
determinação das melhores condições de operação. Em seguida foram realizados estudos de
cinética e equilíbrio de adsorção com o adsorvente
Sr-MCM-41, obtendo-se como capacidade
máxima adsortiva 2,0 gácido.g-1
adsorvente, a partir do estudo de equilíbrio de adsorção. Os dados
de equilíbrio foram ajustados a isoterma de BET tipo IV. A…
Advisors/Committee Members: Maria Bezerra De Menezes, Celmy (advisor).
Subjects/Keywords: Sr-MCM-41;
Adsorção;
QAV
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APA (6th Edition):
Elisandra Do Nascimento, G. (2011). Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais
. (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/6173
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Elisandra Do Nascimento, Graziele. “Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais
.” 2011. Thesis, Universidade Federal de Pernambuco. Accessed January 23, 2020.
http://repositorio.ufpe.br/handle/123456789/6173.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Elisandra Do Nascimento, Graziele. “Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais
.” 2011. Web. 23 Jan 2020.
Vancouver:
Elisandra Do Nascimento G. Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais
. [Internet] [Thesis]. Universidade Federal de Pernambuco; 2011. [cited 2020 Jan 23].
Available from: http://repositorio.ufpe.br/handle/123456789/6173.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Elisandra Do Nascimento G. Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais
. [Thesis]. Universidade Federal de Pernambuco; 2011. Available from: http://repositorio.ufpe.br/handle/123456789/6173
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
McMaster University
2.
Aljarallah, Aishah.
INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI.
Degree: PhD, 2011, McMaster University
URL: http://hdl.handle.net/11375/11437
► High density lipoprotein (HDL) is an independent risk factor for thedevelopment of coronary heart disease. HDL mediated reverse cholesterol transport is a key element…
(more)
▼ High density lipoprotein (HDL) is an independent risk factor for thedevelopment of coronary heart disease. HDL mediated reverse cholesterol transport is a key element responsible for the cardioprotective effects of HDL. In addition HDL exerts other atheroprotective effects in vascular cells. The HDL receptor, scavenger receptor class I type B (SR-BI) derives the process of reverse cholesterol transport, mediates HDL signaling in the vasculature and protects against atherosclerosis. However, the exact atheroprotective mechanisms of HDL and SR-BI are not clearly understood.This thesis starts by characterizing a model of occlusive coronary arteryatherosclerosis, the SR-BI/apolipoprotein E double knockout mice and tests the effectsof phenolic rich pomegranate extract on disease progression. Coronary artery disease in these mice starts at three weeks of age and progresses rapidly leading to sudden death within three to five weeks. The administration of pomegranate extract reduced the extent of coronary artery atherosclerosis possibly via mechanisms that involved alterations in lipid metabolism and reduced inflammation and oxidative stress.The next two chapters aimed to gain better understanding of the atheroprotectiveactions of HDL and SR-BI. Increased macrophage apoptosis is a key event in the development of atherosclerotic plaques. HDL signaling via SR-BI reduced macrophage apoptosis while the lack of macrophage SR-BI was associated with increased macrophage apoptosis and necrotic core areas, features of plaque instability. Next HDL and SR-BI effects on macrophage migration, a key event in atherosclerotic plaque regression, are described. HDL stimulated the migration of macrophages in a manner that was dependent on SR-BI, its adaptor protein, PDZK1, and the G-protein coupled receptor, sphingosine-1-phosphate receptor 1. SR-BI mediated macrophage migration may suggest a potential role of SR-BI in atherosclerotic plaque regression.To expand our view of HDL effects on macrophages we have used proteomics as an approach. HDL treatment of macrophages altered the expression of multiple proteins.Validation experiment confirmed changes in interesting and particularly relevant protein targets in HDL mediated protection against macrophage apoptosis and inflammation and in HDL induced macrophage migration. Follow up experiments will determine their involvement in HDL and SR-BI mediated signaling. Overall this work represents a milestone in understanding the atheroprotective effects of HDL and SR-BI in macrophages.
Doctor of Philosophy (PhD)
Advisors/Committee Members: Trigatti, Bernardo, Geoff Werstuck and Joseph Macri, Geoff Werstuck and Joseph Macri, Biochemistry.
Subjects/Keywords: HDL; SR-BI; Macrophages; Signaling
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APA (6th Edition):
Aljarallah, A. (2011). INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/11437
Chicago Manual of Style (16th Edition):
Aljarallah, Aishah. “INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI.” 2011. Doctoral Dissertation, McMaster University. Accessed January 23, 2020.
http://hdl.handle.net/11375/11437.
MLA Handbook (7th Edition):
Aljarallah, Aishah. “INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI.” 2011. Web. 23 Jan 2020.
Vancouver:
Aljarallah A. INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI. [Internet] [Doctoral dissertation]. McMaster University; 2011. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/11375/11437.
Council of Science Editors:
Aljarallah A. INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI. [Doctoral Dissertation]. McMaster University; 2011. Available from: http://hdl.handle.net/11375/11437
University of Waterloo
3.
Hall, Karlee.
Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle.
Degree: 2011, University of Waterloo
URL: http://hdl.handle.net/10012/6144
► The purpose of this study was to investigate whether skeletal muscle sarcoplasmic reticulum (SR) Ca2+ transport efficiency and expression levels of major SR Ca2+ regulatory…
(more)
▼ The purpose of this study was to investigate whether skeletal muscle sarcoplasmic reticulum (SR) Ca2+ transport efficiency and expression levels of major SR Ca2+ regulatory proteins are associated with resting metabolic rate (RMR) in humans. Twenty five healthy and weight stable participants with mean age, height and weight of 22±3.6 years, 174.6±8.0 cm and 72.8±21 kg respectively, were recruited for the study. RMR was calculated using the Weir equation based upon measures of VO2 and VCO2, which were collected using the Vmax breath by breath indirect calorimetry system. Ca2+-ATPase activity, Ca2+ uptake and Ca2+ leak analyses were performed in vitro on homogenates that were prepared from vastus lateralis muscle biopsies. Ionophore (IONO) ratio was assessed by measuring Ca2+-ATPase activity in the presence and absence of Ca2+ Ionophore. The coupling ratio, a measure of SR Ca2+ transport efficiency, was calculated by taking the ratio of Ca2+ uptake to Ca2+-ATPase activity. Expression levels of the major SR Ca2+ regulatory proteins, including SERCA1a, SERCA2a, phospholamban (PLN), and calsequestrin (CSQ) were assessed using Western blotting techniques. Pearson correlation coefficient analysis demonstrated a weak but significant negative correlation between coupling ratio and RMR (r2= 0.2108, p =0.0240). Content of the SR Ca2+ regulatory proteins, IONO ratio and Ca2+ leak were not found to be significantly related to either RMR or coupling ratio, with the exception of the ratio of SERCA1a to SERCA2a, which showed a weak but significant positive relationship with RMR (r2=0.1781, p=0.0400). Thus, the relationship between coupling ratio and RMR is not influenced by Ca2+ leak, SERCA pump efficiency or the SR Ca2+ regulatory proteins. Overall, these results suggest that the efficiency of SR Ca2+ transport is weakly related to whole body RMR. Further analysis is needed to assess this relationship, and to determine which SR Ca2+ handling properties are influencing the relationship between coupling ratio and RMR.
Subjects/Keywords: RMR; SR Ca2+ transport efficiency
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APA ·
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CSE |
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Manager
APA (6th Edition):
Hall, K. (2011). Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/6144
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hall, Karlee. “Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle.” 2011. Thesis, University of Waterloo. Accessed January 23, 2020.
http://hdl.handle.net/10012/6144.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hall, Karlee. “Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle.” 2011. Web. 23 Jan 2020.
Vancouver:
Hall K. Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle. [Internet] [Thesis]. University of Waterloo; 2011. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/10012/6144.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hall K. Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle. [Thesis]. University of Waterloo; 2011. Available from: http://hdl.handle.net/10012/6144
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
Santos, Priscila Ribeiro dos.
A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio.
Degree: Mestrado, Física, 2008, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/
;
► Esta dissertação de mestrado descreve o estudo realizado sobre como a oferta de estrôncio afeta a razão Sr/Ca em hidroxiapatita formada in vitro. Este trabalho…
(more)
▼ Esta dissertação de mestrado descreve o estudo realizado sobre como a oferta de estrôncio afeta a razão Sr/Ca em hidroxiapatita formada in vitro. Este trabalho pretende dar subsídios para que posteriormente seja possível fazer um estudo da razão Sr/Ca em função da temperatura também em hidroxiapatita formada in vitro. Foram utilizadas células osteoblásticas da linhagem MG-63 com concentrações de estrôncio no meio de cultura que variaram de 0,0 até 33,0 microgramas por mL de meio. Os nódulos ósseos formados pelas células foram caracterizados pelas técnicas Absorção de Infravermelho por Transformada de Fourier (FT-IR), que foi utilizada com o objetivo de identificar ligações de fosfato nas amostras, e Difração de Raios-X (XRD), que teve como objetivo confirmar a presença de hidroxiapatita nos minerais formados e comparar a cristalinidade do material com e sem estrôncio. A quantificação da razão Sr/Ca foi feita utilizando as técnicas Retro-espalhamento Rutherford (RBS) e Emissão de Raios-X por Indução de Partículas (PIXE), que são capazes de fazer a identificação e quantificação elementar. Os resultados obtidos mostram que os nódulos formados são compostos por hidroxiapatita. Com relação à quantificação, mostrou-se que não foi possível substituir mais de 10% do íons de cálcio por íons de estrôncio, o que está de acordo com previsões teóricas. Além disso, para altas concentrações de estrôncio no meio a mineralização do cálcio diminuiu duas ordens de grandeza e as medidas da razão Sr/Ca obtiveram resultados bastante dispersos, indicando uma possível mudança metabólica das células que parece inviabilizar o bom funcionamento fisiológico das mesmas.
This Masters dissertation describes the study of how the availability of strontium affects Sr/Ca ratio of in vitro hydroxyapatite. This work intends to provide the basic understanding needed to a future study of how temperature changes Sr/Ca ratio in this material. MG-63 cells were grown in the culture medium doped with 0.0, 1.0, 2.0, 4.1, 8.2, 16.4, 22.9 and 33.0 micrograms of Sr/mL. The nodules formed by osteoblastic cells were characterized by Fourier Transform Infrared Spectroscopy (FT-IR) technique, used to identify phosphate domain, and X-Ray Diffraction (XRD) technique, which was used to verify the presence of crystallized hydroxyapatite in the mineral composition with and without strontium. Quantification of Sr/Ca ratio was made using the Rutherford Backscattering (RBS) and Particle Induced X-Ray Emission (PIXE) techniques, which are used to do elementary identification and quantification. The results of characterization confirmed the presence of hydroxyapatite in the cultivated MG-63 cells. The experiments have shown that it was not possible to replace more than 10% of the calcium ions by strontium, which is consistent with theoretical predictions. In addition, high concentrations of strontium in the growing solution, reduced the mineralization yield and also the Sr/Ca ratio, indicating a possible change in the metabolism of the cells.
Advisors/Committee Members: Added, Nemitala.
Subjects/Keywords: hidroxiapatita; hydroxyapatite; PIXE; PIXE; Sr/Ca; Sr/Ca; XRD; XRD
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APA (6th Edition):
Santos, P. R. d. (2008). A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;
Chicago Manual of Style (16th Edition):
Santos, Priscila Ribeiro dos. “A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio.” 2008. Masters Thesis, University of São Paulo. Accessed January 23, 2020.
http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;.
MLA Handbook (7th Edition):
Santos, Priscila Ribeiro dos. “A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio.” 2008. Web. 23 Jan 2020.
Vancouver:
Santos PRd. A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2020 Jan 23].
Available from: http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;.
Council of Science Editors:
Santos PRd. A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;
University of Vienna
5.
Maronova, Monika.
Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens.
Degree: 2017, University of Vienna
URL: http://othes.univie.ac.at/48522/
► Alternatives Spleißen (AS) ist ein hochregulierter Prozess, der mehrere mRNAVarianten aus einem einzigen Gen erzeugt und zur Transkriptom- und Proteom-Diversität und Feinabstimmung der Genexpression in…
(more)
▼ Alternatives Spleißen (AS) ist ein hochregulierter Prozess, der mehrere mRNAVarianten aus einem einzigen Gen erzeugt und zur Transkriptom- und Proteom-Diversität und Feinabstimmung der Genexpression in höheren Eukaryoten wesentlich beiträgt. Einer der Hauptakteure in AS sind SR-Proteine, eine Familie von evolutionär konservierten Spleißfaktoren. Arabidopsis-Genom kodiert achtzehn SR-Proteine und ihre Regulierung und exakte Funktionen sind unklar. Um eine komplexe Regulierung von AS zu sezieren, ist es von großer Wichtigkeit, die Veränderungen in AS unter bestimmten Bedingungen präzise zu überwachen, aber solche Methoden sind in Pflanzen nicht gut etabliert. Die vorliegende Arbeit beschreibt die Entwicklung und Anwendung eines neuartigen hochauflösenden (HR) RT-PCR-Screens, um Veränderungen in mehreren bekannten AS-Ereignissen unter den gewünschten Bedingungen und genetischen Hintergründen zu messen. Das System erwies sich als reproduzierbar, präzise und auch in der Lage, neuartige AS-Transkripte zu erkennen. Während meiner Dissertation konzentrierte ich mich auf ein pflanzenspezifisches SRProtein At-RS31. HR-RT-PCR-Screen-Analyse der At-RS31-Überexpression (ÜE) Linie zeigte an, dass At-RS31 AS von Genen, die beteiligen sich am RNA-Metabolismus und Spleißen, Transkription und DNA-Reparatur, moduliert. Interessanterweise beeinflusste ÜE von At-RS31 das Spleißmuster des DNA-Reparaturgens UVH1/ATRAD1 und ähnlich wie bei uvh1 Mutanten waren At-RS31- ÜE -Pflanzen gegenüber der UV-C-Exposition überempfindlich. Erhöhte Levels von At-RS31 verschärfte Effekte von mehreren anderen abiotischen Belastungen und förderten eine frühe Seneszenz, was auf eine wichtige Rolle und eine enge Regulierung der At-RS31-Expression für das Überleben der Pflanzen in wechselnder Umgebung hindeutet. Die Kenntnis der in Arabidopsis gewonnenen Pflanzen-SR-Gene wurde durch das Studium des Moos Physcomitrella patens ergänzt. Obwohl evolutionärer entfernter Organismus, besitzt Physcomitrella SR-Gene mit hoch konservierter Struktur und AS zu Arabidopsis. Die Charakterisierung von AS in drei orthologen SR-Genen enthüllte ein extensives Spleißen im langen Intron von Pp-RS27 und mehrfache Spleißvarianten von zwei Genen der Pp-RS2Z-Subfamilie. Bemerkenswerterweise zeigte die Analyse von ASVarianten unter verschiedenen Wachstumsbedingungen, dass AS von Pp-RS27
Veränderungen in Reaktion auf UV-C und Licht gegenüber Dunkel zeigt, ähnlich die Beobachtungen in seinem Orthologe At-RS31, was auf einen hoch konservierten Mechanismus zur Regulierung von AS in Antwort auf externe Anregungen.
Alternative splicing (AS) is a highly regulated process that generates multiple mRNA variants from a single gene and contributes greatly to the transcriptome and proteome diversity and fine tuning of gene expression in higher eukaryotes. One of the key players in AS are SR proteins, a family of evolutionary conserved splicing factors. Arabidopsis genome encodes eighteen SR proteins and their regulation and exact functions are unclear. To dissect complex regulation of AS it…
Subjects/Keywords: 42.13 Molekularbiologie; Alternatives Spleissen / SR Proteine; alternative splicing / SR proteins
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APA ·
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Manager
APA (6th Edition):
Maronova, M. (2017). Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/48522/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Maronova, Monika. “Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens.” 2017. Thesis, University of Vienna. Accessed January 23, 2020.
http://othes.univie.ac.at/48522/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Maronova, Monika. “Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens.” 2017. Web. 23 Jan 2020.
Vancouver:
Maronova M. Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens. [Internet] [Thesis]. University of Vienna; 2017. [cited 2020 Jan 23].
Available from: http://othes.univie.ac.at/48522/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Maronova M. Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens. [Thesis]. University of Vienna; 2017. Available from: http://othes.univie.ac.at/48522/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Trad, Georges.
Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring.
Degree: Docteur es, Physique subatomique et astroparticules, 2015, Grenoble Alpes
URL: http://www.theses.fr/2015GREAY005
► La mesure de l’émittance transverse du faisceau est fondamentale pour tous les accélérateurs, et en particulier pour les collisionneurs, son évaluation precise étant essentielle pour…
(more)
▼ La mesure de l’émittance transverse du faisceau est fondamentale pour tous les accélérateurs, et en particulier pour les collisionneurs, son évaluation precise étant essentielle pour maximiser la luminosité et ainsi la performance des faisceaux de collision.Le rayonnement synchrotron (
SR) est un outil polyvalent pour le diagnostic non-destructif de faisceau, exploité au CERN pour mesurer la taille des faisceaux de protons des deux machines du complexe dont l’énergie est la plus élevée, le SPS et le LHC où l’intensité du faisceau ne permet plus les techniques invasives.Le travail de thèse documenté dans ce rapport s’est concentré sur la conception, le développement, la caractérisation et l’optimisation des moniteurs de taille de faisceau basés sur le
SR. Cette étude est fondée sur un ensemble de calculs théoriques, de simulation numériques et d’expériences conduite au sein des laboratoires et accélérateurs du CERN. Un outil de simulation puissant a été développé, combinant des logiciels classiques de simulation de
SR et de propagation optique, permettant ainsi la caractérisation complète d’un moniteur
SR de la source jusqu’au détecteur.La source
SR a pu être entièrement caractérisée par cette technique, puis les résultats validés par observation directe et par la calibration à basse énergie basée sur les mesures effectuées avec les wire-scanners (WS), qui sont la référence en terme de mesure de taille de faisceau, ou telles que la comparaison directe avec la taille des faisceaux obtenue par déconvolution de la luminosité instantanée du LHC.Avec l’augmentation de l’énergie dans le LHC (7TeV), le faisceau verra sa taille diminuer jusqu’à atteindre la limite de la technique d’imagerie du
SR. Ainsi, plusieurs solutions ont été investiguées afin d’améliorer la performance du système: la sélection d’une des deux polarisations du
SR, la réduction des effets liés à la profondeur de champ par l’utilisation de fentes optiques et l’utilisation d’une longueur d’onde réduite à 250 nm.En parallèle à l’effort de réduction de la diffraction optique, le miroir d’extraction du
SR qui s’était avéré être la source principale des aberrations du système a été entièrement reconçu. En effet, la détérioration du miroir a été causée par son couplage EM avec les champs du faisceau, ce qui a conduit à une surchauffe du coating et à sa dégradation. Une nouvelle géométrie de miroir et de son support permettant une douce transition en termes de couplage d’impédance longitudinale dans le beam pipe a été définie et caractérisée par la technique dite du “streched wire”. Egalement, comme méthode alternative à l’imagerie directe, un nouveau moniteur basé sur la technique d’interférométrie à deux fentes du
SR, non limité par la diffraction, a également été développé. Le principe de cette méthode est basé sur la relation directe entre la visibilité des franges d’interférence et la taille de faisceau.Comme l’emittance du faisceau est la donnée d’intérêt pour la performance du LHC, il est aussi important de caractériser avec précision l’optique du LHC à la…
Advisors/Committee Members: Conto, Jean-Marie de (thesis director), Roncarolo, Federico (thesis director).
Subjects/Keywords: LHC; Radiation de synchrotron; SR; Instrumentation des faisceaux; Profil transverse; Emittance; SR imagerie; Interferométrie; SR interférence; Impédance longitudinale; Modulation de quadrupoles; Optique; Accélerateur; Accelerator; LHC; Synchrotron Radiation; SR; Beam Instrumentation; Beam size diagnostics; Emittance; SR imaging; Interferometry; K-Modulation; Machine optics measurement; 530
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APA (6th Edition):
Trad, G. (2015). Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring. (Doctoral Dissertation). Grenoble Alpes. Retrieved from http://www.theses.fr/2015GREAY005
Chicago Manual of Style (16th Edition):
Trad, Georges. “Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring.” 2015. Doctoral Dissertation, Grenoble Alpes. Accessed January 23, 2020.
http://www.theses.fr/2015GREAY005.
MLA Handbook (7th Edition):
Trad, Georges. “Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring.” 2015. Web. 23 Jan 2020.
Vancouver:
Trad G. Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring. [Internet] [Doctoral dissertation]. Grenoble Alpes; 2015. [cited 2020 Jan 23].
Available from: http://www.theses.fr/2015GREAY005.
Council of Science Editors:
Trad G. Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring. [Doctoral Dissertation]. Grenoble Alpes; 2015. Available from: http://www.theses.fr/2015GREAY005
Universidade do Estado do Rio de Janeiro
7.
Hugo Tavares Machado.
Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr.
Degree: Master, 2010, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289
;
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290
;
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291
;
► A área estudada está inserida na Faixa Ribeira, Segmento Central da Província Mantiqueira (Almeida et al., 1973, 1977, 1981), que representa um cinturão de dobramentos…
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▼ A área estudada está inserida na Faixa Ribeira, Segmento Central da Província Mantiqueira (Almeida et al., 1973, 1977, 1981), que representa um cinturão de dobramentos e empurrões gerado no Neo-proterozóico/Cambriano, durante a Orogênese Brasiliana, na borda sul/sudeste do Cráton do São Francisco (Almeida, 1971, 1977; Cordani et al., 1967, 1973; Cordani & Brito Neves, 1982; Teixeira & Figueiredo, 1991). Neste contexto, o Complexo Quirino é o embasamento retrabalhado do Terreno Paraíba do Sul (Heilbron et al., 2004). O Complexo Quirino é formado por extensos corpos de ortognaisses foliados a homogêneos, leuco a mesocráticos, de granulometria média à grossa, composicionalmente variando entre granitóides tonalíticos/granodioríticos a graníticos, e apresentando enclaves de rochas ultramáficas, máficas e cálcio-silicáticas (ricas em tremolita). Os ortognaisses tonalíticos/granodioríticos apresentam porfiroblastos de plagioclásio e a hornblenda como máfico principal, contrastando com os de composição granítica que apresentam porfiroblastos de K-feldspato e biotita predominante. Como acessórios aparecem zircão, titanita, apatita e epidoto. Também estão associados a estes ortognaisses, granitóides neoproterozóicos que formam corpos individualizados ou lentes anatéticas no conjunto paleoproterozóico. Estes são compostos predominantemente por biotita gnaisse e hornblenda-biotita gnaisse. A análise litogeoquímicas dos ortognaisses do Complexo Quirino demonstrou a existência de duas séries magmáticas distintas. A primeira pertencente à série cálcio-alcalina de alto-K apresenta uma composição mais expandida granítica-adamelítica/granodioritica/tonalítica e é correlacionável aos bt-ortognaisses e alguns hb-bt-ortognaisses. Os ortognaisses da série médio-K apresentam composição predominantemente tonalítica, sendo correlacionáveis à maioria dos hornblenda-biotita gnaisses. Enclaves lenticulares de metapiroxeníticos e anfibolíticos ocorrem em muitos afloramentos. Também ocorrem granitóides neoproterozóicos de composição graníticas a quartzo-monzoníticas O estudo isotópico de Sm-Nd e
Sr demonstrou que os ortognaisses da série cálcio-alcalina de alto-K e aqueles da série cálcio-alcalina de médio-K possuem idades modelo TDM variando entre paleoproterozóicas a arqueanas, consistentes com dados U-Pb em zircão publicados na literatura. A série cálcio-alcalina de alto-K é mais antiga (2308 9,2 Ma a 2185 8 Ma) do que a série calcio-alcalina de médio-K (2169 3 a 2136 14 Ma) e a existência de zircões herdados com idades mínimas de 2846 Ma e 2981 Ma para série de médio-K e 3388 16 para série de alto-K. Os granitóides brasilianos possuem idades de cristalização neoproterozóica correlacionada a Orogênese Brasiliana (602 a 627 Ma) (Viana, 2008; Valladares et al., 2002)./Com base nos dados de
Sr e Sm-Nd foi possível caracterizar 4 grupos distintos. Os grupos 1 e 2 são formados por rochas de idade paleoproterozóica (2,1 a 2,3 Ga) com idades modelo TDM variando de 2,9 e 3,4 Ga, εNd entre -8,1 e -5,8 e 87Sr/86Sr(t) = 0,694707 (Grupo 1) e TDM…
Advisors/Committee Members: Claudio de Morisson Valeriano, Sílvia Regina de Medeiros, Rubem Porto Junior, Claudia Sayão Valladares.
Subjects/Keywords: Complexo Quirino; Geoquímica isotópica de Sm-Nd e Sr; Quirino Complex; Sm-Nd and Sr geochemistry; GEOQUIMICA
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APA (6th Edition):
Machado, H. T. (2010). Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;
Chicago Manual of Style (16th Edition):
Machado, Hugo Tavares. “Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr.” 2010. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed January 23, 2020.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;.
MLA Handbook (7th Edition):
Machado, Hugo Tavares. “Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr.” 2010. Web. 23 Jan 2020.
Vancouver:
Machado HT. Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2010. [cited 2020 Jan 23].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;.
Council of Science Editors:
Machado HT. Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2010. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;
Université de Montréal
8.
Miranda, Leonor.
Regulation of cholesterol intake by the corpus luteum
.
Degree: 2010, Université de Montréal
URL: http://hdl.handle.net/1866/3947
► Résumé L’approvisionnement en cholestérol est un facteur limitant la stéroïdogenèse ovarienne. Pour cette raison, la majorité du cholestérol requis pour la synthèse des stéroïdes est…
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▼ Résumé
L’approvisionnement en cholestérol est un facteur limitant la stéroïdogenèse ovarienne. Pour cette raison, la majorité du cholestérol requis pour la synthèse des stéroïdes est importé de la circulation via les récepteurs des lipoprotéines de haute (HDL) et de basse densité (LDL) nommés scavenger receptor (
SR-BI) et low-density lipoprotein receptor (LDLr). L’ARN messager de
SR-BI est exprimé dans les ovaires de porcs durant toutes les étapes de la folliculogenèse ainsi que dans le corps jaune (CL). L’expression de la protéine
SR-BI a également été détectée dans les follicules de souris lors du cycle œstral. Chez les deux espèces, l’expression est concentrée dans le cytoplasme et en périphérie des cellules du follicule. Les gonadotrophines induisent l'expression de
SR-BI dans les cellules de la granulosa porcines, avec une expression cytoplasmique qui augmente durant la période périovulatoire, et avec une migration aux périphéries cellulaires durant la maturation du CL. Une conformation de 82 kDa de
SR-BI est fortement exprimée dans le CL porcin, avec une conformation moins abondante de 57 kDa. Les différences entre les conformations sont attribuables à la glycosylation. La culture in vitro de follicules porcins avec des gonatrophines chorioniques humaines (hCG) a induit une hausse de régulation dépendante du temps du
SR-BI de 82 kDa dans les cellules du granulosa.
SR-BI et LDLr ont été exprimés réciproquement, avec LDLr étant le plus élévé dans les cellules folliculaires du granulosa et diminuant précipitamment avec la formation du CL. Pour explorer plus en détail les mécanismes d’approvisionnement en cholestérol de la stéroïdogenèse ovarienne, nous avons examiné des souris soumis à un traitement de désaccouplement de l'ovulation, et des souris portant la mutation nulle du gène Scarb1 (
SR-BI-/-). Les résultats ont démontré que des ovocytes enfermés dans des structures lutéinisées expriment
SR-BI. Les souris
SR-BI-/ - présentaient de petits CLs, et de large follicules avec des cellules de thèque hypertrophiées et des kystes folliculaires avec des cavités remplies de sang et une diminution de 50% du niveau de progestérone dans le sérum. Les souris
SR-BI-/ - traitées avec une combinaison de 20 g / g de mevinoline et 100 g / g de chloroquine ont démontré une diminution de 43% du niveau de progestérone sérique chez le type sauvage et de 30% chez les souris
SR-BI-/ -. L’expression protéique de l’enzyme limitant pour la synthèse du cholestérol, 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR), a augmenté chez les souris
SR-BI-/-. Nous avons présenté des preuves démontrant que les cellules des follicules expriment le
SR-BI durant la stéroïdogenèse et que la lutéinisation augmente l’expression de
SR-BI. La maturation post-transcriptionelle est caractérisée par la glycosylation. Sous des conditions normales, l’expression de LDLr est arrêtée durant la lutéinisation. Ainsi
SR-BI devient le facteur principal pour l’importation du cholestérol extracellulaire. En plus, la perturbation extracellulaire du cholestérol…
Advisors/Committee Members: Murphy, Bruce D (advisor).
Subjects/Keywords: Ovary;
Ovaire;
Follicle;
Follicule;
Corpus luteum;
Corp jaune;
Cholesterol;
Cholésterol;
SR-BI;
SR-BI;
Lipoprotein receptors;
Récepteurs de lipoprotéines
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APA ·
Chicago ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Miranda, L. (2010). Regulation of cholesterol intake by the corpus luteum
. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/3947
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Miranda, Leonor. “Regulation of cholesterol intake by the corpus luteum
.” 2010. Thesis, Université de Montréal. Accessed January 23, 2020.
http://hdl.handle.net/1866/3947.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Miranda, Leonor. “Regulation of cholesterol intake by the corpus luteum
.” 2010. Web. 23 Jan 2020.
Vancouver:
Miranda L. Regulation of cholesterol intake by the corpus luteum
. [Internet] [Thesis]. Université de Montréal; 2010. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/1866/3947.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Miranda L. Regulation of cholesterol intake by the corpus luteum
. [Thesis]. Université de Montréal; 2010. Available from: http://hdl.handle.net/1866/3947
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
9.
Hesari, Mahdi.
Electrogenerated Chemiluminescence of Gold Nanoclusters.
Degree: 2014, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/2200
► A series of monodispersed AuNCs including Au144(SR)60, Au38(SR)24 and Au25(SR)18z (z =1-, 0 and 1+, SR=2-phenylethanethiol) were prepared. All these nanoclusters showed molecule-like optical and…
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▼ A series of monodispersed AuNCs including Au144(SR)60, Au38(SR)24 and Au25(SR)18z (z =1-, 0 and 1+, SR=2-phenylethanethiol) were prepared. All these nanoclusters showed molecule-like optical and electrochemical properties. These two features are essential for an electrogenerated chemiluminescence or electrochemiluminescence (ECL) study. The Au144(SR)60 showed a small HOMO-LUMO gap determined by electrochemistry. No ECL light was seen in the annihilation process, while NIR ECL was observed with tri-n- propylamine (TPrA) (Chapter 2). ECL was highly efficient in the Au38(SR)24/TPrA co- reactant system. This nanocluster also showed ECL emission with benzoyl peroxide (BPO), while no ECL was detected in the annihilation route (Chapter 3). The ECL of Au25(SR)18z (z =1-, 0 and 1+) were discovered to emit NIR ECL light in the presence of either TPrA or BPO co-reactant. The Au25(SR)18+/ TPrA system revealed the strongest ECL emission among the three Au25 oxidation states (Chapter 4). The thermodynamic (Latimer-type diagram) and the kinetic origins of Au25(SR)180 ECL were explored in the presence of TPrA (Chapter 5). And lastly, the NIR ECL of Au25(SR)18− nanoclusters was mechanistically investigated in the presence of both TPrA and BPO with NIR emissions in both systems (Chapter 6).
In each case a multiple ECL emissions were observed. The ECL peak wavelength and ECL intensity can be tuned by means of both the co-reactant concentration and applied electrode potential. It is worth noting that the Au38(SR)24 showed the strongest ECL efficiency among all the clusters studied, and the Au25(SR)18z clusters possessed a rich photoelectrochemistry leading to highly efficient ECL.
Subjects/Keywords: Electrochemistry; Electrogenerted chemiluminescence (ECL); Spooling ECL and PL spectroscopy; Gold nanoclusters; Au25(SR)18; Au38(SR)24.; Analytical Chemistry; Materials Chemistry
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hesari, M. (2014). Electrogenerated Chemiluminescence of Gold Nanoclusters. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2200
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hesari, Mahdi. “Electrogenerated Chemiluminescence of Gold Nanoclusters.” 2014. Thesis, University of Western Ontario. Accessed January 23, 2020.
https://ir.lib.uwo.ca/etd/2200.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hesari, Mahdi. “Electrogenerated Chemiluminescence of Gold Nanoclusters.” 2014. Web. 23 Jan 2020.
Vancouver:
Hesari M. Electrogenerated Chemiluminescence of Gold Nanoclusters. [Internet] [Thesis]. University of Western Ontario; 2014. [cited 2020 Jan 23].
Available from: https://ir.lib.uwo.ca/etd/2200.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hesari M. Electrogenerated Chemiluminescence of Gold Nanoclusters. [Thesis]. University of Western Ontario; 2014. Available from: https://ir.lib.uwo.ca/etd/2200
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université Montpellier II
10.
Lopez Mejia, Isabel Cristina.
Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford.
Degree: Docteur es, Biologie Santé, 2011, Université Montpellier II
URL: http://www.theses.fr/2011MON20077
► Le vieillissement est un processus complexe qui peut être influencé par des facteurs environnementaux et génétiques. Le syndrome progéroïde de Hutchinson-Gilford (HGPS ou progéria) fourni…
(more)
▼ Le vieillissement est un processus complexe qui peut être influencé par des facteurs environnementaux et génétiques. Le syndrome progéroïde de Hutchinson-Gilford (HGPS ou progéria) fourni une preuve irréfutable de l'implication de l'épissage dans le processus de vieillissement. La progéria est une maladie due à une mutation hétérozygote silencieuse qui renforce l'utilisation d'un site 5' d'épissage interne dans l'exon 11 de l'ARN pré-messager LMNA, ce qui entraîne la production d'une protéine tronquée appelée «progérine». Le défaut d'épissage du gène LMNA a aussi lieu dans les cellules de personnes âgées, et la correction de ce défaut permet un sauvetage partiel des anomalies qu'il provoque. Ceci fait de l'ARN pré-messager LMNA une cible très attractive pour des thérapies ayant pour but de corriger l'épissage. Mes travaux de thèse ont montré que cette mutation silencieuse active un site d'épissage 5' dans l'exon 11 en changeant la structure de l'ARN. Ce changement de structure facilite l'interaction de la snRNP U1 avec le site d'épissage et permet ainsi sa modulation par les protéines SR SRSF1 et SRSF6. J'ai aussi participé à la caractérisation d'un nouveau modèle murin qui reproduit l'altération d'épissage des patients HGPS au niveau du gène Lmna souris. De façon surprenante, ce modèle récapitule tous les phénotypes du syndrome HGPS. Les souris homozygotes, dans lesquelles la plupart de la lamine A est convertie en progérine, ne vivent pas plus de 5 mois, alors que les souris hétérozygotes vivent autour d'un an et que les contrôles sauvages vivent deux ans. Étonnamment, des souris qui n'expriment ni la lamine A ni la progérine, mais uniquement de la lamine C, vivent plus longtemps que les souris contrôle, suggérant que la lamine A et la progérine, qui sont produites à partir du même transcrit, participent à la régulation de la durée de la vie. De plus, la caractérisation initiale des souris HGPS indique que l'expression de la progérine est délétère pour le tissu adipeux, établissant ainsi un lien inattendu entre l'épuisement du tissu adipeux et le vieillissement accéléré. Ce nouveau modèle murin est actuellement en train d'être utilisé pour des approches de modulation de l'épissage aberrant du gène LMNA avec des oligonucléotides antisense et des petites molécules chimiques.
Aging is a complex cellular and organismal process that can be influenced by environmental as well as genetic factors. A striking proof-of-concept that splicing regulation plays an important role in the aging process is provided by Hutchinson-Gilford progeria syndrome (HGPS), a disease caused by a heterozygous silent mutation that enhances the use of an internal 5' splice site in exon 11 of LMNA pre-mRNA and leads to the production of a truncated protein called “progerin”. The LMNA splicing defect also occurs with increased frequency in cells from healthy aged individuals and correction of this defect leads to partial reversal of age-related dysfunction. This makes LMNA pre-mRNA an attractive target for splicing-correction therapies. During my…
Advisors/Committee Members: Tazi, Jamal (thesis director).
Subjects/Keywords: Epissage alternatif; Proteines SR; Syndrome progéroïde de Hutchinson-Gilford; Vieillissement; Lmna; Alternative splicing; SR proteins; Hutchinson-Gilford Progeria Syndrome; Aging; Lmna
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APA ·
Chicago ·
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Manager
APA (6th Edition):
Lopez Mejia, I. C. (2011). Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford. (Doctoral Dissertation). Université Montpellier II. Retrieved from http://www.theses.fr/2011MON20077
Chicago Manual of Style (16th Edition):
Lopez Mejia, Isabel Cristina. “Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford.” 2011. Doctoral Dissertation, Université Montpellier II. Accessed January 23, 2020.
http://www.theses.fr/2011MON20077.
MLA Handbook (7th Edition):
Lopez Mejia, Isabel Cristina. “Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford.” 2011. Web. 23 Jan 2020.
Vancouver:
Lopez Mejia IC. Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford. [Internet] [Doctoral dissertation]. Université Montpellier II; 2011. [cited 2020 Jan 23].
Available from: http://www.theses.fr/2011MON20077.
Council of Science Editors:
Lopez Mejia IC. Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford. [Doctoral Dissertation]. Université Montpellier II; 2011. Available from: http://www.theses.fr/2011MON20077
11.
Juillard, Franceline.
Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20.
Degree: Docteur es, Sciences de la vie, 2011, Lyon, École normale supérieure
URL: http://www.theses.fr/2011ENSL0621
► La protéine EB2 du virus d'Epstein-Barr (EBV) est une protéine du cycle réplicatif du virus indispensable à la production de particules virales. Elle permet l’accumulation…
(more)
▼ La protéine EB2 du virus d'Epstein-Barr (EBV) est une protéine du cycle réplicatif du virus indispensable à la production de particules virales. Elle permet l’accumulation dans le cytoplasme de certains ARNm viraux issus de gènes dépourvus d’intron. Pour mettre en évidence les mécanismes qui permettent à EB2 d’exporter ses ARNm cibles dans le cytoplasme, nous avons identifié différents partenaires cellulaires d’EB2 et nous avons étudié certaines de ces interactions d’un point de vue fonctionnel. Nous avons pu montrer qu’EB2 recrute directement le facteur général d'export des ARNm, TAP/NXF1, ce qui lui permet d’être exportée du noyau vers le cytoplasme. Puis nous avons montré qu’EB2 interagit avec SRp20, une protéine impliquée notamment dans la régulation de l'épissage et l'export des ARNm cellulaires. Cette interaction entre EB2 et SRp20 est indispensable pour l’accumulation dans le cytoplasme de certains ARNm cibles d’EB2, notamment parce que SRp20 semble permettre le recrutement d'EB2 sur ces ARNm. Enfin, nous avons montré qu’EB2 forme un dimère et nous avons caractérisé le domaine de la protéine responsable de cette interaction. La dimérisation d'EB2 semble essentielle pour que la protéine interagisse avec certains de ses partenaires comme SRp20 ou encore REF.
The Epstein-Barr virus (EBV) protein EB2 is an early protein essential for the production of infectous virions. EB2 allows the cytoplasmic accumulation of a subset of viral mRNAs derived from intronless genes. To highlight the mecanisms by which EB2 exports his targets mRNA, we identified cellular partners and studied the functional role of some of these interactions. We showed that EB2 recruits directly the cellular mRNA export factor TAP/NXF1 and this interaction allows EB2’s shuttling between the nucleus and the cytoplasm. The we showed that EB2 interacts with SRp20, a cellular protein implicated in splicing regulation and mRNA export. This interaction is essential for the efficient cytoplasmic accumulation of some EB2 target mRNAs, partly because SRp20 appears to be able to recruit EB2 on these mRNAs. Then we showed that EB2 dimerises and we characterized the domain necessary for this interaction. This dimerisation appears to be essential for EB2’s interaction with several partners, including SRp20 and REF.
Advisors/Committee Members: Gruffat, Henri (thesis director).
Subjects/Keywords: Export des ARNm; TAP/NXF1; Protéines SR; SRp20; MRNAs export; TAP/NXF1; SR protein; SRp20; Epstein-Barr Virus
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APA (6th Edition):
Juillard, F. (2011). Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20. (Doctoral Dissertation). Lyon, École normale supérieure. Retrieved from http://www.theses.fr/2011ENSL0621
Chicago Manual of Style (16th Edition):
Juillard, Franceline. “Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20.” 2011. Doctoral Dissertation, Lyon, École normale supérieure. Accessed January 23, 2020.
http://www.theses.fr/2011ENSL0621.
MLA Handbook (7th Edition):
Juillard, Franceline. “Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20.” 2011. Web. 23 Jan 2020.
Vancouver:
Juillard F. Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20. [Internet] [Doctoral dissertation]. Lyon, École normale supérieure; 2011. [cited 2020 Jan 23].
Available from: http://www.theses.fr/2011ENSL0621.
Council of Science Editors:
Juillard F. Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20. [Doctoral Dissertation]. Lyon, École normale supérieure; 2011. Available from: http://www.theses.fr/2011ENSL0621
12.
Amor, Souheila.
Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease.
Degree: Docteur es, Sciences de la vie, spécialité Virologie, 2010, Université François-Rabelais de Tours
URL: http://www.theses.fr/2010TOUR4045
► La télomérase, composée de l‘ARN TR et de la protéine TERT, responsable du maintien de la longueur des télomères est surexprimée dans la majorité des…
(more)
▼ La télomérase, composée de l‘ARN TR et de la protéine TERT, responsable du maintien de la longueur des télomères est surexprimée dans la majorité des cellules cancéreuses. La dynamique de la régulation post-transcriptionnelle de TERT sur l‘activation de la télomérase a été étudiée dans le modèle de lymphomagenèse induite par l‘herpesvirus oncogène aviaire de la maladie de Marek. L‘augmentation de l‘activité télomérase des TCD4+ lors de l‘apparition des lymphomes résulte d‘une hausse du transcrit constitutif et de celle des transcrits cibles de la voie de dégradation du « non-sense mediated decay » (NMD) alors que l‘activité télomérase basale des TCD4+ non infectés est contrôlée par les isoformes dominantes négatives. La caractérisation de la protéine virale ICP27 de MDV-1, régulateur potentiel de l‘épissage des gènes, qui s‘exprime pendant la phase de réplication lytique du virus a complété cette étude. ICP27 est capable de co-localiser et d‘interagir avec les protéines SR du splicéosome ainsi que de réguler négativement l‘épissage des gènes cellulaire TERT et viral vIL8 de manière similaire à ICP27 de l‘herpesvirus simplex 1. Le modèle naturel de lymphomagenèse induite par MDV-1 a permis d‘établir pour la première fois un lien entre l‘activation de la télomérase in vivo et la régulation de l‘épissage de TERT, à laquelle pourrait participer la protéine virale ICP27.
The telomerase, consisting of an RNA template (TR) and a reverse transcriptase (TERT) maintains telomere length and is highly expressed in the majority of cancer cells. The splicing regulation of TERT was studied in Marek‘s disease (MD), a natural lymphoma induced by MDV-1, the avian MD herpesvirus. Telomerase activation observed in TCD4+ cells at the onset of MD lymphoma was due to an increase of constitutively spliced and « non-sense mediated decay » (NMD) while basal telomerase activity of non infected TCD4+ cells was controlled by dominant negative isoforms. In addition, the viral protein ICP27, a putative regulator of splicing, expressed during MDV-1 lytic infection was characterised. ICP27 co-localized and interacted with spliceosome SR proteins and negatively controlled splicing of TERT and vIL8 viral gene in a way similar to that of ICP27 of herpesvirus simplex 1. The MD model provides the only data on the in vivo regulation of TERT splicing, possibly mediated by ICP27, and telomerase activation during lymphomagenesis induced by a herpesvirus in its natural host.
Advisors/Committee Members: Laurent, Sylvie (thesis director).
Subjects/Keywords: Herpesvirus; Maladie de Marek; Oncogenèse; Épissage; NMD; Télomérase; ICP27; Protéines SR; Herpesvirus; Marek Disease; Oncogenesis; Splicing; NMD; Telomerase; ICP27; SR proteins
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APA ·
Chicago ·
MLA ·
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CSE |
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APA (6th Edition):
Amor, S. (2010). Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease. (Doctoral Dissertation). Université François-Rabelais de Tours. Retrieved from http://www.theses.fr/2010TOUR4045
Chicago Manual of Style (16th Edition):
Amor, Souheila. “Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease.” 2010. Doctoral Dissertation, Université François-Rabelais de Tours. Accessed January 23, 2020.
http://www.theses.fr/2010TOUR4045.
MLA Handbook (7th Edition):
Amor, Souheila. “Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease.” 2010. Web. 23 Jan 2020.
Vancouver:
Amor S. Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease. [Internet] [Doctoral dissertation]. Université François-Rabelais de Tours; 2010. [cited 2020 Jan 23].
Available from: http://www.theses.fr/2010TOUR4045.
Council of Science Editors:
Amor S. Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease. [Doctoral Dissertation]. Université François-Rabelais de Tours; 2010. Available from: http://www.theses.fr/2010TOUR4045
Université Montpellier II
13.
Fernando, Céline.
Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster.
Degree: Docteur es, Biologie Santé, 2011, Université Montpellier II
URL: http://www.theses.fr/2011MON20197
► Les protéines SR, qui constituent une famille conservée de facteurs liant l'ARN, jouent un rôle majeur dans l'épissage des ARN et en particulier dans la…
(more)
▼ Les protéines SR, qui constituent une famille conservée de facteurs liant l'ARN, jouent un rôle majeur dans l'épissage des ARN et en particulier dans la régulation de l'épissage alternatif. Certaines protéines SR peuvent également participer à l'élongation de la transcription, l'export, la stabilité ou la traduction des ARNm. Ces différents rôles soulignent l'importance des protéines SR en tant que régulateurs clés du métabolisme des ARNm et de l'expression des gènes. Des altérations de leur quantité ou de leur activité peuvent induire des défauts développementaux ou des pathologies telles que des tumeurs. Afin de mieux comprendre les fonctions et les mécanismes de régulation des protéines SR in vivo, je me suis intéressée à la protéine SR B52 chez D. melanogaster. En réalisant un crible génétique, nous avons identifié des protéines capables de sauver les phénotypes induits par la surexpression de B52 in vivo. L'une de ces protéines est l'ADN Topoisomérase I (Topo I). La Topo I possède à la fois une activité topoisomérase impliquée dans la relaxation de l'ADN, et une activité kinase capable de phosphoryler les protéines SR. Nous avons montré que B52 est impliquée dans le recrutement de la Topo I aux sites actifs de transcription, en particulier lors de l'induction des gènes heat shock, et que ces protéines jouent un rôle dans la libération de l'ARN hsp70 de son site de transcription et dans l'extinction de sa transcription. Une autre protéine capable de sauver les phénotypes induits par la surexpression de B52 est Brain tumor, un répresseur post-transcriptionnel de l'expression de myc. Myc est un régulateur clé de la croissance chez la drosophile. Nos résultats révèlent un effet positif de B52 sur la croissance cellulaire dans certains tissus, et sur l'expression de dmyc. Nous montrons également que le niveau de B52 affecte l'épissage alternatif de plusieurs gènes impliqués dans la croissance, dont le coactivateur transcriptionnel Yorkie et le facteur d'initiation de la traduction eIF4E. Ainsi, nos travaux suggèrent que la protéine SR B52 pourrait coordonner un ensemble d'évènements d'épissage dans des voies de signalisation impliquées dans la croissance cellulaire.
SR proteins, which constitute a conserved family of RNA-binding factors, play a key role in RNA splicing and particularly in alternative splicing regulation. In addition, some SR proteins have been shown to participate in transcription elongation, mRNA export, mRNA stability and mRNA translation. These wide-ranging roles of SR proteins highlight their importance as pivotal regulators of mRNA metabolism and gene expression. Alteration of their expression level or activity can induce developmental defects or pathologies such as tumors. To better understand SR proteins functions and how they are regulated in vivo, I studied a major SR protein in Drosophila melanogaster called B52. Using a genetic screen, we identified proteins that can rescue the phenotypes induced by B52 overexpression. Among them is the DNA Topoisomerase I (Topo I). Topo I carries two…
Advisors/Committee Members: Tazi, Jamal (thesis director).
Subjects/Keywords: Protéines SR; Épissage alternatif; Drosophile; Topoisomérase I; Croissance cellulaire; SR proteins; Alternative splicing; Drosophila melanogaster; Topoisomerase I; Cell growth
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APA ·
Chicago ·
MLA ·
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CSE |
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APA (6th Edition):
Fernando, C. (2011). Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster. (Doctoral Dissertation). Université Montpellier II. Retrieved from http://www.theses.fr/2011MON20197
Chicago Manual of Style (16th Edition):
Fernando, Céline. “Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster.” 2011. Doctoral Dissertation, Université Montpellier II. Accessed January 23, 2020.
http://www.theses.fr/2011MON20197.
MLA Handbook (7th Edition):
Fernando, Céline. “Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster.” 2011. Web. 23 Jan 2020.
Vancouver:
Fernando C. Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster. [Internet] [Doctoral dissertation]. Université Montpellier II; 2011. [cited 2020 Jan 23].
Available from: http://www.theses.fr/2011MON20197.
Council of Science Editors:
Fernando C. Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster. [Doctoral Dissertation]. Université Montpellier II; 2011. Available from: http://www.theses.fr/2011MON20197
Vilnius Gediminas Technical University
14.
Stasionytė,
Rita.
Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR
alternatyvaus splaisingo reguliacija.
Degree: Master, Biochemistry, 2009, Vilnius Gediminas Technical University
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555
;
► Baigiamojo magistro darbo tyrimo objektas – pelės HIF-3α baltymą koduojantis genas ir jo pre-iRNR alternatyvaus splaisingo procesas. Darbe pristatomas alternatyvaus HIF-3α pre-iRNR splaisingo reguliacijos tyrimas,…
(more)
▼ Baigiamojo magistro darbo tyrimo objektas –
pelės HIF-3α baltymą koduojantis genas ir jo pre-iRNR alternatyvaus
splaisingo procesas. Darbe pristatomas alternatyvaus HIF-3α
pre-iRNR splaisingo reguliacijos tyrimas, atliekant pre-iRNR
splaisingo reakcijas in vitro HeLa ląstelių branduolių
ekstraktuose. Nustatyta, kad hipoksinėmis sąlygomis augintų HeLa
ląstelių branduolių ekstrakte alternatyvūs 3ʹ splaisingo taikiniai
splaisingo metu naudojami neefektyviai lyginant su jų panaudojimu
normoksinėmis sąlygomis augintų HeLa ląstelių branduolių ekstrakte.
Ištirta SR baltymų įtaka alternatyvaus HIF-3α pre-iRNR splaisingo
procesui ir nustatyta, kad SR baltymų funkcinis aktyvumas kinta
priklausomai nuo deguonies kiekio ląstelinėje aplinkoje. Palyginus
U2AF65 splaisingo faktoriaus kiekį hipoksinėmis ir normoksinėmis
sąlygomis augintų HeLa ląstelių branduolių ekstraktuose, nustatyta,
kad šio baltymo kiekis sumažėja hipoksinėmis sąlygomis. Atlikti
tyrimai yra svarbūs suprantant priklausomai nuo deguonies kiekio
aplinkoje ląstelėje vykstančius pokyčius pre-iRNR splaisingo
lygmenyje, kuriant naujus vėžinių auglių gydymo metodus ir
atrandant naujus vėžinius žymenis.
The object of this final work was mouse
hypoxia inducible factor - 3α gene and its pre-mRNA alternative
splicing process. During the course of the work alternative
pre-mRNA splicing regulation of HIF-3α was investigated. In vitro
reactions of pre-mRNA splicing were performed in under normoxic or
hypoxic oxygen conditions cultivated HeLa cells nuclear extracts.
There was found that in hypoxic HeLa cells nuclear extract
alternative 3ʹ splice sites are used ineffectively compared with
their usage in normoxic HeLa cells nuclear extract. The influence
of SR proteins purified from HeLa cells on alternative HIF-3α
pre-mRNA splicing was investigated. There was found that functional
activity of SR proteins varies depending on oxygen tension in
cellural environment. Also there was determined that amount of
U2AF65 splicing factor in HeLa cells nuclear extracts is reduced by
hypoxia. These investigations and results are important trying to
understand the complex cell response to hypoxia, control pre-mRNA
splicing changes processed under hypoxic conditions, create new
methods for solid tumours treatment.
Advisors/Committee Members: Kanopka, Arvydas (Master’s thesis supervisor), Gedminienė, Genovaitė (Master’s thesis advisor), Sereikaitė, Jolanta (Master’s thesis reviewer).
Subjects/Keywords: Alternatyvus
splaisingas; Hipoksija; Hipoksijos indukuojami
faktoriai; Pre-iRNR; SR baltymai; Alternative
splicing; Hypoxia; Hypoxia inducible
factors; Pre-mRNA; SR proteins
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stasionytė,
Rita. (2009). Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR
alternatyvaus splaisingo reguliacija. (Masters Thesis). Vilnius Gediminas Technical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Chicago Manual of Style (16th Edition):
Stasionytė,
Rita. “Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR
alternatyvaus splaisingo reguliacija.” 2009. Masters Thesis, Vilnius Gediminas Technical University. Accessed January 23, 2020.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
MLA Handbook (7th Edition):
Stasionytė,
Rita. “Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR
alternatyvaus splaisingo reguliacija.” 2009. Web. 23 Jan 2020.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
Stasionytė,
Rita. Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR
alternatyvaus splaisingo reguliacija. [Internet] [Masters thesis]. Vilnius Gediminas Technical University; 2009. [cited 2020 Jan 23].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Council of Science Editors:
Stasionytė,
Rita. Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR
alternatyvaus splaisingo reguliacija. [Masters Thesis]. Vilnius Gediminas Technical University; 2009. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Brno University of Technology
15.
Stránský, Jakub.
Protismykové vlastnosti vozovek
.
Degree: 2013, Brno University of Technology
URL: http://hdl.handle.net/11012/28908
► Bakalářská práce má za cíl zpracování poznatků o protismykových vlastnostech, jejich měření, zařízení k tomu sloužící a poruchy a jejich vhodné opravy u tuhých a…
(more)
▼ Bakalářská práce má za cíl zpracování poznatků o protismykových vlastnostech, jejich měření, zařízení k tomu sloužící a poruchy a jejich vhodné opravy u tuhých a netuhých vozovek. Praktická část vyhodnocuje protismykové vlastnosti vybraných dálničních úseků s tuhým i netuhým krytem na základě naměřených hodnot PTV.; Bachelor’s thesis main purpose is to process the knowledge about skid resistance, its mesurement, the equipment used and its failures and suitable repairs of solid and nonsolid roadways. The practical part evaluates skid resistance properities of selected highway sections with solid and nonsolid surface on the basis of measured values of PTV.
Advisors/Committee Members: Hýzl, Petr (advisor).
Subjects/Keywords: Protismykové vlastnosti;
mikrotextura;
makrotextura;
povrch vozovky;
ztráta PVV;
obnova PVV;
Skid resistance;
mircotexture;
macrotexture;
road surface;
loss of SR;
renewal SR
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MLA ·
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APA (6th Edition):
Stránský, J. (2013). Protismykové vlastnosti vozovek
. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/28908
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stránský, Jakub. “Protismykové vlastnosti vozovek
.” 2013. Thesis, Brno University of Technology. Accessed January 23, 2020.
http://hdl.handle.net/11012/28908.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stránský, Jakub. “Protismykové vlastnosti vozovek
.” 2013. Web. 23 Jan 2020.
Vancouver:
Stránský J. Protismykové vlastnosti vozovek
. [Internet] [Thesis]. Brno University of Technology; 2013. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/11012/28908.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stránský J. Protismykové vlastnosti vozovek
. [Thesis]. Brno University of Technology; 2013. Available from: http://hdl.handle.net/11012/28908
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Virginia Commonwealth University
16.
Bajpai, Saurabh.
ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII.
Degree: MS, Physiology, 2009, Virginia Commonwealth University
URL: https://scholarscompass.vcu.edu/etd/1711
► Reduction of cholesterol ester (CE) from lipid burden lesion-associated macrophage foam cells has been shown to reduce plaque volumes. Hydrolysis of CE to free cholesterol…
(more)
▼ Reduction of cholesterol ester (CE) from lipid burden lesion-associated macrophage foam cells has been shown to reduce plaque volumes. Hydrolysis of CE to free cholesterol (FC) in macrophages is an essential step for removal of CE from the macrophage and its transport to the liver by high density lipoprotein (HDL) for further metabolism. Since CE must again be hydrolyzed into FC in the liver catalyzing this hydrolysis, it becomes imperative to find the identity of these enzymes. In this study the role of key enzyme in catalyzing the hydrolysis of CE to FC, neutral cholesterol ester hydrolase (CEH) was evaluated. Further, ability of this CEH to hydrolyze CE delivered via scavenger receptor BI (
SR-BI) or
SR-BII was also monitored. CE hydrolysis and FC efflux were monitored from cells transfected with CEH expression vector. No significant difference was noted in either the intracellular CEH activity or FC efflux between cells transfected with an empty vector or a CEH expression vector. Further no difference was seen when experiments were repeated with cells stably transfected with
SR-BI or
SR-BII. Future experiments with more optimization of the cells system used will be required to reach any conclusions on the role of CEH in hydrolyzing HDL-CE delivered via
SR-BI/BII.
Advisors/Committee Members: Shobha Ghosh.
Subjects/Keywords: CEH; SR-BI; SR-BII; atherosclerosis; Life Sciences; Physiology
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APA (6th Edition):
Bajpai, S. (2009). ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII. (Thesis). Virginia Commonwealth University. Retrieved from https://scholarscompass.vcu.edu/etd/1711
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bajpai, Saurabh. “ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII.” 2009. Thesis, Virginia Commonwealth University. Accessed January 23, 2020.
https://scholarscompass.vcu.edu/etd/1711.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bajpai, Saurabh. “ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII.” 2009. Web. 23 Jan 2020.
Vancouver:
Bajpai S. ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII. [Internet] [Thesis]. Virginia Commonwealth University; 2009. [cited 2020 Jan 23].
Available from: https://scholarscompass.vcu.edu/etd/1711.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bajpai S. ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII. [Thesis]. Virginia Commonwealth University; 2009. Available from: https://scholarscompass.vcu.edu/etd/1711
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Brno University of Technology
17.
Hamáčková, Martina.
Analýza legend map tematických atlasů
.
Degree: 2013, Brno University of Technology
URL: http://hdl.handle.net/11012/29460
► Diplomová práce se zabývá analýzou legend map Atlasu krajiny České republiky a Atlasu krajiny Slovenskej republiky s důrazem na jejich vzájemné porovnání. Vychází z publikovaných…
(more)
▼ Diplomová práce se zabývá analýzou legend map Atlasu krajiny České republiky a Atlasu krajiny Slovenskej republiky s důrazem na jejich vzájemné porovnání. Vychází z publikovaných obecných teoretických zásad kartografické tvorby. Teoretickou část uzavírá kapitola, která se zevrubně zabývá legendou, jejími druhy, postupy při její tvorbě aj. Poté je s využitím objektivních kartografických kritérií provedena kritická analýza a klasifikace legend map Atlasu krajiny ČR a následně jejich porovnání s legendami Atlasu krajiny
SR. Je sledována především celková srozumitelnost, úplnost, grafické vyjádření a v neposlední řadě celkový vzhled legendy.; This diploma thesis is occupied with analysis of the keys to the maps of Landscape Atlas of the Czech Republic and the Landscape Atlas of the Slovak Republic with emphasis on their mutual comparison. This thesis based on the published general theoretical principles of cartographic production. The theoretical part concludes with a chapter that engages in the key in detail, its types, procedures, etc. Then come critical analysis and classification keys to the maps of Landscape Atlas of the CR and subsequent comparison with Landscape Atlas of the
SR using objective cartographic criteria. There is observed mainly the overall clarity, completeness, graphical representation and last but not least the overall look of the keys.
Advisors/Committee Members: Plánka, Ladislav (advisor).
Subjects/Keywords: Legenda;
znak;
Atlas krajiny ČR;
Atlas krajiny SR.;
Key;
mark;
Landscape Atlas of the CR;
Landscape Atlas of the SR.
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APA ·
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APA (6th Edition):
Hamáčková, M. (2013). Analýza legend map tematických atlasů
. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/29460
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hamáčková, Martina. “Analýza legend map tematických atlasů
.” 2013. Thesis, Brno University of Technology. Accessed January 23, 2020.
http://hdl.handle.net/11012/29460.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hamáčková, Martina. “Analýza legend map tematických atlasů
.” 2013. Web. 23 Jan 2020.
Vancouver:
Hamáčková M. Analýza legend map tematických atlasů
. [Internet] [Thesis]. Brno University of Technology; 2013. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/11012/29460.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hamáčková M. Analýza legend map tematických atlasů
. [Thesis]. Brno University of Technology; 2013. Available from: http://hdl.handle.net/11012/29460
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Michigan
18.
Marcano, Maria Carlota.
Interpretative Challenges and Opportunities in Oxygen and Strontium Isotope Compositions of Bivalve Shells.
Degree: PhD, Geology, 2010, University of Michigan
URL: http://hdl.handle.net/2027.42/77880
► Oxygen and strontium from biogenic carbonates (mostly bivalves) were used to evaluate paleoenvironmental interpretations on the basis of modern analogs along the North American east…
(more)
▼ Oxygen and strontium from biogenic carbonates (mostly bivalves) were used to evaluate paleoenvironmental interpretations on the basis of modern analogs along the North American east coast and to offer chronostratigraphic, paleoenvironmental, and diagenetic constraints to Neogene sequences from Southern McMurdo Sound, Antarctica. These are relevant pursuits in light of imminent climatic changes, which heighten the need for reliable paleoenvironmental interpretations and for data from climate–sensitive regions. In Vineyard Sound, Massachusetts, U.S.A., d18O from several coexisting shallow marine taxa and well–constrained environmental parameters were used to test the extent to which the known local annual variation of these parameters was represented in the shell carbonate. This relation was explored through the construction of time series from bivalve d18O versus shell distance profiles and the calculation of growth rates and isotopic fractionation factors. It was discovered that the marine temperature range recorded in the biogenic carbonate extended to lower temperatures than expected and was, in its entirety, better represented not by a single taxon but by the concurrent use of multiple taxa. Modeling of bivalve d18O of modern shallow marine environments along the North American east coast showed that large salinity ranges complicate environmental interpretations. However, modeled clams showed that d18O seasonal variability can discriminate between tropical and temperate shallow water marine climates. Higher variability characterizes the winter of tropical zones while the opposite is true for temperate regions. 87Sr/86Sr and
Sr concentration of unaltered calcite bivalves from ANDRILL’s core AND–2A produced reliable ages and confirm contrasting marine climate conditions across the Middle Miocene of Southern McMurdo Sound, Antarctica. In contrast, seemingly unaltered aragonite shells invariably produced older than expected ages. Additional analyses of the aragonite shells and 87Sr/86Sr compositions of pore water were carried out to reconcile these results. d18O and
Sr concentrations of pore water and aragonites suggested that the anomalous ages are likely the result of early diagenetic alteration, even in the absence of mineralogical change.
Advisors/Committee Members: Lohmann, Kyger C. (committee member), Fisher, Daniel C. (committee member), Kling II, George W. (committee member), Mukasa, Samuel B. (committee member), O'Foighil, Diarmaid (committee member), Wilkinson, Bruce H. (committee member).
Subjects/Keywords: O-18/O-16; Shallow-water Environment; 87-Sr/86-Sr; Paleoenvironment; Geology and Earth Sciences; Science
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APA (6th Edition):
Marcano, M. C. (2010). Interpretative Challenges and Opportunities in Oxygen and Strontium Isotope Compositions of Bivalve Shells. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/77880
Chicago Manual of Style (16th Edition):
Marcano, Maria Carlota. “Interpretative Challenges and Opportunities in Oxygen and Strontium Isotope Compositions of Bivalve Shells.” 2010. Doctoral Dissertation, University of Michigan. Accessed January 23, 2020.
http://hdl.handle.net/2027.42/77880.
MLA Handbook (7th Edition):
Marcano, Maria Carlota. “Interpretative Challenges and Opportunities in Oxygen and Strontium Isotope Compositions of Bivalve Shells.” 2010. Web. 23 Jan 2020.
Vancouver:
Marcano MC. Interpretative Challenges and Opportunities in Oxygen and Strontium Isotope Compositions of Bivalve Shells. [Internet] [Doctoral dissertation]. University of Michigan; 2010. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/2027.42/77880.
Council of Science Editors:
Marcano MC. Interpretative Challenges and Opportunities in Oxygen and Strontium Isotope Compositions of Bivalve Shells. [Doctoral Dissertation]. University of Michigan; 2010. Available from: http://hdl.handle.net/2027.42/77880
19.
Espinosa Delgado, Sara.
Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development.
Degree: Docteur es, Physiopathologie, 2017, Université Toulouse III – Paul Sabatier
URL: http://www.theses.fr/2017TOU30053
► L’effet athéroprotecteur des Lipoprotéines de Haute Densité (HDL) est principalement attribué à leur rôle clé dans Transport Retour du Cholestérol (RCT), un processus par lequel…
(more)
▼ L’effet athéroprotecteur des Lipoprotéines de Haute Densité (HDL) est principalement attribué à leur rôle clé dans Transport Retour du Cholestérol (RCT), un processus par lequel le cholestérol excédentaire des cellules périphériques est capté par les particules HDL pour être amené au foie où il sera préférentiellement sécrété dans les voies biliaires, puis excrété dans les fèces. Deux voies indépendantes ont été identifiées comme étant impliquées dans l’endocytose hépatique du HDL. La première est la voie ecto-F1-ATPase/P2Y13 dans laquelle l’apoA-I (apolipoprotéine majoritaire des HDL) se lie à la F1-ATPase exprimé à la surface des hépatocytes (ecto-F1-ATPase) et stimule l’hydrolyse d’ATP en ADP. L’ADP ainsi généré active le récepteur purinergique P2Y13 pour stimuler l’endocytose de l’holoparticule HDL (protéines + lipides) via un troisième récepteur différent de
SR-BI. Les souris invalidées pour P2Y13 présentent une diminution des sécrétions de lipides biliaires accompagnée d’une diminution du RCT des macrophages vers les fèces sous régime normolipidique. Un régime riche en cholestérol (1.25% cholestérol) accentue ce phénotype. La voie
SR-BI, quant à elle, est responsable de la captation sélective du cholestérol estérifié des HDL par le foie. Les souris invalidées pour
SR-BI spécifiquement au niveau du foie (
SR-BI KOfoie) présentent une hypercholestérolémie principalement attribuée à une augmentation du HDL-C et développent des plaques d’athérosclérose sous régime hypercholestérolémique. Dans une étude récente, nous avons montré que l’invalidation de P2Y13 dans le modèle murin proathérogène apoE KO induit une augmentation du développement d’athérosclérose associée à une diminution des sécrétions de lipides biliaires et du RCT des macrophages vers les fèces. De plus, dans ces souris, l’expression hépatique transcriptionnelle et protéique de
SR-BI étaient fortement augmentées par rapport aux souris apoE KO, suggérant qu’un possible mécanisme de compensation pourrait exister entre les récepteurs P2Y13 et
SR-BI. L’objectif de ma thèse a été d’étudier la contribution respective des récepteur P2Y13 et
SR-BI dans le métabolisme du HDL-C et le développement de l’athérosclérose. Nous avons croisé des souris P2Y13 KO avec des souris
SR-BI KOfoie et nous avons obtenu des souris doublement invalidées (P2Y13 x
SR-BIfoie dKO). Le phénotype métabolique des souris dKO a été étudié sous régime normolipidique et hypercholestérolémique et le développement d’athérosclérose sous régime hypercholestérolémique. Par rapport aux souris sauvages, les souris dKO sous régime normolipidique, présentent une augmentation du cholestérol plasmatique similaire à celle observée chez les souris
SR-BI KOfoie, principalement imputable à une augmentation du HDL-C. Les souris dKO, mais pas les souris
SR-BI KO, montrent une diminution des sécrétions de lipides biliaires comparable à celle observée chez les souris P2Y13 KO. Ce phénotype métabolique observé chez les souris dKO est accentué sous régime hypercholestérolémique et est associé à une augmentation…
Advisors/Committee Members: Martinez, Laurent (thesis director), Lichtenstein, Laetitia (thesis director).
Subjects/Keywords: HDL; P2Y13; SR-BI; Transport retour du cholestérol; Athérosclérose; HDL; P2Y13; SR-BI; Reverse cholesterol transport; Atherosclerosis
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APA ·
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Export
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APA (6th Edition):
Espinosa Delgado, S. (2017). Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2017TOU30053
Chicago Manual of Style (16th Edition):
Espinosa Delgado, Sara. “Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development.” 2017. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed January 23, 2020.
http://www.theses.fr/2017TOU30053.
MLA Handbook (7th Edition):
Espinosa Delgado, Sara. “Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development.” 2017. Web. 23 Jan 2020.
Vancouver:
Espinosa Delgado S. Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2017. [cited 2020 Jan 23].
Available from: http://www.theses.fr/2017TOU30053.
Council of Science Editors:
Espinosa Delgado S. Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2017. Available from: http://www.theses.fr/2017TOU30053
Temple University
20.
Seiple, Deborah Ann.
AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE.
Degree: PhD, 2016, Temple University
URL: http://digital.library.temple.edu/u?/p245801coll10,387690
► School Psychology
Executive function (EF) processes are crucial for meeting demands in the classroom. Because of this impact on schooling, it is important to have…
(more)
▼ School Psychology
Executive function (EF) processes are crucial for meeting demands in the classroom. Because of this impact on schooling, it is important to have tools that accurately measure EF in order to facilitate the identification of student needs and the development of interventions. This project assessed the concurrent, criterion-related validity of one of these tools, the Comprehensive Executive Functioning Inventory, Self-Report (CEFI-SR; Naglieri & Goldstein, 2013). This study correlated adolescents’ reports about their own behavior to scores derived from a direct measure of executive function to determine if teens were able to accurately rate their own EF abilities, indicating that the CEFI-SR had concurrent validity. Seventy-nine seventh and eighth grade students from a suburban middle school were recruited. The average age for the sample was 13 years and 10 months old, and 62% of the sample consisted of female students. Participants completed the CEFI-SR in small groups, and then, the lead examiner returned to the school to complete direct one-on-one testing with each student. Data were analyzed using Pearson product-moment correlations and t-tests. The t-tests were used to determine if significant differences between groups were present. Results from the t-tests indicated that there were no significant differences in performance across genders or grades. Additionally, no significant correlations were found between the rating scale scores and the results of the direct testing. These findings do not support the hypotheses that the CEFI-SR subscales would have moderate correlations with the direct testing scores from the NEPSY-II, indicating that the two measures may not be measuring the same constructs.
Temple University – Theses
Advisors/Committee Members: Fiorello, Catherine A.;, Farley, Frank, Thurman, Kenneth S., DuCette, Joseph P.;.
Subjects/Keywords: Educational psychology; Cognitive psychology;
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APA (6th Edition):
Seiple, D. A. (2016). AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,387690
Chicago Manual of Style (16th Edition):
Seiple, Deborah Ann. “AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE.” 2016. Doctoral Dissertation, Temple University. Accessed January 23, 2020.
http://digital.library.temple.edu/u?/p245801coll10,387690.
MLA Handbook (7th Edition):
Seiple, Deborah Ann. “AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE.” 2016. Web. 23 Jan 2020.
Vancouver:
Seiple DA. AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2020 Jan 23].
Available from: http://digital.library.temple.edu/u?/p245801coll10,387690.
Council of Science Editors:
Seiple DA. AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,387690
Texas Medical Center
21.
Wang, Shanzhi.
GENETIC INTERACTIONS OF FACTORS THAT REGULATE ALTERNATIVE RNA SPLICING IN THE MALE GERM LINE OF DROSOPHILA.
Degree: PhD, 2012, Texas Medical Center
URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/310
► Alternative RNA splicing is a critical process that contributes variety to protein functions, and further controls cell differentiation and normal development. Although it is…
(more)
▼ Alternative RNA splicing is a critical process that contributes variety to protein functions, and further controls cell differentiation and normal development. Although it is known that most eukaryotic genes produce multiple transcripts in which splice site selection is regulated, how RNA binding proteins cooperate to activate and repress specific splice sites is still poorly understood. In addition how the regulation of alternative splicing affects germ cell development is also not well known. In this study, Drosophila Transformer 2 (Tra2) was used as a model to explore both the mechanism of its repressive function on its own pre-mRNA splicing, and the effect of the splicing regulation on spermatogenesis in testis. Half-pint (Hfp), a protein known as splicing activator, was identified in an S2 cell-based RNAi screen as a co-repressor that functions in combination with Tra2 in the splicing repression of the M1 intron. Its repressive splicing function is found to be sequence specific and is dependent on both the weak 3’ splice site and an intronic splicing silencer within the M1 intron. In addition we found that in vivo, two forms of Hfp are expressed in a cell type specific manner. These alternative forms differ at their amino terminus affecting the presence of a region with four RS dipeptides. Using assays in Drosophila S2 cells, we determined that the alternative N terminal domain is necessary in repression. This difference is probably due to differential localization of the two isoforms in the nucleus and cytoplasm. Our in vivo studies show that both Hfp and Tra2 are required for normal spermatogenesis and cooperate in repression of M1 splicing in spermatocytes. But interestingly, Tra2 and Hfp antagonize each other’s function in regulating germline specific alternative splicing of Taf1 (TBP associated factor 1). Genetic and cytological studies showed that mutants of Hfp and Taf1 both cause similar defects in meiosis and spermatogenesis. These results suggest Hfp regulates normal spermatogenesis partially through the regulation of taf1 splicing. These observations indicate that Hfp regulates tra2 and taf1 activity and play an important role in germ cell differentiation of male flies.
Advisors/Committee Members: William W. Mattox, Michelle C. Barton, Thomas A. Cooper.
Subjects/Keywords: RNA SPLICING; SPERMATOGENESIS; DROSOPHILA; SR PROTEIN; Life Sciences; Molecular Genetics
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APA (6th Edition):
Wang, S. (2012). GENETIC INTERACTIONS OF FACTORS THAT REGULATE ALTERNATIVE RNA SPLICING IN THE MALE GERM LINE OF DROSOPHILA. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/310
Chicago Manual of Style (16th Edition):
Wang, Shanzhi. “GENETIC INTERACTIONS OF FACTORS THAT REGULATE ALTERNATIVE RNA SPLICING IN THE MALE GERM LINE OF DROSOPHILA.” 2012. Doctoral Dissertation, Texas Medical Center. Accessed January 23, 2020.
http://digitalcommons.library.tmc.edu/utgsbs_dissertations/310.
MLA Handbook (7th Edition):
Wang, Shanzhi. “GENETIC INTERACTIONS OF FACTORS THAT REGULATE ALTERNATIVE RNA SPLICING IN THE MALE GERM LINE OF DROSOPHILA.” 2012. Web. 23 Jan 2020.
Vancouver:
Wang S. GENETIC INTERACTIONS OF FACTORS THAT REGULATE ALTERNATIVE RNA SPLICING IN THE MALE GERM LINE OF DROSOPHILA. [Internet] [Doctoral dissertation]. Texas Medical Center; 2012. [cited 2020 Jan 23].
Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/310.
Council of Science Editors:
Wang S. GENETIC INTERACTIONS OF FACTORS THAT REGULATE ALTERNATIVE RNA SPLICING IN THE MALE GERM LINE OF DROSOPHILA. [Doctoral Dissertation]. Texas Medical Center; 2012. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/310
Victoria University of Wellington
22.
Korchinski, Megan S.
Ascent of Ultrahigh-Pressure Rocks in Southeastern
Papua New Guinea, as Revealed by Ti-in-Quartz
Thermometry and Rb-Sr Dating.
Degree: 2011, Victoria University of Wellington
URL: http://hdl.handle.net/10063/2023
► Debate concerns the timing of ultra-high pressure (UHP) metamorphism and the kinematics of exhumation of the world’s youngest known eclogite-facies rocks (U-Pb ages of 4…
(more)
▼ Debate concerns the timing of ultra-high pressure (UHP) metamorphism and the kinematics
of exhumation of the world’s youngest known eclogite-facies rocks (U-Pb ages of 4 – 8 Ma)
in the Woodlark Rift of southeastern Papua New Guinea. End-member kinematic models
that have been proposed for the crustal exhumation of metamorphic gneiss domes that host
these young eclogites include detachment-related (asymmetric) gneiss doming (metamorphic
core complexes), and pure shear-dominated (symmetric or diapiric) gneiss doming. The
former is predicted to exhume the deepest structural levels of the domes adjacent to a major
normal fault. The latter is predicted to yield a concentric pattern of exhumation levels with
the deepest rocks located near the center of the domes. As far as can be determined, there are
no mappable field gradients with respect to either the high-pressure metamorphism or the
later pervasive amphibolite-facies overprint in the lower crust. This apparent uniformity
contributes to uncertainty regarding the distribution of vertical strain in the body, and thus to
the mode of dome emplacement.
To delineate spatial differences in exhumation and cooling rates, I measured Ti content in
quartz for 90 samples of quartzofeldspathic gneiss and eclogite distributed across four
migmatitic gneiss domes using laser ablation inductively coupled plasma mass spectrometry.
I calculated paleo-temperatures from these data using the Ti-in-quartz geothermometer
(Thomas et al., 2010; Wark and Watson, 2006). The Ti concentration in quartz in these
samples ranges from 10 to 20 ppm, corresponding to an apparent temperature range of
500°C to 600°C (calculated using the Wark and Watson, 2006 calibration). As the apparent
temperatures do not have a clear correlation with lithology and the quartz grains exhibit
amoeboid grain boundaries, I infer that the Ti content in the quartz grains is capturing
information related to quartz recrystallization and grain growth during the final stages of
dynamic recrystallization by high-temperature grain-boundary migration (GBM). The
presence of pervasive partial melt in the rocks and of chessboard microstructures in the
quartz grains implies that the rocks in the D’Entrecasteaux Islands once attained
temperatures of >630°C; however the 93% of the apparent temperatures calculated here are
<630°C. Based on the pervasive GBM and the Ti-in-quartz apparent temperatures, I infer
that the mean Ti content in these quartz grains was chiefly dependent on the relative rates of
cooling and recrystallization as the body ascended through the crust. If the recrystallization
rate was less spatially variable relative to the cooling rates across the gneiss domes, more
quickly exhumed rocks would retain a larger relict fraction of unrecrystallized, hightemperature
quartz grains. Ti content in quartz can therefore be used to map spatial changes in mean exhumation rate. As a rule, Ti concentrations in quartz in the D’Entrecasteaux
Islands increase concentrically inward from 2.5 – 25 ppm at the dome margins to 20 – >100
ppm in…
Advisors/Committee Members: Little, Tim.
Subjects/Keywords: Ultrahigh-pressure; Ti-in-quartz; Rb-Sr dating
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APA (6th Edition):
Korchinski, M. S. (2011). Ascent of Ultrahigh-Pressure Rocks in Southeastern
Papua New Guinea, as Revealed by Ti-in-Quartz
Thermometry and Rb-Sr Dating. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/2023
Chicago Manual of Style (16th Edition):
Korchinski, Megan S. “Ascent of Ultrahigh-Pressure Rocks in Southeastern
Papua New Guinea, as Revealed by Ti-in-Quartz
Thermometry and Rb-Sr Dating.” 2011. Masters Thesis, Victoria University of Wellington. Accessed January 23, 2020.
http://hdl.handle.net/10063/2023.
MLA Handbook (7th Edition):
Korchinski, Megan S. “Ascent of Ultrahigh-Pressure Rocks in Southeastern
Papua New Guinea, as Revealed by Ti-in-Quartz
Thermometry and Rb-Sr Dating.” 2011. Web. 23 Jan 2020.
Vancouver:
Korchinski MS. Ascent of Ultrahigh-Pressure Rocks in Southeastern
Papua New Guinea, as Revealed by Ti-in-Quartz
Thermometry and Rb-Sr Dating. [Internet] [Masters thesis]. Victoria University of Wellington; 2011. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/10063/2023.
Council of Science Editors:
Korchinski MS. Ascent of Ultrahigh-Pressure Rocks in Southeastern
Papua New Guinea, as Revealed by Ti-in-Quartz
Thermometry and Rb-Sr Dating. [Masters Thesis]. Victoria University of Wellington; 2011. Available from: http://hdl.handle.net/10063/2023
Universidad Nacional de La Plata
23.
Escobar, Rodrigo Ignacio.
Geología y génesis de las mineralizaciones barítico-celestínicas asociadas a la secuencia cretácica entre las localidades de Bajada del Agrio y Chos Malal, provincia del Neuquén.
Degree: 2015, Universidad Nacional de La Plata
URL: http://hdl.handle.net/10915/57877
► La Cuenca Neuquina se caracteriza por presentar una compleja historia tectono-estratigráfica relacionada a ciclos de sedimentación carbonáticos, evaporíticos y silicoclásticos, depositados en ambientes marino-continentales durante…
(more)
▼ La Cuenca Neuquina se caracteriza por presentar una compleja historia tectono-estratigráfica relacionada a ciclos de sedimentación carbonáticos, evaporíticos y silicoclásticos, depositados en ambientes marino-continentales durante el lapso Jurásico-Cretácico. En las secuencias carbonático-evaporíticas se hospedan numerosos depósitos barítico-celestínicos de carácter estratoligado. Los depósitos investigados se encuentran vinculados principalmente a calizas estromatolíticas, calizas dolomíticas y niveles evaporíticos del Miembro Troncoso superior y, en menor medida, a calizas dolomíticas del Miembro La Tosca de la Formación Huitrín (Barremiano-Aptiano, Cretácico temprano). En la zona de estudio, estos depósitos se distribuyen a lo largo de una faja de orientación N-S entre las localidades de Bajada del Agrio y Chos Malal. Los distritos más importantes que agrupan a estos depósitos son de norte a sur: Grupo Continental, Cordón del Salado-Cerro Pichi Mula y Bajada del Agrio.
La mineralización básicamente se presenta como: (1) mantos o lentes reemplazando a las facies carbonáticas y yesíferas, estratoligados y concordantes con la estratificación, relacionados a texturas bandeadas o rítmicas; (2) cuerpos abolsonados, que se encuentran rellenando cavidades de disolución y/o fracturas, asociados a texturas de relleno de espacios vacíos (drusas o geodas); (3) cuerpos irregulares, cementando brechas ya sea de colapso kárstico o tectónicas y (4) vetas brechosas asociadas a fracturas de cizalla.
La mineralización mantiforme presenta por un lado un fuerte control litoestratigráfico asociado a facies estromatolíticas y pelíticas y por otro, estructural vinculado a la estructuración de la faja plegada y corrida del Agrio. Las bioconstrucciones microbiales desempeñaron un papel preponderante en la génesis de los depósitos, ya que constituyen niveles de alta porosidad por donde los fluidos mineralizantes han circulado con mayor facilidad hasta ser entrampados, mientras que las facies pelíticas se encuentran por debajo del banco mineralizado, favoreciendo la migración lateral de los fluidos. El fallamiento y plegamiento producto de la tectónica andina, favoreció el transporte y migración de los fluidos a través de la secuencia. Los depósitos están constituidos esencialmente por celestina, la cual presenta composiciones fluctuantes entre (Sr0,948Ba0,002Ca0,05)SO4 y (Sr0,997Ba0,002Ca0,001)SO4. Las determinaciones isotópicas de δ34SCDT para dichos sulfatos varía entre +14 y +33‰, mientras que las determinaciones δ13CPDB y δ18OPDB de los carbonatos asociados a la mineralización fluctúan entre -4,71/-18,68‰ y -6,12/-12,61‰, respectivamente. Se estima que la edad de la mineralización está circunscripta hacia fines del Paleógeno.
Los cuerpos abolsonados se encuentran rellenando cavidades de disolución y están relacionados a la removilización y recristalización del manto original de composicióncelestínica. Los procesos de disolución indican la instauración de un ambiente kárstico, donde posteriormente se depositó una nueva generación de…
Advisors/Committee Members: Barrio, Raúl Ernesto de, Etcheverry, Ricardo O..
Subjects/Keywords: Ciencias Naturales; Geología; Minerales; Cuenca Neuquina; formación Huitrín; mineralizaciones Ba-Sr
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Escobar, R. I. (2015). Geología y génesis de las mineralizaciones barítico-celestínicas asociadas a la secuencia cretácica entre las localidades de Bajada del Agrio y Chos Malal, provincia del Neuquén. (Thesis). Universidad Nacional de La Plata. Retrieved from http://hdl.handle.net/10915/57877
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Escobar, Rodrigo Ignacio. “Geología y génesis de las mineralizaciones barítico-celestínicas asociadas a la secuencia cretácica entre las localidades de Bajada del Agrio y Chos Malal, provincia del Neuquén.” 2015. Thesis, Universidad Nacional de La Plata. Accessed January 23, 2020.
http://hdl.handle.net/10915/57877.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Escobar, Rodrigo Ignacio. “Geología y génesis de las mineralizaciones barítico-celestínicas asociadas a la secuencia cretácica entre las localidades de Bajada del Agrio y Chos Malal, provincia del Neuquén.” 2015. Web. 23 Jan 2020.
Vancouver:
Escobar RI. Geología y génesis de las mineralizaciones barítico-celestínicas asociadas a la secuencia cretácica entre las localidades de Bajada del Agrio y Chos Malal, provincia del Neuquén. [Internet] [Thesis]. Universidad Nacional de La Plata; 2015. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/10915/57877.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Escobar RI. Geología y génesis de las mineralizaciones barítico-celestínicas asociadas a la secuencia cretácica entre las localidades de Bajada del Agrio y Chos Malal, provincia del Neuquén. [Thesis]. Universidad Nacional de La Plata; 2015. Available from: http://hdl.handle.net/10915/57877
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
24.
Μαυρίδου, Σοφία.
Μηχανισμοί μεταγραφικής ρύθμισης του γονιδίου sr-bi του ανθρώπου.
Degree: 2010, University of Crete (UOC); Πανεπιστήμιο Κρήτης
URL: http://hdl.handle.net/10442/hedi/19720
► Scavenger receptor class B type I (SR-BI) facilitates the reverse transport of excess cholesterol from peripheral tissues to the liver via high-density lipoproteins. In steroidogenic…
(more)
▼ Scavenger receptor class B type I (SR-BI) facilitates the reverse transport of excess cholesterol from peripheral tissues to the liver via high-density lipoproteins. In steroidogenic tissues, SR-BI supplies cholesterol for steroid hormone production. In the present thesis, we focused on the role of hormone nuclear receptors in human SR-BI gene regulation in hepatic, adrenal and ovarian cells. We show that the transcription of the human SR-BI gene is subject to feedback inhibition by glucocorticoids in adrenal and ovarian cells. SR-BI mRNA levels were increased in adrenals from corticosterone-insufficient mice, whereas corticosterone replacement by oral administration inhibited SR-BI gene expression in these mice. SR-BI mRNA levels were increased in adrenals from wild-type mice treated with metyrapone, a drug that blocks corticosterone synthesis. Experiments in adrenocortical H295R and ovarian SKOV-3 cells using cycloheximide and siRNA-mediated gene silencing revealed that glucocorticoidmediated inhibition of SR-BI gene transcription requires de novo protein synthesis and the glucocorticoid receptor (GR). No direct binding of GR to the SRBI promoter could be demonstrated in vitro and in vivo, suggesting an indirect mechanism of repression of SR-BI gene transcription by GR in adrenal cells. Deletion analysis established that the region of the human SR-BI promoter between nucleotides -201 and -62 is sufficient to mediate repression by 11 glucocorticoids. This region contains putative binding sites for transcriptional repressors that could play a role in SR-BI gene regulation in response to glucocorticoids. In hepatic cells, SR-BI is regulated by an interplay of multiple hepatocytespecific transcription factors such as Hepatocyte Nuclear Factor 3β (HNF-3β or FOXA2) and the orphan nuclear receptor Hepatocyte Nuclear Factor 4 (HNF-4). Using the human hepatoblastoma HepG2 cells and a model system, we showed that the activity of the hSR-BI promoter is subject to negative regulation by HNF- 4. These data are in agreement with previous studies which had shown that inactivation of the HNF-4 gene in the mouse is associated with a drastic increase in hepatic SR-BI levels. Silencing of the endogenous HNF-4 gene in HepG2 cells by shRNA increased the SR-BI mRNA levels whereas overexpression of HNF-4 repressed endogenous SR-BI gene expression. Promoter deletion analysis established that the region of the human SR-BI promoter between nucleotides - 201 and -62 is sufficient to mediate repression by HNF-4. By in vitro and in vivo protein-DNA interaction assays we demonstrated recruitment of HNF-4 to multiple sites on the hSR-BI promoter, suggesting a direct mechanism of repression of SR-BI gene transcription by HNF-4 in the liver.
Ο υποδοχέας εκκαθαριστής τάξης Β τύπου Ι (SR-BI) διαμεσολαβεί στην αντίστροφη μεταφορά της περίσσειας χοληστερόλης από τους περιφερικούς ιστούς στο ήπαρ μέσω των λιποπρωτεϊνών υψηλής πυκνότητας (HDL). Στους στεροειδογενείς ιστούς ο SR-BI παρέχει χοληστερόλη για την σύνθεση στεροειδών ορμονών. Στην παρούσα…
Subjects/Keywords: Αθηροσκλήρωση; Γλυκοκορτικοειδή; Υποδοχέας HDL; SR - BI; HNF4; Atherosklerosis; Glucocorticoids; HDL receptor
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Μαυρίδου, . . (2010). Μηχανισμοί μεταγραφικής ρύθμισης του γονιδίου sr-bi του ανθρώπου. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/19720
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Μαυρίδου, Σοφία. “Μηχανισμοί μεταγραφικής ρύθμισης του γονιδίου sr-bi του ανθρώπου.” 2010. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed January 23, 2020.
http://hdl.handle.net/10442/hedi/19720.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Μαυρίδου, Σοφία. “Μηχανισμοί μεταγραφικής ρύθμισης του γονιδίου sr-bi του ανθρώπου.” 2010. Web. 23 Jan 2020.
Vancouver:
Μαυρίδου . Μηχανισμοί μεταγραφικής ρύθμισης του γονιδίου sr-bi του ανθρώπου. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2010. [cited 2020 Jan 23].
Available from: http://hdl.handle.net/10442/hedi/19720.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Μαυρίδου . Μηχανισμοί μεταγραφικής ρύθμισης του γονιδίου sr-bi του ανθρώπου. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2010. Available from: http://hdl.handle.net/10442/hedi/19720
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Wright State University
25.
Cheedu, Divya.
Regulation of Mitotic Progression by Btf and TRAP150.
Degree: MS, Biological Sciences, 2016, Wright State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=wright1484576274843721
► Serine-arginine-rich (SR) or SR-like splicing factors interact with exon junction complex proteins during pre-mRNA processing to promote mRNA packaging into mature messenger ribonucleoproteins (mRNPs) and…
(more)
▼ Serine-arginine-rich (
SR) or
SR-like splicing factors
interact with exon junction complex proteins during pre-mRNA
processing to promote mRNA packaging into mature messenger
ribonucleoproteins (mRNPs) and to dictate mRNA stability, nuclear
export, and translation. In this thesis, I examined if depletion of
two homologous non-classical serine-arginine-rich (
SR) splicing
factors, Btf (BCLAF1) and TRAP150, impacts regulation of cell cycle
regulator transcripts and mitosis. Previous work showed that
depletion of these proteins by RNAi causes mitotic defects
including chromosome misalignment in metaphase. However, since Btf
and/or TRAP150 did not co-localize with mitotic structures during
mitosis, I hypothesized that Btf and/or TRAP150 depletion affect
mitosis indirectly through altered expression of mitotic regulator
transcripts. My results indicated that Btf and TRAP150 are
important for controlling the abundance of transcripts that encode
mitotic regulators. My results also suggest that Btf and TRAP150
have increased effects in maintaining the alignment of chromosomes
at metaphase, as co-depletion of Btf and TRAP150 showed increased
effects on the misalignment of chromosomes, thus demonstrating an
important role in mitotic progression. Future studies will
determine if altered expression or processing of endogenous cell
cycle regulator protein transcripts is a result of changes in
transcript distribution, and they will tease apart the molecular
mechanisms underlying defective mitotic chromosome
alignment/segregation in absence of Btf and TRAP150.
Advisors/Committee Members: Bubulya, Paula (Advisor).
Subjects/Keywords: Biology; SR proteins; Btf; TRAP150; Splicing; Mitosis; Cell-cycle regulator transcripts
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MLA ·
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Manager
APA (6th Edition):
Cheedu, D. (2016). Regulation of Mitotic Progression by Btf and TRAP150. (Masters Thesis). Wright State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=wright1484576274843721
Chicago Manual of Style (16th Edition):
Cheedu, Divya. “Regulation of Mitotic Progression by Btf and TRAP150.” 2016. Masters Thesis, Wright State University. Accessed January 23, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1484576274843721.
MLA Handbook (7th Edition):
Cheedu, Divya. “Regulation of Mitotic Progression by Btf and TRAP150.” 2016. Web. 23 Jan 2020.
Vancouver:
Cheedu D. Regulation of Mitotic Progression by Btf and TRAP150. [Internet] [Masters thesis]. Wright State University; 2016. [cited 2020 Jan 23].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1484576274843721.
Council of Science Editors:
Cheedu D. Regulation of Mitotic Progression by Btf and TRAP150. [Masters Thesis]. Wright State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1484576274843721
Portland State University
26.
Satterfield, Laura Elizabeth.
Electrokinetic Properties of Lipid and Sarcoplasmic Reticulum Membranes in Aqueous Electrolyte and in the Presence of Lipophilic Ions.
Degree: PhD, Physics, 2012, Portland State University
URL: https://pdxscholar.library.pdx.edu/open_access_etds/78
► The purpose of this study is the characterization of the membrane-water interfaces of both sarcoplasmic reticulum membrane (SR) and charged lipid bilayers under varied…
(more)
▼ The purpose of this study is the characterization of the membrane-water interfaces of both sarcoplasmic reticulum membrane (
SR) and charged lipid bilayers under varied properties of the surrounding aqueous solution. In this work we studied the electrokinetic properties of liposomes and
SR vesicles as well as the interaction of lipophilic ions with these membranes. The study of electrokinetic properties is based on the measurements of electrophoretic mobility of
SR membrane vesicles and PC/PG liposomes. Electrophoretic mobility of
SR vesicles was measured as a function of ionic strength for six pH values (pH 4.0, 4.7, 5.0, 6.0, 7.5, and 9.0). Electrophoretic mobility of single-layered and multi-layered PC/PG liposomes was measured at neutral pH as a function of ionic strength. For interpretation of electrophoretic mobility studies,
SR vesicles (at pH 4, 7, and 9) and multi-layered and single-layered liposome sizes were determined using photoelectron microscopy. The study of the interaction of lipophilic ions with these membranes is based on (1) measurements of their partition coefficients described in terms of an ion partition model based on the Langmuir adsorption model and (2) electrophoretic mobility measurements of
SR vesicles and PC liposomes in suspension with varied concentration of lipophilic ions.
SR-water and PC-water partition coefficients were measured as a function of concentration for two anions tetraphenylborate (TePB-) and pentabromophenol (PBP-) and two cations (Imipramine+, and Clomipramine+). The anions belong to a class of pesticides and the cations are drugs once prescribed as anti-depressants. Partition into the
SR membrane was shown to be significantly greater for all lipophilic ions except TePB-, which only showed this effect at the higher lipophilic ion range of the data. The PC-water partition coefficient was also measured for TePP+. Since the lipid bilayer of
SR is not significantly different than that of PC liposomes, we believe the differences in partition are due to excess lipophilic ions being absorbed to the proteins of
SR. The electrokinetics of charged PCPG liposomes, and PC liposomes with absorbed lipophilic ions could be understood in terms of the charge being located below their surface and screened by counter-ions inside the polar head-group region. We call this model the "permeable surface model". The assumptions of this model are that (1) the charge exists on a plane at a depth, d, below the surface of the liposome within the lipid head-group region and (2) small ions (Na+, K+, Cl-) are able to penetrate the lipid head-group region with a molar membrane-water partition coefficient of 0.4. Using this model we were able to obtain the depth of sorption of lipophilic ions in PC liposomes. We found values of 0.13 nm for TePB-, 0.5 nm for PBP-, 0.12 nm for Imipramine+, 0.17 nm for Clomipramine and 0.25 nm for TePP+. The depth of lipophilic ions in PC is a valuable quantity for the study of the effect of lipophilic ions on membrane function. For PCPG mobility we found the charged…
Advisors/Committee Members: Pavel Smejtek.
Subjects/Keywords: Biophysics; Sarcoplasmic reticulum; SR vesicles; Electrokinetic properties; Liposomes; Electrophoresis; Fluid Dynamics
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APA (6th Edition):
Satterfield, L. E. (2012). Electrokinetic Properties of Lipid and Sarcoplasmic Reticulum Membranes in Aqueous Electrolyte and in the Presence of Lipophilic Ions. (Doctoral Dissertation). Portland State University. Retrieved from https://pdxscholar.library.pdx.edu/open_access_etds/78
Chicago Manual of Style (16th Edition):
Satterfield, Laura Elizabeth. “Electrokinetic Properties of Lipid and Sarcoplasmic Reticulum Membranes in Aqueous Electrolyte and in the Presence of Lipophilic Ions.” 2012. Doctoral Dissertation, Portland State University. Accessed January 23, 2020.
https://pdxscholar.library.pdx.edu/open_access_etds/78.
MLA Handbook (7th Edition):
Satterfield, Laura Elizabeth. “Electrokinetic Properties of Lipid and Sarcoplasmic Reticulum Membranes in Aqueous Electrolyte and in the Presence of Lipophilic Ions.” 2012. Web. 23 Jan 2020.
Vancouver:
Satterfield LE. Electrokinetic Properties of Lipid and Sarcoplasmic Reticulum Membranes in Aqueous Electrolyte and in the Presence of Lipophilic Ions. [Internet] [Doctoral dissertation]. Portland State University; 2012. [cited 2020 Jan 23].
Available from: https://pdxscholar.library.pdx.edu/open_access_etds/78.
Council of Science Editors:
Satterfield LE. Electrokinetic Properties of Lipid and Sarcoplasmic Reticulum Membranes in Aqueous Electrolyte and in the Presence of Lipophilic Ions. [Doctoral Dissertation]. Portland State University; 2012. Available from: https://pdxscholar.library.pdx.edu/open_access_etds/78
Wright State University
27.
Varia, Sapna N.
Elucidating a Role of Btf and TRAP150 in pre-mRNA Processing
and Cell Cycle Progression.
Degree: PhD, Biomedical Sciences PhD, 2013, Wright State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=wright1369831297
► Transcription of protein-coding genes is coordinated with pre-mRNA processing as well as mRNP assembly and nuclear export in mammalian cells. In this dissertation, I examined…
(more)
▼ Transcription of protein-coding genes is coordinated
with pre-mRNA processing as well as mRNP assembly and nuclear
export in mammalian cells. In this dissertation, I examined the
functions of two homologous non-classical serine-arginine-rich (
SR)
proteins, Btf (BCLAF1) and TRAP150 in these steps of gene
regulation. Since Btf and TRAP150 share 39% sequence identity and
66% sequence similarity, I also examined whether Btf and TRAP150
have overlapping or distinct functions in pre-mRNA processing.
Using two different reporter loci, I showed in-situ recruitment of
Btf and TRAP150 at reporter transcription sites, and I identified
both Btf and TRAP150 being associated with a core EJC component
Magoh. However, my data indicate that these proteins have different
roles in maintaining the cellular mRNA distribution in HeLa cells.
My data demonstrate that Btf depletion, but not compensatory
TRAP150 up-regulation, leads to a global change in cellular
distribution of mRNA. Thus, my data reveal that modulating the
expression of a single protein, Btf, has global impact upon the
nuclear/cytoplasmic distribution of mRNAs. In addition, HeLa cells
depleted of Btf and TRAP150 showed chromosomal misalignment at
metaphase. This suggests that both proteins regulate the mitotic
progression of HeLa cells. My exon microarray data show cell cycle
and mitosis as the major processes being affected in Btf or TRAP150
depleted HeLa cells. In all, my results suggest that both Btf and
TRAP150 have distinct but important roles in maintaining mRNA
distribution in cells, but they are both important for mitotic
progression. Future studies will determine if absence of Btf or
TRAP150 leads to altered processing of endogenous transcripts
encoding cell cycle regulator proteins, thereby affecting the
cellular distribution of these mRNAs and providing a mechanism for
mitotic regulation by Btf and TRAP150.
Advisors/Committee Members: Mamrack, Mark (Committee Chair), Bubulya, Paula (Advisor).
Subjects/Keywords: Molecular Biology; Biology; Genetics; SR proteins; Btf; TRAP150; EJC; splicing
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APA (6th Edition):
Varia, S. N. (2013). Elucidating a Role of Btf and TRAP150 in pre-mRNA Processing
and Cell Cycle Progression. (Doctoral Dissertation). Wright State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=wright1369831297
Chicago Manual of Style (16th Edition):
Varia, Sapna N. “Elucidating a Role of Btf and TRAP150 in pre-mRNA Processing
and Cell Cycle Progression.” 2013. Doctoral Dissertation, Wright State University. Accessed January 23, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1369831297.
MLA Handbook (7th Edition):
Varia, Sapna N. “Elucidating a Role of Btf and TRAP150 in pre-mRNA Processing
and Cell Cycle Progression.” 2013. Web. 23 Jan 2020.
Vancouver:
Varia SN. Elucidating a Role of Btf and TRAP150 in pre-mRNA Processing
and Cell Cycle Progression. [Internet] [Doctoral dissertation]. Wright State University; 2013. [cited 2020 Jan 23].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1369831297.
Council of Science Editors:
Varia SN. Elucidating a Role of Btf and TRAP150 in pre-mRNA Processing
and Cell Cycle Progression. [Doctoral Dissertation]. Wright State University; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1369831297
NSYSU
28.
Guo, Cing-Shun.
Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas.
Degree: Master, Marine Biotechnology and Resources, 2014, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420
► Lenticular mafic volcanic rocks, intercalated with Tertiary sedimentary rocks in the Western foothills of Taiwan, have been altered, and transformed into chloritic clay minerals such…
(more)
▼ Lenticular mafic volcanic rocks, intercalated with Tertiary sedimentary rocks in the Western foothills of Taiwan, have been altered, and transformed into chloritic clay minerals such as chlorite, corrensite and smectite. This study, based on the petrography and mineral chemical analysis ,use the trace elements, rare earth elements and isotopes of the volcanic rocks from Neimen and Fangshan areas to investigate the (1) the information of magmatic source and tectonic. (2) relationship of trace elements, rare earth elements and isotope following the degree of alteration between the samples. (3) elements exchange of fluid-rock interaction. (4) distribution of trace elements between the primary and secondary clay minerals. Volcanic rocks of Neimen occur in the sandstone-shale interlayer of Nanchuang formation. In contrast, volcanic rocks in Fangshan River occur as rolling stone. Neimen basalts belong to alkaline basalts, with porphyritic texture. Phenocrysts compose of pyroxene and olivine. Due to alteration processes, olivine phenocrysts are partially replaced by secondary clay minerals which can be subdivided into vein center (VC), vein (V), mica-like(MA) fibrous(F) texture. Augite phenocrysts have not affected by significant alteration. The matrix contains augite, plagioclase, alkali feldspar, titanium magnetite, ilmenite, apatite and clay minerals such as chlorite and smectite, which replace from the matrix. The samples from Fangshan occur as amygdaloidal texture, and are characterized by spilitization features which indicate higher degree of alteration. Its primary minerals have been replaced, remaining the original texture, so it is difficult to identify the type of primary minerals. Amygdules compose of chlorite, calcite, dolomite and quartz. The matrix contains albite, chlorite, corrensite, rutile, apatite, with trace minerals such as chromite, pyrite, chalcopyrite, sphalerite, monazite, halite, and florencite ((Ce, La,
Sr)Al3(PO4)2(OH)6). The loss on ignition(L.O.I.) for Neimen and Fangshan samples are 3.20 ~ 4.22 and 4.71 ~ 11.52. Excluding the elements affected by the alteration such as Li, Cs, Rb,
Sr and Ti, the trace elements and REE trends in Neimen and Fangshan is closed to ocean island basalt (OIB). According to Zr-Ti-Y and Ha-Th-Ta diagram, the erupted environments of Neimen and Fangshan are intraplate basalts.
Sr-Nd isotope system of Neimen is close to fresh samples, but the 87Sr/86Sr of Fangshan is deviated from mantle evolution trend (mantle array) suggesting the reaction fluid may be sea water and have been contaminated by crust endmember when the Igneous stage. LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry) trace element analysis suggests that: both the LREE and incompatible elements of clinopyroxene are depleted. Excluding Ni and Co, olivine doesnât enrich incompatible trace elements. The trends of matrix and whole rock are similar. Li and Cs in clay minerals are apparently enriched. The mica-like clay (MA) has very low trace elements abundance, similar to olivine,…
Advisors/Committee Members: Yen-Hong Shau (committee member), Wei-Teh Jiang (chair), Huai-Jen Yang (chair).
Subjects/Keywords: trace elements; Sr-Nd isotopic; hydrothermal alteration; smectite; corrensite; spilite; chlorite
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APA ·
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APA (6th Edition):
Guo, C. (2014). Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Guo, Cing-Shun. “Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas.” 2014. Thesis, NSYSU. Accessed January 23, 2020.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Guo, Cing-Shun. “Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas.” 2014. Web. 23 Jan 2020.
Vancouver:
Guo C. Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas. [Internet] [Thesis]. NSYSU; 2014. [cited 2020 Jan 23].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Guo C. Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
29.
Huang, Jung-heng.
Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals.
Degree: Master, Materials Science and Engineering, 2006, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714
► In this work, two (La,Sr)(Al,Ta) O3 single crystals were grown by the conventional Czochralski pulling method by using different rotation rates and pull rates to…
(more)
▼ In this work, two (La,
Sr)(Al,Ta) O3 single crystals were grown by the conventional Czochralski pulling method by using different rotation rates and pull rates to find out the optimal growth conditions. The total length of the first (La,
Sr)(Al,Ta) O3 crystal is about 8.5cm, and the shape is not symmetrical. The small thermal conductivity of the crystal would lead to small temperature gradient, so the growth rate was slow. The shape of the second crystal was improved by adjusting the thermal field. But, the bottom of the residual has blue color. The blue residual was analysed by x-ray and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Besides, the crystal structure was analyzed and the second phase had been found in crystals by high angle x-ray spectrum and polarizer microscope.
Advisors/Committee Members: none (chair), none (chair), Mitch Chou (committee member).
Subjects/Keywords: Sr)(Al; (La; Ta)O3
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APA ·
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APA (6th Edition):
Huang, J. (2006). Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Huang, Jung-heng. “Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals.” 2006. Thesis, NSYSU. Accessed January 23, 2020.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Huang, Jung-heng. “Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals.” 2006. Web. 23 Jan 2020.
Vancouver:
Huang J. Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals. [Internet] [Thesis]. NSYSU; 2006. [cited 2020 Jan 23].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Huang J. Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals. [Thesis]. NSYSU; 2006. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
野坂, 隆.
アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナ セラミックス キバンジョウ ニ サクセイシタ マイクロハ カヘン ヨウリョウ (Ba, Sr)TiO3 ハクマク ノ コウシンライセイカ ニ カンスル ケンキュウ.
Degree: Nara Institute of Science and Technology / 奈良先端科学技術大学院大学
URL: http://hdl.handle.net/10061/5233
Subjects/Keywords: (Ba; Sr)TiO3薄膜
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APA ·
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APA (6th Edition):
野坂, . (n.d.). アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナ セラミックス キバンジョウ ニ サクセイシタ マイクロハ カヘン ヨウリョウ (Ba, Sr)TiO3 ハクマク ノ コウシンライセイカ ニ カンスル ケンキュウ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/5233
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
野坂, 隆. “アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナ セラミックス キバンジョウ ニ サクセイシタ マイクロハ カヘン ヨウリョウ (Ba, Sr)TiO3 ハクマク ノ コウシンライセイカ ニ カンスル ケンキュウ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed January 23, 2020.
http://hdl.handle.net/10061/5233.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
野坂, 隆. “アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナ セラミックス キバンジョウ ニ サクセイシタ マイクロハ カヘン ヨウリョウ (Ba, Sr)TiO3 ハクマク ノ コウシンライセイカ ニ カンスル ケンキュウ.” Web. 23 Jan 2020.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
野坂 . アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナ セラミックス キバンジョウ ニ サクセイシタ マイクロハ カヘン ヨウリョウ (Ba, Sr)TiO3 ハクマク ノ コウシンライセイカ ニ カンスル ケンキュウ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2020 Jan 23].
Available from: http://hdl.handle.net/10061/5233.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
野坂 . アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナ セラミックス キバンジョウ ニ サクセイシタ マイクロハ カヘン ヨウリョウ (Ba, Sr)TiO3 ハクマク ノ コウシンライセイカ ニ カンスル ケンキュウ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/5233
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
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Open Access Theses and Dissertations
