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1. Kolotoura, Athina. Μελέτη της μακροχρόνιας ενδονωτιαίας χορήγησης οποιειδών ή/και μπακλοφαΐνης σε ασθενείς με χρόνιο πόνο ή/και σπαστικότητα μέσω πλήρως εφυτεύσιμων συστημάτων συνεχούς ροής: πλεονεκτήματα και προτεινόμενα δοσολογικά σχήματα και τεχνικές.

Degree: 2013, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

In this thesis, we tried to study and determine the impact and long-term action methodologies intrathecal drug infusion using a special implanted pump in patients with symptoms of intense pain and severe spasticity. The study involved 80 patients, only patients in the Pain Management Unit of the General Hospital of Eleusis "Thria-sio", clinical or other departments of the same hospital or patients who have been re-ferred from other centers in the region that meet the selection criteria.The monitoring of the patients took place at predetermined time intervals (fol-low-up) (year "0" by recording the initial measurements at 15 days, 30 days and once monthly after the placement of the pump and for a period of 15 months) using the rel-evant scales (VAS, Ashworth and ACPA). In this study became statistical significant relationship between dose of morphine and the dose of baclofen on the quality of life (Ρ=0,028 and Ρ =0,014, respectively) on the 15th day of clinical monitoring.Our results show a long-lasting relief from chronic pain, as measured by the scale VAS, but an improvement of quality of life (fifteen months of the intervention), based on ACPA scale.However, the beneficial analgesic effect accompanied by a corresponding in-crease of the dose of all drugs administered. Specifically, all patients showed a reduc-tion in pain and spasticity, without any adverse pharmacological actions. The lack of adverse side effects attributable to the close monitoring of patients and gradual titra-tion to the needs and satisfaction with pain and spasticity.The results demonstrate the safety and effectiveness of intrathecal morphine, fen-tanyl, clonidine and/or baclofen for the treatment of refractory chronic persistent pain and severe spasticity.

Subjects/Keywords: Εμφυτεύσιμα συστήματα ενδορραχιαίας έγχυσης; Ενδορραχιαία χορήγηση; Χρόνιος πόνος; Σπαστικότητα; Οπιοειδή; Μπακλοφαΐνη; Implantable drug delivery systems / idds; Spinal infusion; Chronic pain; Severe spasticity; Opioids; Baclofen

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kolotoura, A. (2013). Μελέτη της μακροχρόνιας ενδονωτιαίας χορήγησης οποιειδών ή/και μπακλοφαΐνης σε ασθενείς με χρόνιο πόνο ή/και σπαστικότητα μέσω πλήρως εφυτεύσιμων συστημάτων συνεχούς ροής: πλεονεκτήματα και προτεινόμενα δοσολογικά σχήματα και τεχνικές. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/41460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kolotoura, Athina. “Μελέτη της μακροχρόνιας ενδονωτιαίας χορήγησης οποιειδών ή/και μπακλοφαΐνης σε ασθενείς με χρόνιο πόνο ή/και σπαστικότητα μέσω πλήρως εφυτεύσιμων συστημάτων συνεχούς ροής: πλεονεκτήματα και προτεινόμενα δοσολογικά σχήματα και τεχνικές.” 2013. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed July 21, 2019. http://hdl.handle.net/10442/hedi/41460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kolotoura, Athina. “Μελέτη της μακροχρόνιας ενδονωτιαίας χορήγησης οποιειδών ή/και μπακλοφαΐνης σε ασθενείς με χρόνιο πόνο ή/και σπαστικότητα μέσω πλήρως εφυτεύσιμων συστημάτων συνεχούς ροής: πλεονεκτήματα και προτεινόμενα δοσολογικά σχήματα και τεχνικές.” 2013. Web. 21 Jul 2019.

Vancouver:

Kolotoura A. Μελέτη της μακροχρόνιας ενδονωτιαίας χορήγησης οποιειδών ή/και μπακλοφαΐνης σε ασθενείς με χρόνιο πόνο ή/και σπαστικότητα μέσω πλήρως εφυτεύσιμων συστημάτων συνεχούς ροής: πλεονεκτήματα και προτεινόμενα δοσολογικά σχήματα και τεχνικές. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10442/hedi/41460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kolotoura A. Μελέτη της μακροχρόνιας ενδονωτιαίας χορήγησης οποιειδών ή/και μπακλοφαΐνης σε ασθενείς με χρόνιο πόνο ή/και σπαστικότητα μέσω πλήρως εφυτεύσιμων συστημάτων συνεχούς ροής: πλεονεκτήματα και προτεινόμενα δοσολογικά σχήματα και τεχνικές. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. Available from: http://hdl.handle.net/10442/hedi/41460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Florida

2. Chen, Xiaoming. Convection-Enhanced Delivery of Macromolecules into Nervous Tissue Computational Modeling, MR Imaging, and Experiments.

Degree: PhD, Mechanical Engineering - Mechanical and Aerospace Engineering, 2008, University of Florida

Convection-enhanced delivery (CED) is a local drug delivery technique which directly infuses drug into the parenchyma of nervous tissue via a cannula. CED provides a promising drug delivery method for treating diseases of the nervous system such as brain tumors, spinal cord injury, and Parkinson?s disease since it circumvents the blood brain barrier, provides more accurate targeting, and reduces the potential of systemic toxicity. CED enhances drug transport into nervous tissue by introducing convectional transport in addition to diffusional transport. This is particularly important for therapy where a large drug distribution volume on the order of centimeters is necessary. Drugs delivered to undesired regions may cause side effects or damage healthy tissues, especially for tumor therapy where many therapeutic agents are toxic. Therapeutic doses should also be in an appropriate range since high doses may be toxic while low doses may result in ineffectual treatment. Concentration distribution of therapeutic agents after infusion is significantly related to CED protocol such as cannula shape and size, infusion site and rate, and infusate concentration. Thus, the CED protocol needs to be well designed. To improve CED protocol design, previous studies have used mathematical models to investigate the mechanics of infusion. These studies provided limited prediction ability. MR imaging methods have also been used to monitor drug distribution during CED. These imaging studies provided limited quantification capacity. Additional prediction tools and imaging techniques need to be developed for potential application in clinical CED protocol optimization and planning. The purpose of this dissertation is to provide fundamental methodologies, in computational modeling and MR imaging techniques, for CED to improve the CED technique and application. First, a biphasic finite element (FE) modeling of CED into nervous tissue was developed. The FE-based model solved for both the fluid flow and macromolecular transport. The model also accounted for deformation-dependent hydraulic permeability, which is difficult to account for using analytical methods. Infusion from a constant pressure source was modeled. In addition, parametric analysis was conducted to determine the sensitivity of macromolecular distribution to changes in tissue properties and infusion parameters. The developed FE model provides a platform upon which anisotropic transport and realistic anatomical boundaries may be modeled in the future. Second, experimental micro-indentation to measure biphasic properties, i.e., Young's modulus and hydraulic permeability, was investigated. Characterization of these tissue properties is necessary for further development of computational transport models. Previous property measurements using micro-indentation are limited to specific indentation configurations. This dissertation used a biphasic FE model for micro-indentation. Micro-indentation using a spherical impermeable indenter on a thin hydrogel contact lens was conducted.… Advisors/Committee Members: Sarntinoranont, Malisa (committee chair), Chung, Jacob N. (committee member), Tran-Son-Tay, Roger (committee member), Mareci, Thomas H. (committee member).

Subjects/Keywords: Hydraulics; Hydrogels; Imaging; Nerve tissue; Nerves; Rats; Signals; Solutes; Spinal cord; Velocity; albumin, biotransport, biphasic, ced, contrast, csf, delivery, edema, indentation, infusion, mri, poroelastic, relaxivity, sciatic, spinal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chen, X. (2008). Convection-Enhanced Delivery of Macromolecules into Nervous Tissue Computational Modeling, MR Imaging, and Experiments. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0022443

Chicago Manual of Style (16th Edition):

Chen, Xiaoming. “Convection-Enhanced Delivery of Macromolecules into Nervous Tissue Computational Modeling, MR Imaging, and Experiments.” 2008. Doctoral Dissertation, University of Florida. Accessed July 21, 2019. http://ufdc.ufl.edu/UFE0022443.

MLA Handbook (7th Edition):

Chen, Xiaoming. “Convection-Enhanced Delivery of Macromolecules into Nervous Tissue Computational Modeling, MR Imaging, and Experiments.” 2008. Web. 21 Jul 2019.

Vancouver:

Chen X. Convection-Enhanced Delivery of Macromolecules into Nervous Tissue Computational Modeling, MR Imaging, and Experiments. [Internet] [Doctoral dissertation]. University of Florida; 2008. [cited 2019 Jul 21]. Available from: http://ufdc.ufl.edu/UFE0022443.

Council of Science Editors:

Chen X. Convection-Enhanced Delivery of Macromolecules into Nervous Tissue Computational Modeling, MR Imaging, and Experiments. [Doctoral Dissertation]. University of Florida; 2008. Available from: http://ufdc.ufl.edu/UFE0022443

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