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University of Arizona
1.
Mariscal, Norma Linda.
Management of Postoperative Obstructive Sleep Apnea
.
Degree: 2017, University of Arizona
URL: http://hdl.handle.net/10150/624558 
► Background: Obstructive sleep apnea (OSA) is a sleep disorder characterized by episodes of cessation of breathing (apnea) during sleep. Unfortunately, a significant number of surgical…
(more)
▼ Background: Obstructive
sleep apnea (OSA) is a
sleep disorder characterized by episodes of cessation of breathing (
apnea) during
sleep. Unfortunately, a significant number of surgical patients are unaware they are afflicted with this disorder increasing the risks of postoperative complications. The lingering effect of general anesthesia causes an increase in frequency of airway collapse, leading to longer periods of
apnea. This increasingly common
sleep disorder is concerning for many anesthesia providers. Purpose: The purpose of this study was to evaluate the anesthesia provider's knowledge and postoperative management of patients with suspected or diagnosed OSA. Setting: The study setting was a local urban hospital Mountain Vista Medical Center (MVMC) in Gilbert, AZ. The study included (N=7) participants, who were predominantly male (85%) and a majority of the participants were Master’s prepared (85%) anesthesia providers. Method: An online survey was disseminated to participants via email. The survey included questions regarding the anesthesia provider's knowledge and postoperative practice habits of patients with suspected or diagnosed OSA at MVMC. Results: The response rate was (24%). All the respondents acknowledged that OSA was a risk factor for postoperative complications. Over half of the respondents (85%) reported encountering postoperative complications such as desaturation and
apnea in their patients with OSA. The main complication that was encountered was postoperative
apnea (50%), followed by decreased in saturations (33.33%), and one respondent (16.67%) encountered re-intubation during the postoperative period. However, the most important finding of the study is that over half of the providers did not routinely include continued positive airway pressure (CPAP)/noninvasive positive pressure ventilation (NIPPV) in their postoperative management of patients with suspected or known OSA due to the time needed to initiate the therapy. Conclusion: The study illustrates that a majority of anesthesia providers at MVMC agreed OSA is a significant risk factor for postoperative complications, but time constraints limited the implementation of noninvasive ventilation (NIV) therapies. Recommended strategies would be to establish a task force to examine this barrier to therapy and develop plans to address it.
Advisors/Committee Members: Love, Rene (advisor), Love, Rene (committeemember), Piotrowski, Kathleen (committeemember), Erickson, Lisa (committeemember).
Subjects/Keywords: Obstructive Sleep Apnea
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APA (6th Edition):
Mariscal, N. L. (2017). Management of Postoperative Obstructive Sleep Apnea
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/624558
Chicago Manual of Style (16th Edition):
Mariscal, Norma Linda. “Management of Postoperative Obstructive Sleep Apnea
.” 2017. Doctoral Dissertation, University of Arizona. Accessed November 15, 2019.
http://hdl.handle.net/10150/624558.
MLA Handbook (7th Edition):
Mariscal, Norma Linda. “Management of Postoperative Obstructive Sleep Apnea
.” 2017. Web. 15 Nov 2019.
Vancouver:
Mariscal NL. Management of Postoperative Obstructive Sleep Apnea
. [Internet] [Doctoral dissertation]. University of Arizona; 2017. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/10150/624558.
Council of Science Editors:
Mariscal NL. Management of Postoperative Obstructive Sleep Apnea
. [Doctoral Dissertation]. University of Arizona; 2017. Available from: http://hdl.handle.net/10150/624558
University of Alberta
2.
Nazarali, Natasha.
Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms.
Degree: MS, Medical Sciences-Orthodontics, 2016, University of Alberta
URL: https://era.library.ualberta.ca/files/cgq67jr39s
► Objective: To determine the predictive ability of the Alberta Pediatric Obstructive Sleep Apnea (APOSA) Index for orthodontic treatment need in pediatric patients with obstructive sleep…
(more)
▼ Objective: To determine the predictive ability of the
Alberta Pediatric Obstructive Sleep Apnea (APOSA) Index for
orthodontic treatment need in pediatric patients with obstructive
sleep apnea symptoms. Methods: Thirty orthodontic records,
representing a spectrum of craniofacial and oral features and
severity, were evaluated for orthodontic treatment need using the
APOSA index. The results were compared to treatment decisions made
by ten expert orthodontists. Results: Receiver operating
characteristic (ROC) curve demonstrated a cutoff score of 6.5 with
a sensitivity of 94.1% and specificity of 99%. Conclusions: The
APOSA index is a useful and predictive tool to determine
orthodontic treatment need in pediatric patients with OSA symptoms.
A sum score of 6.5 or greater on the APOSA index suggests that the
patient may benefit from referral to an orthodontist. Our findings
indicate that the APOSA index is a useful and predictive tool for
orthodontic treatment need in pediatric patients with OSA
symptoms.
Subjects/Keywords: orthodontics; obstructive sleep apnea; index
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APA (6th Edition):
Nazarali, N. (2016). Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cgq67jr39s
Chicago Manual of Style (16th Edition):
Nazarali, Natasha. “Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms.” 2016. Masters Thesis, University of Alberta. Accessed November 15, 2019.
https://era.library.ualberta.ca/files/cgq67jr39s.
MLA Handbook (7th Edition):
Nazarali, Natasha. “Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms.” 2016. Web. 15 Nov 2019.
Vancouver:
Nazarali N. Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms. [Internet] [Masters thesis]. University of Alberta; 2016. [cited 2019 Nov 15].
Available from: https://era.library.ualberta.ca/files/cgq67jr39s.
Council of Science Editors:
Nazarali N. Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms. [Masters Thesis]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/cgq67jr39s
University of Technology, Sydney
3.
Maali, Y.
An automatic sleep apnea analysis with soft computing approaches.
Degree: 2014, University of Technology, Sydney
URL: http://hdl.handle.net/10453/30399
► Sleep Apnea (SA) is a common disorder without “age-specific” that affects approximately 2% of women and 4% of men; sleep apnea is characterized by repetitive…
(more)
▼ Sleep Apnea (SA) is a common disorder without “age-specific” that affects approximately 2% of women and 4% of men; sleep apnea is characterized by repetitive cessation of breathing during sleep. The consequences of the sleep apnea include daytime sleepiness, impaired cognitive function, impaired memory, neurocognitive dysfunction, and development of cardiovascular disorders, metabolic dysfunction, and impaired quality of life. This thesis investigates the automated detection and prediction of sleep apnea. Many researchers have concentrated on automated detection of sleep apnea, but not much comprehensive or well-ordered work has been done on signal and feature selection or on predicting of the sleep apnea.
The objective is to find the best set of signals as input and the best set of features from selected signals that can be used by a machine learning approaches to study sleep apnea. The best set here is not only refers to a smallest set of signals with a good performance in sleep apnea analysis but also consideration for a set of signals that can be easily acquired from patients.
During the course of this thesis, several algorithms were developed. These algorithms can be used in sleep apnea studies or in wider machine learning areas. The most important contributions of this thesis can be summarized as below:
-Developing a new signal segmentation algorithm designed specifically for sleep apnea by attention to its properties. This algorithm chose times windows with a greater probability of containing at least one sleep apnea event. After that these segmentations are generated, they should be reviewed by the machine learning approaches to be classified as sleep apnea or normal.
-Developing a novel Support Vector Machine (SVM)-based approach named Self-Advising Support Vector Machine (SA-SVM) that transfers more knowledge from the training phase of SVM to the test phase. This idea helps SVM to learn from misclassified data in training phase and use this gained knowledge, in the testing phase. This approach can be used in any binary classification problems and it shows also high impact in sleep apnea detection.
-Developing a new parallel structure for Particle Swarm Optimisation (PSO). Finding the best set of input signals or the best set of features required a huge amount of computation power which a single PSO – or other optimisation approaches- cannot deal with, so a new hierarchical multi-master structure for parallel PSO was developed in this thesis, which quickly revealed its advantages over previous parallel PSO structures.
In this thesis real data has been used from Concord Repatriation General Hospital in Sydney. Obtained result shows a good performance in detection and classification of sleep apnea. Together with detection and classification, a prediction of sleep apnea was also considered. The prediction stage examines some famous neural networks structures and demonstrated how to improve the final result by taking advantage of multi neural network approach.
Subjects/Keywords: Sleep Apnea.; Soft Computing.
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Manager
APA (6th Edition):
Maali, Y. (2014). An automatic sleep apnea analysis with soft computing approaches. (Thesis). University of Technology, Sydney. Retrieved from http://hdl.handle.net/10453/30399
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Maali, Y. “An automatic sleep apnea analysis with soft computing approaches.” 2014. Thesis, University of Technology, Sydney. Accessed November 15, 2019.
http://hdl.handle.net/10453/30399.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Maali, Y. “An automatic sleep apnea analysis with soft computing approaches.” 2014. Web. 15 Nov 2019.
Vancouver:
Maali Y. An automatic sleep apnea analysis with soft computing approaches. [Internet] [Thesis]. University of Technology, Sydney; 2014. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/10453/30399.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Maali Y. An automatic sleep apnea analysis with soft computing approaches. [Thesis]. University of Technology, Sydney; 2014. Available from: http://hdl.handle.net/10453/30399
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Akron
4.
Ankrah, Naa Kwaduah.
The Improvement in Obstructive Sleep Apnea and Sleep
Duration and its Association with Changes Macronutrient Intake in
Adults.
Degree: MSin Nutrition and Dietetics, Nutrition and Dietetics, 2010, University of Akron
URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1279563986
► Background: Obstructive Sleep Apnea (OSA) is prevalent in three to seven percent of American adults, and the diagnostic criterion is the Apnea-Hypopnea Index (AHI).…
(more)
▼ Background: Obstructive
Sleep Apnea (OSA) is
prevalent in three to seven percent of American adults, and the
diagnostic criterion is the
Apnea-Hypopnea Index (AHI). While
obesity is a major cause of OSA, various researchers have reported
significant associations between moderate to severe OSA,
sleep
curtailment and increased caloric intake. Also, when energy intake
exceeds output over time it results in obesity, a public health
problem associated with other diseases. Purpose:
The study aimed to find a significant relationship between
improvement in OSA with change in total energy intake and also a
change in the proportion of energy as percent fat, carbohydrate and
protein. If energy intake decreased, it will then be accompanied
with some weight loss overtime to help control OSA related
obesity. Methods: Fifty-three subjects with
moderate to severe OSA (AHI=15) were recruited from an existing
data set available from the study ‘Effect of
Sleep Apnea Treatment
on Metabolic Syndrome’ conducted from 2003 to 2007 at the Dahms
Clinical Research Unit in Cleveland, Ohio. Access to data was made
available by the principal investigator, Dr. Susan Redline. Dietary
information from a 24-hour recall was entered into Nutrition Data
Systems for Research (NDSR) software and analyzed with Microsoft
Excel and JMP statistical tools by the researcher.
Results: As OSA improved there was a significant increase
in the percentage of total kilocalories (kcal) consumed as fat
(p=0.046). Conversely, the percentage of total kcal consumed as
carbohydrate and protein did not change with improvement in
OSA. Conclusion: Dietary intakes of total
energy, carbohydrate and protein were not significantly different
after improvement in OSA after Continous Positive Airway Pressure
(CPAP). However, improvement in OSA was associated with an increase
in the percentage of kcal consumed as fat. Considering the
limitations associated with the use of a 24-hour recall, this area
of research needs additional study with multiple dietary collection
and energy expenditure methodology and determination. Perhaps
additional thorough dietary analyses would more clearly demonstrate
the alterations and trends in macronutrient intakes with OSA
improvement.
Advisors/Committee Members: Marino, Dr. Deborah (Advisor).
Subjects/Keywords: Nutrition; Obstructive; Sleep Apnea; Macronutrient
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APA (6th Edition):
Ankrah, N. K. (2010). The Improvement in Obstructive Sleep Apnea and Sleep
Duration and its Association with Changes Macronutrient Intake in
Adults. (Masters Thesis). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1279563986
Chicago Manual of Style (16th Edition):
Ankrah, Naa Kwaduah. “The Improvement in Obstructive Sleep Apnea and Sleep
Duration and its Association with Changes Macronutrient Intake in
Adults.” 2010. Masters Thesis, University of Akron. Accessed November 15, 2019.
http://rave.ohiolink.edu/etdc/view?acc_num=akron1279563986.
MLA Handbook (7th Edition):
Ankrah, Naa Kwaduah. “The Improvement in Obstructive Sleep Apnea and Sleep
Duration and its Association with Changes Macronutrient Intake in
Adults.” 2010. Web. 15 Nov 2019.
Vancouver:
Ankrah NK. The Improvement in Obstructive Sleep Apnea and Sleep
Duration and its Association with Changes Macronutrient Intake in
Adults. [Internet] [Masters thesis]. University of Akron; 2010. [cited 2019 Nov 15].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1279563986.
Council of Science Editors:
Ankrah NK. The Improvement in Obstructive Sleep Apnea and Sleep
Duration and its Association with Changes Macronutrient Intake in
Adults. [Masters Thesis]. University of Akron; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1279563986
University of Cincinnati
5.
Kalra, Maninder.
Genetic Susceptibility to Obstructive Sleep Apnea in
Children.
Degree: PhD, Medicine : Epidemiology (Environmental
Health), 2008, University of Cincinnati
URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226552538
► Introduction: Obstructive sleep apnea (OSA) affects 2%-5% children and is associated with neurocognitive deficits and cardiovascular and metabolic sequelae. Familial aggregation and heritability of…
(more)
▼ Introduction: Obstructive
sleep apnea (OSA)
affects 2%-5% children and is associated with neurocognitive
deficits and cardiovascular and metabolic sequelae. Familial
aggregation and heritability of this disorder support a genetic
basis for OSA. The overall objective of this research is to
identify factors that explain genetic susceptibility to OSA in
children. This will enable early diagnosis and therefore
intervention, ultimately resulting in reduction in morbidity and
the public health concerns associated with OSA in children. The
overall research objective will be evaluated with the following two
hypotheses. <i>Hypothesis 1: Polymorphisms in candidate genes
for central adiposity, craniofacial development, skeletal muscle
development, control of breathing and airway collapsibility will be
associated with OSA status in children. Hypothesis 2: The genetic
risk to OSA is explained by a combination of SNPs which are
individually associated with OSA status.</i>
Methods: One hundred and sixty five Caucasian children
with OSA, age 2-18 yrs, were recruited as cases. A control group of
approximately twice the number of children as in the case group
(N=381), with group matching for race and gender, were recruited
from subjects enrolled in the Princeton school district study.
Comparison of allele frequencies between cases and controls was
done by constructing a r x c contingency table- association
statistic whose significance was judged by permutation tests.
Hardy- Weinberg test of genotype frequencies and Linkage
Disequilibrium plot was performed by Helix Tree® version 3.1.
Logistic regression analysis was used to explore the effects of
multiple genetic variants on disease expression after controlling
for BMIz score. Results: Of the 34 SNPs with
genotyping success rate of = 70%, 3 SNPs (rs709156, rs405509 and
rs9905842) did not meet Hardy-Weinberg Equilibrium expectation at a
P value of 0.001. Comparison of allele frequencies between cases
and controls revealed significant differences for 14 of the 31 SNPs
included in the analysis (P<0.05). Multivariate logistic
regression analysis with OSA (dichotomous) as the dependent
variable and BMIz score as covariate revealed a significant
association (P<0.001) between OSA and 4 SNPs (rs3121, rs1163254,
rs7207113 and rs8110090). The 4 SNPs that were significantly
associated with OSA in logistic regression analysis were used to
calculate the multilocus genotype risk score. The case group had a
significantly higher median genotype risk score as compared to the
control group (2.0 vs. 0.0, p< 0.01). Multivariate logistic
regression analysis OSA (dichotomous) as dependent variable and
BMIz score as covariate revealed a significant association between
OSA and total genotype risk score. Conclusions:
We observed an association between polymorphisms involving more
than one gene and OSA in children. Further, a combination of SNPs
of potential biological relevance in OSA pathogenesis predicted OSA
status in children. To our knowledge this is the first report on
use of…
Advisors/Committee Members: Chakraborty, Ranajit (Committee Chair).
Subjects/Keywords: Epidemiology; Sleep apnea; genetic susceptibility
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APA ·
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Manager
APA (6th Edition):
Kalra, M. (2008). Genetic Susceptibility to Obstructive Sleep Apnea in
Children. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226552538
Chicago Manual of Style (16th Edition):
Kalra, Maninder. “Genetic Susceptibility to Obstructive Sleep Apnea in
Children.” 2008. Doctoral Dissertation, University of Cincinnati. Accessed November 15, 2019.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226552538.
MLA Handbook (7th Edition):
Kalra, Maninder. “Genetic Susceptibility to Obstructive Sleep Apnea in
Children.” 2008. Web. 15 Nov 2019.
Vancouver:
Kalra M. Genetic Susceptibility to Obstructive Sleep Apnea in
Children. [Internet] [Doctoral dissertation]. University of Cincinnati; 2008. [cited 2019 Nov 15].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226552538.
Council of Science Editors:
Kalra M. Genetic Susceptibility to Obstructive Sleep Apnea in
Children. [Doctoral Dissertation]. University of Cincinnati; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226552538
University of Hong Kong
6.
Ahrens, Anika.
A randomized clinical trial of the treatment of
obstructive sleep apnoea using oral appliances.
Degree: PhD, 2011, University of Hong Kong
URL: Ahrens,
A..
(2011).
A
randomized
clinical
trial
of
the
treatment
of
obstructive
sleep
apnoea
using
oral
appliances.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b4784959
;
http://dx.doi.org/10.5353/th_b4784959
;
http://hdl.handle.net/10722/174517
► Obstructive sleep apnoea (OSA) is the most common sleep-related breathing disorder and is associated with a range of adverse physical, social and psychological outcomes that…
(more)
▼ Obstructive
sleep apnoea (OSA) is the most
common
sleep-related breathing disorder and is associated with a
range of adverse physical, social and psychological outcomes that
affect quality of life (QoL). Two systematic reviews of the
literature (part of this thesis work) found there is conflicting
evidence of how different mandibular advancement device (MAD)
designs features may affect clinical and subjective OSA outcomes in
certain patients. Therefore, a randomized cross-over trial was
conducted. Firstly, the correlation between clinical OSA indicators
and QOL was explored among patients referred for OSA treatment
using MADs. In addition, associations of OSA risk factors, dental
status and demographic variables with clinical OSA indicators and
QoL indices were determined. Secondly, the efficacy of two
different MADs in the treatment of adult OSA patients was assessed
and compared. Thirdly, the efficacy of the two MADs in the
treatment of adult OSA patients from the subjective perspective of
their bed partners was determined. A consecutive sample of 45
adult OSA patients referred from Queen Mary Hospital
Sleep Centre
to the Prince Philip Dental Hospital for oral appliance therapy was
recruited and treated with a monobloc MAD and a twinblock MADs for
a period of 3 months per MAD (cross-over randomised trial). Changes
in clinical OSA outcomes were assessed by polysomnography (PSG) and
changes in subjective outcomes by the disease-specific
Sleep Apnoea
Quality of Life Index (SAQLI) questionnaire, the Functional Outcome
of
Sleep Questionnaire (FOSQ) and Epworth Sleepiness Scale (ESS).
Patient compliance, side-effects and MAD preference, as well as MAD
treatment impact on the patients’ bed partner was also assessed. At
baseline, some clinical OSA indicators, subjective QoL and certain
OSA risk factors were significantly correlated (p<0.05). There
were significant variations in clinical OSA indicators and
subjective QoL indices with respect to certain risk factors
(p<0.05), demographic variables (p<0.05) and dental status
(p<0.01). There was a significant difference in favour of the
monobloc MAD in terms of improving the apnoea-hypopnoea index (AHI)
(p<0.05) and oxygen desaturation index (ODI) (p<0.01).
Significantly more patients achieved clinical treatment success
with the monobloc compared to the twinblock (p<0.05). Both MADs
were efficacious in improving patients’ SAQLI score (p<0.01),
FOSQ score (p<0.01) and ESS score (p<0.01). Significantly
more patients achieved QoL treatment success with the monobloc
(p<0.05) compared to the twinblock. More patients were ‘very
satisfied’ with the monobloc treatment (p<0.05) and 63%
preferred it to the twinblock. No significant difference was
found between patients’ and bed partners perceptions of symptom
improvement post treatment, however, the monobloc resulted in a
significant reduction in bed partners’ daytime sleepiness
(p<0.01) and allowed significantly more co-sleeping at night
(p<0.05). This study concluded that the monobloc is
superior in improving…
Advisors/Committee Members: McGrath, CPJ, Hagg, EUO.
Subjects/Keywords: Sleep apnea syndromes - Treatment.
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APA ·
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Manager
APA (6th Edition):
Ahrens, A. (2011). A randomized clinical trial of the treatment of
obstructive sleep apnoea using oral appliances. (Doctoral Dissertation). University of Hong Kong. Retrieved from Ahrens, A.. (2011). A randomized clinical trial of the treatment of obstructive sleep apnoea using oral appliances. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4784959 ; http://dx.doi.org/10.5353/th_b4784959 ; http://hdl.handle.net/10722/174517
Chicago Manual of Style (16th Edition):
Ahrens, Anika. “A randomized clinical trial of the treatment of
obstructive sleep apnoea using oral appliances.” 2011. Doctoral Dissertation, University of Hong Kong. Accessed November 15, 2019.
Ahrens, A.. (2011). A randomized clinical trial of the treatment of obstructive sleep apnoea using oral appliances. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4784959 ; http://dx.doi.org/10.5353/th_b4784959 ; http://hdl.handle.net/10722/174517.
MLA Handbook (7th Edition):
Ahrens, Anika. “A randomized clinical trial of the treatment of
obstructive sleep apnoea using oral appliances.” 2011. Web. 15 Nov 2019.
Vancouver:
Ahrens A. A randomized clinical trial of the treatment of
obstructive sleep apnoea using oral appliances. [Internet] [Doctoral dissertation]. University of Hong Kong; 2011. [cited 2019 Nov 15].
Available from: Ahrens, A.. (2011). A randomized clinical trial of the treatment of obstructive sleep apnoea using oral appliances. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4784959 ; http://dx.doi.org/10.5353/th_b4784959 ; http://hdl.handle.net/10722/174517.
Council of Science Editors:
Ahrens A. A randomized clinical trial of the treatment of
obstructive sleep apnoea using oral appliances. [Doctoral Dissertation]. University of Hong Kong; 2011. Available from: Ahrens, A.. (2011). A randomized clinical trial of the treatment of obstructive sleep apnoea using oral appliances. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4784959 ; http://dx.doi.org/10.5353/th_b4784959 ; http://hdl.handle.net/10722/174517
University of Hong Kong
7.
Tsui, Wai-kin.
Mandibular advancement for patients with obstructive
sleep apnea syndrome : a comparison of bilateral mandibular
distraction osteogenesis and bilateral sagittal split
osteotomy.
Degree: PhD, 2016, University of Hong Kong
URL: http://hdl.handle.net/10722/241289
► Maxillomandibular advancement (MMA) is a well-established surgical treatment modality for patients with obstructive sleep apnea (OSA). The advancement of the mandible could be achieved by…
(more)
▼ Maxillomandibular advancement (MMA) is a
well-established surgical treatment modality for patients with
obstructive sleep apnea (OSA). The advancement of the mandible
could be achieved by either bilateral sagittal split osteotomies
(BSSO) or bilateral mandibular distraction osteogenesis (BMDO). It
is very important to know the treatment outcomes, effectiveness,
morbidities and potential complications of both treatments. This
study aims (1) to evaluate the effectiveness and complications of
MDO for treating OSA patients; (2)to compare the airway functions
and skeletal stability of patients treated by BMDO and BSSO; (3) to
assess the changes in airway dimensions brought about by BMDO and
BSSO; (4) to evaluate the clinical morbidities, extent of
neurosensory disturbance and temporomandibular joint functions
associated with BMDO and BSSO; (5)to investigate the effects of
BMDO and BSSO on patients’ facial aesthetics and quality of
life(QoL).
We hope to bridge the knowledge gap on mandibular
advancement in MMA for OSA patientswith the new evidence generated
in this study, and to provide surgeons and OSA patients a
well-informed decision making on the choice of the preferred method
in MMA.
A systematic search on MDO as a treatment for OSA
patients was performed. Mandibular distraction osteogenesis was
shown to be highly effective in resolving OSA in both children and
adults with retrognathic mandible. BMDO wasalso an invaluable means
in alleviating airway obstructions in children in which traditional
orthognathic surgery was deemed impossible
Eighteen subjects with
moderate to severe OSA were recruited in a randomized controlled
trial, allocated in the BMDO and BSSO groupsfor a wide-range
investigation on the 2 methodsfor mandibular advancement in MMA.
Airway functionswere significantly improved in terms of reduction
in apnea/hyponea index and increase lowest oxygen saturation. The
overall success and cure rates of MMA in this study were 88.9% and
61.1% respectively.
Patients treated by BMDO showed significantly
less skeletal relapse with a percentage of 6.7% comparing to 13.6%
in patients treated by BSSO. However, there were minimal clinical
significance brought about by this difference in large advancements
of 10-15mm in this study.
Patientsreceiving BMDO experienced more
morbidities as there were frequent infectionsaround the distractor
rods. There were also 3 cases of bony non-union in this group of
patients, which was an uncommon complication in MMA.
Two groups
of patients hadsimilar degrees of neurosensory disturbance and
associated functional impairment, as well as temporomandibular
joint functions, and all of these reduced to near-normal levels in
long term.
All patients reported improved subjective facial
aesthetics to various extent after MMA. The general-health related
and OSA-specific QoL of both groups of patients were significantly
improved compared to baseline values.
published_or_final_version
Dentistry
Doctoral
Doctor of Philosophy
Subjects/Keywords: Surgery - Sleep apnea syndromes
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APA (6th Edition):
Tsui, W. (2016). Mandibular advancement for patients with obstructive
sleep apnea syndrome : a comparison of bilateral mandibular
distraction osteogenesis and bilateral sagittal split
osteotomy. (Doctoral Dissertation). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/241289
Chicago Manual of Style (16th Edition):
Tsui, Wai-kin. “Mandibular advancement for patients with obstructive
sleep apnea syndrome : a comparison of bilateral mandibular
distraction osteogenesis and bilateral sagittal split
osteotomy.” 2016. Doctoral Dissertation, University of Hong Kong. Accessed November 15, 2019.
http://hdl.handle.net/10722/241289.
MLA Handbook (7th Edition):
Tsui, Wai-kin. “Mandibular advancement for patients with obstructive
sleep apnea syndrome : a comparison of bilateral mandibular
distraction osteogenesis and bilateral sagittal split
osteotomy.” 2016. Web. 15 Nov 2019.
Vancouver:
Tsui W. Mandibular advancement for patients with obstructive
sleep apnea syndrome : a comparison of bilateral mandibular
distraction osteogenesis and bilateral sagittal split
osteotomy. [Internet] [Doctoral dissertation]. University of Hong Kong; 2016. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/10722/241289.
Council of Science Editors:
Tsui W. Mandibular advancement for patients with obstructive
sleep apnea syndrome : a comparison of bilateral mandibular
distraction osteogenesis and bilateral sagittal split
osteotomy. [Doctoral Dissertation]. University of Hong Kong; 2016. Available from: http://hdl.handle.net/10722/241289
University of Hong Kong
8.
賴婉君; Lai, Yuen-kwan, Agnes.
Continuous positive airway pressure education on
adherence in adults with obstructive sleep apnoea.
Degree: Doctor of Nursing, 2013, University of Hong Kong
URL: Lai,
Y.
A.
[賴婉君].
(2013).
Continuous
positive
airway
pressure
education
on
adherence
in
adults
with
obstructive
sleep
apnoea.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5157892
;
http://dx.doi.org/10.5353/th_b5157892
;
http://hdl.handle.net/10722/198849
► Poor adherence to continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnoea (OSA) limits its therapeutic effectiveness and has a major impact…
(more)
▼ Poor adherence to continuous positive airway
pressure (CPAP) treatment in patients with obstructive sleep apnoea
(OSA) limits its therapeutic effectiveness and has a major impact
on clinical outcomes. Effective education programme is important to
enhance CPAP use. However, existing education programmes are either
manpower or resource demanding and may not be feasible in clinical
practice. Moreover, the Self-Efficacy Measure for Sleep Apnoea
(SEMSA) has been widely adopted for assessing adherence-related
cognitions on CPAP therapy in OSA patients, but it was not
available for Chinese.
The aims of this thesis are: (i) to
perform linguistic and psychometric evaluation of a Chinese version
of SEMSA (SEMSA-C); (ii) to examine the efficacy of brief
motivational enhancement education programme in addition to
standard care versus standard care only on improving adherence to
CPAP treatment in patients with OSA.
The SEMSA-C was obtained
after the standard forward-backward translation process. A
randomised controlled trial was then conducted on newly diagnosed
OSA patients. Patients in the control group received standard care
(SC) comprising advice on the importance of CPAP therapy and its
care while those in the intervention group received SC plus
motivational enhancement education programme (ME). ME focused to
enhance subjects’ knowledge, motivation and self-efficacy to use
CPAP, comprising one 45-minute session on the day after CPAP
titration and one 10-minute telephone follow-up shortly after
commencing CPAP treatment. Epworth Sleepiness Scale (ESS), SEMSA-C,
and quality of life were assessed. CPAP usage data were downloaded
at the completion of this 3-month study. The primary outcome was
the CPAP adherence. Furthermore, 21 patients were randomly sampled
at baseline and completed the SEMSA-C at one week.
100 patients
(Men : Women, 84 : 16) with OSA indicated for CPAP treatment were
recruited, with an average age of 52±10 years, and apnoea hypopnoea
index (AHI) of 36.2±22 events/hour. Factor analysis of SEMSA-C
identified three factors: risk perception, outcome expectancies and
treatment self-efficacy. Their corresponding internal consistency
was high with Cronbach’s alpha >0.88, which were larger than all
correlations between subscales (Range: 0.14 to 0.58). The
correlations between items and their hypothesized subscale (Range:
0.58 to 0.85) were generally higher than the correlations between
items and their competing subscales (Range: -0.10 to 0.58).
One-week test-retest intra-class correlation ranged from 0.70 to
0.82. CPAP adherence was associated with outcome expectancies and
treatment self-efficacy at 3-month assessment. Furthermore, SEMSA-C
demonstrated an improvement in self-efficacy (standardised response
mean = 0.33, p = .044) but no significant changes were observed in
the other two factors, after CPAP use.
The 100 patients were
followed for 3 months. The interventional effects maintained during
the 3-month study period. There were a better CPAP use [higher
daily CPAP usage of 2 hours/day (Cohen d =…
Subjects/Keywords: Sleep apnea syndromes - Treatment
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Manager
APA (6th Edition):
賴婉君; Lai, Yuen-kwan, A. (2013). Continuous positive airway pressure education on
adherence in adults with obstructive sleep apnoea. (Doctoral Dissertation). University of Hong Kong. Retrieved from Lai, Y. A. [賴婉君]. (2013). Continuous positive airway pressure education on adherence in adults with obstructive sleep apnoea. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5157892 ; http://dx.doi.org/10.5353/th_b5157892 ; http://hdl.handle.net/10722/198849
Chicago Manual of Style (16th Edition):
賴婉君; Lai, Yuen-kwan, Agnes. “Continuous positive airway pressure education on
adherence in adults with obstructive sleep apnoea.” 2013. Doctoral Dissertation, University of Hong Kong. Accessed November 15, 2019.
Lai, Y. A. [賴婉君]. (2013). Continuous positive airway pressure education on adherence in adults with obstructive sleep apnoea. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5157892 ; http://dx.doi.org/10.5353/th_b5157892 ; http://hdl.handle.net/10722/198849.
MLA Handbook (7th Edition):
賴婉君; Lai, Yuen-kwan, Agnes. “Continuous positive airway pressure education on
adherence in adults with obstructive sleep apnoea.” 2013. Web. 15 Nov 2019.
Vancouver:
賴婉君; Lai, Yuen-kwan A. Continuous positive airway pressure education on
adherence in adults with obstructive sleep apnoea. [Internet] [Doctoral dissertation]. University of Hong Kong; 2013. [cited 2019 Nov 15].
Available from: Lai, Y. A. [賴婉君]. (2013). Continuous positive airway pressure education on adherence in adults with obstructive sleep apnoea. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5157892 ; http://dx.doi.org/10.5353/th_b5157892 ; http://hdl.handle.net/10722/198849.
Council of Science Editors:
賴婉君; Lai, Yuen-kwan A. Continuous positive airway pressure education on
adherence in adults with obstructive sleep apnoea. [Doctoral Dissertation]. University of Hong Kong; 2013. Available from: Lai, Y. A. [賴婉君]. (2013). Continuous positive airway pressure education on adherence in adults with obstructive sleep apnoea. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5157892 ; http://dx.doi.org/10.5353/th_b5157892 ; http://hdl.handle.net/10722/198849
University of Florida
9.
Mundt, Jennifer M.
An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders.
Degree: PhD, Psychology - Clinical and Health Psychology, 2017, University of Florida
URL: http://ufdc.ufl.edu/UFE0050826
► Short sleep duration and insomnia have been linked to higher pain and an increased risk of developing chronic pain, but relatively little research has examined…
(more)
▼ Short
sleep duration and insomnia have been linked to higher pain and an increased risk of developing chronic pain, but relatively little research has examined the contribution of
sleep disordered breathing (SDB) to pain. This study examined the unique contributions of SDB and insomnia to chronic pain. Patients who presented to the University of Florida Health
Sleep Center for overnight polysomnography were invited to participate, provided they had no history of using positive airway pressure. Participants (N = 105) completed additional questionnaires about their
sleep (Insomnia Severity Index) and pain (Medical College of Virginia Pain Questionnaire, pain locations, chronic pain diagnoses) before undergoing overnight polysomnography. They subsequently completed an online
sleep/pain diary for two weeks. Physicians diagnosed 52.38% with obstructive
sleep apnea (OSA) and 4.76% with insomnia, though 20.95% were classified as having chronic insomnia based on
sleep diaries used for the study. In a hierarchical regression, polysomnography-measured total
sleep time, but not measures of
sleep fragmentation (
apnea-hypopnea index, spontaneous arousals) or hypoxemia (SaO2 nadir), was related to pain. The majority of participants
Advisors/Committee Members: ROBINSON,MIKE E (committee chair), DOTSON,VONETTA M (committee member), EBNER,NATALIE CHRISTINA (committee member).
Subjects/Keywords: apnea – insomnia – pain – polysomnography – sleep
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APA (6th Edition):
Mundt, J. M. (2017). An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0050826
Chicago Manual of Style (16th Edition):
Mundt, Jennifer M. “An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders.” 2017. Doctoral Dissertation, University of Florida. Accessed November 15, 2019.
http://ufdc.ufl.edu/UFE0050826.
MLA Handbook (7th Edition):
Mundt, Jennifer M. “An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders.” 2017. Web. 15 Nov 2019.
Vancouver:
Mundt JM. An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders. [Internet] [Doctoral dissertation]. University of Florida; 2017. [cited 2019 Nov 15].
Available from: http://ufdc.ufl.edu/UFE0050826.
Council of Science Editors:
Mundt JM. An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders. [Doctoral Dissertation]. University of Florida; 2017. Available from: http://ufdc.ufl.edu/UFE0050826
University of Sydney
10.
Rowsell, Luke Joshua.
The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
.
Degree: 2016, University of Sydney
URL: http://hdl.handle.net/2123/16441
► This thesis aims to evaluate the effect of 40mg oral slow release morphine on obstructive sleep apnea (OSA) and awake ventilatory chemoreflexes in 60 OSA…
(more)
▼ This thesis aims to evaluate the effect of 40mg oral slow release morphine on obstructive sleep apnea (OSA) and awake ventilatory chemoreflexes in 60 OSA men in a randomised, double-blind placebo controlled crossover study. The study attempts to phenotype and genotype the potentially large variability of OSA response to a common dose of morphine using cutting edge techniques.
We found that morphine caused mild respiratory depression but did not affect the percent of TST spent below 90% oxygen saturation (T90), nor apnea-hypopnea index (AHI). However, large inter-individual variability was observed. Morphine tended to improve T90 in A/G vs A/A OPRM1 genotype subjects. 2. Morphine reduced slow wave sleep and rapid eye movement (REM) sleep overall, however did not attenuate REM sleep in subjects with (CT + TT) vs CC HTR3B genotype. Total sleep time (TST) increased following morphine in C/C vs (C/T + T/T) ABCB1 genotype subjects only. 3. CO2 ventilatory recruitment threshold (VRT) was increased and hypercapnic/hypoxic ventilatory response (HCVR/HVR) was depressed overall. HCVR depression following morphine was greater in A/G vs A/A OPRM1 subjects, and C/C vs (C/T + T/T) ABCB1 subjects. 4. A mechanism by which morphine may improve OSA in some OSA patients through reducing chemosensitivity and widening CO2 reserve was proposed. 5. Negative linear relationships were found in severe OSA patients between baseline VRT and morphine effect on AHI, oxygen desaturation index, arousal index and T90. 6. Subjects with extreme improvement in T90 following morphine were older, had higher VRT and were often A/G OPRM1 genotype compared to those with greatest deterioration.
In conclusion, 40mg morphine on average only caused mild respiratory depression but with a large variability in men with OSA. The large inter-individual variability may be partly explained by baseline awake chemoreflexes. Certain genotypes associated with differential morphine effect on OSA were identified.
Subjects/Keywords: obstructive sleep apnea;
opoids;
morphine
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APA (6th Edition):
Rowsell, L. J. (2016). The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/16441
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rowsell, Luke Joshua. “The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
.” 2016. Thesis, University of Sydney. Accessed November 15, 2019.
http://hdl.handle.net/2123/16441.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rowsell, Luke Joshua. “The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
.” 2016. Web. 15 Nov 2019.
Vancouver:
Rowsell LJ. The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
. [Internet] [Thesis]. University of Sydney; 2016. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/2123/16441.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rowsell LJ. The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
. [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/16441
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Delft University of Technology
11.
Maassen, M.B.J.M.
Increasing user comfort in the treatment of obstructive sleep apnoea:.
Degree: 2011, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:04a949ee-c0b8-4dc0-a7bb-ef7e58494f40
► This report address the master graduation project of Michiel Maassen titled: “Increasing user comfort in the treatment for obstructive sleep apnoea” OSA (Obstructive Sleep apnoea)…
(more)
▼ This report address the master graduation project of Michiel Maassen titled:
“Increasing user comfort in the treatment for obstructive
sleep apnoea”
OSA (Obstructive
Sleep apnoea) is a
sleep disorder which effects 3-4% of the male and 2% of the female population. A blockage in the throat, caused by relaxation of the tongue, makes patients repeatedly stop breathing for over ten seconds during
sleep. This can happen over thirty times an hour. A major problem of OSA is that patients are unaware of its existence; symptoms may be present for years without identification. Untreated OSA causes insomnia, higher blood pressure, oxygen shortage and triples the chance of fatal heart failure. It also causes a huge economic burden, since the medical cost of an untreated OSA patient are almost double compared to the general population. Next to that, indirect costs are substantial. For example, OSA patients have a three- to sevenfold increased risk of motor vehicle crashes.
The most common treatment for OSA is Continuous Positive Airway Pressure (CPAP). This is a machine that supplies pressurized air to the user via a hose and a mask to prevent apnoea’s during
sleep. Although CPAP is improved in its 30 year existence, no fundamental changes have been made next to adding variable pressure and humidification. The treatment is very effective but still not very comfortable; 72% of the users suffer from problems and side effects. That is why one out of three patients quits the treatment, which reduces the life expectancy of the patient drastically. The discomfort is mainly caused by the mask of the CPAP device.
Within Philips, CPAP belongs to the home healthcare sector, which is marked as core of healthcare division and a key focus for the company in general. Philips would benefit greatly of an improved version of the CPAP machine that reduces the discontinue rate of the current treatment. At the moment Philips Respironics is a major player in the CPAP market, but it is not the largest and their products are, compared to the main competition, priced below average. A new innovative high end product or product line in this market can be the example for the Philips Respironics brand to move towards a higher market segment.
In the graduation project a new treatment for OSA is developed, according to the design methodology of the faculty of Industrial Design Engineering at the Delft University of Technology. During the development the student had access to state of the art research facilities that are present within Philips Research. Based on papers, patens, users, numerous experiments and computer simulations an insight was gained in the difficulties, problems and imperfections of the current treatment. The main problem is the lack of comfort which is mostly caused by the current mask that causes irritation on the skin. New solutions were proposed during various design iterations, of which three invention disclosure have been filled to the Philips patent office which evaluated if the intellectual property was eligible for protection.…
Advisors/Committee Members: Goossens, R.H.M., Hajian, M..
Subjects/Keywords: Obstructive Sleep Apnoea; CPAP; Apnea
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to Zotero / EndNote / Reference
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APA (6th Edition):
Maassen, M. B. J. M. (2011). Increasing user comfort in the treatment of obstructive sleep apnoea:. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:04a949ee-c0b8-4dc0-a7bb-ef7e58494f40
Chicago Manual of Style (16th Edition):
Maassen, M B J M. “Increasing user comfort in the treatment of obstructive sleep apnoea:.” 2011. Masters Thesis, Delft University of Technology. Accessed November 15, 2019.
http://resolver.tudelft.nl/uuid:04a949ee-c0b8-4dc0-a7bb-ef7e58494f40.
MLA Handbook (7th Edition):
Maassen, M B J M. “Increasing user comfort in the treatment of obstructive sleep apnoea:.” 2011. Web. 15 Nov 2019.
Vancouver:
Maassen MBJM. Increasing user comfort in the treatment of obstructive sleep apnoea:. [Internet] [Masters thesis]. Delft University of Technology; 2011. [cited 2019 Nov 15].
Available from: http://resolver.tudelft.nl/uuid:04a949ee-c0b8-4dc0-a7bb-ef7e58494f40.
Council of Science Editors:
Maassen MBJM. Increasing user comfort in the treatment of obstructive sleep apnoea:. [Masters Thesis]. Delft University of Technology; 2011. Available from: http://resolver.tudelft.nl/uuid:04a949ee-c0b8-4dc0-a7bb-ef7e58494f40
The Ohio State University
12.
Maerz, Rachael Jean, Maerz.
Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study.
Degree: MS, Dentistry, 2018, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596
► Objectives: Sleep apnea is a common chronic condition, with prevalence estimated at approximately 26% and 13% of adult males and females, respectively. The consequence of…
(more)
▼ Objectives:
Sleep apnea is a common chronic condition,
with prevalence estimated at approximately 26% and 13% of adult
males and females, respectively. The consequence of untreated OSA
is increased morbidity and mortality. Long-term adherence to
treatment for chronic conditions in developed countries is
estimated at 50%. The aim of this study was to test whether a
multifactorial intervention in addition to the standard of care
increases adherence rates in patients using a titratable oral
appliance to treat OSA.Methods: Subjects are between the ages of
18-60+, and have a diagnosis of OSA. After informed consent, they
were assigned at random to the experimental or control group. A
power analysis indicated group size of 30 subjects each was
necessary to demonstrate a difference in the three variables
(p<0.05) of +/- 15% between groups with a power of 0.86. The
control group received routine care. Experimental subjects received
in addition: educational material at scheduled intervals,
spouse/partner packet, monthly follow up communication,
communication with primary physician and dentist about patients,
printouts of sensor data, and gift cards for timely follow up with
sleep physician. Comparison of adherence was at 1-, 3-, and 6 month
time points. Variables were: mean nights of appliance wear, mean
nights adherent to prescribed wear time, mean nights worn per week,
and the mean hours worn per night.Results: Forty subjects have been
enrolled to date, 15 females and 25 males. Seventeen have been
recorded at time point one (30 days). Seven subjects have left the
study and there have been 5 sensor malfunctions (patients
continuing to use appliance in the absence of objective
monitoring). There were no significant differences between group
for gender, age, and BMI at time point 1. There were no significant
differences between groups for total nights worn, total nights
adherent, number of nights/week, and hours/night for time points
1.Conclusions: The interventions were well received by the
subjects, and most of the repeated interventions could be carried
out by administrative personnel. There was a significant failure
rate with the sensors that added a level of frustration to the
process. There were no statistical differences for total nights
worn, total nights adherent, number of nights/week, or hrs/night.
This may be due to inadequate sample size. The means for all
variables were higher in the experimental group compared with the
control group.
Advisors/Committee Members: Firestone, Allen (Advisor).
Subjects/Keywords: Dentistry; adherence, sleep apnea
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Manager
APA (6th Edition):
Maerz, Rachael Jean, M. (2018). Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596
Chicago Manual of Style (16th Edition):
Maerz, Rachael Jean, Maerz. “Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study.” 2018. Masters Thesis, The Ohio State University. Accessed November 15, 2019.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596.
MLA Handbook (7th Edition):
Maerz, Rachael Jean, Maerz. “Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study.” 2018. Web. 15 Nov 2019.
Vancouver:
Maerz, Rachael Jean M. Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study. [Internet] [Masters thesis]. The Ohio State University; 2018. [cited 2019 Nov 15].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596.
Council of Science Editors:
Maerz, Rachael Jean M. Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study. [Masters Thesis]. The Ohio State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596
Harvard University
13.
Shin, Christina.
The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications.
Degree: Doctor of Medicine, 2016, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215
► Purpose: Postoperative respiratory complications (PRCs) are associated with significant morbidity, mortality, and costs. Obstructive sleep apnea (OSA), which is often undiagnosed in the surgical population,…
(more)
▼ Purpose: Postoperative respiratory complications (PRCs) are associated with significant morbidity, mortality, and costs. Obstructive sleep apnea (OSA), which is often undiagnosed in the surgical population, may be a contributing factor.
Methods: We conducted an observational study of adult surgical patients at Partners HealthCare hospitals (2007-2014) using electronic patient and perioperative data. OSA was defined as the occurrence of an OSA diagnostic code preceded by a polysomnography procedure code. A priori defined variables were analyzed by multivariable logistic regression analysis to develop our score. Score validity was assessed by investigating the score’s ability to predict noninvasive ventilation. Following the development of our Score for Preoperative Prediction of Obstructive Sleep Apnea (SPOSA), we assessed the effect of high OSA risk on our primary outcome, PRCs within seven postoperative days. In order to improve the clinical utility of the score, a dichotomized OSA risk scale was developed using the SPOSA cut point of 7. Propensity score matched cohorts were used to understand patient and health care outcomes among patients identified as high risk for OSA.
Results: Predictors for OSA included BMI >25 kg/m2 and comorbidities, including hypertension, diabetes, and dyslipidemia. The score yielded an area under the curve of 0.81. Inclusion of early postoperative desaturation did not improve the score. Noninvasive ventilation was significantly associated with high OSA risk (odds ratio 1.45, 95% confidence interval 1.20-1.76, p<0.001), confirming the validity of the SPOSA. Using a dichotomized endpoint, 29,087 patients were identified as high risk for OSA and 7.7% of these patients experienced PRCs. OSA risk was significantly associated with PRCs (OR 1.38, 95% CI 1.1.26-1.51, p<0.001). High OSA risk was also significantly associated with increased postoperative length of stay, increased total costs of care, and higher rates of admission to the intensive care unit, adverse discharge, and readmission within 30 days of initial discharge.
Conclusions: The SPOSA assesses OSA risk and predicts the occurrence of respiratory complications. High OSA risk is associated with adverse clinical and care outcomes. Utilization of the SPOSA will allow providers to risk stratify patients prior to admission and may help reduce perioperative consequences of OSA.
Scholarly Project
Subjects/Keywords: Obstructive sleep apnea; respiratory complications
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Manager
APA (6th Edition):
Shin, C. (2016). The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215
Chicago Manual of Style (16th Edition):
Shin, Christina. “The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications.” 2016. Doctoral Dissertation, Harvard University. Accessed November 15, 2019.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215.
MLA Handbook (7th Edition):
Shin, Christina. “The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications.” 2016. Web. 15 Nov 2019.
Vancouver:
Shin C. The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications. [Internet] [Doctoral dissertation]. Harvard University; 2016. [cited 2019 Nov 15].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215.
Council of Science Editors:
Shin C. The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications. [Doctoral Dissertation]. Harvard University; 2016. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215
Queens University
14.
Pang, Helen Wai Kiu.
Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
.
Degree: Physiology, 2011, Queens University
URL: http://hdl.handle.net/1974/6625
► Background: Obstructive sleep apnea (OSA) has been associated with atrial enlargement in response to high arterial and pulmonary pressures and increased sympathetic tone. Continuous positive…
(more)
▼ Background: Obstructive sleep apnea (OSA) has been associated with atrial enlargement in response to high arterial and pulmonary pressures and increased sympathetic tone. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; its impact on atrial electrical remodeling has not been investigated however. Signal-averaged p-wave (SAPW) is a non-invasive quantitative method to determine p-wave duration, an accepted marker for atrial electrical remodeling. The objective was to determine whether CPAP induces reverse atrial electrical remodeling in patients with severe OSA.
Methods: Prospective study in consecutive patients attending the Sleep Clinic at Kingston General Hospital. All patients underwent full polysomnography. OSA-negative and severe OSA were defined as apnea-hypopnea index (AHI) < 5 events/hour and AHI ≥ 30 events/hour, respectively. In severe OSA patients, SAPW was determined pre- and post-intervention with CPAP for 4 - 6 weeks. In OSA-negative controls, SAPW was recorded at baseline and 4 - 6 weeks thereafter without any intervention.
Results: A total of 19 severe OSA patients and 10 controls were included in the analysis. Mean AHI and minimum O2 saturation were 41.4 ± 10.1 events/hour and 80.5 ± 6.5% in severe OSA patients and 2.8 ± 1.2 events/hour and 91.4 ± 2.1% in controls. Baseline BMI was different between severe OSA patients and controls (34.3 ± 5.4 vs 26.6 ± 4.6 kg/m2; p < 0.001). At baseline, severe OSA patients had a greater SAPW duration than controls (131.9 ± 10.4 vs 122.8 ± 10.5 ms; p = 0.02). After CPAP intervention, there was a significant reduction of SAPW duration in severe OSA (131.9 ± 10.4 to 126.2 ± 8.8 ms; p < 0.001). In controls, SAPW duration did not change within 4 - 6 weeks.
Conclusion: CPAP induced reverse atrial electrical remodeling in patients with severe OSA as represented by a significant reduction in SAPW duration.
Subjects/Keywords: atrial remodeling;
obstructive sleep apnea
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APA (6th Edition):
Pang, H. W. K. (2011). Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6625
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pang, Helen Wai Kiu. “Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
.” 2011. Thesis, Queens University. Accessed November 15, 2019.
http://hdl.handle.net/1974/6625.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pang, Helen Wai Kiu. “Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
.” 2011. Web. 15 Nov 2019.
Vancouver:
Pang HWK. Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
. [Internet] [Thesis]. Queens University; 2011. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/1974/6625.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pang HWK. Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
. [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6625
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Arizona
15.
Sweeney, Nathan.
Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/628049
► Primary liver cancer is the seventh most common cancer worldwide and the second highest cause of cancer mortality. The incidence of hepatocellular carcinoma (HCC) has…
(more)
▼ Primary liver cancer is the seventh most common cancer worldwide and the second highest cause of cancer mortality. The incidence of hepatocellular carcinoma (HCC) has increased 80% in the past two decades and now comprises 85% of all primary liver cancer. Obesity increases the risk of developing HCC two-fold in women and five-fold in men. Co-morbidities common to obesity including non-alcoholic steatohepatitis (NASH), hepatic inflammation, and lipid accumulation increase the risk of developing HCC. Obstructive
sleep apnea (OSA), a state of chronic intermittent hypoxia which is common in obese individuals, also increases the incidence of NASH. With a U.S. population that is approximately 33% obese, having OSA at 30-50%, we estimate the co-incidence of obesity and OSA is 10-16.5% of the entire U.S. population. Diet-induced obesity or intermittent hypoxia induces hepatic lipid accumulation and diet-induced obesity was recently shown to promote HCC tumor development. Whether obesity, chronic intermittent hypoxia, and their combination hasten hepatic lipid accumulation and HCC tumor progression remains unclear. In our studies, we monitored tumor development utilizing micro-computed tomography imaging and discovered that tumors developed fastest in mice that consumed a high fat diet. Upon further investigation, these mice also tended to have higher serum levels of AST and ALT and gained more weight than their counterparts. However, the addition of hypoxia lead to a decrease in weight gained, as well as a reduction in hepatic lipid accumulation and tumor formation. Extraction of mRNA from mouse livers revealed an up-regulation HIF-1α in mice fed a high fat diet without treatment with hypoxia that correlated strongly with tumorigenesis. Remarkably, hypoxia was found in mice treated with hypoxia as well as the mice that were fed a high fat diet only. These findings suggest that hepatic lipid accumulation produces endogenous hepatic hypoxia which associates with increased hepatic HIF-1α expression that correlates with tumorigenesis. Collectively, these data reveal a mechanism that potentially explains progression from early liver disease to HCC.
Advisors/Committee Members: Martinez, Jesse (advisor), Breihl, Margaret (committeemember), Cherrington, Nathan (committeemember), Doetschman, Tom (committeemember), Tax, Frans (committeemember).
Subjects/Keywords: Liver Cancer;
Obesity;
Sleep Apnea
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APA (6th Edition):
Sweeney, N. (2018). Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/628049
Chicago Manual of Style (16th Edition):
Sweeney, Nathan. “Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
.” 2018. Doctoral Dissertation, University of Arizona. Accessed November 15, 2019.
http://hdl.handle.net/10150/628049.
MLA Handbook (7th Edition):
Sweeney, Nathan. “Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
.” 2018. Web. 15 Nov 2019.
Vancouver:
Sweeney N. Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
. [Internet] [Doctoral dissertation]. University of Arizona; 2018. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/10150/628049.
Council of Science Editors:
Sweeney N. Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
. [Doctoral Dissertation]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/628049
Brno University of Technology
16.
Vrana, Vojtěch.
Detekce spánkové apnoe u dospělých pacientů
.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/173608
► Cílem této práce je konstrukce zařízení detekující apnoické dýchací pauzy během spánku. Nejčastější příčinou apnoických pauz je obstrukce dýchacích cest, např. kolapsem dýchacích cest. Apnoe…
(more)
▼ Cílem této práce je konstrukce zařízení detekující apnoické dýchací pauzy během spánku. Nejčastější příčinou apnoických pauz je obstrukce dýchacích cest, např. kolapsem dýchacích cest. Apnoe vede k zhoršení kvality spánku a zvyšuje riziko kardiovaskulárních onemocnění. Kontrolér je konstruován na vývojové desce Arduino Uno. Celá měřící aparatura se skládá za dvou obvodů pro měření vnějších projevů pohybu dýchacích svalů a mikrofonu, na měření přítomnosti proudu vzduchu.; The goal of this work is to construct a device detecting apneic respiration pauses during
sleep. The most common cause of
apnea pauses is obstruction of the airways, eg, airway collapse.
Apnea leads to a deterioration in the quality of
sleep and increases the risk of cardiovascular disease. The controller is designed on the Arduino Uno development board. The whole measuring device consists of two circuits for measuring the external manifestations of movement of respiratory muscles and a microphone for measuring the presence of air flow.
Advisors/Committee Members: Sekora, Jiří (advisor).
Subjects/Keywords: Kontrolér spánkové apnoe;
spánková apnoe;
spánek;
Arduino;
Sleep Apnea Controller;
Sleep Apnea;
Sleep;
Arduino
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APA ·
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APA (6th Edition):
Vrana, V. (2019). Detekce spánkové apnoe u dospělých pacientů
. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/173608
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vrana, Vojtěch. “Detekce spánkové apnoe u dospělých pacientů
.” 2019. Thesis, Brno University of Technology. Accessed November 15, 2019.
http://hdl.handle.net/11012/173608.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vrana, Vojtěch. “Detekce spánkové apnoe u dospělých pacientů
.” 2019. Web. 15 Nov 2019.
Vancouver:
Vrana V. Detekce spánkové apnoe u dospělých pacientů
. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/11012/173608.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vrana V. Detekce spánkové apnoe u dospělých pacientů
. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/173608
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Alberta
17.
Lau, Amanda A.
Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study.
Degree: MS, Department of Public Health Sciences, 2014, University of Alberta
URL: https://era.library.ualberta.ca/files/c5138jd94j
► Inadequate childhood sleep may adversely affect neurodevelopment, behaviour, and metabolic function. Few population-based studies have examined sleep duration and sleep disordered breathing (SDB) within the…
(more)
▼ Inadequate childhood sleep may adversely affect
neurodevelopment, behaviour, and metabolic function. Few
population-based studies have examined sleep duration and sleep
disordered breathing (SDB) within the first year of life. Families
in the Edmonton site of the Canadian Healthy Infant Longitudinal
Development (CHILD) birth cohort study completed sleep
questionnaires (Pediatric Sleep Questionnaires (PSQ) and Brief
Infant Sleep Questionnaire (BISQ)), and questionnaires related to
child health, environmental/household exposures, and parental
health, stress, and sleep when their child was 3, 6, 9, and 12
months of age. The association between self-soothing and sleep
duration (i.e. total amount of sleep during day and night as
reported on the BISQ) was analyzed longitudinally with multivariate
linear regression using generalized estimating equations (GEE)
methods with exchangeable correlation matrix and robust errors.
Infant sleep was also analyzed cross-sectionally when the child was
3, 6, 9, 12 months of age using multivariable linear regression.
The association between BMI Z-Scores and SDB (i.e. answering
positively to more than 1/3 of the PSQ questions or a PSQ score of
0.33 or greater) was analyzed with cox proportional hazard
modeling. The earliest PSQ score of 0.33 or greater was used to
define time to SDB. Follow-up started at birth and data was
censored at 12 months of age if the infant did not have SDB or at
the child’s age if and when loss to follow up occurred. In an
additional analysis, PSQ questions relating to rhinitis were
excluded and added in the multivariate model to investigate the
association between rhinitis and SDB. Of the 845 Edmonton CHILD
participants, 765 had sleep duration data. Sleep duration was
inversely associated with age. On average, infants slept 14.08
hours at 3 months, 13.66 hours at 6 months, 13.41 hours at 9
months, and 13.51 hours at 12 months of age. Non self-soothing was
consistently associated with shorter sleep duration in longitudinal
and cross-sectional analyses. A multivariate longitudinal analysis
stratified by birth order was performed. Self-soothing infants
(-0.31 hours; 95% Confidence Interval (95%CI) -0.51, -0.11;
p<0.001 for first-born; -0.57 hours; 95%CI -0.76, -0.37;
p<0.001 for subsequent-born), sleep times after 21:00 (-0.67
hours; 95%CI -0.86, -0.45; p<0.001 for first-born; -0.61
hours; 95%CI -0.81, -0.42; p<0.001 for subsequent-born), and
a parent who perceived their child’s sleep as a small problem
(-0.62 hours; 95%CI -0.84, -0.40; p<0.001 for first-born;
-0.86 hours; 95%CI -1.08, -0.65; p<0.001 for
subsequent-born) and very serious problem (-2.19 hours; 95%CI
-3.00, -1.38; p<0.001 for first-born; -1.91 hours; 95%CI
-2.52, -1.31; p<0.001 for subsequent-born) were
significantly associated with shorter sleep duration in first-born
and subsequent-born infants. A child’s age was significantly
associated with shorter sleep duration in subsequent-born infants
but not first-born infants. In subsequent-born infants, infants
that were fed only…
Subjects/Keywords: pediatric; sleep duration; birth cohort; sleep disordered breathing; sleep apnea
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Manager
APA (6th Edition):
Lau, A. A. (2014). Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c5138jd94j
Chicago Manual of Style (16th Edition):
Lau, Amanda A. “Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study.” 2014. Masters Thesis, University of Alberta. Accessed November 15, 2019.
https://era.library.ualberta.ca/files/c5138jd94j.
MLA Handbook (7th Edition):
Lau, Amanda A. “Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study.” 2014. Web. 15 Nov 2019.
Vancouver:
Lau AA. Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2019 Nov 15].
Available from: https://era.library.ualberta.ca/files/c5138jd94j.
Council of Science Editors:
Lau AA. Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/c5138jd94j
University of Alberta
18.
Altalibi, Mostafa.
Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists.
Degree: MS, Medical Sciences-Orthodontics, 2015, University of Alberta
URL: https://era.library.ualberta.ca/files/c02870v88m
► Purpose: To develop a physician screening index for the oral and facial assessment of the orthodontic treatment-need in pediatric patients with Obstructive Sleep Apnea (OSA)…
(more)
▼ Purpose: To develop a physician screening index for
the oral and facial assessment of the orthodontic treatment-need in
pediatric patients with Obstructive Sleep Apnea (OSA) that may
diminish the severity of their OSA symptoms. Methods: Based on the
available literature and WHO guidelines for index development, a
draft index was produced, and subjected to multiple iterative
revisions based on the feedback from: 1) the Index Development
Group; 2) the External Review Group; and 3) the Steering Committee.
Once the index was formalized, it was subjected to reliability
testing Results: Based on the feedback from the Index Development
Group, the External Review Group and the Steering Committee, an
index has been developed that is simple, easy to understand and
easy to use. The index also exhibits a fair to substantial
inter-rater reliability, and moderate to almost perfect intra-rater
reliability. The orthodontic residents scored better than the
medical residents in the reliability tests and took less time to
use the index. The average time to use the index on 15 cases was
17:14min. Conclusions: This is a much needed, simple, and easy to
use index that is reliable among orthodontic residents and among
medical residents.
Subjects/Keywords: Index; Physician; Obstructive Sleep Apnea; Orthodontics
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APA (6th Edition):
Altalibi, M. (2015). Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c02870v88m
Chicago Manual of Style (16th Edition):
Altalibi, Mostafa. “Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists.” 2015. Masters Thesis, University of Alberta. Accessed November 15, 2019.
https://era.library.ualberta.ca/files/c02870v88m.
MLA Handbook (7th Edition):
Altalibi, Mostafa. “Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists.” 2015. Web. 15 Nov 2019.
Vancouver:
Altalibi M. Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists. [Internet] [Masters thesis]. University of Alberta; 2015. [cited 2019 Nov 15].
Available from: https://era.library.ualberta.ca/files/c02870v88m.
Council of Science Editors:
Altalibi M. Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists. [Masters Thesis]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/c02870v88m
University of Alberta
19.
Collinson, Mary O.
Living with sleep Apnea at work, home and leisure: a
phenomenological study.
Degree: MEd, Department of Educational Psychology, 1995, University of Alberta
URL: https://era.library.ualberta.ca/files/2j62s689p
Subjects/Keywords: Sleep apnea syndromes.
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Manager
APA (6th Edition):
Collinson, M. O. (1995). Living with sleep Apnea at work, home and leisure: a
phenomenological study. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2j62s689p
Chicago Manual of Style (16th Edition):
Collinson, Mary O. “Living with sleep Apnea at work, home and leisure: a
phenomenological study.” 1995. Masters Thesis, University of Alberta. Accessed November 15, 2019.
https://era.library.ualberta.ca/files/2j62s689p.
MLA Handbook (7th Edition):
Collinson, Mary O. “Living with sleep Apnea at work, home and leisure: a
phenomenological study.” 1995. Web. 15 Nov 2019.
Vancouver:
Collinson MO. Living with sleep Apnea at work, home and leisure: a
phenomenological study. [Internet] [Masters thesis]. University of Alberta; 1995. [cited 2019 Nov 15].
Available from: https://era.library.ualberta.ca/files/2j62s689p.
Council of Science Editors:
Collinson MO. Living with sleep Apnea at work, home and leisure: a
phenomenological study. [Masters Thesis]. University of Alberta; 1995. Available from: https://era.library.ualberta.ca/files/2j62s689p
NSYSU
20.
Wang, Jen-feng.
AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information.
Degree: PhD, Mechanical and Electro-Mechanical Engineering, 2009, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820
► The diagnosis of obstructive sleep apnea (OSA) syndrome is overnight PSG (mutli-channel system). But itâs hard to be popularized for the general population (about twenty…
(more)
▼ The diagnosis of obstructive
sleep apnea (OSA) syndrome is overnight PSG (mutli-channel system). But itâs hard to be popularized for the general population (about twenty channel signals). In recent decades, several researches were devoted to a replacement system with only one channel signal (oxyhemoglobin saturation). However, itâs hard to match PSG systemâs report without EEG wake information. Consequently, two channels (oxyhemoglobin saturation and EEG) were used of this study to enhance the AHI (estimation index for
sleep apnea) prediction performance. After surveying the most recent studies, this work proposes a new basleline removal technique for oxygen saturation signal (SpO2) by using median filter. It was proved this technique improves the diagnostic accuracy for OSA. Furthermore, it is also found that by removing the wake periods, diagnostic accuracy can be improved further.
By counting the number of times that the desaturation level has dropped more than 2% for at least 3 seconds, the correlation coefficient between AHI and proposed feature is 0.9218. In addition, by removing the wake period, this correlation increases to 0.9425. By using this feature to classify patients with AHI value larger than 5, the proposed approach achieves 93.78% accuracy, 95.94% sensitivity, 78.87% specificity f. Such results demonstrate the feasibility of using single SpO2 channel system for OSA diagnosis.
Advisors/Committee Members: Jau-Wei Perng (chair), Pei-Chung Chen (chair), Chen-Wen Yen (committee member), Wei-Huang Lin (chair), Yaw-Terng Su (chair).
Subjects/Keywords: Obstructive sleep apnea syndrome; Oxyhemoglobin saturation
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Manager
APA (6th Edition):
Wang, J. (2009). AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820
Chicago Manual of Style (16th Edition):
Wang, Jen-feng. “AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information.” 2009. Doctoral Dissertation, NSYSU. Accessed November 15, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820.
MLA Handbook (7th Edition):
Wang, Jen-feng. “AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information.” 2009. Web. 15 Nov 2019.
Vancouver:
Wang J. AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information. [Internet] [Doctoral dissertation]. NSYSU; 2009. [cited 2019 Nov 15].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820.
Council of Science Editors:
Wang J. AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information. [Doctoral Dissertation]. NSYSU; 2009. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820
Georgia State University
21.
McArthur, Dedria.
Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients.
Degree: MPH, Public Health, 2016, Georgia State University
URL: https://scholarworks.gsu.edu/iph_theses/469
► Background: Obstructive Sleep Apnea (OSA) is a chronic breathing disorder that is estimated to affect 20% of the US adult population. Intermittent hypoxia and…
(more)
▼ Background: Obstructive
Sleep Apnea (OSA) is a chronic breathing disorder that is estimated to affect 20% of the US adult population. Intermittent hypoxia and
sleep fragmentation caused by OSA likely affects cardiometabolic function. Individuals with OSA might be at risk of developing hypertension and type 2 diabetes (T2DM), with a dose-response relationship related to OSA severity. The objective of this study was to estimate the association between severity of OSA at diagnosis with 1) incidence of hypertension incidence of hypertension and 2) incidence of T2DM.
Methods: We conducted a retrospective cohort study of Kaiser Permanente members diagnosed with OSA during 2000-2005. Adults without baseline hypertension or T2DM were eligible. Patients were excluded if hypertension or T2DM was diagnosed within one year prior to OSA diagnosis, and right censored at the end of follow-up or at the time Kaiser Permanente membership ended. Kaplan-Meier curves and Cox Proportional Hazard models were used to estimate the association between OSA severity and incident hypertension and incident diabetes.
Results: Overall 719 patients were diagnosed with OSA during the study periods; 614 were included as those at risk of developing either hypertension (N=265) or T2DM (N=489). Overall, 261 had severe OSA at diagnosis. Those with severe OSA were more likely to be middle aged, overweight, and have prevalent hypertension or T2DM. Among those without prevalent hypertension at OSA diagnosis, 47.4% (126/266) were subsequently diagnosed with hypertension. Among those without prevalent T2DM at OSA diagnosis, 16.3% (80/491) were subsequently diagnosed with T2DM. After adjusting for BMI and prevalent T2DM, the hazard rate of incident hypertension among patients with severe OSA was 1.35 (95%CI: 0.88-2.06) compared to the rate among patients with mild OSA. The hazard rate of incident T2DM among patients with severe OSA was 1.49 (95%CI: 0.83-2.67) compared to the rate among patients with mild OSA after adjusting for BMI and prevalent hypertension.
Discussion: We found high incidence rates of hypertension and T2DM among adults diagnosed with OSA. Severe OSA at diagnosis was associated with increased risk of either incident hypertension or T2DM, but not significantly (for p≤0.05).
Advisors/Committee Members: Dr. Roblin Magee, Dr. Matthew Magee.
Subjects/Keywords: Obstructive sleep apnea; hypertension; type 2 diabetes
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APA (6th Edition):
McArthur, D. (2016). Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/469
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McArthur, Dedria. “Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients.” 2016. Thesis, Georgia State University. Accessed November 15, 2019.
https://scholarworks.gsu.edu/iph_theses/469.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McArthur, Dedria. “Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients.” 2016. Web. 15 Nov 2019.
Vancouver:
McArthur D. Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients. [Internet] [Thesis]. Georgia State University; 2016. [cited 2019 Nov 15].
Available from: https://scholarworks.gsu.edu/iph_theses/469.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McArthur D. Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients. [Thesis]. Georgia State University; 2016. Available from: https://scholarworks.gsu.edu/iph_theses/469
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hong Kong
22.
李晶洁; Li, Jingjie.
Norepinephrine increases the level of monoamine oxidase-A
and plays a role in intermittent hypoxia induced injury in SH-SY5Y
cells.
Degree: M. Phil., 2016, University of Hong Kong
URL: Li,
J.
[李晶洁].
(2016).
Norepinephrine
increases
the
level
of
monoamine
oxidase-A
and
plays
a
role
in
intermittent
hypoxia
induced
injury
in
SH-SY5Y
cells.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5816262.
;
http://dx.doi.org/10.5353/th_b5816262
;
http://hdl.handle.net/10722/237866
► Obstructive sleep apnea (OSA) is a common breathing sleep disorder prevalent all over the world. Norepinephrine (NE) levels were reportedly to be elevated in the…
(more)
▼ Obstructive sleep apnea (OSA) is a common breathing
sleep disorder prevalent all over the world. Norepinephrine (NE)
levels were reportedly to be elevated in the circulatory system of
OSA patients. Monoamine oxidase A (MAO-A) is important for the NE
deamination and produces H2O2 as a catalytic byproduct. I
hypothesized that elevated NE levels mediate upregulated MAO-A
expression induced by intermittent hypoxia, resulting in the
cellular injury. In SH-SY5Y cells, constitutively expressing only
MAO-A not MAO-B, intermittent hypoxia induced cell death in a dose
and time dependent manner, which was antagonized by MAO-A inhibitor
M30 or clorgyline.
In addition, clorgyline mitigated the elevated
levels of inflammatory cytokines (tumor necrosis factor-α and
interleukin-1β) and apoptotic markers (Bcl-2 and cleaved caspase-3)
induced by intermittent hypoxia. Moreover, a significant increase
in the level of expression of enzymes for the NE biosynthesis,
namely dopamine -hydroxylase (DBH) and phosphorylated tyrosine
hydroxylase (TH) was observed, which was partially prevented by
antioxidant N-acetyl cysteine or calcium channel blocker
nifedipine. Furthermore, exogenous NE administration, significantly
increased the expression of MAO-A in the cells with or without
concurrent treatment of intermittent hypoxia, which was blocked by
NE transporter inhibitor desipramine. Blockade of MAO-A with
clorgyline significantly attenuated the upregulated MAO-A
expression and the deteriorated levels of oxidative stress (GSSH to
GSH ratio, superoxide dismutase and catalase) induced by NE. In
summary, my results suggest that the upregulation of MAO-A
expression driven by elevated NE levels could be a maladaptive
response to intermittent hypoxia leading to oxidative stress,
inflammation and apoptosis. These results may provide a possible
pathophysiological pathway of OSA-comorbid neurological disease and
MAO-A could be a potential target to alleviate the impact of
intermittent hypoxia.
published_or_final_version
Biomedical Sciences
Master
Master of Philosophy
Subjects/Keywords: Noradrenaline; Sleep apnea syndromes; Monoamine oxidase
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Manager
APA (6th Edition):
李晶洁; Li, J. (2016). Norepinephrine increases the level of monoamine oxidase-A
and plays a role in intermittent hypoxia induced injury in SH-SY5Y
cells. (Masters Thesis). University of Hong Kong. Retrieved from Li, J. [李晶洁]. (2016). Norepinephrine increases the level of monoamine oxidase-A and plays a role in intermittent hypoxia induced injury in SH-SY5Y cells. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5816262. ; http://dx.doi.org/10.5353/th_b5816262 ; http://hdl.handle.net/10722/237866
Chicago Manual of Style (16th Edition):
李晶洁; Li, Jingjie. “Norepinephrine increases the level of monoamine oxidase-A
and plays a role in intermittent hypoxia induced injury in SH-SY5Y
cells.” 2016. Masters Thesis, University of Hong Kong. Accessed November 15, 2019.
Li, J. [李晶洁]. (2016). Norepinephrine increases the level of monoamine oxidase-A and plays a role in intermittent hypoxia induced injury in SH-SY5Y cells. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5816262. ; http://dx.doi.org/10.5353/th_b5816262 ; http://hdl.handle.net/10722/237866.
MLA Handbook (7th Edition):
李晶洁; Li, Jingjie. “Norepinephrine increases the level of monoamine oxidase-A
and plays a role in intermittent hypoxia induced injury in SH-SY5Y
cells.” 2016. Web. 15 Nov 2019.
Vancouver:
李晶洁; Li J. Norepinephrine increases the level of monoamine oxidase-A
and plays a role in intermittent hypoxia induced injury in SH-SY5Y
cells. [Internet] [Masters thesis]. University of Hong Kong; 2016. [cited 2019 Nov 15].
Available from: Li, J. [李晶洁]. (2016). Norepinephrine increases the level of monoamine oxidase-A and plays a role in intermittent hypoxia induced injury in SH-SY5Y cells. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5816262. ; http://dx.doi.org/10.5353/th_b5816262 ; http://hdl.handle.net/10722/237866.
Council of Science Editors:
李晶洁; Li J. Norepinephrine increases the level of monoamine oxidase-A
and plays a role in intermittent hypoxia induced injury in SH-SY5Y
cells. [Masters Thesis]. University of Hong Kong; 2016. Available from: Li, J. [李晶洁]. (2016). Norepinephrine increases the level of monoamine oxidase-A and plays a role in intermittent hypoxia induced injury in SH-SY5Y cells. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5816262. ; http://dx.doi.org/10.5353/th_b5816262 ; http://hdl.handle.net/10722/237866
Central Connecticut State University
23.
Gagnon, Victoria Lee.
Obstructive Sleep Apnea Syndrome and Associated Health Risks.
Degree: Department of Biology, 2008, Central Connecticut State University
URL: http://content.library.ccsu.edu/u?/ccsutheses,1031
► Sleep apnea syndrome is a disease that has become increasing more prevalent in the United States in the past fifty years. Because of the newness…
(more)
▼ Sleep apnea syndrome is a disease that has become increasing more prevalent in the United States in the past fifty years. Because of the newness of this disease it can often be misdiagnosed or even completely missed in individuals.
Sleep apnea syndrome poses many complications to individuals that have it, but as this review will show with the proper treatment and/or weight loss most of the complications will diminish or be completely resolved. Because of this it is important to know the signs, symptoms and what predisposes patients to
sleep apnea so it can be properly diagnosed and patients can receive treatment. Individuals with
sleep apnea are at risk for several complications. Glucose metabolism disorders and cardiac complications are the main complications that patients face. Along with these complications patients may also experience increased sleepiness and depression which can affect patients in how they are able to function in their daily lives. This thesis is a literature review which attempts to bring together many aspects of
sleep apnea into a comprehensive review. This thesis will discuss the types of
sleep apnea and general background, what can predispose an individual to and the risks of
sleep apnea, the complications that
sleep apnea can cause, and what options are available to treat and control
sleep apnea, in hopes of making people more aware of the disease and the treatment options that are available.
Advisors/Committee Members: Rollin, Ruth;.
Subjects/Keywords: Sleep apnea syndromes
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APA (6th Edition):
Gagnon, V. L. (2008). Obstructive Sleep Apnea Syndrome and Associated Health Risks. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,1031
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gagnon, Victoria Lee. “Obstructive Sleep Apnea Syndrome and Associated Health Risks.” 2008. Thesis, Central Connecticut State University. Accessed November 15, 2019.
http://content.library.ccsu.edu/u?/ccsutheses,1031.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gagnon, Victoria Lee. “Obstructive Sleep Apnea Syndrome and Associated Health Risks.” 2008. Web. 15 Nov 2019.
Vancouver:
Gagnon VL. Obstructive Sleep Apnea Syndrome and Associated Health Risks. [Internet] [Thesis]. Central Connecticut State University; 2008. [cited 2019 Nov 15].
Available from: http://content.library.ccsu.edu/u?/ccsutheses,1031.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gagnon VL. Obstructive Sleep Apnea Syndrome and Associated Health Risks. [Thesis]. Central Connecticut State University; 2008. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1031
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universidade Nova
24.
Pinto, Paula Maria Gonçalves .
Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?.
Degree: 2009, Universidade Nova
URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522
► RESUMO: A síndrome de apneia hipopneia obstrutiva do sono (SAHOS), pela sua prevalência e consequências clínicas, nomeadamente as de natureza cardiovascular, é actualmente considerada um…
(more)
▼ RESUMO: A síndrome de apneia hipopneia obstrutiva do sono (SAHOS), pela sua prevalência e consequências clínicas, nomeadamente as de natureza cardiovascular, é actualmente considerada um problema de saúde pública.
A patogénese da doença cardiovascular na SAHOS não está ainda completamente
estabelecida, mas parece ser multifactorial, envolvendo diversos mecanismos que
incluem a hiperactividade do sistema nervoso simpático, a disfunção endotelial, a
activação selectiva de vias inflamatórias, o stress oxidativo vascular e a disfunção
metabólica.
A terapêutica com CPAP diminui grandemente o risco de eventos cardiovasculares
fatais e não fatais. O CPAP está inequivocamente indicado para o tratamento da
SAHOS grave, no entanto, não é consensual a sua utilização nos doentes com SAHOS
ligeira/moderada sem hipersonolência diurna associada. Tendo em conta este facto, é
fundamental que as indicações terapêuticas do CPAP nestes doentes tenham uma
relação custo-eficácia favorável. Assim, dado o posicionamento do estado da arte
relativamente ao estudo da disfunção endotelial e da activação do sistema nervoso
simpático estar centrada maioritariamente nos doentes com SAHOS grave,
desenvolvemos este estudo com o objectivo de comparar os níveis plasmáticos de
nitratos, os níveis de catecolaminas urinárias e os valores de pressão arterial nos doentes com SAHOS ligeira/moderada e grave e avaliar a resposta destes parâmetros ao tratamento com CPAP durante um mês.
Realizámos um estudo prospectivo, incidindo sobre uma população de 67 doentes do
sexo masculino com o diagnóstico de SAHOS (36 com SAHOS ligeira/moderada e
31com SAHOS grave). O protocolo consistia em 3 visitas: antes da terapêutica com
CPAP (visita 1), uma semana após CPAP (visita 2) e um mês após CPAP (visita 3). Nas visitas 1 e 3, eram submetidos a três colheitas de sangue às 11 pm, 4 am e 7 am para
doseamento dos nitratos plasmáticos e na visita 2 apenas às 7 am. Nas visitas 1 e 3 era
também efectuada uma colheita de urina de 24 horas para o doseamento das
catecolaminas urinárias e eram submetidos a uma monitorização ambulatória da pressão
arterial de 24 horas (MAPA). Foi ainda estudado um grupo controlo de 30 indivíduos do
sexo masculino não fumadores sem patologia conhecida e sem evidência de SAHOS.
Antes da terapêutica com CPAP, verificou-se uma diminuição significativa dos níveis
de nitratos ao longo da noite quer nos doentes com SAHOS ligeira/moderada, quer nos
doentes com SAHOS grave. No entanto, esta redução diferia nos 2 grupos de doentes,
sendo significativamente superior nos doentes com SAHOS grave (27,6±20,1% vs
16,5±18,5%; p<0,05). Após um mês de tratamento com CPAP, verificou-se um
aumento significativo dos valores de nitratos plasmáticos apenas nos doentes com
SAHOS grave, mantendo-se os níveis de nitratos elevados ao longo da noite, já não
existindo o decréscimo desses valores ao longo da mesma.
Os valores de noradrenalina basais eram significativamente superiores nos doentes com
SAHOS grave comparativamente com os doentes com SAHOS ligeira/moderada…
Advisors/Committee Members: Gomes, Maria João Marques, Caetano, Maria Cristina de Brito Eusébio Bárbara Prista.
Subjects/Keywords: Sleep Apnea Syndromes; Nitric Oxide; Pneumologia
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APA (6th Edition):
Pinto, P. M. G. (2009). Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pinto, Paula Maria Gonçalves . “Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?.” 2009. Thesis, Universidade Nova. Accessed November 15, 2019.
http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pinto, Paula Maria Gonçalves . “Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?.” 2009. Web. 15 Nov 2019.
Vancouver:
Pinto PMG. Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?. [Internet] [Thesis]. Universidade Nova; 2009. [cited 2019 Nov 15].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pinto PMG. Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?. [Thesis]. Universidade Nova; 2009. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cincinnati
25.
De Icaza Murua, Alberto.
Obstructive Sleep Apnea and the Challenges of Positive
Airway Pressure Therapy: Designing for Chronic Disease
Management.
Degree: MDES, Design, Architecture, Art and Planning:
Design, 2018, University of Cincinnati
URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522165131011304
► A team of engineers at the University of Cincinnati College of Medicine are developing a new technology for Positive Airway Pressure Therapy in the treatment…
(more)
▼ A team of engineers at the University of Cincinnati
College of Medicine are developing a new technology for Positive
Airway Pressure Therapy in the treatment of Obstructive
Sleep
Apnea. This technology and the latent user needs that have not been
met by current solutions in the market, create an opportunity for
design. This work is divided intro three phases: Understanding,
Making and Consolidating. Literature review provided background
information on the prevalence and morbidity of the disease, the
challenges of therapy and the lack of adherence. During the
understanding phase more than 50 in depth face-to-face interviews
were conducted, which provided a broad comprehension of the user
experience with treatment and the PAP device, the commercial
environment and the stakeholders involved. A set of criteria was
defined from the learnings and applied during the making phase into
were ideation, prototyping and user testing of headgear concepts
with users. The consolidation phase comprehends the discussion and
conclusions of the thesis. The insights from the second phase were
summarized into a list of recommendations for future design
research. In conclusion, the problem of adherence is highly
complex, which makes it necessary to consider all stakeholders for
a solution to be successful. The role of the designer in medical
design can make the difference in getting a well-engineered product
to produce good clinical outcomes, because the emotional dimension
of therapy is critical in the management of chronic
disease.
Advisors/Committee Members: Doehler, Steven (Committee Chair).
Subjects/Keywords: Design; Obstructive; Sleep; Apnea; Compliance; Emotional; Design
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APA (6th Edition):
De Icaza Murua, A. (2018). Obstructive Sleep Apnea and the Challenges of Positive
Airway Pressure Therapy: Designing for Chronic Disease
Management. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522165131011304
Chicago Manual of Style (16th Edition):
De Icaza Murua, Alberto. “Obstructive Sleep Apnea and the Challenges of Positive
Airway Pressure Therapy: Designing for Chronic Disease
Management.” 2018. Masters Thesis, University of Cincinnati. Accessed November 15, 2019.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522165131011304.
MLA Handbook (7th Edition):
De Icaza Murua, Alberto. “Obstructive Sleep Apnea and the Challenges of Positive
Airway Pressure Therapy: Designing for Chronic Disease
Management.” 2018. Web. 15 Nov 2019.
Vancouver:
De Icaza Murua A. Obstructive Sleep Apnea and the Challenges of Positive
Airway Pressure Therapy: Designing for Chronic Disease
Management. [Internet] [Masters thesis]. University of Cincinnati; 2018. [cited 2019 Nov 15].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522165131011304.
Council of Science Editors:
De Icaza Murua A. Obstructive Sleep Apnea and the Challenges of Positive
Airway Pressure Therapy: Designing for Chronic Disease
Management. [Masters Thesis]. University of Cincinnati; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522165131011304
University of Toronto
26.
Horton, Garret A.
Activation of a Medullary Respiratory Motor Circuit by Remote Control.
Degree: 2016, University of Toronto
URL: http://hdl.handle.net/1807/74880
► Obstructive sleep apnea (OSA) can be triggered by reduced tongue muscle tone during sleep. The hypoglossal motor nucleus (HMN) is the source of motor output…
(more)
▼ Obstructive sleep apnea (OSA) can be triggered by reduced tongue muscle tone during sleep. The hypoglossal motor nucleus (HMN) is the source of motor output to the tongue, and is a logical pharmacological target for treatment. Targets in this region exist; drugs able to specifically modulate them do not. To test the feasibility of this approach, we modelled a drug-receptor interaction at the HMN by selectively activating engineered receptors inserted into the HMN. Receptor activation by a systemically administered drug increased tongue muscle activity during sleep. Importantly, tongue muscle activity was increased during both rapid eye movement (REM) and non-REM sleep to near-waking levels. The results of this thesis show that selective activation of a pharmacological target locally expressed at the HMN results in sustained tongue muscle activity throughout sleep. This establishes proof-of-principle for modulating a restricted target at the HMN as a viable strategy for pharmacologically treating OSA.
M.Sc.
Advisors/Committee Members: Horner, Richard L, Physiology.
Subjects/Keywords: Apnea; Chemogenetics; DREADD; Hypoglossal; Obstructive; Sleep; 0719
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Manager
APA (6th Edition):
Horton, G. A. (2016). Activation of a Medullary Respiratory Motor Circuit by Remote Control. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74880
Chicago Manual of Style (16th Edition):
Horton, Garret A. “Activation of a Medullary Respiratory Motor Circuit by Remote Control.” 2016. Masters Thesis, University of Toronto. Accessed November 15, 2019.
http://hdl.handle.net/1807/74880.
MLA Handbook (7th Edition):
Horton, Garret A. “Activation of a Medullary Respiratory Motor Circuit by Remote Control.” 2016. Web. 15 Nov 2019.
Vancouver:
Horton GA. Activation of a Medullary Respiratory Motor Circuit by Remote Control. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/1807/74880.
Council of Science Editors:
Horton GA. Activation of a Medullary Respiratory Motor Circuit by Remote Control. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/74880
University of Minnesota
27.
Kwon, Younghoon.
Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis.
Degree: MS, Clinical Research, 2014, University of Minnesota
URL: http://hdl.handle.net/11299/165557
► Background: Obstructive sleep apnea (OSA) is a common condition believed to be linked to cardiovascular comorbidities. Its potential effect on progression of subclinical atherosclerosis is…
(more)
▼ Background: Obstructive sleep apnea (OSA) is a common condition believed to be linked to cardiovascular comorbidities. Its potential effect on progression of subclinical atherosclerosis is not well studied. We tested the hypothesis that OSA is associated with progression of coronary artery calcium (CAC) score. We also evaluated whether traditional cardiovascular risk factors mediated the association. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective epidemiologic cohort which has had a total of 5 clinic visits. Our primary analytic sample included 2,603 participants who at or near visit 2 (2002-2004) completed a sleep questionnaire and underwent coronary computerized tomography (CT), and underwent a repeat coronary CT approximately 8 years later (Visit 5: 2010-2011). Participants were categorized by their self-reported sleep breathing history: OSA: n= 102; Habitual snore: n = 666; Normal: n= 1835. mean age: 61.2).Results: Absolute CAC scores varied at visit 2, with the highest CAC prevalence among those with OSA, and lower but similar CAC prevalences among those who were habitual snorers or normal. Over 8 years of follow-up, greater progression of CAC was observed among those with OSA vs. those classified as normal (mean increase of 227.7 vs.135.6 Agatston units). This difference persisted after adjustment for BMI but was not significant after adjustment for cardiovascular risk factors (138.2 vs. 185.9 Agatston units; p = 0.08). CAC progression among habitual snorers was similar to that observed in the normal group.Conclusion: Self-reported sleep apnea was associated with CAC score progression after adjustment for demographics, behaviors and BMI. However, the association was not significant after accounting for cardiovascular risk factors which may mediate the association between OSA and CAC.
Subjects/Keywords: Coronary artery calcium; Sleep apnea; Snoring
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APA (6th Edition):
Kwon, Y. (2014). Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/165557
Chicago Manual of Style (16th Edition):
Kwon, Younghoon. “Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis.” 2014. Masters Thesis, University of Minnesota. Accessed November 15, 2019.
http://hdl.handle.net/11299/165557.
MLA Handbook (7th Edition):
Kwon, Younghoon. “Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis.” 2014. Web. 15 Nov 2019.
Vancouver:
Kwon Y. Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis. [Internet] [Masters thesis]. University of Minnesota; 2014. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/11299/165557.
Council of Science Editors:
Kwon Y. Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis. [Masters Thesis]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/165557
University of New Mexico
28.
Alcock, John.
The effect of sympathetic activation on gut microbiota in obstructive sleep apnea.
Degree: Biomedical Sciences Graduate Program, 2013, University of New Mexico
URL: https://digitalrepository.unm.edu/biom_etds/75
► Background: Patients with obstructive sleep apnea (OSA) suffer from increased mortality because of complications from metabolic and cardiovascular disease. Excess sympathetic nervous activity and catecholamine…
(more)
▼ Background: Patients with obstructive
sleep apnea (OSA) suffer from increased mortality because of complications from metabolic and cardiovascular disease. Excess sympathetic nervous activity and catecholamine exposure contribute to the disease associations of OSA, but the underlying mechanism remains enigmatic. Because catecholamines cause overgrowth of bacteria in the class Enterobacteriaceae in the laboratory, this translational study proposed a role for altered gut microbiota in the complications of OSA. Objectives: We tested the hypothesis that catecholamine excess in disordered
sleep alters intestinal microbiota by comparing urinary catecholamines and the fecal microbiome of 24 patients with obstructive
sleep apnea and 23 controls. Results: Next-generation sequencing of the gut microbiome using the Illumina platform provided evidence for a trend toward altered community structure of gut microbiota in patients with
sleep apnea. A positive linear relationship was seen in norepinephrine exposure and Enterobacteriaceae in patients with
sleep apnea, but no such relationship occurred in controls. Conclusions: These findings provide preliminary support for a central role of gut microbiota in the complications of
sleep.
Advisors/Committee Members: Lin, Henry, Shuttleworth, William, Villareal, Dennis, Lin, Henry.
Subjects/Keywords: Microbiota; Obstructive Sleep Apnea; Catecholamines; Inflammation; Metabolism
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APA (6th Edition):
Alcock, J. (2013). The effect of sympathetic activation on gut microbiota in obstructive sleep apnea. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/75
Chicago Manual of Style (16th Edition):
Alcock, John. “The effect of sympathetic activation on gut microbiota in obstructive sleep apnea.” 2013. Masters Thesis, University of New Mexico. Accessed November 15, 2019.
https://digitalrepository.unm.edu/biom_etds/75.
MLA Handbook (7th Edition):
Alcock, John. “The effect of sympathetic activation on gut microbiota in obstructive sleep apnea.” 2013. Web. 15 Nov 2019.
Vancouver:
Alcock J. The effect of sympathetic activation on gut microbiota in obstructive sleep apnea. [Internet] [Masters thesis]. University of New Mexico; 2013. [cited 2019 Nov 15].
Available from: https://digitalrepository.unm.edu/biom_etds/75.
Council of Science Editors:
Alcock J. The effect of sympathetic activation on gut microbiota in obstructive sleep apnea. [Masters Thesis]. University of New Mexico; 2013. Available from: https://digitalrepository.unm.edu/biom_etds/75
University of California – San Francisco
29.
Asghari, Sara.
A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population.
Degree: Oral and Craniofacial Sciences, 2013, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/4j93r18c
► IntroductionObstructive sleep apnea (OSA) is characterized by breathing disturbances during sleep, and daytime sleepiness.1 Prevalence of OSA has been cited as 3-33% for men and…
(more)
▼ IntroductionObstructive sleep apnea (OSA) is characterized by breathing disturbances during sleep, and daytime sleepiness.1 Prevalence of OSA has been cited as 3-33% for men and 2-9% for women.2-4 Risk factors for OSA include obesity, male gender, age, neck circumference, high blood pressure, and specific craniofacial anomalies.1,2,5,6 Craniofacial findings in OSA patients include an inferiorly-positioned hyoid relative to the mandibular plane, a relatively shorter maxilla and mandible, larger overjet, an increased mandibular plane angle, and an increased ANB angle.7-10 Our hypothesis is that in an adult orthodontic patient population, specific skeletal cephalometric measurements can distinguish between OSA high-risk and low-risk patients, and that there is a preventive effect of orthognathic surgery in young adulthood for developing OSA later in life. Materials and MethodsWe conducted a cross-sectional study evaluating OSA risk in adult orthodontic and orthognathic surgery patients from the UCSF Orthodontic and Oral and Maxillofacial Surgery clinics. We used a questionnaire composed of the Berlin Questionnaire (BQ), and the Epworth Sleepiness Scale (ESS) to assess the risk of OSA. Each orthodontic subject's lateral cephalogram was digitized. Logistic regression was used to evaluate the association between the subjects' specific cephalometric measurements, and the results of the BQ and ESS. Results27 orthodontic subjects and 28 surgical subjects were included. In the orthodontic group, none of the female subjects and 4 of the male subjects scored `high-risk' on the BQ. Male gender (p < 0.05) was found to be significantly associated with being classified as `high-risk' by the BQ in the orthodontic patient group. No difference was found in the BQ and ESS results of the orthodontic and surgical groups. The mandibular plane to hyoid distance (MPH) was found to be moderately associated with being classified as `high-risk' by the BQ (p < 0.1). Conclusions1. Our questionnaire serves as an excellent screening tool for orthodontic patients. 2. Prevalence of probable OSA was found to be 40% for males and in 0% of the females in this study's orthodontic patient population.3. There is a positive association between likelihood of OSA and the following factors: male gender, and an inferiorly-positioned hyoid.
Subjects/Keywords: Dentistry; Adult; Apnea; Obstructive; Orthodontic; Patient; Sleep
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APA (6th Edition):
Asghari, S. (2013). A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/4j93r18c
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Asghari, Sara. “A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population.” 2013. Thesis, University of California – San Francisco. Accessed November 15, 2019.
http://www.escholarship.org/uc/item/4j93r18c.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Asghari, Sara. “A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population.” 2013. Web. 15 Nov 2019.
Vancouver:
Asghari S. A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population. [Internet] [Thesis]. University of California – San Francisco; 2013. [cited 2019 Nov 15].
Available from: http://www.escholarship.org/uc/item/4j93r18c.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Asghari S. A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population. [Thesis]. University of California – San Francisco; 2013. Available from: http://www.escholarship.org/uc/item/4j93r18c
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Arizona
30.
ARBALLO, JESUS MARVIN.
Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/628040
► Background: Sleep apnea is a common health disorder that is strongly associated with many serious comorbidities. At Patel Medical Clinic located in rural southwestern Arizona,…
(more)
▼ Background:
Sleep apnea is a common health disorder that is strongly associated with many serious comorbidities. At Patel Medical Clinic located in rural southwestern Arizona, the clinic director acknowledged the need to identify individuals that may have this condition but may go undetected. Presentation of symptoms in women can be misleading for diagnosis and conceals the need for further workup. Although men are more commonly recognized for having this condition, women of 50 years of age and older are vulnerable as the risk for
sleep apnea increases significantly after menopause. In this study, women 50 years of age and older were asked to volunteer to determine
sleep apnea risk and to identify barriers to diagnosis.
Methods
The purpose of this quality improvement project was to evaluate the use of a validated screening tool in identifying women 50 years of age and older in a rural southwestern internal medicine practice who are at moderate to high-risk of
sleep apnea using a cross-sectional quantitative survey design. The study took place at Patel Medical Clinic, a private medical establishment located in rural Arizona. All clinic patients who are female and 50 years of age and older and patients of this clinic during data collection times were able to participate in the study, regardless of
sleep apnea status.
Results
Most participants were of the 60-69 and 70-79 age groups. Study subjects consisted of 54 women. Of these, (37) 68.5% of participants scored at moderate or high-risk of
sleep apnea. A total of (27) 50% participants scored as “moderate-risk,” (10) 18.5% scored as high-risk. Of the 54 participants, (13) 24% had a previous diagnosis of
sleep apnea. Of those 13 with an established diagnosis, (7) 53% scored in the moderate-risk category, and (5) 38 % scored in the high-risk category. Out of those that were referred for
sleep study but unable to participate, various barriers were identified that were unique to each individual participant.
Discussion/Recommendations
Symptoms of
sleep apnea are vastly present among participants. Many participants that scored as having moderate to high-risk have not been referred for
sleep study. A screening tool could potentially reduce the number of moderate-to-high-risk patients from going unrecognized. Additional long-term studies are necessary to further examine barriers for diagnostic testing and how to better ensure that these tests are completed. Women with
sleep apnea often present with gender-specific symptoms and could greatly benefit from a female-focused questionnaire.
Advisors/Committee Members: Pacheco, Christy (advisor), Brown, Angela (committeemember), Daly, Patricia (committeemember).
Subjects/Keywords: post menopause;
rural;
screening;
sleep apnea;
Women
Record Details
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APA ·
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APA (6th Edition):
ARBALLO, J. M. (2018). Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/628040
Chicago Manual of Style (16th Edition):
ARBALLO, JESUS MARVIN. “Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
.” 2018. Doctoral Dissertation, University of Arizona. Accessed November 15, 2019.
http://hdl.handle.net/10150/628040.
MLA Handbook (7th Edition):
ARBALLO, JESUS MARVIN. “Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
.” 2018. Web. 15 Nov 2019.
Vancouver:
ARBALLO JM. Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
. [Internet] [Doctoral dissertation]. University of Arizona; 2018. [cited 2019 Nov 15].
Available from: http://hdl.handle.net/10150/628040.
Council of Science Editors:
ARBALLO JM. Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
. [Doctoral Dissertation]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/628040
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Open Access Theses and Dissertations