subject:(Spinal cord injury)

University of Otago

1. Conway, Trudi May. Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/626

► Outdoor recreation programmes (ORP) have the potential to assist in the rehabilitation and community reintegration process for individuals recovering from spinal cord injury (SCI). Previous… (more)

▼ Outdoor recreation programmes (ORP) have the potential to assist in the rehabilitation and community reintegration process for individuals recovering from spinal cord injury (SCI). Previous evidence provides support for the use of meaningful recreation, leisure activities, and physical exercise in the maintenance of health and development of self-efficacy, peer support and socialisation, thus assisting individuals with SCI to reintegrate back into their communities. However, there are few studies that evaluate the lived experience of individuals with SCI participating in ORPs and the potential benefits of these programmes. A qualitative study using constructivist grounded theory was chosen to gain an understanding of the personal experiences of individuals with SCI who attend these programmes and the influence the programme had on their lives. Eight individuals with SCI who attended an ORP were interviewed twice using semi-structured in-depth interviews. The first interview occurred at the beginning of the ORP and the second interview took place approximately three months following completion of the ORP. Interview data were supplemented by field notes from observation of the participants on the ORPs. From the data collected a model was developed to reflect the key themes and concepts that represented the participants’ experiences and perceptions of attending an ORP. Overall, the participants’ experience was positive. The model depicted three stages in the overall gains made from attending an ORP. These included: immediate benefits, secondary consequences and real life consequences. Three key themes emerged as being the immediate benefits: i) ‘Gaining knowledge and skills’, ii) ‘Learning from peers’ and iii) ‘Pushing boundaries’. These immediate benefits contributed to the secondary consequences: iv) ‘Building confidence’ and v) ‘Self discovery’. The secondary consequences enabled the participant to vi) ‘Get out there’ and participate more following completion of the programme, with increased options in life and therefore to vii) ‘Live and reclaim life’. These latter themes are considered to reflect the real life consequences of attending the ORP. The overall substantive theory that emerged from this study was how attendance at the ORP contributed to the participants with SCI reclaiming and living their lives. The participants indicated they had benefited physically and psychologically from attendance, with the combination of these gains enabling them to engage more actively in social, recreational and vocational pursuits. This resulted in each individual beginning to reclaim or succeeding in reclaiming and living their lives. The participants felt that they now had opportunities and options in their lives. Clinically the data collected in this study and the theory that emerged from the data will enable funders and providers of rehabilitation services to consider ORP as a beneficial adjunct to the rehabilitation and reintegration of individuals with SCI, especially for those individuals who have struggled to… Advisors/Committee Members: Levack, William (advisor).

Subjects/Keywords: Spinal Cord Injury; Outdoor recreation

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APA (6^th Edition):

Conway, T. M. (2011). Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/626

Chicago Manual of Style (16^th Edition):

Conway, Trudi May. “Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes .” 2011. Masters Thesis, University of Otago. Accessed March 02, 2021. http://hdl.handle.net/10523/626.

MLA Handbook (7^th Edition):

Conway, Trudi May. “Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes .” 2011. Web. 02 Mar 2021.

Vancouver:

Conway TM. Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes . [Internet] [Masters thesis]. University of Otago; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10523/626.

Council of Science Editors:

Conway TM. Exploration of the Experiences and Perceptions of Spinal Cord Injured People who attend Outdoor Recreation Programmes . [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/626

University of Ottawa

2. Li, Ruifu. A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair .

Degree: 2014, University of Ottawa

URL: http://hdl.handle.net/10393/31410

► Spinal Cord Injury (SCI) often causes cell death, demyelination, axonal degeneration and cavitation, resulting in functional motor and sensory loss below the site of injury.… (more)

Subjects/Keywords: Hyaluronic acid; Spinal cord injury

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APA (6^th Edition):

Li, R. (2014). A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/31410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Ruifu. “A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair .” 2014. Thesis, University of Ottawa. Accessed March 02, 2021. http://hdl.handle.net/10393/31410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Ruifu. “A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair .” 2014. Web. 02 Mar 2021.

Vancouver:

Li R. A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair . [Internet] [Thesis]. University of Ottawa; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10393/31410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li R. A Novel Thiolated Hyaluronic acid Hydrogel for Spinal Cord Injury Repair . [Thesis]. University of Ottawa; 2014. Available from: http://hdl.handle.net/10393/31410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

3. Santiago-Moreno, Juan G. Effects of Repetitive Acute Intermittent Hypoxia on Lesion Volume following Cervical Spinal Cord Injury.

Degree: MS, Medical Sciences - Medicine, 2018, University of Florida

URL: https://ufdc.ufl.edu/UFE0052360

► Following spinal cord injury (SCI), the lesion progressively increases in size as inflammation and cell death causes axons withdraw from the site of injury. Strategies… (more)

Subjects/Keywords: cord – injury – sci – spinal

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APA (6^th Edition):

Santiago-Moreno, J. G. (2018). Effects of Repetitive Acute Intermittent Hypoxia on Lesion Volume following Cervical Spinal Cord Injury. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0052360

Chicago Manual of Style (16^th Edition):

Santiago-Moreno, Juan G. “Effects of Repetitive Acute Intermittent Hypoxia on Lesion Volume following Cervical Spinal Cord Injury.” 2018. Masters Thesis, University of Florida. Accessed March 02, 2021. https://ufdc.ufl.edu/UFE0052360.

MLA Handbook (7^th Edition):

Santiago-Moreno, Juan G. “Effects of Repetitive Acute Intermittent Hypoxia on Lesion Volume following Cervical Spinal Cord Injury.” 2018. Web. 02 Mar 2021.

Vancouver:

Santiago-Moreno JG. Effects of Repetitive Acute Intermittent Hypoxia on Lesion Volume following Cervical Spinal Cord Injury. [Internet] [Masters thesis]. University of Florida; 2018. [cited 2021 Mar 02]. Available from: https://ufdc.ufl.edu/UFE0052360.

Council of Science Editors:

Santiago-Moreno JG. Effects of Repetitive Acute Intermittent Hypoxia on Lesion Volume following Cervical Spinal Cord Injury. [Masters Thesis]. University of Florida; 2018. Available from: https://ufdc.ufl.edu/UFE0052360

University of Toronto

4. Wilson, Jefferson. Prediction of Patient Outcomes after Traumatic Spinal Cord Injury using Acute Clinical and Radiological Variables.

Degree: 2013, University of Toronto

URL: http://hdl.handle.net/1807/68910

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There is a pressing unmet need, in the acute setting after traumatic spinal cord injury (SCI), to predict both short and long-term clinical outcomes for… (more)

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There is a pressing unmet need, in the acute setting after traumatic spinal cord injury (SCI), to predict both short and long-term clinical outcomes for individuals affected. Possessing this ability would not only facilitate improved communication and treatment planning in the clinical realm, but also would allow for enhanced study of SCI patients in the research realm. Presently, there is little available to scientifically guide clinicians and researchers alike with respect to this topic. In this thesis, it is hypothesized that clinical outcomes can accurately be predicted after SCI based on acute patient, injury and radiological features. In order to investigate this hypothesis, a series of investigations have been undertaken, using a combination of two large prospective SCI datasets, to explore the impact of acute clinical and radiological factors on long-term functional outcome, long-term neurological outcome and in-hospital complication occurrence. First, after performing a comprehensive systematic review of existing literature, a clinico-radiographic model was created and internally validated using a combination of pre-specified clinical and magnetic resonance imaging (MRI) variables obtained in the first 3 days after injury, to predict functional outcome at 1 year. Second, the acute radiological finding of facet dislocation (FD) was evaluated and found to predict reduced motor neurological recovery at 1 year, even after adjusting for individuals’ baseline degree of injury severity. Third, a combination of clinical variables predicting in-hospital complication development after cervical SCI were identified and used to develop a model to predict the occurrence of these complication events. Finally, the impact of age as an effect modifier governing the relationship between acute neurologic status and long-term functional outcome was evaluated. This analysis demonstrated older age to have the greatest negative impact on functional outcome in patients with lesions of intermediate severity. Although future validation studies are required, the findings presented in this thesis have provided new insights into relationships between acute predictor and outcome variables in the context of traumatic SCI. Further, these analyses have demonstrated the feasibility, and potential advantages, of using a combination of acute clinical and radiological variables, to predict outcome after SCI.

PhD

Advisors/Committee Members: Fehlings, Michael, Medical Science.

Subjects/Keywords: Spinal Cord Injury; Prediction; 0564

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APA (6^th Edition):

Wilson, J. (2013). Prediction of Patient Outcomes after Traumatic Spinal Cord Injury using Acute Clinical and Radiological Variables. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/68910

Chicago Manual of Style (16^th Edition):

Wilson, Jefferson. “Prediction of Patient Outcomes after Traumatic Spinal Cord Injury using Acute Clinical and Radiological Variables.” 2013. Doctoral Dissertation, University of Toronto. Accessed March 02, 2021. http://hdl.handle.net/1807/68910.

MLA Handbook (7^th Edition):

Wilson, Jefferson. “Prediction of Patient Outcomes after Traumatic Spinal Cord Injury using Acute Clinical and Radiological Variables.” 2013. Web. 02 Mar 2021.

Vancouver:

Wilson J. Prediction of Patient Outcomes after Traumatic Spinal Cord Injury using Acute Clinical and Radiological Variables. [Internet] [Doctoral dissertation]. University of Toronto; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1807/68910.

Council of Science Editors:

Wilson J. Prediction of Patient Outcomes after Traumatic Spinal Cord Injury using Acute Clinical and Radiological Variables. [Doctoral Dissertation]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/68910

University of Sydney

5. Conroy, James Peter. Starting again: making art after a spinal cord injury .

Degree: 2014, University of Sydney

URL: http://hdl.handle.net/2123/13359

► This thesis explores how one's art practice changes after suffering a spinal cord injury. Throughout this MFA I document how my art practice changed after… (more)

Subjects/Keywords: Painting; Spinal cord injury

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APA (6^th Edition):

Conroy, J. P. (2014). Starting again: making art after a spinal cord injury . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/13359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Conroy, James Peter. “Starting again: making art after a spinal cord injury .” 2014. Thesis, University of Sydney. Accessed March 02, 2021. http://hdl.handle.net/2123/13359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Conroy, James Peter. “Starting again: making art after a spinal cord injury .” 2014. Web. 02 Mar 2021.

Vancouver:

Conroy JP. Starting again: making art after a spinal cord injury . [Internet] [Thesis]. University of Sydney; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2123/13359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Conroy JP. Starting again: making art after a spinal cord injury . [Thesis]. University of Sydney; 2014. Available from: http://hdl.handle.net/2123/13359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

6. van Wyk, Vania. Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa .

Degree: 2018, University of the Western Cape

URL: http://hdl.handle.net/11394/6873

► The distressing event of Spinal Cord Injury (SCI) leads to complete or incomplete injury, and results in many complications such as such as neurogenic shock,… (more)

Subjects/Keywords: Spinal cord injury; Trauma; Participation; Traumatic spinal cord injury; Rehabilitation

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APA (6^th Edition):

van Wyk, V. (2018). Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

van Wyk, Vania. “Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa .” 2018. Thesis, University of the Western Cape. Accessed March 02, 2021. http://hdl.handle.net/11394/6873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

van Wyk, Vania. “Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa .” 2018. Web. 02 Mar 2021.

Vancouver:

van Wyk V. Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa . [Internet] [Thesis]. University of the Western Cape; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11394/6873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

van Wyk V. Activity limitations and participation restrictions four years after traumatic spinal cord injury in Cape Town, South Africa . [Thesis]. University of the Western Cape; 2018. Available from: http://hdl.handle.net/11394/6873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

7. Meisner, Jason George. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.

Degree: PhD, Department of Anatomy & Neurobiolgy with Neuroscience, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/14411

► Neuropathic pain is a significant and frequent outcome of spinal cord injury (SCI), and is often refractory to treatment. A better understanding of the pathological… (more)

▼ Neuropathic pain is a significant and frequent outcome of spinal cord injury (SCI), and is often refractory to treatment. A better understanding of the pathological processes following injury that contribute to the development of neuropathic pain will aid the search for novel therapeutics. In the second chapter of this thesis a murine model of post-SCI below-lesion neuropathic pain was utilized to investigate changes in GABAergic tone. The gad1:GFP transgenic mouse line allowed the study of a subpopulation of GFPlabeled GABAergic neurons under control of the GABA synthesizing glutamate decarboxylase enzyme. SCI was observed to result in a loss of GABAergic neurons, and secondary markers of GABAergic tone supported this observation. This finding suggests that GABAergic interneuron cell death accounts for the decreased GABAergic tone previously reported post-SCI. In the third chapter of this thesis it was attempted to prevent the death of GABAergic neurons post-SCI using a transgenic mouse line expressing increased levels of the X-linked inhibitor of apoptosis (XIAP) under the ubiquitin C promoter. No differences were observed between ubXIAP and wildtype mice, indicating that increased expression of XIAP is not sufficient to prevent the development of neuropathic pain post- SCI. The fourth chapter of this thesis attempted to prevent the development of neuropathic pain through a novel treatment schedule of the drug pregabalin. Pregabalin administered shortly after SCI prevented the development of neuropathic pain. Pregabalin initiated 1 week post-SCI had no effect. Early pregabalin treatment did not appear to dramatically alter glial activation, or expression of the pregabalin receptor, but we observed changes in markers associated with synaptic plasticity. My findings build upon our knowledge of the mechanisms underlying post-SCI below-lesion neuropathic pain, and suggest new avenues of research, such as the uses of preemptive treatment with pregabalin, that offer promise for translation to clinical use. Advisors/Committee Members: Claire Hulsebosch (external-examiner), Kazue Semba (graduate-coordinator), William Baldridge (thesis-reader), Ronald Leslie (thesis-reader), Stefan Kruger (thesis-reader), Daniel Marsh (thesis-supervisor), Received (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: SPINAL CORD INJURY; PAIN; GABA; PREGABALIN

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meisner, J. G. (2012). POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14411

Chicago Manual of Style (16^th Edition):

Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Doctoral Dissertation, Dalhousie University. Accessed March 02, 2021. http://hdl.handle.net/10222/14411.

MLA Handbook (7^th Edition):

Meisner, Jason George. “POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES.” 2012. Web. 02 Mar 2021.

Vancouver:

Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Internet] [Doctoral dissertation]. Dalhousie University; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10222/14411.

Council of Science Editors:

Meisner JG. POST-SPINAL CORD INJURY BELOW-LESION NEUROPATHIC PAIN: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES. [Doctoral Dissertation]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/14411

8. Chinthu, Romeo. Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats.

Degree: Biotechnology, 2012, Cochin University of Science and Technology

URL: http://dyuthi.cusat.ac.in/purl/3046

►

The present study deals with the Cholinergic Receptor subtypes functional regulation in spinal cord injured monoplegic rats: Effect of 5-HT GABA and bone marrow cells.Spinal… (more)

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The present study deals with the Cholinergic Receptor subtypes functional regulation in spinal cord injured monoplegic rats: Effect of 5-HT GABA and bone marrow cells.Spinal cord injury causes permanent and irrevocable motor deficits and neurodegeneration. Disruption of the spinal cord leads to diminished transmission of descending control from the brain to motor neurons and ascending sensory information. Behavioural studies showed deficits in motor control and coordination in SCI rats. Cholinergic system plays an important role in SCI, the evaluation of which provides valuable insight on the underlying mechanisms of motor deficit that occur during SCI. The cholinergic transmission was studied by assessing the muscarinic and nicotinic receptors; cholinergic enzymes- ChAT and AChE; second messenger enzyme PLC; transcription factor CREB and second messengers - IP3, cAMP and cGMP. We observed a decrease in the cholinergic transmission in the brain and spinal cord of SCI rats. The disrupted cholinergic system is the indicative of motor deficit and neuronal degeneration in the spinal cord and brain regions. SCI mediated oxidative stress and apoptosis leads to neuronal degeneration in SCI rats. The decreased expression of anti oxidant enzymes – SOD, GPx and neuronal cell survival factors - BDNF, GDNF, IGF-1, Akt and cyclin D2 along with increased expression of apoptotic factors – Bax, caspase-8, TNFa and NF-kB augmented the neuronal degeneration in SCI condition. BMC administration in combination with 5-HT and GABA in SCI rats showed a reversal in the impaired cholinergic neurotransmission and reduced the oxidative stress and apoptosis. It also enhanced the expression of cell survival factors in the spinal cord region. In SCI rats treated with 5-HT and GABA, the transplanted BMC expressed NeuN confirming that 5-HT and GABA induced the differentiation and proliferation of BMC to neurons in the spinal cord. Neurotrophic factors and anti-apoptotic elements in SCI rats treated with 5-HT and GABA along with BMC rendered neuroprotective effects accompanied by improvement in behavioural deficits. This resulted in a significant reversal of altered cholinergic neurotransmission in SCI. The restorative and neuro protective effects of BMC in combination with 5-HT and GABA are of immense therapeutic significance in the clinical management of SCI.

Cochin University of Science and Technology

Subjects/Keywords: Spinal cord injury(SCI); Current treatments and its side effects in spinal cord injury; Acetylcholine; Neuronal survival factors in spinal cord injury; Cell therapy in SCI; Apoptosis &Spinal cord Injury

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APA (6^th Edition):

Chinthu, R. (2012). Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/3046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chinthu, Romeo. “Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats.” 2012. Thesis, Cochin University of Science and Technology. Accessed March 02, 2021. http://dyuthi.cusat.ac.in/purl/3046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chinthu, Romeo. “Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats.” 2012. Web. 02 Mar 2021.

Vancouver:

Chinthu R. Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats. [Internet] [Thesis]. Cochin University of Science and Technology; 2012. [cited 2021 Mar 02]. Available from: http://dyuthi.cusat.ac.in/purl/3046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chinthu R. Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats. [Thesis]. Cochin University of Science and Technology; 2012. Available from: http://dyuthi.cusat.ac.in/purl/3046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – San Diego

9. Corleto, Jose Alfredo. Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat.

Degree: Biomedical Sciences, 2016, University of California – San Diego

URL: http://www.escholarship.org/uc/item/64h01790

► Spinal cord injury is a problem that carries with it many implications including changes in motor circuit action that then lead to development of muscle… (more)

▼ Spinal cord injury is a problem that carries with it many implications including changes in motor circuit action that then lead to development of muscle spasticity, hyperreflexia, and loss of inhibitory response stemming from injury. These changes contribute to muscle spasms elicited by casual stimulation of afferent fibers that then lead to changes in muscle action and to a decrease in the quality of life. Here, we developed a thoracic 9 spinal cord transection injury model in Sprague-Dawley rats to study the changes in motor circuitry in these paraplegic rats. For the first part of my thesis work, we used electrophysiology in this SCI model to study the development of gastrocnemius muscle spasticity, and also the presence of electrical stimulation- and tactile-evoked hyperreflexia at chronic phase following injury. The second part of my thesis focused on the use of clinical pharmacology (Baclofen, GABAb agonist and Tizanidine, α2 adrenergic agonist) and non-used avenues (NGX424, ampa/kainate antagonist) to look at the amelioration of spasticity and spinal hyper-reflexia. The third part of my thesis was aimed at using experimental gene therapy and to test the effect of spinal GAD65 gene upregulation (as achieved by spinal IT or SP AAV9-GAD65 delivery) on chronic spasticity.Our results are sequentially organized as follows: 1) Characterization of time-dependent appearance of muscle spasticity and spinal hyper-reflexia after spinal Th9 transection in rat as defined by i) ankle-rotation evoked increase in muscle resistance, ii) tactile stimulus-evoked EMG response, and iii) electrical stimulus (H-reflex) defined muscle hyper-reflexia. 2) Characterization of anti-spastic potency of clinically validated anti-spastic agents in rat Th 9 spinal transection-induced chronic spasticity model. 3) Effect of spinal GAD65 gene upregulation in combination with systemic tiagabine (GABA uptake inhibitor) treatment on chronic muscle spasticity. In conclusion, my work has demonstrated that our T9 TSCT model can recapitulate several pathologic neurological phenotypes (muscle spasticity, spinal hyper-reflexia) seen in human patients suffering from chronic spinal cord injury. Chronic muscle spasticity measured in the rat model is effectively suppressed by clinically validated anti-spastic agents, which suggests that this model represents an appropriate avenue for development of new anti-spastic therapies.

Subjects/Keywords: Biology; Gene Therapy; Pharmacology; Spinal Cord Injury

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APA (6^th Edition):

Corleto, J. A. (2016). Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/64h01790

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Corleto, Jose Alfredo. “Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat.” 2016. Thesis, University of California – San Diego. Accessed March 02, 2021. http://www.escholarship.org/uc/item/64h01790.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Corleto, Jose Alfredo. “Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat.” 2016. Web. 02 Mar 2021.

Vancouver:

Corleto JA. Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat. [Internet] [Thesis]. University of California – San Diego; 2016. [cited 2021 Mar 02]. Available from: http://www.escholarship.org/uc/item/64h01790.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Corleto JA. Electrophysiological and neurological characterization of a thoracic 9 model of spinal cord injury-induced muscle spasticity and the therapeutic anti-spastic effect following spinal GAD65 gene delivery in the rat. [Thesis]. University of California – San Diego; 2016. Available from: http://www.escholarship.org/uc/item/64h01790

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

10. Krajacic, Aleksandra. Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat.

Degree: PhD, Centre for Neuroscience, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/r207tq51t

► Injury to the cervical spinal cord is a devastating event that results in a transient to permanent loss of sensory and motor functions following injury.… (more)

▼ Injury to the cervical spinal cord is a devastating event that results in a transient to permanent loss of sensory and motor functions following injury. Moderate recovery has been reported to occur in individuals and in animal models after spinal cord injury (SCI). One approach to promote recovery after SCI is rehabilitative training. This thesis examines the relation of reaching training with adaptive changes (i.e. plasticity) and functional recovery following SCI. In my first experiment, I investigated whether plasticity of the corticospinal tract (CST) is the cause for reaching recovery after ablation of the dorsal and lateral CST. Rats that received reaching training were significantly better in reaching than their untrained counterparts. A relesion of the CST revealed that the reaching recovery mainly depended on plasticity of the CST itself. Since it is controversial whether training should be initiated immediately after SCI, I investigated whether a delayed initiation of reaching training after SCI is beneficial. I compared the reaching success of rats that received reaching training on day 4 post SCI with rats that received training on day 12 post SCI. I found that the reaching success in rats that either received reaching training on day 4 or 12 following SCI was similar. Lastly, I investigated whether training efficacy is declined in chronically injured rats. Since it has been shown that the inflammatory response after SCI declines, it is questionable whether there is a relation between the inflammatory response after SCI and training efficacy. In my last experiment I injected chronically injured rats with a substance that induces a systemic inflammation. I found that rehabilitative reaching training in chronic injured rats only resulted in an improved reaching recovery when the training was combined with the administration of the substance that induces inflammation (lipopolysaccharide). Although there are still unanswered questions regarding the underlying mechanism for functional recovery after SCI, the results of this thesis could be used as a basic to improve future rehabilitative training strategies and therefore improve the quality of life in individuals that suffer from SCI.

Subjects/Keywords: reaching; corticospinal; spinal cord injury; lipopolysaccharide

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APA (6^th Edition):

Krajacic, A. (2011). Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/r207tq51t

Chicago Manual of Style (16^th Edition):

Krajacic, Aleksandra. “Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat.” 2011. Doctoral Dissertation, University of Alberta. Accessed March 02, 2021. https://era.library.ualberta.ca/files/r207tq51t.

MLA Handbook (7^th Edition):

Krajacic, Aleksandra. “Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat.” 2011. Web. 02 Mar 2021.

Vancouver:

Krajacic A. Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Mar 02]. Available from: https://era.library.ualberta.ca/files/r207tq51t.

Council of Science Editors:

Krajacic A. Rehabilitative reaching training and plasticity following spinal cord injury in the adult rat. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/r207tq51t

University of Saskatchewan

11. Hassan, Atiq. Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury.

Degree: 2015, University of Saskatchewan

URL: http://hdl.handle.net/10388/ETD-2015-09-2235

► Many experimental therapies have been used in the search for effective approaches to improve recovery after spinal cord injury (SCI). One of the most promising… (more)

▼ Many experimental therapies have been used in the search for effective approaches to improve recovery after spinal cord injury (SCI). One of the most promising approaches is the augmentation of spontaneously occurring plasticity in uninjured neural pathways. Acute intermittent hypoxia (AIH-brief exposures to reduced O2 levels alternating with normal O2 levels) elicits plasticity in respiratory and non-respiratory spinal systems in experimental animals. AIH treatment has also been shown to improve walking abilities in persons with chronic incomplete SCI. In this thesis, I first examined the effect of AIH treatment, alone or in combination with motor training, on functional recovery in a rat model of incomplete cervical SCI. Second, I examined the effect of AIH on the expression of plasticity- and hypoxia-related proteins in the spinal cords of SCI rats. In a randomized, blinded, normoxia-controlled study, rats were trained to cross a horizontal ladder and footslip errors were measured before surgery for SCI, 4 wks post-surgery, each day of daily AIH treatment, and 1, 2, 4 and 8 weeks after treatment. dAIH treatment consisted of 10 episodes of AIH: (5 min 11% O2: 5 min 21% O2) for 7 days beginning at 4 wks post-SCI. AIH-treated rats made fewer footslips on the ladder task compared to normoxia-treated control rats after 4 days of treatment and this improvement was sustained for 8 wks post-treatment. Importantly, daily ladder training was required for AIH treatment to facilitate recovery. AIH treatment + motor training also increased the expression of Hypoxia-inducible factor-1α (HIF-1α), Vascular endothelial growth factor (VEGF), Brain-derived neurotrophic factor (BDNF), tyrosine kinase B receptors (trkB) and phospho-trkB in spinal motor neurons in SCI rats compared to normoxia-treated SCI rats. In particular these hypoxia- and plasticity-related proteins were differentially expressed both temporally and spatially in the spinal cord during AIH treatment. These findings demonstrate that AIH + motor training can augment neural plasticity and improve motor recovery in an animal model of SCI. Taken together with the promising findings from human SCI studies, the results of this thesis suggest that AIH has potential as an effective therapy to restore motor function after nervous system injury. Advisors/Committee Members: Muir, Gillian D., Machin, Karen, Weber, Lynn, Verge, Valerie, Paterson, Phyllis.

Subjects/Keywords: Intermittent hypoxia; Plasticity; Spinal cord injury

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APA (6^th Edition):

Hassan, A. (2015). Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2015-09-2235

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hassan, Atiq. “Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury.” 2015. Thesis, University of Saskatchewan. Accessed March 02, 2021. http://hdl.handle.net/10388/ETD-2015-09-2235.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hassan, Atiq. “Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury.” 2015. Web. 02 Mar 2021.

Vancouver:

Hassan A. Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury. [Internet] [Thesis]. University of Saskatchewan; 2015. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10388/ETD-2015-09-2235.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hassan A. Intermittent hypoxia induces spinal plasticity in rats with cervical spinal cord injury. [Thesis]. University of Saskatchewan; 2015. Available from: http://hdl.handle.net/10388/ETD-2015-09-2235

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

12. Woller, Sarah Ann. Characterization of Morphine Self-Administration Following Spinal Cord Injury.

Degree: PhD, Neuroscience, 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151129

► Approximately two-thirds of patients will experience pain following spinal cord injury (SCI). This pain can arise as an immediate consequence of SCI, or can develop… (more)

▼ Approximately two-thirds of patients will experience pain following spinal cord injury (SCI). This pain can arise as an immediate consequence of SCI, or can develop over time into chronic, neuropathic pain. Individuals are frequently prescribed opioid analgesics, including morphine, for the treatment of pain in both the acute and chronic phases of SCI. Yet, despite the prevalence of opioid use, no studies have examined the addictive potential of opioids, or their secondary effects, following spinal injury. These experiments used a clinically relevant self-administration paradigm to examine both addiction and functional recovery after morphine administration. To assess morphine administration in the acute phase of SCI, animals were placed in operant chambers 24-hours following spinal injury. In the chambers, depression of a reinforced lever resulted in an intravenous infusion of morphine (or vehicle). Animals were placed in the chambers for 7, 12-hour sessions and could administer up to 30 mg of morphine per session. Morphine self-administration was also examined in the chronic phase of injury. Animals were placed into operant chambers for 7, 12-hour sessions beginning 14 or 35 days after injury. The amount of morphine administered, as well as recovery of locomotor function and general health, was compared across subjects with SCI and sham (no injury) controls. In the acute phase of injury, SCI significantly reduced self-administration of morphine, but administration led to decreased recovery of locomotor function and weight loss. In the chronic phase of injury, self-administration did not differ between contused and sham animals. All subjects administered the full amount of morphine available each day. In this phase of injury, morphine administration led to significant weight loss, but did not attenuate recovery of locomotor function. These studies suggest that spinal injury reduced the addictive potential of morphine in the acute, but not the chronic, phase of SCI. However, acute administration of high doses of morphine decreased recovery of locomotor function. Morphine should not be used in this phase of injury for the clinical treatment of pain. In the chronic phase, opioid use must be closely monitored as use may result in addictive behavior. Advisors/Committee Members: Hook, Michelle A (advisor), Grau, James W (committee member), Miranda, Rajesh (committee member), Li, Jianrong (committee member).

Subjects/Keywords: spinal cord injury; morphine; self-administration

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APA (6^th Edition):

Woller, S. A. (2013). Characterization of Morphine Self-Administration Following Spinal Cord Injury. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151129

Chicago Manual of Style (16^th Edition):

Woller, Sarah Ann. “Characterization of Morphine Self-Administration Following Spinal Cord Injury.” 2013. Doctoral Dissertation, Texas A&M University. Accessed March 02, 2021. http://hdl.handle.net/1969.1/151129.

MLA Handbook (7^th Edition):

Woller, Sarah Ann. “Characterization of Morphine Self-Administration Following Spinal Cord Injury.” 2013. Web. 02 Mar 2021.

Vancouver:

Woller SA. Characterization of Morphine Self-Administration Following Spinal Cord Injury. [Internet] [Doctoral dissertation]. Texas A&M University; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1969.1/151129.

Council of Science Editors:

Woller SA. Characterization of Morphine Self-Administration Following Spinal Cord Injury. [Doctoral Dissertation]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151129

Texas A&M University

13. Turtle, Joel Dylan. Acute Pain after Spinal Cord Injury: Impaired Recovery through Inflammation, Cell Death, and Hemorrhage.

Degree: PhD, Neuroscience, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/173285

► Over 90% of spinal cord injuries are caused by traumatic accidents and are often associated with secondary tissue damage that can provide a source of… (more)

Subjects/Keywords: spinal cord injury; multitrauma; pain; cell death

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APA (6^th Edition):

Turtle, J. D. (2018). Acute Pain after Spinal Cord Injury: Impaired Recovery through Inflammation, Cell Death, and Hemorrhage. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173285

Chicago Manual of Style (16^th Edition):

Turtle, Joel Dylan. “Acute Pain after Spinal Cord Injury: Impaired Recovery through Inflammation, Cell Death, and Hemorrhage.” 2018. Doctoral Dissertation, Texas A&M University. Accessed March 02, 2021. http://hdl.handle.net/1969.1/173285.

MLA Handbook (7^th Edition):

Turtle, Joel Dylan. “Acute Pain after Spinal Cord Injury: Impaired Recovery through Inflammation, Cell Death, and Hemorrhage.” 2018. Web. 02 Mar 2021.

Vancouver:

Turtle JD. Acute Pain after Spinal Cord Injury: Impaired Recovery through Inflammation, Cell Death, and Hemorrhage. [Internet] [Doctoral dissertation]. Texas A&M University; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1969.1/173285.

Council of Science Editors:

Turtle JD. Acute Pain after Spinal Cord Injury: Impaired Recovery through Inflammation, Cell Death, and Hemorrhage. [Doctoral Dissertation]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/173285

Texas A&M University

14. Erosa, Norma. Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury.

Degree: PhD, Counseling Psychology, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587

► This dissertation presents the prediction of quality of life (QoL), composed of by life satisfaction and self-perceived health status, across 5 years post a spinal… (more)

▼ This dissertation presents the prediction of quality of life (QoL), composed of by life satisfaction and self-perceived health status, across 5 years post a spinal cord injury (SCI) hospital discharge. Predictor variables of functional independence, pain, and family satisfaction, as mediated by environmental accessibility are examined. Environmental accessibility is conceptualized as being composed of mobility and social integration. Data are a subset from a longitudinal study of adjustment following disability. Two models were examined in order to predict QoL, Model 1 (Life Satisfaction) and Model 2 (Self-Perceived Health Status). Results from this study were obtained by testing models using path modeling. Evaluation indices suggest good to adequate model fit, CFI, RMSEA, and SRMR for Model 1 and Model 2. In Model 1, results indicated that mobility and social integration, components of environmental accessibility, mediated the relationship between functional independence and life satisfaction (beta = 0.243, p = 0.009 and beta = 0.120, p = 0.038, respectively). In Model 2, the component of mobility of environmental accessibility mediated the relationship between functional independence and self-perceived health status (beta = 0.288, p = 0.002). Results indicate that access to the environment is an important predictor of life satisfaction and perceived health status five years after medical discharge for a traumatically-acquired SCI. These factors of environmental access ? mobility and social integration ? appear to be more important determinants of quality of life post-SCI than functional impairment or the presence of pain. Programs that enhance mobility and social integration following return to the community following SCI may be indicated. Furthermore, given that the construct of environmental accessibility is relatively new, studies that examine this construct are needed in order to better understand how it is best conceptualized. Advisors/Committee Members: Elliott, Timothy R. (advisor), Brossart, Daniel (committee member), Rae, William (committee member), Burdine, James (committee member).

Subjects/Keywords: Spinal Cord Injury; Quality of Life

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APA (6^th Edition):

Erosa, N. (2012). Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587

Chicago Manual of Style (16^th Edition):

Erosa, Norma. “Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury.” 2012. Doctoral Dissertation, Texas A&M University. Accessed March 02, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587.

MLA Handbook (7^th Edition):

Erosa, Norma. “Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury.” 2012. Web. 02 Mar 2021.

Vancouver:

Erosa N. Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury. [Internet] [Doctoral dissertation]. Texas A&M University; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587.

Council of Science Editors:

Erosa N. Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury. [Doctoral Dissertation]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11587

McMaster University

15. Piran, Siavash. THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY.

Degree: MSc, 2018, McMaster University

URL: http://hdl.handle.net/11375/24093

►

Patients with acute spinal cord injury (SCI) have a high risk of venous thromboembolism (VTE) despite receiving thromboprophylaxis. The current standard of care recommended by… (more)

▼

Patients with acute spinal cord injury (SCI) have a high risk of venous thromboembolism (VTE) despite receiving thromboprophylaxis. The current standard of care recommended by guidelines is to use low-molecular-weight heparin (LMWH) for thromboprophylaxis for 90 days. This entails once- or twice-daily subcutaneous injections of LMWH for this duration, which is inconvenient for the patients and only partially effective. There are uncertainties about risk factors and the true incidence of SCI-associated VTE, the optimal time to commence thromboprophylaxis, and the optimal duration of thromboprophylaxis. Furthermore, there are currently no studies on the use of direct oral anticoagulants (DOACs) for thromboprophylaxis in patients with SCI. The use of DOACs for prophylaxis in this group can eliminate the inconvenience associated with daily subcutaneous injections for 3 months. To examine the incidence and risk factors of SCI-associated VTE, we performed a retrospective chart review of consecutive adult patients with acute SCI admitted to Hamilton General hospital from 2009 to 2015. The incidence of symptomatic VTE despite the use of thromboprophylaxis was 11% within 90 days of acute SCI; age and presence of other sites of injuries (such as lower limb fractures or pelvic fractures) along with SCI were independent risk factors for symptomatic VTE. To determine the opinion of Canadian spine surgeons about the optimal timing of starting LMWH after acute SCI, a short 5-question electronic survey was sent to the Canadian Spine Society. Data from our survey showed that the understanding about thromboprophylaxis after acute SCI was variable and that most spine surgeons were comfortable with starting LMWH after consultation with the surgeon. Future studies should focus on educational strategies to improve the knowledge base in this area. We will perform a pilot study at the Hamilton General Hospital comparing apixaban versus LMWH for thromboprophylaxis in patients with acute SCI. The use of apixaban for this indication can contribute to cost savings for the healthcare system and increased convenience for the patient. The protocol for the pilot study as well as steps towards a multi-center randomized controlled trial will be detailed in this thesis.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Schulman, Sam, Health Research Methodology.

Subjects/Keywords: Thromboprophylaxis; Spinal Cord Injury; Pilot Study

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APA (6^th Edition):

Piran, S. (2018). THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24093

Chicago Manual of Style (16^th Edition):

Piran, Siavash. “THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY.” 2018. Masters Thesis, McMaster University. Accessed March 02, 2021. http://hdl.handle.net/11375/24093.

MLA Handbook (7^th Edition):

Piran, Siavash. “THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY.” 2018. Web. 02 Mar 2021.

Vancouver:

Piran S. THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY. [Internet] [Masters thesis]. McMaster University; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11375/24093.

Council of Science Editors:

Piran S. THROMBOPROPHYLAXIS IN PATIENTS WITH ACUTE SPINAL CORD INJURY. [Masters Thesis]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/24093

McMaster University

16. Totosy de Zepetnek, Julia. Cardiovascular health and physical activity among individuals with spinal cord injury.

Degree: PhD, 2014, McMaster University

URL: http://hdl.handle.net/11375/16389

►

An increased prevalence and earlier onset of cardiovascular disease (CVD) occurs in persons with spinal cord injury (SCI); the higher risk may be explained by… (more)

▼

An increased prevalence and earlier onset of cardiovascular disease (CVD) occurs in persons with spinal cord injury (SCI); the higher risk may be explained by novel CVD risk factors of aerobic capacity and peripheral vascular structure and function. Physical inactivity likely contributes to the basis of increased CVD risk after SCI, however evidence on the effectiveness of exercise programs in attenuating CVD risk in SCI is insufficient. The present thesis evaluated novel CVD risk factors in a cohort of individuals with chronic SCI, and examined the effects of a single bout of exercise and exercise training on CVD risk. The first study demonstrated dramatic decreases in body composition, aerobic capacity, and sublesional endothelial function via flow-mediated dilation (FMD) in adults with chronic SCI vs. able-bodied (AB) controls. The second, third, and fourth studies assessed the role of shear rate (SR) patterns on FMD. Elevated retrograde SR had a detrimental effect on brachial and superficial-femoral-artery (SFA) FMD in both SCI and AB, but elevated anterograde SR had a favorable effect on SFA FMD in AB only. The fifth study demonstrated that sublesional vasculature does not respond to a 4-month combination aerobic and resistance-training program using the recently released physical activity guidelines for adults with SCI (PAG). The results of this thesis highlight the multilayered regulation of sublesional vasculature, and that it may respond differently to a single bout of exercise and exercise training when compared to an AB population. This information is crucial when designing strategies to combat impaired vascular structure and function after SCI. The results from this thesis also indicate the potential for the PAG to improve aspects of anthropometrics, body composition, and carotid vascular health in adults with SCI. Further investigations are necessary to delineate the effects of SCI itself, and of exercise, on CVD risk in this population.

Dissertation

Doctor of Science (PhD)

Advisors/Committee Members: MacDonald, Maureen, Kinesiology.

Subjects/Keywords: cardiovascular physiology; spinal cord injury; physical activity

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APA (6^th Edition):

Totosy de Zepetnek, J. (2014). Cardiovascular health and physical activity among individuals with spinal cord injury. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/16389

Chicago Manual of Style (16^th Edition):

Totosy de Zepetnek, Julia. “Cardiovascular health and physical activity among individuals with spinal cord injury.” 2014. Doctoral Dissertation, McMaster University. Accessed March 02, 2021. http://hdl.handle.net/11375/16389.

MLA Handbook (7^th Edition):

Totosy de Zepetnek, Julia. “Cardiovascular health and physical activity among individuals with spinal cord injury.” 2014. Web. 02 Mar 2021.

Vancouver:

Totosy de Zepetnek J. Cardiovascular health and physical activity among individuals with spinal cord injury. [Internet] [Doctoral dissertation]. McMaster University; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11375/16389.

Council of Science Editors:

Totosy de Zepetnek J. Cardiovascular health and physical activity among individuals with spinal cord injury. [Doctoral Dissertation]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16389

University of Newcastle

17. Flynn, Jamie R. Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons.

Degree: PhD, 2015, University of Newcastle

URL: http://hdl.handle.net/1959.13/1296580

►

Research Doctorate - Doctor of Philopsophy (PhD)

The work presented in this thesis had two major aims. The first was to develop an in vitro… (more)

Subjects/Keywords: spinal cord injury; electrophysiology; propriospinal; interneuron

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APA (6^th Edition):

Flynn, J. R. (2015). Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1296580

Chicago Manual of Style (16^th Edition):

Flynn, Jamie R. “Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons.” 2015. Doctoral Dissertation, University of Newcastle. Accessed March 02, 2021. http://hdl.handle.net/1959.13/1296580.

MLA Handbook (7^th Edition):

Flynn, Jamie R. “Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons.” 2015. Web. 02 Mar 2021.

Vancouver:

Flynn JR. Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1959.13/1296580.

Council of Science Editors:

Flynn JR. Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1296580

Universiteit Utrecht

18. Sagel, D.C. Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/321298

► Rationale: A new instrument for emergency medical services has been developed to detect symptoms of spinal cord injury and enables patients to receive appropriate care… (more)

Subjects/Keywords: EMS; Spinal cord injury; Emergency medicine; implementation.

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APA (6^th Edition):

Sagel, D. C. (2015). Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/321298

Chicago Manual of Style (16^th Edition):

Sagel, D C. “Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study.” 2015. Masters Thesis, Universiteit Utrecht. Accessed March 02, 2021. http://dspace.library.uu.nl:8080/handle/1874/321298.

MLA Handbook (7^th Edition):

Sagel, D C. “Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study.” 2015. Web. 02 Mar 2021.

Vancouver:

Sagel DC. Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study. [Internet] [Masters thesis]. Universiteit Utrecht; 2015. [cited 2021 Mar 02]. Available from: http://dspace.library.uu.nl:8080/handle/1874/321298.

Council of Science Editors:

Sagel DC. Classifying symptoms of traumatic spinal cord injury by emergency medical services, a feasibility study. [Masters Thesis]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/321298

University of Toronto

19. Stanwick, Jason. Enhanced Bioactivity and Sustained Release of NT-3 and Anti-NogoA from a Polymeric Drug Delivery System for Treatment of Spinal Cord Injury.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/33769

►

Neurotrophin-3 (NT-3) and anti-NogoA have shown promise in regenerative strategies after spinal cord injury; however, conventional methods for localized release to the injured spinal cord… (more)

Subjects/Keywords: Drug release; Spinal cord injury; 0542

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APA (6^th Edition):

Stanwick, J. (2012). Enhanced Bioactivity and Sustained Release of NT-3 and Anti-NogoA from a Polymeric Drug Delivery System for Treatment of Spinal Cord Injury. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/33769

Chicago Manual of Style (16^th Edition):

Stanwick, Jason. “Enhanced Bioactivity and Sustained Release of NT-3 and Anti-NogoA from a Polymeric Drug Delivery System for Treatment of Spinal Cord Injury.” 2012. Masters Thesis, University of Toronto. Accessed March 02, 2021. http://hdl.handle.net/1807/33769.

MLA Handbook (7^th Edition):

Stanwick, Jason. “Enhanced Bioactivity and Sustained Release of NT-3 and Anti-NogoA from a Polymeric Drug Delivery System for Treatment of Spinal Cord Injury.” 2012. Web. 02 Mar 2021.

Vancouver:

Stanwick J. Enhanced Bioactivity and Sustained Release of NT-3 and Anti-NogoA from a Polymeric Drug Delivery System for Treatment of Spinal Cord Injury. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1807/33769.

Council of Science Editors:

Stanwick J. Enhanced Bioactivity and Sustained Release of NT-3 and Anti-NogoA from a Polymeric Drug Delivery System for Treatment of Spinal Cord Injury. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/33769

University of Toronto

20. Chan, Katherine. Reactive stepping ability of individuals with incomplete spinal cord injury.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/91565

►

Up to 75% of individuals with incomplete spinal cord injury (SCI) experience at least one fall each year. Reactive stepping is one strategy used to… (more)

Subjects/Keywords: balance; reactive; spinal cord injury; 0566

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APA (6^th Edition):

Chan, K. (2018). Reactive stepping ability of individuals with incomplete spinal cord injury. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91565

Chicago Manual of Style (16^th Edition):

Chan, Katherine. “Reactive stepping ability of individuals with incomplete spinal cord injury.” 2018. Masters Thesis, University of Toronto. Accessed March 02, 2021. http://hdl.handle.net/1807/91565.

MLA Handbook (7^th Edition):

Chan, Katherine. “Reactive stepping ability of individuals with incomplete spinal cord injury.” 2018. Web. 02 Mar 2021.

Vancouver:

Chan K. Reactive stepping ability of individuals with incomplete spinal cord injury. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1807/91565.

Council of Science Editors:

Chan K. Reactive stepping ability of individuals with incomplete spinal cord injury. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91565

University of Ghana

21. Ampah, B.T. Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital.

Degree: 2018, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/28362

► Nurses encounter several challenges in managing patients with spinal cord injury. However, little is known about this area of nursing care. Thus the purpose of… (more)

Subjects/Keywords: Spinal Cord Injury; Korle-Bu Teaching Hospital

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ampah, B. T. (2018). Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/28362

Chicago Manual of Style (16^th Edition):

Ampah, B T. “Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. ” 2018. Masters Thesis, University of Ghana. Accessed March 02, 2021. http://ugspace.ug.edu.gh/handle/123456789/28362.

MLA Handbook (7^th Edition):

Ampah, B T. “Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. ” 2018. Web. 02 Mar 2021.

Vancouver:

Ampah BT. Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. [Internet] [Masters thesis]. University of Ghana; 2018. [cited 2021 Mar 02]. Available from: http://ugspace.ug.edu.gh/handle/123456789/28362.

Council of Science Editors:

Ampah BT. Experiences of Nurses Managing Patients with Spinal Cord Injury at Korle-Bu Teaching Hospital. [Masters Thesis]. University of Ghana; 2018. Available from: http://ugspace.ug.edu.gh/handle/123456789/28362

University of Adelaide

22. Leonard, Anna Victoria. Characterising the role of substance P following traumatic spinal cord injury.

Degree: 2012, University of Adelaide

URL: http://hdl.handle.net/2440/87149

► Spinal cord injury (SCI) is a devastating injury that commonly results in permanent physical disability. The highest incidence of SCI occurs in younger populations, causing… (more)

▼ Spinal cord injury (SCI) is a devastating injury that commonly results in permanent physical disability. The highest incidence of SCI occurs in younger populations, causing an enormous financial burden to both individuals and society amounting to almost $1 billion annually within Australia spent on hospitalisation, treatment and rehabilitation of spinal cord injured individuals. To date, an effective clinical treatment for SCI remains elusive, highlighting the need for research aimed at developing therapeutic interventions that improve functional outcome. Spinal cord edema is recognised as a common complication of SCI which continues to develop, spreading in a rostrocaudal direction days after injury, resulting in greater tissue damage and functional deficits. Reducing edema following SCI is therefore of utmost importance and represents an attractive target for therapeutic intervention. Substance P (SP) is a neuropeptide known to facilitate the process of neurogenic inflammation, which has previously been shown to result in blood brain barrier (BBB) disruption and subsequent edema development following both traumatic brain injury (TBI) and stroke. Furthermore, inhibition of the high-affinity SP receptor, the tachykinin NK1 receptor, resulted in reduced BBB permeability, edema and improved functional outcome in both of these conditions. Accordingly, the current thesis sought to determine whether SP played a similar role as a mediator of neurogenic inflammation following traumatic SCI. Immunohistochemical assessment of human SCI demonstrated a loss of SP from the dorsal horn region, suggesting that SP release increased following injury. NK1 receptor immunoreactivity was also initially increased post-injury before declining, indicating that receptor activation and subsequent internalisation occurred. Assessment of various open experimental injury models, including the weight drop, hemisection and clip compression models, demonstrated similar SP immunoreactivity as that observed in human tissue, although NK1 receptor immunoreactivity varied in localisation and response to injury. These results highlighted the need for experimental models to accurately replicate the primary injury mechanisms observed clinically, especially the closed environment rather than the open nature of most experimental models. The balloon compression model was subsequently employed for the remainder of the study, given its closed nature and its ability to mimic primary injury mechanisms such as an initial impact followed by persisting compression. This model also proved to replicate many other facets of human injury such as severe hemorrhage, axonal injury, neuronal loss, microglial activation, as well as increased BSCB disruption, edema, intrathecal pressure (ITP) and reduced functional outcome. Balloon compression induced SCI was also associated with reduced SP immunoreactivity, suggesting increased SP release, and increased NK1 receptor immunoreactivity. Such observations implicate a potential role for SP in mediating neurogenic inflammation… Advisors/Committee Members: Vink, Robert (advisor), Blumbergs, Peter Charles (advisor), School of Medical Sciences (school).

Subjects/Keywords: spinal cord injury; substance P; neurogenic inflammation

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APA (6^th Edition):

Leonard, A. V. (2012). Characterising the role of substance P following traumatic spinal cord injury. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/87149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leonard, Anna Victoria. “Characterising the role of substance P following traumatic spinal cord injury.” 2012. Thesis, University of Adelaide. Accessed March 02, 2021. http://hdl.handle.net/2440/87149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leonard, Anna Victoria. “Characterising the role of substance P following traumatic spinal cord injury.” 2012. Web. 02 Mar 2021.

Vancouver:

Leonard AV. Characterising the role of substance P following traumatic spinal cord injury. [Internet] [Thesis]. University of Adelaide; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2440/87149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leonard AV. Characterising the role of substance P following traumatic spinal cord injury. [Thesis]. University of Adelaide; 2012. Available from: http://hdl.handle.net/2440/87149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

23. Moulds, Jessica. The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3789

► At present there is only limited research on the nutrition knowledge and dietary practices of athletes with a disability. The physiological differences in athletes with… (more)

▼ At present there is only limited research on the nutrition knowledge and dietary practices of athletes with a disability. The physiological differences in athletes with disabilities combined with the internal demands and external pressures during sporting events, predispose them to medical and health problems. The growing participation of athletes with disabilities in sporting events such as the Paralympic Games denotes the need for nutrition guidelines specific for these athletes to be produced. Most elite able-bodied athletes have access to nutritional support and education, however, such resources are more difficult for those with disabilities to utilise. Therefore, this study aimed to investigate the basic and sports nutrition knowledge, dietary practices and nutrition education sources of athletes with spinal cord injuries (SCI) compared with their able-bodied (AB) counterparts, using a self-developed questionnaire. Twenty-nine athletes (11 AB, 18 SCI) completed the questionnaire. Overall, there was no significant difference in the nutritional knowledge between athletes with SCI and AB athletes (p=0.4709). However, the results from this study did find potential gaps in nutrition knowledge for both groups. In particular, both groups showed poor knowledge for the role of macronutrients in the body. For example, 36% AB and 56% SCI incorrectly agreed that the more protein you consume, the more muscle you build. There was also a significant difference (p=0.029) between the groups perceived body weight as 27% AB and 67% SCI consider themselves as above their ideal weight. Only 20% of SCI athletes consider their weight as “ideal” compared with 64% of AB athletes. These results indicate that athletes with SCI are more likely to struggle with their weight than AB athletes. Both groups indicated that an individual session with a sports nutritionist or dietitian is the preferred source of nutrition information, although, SCI athletes also reported the internet and interactive website programs to be another good source of nutrition information. More research is needed to assess the overall knowledge of disabled athletes in comparison to their able-bodied counterparts as well as the most appropriate, and effective methods of education for this group. Advisors/Committee Members: Black, Katherine (advisor).

Subjects/Keywords: Nutrition; Knowledge; Spinal; Cord; Injury; Athletes

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APA (6^th Edition):

Moulds, J. (2013). The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3789

Chicago Manual of Style (16^th Edition):

Moulds, Jessica. “The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries .” 2013. Masters Thesis, University of Otago. Accessed March 02, 2021. http://hdl.handle.net/10523/3789.

MLA Handbook (7^th Edition):

Moulds, Jessica. “The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries .” 2013. Web. 02 Mar 2021.

Vancouver:

Moulds J. The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10523/3789.

Council of Science Editors:

Moulds J. The Nutritional Knowledge and Dietary Practices of Athletes with Spinal Cord Injuries . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3789

University of Otago

24. Shaw, David. Nutritional supplement knowledge of athletes with spinal cord injury .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3795

► Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements… (more)

▼ Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements do not possess convincing scientific merit to advise their use and some even have the potential to cause harm. This is of particular concern for athletes with SCI, who often need to manage secondary health complications for optimal performance. Currently, there is a paucity of research on the supplement knowledge of elite athletes and athletes with SCI, as the majority of research has investigated able-bodied (AB) athletes of junior to university level in countries other than New Zealand (NZ). This emphasises the importance to investigate the supplement knowledge and practices of NZ athletes to evaluate how the SCI population compare with the AB population, and how these groups compare to their overseas counterparts. Methods: The present study investigated the nutritional supplement knowledge, practices and reasons for use of 11 elite AB athletes and 15 athletes with SCI in NZ from an online questionnaire. Results: The SCI and AB groups demonstrated moderate levels of supplement knowledge (64.8% AB vs. 57.5% SCI) (p=0.466). Despite this difference being insignificant, the SCI group reported supplement practices relating to the physiological effects of SCI. Supplement practices may have been used as a prevention method against their increased risk of illness and infection, and potentially as a compensatory strategy to augment an obligatory loss of muscle size and strength. This was shown by their higher prevalence for the use of vitamin C (p=0.05) and creatine (p=0.012), and supported by their nutritional beliefs and reasons for supplement use. Conclusions: Although athletes with SCI have similar levels of supplement knowledge as their AB counterparts, this does not mean their knowledge is adequate. Athletes with SCI appear to be disadvantaged regarding their nutritional education and support, particularly in the present study as the majority of AB athletes attended an elite sporting institute. Moreover, nutrition recommendations for athletes with SCI are non-existent, which emphasizes the need for further research to form the basis of nutritional guidelines for this group. Nevertheless, even with the available nutrition information for AB athletes, it is evident NZ athletes with and without SCI are likely to benefit from further nutrition and supplement education. Advisors/Committee Members: Black, Katherine (advisor).

Subjects/Keywords: supplements; knowledge; spinal; cord; injury; nutrition; athlete

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APA (6^th Edition):

Shaw, D. (2013). Nutritional supplement knowledge of athletes with spinal cord injury . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3795

Chicago Manual of Style (16^th Edition):

Shaw, David. “Nutritional supplement knowledge of athletes with spinal cord injury .” 2013. Masters Thesis, University of Otago. Accessed March 02, 2021. http://hdl.handle.net/10523/3795.

MLA Handbook (7^th Edition):

Shaw, David. “Nutritional supplement knowledge of athletes with spinal cord injury .” 2013. Web. 02 Mar 2021.

Vancouver:

Shaw D. Nutritional supplement knowledge of athletes with spinal cord injury . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10523/3795.

Council of Science Editors:

Shaw D. Nutritional supplement knowledge of athletes with spinal cord injury . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3795

University of Otago

25. Shaw, David Mark. Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3875

► Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements… (more)

▼ Background: Nutritional supplements are a temptation for athletes with and without spinal cord injury (SCI) who are attempting to enhance their performance. However, many supplements do not possess convincing scientific merit to advise their use and some even have the potential to cause harm. This is of particular concern for athletes with SCI, who often need to manage secondary health complications for optimal performance. Currently, there is a paucity of research on the supplement knowledge of elite athletes and athletes with SCI, as the majority of research has investigated able-bodied (AB) athletes of junior to university level in countries other than New Zealand (NZ). This emphasises the importance to investigate the supplement knowledge and practices of NZ athletes to evaluate how the SCI population compare with the AB population, and how these groups compare to their overseas counterparts. Methods: The present study investigated the nutritional supplement knowledge, practices and reasons for use of 11 elite AB athletes and 15 athletes with SCI in NZ from an online questionnaire. Results: The SCI and AB groups demonstrated moderate levels of supplement knowledge (64.8% AB vs. 57.5% SCI) (p=0.466). Despite this difference being insignificant, the SCI group reported supplement practices relating to the physiological effects of SCI. Supplement practices may have been used as a prevention method against their increased risk of illness and infection, and potentially as a compensatory strategy to augment an obligatory loss of muscle size and strength. This was shown by their higher prevalence for the use of vitamin C (p=0.05) and creatine (p=0.012), and supported by their nutritional beliefs and reasons for supplement use. Conclusions: Although athletes with SCI have similar levels of supplement knowledge as their AB counterparts, this does not mean their knowledge is adequate. Athletes with SCI appear to be disadvantaged regarding their nutritional education and support, particularly in the present study as the majority of AB athletes attended an elite sporting institute. Moreover, nutrition recommendations for athletes with SCI are non-existent, which emphasizes the need for further research to form the basis of nutritional guidelines for this group. Nevertheless, even with the available nutrition information for AB athletes, it is evident NZ athletes with and without SCI are likely to benefit from further nutrition and supplement education. Advisors/Committee Members: Black, Katherine (advisor).

Subjects/Keywords: Supplements; Athletes; Practices; Knowledge; Spinal; Cord; Injury

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shaw, D. M. (2013). Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3875

Chicago Manual of Style (16^th Edition):

Shaw, David Mark. “Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury .” 2013. Masters Thesis, University of Otago. Accessed March 02, 2021. http://hdl.handle.net/10523/3875.

MLA Handbook (7^th Edition):

Shaw, David Mark. “Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury .” 2013. Web. 02 Mar 2021.

Vancouver:

Shaw DM. Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10523/3875.

Council of Science Editors:

Shaw DM. Nutritional Supplement Knowledge of Athletes with Spinal Cord Injury . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3875

University of Miami

26. Hackett, Amber. The Role of NG2 Cells after Contusive Spinal Cord Injury.

Degree: PhD, Neuroscience (Medicine), 2016, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_dissertations/1767

► NG2 cells, also known as oligodendrocyte progenitor cells (OPCs), are tiled throughout the adult central nervous system (CNS) and proliferate and differentiate into oligodendrocytes… (more)

▼ NG2 cells, also known as oligodendrocyte progenitor cells (OPCs), are tiled throughout the adult central nervous system (CNS) and proliferate and differentiate into oligodendrocytes throughout life. After spinal cord injury (SCI), many oligodendrocytes are lost, and promoting oligodendrocyte differentiation is an appealing target to promote functional recovery after SCI. However, in addition to differentiating into oligodendrocytes, NG2 cells proliferate in the glial scar and contribute to axon regeneration failure. NG2 cells are committed to the oligodendrocyte lineage in adult mice. However, in other models of CNS injury, NG2 cells gain the capacity to differentiate into astrocytes. The astroglial fate of NG2 cells after SCI is currently unknown and is important to investigate because astrocytes are major contributors to the glial scar. To trace the fate of NG2 cells after SCI, I used NG2-CreER mice bred to tdTomato, which serves as a Cre reporter. I found that in addition to increasing their proliferation and differentiation into oligodendrocytes after SCI, NG2 cells gain the capacity to differentiate into astrocytes in the glial scar. Mechanisms that underlie these fate changes are not well understood. Since cytokine ligands for the signal transducer and activator of transcription 3 (STAT3) pathway are upregulated after SCI, and have been implicated in NG2 cell and astrocyte fate, I hypothesized that the transcription factor STAT3 might to an important mediator of NG2 cell fate after SCI. To address the role of STAT3 in NG2 cells after SCI, I used tamoxifen inducible NG2 cell specific deletions of either STAT3 or its suppressor, suppressor of cytokine signaling 3 (SOCS3). I have identified STAT3 as an important regulator of efficient oligodendrogenesis after SCI. Surprisingly, I found that SOCS3 deletion led to increased proliferation of NG2 cells via a STAT3 independent mechanism. I also found that neither STAT3 nor SOCS3 affected astrogliogenesis from NG2 cells after SCI. Altogether these data suggest that STAT3 and SOCS3 are important regulators of NG2 cell proliferation and differentiation after SCI. Understanding mechanisms that mediate NG2 cell proliferation and differentiation in the glial scar is essential since NG2 cells are important players in axon regeneration failure after SCI. My data reveal insight into the role of cytokine signaling in both oligodendrogenesis and proliferation of NG2 cells, and could be used to alter glial scar formation or promote remyelination after SCI. Advisors/Committee Members: Jae K. Lee, Nagi G. Ayad, Eleonore Beurel, Pantelis Tsoulfas.

Subjects/Keywords: Spinal Cord Injury; Glial Scar; Oligodendrocytes; Cytokines

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APA (6^th Edition):

Hackett, A. (2016). The Role of NG2 Cells after Contusive Spinal Cord Injury. (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/1767

Chicago Manual of Style (16^th Edition):

Hackett, Amber. “The Role of NG2 Cells after Contusive Spinal Cord Injury.” 2016. Doctoral Dissertation, University of Miami. Accessed March 02, 2021. https://scholarlyrepository.miami.edu/oa_dissertations/1767.

MLA Handbook (7^th Edition):

Hackett, Amber. “The Role of NG2 Cells after Contusive Spinal Cord Injury.” 2016. Web. 02 Mar 2021.

Vancouver:

Hackett A. The Role of NG2 Cells after Contusive Spinal Cord Injury. [Internet] [Doctoral dissertation]. University of Miami; 2016. [cited 2021 Mar 02]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1767.

Council of Science Editors:

Hackett A. The Role of NG2 Cells after Contusive Spinal Cord Injury. [Doctoral Dissertation]. University of Miami; 2016. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1767

Northeastern University

27. Freitas, Polina D. Cellular and molecular mechanisms of axolotl central and peripheral nervous system response to injury.

Degree: PhD, Department of Biology, 2018, Northeastern University

URL: http://hdl.handle.net/2047/D20293393

► The axolotl (Ambystoma mexicanum) is one of the only known tetrapod vertebrates capable of full spinal cord regeneration. Unfortunately, similar injury in mammals is completely… (more)

Subjects/Keywords: axolotl; nervous system; regeneration; spinal cord injury

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APA (6^th Edition):

Freitas, P. D. (2018). Cellular and molecular mechanisms of axolotl central and peripheral nervous system response to injury. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20293393

Chicago Manual of Style (16^th Edition):

Freitas, Polina D. “Cellular and molecular mechanisms of axolotl central and peripheral nervous system response to injury.” 2018. Doctoral Dissertation, Northeastern University. Accessed March 02, 2021. http://hdl.handle.net/2047/D20293393.

MLA Handbook (7^th Edition):

Freitas, Polina D. “Cellular and molecular mechanisms of axolotl central and peripheral nervous system response to injury.” 2018. Web. 02 Mar 2021.

Vancouver:

Freitas PD. Cellular and molecular mechanisms of axolotl central and peripheral nervous system response to injury. [Internet] [Doctoral dissertation]. Northeastern University; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2047/D20293393.

Council of Science Editors:

Freitas PD. Cellular and molecular mechanisms of axolotl central and peripheral nervous system response to injury. [Doctoral Dissertation]. Northeastern University; 2018. Available from: http://hdl.handle.net/2047/D20293393

Boston University

28. Herman, Paige. Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys.

Degree: MS, Medical Sciences, 2017, Boston University

URL: http://hdl.handle.net/2144/23701

► The lamprey is a basal vertebrate that achieves spontaneous functional recovery after complete spinal cord transection over a stereotypical period of 12 weeks. Despite anatomical,… (more)

Subjects/Keywords: Neurosciences; Lamprey; Regeneration; Spinal cord injury

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APA (6^th Edition):

Herman, P. (2017). Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/23701

Chicago Manual of Style (16^th Edition):

Herman, Paige. “Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys.” 2017. Masters Thesis, Boston University. Accessed March 02, 2021. http://hdl.handle.net/2144/23701.

MLA Handbook (7^th Edition):

Herman, Paige. “Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys.” 2017. Web. 02 Mar 2021.

Vancouver:

Herman P. Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2144/23701.

Council of Science Editors:

Herman P. Functional genomics reveals molecular programs associated with recovery from spinal cord injury in lampreys. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/23701

Loughborough University

29. Kirkby, Joanna. Resilience in people with spinal cord injury : a narrative approach.

Degree: PhD, 2016, Loughborough University

URL: http://hdl.handle.net/2134/23385

► This PhD thesis explores the phenomenon of resilience in people with spinal cord injury (SCI). The purpose of this research is to understand how resilience… (more)

▼ This PhD thesis explores the phenomenon of resilience in people with spinal cord injury (SCI). The purpose of this research is to understand how resilience is experienced and given meaning in people with SCI, as well how resilience is fostered, how it impacts upon health and well-being, and how it can be managed to achieve maximum benefits with regard to health and well-being. It is the first in depth narrative investigation of resilience in people with SCI. Using both life story interviews and the process of timelining, participants stories were collected. Following this they were then analysed using dialogical narrative analysis (Frank, 2010, 2012). This enabled participants stories to be examined with regard to their effects on resilience and health and well-being. The analysis shows that firstly, due to the intangible nature of resilience, participants had trouble in articulating exactly what resilience meant to them. Instead, resilience was shown through participants stories which could be grouped into four different narrative types: loss, adaptation, posttraumatic growth (PTG), and life-as-normal. Together, these narrative types constructed resilience, and as such, resilience in people with SCI has four facets or faces , like a four-sided dice. The process of resilience in people with SCI worked by participants drawing upon the different narrative types at different times depending upon the demands being placed upon them. The loss narrative was drawn upon immediately following injury, and was concerned with the narration of the physical, psychological and social losses participants incurred following SCI. The loss narrative fostered resilience by enabling participants to talk about their losses, enabling participants to survive the hardest time of their lives. The second narrative type was the adaptation narrative. This narrative type focussed upon rehabilitation in both the spinal unit and in the community. This narrative type built resilience via progression through rehabilitation towards a quality of life comparable to pre-injury levels. The PTG narrative was concerned with the ways in which participants had developed following SCI and built resilience by shifting the focus onto the positives to come out of participants experiences of SCI. The life-as-normal narrative was used by two participants across their entire life story and enabled participants to continue with their lives with minimal disruption. It built resilience by placing disability in the background and therefore making it unimportant. This thesis then concludes with the empirical, theoretical, methodological and practical implications arising from this research. The potential for resilience to help improve the health and well-being of people with SCI is discussed, as well as the ways in which resilience can have a maximum benefit on health and well-being of people with SCI.

Subjects/Keywords: 617.4; Resilience; Spinal cord injury; Disability; Narrative

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APA (6^th Edition):

Kirkby, J. (2016). Resilience in people with spinal cord injury : a narrative approach. (Doctoral Dissertation). Loughborough University. Retrieved from http://hdl.handle.net/2134/23385

Chicago Manual of Style (16^th Edition):

Kirkby, Joanna. “Resilience in people with spinal cord injury : a narrative approach.” 2016. Doctoral Dissertation, Loughborough University. Accessed March 02, 2021. http://hdl.handle.net/2134/23385.

MLA Handbook (7^th Edition):

Kirkby, Joanna. “Resilience in people with spinal cord injury : a narrative approach.” 2016. Web. 02 Mar 2021.

Vancouver:

Kirkby J. Resilience in people with spinal cord injury : a narrative approach. [Internet] [Doctoral dissertation]. Loughborough University; 2016. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2134/23385.

Council of Science Editors:

Kirkby J. Resilience in people with spinal cord injury : a narrative approach. [Doctoral Dissertation]. Loughborough University; 2016. Available from: http://hdl.handle.net/2134/23385

Delft University of Technology

30. Bleijswijk, T. (author). Courtyard rehabilitation.

Degree: 2015, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:d400a2b1-4423-4e0c-b008-b3574f29e2ba

A healing environment for patients with a Spinal Cord Injury in Amsterdam North.

The Healthy Environment

The Architecture of the Interior

Architecture and The Built Environment

Advisors/Committee Members: Stulhmacher, M.E. (mentor), Schreurs, E.P.N. (mentor), Meijs, M.H. (mentor).

Subjects/Keywords: rehabilitation; healing environment; spinal cord injury

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APA (6^th Edition):

Bleijswijk, T. (. (2015). Courtyard rehabilitation. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:d400a2b1-4423-4e0c-b008-b3574f29e2ba

Chicago Manual of Style (16^th Edition):

Bleijswijk, T (author). “Courtyard rehabilitation.” 2015. Masters Thesis, Delft University of Technology. Accessed March 02, 2021. http://resolver.tudelft.nl/uuid:d400a2b1-4423-4e0c-b008-b3574f29e2ba.

MLA Handbook (7^th Edition):

Bleijswijk, T (author). “Courtyard rehabilitation.” 2015. Web. 02 Mar 2021.

Vancouver:

Bleijswijk T(. Courtyard rehabilitation. [Internet] [Masters thesis]. Delft University of Technology; 2015. [cited 2021 Mar 02]. Available from: http://resolver.tudelft.nl/uuid:d400a2b1-4423-4e0c-b008-b3574f29e2ba.

Council of Science Editors:

Bleijswijk T(. Courtyard rehabilitation. [Masters Thesis]. Delft University of Technology; 2015. Available from: http://resolver.tudelft.nl/uuid:d400a2b1-4423-4e0c-b008-b3574f29e2ba

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Open Access Theses and Dissertations