Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for subject:(Snai2). Showing records 1 – 3 of 3 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of New Mexico

1. Quan, Krystle K. The Role of Snai2/Slug in Diabetes-impaired Wound Healing.

Degree: Biomedical Sciences Graduate Program, 2013, University of New Mexico

Impaired wound healing is a common complication of diabetes mellitus. Advanced glycation end products (AGEs) are a consequence of diabetes and are formed from non-enzymatic reactions between glucose and proteins. The accumulation of AGEs is believed to disrupt wound repair and alter protein function. The epidermal growth factor receptor (EGFR) and a downstream effector, Snai2/Slug, are key regulators of reepithelialization, a vital component of wound healing. Reepithelialization requires keratinocyte proliferation and migration. Therefore, we examined the impact of AGEs on these EGF-stimulated responses. In this dissertation, I present evidence for a critical role of Snai2 in diabetes-impaired wound reepithelialization, extending the knowledge of Snai2 past normal wound repair. A well-studied AGE precursor, glyoxal, was used to model a diabetic environment. Glyoxal decreased EGF-stimulated EGFR activation, leading to impaired keratinocyte proliferation and migration in cell culture and in tissue explants. EGF-stimulated and basal Snai2 protein levels decreased following glyoxal treatment, and this decrease was prevented by the glycation inhibitor, aminoguanidine. Snai2 immunoprecipitated from glyoxal-exposed cells was modified by the AGE product carboxymethyl lysine, identifying Snai2 as an intracellular target of glycation. Furthermore, mice over-expressing Snai2 demonstrated enhanced epithelial outgrowth compared to wild type mice when exposed to glyoxal ex vivo. These data represent a significant breakthrough in the field of diabetes and wound healing as it is the first evidence linking Snai2 down-regulation by pathophysiologic stimuli to impairments in reepithelialization. In addition, few intracellular proteins have been identified as targets of glycation, and this work highlights Snai2 as a novel nuclear protein target with demonstrated relevance to diabetic healing. With this knowledge, we may explore methods to pharmacologically induce Snai2 protein to promote healing of diabetic wounds. Advisors/Committee Members: Hudson, Laurie G., Felton, Linda, McGuire, Paul, Ozbun, Michelle.

Subjects/Keywords: EGFR; Diabetes; Glyoxal; Snai2; Wound Healing; Advanced Glycation End Products

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Quan, K. K. (2013). The Role of Snai2/Slug in Diabetes-impaired Wound Healing. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/141

Chicago Manual of Style (16th Edition):

Quan, Krystle K. “The Role of Snai2/Slug in Diabetes-impaired Wound Healing.” 2013. Doctoral Dissertation, University of New Mexico. Accessed July 19, 2019. https://digitalrepository.unm.edu/biom_etds/141.

MLA Handbook (7th Edition):

Quan, Krystle K. “The Role of Snai2/Slug in Diabetes-impaired Wound Healing.” 2013. Web. 19 Jul 2019.

Vancouver:

Quan KK. The Role of Snai2/Slug in Diabetes-impaired Wound Healing. [Internet] [Doctoral dissertation]. University of New Mexico; 2013. [cited 2019 Jul 19]. Available from: https://digitalrepository.unm.edu/biom_etds/141.

Council of Science Editors:

Quan KK. The Role of Snai2/Slug in Diabetes-impaired Wound Healing. [Doctoral Dissertation]. University of New Mexico; 2013. Available from: https://digitalrepository.unm.edu/biom_etds/141

2. WANG WEI. ROLES OF SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 (S1P2) IN NEURAL AND CANCER CELLS: IMPLICATION FOR PREVENTION OF CISPLATIN-INDUCED PERIPHERAL NEUROPATHY.

Degree: 2018, National University of Singapore

Subjects/Keywords: S1P2; Cisplatin; Allodynia; Sphk1; Snai2; MRTF-A

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

WEI, W. (2018). ROLES OF SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 (S1P2) IN NEURAL AND CANCER CELLS: IMPLICATION FOR PREVENTION OF CISPLATIN-INDUCED PERIPHERAL NEUROPATHY. (Thesis). National University of Singapore. Retrieved from https://scholarbank.nus.edu.sg/handle/10635/154982

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

WEI, WANG. “ROLES OF SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 (S1P2) IN NEURAL AND CANCER CELLS: IMPLICATION FOR PREVENTION OF CISPLATIN-INDUCED PERIPHERAL NEUROPATHY.” 2018. Thesis, National University of Singapore. Accessed July 19, 2019. https://scholarbank.nus.edu.sg/handle/10635/154982.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

WEI, WANG. “ROLES OF SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 (S1P2) IN NEURAL AND CANCER CELLS: IMPLICATION FOR PREVENTION OF CISPLATIN-INDUCED PERIPHERAL NEUROPATHY.” 2018. Web. 19 Jul 2019.

Vancouver:

WEI W. ROLES OF SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 (S1P2) IN NEURAL AND CANCER CELLS: IMPLICATION FOR PREVENTION OF CISPLATIN-INDUCED PERIPHERAL NEUROPATHY. [Internet] [Thesis]. National University of Singapore; 2018. [cited 2019 Jul 19]. Available from: https://scholarbank.nus.edu.sg/handle/10635/154982.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

WEI W. ROLES OF SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 (S1P2) IN NEURAL AND CANCER CELLS: IMPLICATION FOR PREVENTION OF CISPLATIN-INDUCED PERIPHERAL NEUROPATHY. [Thesis]. National University of Singapore; 2018. Available from: https://scholarbank.nus.edu.sg/handle/10635/154982

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidad de Salamanca

3. Hontecillas Prieto, Lourdes. Participación del gen SNAI2/SLUG en el desarrollo y evolución de los adenocarcinomas de mama y pulmón in vivo.

Degree: 2014, Universidad de Salamanca

[EN] Breast tumors and lung cancers are the leading cause of cancer death in the Western World. Death comes mainly determined by distant spread or metastasis, although lung cancer also have relevance complications due to local progression. Therefore, we are interested in better understanding the molecular mechanisms and cellular determinants of poor prognosis of these tumors. Advisors/Committee Members: Pérez Losada, Jesús.

Subjects/Keywords: Tesis y disertaciones académicas; Universidad de Salamanca (España); Academic dissertations; Oncologia; Oncology; Gen Snai2/Slug; Materias::Investigación::24 Ciencias de la vida::2407 Biología celular

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hontecillas Prieto, L. (2014). Participación del gen SNAI2/SLUG en el desarrollo y evolución de los adenocarcinomas de mama y pulmón in vivo. (Thesis). Universidad de Salamanca. Retrieved from http://hdl.handle.net/10366/123010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Hontecillas Prieto, Lourdes. “Participación del gen SNAI2/SLUG en el desarrollo y evolución de los adenocarcinomas de mama y pulmón in vivo.” 2014. Thesis, Universidad de Salamanca. Accessed July 19, 2019. http://hdl.handle.net/10366/123010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Hontecillas Prieto, Lourdes. “Participación del gen SNAI2/SLUG en el desarrollo y evolución de los adenocarcinomas de mama y pulmón in vivo.” 2014. Web. 19 Jul 2019.

Vancouver:

Hontecillas Prieto L. Participación del gen SNAI2/SLUG en el desarrollo y evolución de los adenocarcinomas de mama y pulmón in vivo. [Internet] [Thesis]. Universidad de Salamanca; 2014. [cited 2019 Jul 19]. Available from: http://hdl.handle.net/10366/123010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hontecillas Prieto L. Participación del gen SNAI2/SLUG en el desarrollo y evolución de los adenocarcinomas de mama y pulmón in vivo. [Thesis]. Universidad de Salamanca; 2014. Available from: http://hdl.handle.net/10366/123010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.