subject:(Sr)

1. Elisandra Do Nascimento, Graziele. Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais .

Degree: 2011, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/6173

► A corrosão por ácidos naftênicos a altas temperaturas nas unidades de refino é um dos maiores problemas nas refinarias de todo o mundo, uma vez… (more)

▼ A corrosão por ácidos naftênicos a altas temperaturas nas unidades de refino é um dos maiores problemas nas refinarias de todo o mundo, uma vez que, podem causar envenenamento de catalisadores e paradas operacionais de alto custo. Os ácidos naftênicos correspondem a uma mistura complexa de ácidos carboxílicos presentes no petróleo, responsáveis diretamente pela sua acidez e corrosividade. Tais compostos também estão presentes nas frações destiladas do petróleo, causando diversos problemas na qualidade final do produto. Dentre estas frações do petróleo pode-se destacar o querosene de aviação (QAV) que é produzido através do fracionamento por destilação à pressão atmosférica. Os óleos nacionais estão cada vez mais ácidos, estimulando a busca por novos e eficientes métodos de mitigação. Métodos propostos por estudos científicos e industriais para minimizar a corrosão provocada por ácidos naftênicos vêm apresentando custos elevados e problemas de operação. O processo de adsorção tem a vantagem da possibilidade de recuperação dos ácidos orgânicos, que são precursores de surfactantes e aditivos para lubrificantes, não havendo formação de resíduos poluentes e contribuindo com o meio ambiente. As peneiras moleculares mesoporosas (MCM-41) vêm despertando grande interesse na comunidade científica em função da perspectiva da sua aplicação em processos de adsorção e catálise. A fim de reduzir o alto custo dos processos de separação por adsorção, principalmente devido ao elevado valor de alguns adsorventes, a utilização de resíduos agroindustriais como adsorventes vem se destacando como método alternativo. O objetivo deste trabalho foi a remoção da acidez naftênica de uma mistura modelo de QAV (ácido dodecanóico em ndodecano) com uso do adsorvente Sr-MCM-41 e de adsorvente preparado a partir de resíduo agroindustrial. No presente trabalho foi sintetizada a peneira molecular mesoporosa Sr-MCM- 41, na qual a incorporação do estrôncio resultou no aumento da basicidade do material e consequentemente da sua afinidade pelos ácidos. O adsorvente Sr-MCM-41 foi caracterizado por análise termogravimétrica (TG) e termogravimétrica diferencial (DTG), difração de raios- X (DRX), medida de área superficial por adsorção de N2 (BET), espectrometria de emissão óptica com plasma indutivamente acoplado (ICP-OES) e espectroscopia na região do infravermelho com transformada de Fourier (FT-IR). Os resultados da caracterização deste material indicaram que a incorporação do estrôncio não comprometeu a estrutura mesoporosa e que os materiais sintetizados apresentaram um bom grau de organização. Foi utilizada a técnica de planejamento fatorial para otimização do processo adsortivo visando a determinação das melhores condições de operação. Em seguida foram realizados estudos de cinética e equilíbrio de adsorção com o adsorvente Sr-MCM-41, obtendo-se como capacidade máxima adsortiva 2,0 gácido.g-1 adsorvente, a partir do estudo de equilíbrio de adsorção. Os dados de equilíbrio foram ajustados a isoterma de BET tipo IV. A… Advisors/Committee Members: Maria Bezerra De Menezes, Celmy (advisor).

Subjects/Keywords: Sr-MCM-41; Adsorção; QAV

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APA (6^th Edition):

Elisandra Do Nascimento, G. (2011). Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/6173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elisandra Do Nascimento, Graziele. “Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais .” 2011. Thesis, Universidade Federal de Pernambuco. Accessed January 23, 2021. http://repositorio.ufpe.br/handle/123456789/6173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elisandra Do Nascimento, Graziele. “Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais .” 2011. Web. 23 Jan 2021.

Vancouver:

Elisandra Do Nascimento G. Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2011. [cited 2021 Jan 23]. Available from: http://repositorio.ufpe.br/handle/123456789/6173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elisandra Do Nascimento G. Remoção de ácidos naftênicos em mistura modelo de querosene de aviação (Ácido n-dodecanóico em n-dodecano) por adsorção, utilizando novos materiais . [Thesis]. Universidade Federal de Pernambuco; 2011. Available from: http://repositorio.ufpe.br/handle/123456789/6173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

2. Aljarallah, Aishah. INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI.

Degree: PhD, 2011, McMaster University

URL: http://hdl.handle.net/11375/11437

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High density lipoprotein (HDL) is an independent risk factor for thedevelopment of coronary heart disease. HDL mediated reverse cholesterol transport is a key element… (more)

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High density lipoprotein (HDL) is an independent risk factor for thedevelopment of coronary heart disease. HDL mediated reverse cholesterol transport is a key element responsible for the cardioprotective effects of HDL. In addition HDL exerts other atheroprotective effects in vascular cells. The HDL receptor, scavenger receptor class I type B (SR-BI) derives the process of reverse cholesterol transport, mediates HDL signaling in the vasculature and protects against atherosclerosis. However, the exact atheroprotective mechanisms of HDL and SR-BI are not clearly understood.This thesis starts by characterizing a model of occlusive coronary arteryatherosclerosis, the SR-BI/apolipoprotein E double knockout mice and tests the effectsof phenolic rich pomegranate extract on disease progression. Coronary artery disease in these mice starts at three weeks of age and progresses rapidly leading to sudden death within three to five weeks. The administration of pomegranate extract reduced the extent of coronary artery atherosclerosis possibly via mechanisms that involved alterations in lipid metabolism and reduced inflammation and oxidative stress.The next two chapters aimed to gain better understanding of the atheroprotectiveactions of HDL and SR-BI. Increased macrophage apoptosis is a key event in the development of atherosclerotic plaques. HDL signaling via SR-BI reduced macrophage apoptosis while the lack of macrophage SR-BI was associated with increased macrophage apoptosis and necrotic core areas, features of plaque instability. Next HDL and SR-BI effects on macrophage migration, a key event in atherosclerotic plaque regression, are described. HDL stimulated the migration of macrophages in a manner that was dependent on SR-BI, its adaptor protein, PDZK1, and the G-protein coupled receptor, sphingosine-1-phosphate receptor 1. SR-BI mediated macrophage migration may suggest a potential role of SR-BI in atherosclerotic plaque regression.To expand our view of HDL effects on macrophages we have used proteomics as an approach. HDL treatment of macrophages altered the expression of multiple proteins.Validation experiment confirmed changes in interesting and particularly relevant protein targets in HDL mediated protection against macrophage apoptosis and inflammation and in HDL induced macrophage migration. Follow up experiments will determine their involvement in HDL and SR-BI mediated signaling. Overall this work represents a milestone in understanding the atheroprotective effects of HDL and SR-BI in macrophages.

Doctor of Philosophy (PhD)

Advisors/Committee Members: Trigatti, Bernardo, Geoff Werstuck and Joseph Macri, Geoff Werstuck and Joseph Macri, Biochemistry.

Subjects/Keywords: HDL; SR-BI; Macrophages; Signaling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aljarallah, A. (2011). INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/11437

Chicago Manual of Style (16^th Edition):

Aljarallah, Aishah. “INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI.” 2011. Doctoral Dissertation, McMaster University. Accessed January 23, 2021. http://hdl.handle.net/11375/11437.

MLA Handbook (7^th Edition):

Aljarallah, Aishah. “INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI.” 2011. Web. 23 Jan 2021.

Vancouver:

Aljarallah A. INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI. [Internet] [Doctoral dissertation]. McMaster University; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11375/11437.

Council of Science Editors:

Aljarallah A. INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI. [Doctoral Dissertation]. McMaster University; 2011. Available from: http://hdl.handle.net/11375/11437

University of Waterloo

3. Hall, Karlee. Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle.

Degree: 2011, University of Waterloo

URL: http://hdl.handle.net/10012/6144

► The purpose of this study was to investigate whether skeletal muscle sarcoplasmic reticulum (SR) Ca2+ transport efficiency and expression levels of major SR Ca2+ regulatory… (more)

▼ The purpose of this study was to investigate whether skeletal muscle sarcoplasmic reticulum (SR) Ca2+ transport efficiency and expression levels of major SR Ca2+ regulatory proteins are associated with resting metabolic rate (RMR) in humans. Twenty five healthy and weight stable participants with mean age, height and weight of 22±3.6 years, 174.6±8.0 cm and 72.8±21 kg respectively, were recruited for the study. RMR was calculated using the Weir equation based upon measures of VO2 and VCO2, which were collected using the Vmax breath by breath indirect calorimetry system. Ca2+-ATPase activity, Ca2+ uptake and Ca2+ leak analyses were performed in vitro on homogenates that were prepared from vastus lateralis muscle biopsies. Ionophore (IONO) ratio was assessed by measuring Ca2+-ATPase activity in the presence and absence of Ca2+ Ionophore. The coupling ratio, a measure of SR Ca2+ transport efficiency, was calculated by taking the ratio of Ca2+ uptake to Ca2+-ATPase activity. Expression levels of the major SR Ca2+ regulatory proteins, including SERCA1a, SERCA2a, phospholamban (PLN), and calsequestrin (CSQ) were assessed using Western blotting techniques. Pearson correlation coefficient analysis demonstrated a weak but significant negative correlation between coupling ratio and RMR (r2= 0.2108, p =0.0240). Content of the SR Ca2+ regulatory proteins, IONO ratio and Ca2+ leak were not found to be significantly related to either RMR or coupling ratio, with the exception of the ratio of SERCA1a to SERCA2a, which showed a weak but significant positive relationship with RMR (r2=0.1781, p=0.0400). Thus, the relationship between coupling ratio and RMR is not influenced by Ca2+ leak, SERCA pump efficiency or the SR Ca2+ regulatory proteins. Overall, these results suggest that the efficiency of SR Ca2+ transport is weakly related to whole body RMR. Further analysis is needed to assess this relationship, and to determine which SR Ca2+ handling properties are influencing the relationship between coupling ratio and RMR.

Subjects/Keywords: RMR; SR Ca2+ transport efficiency

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hall, K. (2011). Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/6144

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hall, Karlee. “Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle.” 2011. Thesis, University of Waterloo. Accessed January 23, 2021. http://hdl.handle.net/10012/6144.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hall, Karlee. “Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle.” 2011. Web. 23 Jan 2021.

Vancouver:

Hall K. Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle. [Internet] [Thesis]. University of Waterloo; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10012/6144.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hall K. Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle. [Thesis]. University of Waterloo; 2011. Available from: http://hdl.handle.net/10012/6144

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Santos, Priscila Ribeiro dos. A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio.

Degree: Mestrado, Física, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;

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Esta dissertação de mestrado descreve o estudo realizado sobre como a oferta de estrôncio afeta a razão Sr/Ca em hidroxiapatita formada in vitro. Este trabalho… (more)

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Esta dissertação de mestrado descreve o estudo realizado sobre como a oferta de estrôncio afeta a razão Sr/Ca em hidroxiapatita formada in vitro. Este trabalho pretende dar subsídios para que posteriormente seja possível fazer um estudo da razão Sr/Ca em função da temperatura também em hidroxiapatita formada in vitro. Foram utilizadas células osteoblásticas da linhagem MG-63 com concentrações de estrôncio no meio de cultura que variaram de 0,0 até 33,0 microgramas por mL de meio. Os nódulos ósseos formados pelas células foram caracterizados pelas técnicas Absorção de Infravermelho por Transformada de Fourier (FT-IR), que foi utilizada com o objetivo de identificar ligações de fosfato nas amostras, e Difração de Raios-X (XRD), que teve como objetivo confirmar a presença de hidroxiapatita nos minerais formados e comparar a cristalinidade do material com e sem estrôncio. A quantificação da razão Sr/Ca foi feita utilizando as técnicas Retro-espalhamento Rutherford (RBS) e Emissão de Raios-X por Indução de Partículas (PIXE), que são capazes de fazer a identificação e quantificação elementar. Os resultados obtidos mostram que os nódulos formados são compostos por hidroxiapatita. Com relação à quantificação, mostrou-se que não foi possível substituir mais de 10% do íons de cálcio por íons de estrôncio, o que está de acordo com previsões teóricas. Além disso, para altas concentrações de estrôncio no meio a mineralização do cálcio diminuiu duas ordens de grandeza e as medidas da razão Sr/Ca obtiveram resultados bastante dispersos, indicando uma possível mudança metabólica das células que parece inviabilizar o bom funcionamento fisiológico das mesmas.

This Masters dissertation describes the study of how the availability of strontium affects Sr/Ca ratio of in vitro hydroxyapatite. This work intends to provide the basic understanding needed to a future study of how temperature changes Sr/Ca ratio in this material. MG-63 cells were grown in the culture medium doped with 0.0, 1.0, 2.0, 4.1, 8.2, 16.4, 22.9 and 33.0 micrograms of Sr/mL. The nodules formed by osteoblastic cells were characterized by Fourier Transform Infrared Spectroscopy (FT-IR) technique, used to identify phosphate domain, and X-Ray Diffraction (XRD) technique, which was used to verify the presence of crystallized hydroxyapatite in the mineral composition with and without strontium. Quantification of Sr/Ca ratio was made using the Rutherford Backscattering (RBS) and Particle Induced X-Ray Emission (PIXE) techniques, which are used to do elementary identification and quantification. The results of characterization confirmed the presence of hydroxyapatite in the cultivated MG-63 cells. The experiments have shown that it was not possible to replace more than 10% of the calcium ions by strontium, which is consistent with theoretical predictions. In addition, high concentrations of strontium in the growing solution, reduced the mineralization yield and also the Sr/Ca ratio, indicating a possible change in the metabolism of the cells.

Advisors/Committee Members: Added, Nemitala.

Subjects/Keywords: hidroxiapatita; hydroxyapatite; PIXE; PIXE; Sr/Ca; Sr/Ca; XRD; XRD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, P. R. d. (2008). A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;

Chicago Manual of Style (16^th Edition):

Santos, Priscila Ribeiro dos. “A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio.” 2008. Masters Thesis, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;.

MLA Handbook (7^th Edition):

Santos, Priscila Ribeiro dos. “A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio.” 2008. Web. 23 Jan 2021.

Vancouver:

Santos PRd. A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;.

Council of Science Editors:

Santos PRd. A razão Sr/Ca em hidroxiapatita produzida a partir de células ósseas humanas em ambientes com diferentes concentrações de estrôncio. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/43/43134/tde-02032009-163100/ ;

University of Vienna

5. Maronova, Monika. Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens.

Degree: 2017, University of Vienna

URL: http://othes.univie.ac.at/48522/

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Alternatives Spleißen (AS) ist ein hochregulierter Prozess, der mehrere mRNAVarianten aus einem einzigen Gen erzeugt und zur Transkriptom- und Proteom-Diversität und Feinabstimmung der Genexpression in… (more)

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Alternatives Spleißen (AS) ist ein hochregulierter Prozess, der mehrere mRNAVarianten aus einem einzigen Gen erzeugt und zur Transkriptom- und Proteom-Diversität und Feinabstimmung der Genexpression in höheren Eukaryoten wesentlich beiträgt. Einer der Hauptakteure in AS sind SR-Proteine, eine Familie von evolutionär konservierten Spleißfaktoren. Arabidopsis-Genom kodiert achtzehn SR-Proteine und ihre Regulierung und exakte Funktionen sind unklar. Um eine komplexe Regulierung von AS zu sezieren, ist es von großer Wichtigkeit, die Veränderungen in AS unter bestimmten Bedingungen präzise zu überwachen, aber solche Methoden sind in Pflanzen nicht gut etabliert. Die vorliegende Arbeit beschreibt die Entwicklung und Anwendung eines neuartigen hochauflösenden (HR) RT-PCR-Screens, um Veränderungen in mehreren bekannten AS-Ereignissen unter den gewünschten Bedingungen und genetischen Hintergründen zu messen. Das System erwies sich als reproduzierbar, präzise und auch in der Lage, neuartige AS-Transkripte zu erkennen. Während meiner Dissertation konzentrierte ich mich auf ein pflanzenspezifisches SRProtein At-RS31. HR-RT-PCR-Screen-Analyse der At-RS31-Überexpression (ÜE) Linie zeigte an, dass At-RS31 AS von Genen, die beteiligen sich am RNA-Metabolismus und Spleißen, Transkription und DNA-Reparatur, moduliert. Interessanterweise beeinflusste ÜE von At-RS31 das Spleißmuster des DNA-Reparaturgens UVH1/ATRAD1 und ähnlich wie bei uvh1 Mutanten waren At-RS31- ÜE -Pflanzen gegenüber der UV-C-Exposition überempfindlich. Erhöhte Levels von At-RS31 verschärfte Effekte von mehreren anderen abiotischen Belastungen und förderten eine frühe Seneszenz, was auf eine wichtige Rolle und eine enge Regulierung der At-RS31-Expression für das Überleben der Pflanzen in wechselnder Umgebung hindeutet. Die Kenntnis der in Arabidopsis gewonnenen Pflanzen-SR-Gene wurde durch das Studium des Moos Physcomitrella patens ergänzt. Obwohl evolutionärer entfernter Organismus, besitzt Physcomitrella SR-Gene mit hoch konservierter Struktur und AS zu Arabidopsis. Die Charakterisierung von AS in drei orthologen SR-Genen enthüllte ein extensives Spleißen im langen Intron von Pp-RS27 und mehrfache Spleißvarianten von zwei Genen der Pp-RS2Z-Subfamilie. Bemerkenswerterweise zeigte die Analyse von ASVarianten unter verschiedenen Wachstumsbedingungen, dass AS von Pp-RS27 Veränderungen in Reaktion auf UV-C und Licht gegenüber Dunkel zeigt, ähnlich die Beobachtungen in seinem Orthologe At-RS31, was auf einen hoch konservierten Mechanismus zur Regulierung von AS in Antwort auf externe Anregungen.

Alternative splicing (AS) is a highly regulated process that generates multiple mRNA variants from a single gene and contributes greatly to the transcriptome and proteome diversity and fine tuning of gene expression in higher eukaryotes. One of the key players in AS are SR proteins, a family of evolutionary conserved splicing factors. Arabidopsis genome encodes eighteen SR proteins and their regulation and exact functions are unclear. To dissect complex regulation of AS it…

Subjects/Keywords: 42.13 Molekularbiologie; Alternatives Spleissen / SR Proteine; alternative splicing / SR proteins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maronova, M. (2017). Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/48522/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maronova, Monika. “Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens.” 2017. Thesis, University of Vienna. Accessed January 23, 2021. http://othes.univie.ac.at/48522/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maronova, Monika. “Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens.” 2017. Web. 23 Jan 2021.

Vancouver:

Maronova M. Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens. [Internet] [Thesis]. University of Vienna; 2017. [cited 2021 Jan 23]. Available from: http://othes.univie.ac.at/48522/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maronova M. Comparative study of plant SR genes regulation and function in Arabidopsis thaliana and Physcomitrella patens. [Thesis]. University of Vienna; 2017. Available from: http://othes.univie.ac.at/48522/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Vitolo, Giancarlo. Valoración AES Panamá SRL.

Degree: 2018, Universidad de Chile

URL: http://repositorio.uchile.cl/handle/2250/165794

► El trabajo desarrollado a continuación, tiene como principal objetivo efectuar la valoración de la empresa AES Panamá SRL y estimar el precio de su acción,… (more)

▼ El trabajo desarrollado a continuación, tiene como principal objetivo efectuar la valoración de la empresa AES Panamá SRL y estimar el precio de su acción, a través de la metodología de flujos de caja descontados (FCD). Esta metodología se basa en el modelo multiperiodo de Modigliani-Miller, que consiste principalmente en modelar los flujos de caja libre de la compañía sobre un horizonte de tiempo determinado, para luego ser descontados a su valor presente. Además de estos flujos de caja, el valor presente debe ser determinado para flujos de caja más allá del horizonte de proyección comúnmente llamado valor terminal o perpetuidad. Bajo esta metodología determinar la tasa de descuento es uno de los factores fundamentales. Para esto se deben considerar aspectos claves como el riesgo, comportamientos históricos y el rendimiento mínimo esperado por compradores o vendedores con una expectativa mínima de rentabilidad. En esta valoración utilizamos una tasa de costo de capital, calculada a través de la fórmula WACC, la cual consiste en un promedio ponderado entre el costo de la deuda (kb) y la rentabilidad exigida por los accionistas (kp). Para realizar la valoración a través de esta metodología, es necesario determinar una estructura de capital objetivo a largo plazo para la compañía, la cual puede obtenerse en base al análisis retrospectivo de las cifras presentadas en sus estados financieros. Como parte de la valoración completa de la empresa bajo este método, debemos identificar y adicionar sus activos prescindibles (activos no necesarios para la operación de la empresa) y ajustar el exceso o déficit de capital de trabajo que haya al momento de la valoración. Como último paso en esta valoración, se determina el valor económico del patrimonio restando al valor obtenido de la empresa el valor presente de la deuda financiera al momento de la valoración. Adicionalmente a la valoración a través del método de FCD, estimaremos el valor de la empresa AES Panamá SRL y el precio de su acción por el método de múltiplos. Este método consiste básicamente en estimar el valor de una empresa analizando la relación de las razones financieras de compañías que pertenecen a la misma industria tomadas como benchmark. AES Panamá, es una empresa que genera y vende electricidad en el mercado panameño y mercado eléctrico regional (MER), es la mayor compañía de generación en Panamá en términos de capacidad instalada y energía despachada promedio, donde el 93% de la capacidad firme de las plantas de la Compañía se encuentra contratada bajo varios acuerdos de compra - venta de potencia y energía con compañías de distribución, grandes clientes y la compañía generadora AES Changuinola. La energía excedente es vendida en el mercado ocasional a los precios establecidos en el mismo (precio spot) Para la ejecución de esta valoración se usaron los estados financieros de la empresa y de compañías que componen la industria desde el 30 de junio de 2013 hasta el 30 de septiembre de 2017, por otra parte, se extrajeron los…

Subjects/Keywords: Valoración; Valoración de empresas; AES Panamá SR

10 more images…

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APA (6^th Edition):

Vitolo, G. (2018). Valoración AES Panamá SRL. (Thesis). Universidad de Chile. Retrieved from http://repositorio.uchile.cl/handle/2250/165794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vitolo, Giancarlo. “Valoración AES Panamá SRL.” 2018. Thesis, Universidad de Chile. Accessed January 23, 2021. http://repositorio.uchile.cl/handle/2250/165794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vitolo, Giancarlo. “Valoración AES Panamá SRL.” 2018. Web. 23 Jan 2021.

Vancouver:

Vitolo G. Valoración AES Panamá SRL. [Internet] [Thesis]. Universidad de Chile; 2018. [cited 2021 Jan 23]. Available from: http://repositorio.uchile.cl/handle/2250/165794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vitolo G. Valoración AES Panamá SRL. [Thesis]. Universidad de Chile; 2018. Available from: http://repositorio.uchile.cl/handle/2250/165794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Macquarie University

7. Herath, Herath Mudiyanselage Dilmi Vindya. Bivalve shells as paleo-proxy archives: assessment of the usefulness as environmental and climatic recorders in the Southern Hemisphere.

Degree: 2018, Macquarie University

URL: http://hdl.handle.net/1959.14/1274033

►

Theoretical thesis.

Thesis by publication.

Introduction – 1. The freshwater bivalve Echyridella menziesii: a new environmental archive from Lake Rotorua, New Zealand – 2. Temperature… (more)

▼

Theoretical thesis.

Thesis by publication.

Introduction – 1. The freshwater bivalve Echyridella menziesii: a new environmental archive from Lake Rotorua, New Zealand – 2. Temperature reconstructions by δ¹⁸O and Sr/Ca using freshwater bivalve Echyridella menziesii from New Zealand – 3. The potential of three east Australian freshwater bivalve species as environmental proxy archives – 4. Climate signals in the shells of Diplodon chilensis patagonicus (Haas, 1931) bivalves in northern Patagonia, Argentina – 5. Medieval climatic anomaly signals in fossil Diplodon chilensis patagonicus (Haas, 1931) shells from northern Patagonia – Conclusions.

In contrast to other skeletal bio-carbonates, the potential of freshwater bivalves as environmental and climate archives has been less explored, despite the fact that freshwater bivalves are well-known to record environmental variables such as temperature, precipitation, primary productivity, and river discharge in multiple ways which facilitates the combination of numerous proxies that strengthens the proxy records. Although there are a large number of marine proxy studies in the southern hemisphere, the number of similar studies in freshwater environments are comparatively limited, creating a considerable lack of understanding on the past continental climate in the region. In this thesis, freshwater bivalves are studied from three different localities at similar latitudes in the southern hemisphere, namely New Zealand, Australia and South America, in order to identify the potential of five different species as new environmental proxy archives. The results show that physical and chemical characteristics in three studied species; Echyridella menziesii , Alathyria profuga and Diplodon chilensis patagonicus have the possibility to be used as proxies of numerous environmental and climatic variables. Echyridella menziesii and Alathyria profuga exhibit the suitability of using shell oxygen isotope ratio as a temperature proxy since temperature reconstructions using these proxies agree well (± 2.5 and ± 3.5 °C respectively) with instrumental temperature data. Similarly, Sr/Ca in Echyridella menziesii and Diplodon chilensis patagonicus can function as a proxy of ambient temperature as both exhibit significant correlations (r > 0.6, p < 0.05) with instrumental temperature. More importantly, this study introduces the use of two different empirical equations for summer and winter which improves the reliability in summer temperature reconstructions. Further, all three species exhibit distinct growth variations in responding to regional climatic phenomena such as the Southern Annular Mode and the El Niño southern oscillation. Both Echyridella menziesii and Diplodon chilensis patagonicus show a distinctive reduction in growth during El Niño years contrary to tree ring data from these regions. Finally, fossil Diplodon chilensis patagonicus shells are used to evaluate the environmental conditions during medieval times (1200 - 1350 cal. yr. BP) and identified the medieval…

Advisors/Committee Members: Macquarie University. Department of Earth and Planetary Sciences.

Subjects/Keywords: Bivalves – Ecology; freshwater; oxygen isotopes; Sr/Ca

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APA (6^th Edition):

Herath, H. M. D. V. (2018). Bivalve shells as paleo-proxy archives: assessment of the usefulness as environmental and climatic recorders in the Southern Hemisphere. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1274033

Chicago Manual of Style (16^th Edition):

Herath, Herath Mudiyanselage Dilmi Vindya. “Bivalve shells as paleo-proxy archives: assessment of the usefulness as environmental and climatic recorders in the Southern Hemisphere.” 2018. Doctoral Dissertation, Macquarie University. Accessed January 23, 2021. http://hdl.handle.net/1959.14/1274033.

MLA Handbook (7^th Edition):

Herath, Herath Mudiyanselage Dilmi Vindya. “Bivalve shells as paleo-proxy archives: assessment of the usefulness as environmental and climatic recorders in the Southern Hemisphere.” 2018. Web. 23 Jan 2021.

Vancouver:

Herath HMDV. Bivalve shells as paleo-proxy archives: assessment of the usefulness as environmental and climatic recorders in the Southern Hemisphere. [Internet] [Doctoral dissertation]. Macquarie University; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1959.14/1274033.

Council of Science Editors:

Herath HMDV. Bivalve shells as paleo-proxy archives: assessment of the usefulness as environmental and climatic recorders in the Southern Hemisphere. [Doctoral Dissertation]. Macquarie University; 2018. Available from: http://hdl.handle.net/1959.14/1274033

Brno University of Technology

8. Vystrčil, Marek. Srovnání VFA a CFA: VFA and CFA comparison.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/1313

► This bachelor's thesis is focused on comparison of operational amplifiers structures with voltage (VFA) and current (CFA) feedback. In the theoretical part there is an… (more)

Subjects/Keywords: VFA; CFA; CMMR; SR; frekvenční chrakteristika; VFA; CFA; CMMR; SR; frequency response

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APA (6^th Edition):

Vystrčil, M. (2019). Srovnání VFA a CFA: VFA and CFA comparison. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/1313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vystrčil, Marek. “Srovnání VFA a CFA: VFA and CFA comparison.” 2019. Thesis, Brno University of Technology. Accessed January 23, 2021. http://hdl.handle.net/11012/1313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vystrčil, Marek. “Srovnání VFA a CFA: VFA and CFA comparison.” 2019. Web. 23 Jan 2021.

Vancouver:

Vystrčil M. Srovnání VFA a CFA: VFA and CFA comparison. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11012/1313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vystrčil M. Srovnání VFA a CFA: VFA and CFA comparison. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/1313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of St. Andrews

9. Barber, Mark E. Uniaxial stress technique and investigations into correlated electron systems .

Degree: 2017, University of St. Andrews

URL: http://hdl.handle.net/10023/15429

► In the repertoire of an experimental condensed matter physicist, the ability to tune continuously through features in the electronic structure and to selectively break point-group… (more)

▼ In the repertoire of an experimental condensed matter physicist, the ability to tune continuously through features in the electronic structure and to selectively break point-group symmetries are both valuable techniques. The experimental technique at the heart of this dissertation, uniaxial stress, can do both such things. The thesis will start with a thorough discussion of our new technique, which was continually developed over the course of this work, presenting both its unique capabilities and also some guidance on the best working practices, before moving on to describe results obtained on two different strongly correlated electron materials. The first, Sr₂RuO₄, is an unconventional superconductor, whose order parameter has long been speculated to be odd-parity. Of interest to us is the close proximity of one of its three Fermi surfaces to a Van Hove singularity (VHs). Our results strongly suggest that we have been able to traverse the VHs, inducing a topological Lifshitz transition. T[sub]c is enhanced by a factor ~2.3 and measurements of H[sub](c2) open the possibility that optimally strained Sr₂RuO₄ has an even-parity, rather than odd-parity, order parameter. Measurements of the normal state properties show that quasiparticle scattering is increased across all the bands and in all directions, and effects of quantum criticality are observed around the suspected Lifshitz transition. Sr₃Ru₂O₇ has a metamagnetic quantum critical endpoint, which in highly pure samples is masked by a novel phase. Weak in-plane magnetic fields are well-known to induce strong resistive anisotropy in the novel phase, leading to speculation that a spontaneous, electronically driven lowering of symmetry occurs. Using magnetic susceptibility and resistivity measurements we can show that in-plane anisotropic strain also reveals the strong susceptibility to electronic anisotropy. However, the phase diagram that these pressure measurements reveal is consistent only with large but finite susceptibility, and not with spontaneous symmetry reduction. Advisors/Committee Members: Mackenzie, Andrew (advisor).

Subjects/Keywords: Uniaxial stress; Strain; Superconductivity; Van Hove singularity; Quantum criticality; Sr₂RuO₄; Sr₃Ru₂O₇

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APA (6^th Edition):

Barber, M. E. (2017). Uniaxial stress technique and investigations into correlated electron systems . (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/15429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Barber, Mark E. “Uniaxial stress technique and investigations into correlated electron systems .” 2017. Thesis, University of St. Andrews. Accessed January 23, 2021. http://hdl.handle.net/10023/15429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Barber, Mark E. “Uniaxial stress technique and investigations into correlated electron systems .” 2017. Web. 23 Jan 2021.

Vancouver:

Barber ME. Uniaxial stress technique and investigations into correlated electron systems . [Internet] [Thesis]. University of St. Andrews; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10023/15429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barber ME. Uniaxial stress technique and investigations into correlated electron systems . [Thesis]. University of St. Andrews; 2017. Available from: http://hdl.handle.net/10023/15429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Trad, Georges. Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring.

Degree: Docteur es, Physique subatomique et astroparticules, 2015, Université Grenoble Alpes (ComUE)

URL: http://www.theses.fr/2015GREAY005

► La mesure de l’émittance transverse du faisceau est fondamentale pour tous les accélérateurs, et en particulier pour les collisionneurs, son évaluation precise étant essentielle pour… (more)

▼ La mesure de l’émittance transverse du faisceau est fondamentale pour tous les accélérateurs, et en particulier pour les collisionneurs, son évaluation precise étant essentielle pour maximiser la luminosité et ainsi la performance des faisceaux de collision.Le rayonnement synchrotron (SR) est un outil polyvalent pour le diagnostic non-destructif de faisceau, exploité au CERN pour mesurer la taille des faisceaux de protons des deux machines du complexe dont l’énergie est la plus élevée, le SPS et le LHC où l’intensité du faisceau ne permet plus les techniques invasives.Le travail de thèse documenté dans ce rapport s’est concentré sur la conception, le développement, la caractérisation et l’optimisation des moniteurs de taille de faisceau basés sur le SR. Cette étude est fondée sur un ensemble de calculs théoriques, de simulation numériques et d’expériences conduite au sein des laboratoires et accélérateurs du CERN. Un outil de simulation puissant a été développé, combinant des logiciels classiques de simulation de SR et de propagation optique, permettant ainsi la caractérisation complète d’un moniteur SR de la source jusqu’au détecteur.La source SR a pu être entièrement caractérisée par cette technique, puis les résultats validés par observation directe et par la calibration à basse énergie basée sur les mesures effectuées avec les wire-scanners (WS), qui sont la référence en terme de mesure de taille de faisceau, ou telles que la comparaison directe avec la taille des faisceaux obtenue par déconvolution de la luminosité instantanée du LHC.Avec l’augmentation de l’énergie dans le LHC (7TeV), le faisceau verra sa taille diminuer jusqu’à atteindre la limite de la technique d’imagerie du SR. Ainsi, plusieurs solutions ont été investiguées afin d’améliorer la performance du système: la sélection d’une des deux polarisations du SR, la réduction des effets liés à la profondeur de champ par l’utilisation de fentes optiques et l’utilisation d’une longueur d’onde réduite à 250 nm.En parallèle à l’effort de réduction de la diffraction optique, le miroir d’extraction du SR qui s’était avéré être la source principale des aberrations du système a été entièrement reconçu. En effet, la détérioration du miroir a été causée par son couplage EM avec les champs du faisceau, ce qui a conduit à une surchauffe du coating et à sa dégradation. Une nouvelle géométrie de miroir et de son support permettant une douce transition en termes de couplage d’impédance longitudinale dans le beam pipe a été définie et caractérisée par la technique dite du “streched wire”. Egalement, comme méthode alternative à l’imagerie directe, un nouveau moniteur basé sur la technique d’interférométrie à deux fentes du SR, non limité par la diffraction, a également été développé. Le principe de cette méthode est basé sur la relation directe entre la visibilité des franges d’interférence et la taille de faisceau.Comme l’emittance du faisceau est la donnée d’intérêt pour la performance du LHC, il est aussi important de caractériser avec précision l’optique du LHC à la… Advisors/Committee Members: Conto, Jean-Marie de (thesis director), Roncarolo, Federico (thesis director).

Subjects/Keywords: LHC; Radiation de synchrotron; SR; Instrumentation des faisceaux; Profil transverse; Emittance; SR imagerie; Interferométrie; SR interférence; Impédance longitudinale; Modulation de quadrupoles; Optique; Accélerateur; Accelerator; LHC; Synchrotron Radiation; SR; Beam Instrumentation; Beam size diagnostics; Emittance; SR imaging; Interferometry; K-Modulation; Machine optics measurement; 530

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Trad, G. (2015). Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring. (Doctoral Dissertation). Université Grenoble Alpes (ComUE). Retrieved from http://www.theses.fr/2015GREAY005

Chicago Manual of Style (16^th Edition):

Trad, Georges. “Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring.” 2015. Doctoral Dissertation, Université Grenoble Alpes (ComUE). Accessed January 23, 2021. http://www.theses.fr/2015GREAY005.

MLA Handbook (7^th Edition):

Trad, Georges. “Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring.” 2015. Web. 23 Jan 2021.

Vancouver:

Trad G. Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring. [Internet] [Doctoral dissertation]. Université Grenoble Alpes (ComUE); 2015. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2015GREAY005.

Council of Science Editors:

Trad G. Développement et optimisation des diagnostiques des faisceaux du LHC et du SPS basé sur le suivi de la lumière synchrotron : Development and Optimization of the LHC and the SPS Beam Diagnostics Based on Synchrotron Radiation Monitoring. [Doctoral Dissertation]. Université Grenoble Alpes (ComUE); 2015. Available from: http://www.theses.fr/2015GREAY005

Universidade do Estado do Rio de Janeiro

11. Hugo Tavares Machado. Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr.

Degree: Master, 2010, Universidade do Estado do Rio de Janeiro

URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;

► A área estudada está inserida na Faixa Ribeira, Segmento Central da Província Mantiqueira (Almeida et al., 1973, 1977, 1981), que representa um cinturão de dobramentos… (more)

▼ A área estudada está inserida na Faixa Ribeira, Segmento Central da Província Mantiqueira (Almeida et al., 1973, 1977, 1981), que representa um cinturão de dobramentos e empurrões gerado no Neo-proterozóico/Cambriano, durante a Orogênese Brasiliana, na borda sul/sudeste do Cráton do São Francisco (Almeida, 1971, 1977; Cordani et al., 1967, 1973; Cordani & Brito Neves, 1982; Teixeira & Figueiredo, 1991). Neste contexto, o Complexo Quirino é o embasamento retrabalhado do Terreno Paraíba do Sul (Heilbron et al., 2004). O Complexo Quirino é formado por extensos corpos de ortognaisses foliados a homogêneos, leuco a mesocráticos, de granulometria média à grossa, composicionalmente variando entre granitóides tonalíticos/granodioríticos a graníticos, e apresentando enclaves de rochas ultramáficas, máficas e cálcio-silicáticas (ricas em tremolita). Os ortognaisses tonalíticos/granodioríticos apresentam porfiroblastos de plagioclásio e a hornblenda como máfico principal, contrastando com os de composição granítica que apresentam porfiroblastos de K-feldspato e biotita predominante. Como acessórios aparecem zircão, titanita, apatita e epidoto. Também estão associados a estes ortognaisses, granitóides neoproterozóicos que formam corpos individualizados ou lentes anatéticas no conjunto paleoproterozóico. Estes são compostos predominantemente por biotita gnaisse e hornblenda-biotita gnaisse. A análise litogeoquímicas dos ortognaisses do Complexo Quirino demonstrou a existência de duas séries magmáticas distintas. A primeira pertencente à série cálcio-alcalina de alto-K apresenta uma composição mais expandida granítica-adamelítica/granodioritica/tonalítica e é correlacionável aos bt-ortognaisses e alguns hb-bt-ortognaisses. Os ortognaisses da série médio-K apresentam composição predominantemente tonalítica, sendo correlacionáveis à maioria dos hornblenda-biotita gnaisses. Enclaves lenticulares de metapiroxeníticos e anfibolíticos ocorrem em muitos afloramentos. Também ocorrem granitóides neoproterozóicos de composição graníticas a quartzo-monzoníticas O estudo isotópico de Sm-Nd e Sr demonstrou que os ortognaisses da série cálcio-alcalina de alto-K e aqueles da série cálcio-alcalina de médio-K possuem idades modelo TDM variando entre paleoproterozóicas a arqueanas, consistentes com dados U-Pb em zircão publicados na literatura. A série cálcio-alcalina de alto-K é mais antiga (2308 9,2 Ma a 2185 8 Ma) do que a série calcio-alcalina de médio-K (2169 3 a 2136 14 Ma) e a existência de zircões herdados com idades mínimas de 2846 Ma e 2981 Ma para série de médio-K e 3388 16 para série de alto-K. Os granitóides brasilianos possuem idades de cristalização neoproterozóica correlacionada a Orogênese Brasiliana (602 a 627 Ma) (Viana, 2008; Valladares et al., 2002)./Com base nos dados de Sr e Sm-Nd foi possível caracterizar 4 grupos distintos. Os grupos 1 e 2 são formados por rochas de idade paleoproterozóica (2,1 a 2,3 Ga) com idades modelo TDM variando de 2,9 e 3,4 Ga, εNd entre -8,1 e -5,8 e 87Sr/86Sr(t) = 0,694707 (Grupo 1) e TDM… Advisors/Committee Members: Claudio de Morisson Valeriano, Sílvia Regina de Medeiros, Rubem Porto Junior, Claudia Sayão Valladares.

Subjects/Keywords: Complexo Quirino; Geoquímica isotópica de Sm-Nd e Sr; Quirino Complex; Sm-Nd and Sr geochemistry; GEOQUIMICA

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APA (6^th Edition):

Machado, H. T. (2010). Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;

Chicago Manual of Style (16^th Edition):

Machado, Hugo Tavares. “Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr.” 2010. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed January 23, 2021. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;.

MLA Handbook (7^th Edition):

Machado, Hugo Tavares. “Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr.” 2010. Web. 23 Jan 2021.

Vancouver:

Machado HT. Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2010. [cited 2021 Jan 23]. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;.

Council of Science Editors:

Machado HT. Evolução geológica do Complexo Quirino, Terreno Paraíba do Sul, Setor Central da Faixa Ribeira, com base em dados isotópicos de Sm-Nd e Sr. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2010. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2289 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2290 ; http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2291 ;

Université Montpellier II

12. Fernando, Céline. Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster.

Degree: Docteur es, Biologie Santé, 2011, Université Montpellier II

URL: http://www.theses.fr/2011MON20197

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Les protéines SR, qui constituent une famille conservée de facteurs liant l'ARN, jouent un rôle majeur dans l'épissage des ARN et en particulier dans la… (more)

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Les protéines SR, qui constituent une famille conservée de facteurs liant l'ARN, jouent un rôle majeur dans l'épissage des ARN et en particulier dans la régulation de l'épissage alternatif. Certaines protéines SR peuvent également participer à l'élongation de la transcription, l'export, la stabilité ou la traduction des ARNm. Ces différents rôles soulignent l'importance des protéines SR en tant que régulateurs clés du métabolisme des ARNm et de l'expression des gènes. Des altérations de leur quantité ou de leur activité peuvent induire des défauts développementaux ou des pathologies telles que des tumeurs. Afin de mieux comprendre les fonctions et les mécanismes de régulation des protéines SR in vivo, je me suis intéressée à la protéine SR B52 chez D. melanogaster. En réalisant un crible génétique, nous avons identifié des protéines capables de sauver les phénotypes induits par la surexpression de B52 in vivo. L'une de ces protéines est l'ADN Topoisomérase I (Topo I). La Topo I possède à la fois une activité topoisomérase impliquée dans la relaxation de l'ADN, et une activité kinase capable de phosphoryler les protéines SR. Nous avons montré que B52 est impliquée dans le recrutement de la Topo I aux sites actifs de transcription, en particulier lors de l'induction des gènes heat shock, et que ces protéines jouent un rôle dans la libération de l'ARN hsp70 de son site de transcription et dans l'extinction de sa transcription. Une autre protéine capable de sauver les phénotypes induits par la surexpression de B52 est Brain tumor, un répresseur post-transcriptionnel de l'expression de myc. Myc est un régulateur clé de la croissance chez la drosophile. Nos résultats révèlent un effet positif de B52 sur la croissance cellulaire dans certains tissus, et sur l'expression de dmyc. Nous montrons également que le niveau de B52 affecte l'épissage alternatif de plusieurs gènes impliqués dans la croissance, dont le coactivateur transcriptionnel Yorkie et le facteur d'initiation de la traduction eIF4E. Ainsi, nos travaux suggèrent que la protéine SR B52 pourrait coordonner un ensemble d'évènements d'épissage dans des voies de signalisation impliquées dans la croissance cellulaire.

SR proteins, which constitute a conserved family of RNA-binding factors, play a key role in RNA splicing and particularly in alternative splicing regulation. In addition, some SR proteins have been shown to participate in transcription elongation, mRNA export, mRNA stability and mRNA translation. These wide-ranging roles of SR proteins highlight their importance as pivotal regulators of mRNA metabolism and gene expression. Alteration of their expression level or activity can induce developmental defects or pathologies such as tumors. To better understand SR proteins functions and how they are regulated in vivo, I studied a major SR protein in Drosophila melanogaster called B52. Using a genetic screen, we identified proteins that can rescue the phenotypes induced by B52 overexpression. Among them is the DNA Topoisomerase I (Topo I). Topo I carries two…

Advisors/Committee Members: Tazi, Jamal (thesis director).

Subjects/Keywords: Protéines SR; Épissage alternatif; Drosophile; Topoisomérase I; Croissance cellulaire; SR proteins; Alternative splicing; Drosophila melanogaster; Topoisomerase I; Cell growth

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fernando, C. (2011). Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster. (Doctoral Dissertation). Université Montpellier II. Retrieved from http://www.theses.fr/2011MON20197

Chicago Manual of Style (16^th Edition):

Fernando, Céline. “Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster.” 2011. Doctoral Dissertation, Université Montpellier II. Accessed January 23, 2021. http://www.theses.fr/2011MON20197.

MLA Handbook (7^th Edition):

Fernando, Céline. “Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster.” 2011. Web. 23 Jan 2021.

Vancouver:

Fernando C. Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster. [Internet] [Doctoral dissertation]. Université Montpellier II; 2011. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2011MON20197.

Council of Science Editors:

Fernando C. Caractérisation de nouvelles fonctions du facteur d’épissage B52 dans la transcription et la croissance cellulaire chez la drosophile : Characterization of new functions of the splicing factor B52 in transcription and cell growth in Drosophila melanogaster. [Doctoral Dissertation]. Université Montpellier II; 2011. Available from: http://www.theses.fr/2011MON20197

Virginia Commonwealth University

13. Bajpai, Saurabh. ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII.

Degree: MS, Physiology, 2009, Virginia Commonwealth University

URL: https://doi.org/10.25772/770D-5D08 ; https://scholarscompass.vcu.edu/etd/1711

► Reduction of cholesterol ester (CE) from lipid burden lesion-associated macrophage foam cells has been shown to reduce plaque volumes. Hydrolysis of CE to free cholesterol… (more)

Subjects/Keywords: CEH; SR-BI; SR-BII; atherosclerosis; Life Sciences; Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bajpai, S. (2009). ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/770D-5D08 ; https://scholarscompass.vcu.edu/etd/1711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bajpai, Saurabh. “ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII.” 2009. Thesis, Virginia Commonwealth University. Accessed January 23, 2021. https://doi.org/10.25772/770D-5D08 ; https://scholarscompass.vcu.edu/etd/1711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bajpai, Saurabh. “ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII.” 2009. Web. 23 Jan 2021.

Vancouver:

Bajpai S. ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII. [Internet] [Thesis]. Virginia Commonwealth University; 2009. [cited 2021 Jan 23]. Available from: https://doi.org/10.25772/770D-5D08 ; https://scholarscompass.vcu.edu/etd/1711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bajpai S. ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII. [Thesis]. Virginia Commonwealth University; 2009. Available from: https://doi.org/10.25772/770D-5D08 ; https://scholarscompass.vcu.edu/etd/1711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Montpellier II

14. Lopez Mejia, Isabel Cristina. Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford.

Degree: Docteur es, Biologie Santé, 2011, Université Montpellier II

URL: http://www.theses.fr/2011MON20077

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Le vieillissement est un processus complexe qui peut être influencé par des facteurs environnementaux et génétiques. Le syndrome progéroïde de Hutchinson-Gilford (HGPS ou progéria) fourni… (more)

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Le vieillissement est un processus complexe qui peut être influencé par des facteurs environnementaux et génétiques. Le syndrome progéroïde de Hutchinson-Gilford (HGPS ou progéria) fourni une preuve irréfutable de l'implication de l'épissage dans le processus de vieillissement. La progéria est une maladie due à une mutation hétérozygote silencieuse qui renforce l'utilisation d'un site 5' d'épissage interne dans l'exon 11 de l'ARN pré-messager LMNA, ce qui entraîne la production d'une protéine tronquée appelée «progérine». Le défaut d'épissage du gène LMNA a aussi lieu dans les cellules de personnes âgées, et la correction de ce défaut permet un sauvetage partiel des anomalies qu'il provoque. Ceci fait de l'ARN pré-messager LMNA une cible très attractive pour des thérapies ayant pour but de corriger l'épissage. Mes travaux de thèse ont montré que cette mutation silencieuse active un site d'épissage 5' dans l'exon 11 en changeant la structure de l'ARN. Ce changement de structure facilite l'interaction de la snRNP U1 avec le site d'épissage et permet ainsi sa modulation par les protéines SR SRSF1 et SRSF6. J'ai aussi participé à la caractérisation d'un nouveau modèle murin qui reproduit l'altération d'épissage des patients HGPS au niveau du gène Lmna souris. De façon surprenante, ce modèle récapitule tous les phénotypes du syndrome HGPS. Les souris homozygotes, dans lesquelles la plupart de la lamine A est convertie en progérine, ne vivent pas plus de 5 mois, alors que les souris hétérozygotes vivent autour d'un an et que les contrôles sauvages vivent deux ans. Étonnamment, des souris qui n'expriment ni la lamine A ni la progérine, mais uniquement de la lamine C, vivent plus longtemps que les souris contrôle, suggérant que la lamine A et la progérine, qui sont produites à partir du même transcrit, participent à la régulation de la durée de la vie. De plus, la caractérisation initiale des souris HGPS indique que l'expression de la progérine est délétère pour le tissu adipeux, établissant ainsi un lien inattendu entre l'épuisement du tissu adipeux et le vieillissement accéléré. Ce nouveau modèle murin est actuellement en train d'être utilisé pour des approches de modulation de l'épissage aberrant du gène LMNA avec des oligonucléotides antisense et des petites molécules chimiques.

Aging is a complex cellular and organismal process that can be influenced by environmental as well as genetic factors. A striking proof-of-concept that splicing regulation plays an important role in the aging process is provided by Hutchinson-Gilford progeria syndrome (HGPS), a disease caused by a heterozygous silent mutation that enhances the use of an internal 5' splice site in exon 11 of LMNA pre-mRNA and leads to the production of a truncated protein called “progerin”. The LMNA splicing defect also occurs with increased frequency in cells from healthy aged individuals and correction of this defect leads to partial reversal of age-related dysfunction. This makes LMNA pre-mRNA an attractive target for splicing-correction therapies. During my…

Advisors/Committee Members: Tazi, Jamal (thesis director).

Subjects/Keywords: Epissage alternatif; Proteines SR; Syndrome progéroïde de Hutchinson-Gilford; Vieillissement; Lmna; Alternative splicing; SR proteins; Hutchinson-Gilford Progeria Syndrome; Aging; Lmna

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lopez Mejia, I. C. (2011). Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford. (Doctoral Dissertation). Université Montpellier II. Retrieved from http://www.theses.fr/2011MON20077

Chicago Manual of Style (16^th Edition):

Lopez Mejia, Isabel Cristina. “Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford.” 2011. Doctoral Dissertation, Université Montpellier II. Accessed January 23, 2021. http://www.theses.fr/2011MON20077.

MLA Handbook (7^th Edition):

Lopez Mejia, Isabel Cristina. “Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford.” 2011. Web. 23 Jan 2021.

Vancouver:

Lopez Mejia IC. Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford. [Internet] [Doctoral dissertation]. Université Montpellier II; 2011. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2011MON20077.

Council of Science Editors:

Lopez Mejia IC. Alternative splicing of LMNA gene : lessons from a new mouse model of Hutchinson-Gilfort progeria syndrome : L’épissage alternatif du gène LMNA : leçons d’un nouveau modèle de souris qui reproduit le syndrome progéroïde de Hutchinson-Gilford. [Doctoral Dissertation]. Université Montpellier II; 2011. Available from: http://www.theses.fr/2011MON20077

15. Juillard, Franceline. Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20.

Degree: Docteur es, Sciences de la vie, 2011, Lyon, École normale supérieure

URL: http://www.theses.fr/2011ENSL0621

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La protéine EB2 du virus d'Epstein-Barr (EBV) est une protéine du cycle réplicatif du virus indispensable à la production de particules virales. Elle permet l’accumulation… (more)

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La protéine EB2 du virus d'Epstein-Barr (EBV) est une protéine du cycle réplicatif du virus indispensable à la production de particules virales. Elle permet l’accumulation dans le cytoplasme de certains ARNm viraux issus de gènes dépourvus d’intron. Pour mettre en évidence les mécanismes qui permettent à EB2 d’exporter ses ARNm cibles dans le cytoplasme, nous avons identifié différents partenaires cellulaires d’EB2 et nous avons étudié certaines de ces interactions d’un point de vue fonctionnel. Nous avons pu montrer qu’EB2 recrute directement le facteur général d'export des ARNm, TAP/NXF1, ce qui lui permet d’être exportée du noyau vers le cytoplasme. Puis nous avons montré qu’EB2 interagit avec SRp20, une protéine impliquée notamment dans la régulation de l'épissage et l'export des ARNm cellulaires. Cette interaction entre EB2 et SRp20 est indispensable pour l’accumulation dans le cytoplasme de certains ARNm cibles d’EB2, notamment parce que SRp20 semble permettre le recrutement d'EB2 sur ces ARNm. Enfin, nous avons montré qu’EB2 forme un dimère et nous avons caractérisé le domaine de la protéine responsable de cette interaction. La dimérisation d'EB2 semble essentielle pour que la protéine interagisse avec certains de ses partenaires comme SRp20 ou encore REF.

The Epstein-Barr virus (EBV) protein EB2 is an early protein essential for the production of infectous virions. EB2 allows the cytoplasmic accumulation of a subset of viral mRNAs derived from intronless genes. To highlight the mecanisms by which EB2 exports his targets mRNA, we identified cellular partners and studied the functional role of some of these interactions. We showed that EB2 recruits directly the cellular mRNA export factor TAP/NXF1 and this interaction allows EB2’s shuttling between the nucleus and the cytoplasm. The we showed that EB2 interacts with SRp20, a cellular protein implicated in splicing regulation and mRNA export. This interaction is essential for the efficient cytoplasmic accumulation of some EB2 target mRNAs, partly because SRp20 appears to be able to recruit EB2 on these mRNAs. Then we showed that EB2 dimerises and we characterized the domain necessary for this interaction. This dimerisation appears to be essential for EB2’s interaction with several partners, including SRp20 and REF.

Advisors/Committee Members: Gruffat, Henri (thesis director).

Subjects/Keywords: Export des ARNm; TAP/NXF1; Protéines SR; SRp20; MRNAs export; TAP/NXF1; SR protein; SRp20; Epstein-Barr Virus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Juillard, F. (2011). Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20. (Doctoral Dissertation). Lyon, École normale supérieure. Retrieved from http://www.theses.fr/2011ENSL0621

Chicago Manual of Style (16^th Edition):

Juillard, Franceline. “Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20.” 2011. Doctoral Dissertation, Lyon, École normale supérieure. Accessed January 23, 2021. http://www.theses.fr/2011ENSL0621.

MLA Handbook (7^th Edition):

Juillard, Franceline. “Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20.” 2011. Web. 23 Jan 2021.

Vancouver:

Juillard F. Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20. [Internet] [Doctoral dissertation]. Lyon, École normale supérieure; 2011. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2011ENSL0621.

Council of Science Editors:

Juillard F. Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20 : Mechanisms allowing cytoplasmic accumulation of viral mRNAs by the Epstein-Barr virus protein EB2 : role of the cellular factors TAP/NXF1 and SRp20. [Doctoral Dissertation]. Lyon, École normale supérieure; 2011. Available from: http://www.theses.fr/2011ENSL0621

16. Amor, Souheila. Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease.

Degree: Docteur es, Sciences de la vie, spécialité Virologie, 2010, Université François-Rabelais de Tours

URL: http://www.theses.fr/2010TOUR4045

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La télomérase, composée de l‘ARN TR et de la protéine TERT, responsable du maintien de la longueur des télomères est surexprimée dans la majorité des… (more)

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La télomérase, composée de l‘ARN TR et de la protéine TERT, responsable du maintien de la longueur des télomères est surexprimée dans la majorité des cellules cancéreuses. La dynamique de la régulation post-transcriptionnelle de TERT sur l‘activation de la télomérase a été étudiée dans le modèle de lymphomagenèse induite par l‘herpesvirus oncogène aviaire de la maladie de Marek. L‘augmentation de l‘activité télomérase des TCD4+ lors de l‘apparition des lymphomes résulte d‘une hausse du transcrit constitutif et de celle des transcrits cibles de la voie de dégradation du « non-sense mediated decay » (NMD) alors que l‘activité télomérase basale des TCD4+ non infectés est contrôlée par les isoformes dominantes négatives. La caractérisation de la protéine virale ICP27 de MDV-1, régulateur potentiel de l‘épissage des gènes, qui s‘exprime pendant la phase de réplication lytique du virus a complété cette étude. ICP27 est capable de co-localiser et d‘interagir avec les protéines SR du splicéosome ainsi que de réguler négativement l‘épissage des gènes cellulaire TERT et viral vIL8 de manière similaire à ICP27 de l‘herpesvirus simplex 1. Le modèle naturel de lymphomagenèse induite par MDV-1 a permis d‘établir pour la première fois un lien entre l‘activation de la télomérase in vivo et la régulation de l‘épissage de TERT, à laquelle pourrait participer la protéine virale ICP27.

The telomerase, consisting of an RNA template (TR) and a reverse transcriptase (TERT) maintains telomere length and is highly expressed in the majority of cancer cells. The splicing regulation of TERT was studied in Marek‘s disease (MD), a natural lymphoma induced by MDV-1, the avian MD herpesvirus. Telomerase activation observed in TCD4+ cells at the onset of MD lymphoma was due to an increase of constitutively spliced and « non-sense mediated decay » (NMD) while basal telomerase activity of non infected TCD4+ cells was controlled by dominant negative isoforms. In addition, the viral protein ICP27, a putative regulator of splicing, expressed during MDV-1 lytic infection was characterised. ICP27 co-localized and interacted with spliceosome SR proteins and negatively controlled splicing of TERT and vIL8 viral gene in a way similar to that of ICP27 of herpesvirus simplex 1. The MD model provides the only data on the in vivo regulation of TERT splicing, possibly mediated by ICP27, and telomerase activation during lymphomagenesis induced by a herpesvirus in its natural host.

Advisors/Committee Members: Laurent, Sylvie (thesis director).

Subjects/Keywords: Herpesvirus; Maladie de Marek; Oncogenèse; Épissage; NMD; Télomérase; ICP27; Protéines SR; Herpesvirus; Marek Disease; Oncogenesis; Splicing; NMD; Telomerase; ICP27; SR proteins

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amor, S. (2010). Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease. (Doctoral Dissertation). Université François-Rabelais de Tours. Retrieved from http://www.theses.fr/2010TOUR4045

Chicago Manual of Style (16^th Edition):

Amor, Souheila. “Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease.” 2010. Doctoral Dissertation, Université François-Rabelais de Tours. Accessed January 23, 2021. http://www.theses.fr/2010TOUR4045.

MLA Handbook (7^th Edition):

Amor, Souheila. “Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease.” 2010. Web. 23 Jan 2021.

Vancouver:

Amor S. Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease. [Internet] [Doctoral dissertation]. Université François-Rabelais de Tours; 2010. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2010TOUR4045.

Council of Science Editors:

Amor S. Régulation de l'épissage de la télomérase lors de la lymphomagenèse induite par l'herpèsvirus oncogène aviaire de la maladie de marek : Regulation of splicing of the avian telomerase gene during lymphomagenesis induced by an avian oncogenic herpesvirus of Marek disease. [Doctoral Dissertation]. Université François-Rabelais de Tours; 2010. Available from: http://www.theses.fr/2010TOUR4045

17. Espinosa Delgado, Sara. Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development.

Degree: Docteur es, Physiopathologie, 2017, Université Toulouse III – Paul Sabatier

URL: http://www.theses.fr/2017TOU30053

► L’effet athéroprotecteur des Lipoprotéines de Haute Densité (HDL) est principalement attribué à leur rôle clé dans Transport Retour du Cholestérol (RCT), un processus par lequel… (more)

▼ L’effet athéroprotecteur des Lipoprotéines de Haute Densité (HDL) est principalement attribué à leur rôle clé dans Transport Retour du Cholestérol (RCT), un processus par lequel le cholestérol excédentaire des cellules périphériques est capté par les particules HDL pour être amené au foie où il sera préférentiellement sécrété dans les voies biliaires, puis excrété dans les fèces. Deux voies indépendantes ont été identifiées comme étant impliquées dans l’endocytose hépatique du HDL. La première est la voie ecto-F1-ATPase/P2Y13 dans laquelle l’apoA-I (apolipoprotéine majoritaire des HDL) se lie à la F1-ATPase exprimé à la surface des hépatocytes (ecto-F1-ATPase) et stimule l’hydrolyse d’ATP en ADP. L’ADP ainsi généré active le récepteur purinergique P2Y13 pour stimuler l’endocytose de l’holoparticule HDL (protéines + lipides) via un troisième récepteur différent de SR-BI. Les souris invalidées pour P2Y13 présentent une diminution des sécrétions de lipides biliaires accompagnée d’une diminution du RCT des macrophages vers les fèces sous régime normolipidique. Un régime riche en cholestérol (1.25% cholestérol) accentue ce phénotype. La voie SR-BI, quant à elle, est responsable de la captation sélective du cholestérol estérifié des HDL par le foie. Les souris invalidées pour SR-BI spécifiquement au niveau du foie (SR-BI KOfoie) présentent une hypercholestérolémie principalement attribuée à une augmentation du HDL-C et développent des plaques d’athérosclérose sous régime hypercholestérolémique. Dans une étude récente, nous avons montré que l’invalidation de P2Y13 dans le modèle murin proathérogène apoE KO induit une augmentation du développement d’athérosclérose associée à une diminution des sécrétions de lipides biliaires et du RCT des macrophages vers les fèces. De plus, dans ces souris, l’expression hépatique transcriptionnelle et protéique de SR-BI étaient fortement augmentées par rapport aux souris apoE KO, suggérant qu’un possible mécanisme de compensation pourrait exister entre les récepteurs P2Y13 et SR-BI. L’objectif de ma thèse a été d’étudier la contribution respective des récepteur P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l’athérosclérose. Nous avons croisé des souris P2Y13 KO avec des souris SR-BI KOfoie et nous avons obtenu des souris doublement invalidées (P2Y13 x SR-BIfoie dKO). Le phénotype métabolique des souris dKO a été étudié sous régime normolipidique et hypercholestérolémique et le développement d’athérosclérose sous régime hypercholestérolémique. Par rapport aux souris sauvages, les souris dKO sous régime normolipidique, présentent une augmentation du cholestérol plasmatique similaire à celle observée chez les souris SR-BI KOfoie, principalement imputable à une augmentation du HDL-C. Les souris dKO, mais pas les souris SR-BI KO, montrent une diminution des sécrétions de lipides biliaires comparable à celle observée chez les souris P2Y13 KO. Ce phénotype métabolique observé chez les souris dKO est accentué sous régime hypercholestérolémique et est associé à une augmentation… Advisors/Committee Members: Martinez, Laurent (thesis director), Lichtenstein, Laetitia (thesis director).

Subjects/Keywords: HDL; P2Y13; SR-BI; Transport retour du cholestérol; Athérosclérose; HDL; P2Y13; SR-BI; Reverse cholesterol transport; Atherosclerosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Espinosa Delgado, S. (2017). Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2017TOU30053

Chicago Manual of Style (16^th Edition):

Espinosa Delgado, Sara. “Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development.” 2017. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed January 23, 2021. http://www.theses.fr/2017TOU30053.

MLA Handbook (7^th Edition):

Espinosa Delgado, Sara. “Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development.” 2017. Web. 23 Jan 2021.

Vancouver:

Espinosa Delgado S. Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2017. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2017TOU30053.

Council of Science Editors:

Espinosa Delgado S. Contribution respective des récepteurs P2Y13 et SR-BI dans le métabolisme du HDL-C et le développement de l'athérosclérose : Respective contribution of P2Y13 and SR-BI receptors in HDL-C metabolism and atherosclerosis development. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2017. Available from: http://www.theses.fr/2017TOU30053

Vilnius Gediminas Technical University

18. Stasionytė, Rita. Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR alternatyvaus splaisingo reguliacija.

Degree: Master, Biochemistry, 2009, Vilnius Gediminas Technical University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;

►

Baigiamojo magistro darbo tyrimo objektas – pelės HIF-3α baltymą koduojantis genas ir jo pre-iRNR alternatyvaus splaisingo procesas. Darbe pristatomas alternatyvaus HIF-3α pre-iRNR splaisingo reguliacijos tyrimas,… (more)

▼

Baigiamojo magistro darbo tyrimo objektas – pelės HIF-3α baltymą koduojantis genas ir jo pre-iRNR alternatyvaus splaisingo procesas. Darbe pristatomas alternatyvaus HIF-3α pre-iRNR splaisingo reguliacijos tyrimas, atliekant pre-iRNR splaisingo reakcijas in vitro HeLa ląstelių branduolių ekstraktuose. Nustatyta, kad hipoksinėmis sąlygomis augintų HeLa ląstelių branduolių ekstrakte alternatyvūs 3ʹ splaisingo taikiniai splaisingo metu naudojami neefektyviai lyginant su jų panaudojimu normoksinėmis sąlygomis augintų HeLa ląstelių branduolių ekstrakte. Ištirta SR baltymų įtaka alternatyvaus HIF-3α pre-iRNR splaisingo procesui ir nustatyta, kad SR baltymų funkcinis aktyvumas kinta priklausomai nuo deguonies kiekio ląstelinėje aplinkoje. Palyginus U2AF65 splaisingo faktoriaus kiekį hipoksinėmis ir normoksinėmis sąlygomis augintų HeLa ląstelių branduolių ekstraktuose, nustatyta, kad šio baltymo kiekis sumažėja hipoksinėmis sąlygomis. Atlikti tyrimai yra svarbūs suprantant priklausomai nuo deguonies kiekio aplinkoje ląstelėje vykstančius pokyčius pre-iRNR splaisingo lygmenyje, kuriant naujus vėžinių auglių gydymo metodus ir atrandant naujus vėžinius žymenis.

The object of this final work was mouse hypoxia inducible factor - 3α gene and its pre-mRNA alternative splicing process. During the course of the work alternative pre-mRNA splicing regulation of HIF-3α was investigated. In vitro reactions of pre-mRNA splicing were performed in under normoxic or hypoxic oxygen conditions cultivated HeLa cells nuclear extracts. There was found that in hypoxic HeLa cells nuclear extract alternative 3ʹ splice sites are used ineffectively compared with their usage in normoxic HeLa cells nuclear extract. The influence of SR proteins purified from HeLa cells on alternative HIF-3α pre-mRNA splicing was investigated. There was found that functional activity of SR proteins varies depending on oxygen tension in cellural environment. Also there was determined that amount of U2AF65 splicing factor in HeLa cells nuclear extracts is reduced by hypoxia. These investigations and results are important trying to understand the complex cell response to hypoxia, control pre-mRNA splicing changes processed under hypoxic conditions, create new methods for solid tumours treatment.

Advisors/Committee Members: Kanopka, Arvydas (Master’s thesis supervisor), Gedminienė, Genovaitė (Master’s thesis advisor), Sereikaitė, Jolanta (Master’s thesis reviewer).

Subjects/Keywords: Alternatyvus splaisingas; Hipoksija; Hipoksijos indukuojami faktoriai; Pre-iRNR; SR baltymai; Alternative splicing; Hypoxia; Hypoxia inducible factors; Pre-mRNA; SR proteins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stasionytė, Rita. (2009). Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR alternatyvaus splaisingo reguliacija. (Masters Thesis). Vilnius Gediminas Technical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Stasionytė, Rita. “Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR alternatyvaus splaisingo reguliacija.” 2009. Masters Thesis, Vilnius Gediminas Technical University. Accessed January 23, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Stasionytė, Rita. “Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR alternatyvaus splaisingo reguliacija.” 2009. Web. 23 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Stasionytė, Rita. Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR alternatyvaus splaisingo reguliacija. [Internet] [Masters thesis]. Vilnius Gediminas Technical University; 2009. [cited 2021 Jan 23]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Stasionytė, Rita. Hipoksijos indukuojamo faktoriaus - 3α pre-iRNR alternatyvaus splaisingo reguliacija. [Masters Thesis]. Vilnius Gediminas Technical University; 2009. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090703_115930-25555 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

19. Hesari, Mahdi. Electrogenerated Chemiluminescence of Gold Nanoclusters.

Degree: 2014, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/2200

► A series of monodispersed AuNCs including Au144(SR)60, Au38(SR)24 and Au25(SR)18z (z =1-, 0 and 1+, SR=2-phenylethanethiol) were prepared. All these nanoclusters showed molecule-like optical and… (more)

Subjects/Keywords: Electrochemistry; Electrogenerted chemiluminescence (ECL); Spooling ECL and PL spectroscopy; Gold nanoclusters; Au25(SR)18; Au38(SR)24.; Analytical Chemistry; Materials Chemistry

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hesari, M. (2014). Electrogenerated Chemiluminescence of Gold Nanoclusters. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2200

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hesari, Mahdi. “Electrogenerated Chemiluminescence of Gold Nanoclusters.” 2014. Thesis, University of Western Ontario. Accessed January 23, 2021. https://ir.lib.uwo.ca/etd/2200.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hesari, Mahdi. “Electrogenerated Chemiluminescence of Gold Nanoclusters.” 2014. Web. 23 Jan 2021.

Vancouver:

Hesari M. Electrogenerated Chemiluminescence of Gold Nanoclusters. [Internet] [Thesis]. University of Western Ontario; 2014. [cited 2021 Jan 23]. Available from: https://ir.lib.uwo.ca/etd/2200.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hesari M. Electrogenerated Chemiluminescence of Gold Nanoclusters. [Thesis]. University of Western Ontario; 2014. Available from: https://ir.lib.uwo.ca/etd/2200

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Langlois, Anne-Claire. Caractérisation des déterminants moléculaires impliqués dans l'entrée des sporozoïtes de Plasmodium dans les cellules hépatocytaires : Characterization of the molecular determinants involved in Plasmodium sporozoites entry into hepatocytic cells.

Degree: Docteur es, Biologie, 2019, Sorbonne université

URL: http://www.theses.fr/2019SORUS235

►

Les sporozoïtes de Plasmodium, l’agent du paludisme, sont transmis par les moustiques Anophèles et infectent le foie pour une première phase de réplication. Les mécanismes… (more)

▼

Les sporozoïtes de Plasmodium, l’agent du paludisme, sont transmis par les moustiques Anophèles et infectent le foie pour une première phase de réplication. Les mécanismes moléculaires impliqués dans l'invasion des hépatocytes restent méconnus. Deux récepteurs du virus de l'hépatite C (VHC), la tétraspanine CD81 et le récepteur Scavenger Receptor BI (SR-BI), jouent un rôle majeur dans l'entrée des sporozoïtes de Plasmodium dans les hépatocytes. CD81 et SR-BI définissent des voies d’entrée indépendantes et alternatives en fonction des espèces de Plasmodium. Un autre facteur d'entrée du VHC, le récepteur aux éphrines EphA2, a plus récemment été proposé comme facteur clé de l'infection hépatique. Nos travaux ont révélé que EphA2 n’est pas requis au cours de l’infection hépatique par les sporozoïtes, quelle que soit la voie d’entrée. D’autre part, nous avons montré que SR-BI murin est peu fonctionnel lors de l'infection par P. berghei par rapport à son homologue humain. À l’aide de constructions chimériques de SR-BI, nous avons pu démontrer le rôle des hélices apicales de SR-BI humain au cours de l’infection. Ces résultats suggèrent que cette région de la molécule pourrait interagir avec des ligands des sporozoïtes. Nos données ouvrent la voie vers une meilleure caractérisation des interactions moléculaires impliquées dans l'entrée des parasites de Plasmodium dans les hépatocytes.

Sporozoite forms of the malaria parasite Plasmodium are transmitted by mosquitoes and first infect the liver for an initial round of replication. The molecular mechanisms of sporozoite invasion of hepatocytes remain poorly understood. Two receptors of the Hepatitis C virus (HCV), the tetraspanin CD81 and the Scavenger Receptor BI (SR-BI), play an important role during entry of Plasmodium sporozoites into hepatocytic cells. CD81 and SR-BI operate independently during malaria liver infection, and receptor usage differs between different Plasmodium species. More recently, another HCV entry factor, the Ephrin receptor A2 (EphA2), was reported to play a key role during malaria liver infection. Using different inhibition techniques, we show that blocking EphA2 has no significant impact on P. yoelii or P. berghei host cell infection, irrespective of the entry pathway. On the other hand, our work revealed that murine SR-BI is poorly functional during P. berghei infection as compared to its human counterpart. Using a structure-guided strategy, we were able to locate the functional region of human SR-BI to the apical helices, suggesting that this region of the molecule could interact with sporozoite ligands. Altogether, these results pave the way toward a better characterization of the molecular mechanisms involved in Plasmodium sporozoite entry into hepatocytes.

Advisors/Committee Members: Silvie, Olivier (thesis director).

Subjects/Keywords: Paludisme; Plasmodium; Sporozoïte; Hépatocyte; Epha2; SR-BI; LIMP-2; CD36; Malaria; Plasmodium; Sporozoite; Hepatocyte; Epha2; SR-BI; LIMP-2; CD36; 616.9362

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Langlois, A. (2019). Caractérisation des déterminants moléculaires impliqués dans l'entrée des sporozoïtes de Plasmodium dans les cellules hépatocytaires : Characterization of the molecular determinants involved in Plasmodium sporozoites entry into hepatocytic cells. (Doctoral Dissertation). Sorbonne université. Retrieved from http://www.theses.fr/2019SORUS235

Chicago Manual of Style (16^th Edition):

Langlois, Anne-Claire. “Caractérisation des déterminants moléculaires impliqués dans l'entrée des sporozoïtes de Plasmodium dans les cellules hépatocytaires : Characterization of the molecular determinants involved in Plasmodium sporozoites entry into hepatocytic cells.” 2019. Doctoral Dissertation, Sorbonne université. Accessed January 23, 2021. http://www.theses.fr/2019SORUS235.

MLA Handbook (7^th Edition):

Langlois, Anne-Claire. “Caractérisation des déterminants moléculaires impliqués dans l'entrée des sporozoïtes de Plasmodium dans les cellules hépatocytaires : Characterization of the molecular determinants involved in Plasmodium sporozoites entry into hepatocytic cells.” 2019. Web. 23 Jan 2021.

Vancouver:

Langlois A. Caractérisation des déterminants moléculaires impliqués dans l'entrée des sporozoïtes de Plasmodium dans les cellules hépatocytaires : Characterization of the molecular determinants involved in Plasmodium sporozoites entry into hepatocytic cells. [Internet] [Doctoral dissertation]. Sorbonne université; 2019. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2019SORUS235.

Council of Science Editors:

Langlois A. Caractérisation des déterminants moléculaires impliqués dans l'entrée des sporozoïtes de Plasmodium dans les cellules hépatocytaires : Characterization of the molecular determinants involved in Plasmodium sporozoites entry into hepatocytic cells. [Doctoral Dissertation]. Sorbonne université; 2019. Available from: http://www.theses.fr/2019SORUS235

Brno University of Technology

21. Stránský, Jakub. Protismykové vlastnosti vozovek: Skid resistance of pavements.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/28908

► Bachelor’s thesis main purpose is to process the knowledge about skid resistance, its mesurement, the equipment used and its failures and suitable repairs of solid… (more)

Subjects/Keywords: Protismykové vlastnosti; mikrotextura; makrotextura; povrch vozovky; ztráta PVV; obnova PVV; Skid resistance; mircotexture; macrotexture; road surface; loss of SR; renewal SR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stránský, J. (2019). Protismykové vlastnosti vozovek: Skid resistance of pavements. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/28908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stránský, Jakub. “Protismykové vlastnosti vozovek: Skid resistance of pavements.” 2019. Thesis, Brno University of Technology. Accessed January 23, 2021. http://hdl.handle.net/11012/28908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stránský, Jakub. “Protismykové vlastnosti vozovek: Skid resistance of pavements.” 2019. Web. 23 Jan 2021.

Vancouver:

Stránský J. Protismykové vlastnosti vozovek: Skid resistance of pavements. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11012/28908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stránský J. Protismykové vlastnosti vozovek: Skid resistance of pavements. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/28908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

22. Hamáčková, Martina. Analýza legend map tematických atlasů: Analysis of the keys to the maps of thematic atlases.

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/29460

► This diploma thesis is occupied with analysis of the keys to the maps of Landscape Atlas of the Czech Republic and the Landscape Atlas of… (more)

Subjects/Keywords: Legenda; znak; Atlas krajiny ČR; Atlas krajiny SR.; Key; mark; Landscape Atlas of the CR; Landscape Atlas of the SR.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamáčková, M. (2018). Analýza legend map tematických atlasů: Analysis of the keys to the maps of thematic atlases. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/29460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hamáčková, Martina. “Analýza legend map tematických atlasů: Analysis of the keys to the maps of thematic atlases.” 2018. Thesis, Brno University of Technology. Accessed January 23, 2021. http://hdl.handle.net/11012/29460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hamáčková, Martina. “Analýza legend map tematických atlasů: Analysis of the keys to the maps of thematic atlases.” 2018. Web. 23 Jan 2021.

Vancouver:

Hamáčková M. Analýza legend map tematických atlasů: Analysis of the keys to the maps of thematic atlases. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11012/29460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hamáčková M. Analýza legend map tematických atlasů: Analysis of the keys to the maps of thematic atlases. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/29460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

23. Guo, Cing-Shun. Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas.

Degree: Master, Marine Biotechnology and Resources, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420

► Lenticular mafic volcanic rocks, intercalated with Tertiary sedimentary rocks in the Western foothills of Taiwan, have been altered, and transformed into chloritic clay minerals such… (more)

▼ Lenticular mafic volcanic rocks, intercalated with Tertiary sedimentary rocks in the Western foothills of Taiwan, have been altered, and transformed into chloritic clay minerals such as chlorite, corrensite and smectite. This study, based on the petrography and mineral chemical analysis ,use the trace elements, rare earth elements and isotopes of the volcanic rocks from Neimen and Fangshan areas to investigate the (1) the information of magmatic source and tectonic. (2) relationship of trace elements, rare earth elements and isotope following the degree of alteration between the samples. (3) elements exchange of fluid-rock interaction. (4) distribution of trace elements between the primary and secondary clay minerals. Volcanic rocks of Neimen occur in the sandstone-shale interlayer of Nanchuang formation. In contrast, volcanic rocks in Fangshan River occur as rolling stone. Neimen basalts belong to alkaline basalts, with porphyritic texture. Phenocrysts compose of pyroxene and olivine. Due to alteration processes, olivine phenocrysts are partially replaced by secondary clay minerals which can be subdivided into vein center (VC), vein (V), mica-like(MA) fibrous(F) texture. Augite phenocrysts have not affected by significant alteration. The matrix contains augite, plagioclase, alkali feldspar, titanium magnetite, ilmenite, apatite and clay minerals such as chlorite and smectite, which replace from the matrix. The samples from Fangshan occur as amygdaloidal texture, and are characterized by spilitization features which indicate higher degree of alteration. Its primary minerals have been replaced, remaining the original texture, so it is difficult to identify the type of primary minerals. Amygdules compose of chlorite, calcite, dolomite and quartz. The matrix contains albite, chlorite, corrensite, rutile, apatite, with trace minerals such as chromite, pyrite, chalcopyrite, sphalerite, monazite, halite, and florencite ((Ce, La, Sr)Al3(PO4)2(OH)6). The loss on ignition(L.O.I.) for Neimen and Fangshan samples are 3.20 ~ 4.22 and 4.71 ~ 11.52. Excluding the elements affected by the alteration such as Li, Cs, Rb, Sr and Ti, the trace elements and REE trends in Neimen and Fangshan is closed to ocean island basalt (OIB). According to Zr-Ti-Y and Ha-Th-Ta diagram, the erupted environments of Neimen and Fangshan are intraplate basalts. Sr-Nd isotope system of Neimen is close to fresh samples, but the 87Sr/86Sr of Fangshan is deviated from mantle evolution trend (mantle array) suggesting the reaction fluid may be sea water and have been contaminated by crust endmember when the Igneous stage. LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry) trace element analysis suggests that: both the LREE and incompatible elements of clinopyroxene are depleted. Excluding Ni and Co, olivine doesnât enrich incompatible trace elements. The trends of matrix and whole rock are similar. Li and Cs in clay minerals are apparently enriched. The mica-like clay (MA) has very low trace elements abundance, similar to olivine,… Advisors/Committee Members: Yen-Hong Shau (committee member), Wei-Teh Jiang (chair), Huai-Jen Yang (chair).

Subjects/Keywords: trace elements; Sr-Nd isotopic; hydrothermal alteration; smectite; corrensite; spilite; chlorite

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APA (6^th Edition):

Guo, C. (2014). Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guo, Cing-Shun. “Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas.” 2014. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guo, Cing-Shun. “Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas.” 2014. Web. 23 Jan 2021.

Vancouver:

Guo C. Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guo C. Petrographic and geochemical characteristics of marine basalts from Neimen and Fangshan areas. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-204420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

24. Huang, Jung-heng. Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals.

Degree: Master, Materials Science and Engineering, 2006, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714

► In this work, two (La,Sr)(Al,Ta) O3 single crystals were grown by the conventional Czochralski pulling method by using different rotation rates and pull rates to… (more)

Subjects/Keywords: Sr)(Al; (La; Ta)O3

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APA (6^th Edition):

Huang, J. (2006). Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huang, Jung-heng. “Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals.” 2006. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huang, Jung-heng. “Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals.” 2006. Web. 23 Jan 2021.

Vancouver:

Huang J. Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals. [Internet] [Thesis]. NSYSU; 2006. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huang J. Study on the Czochralski Growth and characterization of (La,Sr)(Al,Ta)O3 single crystals. [Thesis]. NSYSU; 2006. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-135714

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. 野坂, 隆. アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナセラミックスキバンジョウニサクセイシタマイクロハカヘンヨウリョウ (Ba, Sr)TiO3 ハクマクノコウシンライセイカニカンスルケンキュウ.

Degree: Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/5233

Subjects/Keywords: (Ba; Sr)TiO3薄膜

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APA (6^th Edition):

野坂, �. (n.d.). アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナセラミックスキバンジョウニサクセイシタマイクロハカヘンヨウリョウ (Ba, Sr)TiO3 ハクマクノコウシンライセイカニカンスルケンキュウ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/5233

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

野坂, 隆. “アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナセラミックスキバンジョウニサクセイシタマイクロハカヘンヨウリョウ (Ba, Sr)TiO3 ハクマクノコウシンライセイカニカンスルケンキュウ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed January 23, 2021. http://hdl.handle.net/10061/5233.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

野坂, 隆. “アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナセラミックスキバンジョウニサクセイシタマイクロハカヘンヨウリョウ (Ba, Sr)TiO3 ハクマクノコウシンライセイカニカンスルケンキュウ.” Web. 23 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

野坂 �. アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナセラミックスキバンジョウニサクセイシタマイクロハカヘンヨウリョウ (Ba, Sr)TiO3 ハクマクノコウシンライセイカニカンスルケンキュウ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10061/5233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

野坂 �. アルミナセラミックス基板上に作製したマイクロ波可変容量(Ba,Sr)TiO3薄膜の高信頼性化に関する研究 : アルミナセラミックスキバンジョウニサクセイシタマイクロハカヘンヨウリョウ (Ba, Sr)TiO3 ハクマクノコウシンライセイカニカンスルケンキュウ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/5233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Temple University

26. Seiple, Deborah Ann. AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE.

Degree: PhD, 2016, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,387690

►

School Psychology

Executive function (EF) processes are crucial for meeting demands in the classroom. Because of this impact on schooling, it is important to have… (more)

Subjects/Keywords: Educational psychology; Cognitive psychology;

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APA (6^th Edition):

Seiple, D. A. (2016). AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,387690

Chicago Manual of Style (16^th Edition):

Seiple, Deborah Ann. “AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE.” 2016. Doctoral Dissertation, Temple University. Accessed January 23, 2021. http://digital.library.temple.edu/u?/p245801coll10,387690.

MLA Handbook (7^th Edition):

Seiple, Deborah Ann. “AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE.” 2016. Web. 23 Jan 2021.

Vancouver:

Seiple DA. AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2021 Jan 23]. Available from: http://digital.library.temple.edu/u?/p245801coll10,387690.

Council of Science Editors:

Seiple DA. AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,387690

Cornell University

27. Meek, Katherine. 87Sr/86Sr, Ca/Sr, And Ge/Si Ratios As Tracers Of Solute Sources At A Temperate Forested, Shale Catchment In Central Pennsylvania.

Degree: M.S., Geological Sciences, Geological Sciences, 2015, Cornell University

URL: http://hdl.handle.net/1813/39367

► Weathering processes, governed by dissolution kinetics as well as by the rates and directions of flowing water, are important mechanisms through which solutes are added… (more)

▼ Weathering processes, governed by dissolution kinetics as well as by the rates and directions of flowing water, are important mechanisms through which solutes are added to watersheds. Flow pathways control the fate and transport of incoming precipitation inputs and consequently, influence water-rock interactions, degrees of weathering, and distributions of solutes in watersheds. Furthermore, plants directly impact the availability of solutes in soil and porewater reservoirs through infiltration, evapotranspiration, decomposition, and preferential discrimination processes. To this end, strontium isotope ratios (87Sr/86Sr), elemental ratios (Ca/Sr, Ge/Si), and elemental concentrations are used to document sources of solutes at a temperate forested, shale catchment in central Pennsylvania. Spatio-temporal patterns are assessed and inferences are developed using empirical data supplemented by observations on mineral weathering, proposed preferential flow pathways, and plant transport mechanisms at the catchment. In particular, this study entails a comprehensive analysis of calcium, strontium, silicon, and germanium sources in plant leaves and sap waters and in streamwaters, groundwaters, soil porewaters, exchangeable soils, and bedrock in order to investigate hydrological (preferential flow pathways), topographical (hillslope geometry), biological (evapotranspiration, decomposition, and plant preferential discrimination), and mineralogical (dominant weathering inputs) controls on their availability and distribution at the watershed. For soils and soil porewaters, spatial patterns in chemistry largely reflect lateral and vertical preferential flow processes which influence solute residence times and the transfer of weathering products either in the soil profile or to downslope locations. As such, topographic gradient plays a circumstantial role in lateral subsurface transport processes downslope. Furthermore, biological activities including plant preferential discrimination, decomposition, and evapotranspiration impact near surface spatial patterns and in particular, temporal patterns in soil and soil porewater chemistry. Although solutes in soils and soil porewaters at ridge top and mid slope locations are largely derived from silicate mineral weathering, influences of carbonate dissolution processes on calcium and strontium are rather significant at valley floor locations where recharge of carbonate affected groundwaters is probable. Strontium isotope ratios in soil reservoirs correspond closely to those in leaves which is consistent with the rapid homogenization of solutes added from weathering and atmospheric sources by biological nutrient cycling processes. Controls on spatio-temporal patterns in leaf and sap water chemistry are predictably similar to those observed for soils and soil porewaters, from which these reservoir components are largely acquiring solutes. However, plant transport mechanisms through the xylem are also important where apoplastic passive transport is suggested for calcium and strontium, while… Advisors/Committee Members: Derry, Louis A. (chair), Cathles, Lawrence M (committee member).

Subjects/Keywords: 87Sr/86Sr; Ca/Sr; Ge/Si; Multi-tracer approach

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meek, K. (2015). 87Sr/86Sr, Ca/Sr, And Ge/Si Ratios As Tracers Of Solute Sources At A Temperate Forested, Shale Catchment In Central Pennsylvania. (Masters Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/39367

Chicago Manual of Style (16^th Edition):

Meek, Katherine. “87Sr/86Sr, Ca/Sr, And Ge/Si Ratios As Tracers Of Solute Sources At A Temperate Forested, Shale Catchment In Central Pennsylvania.” 2015. Masters Thesis, Cornell University. Accessed January 23, 2021. http://hdl.handle.net/1813/39367.

MLA Handbook (7^th Edition):

Meek, Katherine. “87Sr/86Sr, Ca/Sr, And Ge/Si Ratios As Tracers Of Solute Sources At A Temperate Forested, Shale Catchment In Central Pennsylvania.” 2015. Web. 23 Jan 2021.

Vancouver:

Meek K. 87Sr/86Sr, Ca/Sr, And Ge/Si Ratios As Tracers Of Solute Sources At A Temperate Forested, Shale Catchment In Central Pennsylvania. [Internet] [Masters thesis]. Cornell University; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1813/39367.

Council of Science Editors:

Meek K. 87Sr/86Sr, Ca/Sr, And Ge/Si Ratios As Tracers Of Solute Sources At A Temperate Forested, Shale Catchment In Central Pennsylvania. [Masters Thesis]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/39367

Université du Québec à Montréal

28. Martineau, Corine. Rôle du récepteur scavenger de classe B, type I (SR-BI) dans la régulation du métabolisme osseux.

Degree: 2014, Université du Québec à Montréal

URL: http://archipel.uqam.ca/7185/1/D2742.pdf

► Le récepteur scavenger de classe B, type I (SR-BI) est un récepteur de lipoprotéines de haute densité (HDL) participant au transport inverse du cholestérol (RCT),… (more)

▼ Le récepteur scavenger de classe B, type I (SR-BI) est un récepteur de lipoprotéines de haute densité (HDL) participant au transport inverse du cholestérol (RCT), un processus l'éliminant par captation sélective à partir des HDL dans le foie. Vu ce rôle, l'ablation du gène du SR-BI (Scarb1) réduit les niveaux de RCT et prédispose certains modèles murins à l'athérosclérose. Des études associent l'incidence de cette pathologie à celle de l'ostéoporose, soit un plus haut risque de fractures dû à une faible masse osseuse. Notre équipe a récemment démontré l'expression du SR-BI dans les ostéoblastes (OB), les cellules responsables de la formation osseuse. Ainsi, cette thèse explore l'impact du SR-BI sur la physiologie osseuse. Le remodelage osseux inclut la formation effectuée par les OB, d'origine mésenchymale, et la résorption faite par les ostéoclastes (OC) d'origine hématopoïétique. Un déséquilibre entre formation et résorption cause des désordres tels que l'ostéoporose. Afin de définir le rôle du SR-BI dans l'os, nous avons étudié l'impact de son absence sur le métabolisme osseux chez la souris. Le premier volet de cette thèse explore le phénotype osseux de souris déficientes pour Scarb1; celles-ci présentent une masse et une formation osseuses accrues dans la portion trabéculaire des fémurs. Le potentiel prolifératif et ostéogénique des cellules stromales mésenchymales (MSC) mutantes est rehaussé, un phénotype associé à la sous-expression de cavéoline-1 (Cav1) et la surexpression d'ostérix (Sp7). Les niveaux d'hormone adrénocorticotropique (ACTH) circulante sont constitutivement élevés chez les souris mutantes, dû à l'absence d'induction de sécrétion des glucocorticoïdes (GC) en situation de stress. La déficience pour Scarb1 augmente donc la masse osseuse potentiellement selon deux mécanismes : par des voies systémiques associées à des taux élevés d'ACTH, et par des altérations des fonctions ostéoblastiques des MSC. Étant donné les différences phénotypiques osseuses entre mâles et femelles, une exploration de l'impact de la déficience pour Scarb1 sur le dimorphisme sexuel squelettique constitue le second volet de cette étude. Seules les femelles déficientes pour Scarb1 affichent une masse vertébrale osseuse augmentée; des analyses plasmatiques révèlent des anomalies de l'axe GC/ACTH similaires à celles des mâles. Par ailleurs, aucune différence n'est mesurée quant aux niveaux plasmatiques d'estradiol (E2) entre les souris mutantes et de type sauvage, excluant ces deux axes hormonaux comme principales causes des altérations des vertèbres particulières aux femelles déficientes pour Scarb1. Cependant, des niveaux plasmatiques de leptine constitutivement élevés chez les femelles mutantes, accompagnés d'une expression accrue de leptine par les adipocytes, expliquent potentiellement les différences liées au genre. Les MSC issues de souris femelles déficientes pour Scarb1 présentent une altération de l'expression de marqueurs ostéogéniques, tout comme les cellules des mâles. Ces MSC répondent à la leptine et à l'ACTH de…

Subjects/Keywords: Os. Métabolisme. Régulation; Os. Physiologie; Cellules osseuses; Récepteurs éboueurs; SR-BI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martineau, C. (2014). Rôle du récepteur scavenger de classe B, type I (SR-BI) dans la régulation du métabolisme osseux. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/7185/1/D2742.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martineau, Corine. “Rôle du récepteur scavenger de classe B, type I (SR-BI) dans la régulation du métabolisme osseux.” 2014. Thesis, Université du Québec à Montréal. Accessed January 23, 2021. http://archipel.uqam.ca/7185/1/D2742.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martineau, Corine. “Rôle du récepteur scavenger de classe B, type I (SR-BI) dans la régulation du métabolisme osseux.” 2014. Web. 23 Jan 2021.

Vancouver:

Martineau C. Rôle du récepteur scavenger de classe B, type I (SR-BI) dans la régulation du métabolisme osseux. [Internet] [Thesis]. Université du Québec à Montréal; 2014. [cited 2021 Jan 23]. Available from: http://archipel.uqam.ca/7185/1/D2742.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martineau C. Rôle du récepteur scavenger de classe B, type I (SR-BI) dans la régulation du métabolisme osseux. [Thesis]. Université du Québec à Montréal; 2014. Available from: http://archipel.uqam.ca/7185/1/D2742.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Đokić Bojan. Srpska javnost o međunacionalnim odnosima u Socijalističkoj Autonomnoj Pokrajini Kosovo 1981-1989.

Degree: 2019, University of Novi Sad

URL: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija155989491938584.pdf?controlNumber=(BISIS)110741&fileName=155989491938584.pdf&id=12955&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=110741&source=OATD&language=en

► Cilj doktorske disertacije je bio da se na osnovu srpske dnevne i nedeljne štampe istraži odnos srpske javnosti prema položaju srpskog stanovništva u SAP… (more)

▼ Cilj doktorske disertacije je bio da se na osnovu srpske dnevne i nedeljne štampe istraži odnos srpske javnosti prema položaju srpskog stanovništva u SAP Kosovu u periodu od proleća 1981. do proleća 1989. godine. U disertaciji smo pažnju poklonili analizi međunacionalnih napetosti i stavovima političke, intelektualne i crkvene javnosti. Analizirali smo delovanje i ulogu političke elite, Srpske pravoslavne crkve i srpske stvaralačke inteligencije. Na osnovu njihovog delovanja i javnog stava izvukli smo sledeće zaključke: -Međunacionalni odnosi su narušeni izbijanjem velikih nereda albanskog stanovništva marta i aprila 1981. godine; -Posle nereda u SAP Kosovu 1981. godine, u srpski javni diskurs ušla su dva pojma: navodni „genocid” koji se vršio nad srpskim stanovništvom u SAP Kosovu i prinudno iseljavanje (etničko čišćenje) srpskog stanovništva iz SAP Kosova; -Oba pojma su ostala uklesana u srpsko javno mnjenje tokom proučavanog perioda kao nepromenjiva istina; oba pojma su proizašla iz teškog položaja odnosno ugroženosti srpskog stanovništva u SAP Kosovu, ali i iz političkih razloga; oba pojma su od samog početka izazivala različite reakcije u srpskoj javnosti i uticala na buđenje nacionalnih emocija; oba pojma su tokom 80-ih godina XX veka ostala u medijsko-propagandnoj sferi; -Položaj srpskog stanovništva u SAP Kosovu u proučavanom periodu bio je težak, što je vidljivo po podatku da je najveći broj krivičnih i prekršajnih dela između lica različitih nacionalnosti izvršen na štetu srpskog i crnogorskog naroda. Veliki broj krivičnih i prekršajnih dela koji su izvršeni nad srpskim i crnogorskim stanovništvom u SAP Kosovu doprineo je lakšoj politizaciji kriminala u srpskoj javnosti. Srpska javna glasila vršila su politizaciju i najmanjeg međunacionalnog ekscesa, pa su zato međunacionalni odnosi u SAP Kosovu posmatrani uglavnom kroz ekscesne situacije. -Težak položaj srpskog stanovništva u SAP Kosovu omogućilo je stvaranje njegove viktimizacije što se masovno koristilo u istupanju srpske političke, crkvene i intelektualne elite. Viktimizacija srpskog stanovništva od „albanskog neprijatelja” bio je glavni narativ u srpskim javnim glasilima tokom 80-ih godina XX veka. -Medijski konstruisani narativ viktimizacije srpskog stanovništva imao je političku pozadinu, pa je koncept viktimizacije srpske nacije bio stalno prisutan u srpskim sredstvima javnog informisanja. -Kao primarni problem u međunacionalnim odnosima u SAP Kosovu isticano je prinudno iseljavanje srpskog stanovništva. Od 1981. godine, iseljavanje je postalo… Advisors/Committee Members: Bjelica Slobodan, Simunovic-Beslin Biljana, Radojević Mira, Barovic Vladimir.

Subjects/Keywords: Srpska javnost; međunacionalni odnosi; SAPKosovo; SR Srbija; SFRJ

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bojan, �. (2019). Srpska javnost o međunacionalnim odnosima u Socijalističkoj Autonomnoj Pokrajini Kosovo 1981-1989. (Thesis). University of Novi Sad. Retrieved from https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija155989491938584.pdf?controlNumber=(BISIS)110741&fileName=155989491938584.pdf&id=12955&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=110741&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bojan, Đokić. “Srpska javnost o međunacionalnim odnosima u Socijalističkoj Autonomnoj Pokrajini Kosovo 1981-1989.” 2019. Thesis, University of Novi Sad. Accessed January 23, 2021. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija155989491938584.pdf?controlNumber=(BISIS)110741&fileName=155989491938584.pdf&id=12955&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=110741&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bojan, Đokić. “Srpska javnost o međunacionalnim odnosima u Socijalističkoj Autonomnoj Pokrajini Kosovo 1981-1989.” 2019. Web. 23 Jan 2021.

Vancouver:

Bojan �. Srpska javnost o međunacionalnim odnosima u Socijalističkoj Autonomnoj Pokrajini Kosovo 1981-1989. [Internet] [Thesis]. University of Novi Sad; 2019. [cited 2021 Jan 23]. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija155989491938584.pdf?controlNumber=(BISIS)110741&fileName=155989491938584.pdf&id=12955&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=110741&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bojan �. Srpska javnost o međunacionalnim odnosima u Socijalističkoj Autonomnoj Pokrajini Kosovo 1981-1989. [Thesis]. University of Novi Sad; 2019. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija155989491938584.pdf?controlNumber=(BISIS)110741&fileName=155989491938584.pdf&id=12955&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=110741&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

30. Myburgh, Travis Louis. On-line fault detection and end-of-batch quality prediction for batch processes incorporating on-line synchronisation and phase identification.

Degree: MEng, Process Engineering, 2016, Stellenbosch University

URL: http://hdl.handle.net/10019.1/100263

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ENGLISH ABSTRACT: Batch processes are transient processes, which present a unique monitoring challenge. Whereas the expected output variables of a continuous process centre on specific… (more)

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ENGLISH ABSTRACT: Batch processes are transient processes, which present a unique monitoring challenge. Whereas the expected output variables of a continuous process centre on specific target values that represent some steady state, batch process variables inherently change from an initial state to a final state. Abnormal events, or faults, that occur in batch processes can be identified with an appropriate monitoring scheme. Bilinear statistical modelling based on latent methods, such as Partial Least Squares (PLS), have been shown by Nomikos and MacGregor (1995) to be an effective way to detect faults and predict the end-of-batch quality. A batch process monitoring toolbox has previously been developed, which supports off-line modelling and monitoring of batch processes. The limitation of off-line monitoring is that product end-of-batch quality and fault detection can only be assessed once the batch has been completed. On-line fault detection and end-of-batch quality prediction in near-real time endeavors to address this limitation. The aim of this project was to implement an on-line monitoring platform which can detect faults and predict end-of-batch quality in a timely manner. Synchronization of the batch trajectories is a computationally expensive step in off-line monitoring, and the ability of the on-line platform to produce computationally efficient results comparable to off-line synchronization was assessed. The Relaxed Greedy Time Warping (RGTW) approach (González-Martínez et al., 2011) was used to synchronise the trajectories in an on-line fashion. The approach was able to produce comparable results in a computationally efficient way, but some inaccuracies were observed during flat regions of the batch trajectories. The nature of phases for accurate modelling of batch data was also investigated. Models were built for batch data partitioned in three ways: no partitions, partitions based on known process stages and partitions based on linear correlation structure between the variables and the end-of-batch quality prediction accuracy was compared. The multiphase partial least squares (MPPLS) algorithm (Camacho, et al., 2007) was used to find the changes in linear correlation among the process variables and partition the data accordingly. Partitioning the data using the MPPLS algorithm showed comparable or statistically significant reductions in the overall end-of-batch prediction error compared with the other two data partitioning methods. The models were applied on-line to two case studies using the on-line monitoring platform and the fault detection and end-of-batch quality prediction accuracy were assessed for the three data partioning methods. The end-of-batch predictions made using the MPPLS algorithm provided the most accurate end-of-batch predictions. Improper on-line synchronisation caused false alarms in certain areas of the batch trajectory, but faults were detected with relative accuracy.

AFRIKAANSE OPSOMMING: Enkelladingprosesse is oorgangsprosesse, wat ’n unieke…

Advisors/Committee Members: Auret, Lidia, Burger, A. J., Stellenbosch University. Faculty of Engineering. Dept. of Process Engineering..

Subjects/Keywords: Fault location (Engineering); UCTD; Fault-tolerant computing; SR (Computer program language)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Myburgh, T. L. (2016). On-line fault detection and end-of-batch quality prediction for batch processes incorporating on-line synchronisation and phase identification. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/100263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Myburgh, Travis Louis. “On-line fault detection and end-of-batch quality prediction for batch processes incorporating on-line synchronisation and phase identification.” 2016. Thesis, Stellenbosch University. Accessed January 23, 2021. http://hdl.handle.net/10019.1/100263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Myburgh, Travis Louis. “On-line fault detection and end-of-batch quality prediction for batch processes incorporating on-line synchronisation and phase identification.” 2016. Web. 23 Jan 2021.

Vancouver:

Myburgh TL. On-line fault detection and end-of-batch quality prediction for batch processes incorporating on-line synchronisation and phase identification. [Internet] [Thesis]. Stellenbosch University; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10019.1/100263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Myburgh TL. On-line fault detection and end-of-batch quality prediction for batch processes incorporating on-line synchronisation and phase identification. [Thesis]. Stellenbosch University; 2016. Available from: http://hdl.handle.net/10019.1/100263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations