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You searched for subject:(Solvolytic). Showing records 1 – 3 of 3 total matches.

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1. Uniyal, Vanshi. Studies on solvolytic structural transformation and degradation of cellulose; -.

Degree: Chemistry and forest product, 2014, Forest Research Institute University

None

Publication given

Advisors/Committee Members: Gupta,P K.

Subjects/Keywords: Cellulose; Degradation; Solvolytic; Studies; Transformation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Uniyal, V. (2014). Studies on solvolytic structural transformation and degradation of cellulose; -. (Thesis). Forest Research Institute University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/51030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Uniyal, Vanshi. “Studies on solvolytic structural transformation and degradation of cellulose; -.” 2014. Thesis, Forest Research Institute University. Accessed July 22, 2018. http://shodhganga.inflibnet.ac.in/handle/10603/51030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Uniyal, Vanshi. “Studies on solvolytic structural transformation and degradation of cellulose; -.” 2014. Web. 22 Jul 2018.

Vancouver:

Uniyal V. Studies on solvolytic structural transformation and degradation of cellulose; -. [Internet] [Thesis]. Forest Research Institute University; 2014. [cited 2018 Jul 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/51030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Uniyal V. Studies on solvolytic structural transformation and degradation of cellulose; -. [Thesis]. Forest Research Institute University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/51030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Boise State University

2. Muhammed, Thaaer N. Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene.

Degree: 2018, Boise State University

Mitomycin C (MC) is a naturally occurring antitumor agent isolated from a soil bacterium. MC is effective against solid hypoxic tumors that respond poorly to radiotherapy, such as colorectal, gastric, and lung tumors. Also, it has a role in the treatment of bladder, head and neck, and non-small cell lung cancers in combination with other chemotherapeutic. MC and other members of the mitomycin family of antitumor agents fight cancer by forming DNA interstrand crosslinks (ICLs), which leads to apoptosis. In order to form ICLs, MC requires a reductive activation step that produces reactive oxygen species. This activation step is proposed to lead to adverse side effects, such as myelosuppression and hemolytic uremic syndrome. Aziridinomitosenes (AZMs) are structurally related to MC and are believed to form during in vivo reduction of MC. AZMs are relatively stable but are more sensitive than the parent mitomycins due to an activated aziridine ring. Consequently, AZMs do not require the reductive activation step in order to alkylate DNA. The purpose of this work is to synthesize and study an AZM that is substituted with methyl groups at two potential electrophilic sites. It is hypothesized that certain synthetic AZMs crosslink DNA under non-reductive conditions as a result of a nucleophilic activation sequence involving the quinone ring. To test this hypothesis, analogs were prepared that would either reduce the rate of the activation step or prevent it from occurring. The synthetic route starts with commercially available reagents to form an oxazole, followed by the addition of a protected aldehyde that is converted to the required aziridine ring via a Mitsunobu reaction. Once the aziridine ring is formed, all of the reaction conditions must be conducted using mild conditions in order to prevent ring-opening. The completion of the synthesis and formation of the tetracyclic core was achieved by performing an oxazolium salt/azomethine ylide [3+2] cycloaddition sequence. This sequence was conducted multiple times, and the highest yield obtained was 44%. The final steps were the most challenging, requiring several transformations to accomplish a deprotection and oxidation to give a diketone that was oxidized to a quinone. Finally, the carbamate was attached in two steps using FmocNCO to yield the desired AZM product in an overall yield of 0.04% from the starting diol over the 22 step reaction sequence. The stability of the AZM was tested in buffered methanolic solutions, and the results were compared to other aziridinomitosenes. While unsubstituted AZMs decompose in basic solutions, the C6/C7 dimethyl AZM showed high stability under these conditions.

Subjects/Keywords: Mitomycin C; aziridinomitosenes; azomethine ylide; solvolytic stability; Organic Chemicals; Other Chemicals and Drugs; Pharmaceutical Preparations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Muhammed, T. N. (2018). Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene. (Thesis). Boise State University. Retrieved from https://scholarworks.boisestate.edu/td/1404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Muhammed, Thaaer N. “Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene.” 2018. Thesis, Boise State University. Accessed July 22, 2018. https://scholarworks.boisestate.edu/td/1404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Muhammed, Thaaer N. “Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene.” 2018. Web. 22 Jul 2018.

Vancouver:

Muhammed TN. Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene. [Internet] [Thesis]. Boise State University; 2018. [cited 2018 Jul 22]. Available from: https://scholarworks.boisestate.edu/td/1404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Muhammed TN. Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene. [Thesis]. Boise State University; 2018. Available from: https://scholarworks.boisestate.edu/td/1404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Univerzitet u Beogradu

3. Bajuk-Bogdanović, Danica V., 1977-. Ispitivanje stabilnosti 12-volframfosforne, 12-volframsilicijumove i 12-molibdenfosforne kiseline u rastvorima.

Degree: Fakultet za fizičku hemiju, 2016, Univerzitet u Beogradu

Fizička hemija - Fizička hemija materijala / Physical Chemistry - Physical Chemistry of Materials

12-volframfosforna (WPA), 12-volframsilicijumova (WSiA) i 12-molibdenfosforna kiselina (MoPA) su heteropoli kiseline (HPK) koje pripadaju velikoj klasi jedinjenja koja se nazivaju polioksometalati. U osnovi struktura ovih kiselina je Keggin-ov anjon (KA) čija se hidrolitička stabilnost razlikuje od kiseline do kiseline, što je utvrđeno ULj, IC, ramanskom i 31P NMR spektroskopijom. Najmanje je stabilna MoPA, kod koje roditeljska Keggin-ova struktura u razblaženim rastvorima (2∙10-5 moldm-3) nije prisutna čak ni pri pH < 1,0, a u koncentrovanim rastvorima (5∙10-2 moldm-3) egzistira samo pri pH < 1,0. WPA je stabilnija, i kod nje je roditeljski anjon prisutan pri pH < 1,0 u razblaženim, odnosno pH < 1,5 u koncentrovanim rastvorima. Najstabilnija je WSiA, kod koje je KA prisutan u razblaženim vodenim rastvorima do pH = 8,5 odnosno do pH = 6,4 u koncentrovanim rastvorima. Korišćenje 50 % metanola kao rastvarača dovodi do stabilizacije KA u ovim kiselinama, tako da se u slučaju MoPA javlja sve do pH = 3,5 i u razblaženim i u koncentrovanim rastvorima. Za WPA u koncentrovanim rastvorima oblast pH u kojoj se javlja KA se proširuje do pH = 2,5, a u razblaženim čak i do pH = 7,0. Najstabilnija WSiA se dodatno stabiliše u prisustvu metanola, pa se KA javlja sve do pH = 11,5 u razblaženim, odnosno pH = 7,8 u koncentrovanim rastvorima. Proces dekompozicije WPA je delimično reverzibilan, a za vodene rastvore je potvrđena vremenska stabilnost u toku jedne godine. Prilikom upotrebe pufera za podešavanje pH vrednosti rastvora HPK, mora se voditi računa o mogućoj interakciji HPK sa puferom, kao što je to slučaj pri primeni TRIS pufera. Dobijeni rezultati se mogu iskoristiti za utvrđivanje oblika HPK prisutnih u različitim sistemima. U slučaju polianilin - WPA mikro/nanostruktura KA je dominantno prisutna vrsta, ali se identifikuju i male količine Dawson-ovog i monolakunarnog KA. WPA i WSiA u inkubacionom medijumu (uz prisustvo enzima Na+/K+_ATPaze i ATP), u obliku monolakunarnog KA, inhibiraju dejstvo enzima Na+/K+_ATPaze, što je od značaja za različite biohemijske procese.

Advisors/Committee Members: Holclajtner-Antunović, Ivanka, 1949-.

Subjects/Keywords: heteropoly acids; solvolytic stability; pH values; UV; IR; Raman and NMR spectroscopy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bajuk-Bogdanović, Danica V., 1. (2016). Ispitivanje stabilnosti 12-volframfosforne, 12-volframsilicijumove i 12-molibdenfosforne kiseline u rastvorima. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:13077/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Bajuk-Bogdanović, Danica V., 1977-. “Ispitivanje stabilnosti 12-volframfosforne, 12-volframsilicijumove i 12-molibdenfosforne kiseline u rastvorima.” 2016. Thesis, Univerzitet u Beogradu. Accessed July 22, 2018. https://fedorabg.bg.ac.rs/fedora/get/o:13077/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Bajuk-Bogdanović, Danica V., 1977-. “Ispitivanje stabilnosti 12-volframfosforne, 12-volframsilicijumove i 12-molibdenfosforne kiseline u rastvorima.” 2016. Web. 22 Jul 2018.

Vancouver:

Bajuk-Bogdanović, Danica V. 1. Ispitivanje stabilnosti 12-volframfosforne, 12-volframsilicijumove i 12-molibdenfosforne kiseline u rastvorima. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2018 Jul 22]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:13077/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bajuk-Bogdanović, Danica V. 1. Ispitivanje stabilnosti 12-volframfosforne, 12-volframsilicijumove i 12-molibdenfosforne kiseline u rastvorima. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:13077/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.