subject:(Spinal cord injury)

University of Otago

1. Conway, Trudi May. Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/626

► Outdoor recreation programmes (ORP) have the potential to assist in the rehabilitation and community reintegration process for individuals recovering from spinal cord injury (SCI). Previous… (more)

▼ Outdoor recreation programmes (ORP) have the potential to assist in the rehabilitation and community reintegration process for individuals recovering from spinal cord injury (SCI). Previous evidence provides support for the use of meaningful recreation, leisure activities, and physical exercise in the maintenance of health and development of self-efficacy, peer support and socialisation, thus assisting individuals with SCI to reintegrate back into their communities. However, there are few studies that evaluate the lived experience of individuals with SCI participating in ORPs and the potential benefits of these programmes. A qualitative study using constructivist grounded theory was chosen to gain an understanding of the personal experiences of individuals with SCI who attend these programmes and the influence the programme had on their lives. Eight individuals with SCI who attended an ORP were interviewed twice using semi-structured in-depth interviews. The first interview occurred at the beginning of the ORP and the second interview took place approximately three months following completion of the ORP. Interview data were supplemented by field notes from observation of the participants on the ORPs. From the data collected a model was developed to reflect the key themes and concepts that represented the participants’ experiences and perceptions of attending an ORP. Overall, the participants’ experience was positive. The model depicted three stages in the overall gains made from attending an ORP. These included: immediate benefits, secondary consequences and real life consequences. Three key themes emerged as being the immediate benefits: i) ‘Gaining knowledge and skills’, ii) ‘Learning from peers’ and iii) ‘Pushing boundaries’. These immediate benefits contributed to the secondary consequences: iv) ‘Building confidence’ and v) ‘Self discovery’. The secondary consequences enabled the participant to vi) ‘Get out there’ and participate more following completion of the programme, with increased options in life and therefore to vii) ‘Live and reclaim life’. These latter themes are considered to reflect the real life consequences of attending the ORP. The overall substantive theory that emerged from this study was how attendance at the ORP contributed to the participants with SCI reclaiming and living their lives. The participants indicated they had benefited physically and psychologically from attendance, with the combination of these gains enabling them to engage more actively in social, recreational and vocational pursuits. This resulted in each individual beginning to reclaim or succeeding in reclaiming and living their lives. The participants felt that they now had opportunities and options in their lives. Clinically the data collected in this study and the theory that emerged from the data will enable funders and providers of rehabilitation services to consider ORP as a beneficial adjunct to the rehabilitation and reintegration of individuals with SCI, especially for those individuals who have struggled to… Advisors/Committee Members: Levack, William (advisor).

Subjects/Keywords: Spinal Cord Injury; Outdoor recreation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Conway, T. M. (2011). Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/626

Chicago Manual of Style (16^th Edition):

Conway, Trudi May. “Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes .” 2011. Masters Thesis, University of Otago. Accessed February 25, 2020. http://hdl.handle.net/10523/626.

MLA Handbook (7^th Edition):

Conway, Trudi May. “Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes .” 2011. Web. 25 Feb 2020.

Vancouver:

Conway TM. Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes . [Internet] [Masters thesis]. University of Otago; 2011. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10523/626.

Council of Science Editors:

Conway TM. Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes . [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/626

University of Ottawa

2. Li, Ruifu. A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair .

Degree: 2014, University of Ottawa

URL: http://hdl.handle.net/10393/31410

► Spinal Cord Injury (SCI) often causes cell death, demyelination, axonal degeneration and cavitation, resulting in functional motor and sensory loss below the site of injury.… (more)

Subjects/Keywords: Hyaluronic acid; Spinal cord injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, R. (2014). A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/31410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Ruifu. “A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair .” 2014. Thesis, University of Ottawa. Accessed February 25, 2020. http://hdl.handle.net/10393/31410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Ruifu. “A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair .” 2014. Web. 25 Feb 2020.

Vancouver:

Li R. A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair . [Internet] [Thesis]. University of Ottawa; 2014. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10393/31410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li R. A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair . [Thesis]. University of Ottawa; 2014. Available from: http://hdl.handle.net/10393/31410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

3. Conroy, James Peter. Starting again: making art after a spinal cord injury .

Degree: 2014, University of Sydney

URL: http://hdl.handle.net/2123/13359

► This thesis explores how one's art practice changes after suffering a spinal cord injury. Throughout this MFA I document how my art practice changed after… (more)

Subjects/Keywords: Painting; Spinal cord injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Conroy, J. P. (2014). Starting again: making art after a spinal cord injury . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/13359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Conroy, James Peter. “Starting again: making art after a spinal cord injury .” 2014. Thesis, University of Sydney. Accessed February 25, 2020. http://hdl.handle.net/2123/13359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Conroy, James Peter. “Starting again: making art after a spinal cord injury .” 2014. Web. 25 Feb 2020.

Vancouver:

Conroy JP. Starting again: making art after a spinal cord injury . [Internet] [Thesis]. University of Sydney; 2014. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/2123/13359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Conroy JP. Starting again: making art after a spinal cord injury . [Thesis]. University of Sydney; 2014. Available from: http://hdl.handle.net/2123/13359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

4. van Wyk, Vania. Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa .

Degree: 2018, University of the Western Cape

URL: http://hdl.handle.net/11394/6873

► The distressing event of Spinal Cord Injury (SCI) leads to complete or incomplete injury, and results in many complications such as such as neurogenic shock,… (more)

Subjects/Keywords: Spinal cord injury; Trauma; Participation; Traumatic spinal cord injury; Rehabilitation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van Wyk, V. (2018). Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

van Wyk, Vania. “Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa .” 2018. Thesis, University of the Western Cape. Accessed February 25, 2020. http://hdl.handle.net/11394/6873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

van Wyk, Vania. “Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa .” 2018. Web. 25 Feb 2020.

Vancouver:

van Wyk V. Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa . [Internet] [Thesis]. University of the Western Cape; 2018. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/11394/6873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

van Wyk V. Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa . [Thesis]. University of the Western Cape; 2018. Available from: http://hdl.handle.net/11394/6873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

5. Meisner, Jason George. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.

Degree: PhD, Department of Anatomy & Neurobiolgy with Neuroscience, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/14411

► Neuropathic pain is a significant and frequent outcome of spinal cord injury (SCI), and is often refractory to treatment. A better understanding of the pathological… (more)

▼ Neuropathic pain is a significant and frequent outcome of spinal cord injury (SCI), and is often refractory to treatment. A better understanding of the pathological processes following injury that contribute to the development of neuropathic pain will aid the search for novel therapeutics. In the second chapter of this thesis a murine model of post-SCI below-lesion neuropathic pain was utilized to investigate changes in GABAergic tone. The gad1:GFP transgenic mouse line allowed the study of a subpopulation of GFPlabeled GABAergic neurons under control of the GABA synthesizing glutamate decarboxylase enzyme. SCI was observed to result in a loss of GABAergic neurons, and secondary markers of GABAergic tone supported this observation. This finding suggests that GABAergic interneuron cell death accounts for the decreased GABAergic tone previously reported post-SCI. In the third chapter of this thesis it was attempted to prevent the death of GABAergic neurons post-SCI using a transgenic mouse line expressing increased levels of the X-linked inhibitor of apoptosis (XIAP) under the ubiquitin C promoter. No differences were observed between ubXIAP and wildtype mice, indicating that increased expression of XIAP is not sufficient to prevent the development of neuropathic pain post- SCI. The fourth chapter of this thesis attempted to prevent the development of neuropathic pain through a novel treatment schedule of the drug pregabalin. Pregabalin administered shortly after SCI prevented the development of neuropathic pain. Pregabalin initiated 1 week post-SCI had no effect. Early pregabalin treatment did not appear to dramatically alter glial activation, or expression of the pregabalin receptor, but we observed changes in markers associated with synaptic plasticity. My findings build upon our knowledge of the mechanisms underlying post-SCI below-lesion neuropathic pain, and suggest new avenues of research, such as the uses of preemptive treatment with pregabalin, that offer promise for translation to clinical use. Advisors/Committee Members: Claire Hulsebosch (external-examiner), Kazue Semba (graduate-coordinator), William Baldridge (thesis-reader), Ronald Leslie (thesis-reader), Stefan Kruger (thesis-reader), Daniel Marsh (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: SPINAL CORD INJURY; PAIN; GABA; PREGABALIN

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meisner, J. G. (2012). POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14411

Chicago Manual of Style (16^th Edition):

Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Doctoral Dissertation, Dalhousie University. Accessed February 25, 2020. http://hdl.handle.net/10222/14411.

MLA Handbook (7^th Edition):

Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Web. 25 Feb 2020.

Vancouver:

Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Internet] [Doctoral dissertation]. Dalhousie University; 2012. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10222/14411.

Council of Science Editors:

Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Doctoral Dissertation]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/14411

University of Georgia

6. Bickel, Christopher Scott. Factors that influence muscle torque after spinal cord injury.

Degree: PhD, Exercise Science, 2002, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/bickel_christopher_s_200212_phd

► Electromyostimulation (EMS) is often used in rehabilitation settings to evoke contractions in paralyzed muscle. Unfortunately, EMS inherently causes greater fatigue than voluntary activation. Muscles that… (more)

▼ Electromyostimulation (EMS) is often used in rehabilitation settings to evoke contractions in paralyzed muscle. Unfortunately, EMS inherently causes greater fatigue than voluntary activation. Muscles that are unloaded are susceptible to contraction-induced muscle injury. Therefore, the purpose of this study is to investigate factors that can influence torque production, such as variable-frequency train stimulation and contraction-induced muscle injury, in patients with spinal cord injury (SCI). In the first study, able-bodied (AB) and SCI subjects had their Muscle Quadriceps Femoris (m. QF) stimulated with constant-frequency trains (CFT) (six 200-ms square wave pulses separated by 70-ms) or variable-frequency trains (VFT) (identical to CFT except initial interpulse interval separated by 5 ms). After a fatigue protocol that consisted of 180 contractions (50% duty cycle), the isometric peak torque was reduced by 44%, 56%, and 67% in AB, acute SCI, and chronic SCI groups, respectively. The VFTs enhanced the torque-time integral by 18% compared to CFT in AB subjects and VFTs had a much smaller effect in SCI patients. The second study utilized magnetic resonance (MR) images and EMS to evaluate the susceptibility of paralyzed muscle to contraction-induced injury. MR images were taken of the m. QF prior to, immediately post, and three days post EMS, which consisted of 80 isometric contractions. The relative muscle cross-sectional area (CSA) activated and injured was determined by the number of pixels with an elevated T2 signal. EMS resulted in a decline of peak torque by 66% and 37% for SCI and AB subjects, respectively. EMS activated 66% of AB muscle QF of which 2% of the activated muscle was injured. In contrast, the SCI group had 25% of their activated muscle injured due to EMS. These results indicate that VFT stimulation does not appear to augment torque in SCI patients to the same extent as AB subjects. They also suggest that electrically-elicited isometric contractions are sufficient to evoke muscle injury in SCI patients. Advisors/Committee Members: Kirk Cureton.

Subjects/Keywords: Spinal cord injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bickel, C. S. (2002). Factors that influence muscle torque after spinal cord injury. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/bickel_christopher_s_200212_phd

Chicago Manual of Style (16^th Edition):

Bickel, Christopher Scott. “Factors that influence muscle torque after spinal cord injury.” 2002. Doctoral Dissertation, University of Georgia. Accessed February 25, 2020. http://purl.galileo.usg.edu/uga_etd/bickel_christopher_s_200212_phd.

MLA Handbook (7^th Edition):

Bickel, Christopher Scott. “Factors that influence muscle torque after spinal cord injury.” 2002. Web. 25 Feb 2020.

Vancouver:

Bickel CS. Factors that influence muscle torque after spinal cord injury. [Internet] [Doctoral dissertation]. University of Georgia; 2002. [cited 2020 Feb 25]. Available from: http://purl.galileo.usg.edu/uga_etd/bickel_christopher_s_200212_phd.

Council of Science Editors:

Bickel CS. Factors that influence muscle torque after spinal cord injury. [Doctoral Dissertation]. University of Georgia; 2002. Available from: http://purl.galileo.usg.edu/uga_etd/bickel_christopher_s_200212_phd

7. Chinthu, Romeo. Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats.

Degree: Biotechnology, 2012, Cochin University of Science and Technology

URL: http://dyuthi.cusat.ac.in/purl/3046

►

The present study deals with the Cholinergic Receptor subtypes functional regulation in spinal cord injured monoplegic rats: Effect of 5-HT GABA and bone marrow cells.Spinal… (more)

▼

The present study deals with the Cholinergic Receptor subtypes functional regulation in spinal cord injured monoplegic rats: Effect of 5-HT GABA and bone marrow cells.Spinal cord injury causes permanent and irrevocable motor deficits and neurodegeneration. Disruption of the spinal cord leads to diminished transmission of descending control from the brain to motor neurons and ascending sensory information. Behavioural studies showed deficits in motor control and coordination in SCI rats. Cholinergic system plays an important role in SCI, the evaluation of which provides valuable insight on the underlying mechanisms of motor deficit that occur during SCI. The cholinergic transmission was studied by assessing the muscarinic and nicotinic receptors; cholinergic enzymes- ChAT and AChE; second messenger enzyme PLC; transcription factor CREB and second messengers - IP3, cAMP and cGMP. We observed a decrease in the cholinergic transmission in the brain and spinal cord of SCI rats. The disrupted cholinergic system is the indicative of motor deficit and neuronal degeneration in the spinal cord and brain regions. SCI mediated oxidative stress and apoptosis leads to neuronal degeneration in SCI rats. The decreased expression of anti oxidant enzymes – SOD, GPx and neuronal cell survival factors - BDNF, GDNF, IGF-1, Akt and cyclin D2 along with increased expression of apoptotic factors – Bax, caspase-8, TNFa and NF-kB augmented the neuronal degeneration in SCI condition. BMC administration in combination with 5-HT and GABA in SCI rats showed a reversal in the impaired cholinergic neurotransmission and reduced the oxidative stress and apoptosis. It also enhanced the expression of cell survival factors in the spinal cord region. In SCI rats treated with 5-HT and GABA, the transplanted BMC expressed NeuN confirming that 5-HT and GABA induced the differentiation and proliferation of BMC to neurons in the spinal cord. Neurotrophic factors and anti-apoptotic elements in SCI rats treated with 5-HT and GABA along with BMC rendered neuroprotective effects accompanied by improvement in behavioural deficits. This resulted in a significant reversal of altered cholinergic neurotransmission in SCI. The restorative and neuro protective effects of BMC in combination with 5-HT and GABA are of immense therapeutic significance in the clinical management of SCI.

Cochin University of Science and Technology

Subjects/Keywords: Spinal cord injury(SCI); Current treatments and its side effects in spinal cord injury; Acetylcholine; Neuronal survival factors in spinal cord injury; Cell therapy in SCI; Apoptosis &Spinal cord Injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chinthu, R. (2012). Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/3046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chinthu, Romeo. “Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats.” 2012. Thesis, Cochin University of Science and Technology. Accessed February 25, 2020. http://dyuthi.cusat.ac.in/purl/3046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chinthu, Romeo. “Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats.” 2012. Web. 25 Feb 2020.

Vancouver:

Chinthu R. Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats. [Internet] [Thesis]. Cochin University of Science and Technology; 2012. [cited 2020 Feb 25]. Available from: http://dyuthi.cusat.ac.in/purl/3046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chinthu R. Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats. [Thesis]. Cochin University of Science and Technology; 2012. Available from: http://dyuthi.cusat.ac.in/purl/3046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Loughborough University

8. Kirkby, Joanna. Resilience in people with spinal cord injury : a narrative approach.

Degree: PhD, 2016, Loughborough University

URL: https://dspace.lboro.ac.uk/2134/23385 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701050

► This PhD thesis explores the phenomenon of resilience in people with spinal cord injury (SCI). The purpose of this research is to understand how resilience… (more)

▼ This PhD thesis explores the phenomenon of resilience in people with spinal cord injury (SCI). The purpose of this research is to understand how resilience is experienced and given meaning in people with SCI, as well how resilience is fostered, how it impacts upon health and well-being, and how it can be managed to achieve maximum benefits with regard to health and well-being. It is the first in depth narrative investigation of resilience in people with SCI. Using both life story interviews and the process of timelining, participants stories were collected. Following this they were then analysed using dialogical narrative analysis (Frank, 2010, 2012). This enabled participants stories to be examined with regard to their effects on resilience and health and well-being. The analysis shows that firstly, due to the intangible nature of resilience, participants had trouble in articulating exactly what resilience meant to them. Instead, resilience was shown through participants stories which could be grouped into four different narrative types: loss, adaptation, posttraumatic growth (PTG), and life-as-normal. Together, these narrative types constructed resilience, and as such, resilience in people with SCI has four facets or faces , like a four-sided dice. The process of resilience in people with SCI worked by participants drawing upon the different narrative types at different times depending upon the demands being placed upon them. The loss narrative was drawn upon immediately following injury, and was concerned with the narration of the physical, psychological and social losses participants incurred following SCI. The loss narrative fostered resilience by enabling participants to talk about their losses, enabling participants to survive the hardest time of their lives. The second narrative type was the adaptation narrative. This narrative type focussed upon rehabilitation in both the spinal unit and in the community. This narrative type built resilience via progression through rehabilitation towards a quality of life comparable to pre-injury levels. The PTG narrative was concerned with the ways in which participants had developed following SCI and built resilience by shifting the focus onto the positives to come out of participants experiences of SCI. The life-as-normal narrative was used by two participants across their entire life story and enabled participants to continue with their lives with minimal disruption. It built resilience by placing disability in the background and therefore making it unimportant. This thesis then concludes with the empirical, theoretical, methodological and practical implications arising from this research. The potential for resilience to help improve the health and well-being of people with SCI is discussed, as well as the ways in which resilience can have a maximum benefit on health and well-being of people with SCI.

Subjects/Keywords: 617.4; Resilience; Spinal cord injury; Disability; Narrative

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kirkby, J. (2016). Resilience in people with spinal cord injury : a narrative approach. (Doctoral Dissertation). Loughborough University. Retrieved from https://dspace.lboro.ac.uk/2134/23385 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701050

Chicago Manual of Style (16^th Edition):

Kirkby, Joanna. “Resilience in people with spinal cord injury : a narrative approach.” 2016. Doctoral Dissertation, Loughborough University. Accessed February 25, 2020. https://dspace.lboro.ac.uk/2134/23385 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701050.

MLA Handbook (7^th Edition):

Kirkby, Joanna. “Resilience in people with spinal cord injury : a narrative approach.” 2016. Web. 25 Feb 2020.

Vancouver:

Kirkby J. Resilience in people with spinal cord injury : a narrative approach. [Internet] [Doctoral dissertation]. Loughborough University; 2016. [cited 2020 Feb 25]. Available from: https://dspace.lboro.ac.uk/2134/23385 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701050.

Council of Science Editors:

Kirkby J. Resilience in people with spinal cord injury : a narrative approach. [Doctoral Dissertation]. Loughborough University; 2016. Available from: https://dspace.lboro.ac.uk/2134/23385 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701050

University of Alberta

9. Krajacic, Aleksandra. Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat.

Degree: PhD, Centre for Neuroscience, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/r207tq51t

► Injury to the cervical spinal cord is a devastating event that results in a transient to permanent loss of sensory and motor functions following injury.… (more)

▼ Injury to the cervical spinal cord is a devastating event that results in a transient to permanent loss of sensory and motor functions following injury. Moderate recovery has been reported to occur in individuals and in animal models after spinal cord injury (SCI). One approach to promote recovery after SCI is rehabilitative training. This thesis examines the relation of reaching training with adaptive changes (i.e. plasticity) and functional recovery following SCI. In my first experiment, I investigated whether plasticity of the corticospinal tract (CST) is the cause for reaching recovery after ablation of the dorsal and lateral CST. Rats that received reaching training were significantly better in reaching than their untrained counterparts. A relesion of the CST revealed that the reaching recovery mainly depended on plasticity of the CST itself. Since it is controversial whether training should be initiated immediately after SCI, I investigated whether a delayed initiation of reaching training after SCI is beneficial. I compared the reaching success of rats that received reaching training on day 4 post SCI with rats that received training on day 12 post SCI. I found that the reaching success in rats that either received reaching training on day 4 or 12 following SCI was similar. Lastly, I investigated whether training efficacy is declined in chronically injured rats. Since it has been shown that the inflammatory response after SCI declines, it is questionable whether there is a relation between the inflammatory response after SCI and training efficacy. In my last experiment I injected chronically injured rats with a substance that induces a systemic inflammation. I found that rehabilitative reaching training in chronic injured rats only resulted in an improved reaching recovery when the training was combined with the administration of the substance that induces inflammation (lipopolysaccharide). Although there are still unanswered questions regarding the underlying mechanism for functional recovery after SCI, the results of this thesis could be used as a basic to improve future rehabilitative training strategies and therefore improve the quality of life in individuals that suffer from SCI.

Subjects/Keywords: reaching; corticospinal; spinal cord injury; lipopolysaccharide

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krajacic, A. (2011). Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/r207tq51t

Chicago Manual of Style (16^th Edition):

Krajacic, Aleksandra. “Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat.” 2011. Doctoral Dissertation, University of Alberta. Accessed February 25, 2020. https://era.library.ualberta.ca/files/r207tq51t.

MLA Handbook (7^th Edition):

Krajacic, Aleksandra. “Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat.” 2011. Web. 25 Feb 2020.

Vancouver:

Krajacic A. Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2020 Feb 25]. Available from: https://era.library.ualberta.ca/files/r207tq51t.

Council of Science Editors:

Krajacic A. Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/r207tq51t

Texas A&M University

10. Erosa, Norma. Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury.

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587

► This dissertation presents the prediction of quality of life (QoL), composed of by life satisfaction and self-perceived health status, across 5 years post a spinal… (more)

▼ This dissertation presents the prediction of quality of life (QoL), composed of by life satisfaction and self-perceived health status, across 5 years post a spinal cord injury (SCI) hospital discharge. Predictor variables of functional independence, pain, and family satisfaction, as mediated by environmental accessibility are examined. Environmental accessibility is conceptualized as being composed of mobility and social integration. Data are a subset from a longitudinal study of adjustment following disability. Two models were examined in order to predict QoL, Model 1 (Life Satisfaction) and Model 2 (Self-Perceived Health Status). Results from this study were obtained by testing models using path modeling. Evaluation indices suggest good to adequate model fit, CFI, RMSEA, and SRMR for Model 1 and Model 2. In Model 1, results indicated that mobility and social integration, components of environmental accessibility, mediated the relationship between functional independence and life satisfaction (beta = 0.243, p = 0.009 and beta = 0.120, p = 0.038, respectively). In Model 2, the component of mobility of environmental accessibility mediated the relationship between functional independence and self-perceived health status (beta = 0.288, p = 0.002). Results indicate that access to the environment is an important predictor of life satisfaction and perceived health status five years after medical discharge for a traumatically-acquired SCI. These factors of environmental access ? mobility and social integration ? appear to be more important determinants of quality of life post-SCI than functional impairment or the presence of pain. Programs that enhance mobility and social integration following return to the community following SCI may be indicated. Furthermore, given that the construct of environmental accessibility is relatively new, studies that examine this construct are needed in order to better understand how it is best conceptualized. Advisors/Committee Members: Elliott, Timothy R. (advisor), Brossart, Daniel (committee member), Rae, William (committee member), Burdine, James (committee member).

Subjects/Keywords: Spinal Cord Injury; Quality of Life

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Erosa, N. (2012). Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Erosa, Norma. “Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury.” 2012. Thesis, Texas A&M University. Accessed February 25, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Erosa, Norma. “Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury.” 2012. Web. 25 Feb 2020.

Vancouver:

Erosa N. Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Erosa N. Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

11. Woller, Sarah Ann. Characterization of Morphine Self-Administration Following Spinal Cord Injury.

Degree: 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151129

► Approximately two-thirds of patients will experience pain following spinal cord injury (SCI). This pain can arise as an immediate consequence of SCI, or can develop… (more)

▼ Approximately two-thirds of patients will experience pain following spinal cord injury (SCI). This pain can arise as an immediate consequence of SCI, or can develop over time into chronic, neuropathic pain. Individuals are frequently prescribed opioid analgesics, including morphine, for the treatment of pain in both the acute and chronic phases of SCI. Yet, despite the prevalence of opioid use, no studies have examined the addictive potential of opioids, or their secondary effects, following spinal injury. These experiments used a clinically relevant self-administration paradigm to examine both addiction and functional recovery after morphine administration. To assess morphine administration in the acute phase of SCI, animals were placed in operant chambers 24-hours following spinal injury. In the chambers, depression of a reinforced lever resulted in an intravenous infusion of morphine (or vehicle). Animals were placed in the chambers for 7, 12-hour sessions and could administer up to 30 mg of morphine per session. Morphine self-administration was also examined in the chronic phase of injury. Animals were placed into operant chambers for 7, 12-hour sessions beginning 14 or 35 days after injury. The amount of morphine administered, as well as recovery of locomotor function and general health, was compared across subjects with SCI and sham (no injury) controls. In the acute phase of injury, SCI significantly reduced self-administration of morphine, but administration led to decreased recovery of locomotor function and weight loss. In the chronic phase of injury, self-administration did not differ between contused and sham animals. All subjects administered the full amount of morphine available each day. In this phase of injury, morphine administration led to significant weight loss, but did not attenuate recovery of locomotor function. These studies suggest that spinal injury reduced the addictive potential of morphine in the acute, but not the chronic, phase of SCI. However, acute administration of high doses of morphine decreased recovery of locomotor function. Morphine should not be used in this phase of injury for the clinical treatment of pain. In the chronic phase, opioid use must be closely monitored as use may result in addictive behavior. Advisors/Committee Members: Hook, Michelle A (advisor), Grau, James W (committee member), Miranda, Rajesh (committee member), Li, Jianrong (committee member).

Subjects/Keywords: spinal cord injury; morphine; self-administration

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Woller, S. A. (2013). Characterization of Morphine Self-Administration Following Spinal Cord Injury. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151129

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Woller, Sarah Ann. “Characterization of Morphine Self-Administration Following Spinal Cord Injury.” 2013. Thesis, Texas A&M University. Accessed February 25, 2020. http://hdl.handle.net/1969.1/151129.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Woller, Sarah Ann. “Characterization of Morphine Self-Administration Following Spinal Cord Injury.” 2013. Web. 25 Feb 2020.

Vancouver:

Woller SA. Characterization of Morphine Self-Administration Following Spinal Cord Injury. [Internet] [Thesis]. Texas A&M University; 2013. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1969.1/151129.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Woller SA. Characterization of Morphine Self-Administration Following Spinal Cord Injury. [Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151129

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

12. Diaz Quiroz, Juan Felipe. Comparative analysis of the molecular pathways involved in spinal cor injury in axolotls vs. mammaals.

Degree: PhD, Molecular, Cellular, Developmental Biology and Genetics, 2015, University of Minnesota

URL: http://hdl.handle.net/11299/181717

► Spinal cord injuries (SCI) in mammals are major causes of physical disabilities. In contrast the Mexican salamander (axolotl) possesses amazing regenerative capabilities and can regenerate… (more)

▼ Spinal cord injuries (SCI) in mammals are major causes of physical disabilities. In contrast the Mexican salamander (axolotl) possesses amazing regenerative capabilities and can regenerate a fully functional spinal cord after injury. We have attempted to identify the molecular determinants underlying this evolutionary divergence by undertaking a detailed comparative analysis of a regenerative model, the axolotl spinal cord, and a corresponding non-regenerative system, rat spinal cord after injury. This approach identified a small number of highly conserved microRNAs that are differentially regulated in axolotl versus. Detailed in vivo studies of one of these microRNAs, miR-125b that is highly expressed in axolotl but low in rat has identified it as a key regulator of the regenerative response in axolotl. We also found that upregulation of miR-125b after injury improves SC repair in rats. In addition, we have identified SEMA4D as a target gene regulated by this microRNA after SCI in both axolotl and rat. We also studied how this miRNA is regulated in the axolotl to promote regeneration after SCI. We found that in the absence of injury, actin cytoskeleton de-polymerization induced by Cytochalasin D (Cyto D) induced a decrease in miR-125b expression similar to the decrease induced by injury in axolotl. Analyses of the regulatory region of the miR-125b axolotl gene revealed predicted binding sites for c-Fos. When we performed SCI in axolotls, we observed an increase in the expression of c-Fos 1 day after injury. As expected, we found that in the absence of injury, treatment with Cyto D induced similar changes in c-Fos expression similar to injury. Lastly, we proposed the development of a 3D in vitro co-culture model system to study at the cellular and molecular level how miR-125b SCI regulates the response to injury in rats and whether miR-125b expression is regulated by biomechanical activation of the Rho-c-Fos pathway. The proposed model will allow better imaging, better spatial and temporal control over modulating microRNA and gene expression in different cells at different time points. Our overall data suggest that dynamic changes in the actin cytoskeleton after injury induces changes in miR-125b expression, possibly through activation of cFos in the RhoA pathway, to create a permissive environment for regeneration in axolotls.

Subjects/Keywords: Axolotl; Cytoskeleton; microRNA; Regeneration; Spinal cord Injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Diaz Quiroz, J. F. (2015). Comparative analysis of the molecular pathways involved in spinal cor injury in axolotls vs. mammaals. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/181717

Chicago Manual of Style (16^th Edition):

Diaz Quiroz, Juan Felipe. “Comparative analysis of the molecular pathways involved in spinal cor injury in axolotls vs. mammaals.” 2015. Doctoral Dissertation, University of Minnesota. Accessed February 25, 2020. http://hdl.handle.net/11299/181717.

MLA Handbook (7^th Edition):

Diaz Quiroz, Juan Felipe. “Comparative analysis of the molecular pathways involved in spinal cor injury in axolotls vs. mammaals.” 2015. Web. 25 Feb 2020.

Vancouver:

Diaz Quiroz JF. Comparative analysis of the molecular pathways involved in spinal cor injury in axolotls vs. mammaals. [Internet] [Doctoral dissertation]. University of Minnesota; 2015. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/11299/181717.

Council of Science Editors:

Diaz Quiroz JF. Comparative analysis of the molecular pathways involved in spinal cor injury in axolotls vs. mammaals. [Doctoral Dissertation]. University of Minnesota; 2015. Available from: http://hdl.handle.net/11299/181717

University of Newcastle

13. Flynn, Jamie R. Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons.

Degree: PhD, 2015, University of Newcastle

URL: http://hdl.handle.net/1959.13/1296580

►

Research Doctorate - Doctor of Philopsophy (PhD)

The work presented in this thesis had two major aims. The first was to develop an in vitro… (more)

Subjects/Keywords: spinal cord injury; electrophysiology; propriospinal; interneuron

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Flynn, J. R. (2015). Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1296580

Chicago Manual of Style (16^th Edition):

Flynn, Jamie R. “Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons.” 2015. Doctoral Dissertation, University of Newcastle. Accessed February 25, 2020. http://hdl.handle.net/1959.13/1296580.

MLA Handbook (7^th Edition):

Flynn, Jamie R. “Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons.” 2015. Web. 25 Feb 2020.

Vancouver:

Flynn JR. Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1959.13/1296580.

Council of Science Editors:

Flynn JR. Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1296580

University of Rochester

14. Robak, Laurie. The Structural Basis of the Interaction between Myelin-Associated Glyoprotein and Nogo Receptor 2 : Design of Novel Therapeutic Agents for Spinal Cord.

Degree: PhD, 2009, University of Rochester

URL: http://hdl.handle.net/1802/8294

► Myelin-associated glycoprotein (MAG) is a sialic acid binding Ig-family lectin that functions in neuronal growth inhibition and stabilization of axon-glia interactions. The ectodomain of MAG… (more)

Subjects/Keywords: MAG; NgR2; Gangliosides; Spinal Cord Injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Robak, L. (2009). The Structural Basis of the Interaction between Myelin-Associated Glyoprotein and Nogo Receptor 2 : Design of Novel Therapeutic Agents for Spinal Cord. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/8294

Chicago Manual of Style (16^th Edition):

Robak, Laurie. “The Structural Basis of the Interaction between Myelin-Associated Glyoprotein and Nogo Receptor 2 : Design of Novel Therapeutic Agents for Spinal Cord.” 2009. Doctoral Dissertation, University of Rochester. Accessed February 25, 2020. http://hdl.handle.net/1802/8294.

MLA Handbook (7^th Edition):

Robak, Laurie. “The Structural Basis of the Interaction between Myelin-Associated Glyoprotein and Nogo Receptor 2 : Design of Novel Therapeutic Agents for Spinal Cord.” 2009. Web. 25 Feb 2020.

Vancouver:

Robak L. The Structural Basis of the Interaction between Myelin-Associated Glyoprotein and Nogo Receptor 2 : Design of Novel Therapeutic Agents for Spinal Cord. [Internet] [Doctoral dissertation]. University of Rochester; 2009. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1802/8294.

Council of Science Editors:

Robak L. The Structural Basis of the Interaction between Myelin-Associated Glyoprotein and Nogo Receptor 2 : Design of Novel Therapeutic Agents for Spinal Cord. [Doctoral Dissertation]. University of Rochester; 2009. Available from: http://hdl.handle.net/1802/8294

Universiteit Utrecht

15. Sagel, D.C. Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/321298

► Rationale: A new instrument for emergency medical services has been developed to detect symptoms of spinal cord injury and enables patients to receive appropriate care… (more)

Subjects/Keywords: EMS; Spinal cord injury; Emergency medicine; implementation.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sagel, D. C. (2015). Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/321298

Chicago Manual of Style (16^th Edition):

Sagel, D C. “Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study.” 2015. Masters Thesis, Universiteit Utrecht. Accessed February 25, 2020. http://dspace.library.uu.nl:8080/handle/1874/321298.

MLA Handbook (7^th Edition):

Sagel, D C. “Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study.” 2015. Web. 25 Feb 2020.

Vancouver:

Sagel DC. Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study. [Internet] [Masters thesis]. Universiteit Utrecht; 2015. [cited 2020 Feb 25]. Available from: http://dspace.library.uu.nl:8080/handle/1874/321298.

Council of Science Editors:

Sagel DC. Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study. [Masters Thesis]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/321298

University of California – San Diego

16. Corleto, Jose Alfredo. Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat.

Degree: Biomedical Sciences, 2016, University of California – San Diego

URL: http://www.escholarship.org/uc/item/64h01790

► Spinal cord injury is a problem that carries with it many implications including changes in motor circuit action that then lead to development of muscle… (more)

▼ Spinal cord injury is a problem that carries with it many implications including changes in motor circuit action that then lead to development of muscle spasticity, hyperreflexia, and loss of inhibitory response stemming from injury. These changes contribute to muscle spasms elicited by casual stimulation of afferent fibers that then lead to changes in muscle action and to a decrease in the quality of life. Here, we developed a thoracic 9 spinal cord transection injury model in Sprague-Dawley rats to study the changes in motor circuitry in these paraplegic rats. For the first part of my thesis work, we used electrophysiology in this SCI model to study the development of gastrocnemius muscle spasticity, and also the presence of electrical stimulation- and tactile-evoked hyperreflexia at chronic phase following injury. The second part of my thesis focused on the use of clinical pharmacology (Baclofen, GABAb agonist and Tizanidine, α2 adrenergic agonist) and non-used avenues (NGX424, ampa/kainate antagonist) to look at the amelioration of spasticity and spinal hyper-reflexia. The third part of my thesis was aimed at using experimental gene therapy and to test the effect of spinal GAD65 gene upregulation (as achieved by spinal IT or SP AAV9-GAD65 delivery) on chronic spasticity.Our results are sequentially organized as follows: 1) Characterization of time-dependent appearance of muscle spasticity and spinal hyper-reflexia after spinal Th9 transection in rat as defined by i) ankle-rotation evoked increase in muscle resistance, ii) tactile stimulus-evoked EMG response, and iii) electrical stimulus (H-reflex) defined muscle hyper-reflexia. 2) Characterization of anti-spastic potency of clinically validated anti-spastic agents in rat Th 9 spinal transection-induced chronic spasticity model. 3) Effect of spinal GAD65 gene upregulation in combination with systemic tiagabine (GABA uptake inhibitor) treatment on chronic muscle spasticity. In conclusion, my work has demonstrated that our T9 TSCT model can recapitulate several pathologic neurological phenotypes (muscle spasticity, spinal hyper-reflexia) seen in human patients suffering from chronic spinal cord injury. Chronic muscle spasticity measured in the rat model is effectively suppressed by clinically validated anti-spastic agents, which suggests that this model represents an appropriate avenue for development of new anti-spastic therapies.

Subjects/Keywords: Biology; Gene Therapy; Pharmacology; Spinal Cord Injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Corleto, J. A. (2016). Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/64h01790

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Corleto, Jose Alfredo. “Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat.” 2016. Thesis, University of California – San Diego. Accessed February 25, 2020. http://www.escholarship.org/uc/item/64h01790.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Corleto, Jose Alfredo. “Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat.” 2016. Web. 25 Feb 2020.

Vancouver:

Corleto JA. Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat. [Internet] [Thesis]. University of California – San Diego; 2016. [cited 2020 Feb 25]. Available from: http://www.escholarship.org/uc/item/64h01790.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Corleto JA. Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat. [Thesis]. University of California – San Diego; 2016. Available from: http://www.escholarship.org/uc/item/64h01790

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Saskatchewan

17. Hassan, Atiq. Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury.

Degree: 2015, University of Saskatchewan

URL: http://hdl.handle.net/10388/ETD-2015-09-2235

► Many experimental therapies have been used in the search for effective approaches to improve recovery after spinal cord injury (SCI). One of the most promising… (more)

▼ Many experimental therapies have been used in the search for effective approaches to improve recovery after spinal cord injury (SCI). One of the most promising approaches is the augmentation of spontaneously occurring plasticity in uninjured neural pathways. Acute intermittent hypoxia (AIH-brief exposures to reduced O2 levels alternating with normal O2 levels) elicits plasticity in respiratory and non-respiratory spinal systems in experimental animals. AIH treatment has also been shown to improve walking abilities in persons with chronic incomplete SCI. In this thesis, I first examined the effect of AIH treatment, alone or in combination with motor training, on functional recovery in a rat model of incomplete cervical SCI. Second, I examined the effect of AIH on the expression of plasticity- and hypoxia-related proteins in the spinal cords of SCI rats. In a randomized, blinded, normoxia-controlled study, rats were trained to cross a horizontal ladder and footslip errors were measured before surgery for SCI, 4 wks post-surgery, each day of daily AIH treatment, and 1, 2, 4 and 8 weeks after treatment. dAIH treatment consisted of 10 episodes of AIH: (5 min 11% O2: 5 min 21% O2) for 7 days beginning at 4 wks post-SCI. AIH-treated rats made fewer footslips on the ladder task compared to normoxia-treated control rats after 4 days of treatment and this improvement was sustained for 8 wks post-treatment. Importantly, daily ladder training was required for AIH treatment to facilitate recovery. AIH treatment + motor training also increased the expression of Hypoxia-inducible factor-1α (HIF-1α), Vascular endothelial growth factor (VEGF), Brain-derived neurotrophic factor (BDNF), tyrosine kinase B receptors (trkB) and phospho-trkB in spinal motor neurons in SCI rats compared to normoxia-treated SCI rats. In particular these hypoxia- and plasticity-related proteins were differentially expressed both temporally and spatially in the spinal cord during AIH treatment. These findings demonstrate that AIH + motor training can augment neural plasticity and improve motor recovery in an animal model of SCI. Taken together with the promising findings from human SCI studies, the results of this thesis suggest that AIH has potential as an effective therapy to restore motor function after nervous system injury. Advisors/Committee Members: Muir, Gillian D., Machin, Karen, Weber, Lynn, Verge, Valerie, Paterson, Phyllis.

Subjects/Keywords: Intermittent hypoxia; Plasticity; Spinal cord injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hassan, A. (2015). Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2015-09-2235

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hassan, Atiq. “Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury.” 2015. Thesis, University of Saskatchewan. Accessed February 25, 2020. http://hdl.handle.net/10388/ETD-2015-09-2235.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hassan, Atiq. “Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury.” 2015. Web. 25 Feb 2020.

Vancouver:

Hassan A. Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury. [Internet] [Thesis]. University of Saskatchewan; 2015. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10388/ETD-2015-09-2235.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hassan A. Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury. [Thesis]. University of Saskatchewan; 2015. Available from: http://hdl.handle.net/10388/ETD-2015-09-2235

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

18. Ektas, Nalan. Design and Evaluation of an FES-Assisted Rowing System for Individuals with Spinal Cord Injury .

Degree: 2016, University of Sydney

URL: http://hdl.handle.net/2123/15258

► Exercise and physical activity have been demonstrated to have potent effects on health outcomes, aerobic fitness and muscular strength in individuals with spinal cord injury… (more)

▼ Exercise and physical activity have been demonstrated to have potent effects on health outcomes, aerobic fitness and muscular strength in individuals with spinal cord injury (SCI). However, exercise opportunities for the SCI population are limited and special consideration is required, so as not to compromise the performance of daily activities such as wheelchair propulsion, weight relief and transfers. While physical activities have traditionally consisted of upper body exercise or wheelchair sports, advancement in functional electrical stimulation (FES) technology has facilitated the development of dynamic leg exercise modalities for individuals with lower limb paralysis or paresis. Furthermore, the combination of voluntary upper body exercise with lower limb FES has been demonstrated to increase the ‘dose potency’ of exercise to the requisite intensity necessary for enhancing physical fitness. FES-assisted rowing has recently been developed as a ‘hybrid’ exercise modality for SCI rehabilitation. Pilot studies have determined FES rowing to be welltolerated, with the benefits of increased exercise intensity for health outcomes. This thesis has investigated the development of FES rowing as an exercise modality for individuals with SCI, in order to develop a new approach which addressed the limitations of existing designs. The design and evaluation of a novel prototype FES rowing system, which comprised a floating foot stretcher, is presented herein. The limitations of existing FES rowing systems and future directions for research were first investigated in a narrative review that explored the evolution of FES rowing system designs, and evaluated the physiological and biomechanical outcomes of FES rowing. The outcome of this review identified a number of limitations associated with existing FES rowing implementations, which were largely based on fixed ergometer designs, where the rower pushes off a fixed foot stretcher and accelerates their body back and forth on a sliding rail. These limitations included early onset of leg muscle fatigue and insufficient muscle strength to successfully complete the rowing stroke. The deployment of floating stretcher ergometer was suggested as an alternative design that might address the issues associated with fixed foot stretcher ergometer designs. The review also identified further biomechanical characterisation as a potential area for research, due to the limited availability of literature examining the stroke mechanics of FES rowing. Following the outcomes of this review, a floating stretcher FES rowing system was constructed. This system was the first of its kind to integrate a commercial FES stimulator iii with an adapted RowperfectTM rowing ergometer, which has a sliding foot stretcher as the basis of its design. The FES rowing system prototype was found to be well tolerated by the SCI participants who evaluated the device. The hardware/software solution that was adopted enabled acquisition of accurate force and displacement data that could be…

Subjects/Keywords: Electrical stimulation; Rowing; Spinal cord injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ektas, N. (2016). Design and Evaluation of an FES-Assisted Rowing System for Individuals with Spinal Cord Injury . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/15258

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ektas, Nalan. “Design and Evaluation of an FES-Assisted Rowing System for Individuals with Spinal Cord Injury .” 2016. Thesis, University of Sydney. Accessed February 25, 2020. http://hdl.handle.net/2123/15258.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ektas, Nalan. “Design and Evaluation of an FES-Assisted Rowing System for Individuals with Spinal Cord Injury .” 2016. Web. 25 Feb 2020.

Vancouver:

Ektas N. Design and Evaluation of an FES-Assisted Rowing System for Individuals with Spinal Cord Injury . [Internet] [Thesis]. University of Sydney; 2016. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/2123/15258.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ektas N. Design and Evaluation of an FES-Assisted Rowing System for Individuals with Spinal Cord Injury . [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/15258

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Hong, Le Thi Anh. Bridging the lesioned spinal cord using hydrogel.

Degree: 2015, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/11835 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728

►

I. INTRODUCTION 1 A. Spinal Cord Injury 1 B. Cavity formation and the importance of bridging lesion after spinal cord injury. 2 C. Bridging cavity… (more)

Subjects/Keywords: Spinal cord injury; hydrogel; extracullular matrix

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hong, L. T. A. (2015). Bridging the lesioned spinal cord using hydrogel. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/11835 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hong, Le Thi Anh. “Bridging the lesioned spinal cord using hydrogel.” 2015. Thesis, Ajou University. Accessed February 25, 2020. http://repository.ajou.ac.kr/handle/201003/11835 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hong, Le Thi Anh. “Bridging the lesioned spinal cord using hydrogel.” 2015. Web. 25 Feb 2020.

Vancouver:

Hong LTA. Bridging the lesioned spinal cord using hydrogel. [Internet] [Thesis]. Ajou University; 2015. [cited 2020 Feb 25]. Available from: http://repository.ajou.ac.kr/handle/201003/11835 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hong LTA. Bridging the lesioned spinal cord using hydrogel. [Thesis]. Ajou University; 2015. Available from: http://repository.ajou.ac.kr/handle/201003/11835 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McGill University

20. Deutsch, Luisa. Evaluation of a Centralized System in the Management of Patients with Spinal Cord Injuries.

Degree: MS, Department of Surgery, 2004, McGill University

URL: http://digitool.library.mcgill.ca/thesisfile161892.pdf

►

Note:

This study evaluates the establishment of a centralized system for the treatment of patients with spinal cord injuries. This model system was initiated in… (more)

▼

Note:

This study evaluates the establishment of a centralized system for the treatment of patients with spinal cord injuries. This model system was initiated in the United States and adapted for Quebec. Data from the United States has demonstrated reduced mortality, decreased hospitalization, and improved patient outcome. Prior to the present research, this new intervention had not been evaluated in Quebec. This study is based at Hopital du Sacre-Coeur and at Institut de Readaptation de Montreal (IRM). This is a retrospective/prospective cohort study of all patients treated at Hopital du Sacre-Coeur and IRM during the study period. The patients were classified in the following cohorts: 1995-1997: pre-implementation, 1997-1998: implementation of the centralized system, and 1998-2000: post-implementation.Analysis revealed a significant decrease in complications, a significant decrease in the total length of hospital stay, and a significant decrease in rehabilitation stay for the post-implementation cohort. There was no significant difference between the three cohorts in terms of detrimental effects.

La récupération post-chirurgicale comprend une période ou les capacités fonctionnelles sont diminuées et pendant laquelle les patients sont incapables de fonctionner au même niveau qu'avant l'opération. Traditionnellement, on étudiait cette période à I' aide de critères comme la durée du séjour hospitalier et le retour au travail, qui se confondent avec les variables psychosociales et de comorbidité. Les critères centres sur le patient comme les capacités fonctionnelles, la qualité de vie et la réintégration sont plus informatifs et valides. Le prélèvement d'un rein par laparoscopie sur un donneur vivant a permis l'étudier la récupération en utilisant des instruments valides et standardises mesurant capacité d'exercice, qualité de vie, douleur et fatigue. Quatre semaines après le prélèvement du rein, les patients ont retrouvé leur capacité d'exercice initiale, mais pas leur santé physique générale de départ. Les mesures traditionnelles s'avèrent inadéquates pour décrire la récupération lorsqu'on utilise les mesures standardisées comme référence.

Advisors/Committee Members: Sampalis, John S. (Supervisor).

Subjects/Keywords: Spinal cord injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deutsch, L. (2004). Evaluation of a Centralized System in the Management of Patients with Spinal Cord Injuries. (Masters Thesis). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile161892.pdf

Chicago Manual of Style (16^th Edition):

Deutsch, Luisa. “Evaluation of a Centralized System in the Management of Patients with Spinal Cord Injuries.” 2004. Masters Thesis, McGill University. Accessed February 25, 2020. http://digitool.library.mcgill.ca/thesisfile161892.pdf.

MLA Handbook (7^th Edition):

Deutsch, Luisa. “Evaluation of a Centralized System in the Management of Patients with Spinal Cord Injuries.” 2004. Web. 25 Feb 2020.

Vancouver:

Deutsch L. Evaluation of a Centralized System in the Management of Patients with Spinal Cord Injuries. [Internet] [Masters thesis]. McGill University; 2004. [cited 2020 Feb 25]. Available from: http://digitool.library.mcgill.ca/thesisfile161892.pdf.

Council of Science Editors:

Deutsch L. Evaluation of a Centralized System in the Management of Patients with Spinal Cord Injuries. [Masters Thesis]. McGill University; 2004. Available from: http://digitool.library.mcgill.ca/thesisfile161892.pdf

The Ohio State University

21. Hansen, Christopher Nelson. REMOTE DISRUPTION OF FUNCTION, PLASTICITY, AND LEARNING IN LOCOMOTOR NETWORKS AFTER SPINAL CORD INJURY.

Degree: PhD, Neuroscience Graduate Studies Program, 2013, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1385716231

► Spinal cord injury (SCI) creates a diverse range of functional outcomes. Impaired locomotion may be the most noticeable and debilitating consequence. Locomotor patterns result from… (more)

▼ Spinal cord injury (SCI) creates a diverse range of functional outcomes. Impaired locomotion may be the most noticeable and debilitating consequence. Locomotor patterns result from a dynamic interaction between sensory and motor systems in the lumbar enlargement of the spinal cord. After SCI, conflicting cellular and molecular processes initiate along the neuroaxis that may secondarily jeopardize function, plasticity, and learning within locomotor networks. Thus, we used a standardized thoracic contusion to replicate human pathology and identified behavioral, physiological, cellular, and molecular effects in rat and mouse models. Specifically, our goal was to identify kinematic and neuromotor changes during locomotion, evaluate the role of axonal sparing on remote spinal learning, and identify mechanisms of neuroinflammation in the lumbar enlargement that may prevent locomotor plasticity after SCI. Eccentric muscle actions require precise segmental integration of sensory and motor signals. Eccentric motor control is predominant during the yield (E2) phase of locomotion. To identify kinematic and neuromotor changes in E2, we used a mild SCI that allows almost complete functional recovery. Remaining deficits included a caudal shift in locomotor subphases that accompanied a marked reduction in eccentric angular excursions and intralimb coordination. Underlying these metrics, we found distinct bursting impairments in the semitendinosus. Phasic impairments during the eccentric activation of the semitendinosus improved over time and predicted the extent of recovery. Our findings suggest that maladaptive integration of descending and afferent signals limit central pattern generator-directed locomotion after SCI. Axonal sparing after SCI facilitates plasticity rostral and caudal to the lesion. To evaluate the role of axonal sparing on remote lumbar plasticity, we examined learning in isolated lumbar segments early (7d) and late (42d) after SCI. A proof of principle design compared rats that recovered with or without sparing. Early after SCI, learning was impaired regardless of sparing. Alternatively, axonal sparing during recovery allowed near-normal learning late after SCI. To determine if eccentric task-specific training differentially regulates spinal learning, we delivered flat or downhill treadmill training late after recovery from incomplete SCI (34-41d). Downhill treadmill training improved recovery and central learning. This work identifies a time dependent interaction between spared axonal systems and task-specific plasticity in locomotor networks. To determine if remote mechanisms of neuroinflammation impede locomotor plasticity, we conducted a series of experiments in wild type (WT) and genetically engineered (KO) mice. Within 24h in WT mice, resident microglia displayed an inflammatory phenotype alongside increased expression of pro-gelatinase, MMP-3. By 7 and 9d, MMP-9 and TNFa reached significant elevations alongside persistent activation of resident microglia. In MMP-9 null (KO) mice, inflammatory signaling… Advisors/Committee Members: Basso, D. Michele (Advisor).

Subjects/Keywords: Neurosciences; Spinal Cord Injury, Locomotion, Neuroinflammation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hansen, C. N. (2013). REMOTE DISRUPTION OF FUNCTION, PLASTICITY, AND LEARNING IN LOCOMOTOR NETWORKS AFTER SPINAL CORD INJURY. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1385716231

Chicago Manual of Style (16^th Edition):

Hansen, Christopher Nelson. “REMOTE DISRUPTION OF FUNCTION, PLASTICITY, AND LEARNING IN LOCOMOTOR NETWORKS AFTER SPINAL CORD INJURY.” 2013. Doctoral Dissertation, The Ohio State University. Accessed February 25, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385716231.

MLA Handbook (7^th Edition):

Hansen, Christopher Nelson. “REMOTE DISRUPTION OF FUNCTION, PLASTICITY, AND LEARNING IN LOCOMOTOR NETWORKS AFTER SPINAL CORD INJURY.” 2013. Web. 25 Feb 2020.

Vancouver:

Hansen CN. REMOTE DISRUPTION OF FUNCTION, PLASTICITY, AND LEARNING IN LOCOMOTOR NETWORKS AFTER SPINAL CORD INJURY. [Internet] [Doctoral dissertation]. The Ohio State University; 2013. [cited 2020 Feb 25]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1385716231.

Council of Science Editors:

Hansen CN. REMOTE DISRUPTION OF FUNCTION, PLASTICITY, AND LEARNING IN LOCOMOTOR NETWORKS AFTER SPINAL CORD INJURY. [Doctoral Dissertation]. The Ohio State University; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1385716231

University of Ghana

22. Ampah, B.T. Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital.

Degree: 2018, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/28362

► Nurses encounter several challenges in managing patients with spinal cord injury. However, little is known about this area of nursing care. Thus the purpose of… (more)

Subjects/Keywords: Spinal Cord Injury; Korle-Bu Teaching Hospital

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ampah, B. T. (2018). Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/28362

Chicago Manual of Style (16^th Edition):

Ampah, B T. “Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. ” 2018. Masters Thesis, University of Ghana. Accessed February 25, 2020. http://ugspace.ug.edu.gh/handle/123456789/28362.

MLA Handbook (7^th Edition):

Ampah, B T. “Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. ” 2018. Web. 25 Feb 2020.

Vancouver:

Ampah BT. Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. [Internet] [Masters thesis]. University of Ghana; 2018. [cited 2020 Feb 25]. Available from: http://ugspace.ug.edu.gh/handle/123456789/28362.

Council of Science Editors:

Ampah BT. Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. [Masters Thesis]. University of Ghana; 2018. Available from: http://ugspace.ug.edu.gh/handle/123456789/28362

McMaster University

23. Piran, Siavash. THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY.

Degree: MSc, 2018, McMaster University

URL: http://hdl.handle.net/11375/24093

►

Patients with acute spinal cord injury (SCI) have a high risk of venous thromboembolism (VTE) despite receiving thromboprophylaxis. The current standard of care recommended by… (more)

▼

Patients with acute spinal cord injury (SCI) have a high risk of venous thromboembolism (VTE) despite receiving thromboprophylaxis. The current standard of care recommended by guidelines is to use low-molecular-weight heparin (LMWH) for thromboprophylaxis for 90 days. This entails once- or twice-daily subcutaneous injections of LMWH for this duration, which is inconvenient for the patients and only partially effective. There are uncertainties about risk factors and the true incidence of SCI-associated VTE, the optimal time to commence thromboprophylaxis, and the optimal duration of thromboprophylaxis. Furthermore, there are currently no studies on the use of direct oral anticoagulants (DOACs) for thromboprophylaxis in patients with SCI. The use of DOACs for prophylaxis in this group can eliminate the inconvenience associated with daily subcutaneous injections for 3 months. To examine the incidence and risk factors of SCI-associated VTE, we performed a retrospective chart review of consecutive adult patients with acute SCI admitted to Hamilton General hospital from 2009 to 2015. The incidence of symptomatic VTE despite the use of thromboprophylaxis was 11% within 90 days of acute SCI; age and presence of other sites of injuries (such as lower limb fractures or pelvic fractures) along with SCI were independent risk factors for symptomatic VTE. To determine the opinion of Canadian spine surgeons about the optimal timing of starting LMWH after acute SCI, a short 5-question electronic survey was sent to the Canadian Spine Society. Data from our survey showed that the understanding about thromboprophylaxis after acute SCI was variable and that most spine surgeons were comfortable with starting LMWH after consultation with the surgeon. Future studies should focus on educational strategies to improve the knowledge base in this area. We will perform a pilot study at the Hamilton General Hospital comparing apixaban versus LMWH for thromboprophylaxis in patients with acute SCI. The use of apixaban for this indication can contribute to cost savings for the healthcare system and increased convenience for the patient. The protocol for the pilot study as well as steps towards a multi-center randomized controlled trial will be detailed in this thesis.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Schulman, Sam, Health Research Methodology.

Subjects/Keywords: Thromboprophylaxis; Spinal Cord Injury; Pilot Study

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Piran, S. (2018). THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24093

Chicago Manual of Style (16^th Edition):

Piran, Siavash. “THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY.” 2018. Masters Thesis, McMaster University. Accessed February 25, 2020. http://hdl.handle.net/11375/24093.

MLA Handbook (7^th Edition):

Piran, Siavash. “THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY.” 2018. Web. 25 Feb 2020.

Vancouver:

Piran S. THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY. [Internet] [Masters thesis]. McMaster University; 2018. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/11375/24093.

Council of Science Editors:

Piran S. THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY. [Masters Thesis]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/24093

University of Adelaide

24. Leonard, Anna Victoria. Characterising the role of substance P following traumatic spinal cord injury.

Degree: 2012, University of Adelaide

URL: http://hdl.handle.net/2440/87149

► Spinal cord injury (SCI) is a devastating injury that commonly results in permanent physical disability. The highest incidence of SCI occurs in younger populations, causing… (more)

▼ Spinal cord injury (SCI) is a devastating injury that commonly results in permanent physical disability. The highest incidence of SCI occurs in younger populations, causing an enormous financial burden to both individuals and society amounting to almost $1 billion annually within Australia spent on hospitalisation, treatment and rehabilitation of spinal cord injured individuals. To date, an effective clinical treatment for SCI remains elusive, highlighting the need for research aimed at developing therapeutic interventions that improve functional outcome. Spinal cord edema is recognised as a common complication of SCI which continues to develop, spreading in a rostrocaudal direction days after injury, resulting in greater tissue damage and functional deficits. Reducing edema following SCI is therefore of utmost importance and represents an attractive target for therapeutic intervention. Substance P (SP) is a neuropeptide known to facilitate the process of neurogenic inflammation, which has previously been shown to result in blood brain barrier (BBB) disruption and subsequent edema development following both traumatic brain injury (TBI) and stroke. Furthermore, inhibition of the high-affinity SP receptor, the tachykinin NK1 receptor, resulted in reduced BBB permeability, edema and improved functional outcome in both of these conditions. Accordingly, the current thesis sought to determine whether SP played a similar role as a mediator of neurogenic inflammation following traumatic SCI. Immunohistochemical assessment of human SCI demonstrated a loss of SP from the dorsal horn region, suggesting that SP release increased following injury. NK1 receptor immunoreactivity was also initially increased post-injury before declining, indicating that receptor activation and subsequent internalisation occurred. Assessment of various open experimental injury models, including the weight drop, hemisection and clip compression models, demonstrated similar SP immunoreactivity as that observed in human tissue, although NK1 receptor immunoreactivity varied in localisation and response to injury. These results highlighted the need for experimental models to accurately replicate the primary injury mechanisms observed clinically, especially the closed environment rather than the open nature of most experimental models. The balloon compression model was subsequently employed for the remainder of the study, given its closed nature and its ability to mimic primary injury mechanisms such as an initial impact followed by persisting compression. This model also proved to replicate many other facets of human injury such as severe hemorrhage, axonal injury, neuronal loss, microglial activation, as well as increased BSCB disruption, edema, intrathecal pressure (ITP) and reduced functional outcome. Balloon compression induced SCI was also associated with reduced SP immunoreactivity, suggesting increased SP release, and increased NK1 receptor immunoreactivity. Such observations implicate a potential role for SP in mediating neurogenic inflammation… Advisors/Committee Members: Vink, Robert (advisor), Blumbergs, Peter Charles (advisor), School of Medical Sciences (school).

Subjects/Keywords: spinal cord injury; substance P; neurogenic inflammation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leonard, A. V. (2012). Characterising the role of substance P following traumatic spinal cord injury. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/87149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leonard, Anna Victoria. “Characterising the role of substance P following traumatic spinal cord injury.” 2012. Thesis, University of Adelaide. Accessed February 25, 2020. http://hdl.handle.net/2440/87149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leonard, Anna Victoria. “Characterising the role of substance P following traumatic spinal cord injury.” 2012. Web. 25 Feb 2020.

Vancouver:

Leonard AV. Characterising the role of substance P following traumatic spinal cord injury. [Internet] [Thesis]. University of Adelaide; 2012. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/2440/87149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leonard AV. Characterising the role of substance P following traumatic spinal cord injury. [Thesis]. University of Adelaide; 2012. Available from: http://hdl.handle.net/2440/87149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

25. Moulds, Jessica. The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3789

► At present there is only limited research on the nutrition knowledge and dietary practices of athletes with a disability. The physiological differences in athletes with… (more)

▼ At present there is only limited research on the nutrition knowledge and dietary practices of athletes with a disability. The physiological differences in athletes with disabilities combined with the internal demands and external pressures during sporting events, predispose them to medical and health problems. The growing participation of athletes with disabilities in sporting events such as the Paralympic Games denotes the need for nutrition guidelines specific for these athletes to be produced. Most elite able-bodied athletes have access to nutritional support and education, however, such resources are more difficult for those with disabilities to utilise. Therefore, this study aimed to investigate the basic and sports nutrition knowledge, dietary practices and nutrition education sources of athletes with spinal cord injuries (SCI) compared with their able-bodied (AB) counterparts, using a self-developed questionnaire. Twenty-nine athletes (11 AB, 18 SCI) completed the questionnaire. Overall, there was no significant difference in the nutritional knowledge between athletes with SCI and AB athletes (p=0.4709). However, the results from this study did find potential gaps in nutrition knowledge for both groups. In particular, both groups showed poor knowledge for the role of macronutrients in the body. For example, 36% AB and 56% SCI incorrectly agreed that the more protein you consume, the more muscle you build. There was also a significant difference (p=0.029) between the groups perceived body weight as 27% AB and 67% SCI consider themselves as above their ideal weight. Only 20% of SCI athletes consider their weight as “ideal” compared with 64% of AB athletes. These results indicate that athletes with SCI are more likely to struggle with their weight than AB athletes. Both groups indicated that an individual session with a sports nutritionist or dietitian is the preferred source of nutrition information, although, SCI athletes also reported the internet and interactive website programs to be another good source of nutrition information. More research is needed to assess the overall knowledge of disabled athletes in comparison to their able-bodied counterparts as well as the most appropriate, and effective methods of education for this group. Advisors/Committee Members: Black, Katherine (advisor).

Subjects/Keywords: Nutrition; Knowledge; Spinal; Cord; Injury; Athletes

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moulds, J. (2013). The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3789

Chicago Manual of Style (16^th Edition):

Moulds, Jessica. “The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries .” 2013. Masters Thesis, University of Otago. Accessed February 25, 2020. http://hdl.handle.net/10523/3789.

MLA Handbook (7^th Edition):

Moulds, Jessica. “The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries .” 2013. Web. 25 Feb 2020.

Vancouver:

Moulds J. The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10523/3789.

Council of Science Editors:

Moulds J. The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3789

University of Otago

26. Shaw, David. Nutritional supplement knowledge of athletes with spinal cord injury .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3795

► Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements… (more)

▼ Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements do not possess convincing scientific merit to advise their use and some even have the potential to cause harm. This is of particular concern for athletes with SCI, who often need to manage secondary health complications for optimal performance. Currently, there is a paucity of research on the supplement knowledge of elite athletes and athletes with SCI, as the majority of research has investigated able-bodied (AB) athletes of junior to university level in countries other than New Zealand (NZ). This emphasises the importance to investigate the supplement knowledge and practices of NZ athletes to evaluate how the SCI population compare with the AB population, and how these groups compare to their overseas counterparts. Methods: The present study investigated the nutritional supplement knowledge, practices and reasons for use of 11 elite AB athletes and 15 athletes with SCI in NZ from an online questionnaire. Results: The SCI and AB groups demonstrated moderate levels of supplement knowledge (64.8% AB vs. 57.5% SCI) (p=0.466). Despite this difference being insignificant, the SCI group reported supplement practices relating to the physiological effects of SCI. Supplement practices may have been used as a prevention method against their increased risk of illness and infection, and potentially as a compensatory strategy to augment an obligatory loss of muscle size and strength. This was shown by their higher prevalence for the use of vitamin C (p=0.05) and creatine (p=0.012), and supported by their nutritional beliefs and reasons for supplement use. Conclusions: Although athletes with SCI have similar levels of supplement knowledge as their AB counterparts, this does not mean their knowledge is adequate. Athletes with SCI appear to be disadvantaged regarding their nutritional education and support, particularly in the present study as the majority of AB athletes attended an elite sporting institute. Moreover, nutrition recommendations for athletes with SCI are non-existent, which emphasizes the need for further research to form the basis of nutritional guidelines for this group. Nevertheless, even with the available nutrition information for AB athletes, it is evident NZ athletes with and without SCI are likely to benefit from further nutrition and supplement education. Advisors/Committee Members: Black, Katherine (advisor).

Subjects/Keywords: supplements; knowledge; spinal; cord; injury; nutrition; athlete

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shaw, D. (2013). Nutritional supplement knowledge of athletes with spinal cord injury . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3795

Chicago Manual of Style (16^th Edition):

Shaw, David. “Nutritional supplement knowledge of athletes with spinal cord injury .” 2013. Masters Thesis, University of Otago. Accessed February 25, 2020. http://hdl.handle.net/10523/3795.

MLA Handbook (7^th Edition):

Shaw, David. “Nutritional supplement knowledge of athletes with spinal cord injury .” 2013. Web. 25 Feb 2020.

Vancouver:

Shaw D. Nutritional supplement knowledge of athletes with spinal cord injury . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10523/3795.

Council of Science Editors:

Shaw D. Nutritional supplement knowledge of athletes with spinal cord injury . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3795

University of Otago

27. Shaw, David Mark. Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3875

► Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements… (more)

▼ Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements do not possess convincing scientific merit to advise their use and some even have the potential to cause harm. This is of particular concern for athletes with SCI, who often need to manage secondary health complications for optimal performance. Currently, there is a paucity of research on the supplement knowledge of elite athletes and athletes with SCI, as the majority of research has investigated able-bodied (AB) athletes of junior to university level in countries other than New Zealand (NZ). This emphasises the importance to investigate the supplement knowledge and practices of NZ athletes to evaluate how the SCI population compare with the AB population, and how these groups compare to their overseas counterparts. Methods: The present study investigated the nutritional supplement knowledge, practices and reasons for use of 11 elite AB athletes and 15 athletes with SCI in NZ from an online questionnaire. Results: The SCI and AB groups demonstrated moderate levels of supplement knowledge (64.8% AB vs. 57.5% SCI) (p=0.466). Despite this difference being insignificant, the SCI group reported supplement practices relating to the physiological effects of SCI. Supplement practices may have been used as a prevention method against their increased risk of illness and infection, and potentially as a compensatory strategy to augment an obligatory loss of muscle size and strength. This was shown by their higher prevalence for the use of vitamin C (p=0.05) and creatine (p=0.012), and supported by their nutritional beliefs and reasons for supplement use. Conclusions: Although athletes with SCI have similar levels of supplement knowledge as their AB counterparts, this does not mean their knowledge is adequate. Athletes with SCI appear to be disadvantaged regarding their nutritional education and support, particularly in the present study as the majority of AB athletes attended an elite sporting institute. Moreover, nutrition recommendations for athletes with SCI are non-existent, which emphasizes the need for further research to form the basis of nutritional guidelines for this group. Nevertheless, even with the available nutrition information for AB athletes, it is evident NZ athletes with and without SCI are likely to benefit from further nutrition and supplement education. Advisors/Committee Members: Black, Katherine (advisor).

Subjects/Keywords: Supplements; Athletes; Practices; Knowledge; Spinal; Cord; Injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shaw, D. M. (2013). Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3875

Chicago Manual of Style (16^th Edition):

Shaw, David Mark. “Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury .” 2013. Masters Thesis, University of Otago. Accessed February 25, 2020. http://hdl.handle.net/10523/3875.

MLA Handbook (7^th Edition):

Shaw, David Mark. “Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury .” 2013. Web. 25 Feb 2020.

Vancouver:

Shaw DM. Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10523/3875.

Council of Science Editors:

Shaw DM. Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3875

Boston University

28. Herman, Paige. Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys.

Degree: MS, Medical Sciences, 2017, Boston University

URL: http://hdl.handle.net/2144/23701

► The lamprey is a basal vertebrate that achieves spontaneous functional recovery after complete spinal cord transection over a stereotypical period of 12 weeks. Despite anatomical,… (more)

Subjects/Keywords: Neurosciences; Lamprey; Regeneration; Spinal cord injury

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herman, P. (2017). Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/23701

Chicago Manual of Style (16^th Edition):

Herman, Paige. “Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys.” 2017. Masters Thesis, Boston University. Accessed February 25, 2020. http://hdl.handle.net/2144/23701.

MLA Handbook (7^th Edition):

Herman, Paige. “Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys.” 2017. Web. 25 Feb 2020.

Vancouver:

Herman P. Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys. [Internet] [Masters thesis]. Boston University; 2017. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/2144/23701.

Council of Science Editors:

Herman P. Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/23701

McMaster University

29. Totosy de Zepetnek, Julia. Cardiovascular health and physical activity among individuals with spinal cord injury.

Degree: PhD, 2014, McMaster University

URL: http://hdl.handle.net/11375/16389

►

An increased prevalence and earlier onset of cardiovascular disease (CVD) occurs in persons with spinal cord injury (SCI); the higher risk may be explained by… (more)

▼

An increased prevalence and earlier onset of cardiovascular disease (CVD) occurs in persons with spinal cord injury (SCI); the higher risk may be explained by novel CVD risk factors of aerobic capacity and peripheral vascular structure and function. Physical inactivity likely contributes to the basis of increased CVD risk after SCI, however evidence on the effectiveness of exercise programs in attenuating CVD risk in SCI is insufficient. The present thesis evaluated novel CVD risk factors in a cohort of individuals with chronic SCI, and examined the effects of a single bout of exercise and exercise training on CVD risk. The first study demonstrated dramatic decreases in body composition, aerobic capacity, and sublesional endothelial function via flow-mediated dilation (FMD) in adults with chronic SCI vs. able-bodied (AB) controls. The second, third, and fourth studies assessed the role of shear rate (SR) patterns on FMD. Elevated retrograde SR had a detrimental effect on brachial and superficial-femoral-artery (SFA) FMD in both SCI and AB, but elevated anterograde SR had a favorable effect on SFA FMD in AB only. The fifth study demonstrated that sublesional vasculature does not respond to a 4-month combination aerobic and resistance-training program using the recently released physical activity guidelines for adults with SCI (PAG). The results of this thesis highlight the multilayered regulation of sublesional vasculature, and that it may respond differently to a single bout of exercise and exercise training when compared to an AB population. This information is crucial when designing strategies to combat impaired vascular structure and function after SCI. The results from this thesis also indicate the potential for the PAG to improve aspects of anthropometrics, body composition, and carotid vascular health in adults with SCI. Further investigations are necessary to delineate the effects of SCI itself, and of exercise, on CVD risk in this population.

Dissertation

Doctor of Science (PhD)

Advisors/Committee Members: MacDonald, Maureen, Kinesiology.

Subjects/Keywords: cardiovascular physiology; spinal cord injury; physical activity

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Totosy de Zepetnek, J. (2014). Cardiovascular health and physical activity among individuals with spinal cord injury. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/16389

Chicago Manual of Style (16^th Edition):

Totosy de Zepetnek, Julia. “Cardiovascular health and physical activity among individuals with spinal cord injury.” 2014. Doctoral Dissertation, McMaster University. Accessed February 25, 2020. http://hdl.handle.net/11375/16389.

MLA Handbook (7^th Edition):

Totosy de Zepetnek, Julia. “Cardiovascular health and physical activity among individuals with spinal cord injury.” 2014. Web. 25 Feb 2020.

Vancouver:

Totosy de Zepetnek J. Cardiovascular health and physical activity among individuals with spinal cord injury. [Internet] [Doctoral dissertation]. McMaster University; 2014. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/11375/16389.

Council of Science Editors:

Totosy de Zepetnek J. Cardiovascular health and physical activity among individuals with spinal cord injury. [Doctoral Dissertation]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16389

California State University – Northridge

30. Azurdia, Daniel. Effects of using virtual reality during exercise on perceptions of pain and fatigue in individuals with spinal cord injury.

Degree: MS, Department of Kinesiology, 2019, California State University – Northridge

URL: http://hdl.handle.net/10211.3/207830

► Pain and fatigue are among the most commonly reported barriers to exercise for individuals with spinal cord injury (SCI). Previous studies have documented virtual reality's… (more)

Subjects/Keywords: spinal cord injury; Dissertations, Academic – CSUN – Kinesiology.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Azurdia, D. (2019). Effects of using virtual reality during exercise on perceptions of pain and fatigue in individuals with spinal cord injury. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/207830

Chicago Manual of Style (16^th Edition):

Azurdia, Daniel. “Effects of using virtual reality during exercise on perceptions of pain and fatigue in individuals with spinal cord injury.” 2019. Masters Thesis, California State University – Northridge. Accessed February 25, 2020. http://hdl.handle.net/10211.3/207830.

MLA Handbook (7^th Edition):

Azurdia, Daniel. “Effects of using virtual reality during exercise on perceptions of pain and fatigue in individuals with spinal cord injury.” 2019. Web. 25 Feb 2020.

Vancouver:

Azurdia D. Effects of using virtual reality during exercise on perceptions of pain and fatigue in individuals with spinal cord injury. [Internet] [Masters thesis]. California State University – Northridge; 2019. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/10211.3/207830.

Council of Science Editors:

Azurdia D. Effects of using virtual reality during exercise on perceptions of pain and fatigue in individuals with spinal cord injury. [Masters Thesis]. California State University – Northridge; 2019. Available from: http://hdl.handle.net/10211.3/207830

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations