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Boston University
1.
Lee, Deborah.
The interrelationship between central sleep apnea and atrial fibrillation.
Degree: MS, Medical Sciences, 2020, Boston University
URL: http://hdl.handle.net/2144/41285 
► INTRODUCTION: Research has consistently shown that sleep apnea is strongly associated with atrial fibrillation, with several lines of evidence demonstrating that this relationship is bidirectional…
(more)
▼ INTRODUCTION: Research has consistently shown that
sleep apnea is strongly associated with atrial fibrillation, with several lines of evidence demonstrating that this relationship is bidirectional and that each condition predisposes to and/or exacerbates the other. Many studies have suggested potential pathophysiologic mechanisms underlying this relationship, and that
sleep apnea and atrial fibrillation share many of the same cardiovascular risk factors further implies that multiple pathways are likely involved in the mechanistic link between the two. Although the
sleep apnea-atrial fibrillation relationship is quite established, numerous aspects of this association still require further study, such as the role of gender and the potential impact of positive airway pressure therapy. A deeper understanding of how these individual factors may be involved in the interrelationship between
sleep apnea and atrial fibrillation has important clinical implications, such as for risk stratification and screening of patients. Thus, this study aims to further understand the different aspects and modulating factors of the
sleep apnea-atrial fibrillation link, focusing on central
sleep apnea as less is known about the central
sleep apnea-atrial fibrillation relationship.
METHODS: A total of 153 patients, originally seen at the cardiac electrophysiology clinic at Beth Israel Deaconess Medical Center and subsequently offered home
sleep apnea testing, were included in this study. Several databases – home
sleep apnea testing results, polysomnography reports, electrocardiogram reports and patient management systems – were used to obtain a variety of data on
sleep pathology, high loop gain status, left ventricular ejection fraction and positive airway pressure therapy efficacy and compliance. Patients were considered to have central
sleep apnea if home testing results demonstrated a central
apnea-hypopnea index of 5 or greater and/or if the patient was documented as having high loop gain on polysomnography. Data were analyzed using the Statistical Package for Social Sciences software in order to examine how factors such as gender and therapy use may affect the
sleep apnea-atrial fibrillation relationship, in a patient population with
sleep pathology of at least moderate severity.
RESULTS: Statistical analysis revealed significant
sleep disturbances in the central
sleep apnea patients compared to the non-central
sleep apnea patients. Gender was found to be significantly associated with central
sleep apnea, but not obstructive
sleep apnea. When postmenopausal (age≥51) women were analyzed, very few patients met the study criteria for central
sleep apnea, yet the majority were documented as having atrial fibrillation. As expected, positive airway pressure therapy was found to be beneficial for all users, but the common pattern of declining compliance to therapy was seen as adherence decreased over the course of three months. Of the select central
sleep apnea patients who had sufficient data available, comparison of positive airway pressure…
Advisors/Committee Members: Thomas, Robert J. (advisor), Auerbach, Sanford H. (advisor).
Subjects/Keywords: Medicine; Atrial fibrillation; Central sleep apnea; Sleep apnea; Sleep-disordered breathing
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APA (6th Edition):
Lee, D. (2020). The interrelationship between central sleep apnea and atrial fibrillation. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41285
Chicago Manual of Style (16th Edition):
Lee, Deborah. “The interrelationship between central sleep apnea and atrial fibrillation.” 2020. Masters Thesis, Boston University. Accessed March 04, 2021.
http://hdl.handle.net/2144/41285.
MLA Handbook (7th Edition):
Lee, Deborah. “The interrelationship between central sleep apnea and atrial fibrillation.” 2020. Web. 04 Mar 2021.
Vancouver:
Lee D. The interrelationship between central sleep apnea and atrial fibrillation. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/2144/41285.
Council of Science Editors:
Lee D. The interrelationship between central sleep apnea and atrial fibrillation. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41285
University of Arizona
2.
Lane, Sandra.
Screening for Obstructive Sleep Apnea in the Primary Care Setting
.
Degree: 2020, University of Arizona
URL: http://hdl.handle.net/10150/650762
► Purpose: The purpose was to find out if screening for obstructive sleep apnea in the primary care setting using a questionnaire increases referrals for further…
(more)
▼ Purpose: The purpose was to find out if screening for obstructive
sleep apnea in the primary care setting using a questionnaire increases referrals for further
sleep studies. The goal was to increase the number of referrals for follow-up
sleep studies. Background:
Sleep apnea is a
sleep and respiratory disorder that causes frequent wakings in the night due to the throat muscles collapsing and causing the person to wake up to get needed oxygen. This disorder affects more than 22 million Americans and has a 2.47 increased morbidity and mortality risk if left untreated. Studies show that as many as 1 in 5 individuals struggle with
sleep disordered breathing and 80% of these disorders go undiagnosed. Untreated
sleep apnea has been linked to cardiovascular disease, hypertension, diabetes, strokes, and depression. There is currently no routine screening for
sleep apnea in the primary care setting, but literature shows screening with the STOP-BANG Questionnaire increases follow-up for
sleep studies and earlier treatment. The STOP-BANG Questionnaire has better sensitivity and specificity compared to other tools tested.
Methods: The STOP-BANG Questionnaire was implemented to screen overweight patients with hypertension within one primary care practice for one month and referrals for follow-up were compared to the one month prior. A positive screen was a score of 4 or higher on the questionnaire. The post-intervention total was compared to the pre-intervention total and success was shown if the number of referrals increased by more than 10%.
Results: Prior to the intervention, the clinic referred and set up four patients for follow-up
sleep studies. Post intervention, the clinic referred and set up eight patients for follow-up
sleep studies. There was a 100% increase in referrals in the post intervention group. Out of 12 participants, 2 screened negative, 10 screened positive, 2 refused referral while 8 accepted the referral for follow-up.
Conclusion: The use of the STOP-BANG Questionnaire within the primary care setting increases referral for follow-up
sleep studies. The use of this screening tool should be incorporated and continued within this primary care and all primary care practice settings should implement screening with the STOP-BANG Questionnaire.
Advisors/Committee Members: Gregg, Renee (advisor), Newton, Tarnia (committeemember), Pacheco, Christy (committeemember).
Subjects/Keywords: Obstructive sleep apnea;
obstructive sleep apnea;
Primary Care;
screening tool;
Sleep apnea;
STOPBANG Questionnaire
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APA (6th Edition):
Lane, S. (2020). Screening for Obstructive Sleep Apnea in the Primary Care Setting
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/650762
Chicago Manual of Style (16th Edition):
Lane, Sandra. “Screening for Obstructive Sleep Apnea in the Primary Care Setting
.” 2020. Doctoral Dissertation, University of Arizona. Accessed March 04, 2021.
http://hdl.handle.net/10150/650762.
MLA Handbook (7th Edition):
Lane, Sandra. “Screening for Obstructive Sleep Apnea in the Primary Care Setting
.” 2020. Web. 04 Mar 2021.
Vancouver:
Lane S. Screening for Obstructive Sleep Apnea in the Primary Care Setting
. [Internet] [Doctoral dissertation]. University of Arizona; 2020. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10150/650762.
Council of Science Editors:
Lane S. Screening for Obstructive Sleep Apnea in the Primary Care Setting
. [Doctoral Dissertation]. University of Arizona; 2020. Available from: http://hdl.handle.net/10150/650762
University of Alberta
3.
Nazarali, Natasha.
Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms.
Degree: MS, Medical Sciences-Orthodontics, 2016, University of Alberta
URL: https://era.library.ualberta.ca/files/cgq67jr39s
► Objective: To determine the predictive ability of the Alberta Pediatric Obstructive Sleep Apnea (APOSA) Index for orthodontic treatment need in pediatric patients with obstructive sleep…
(more)
▼ Objective: To determine the predictive ability of the
Alberta Pediatric Obstructive Sleep Apnea (APOSA) Index for
orthodontic treatment need in pediatric patients with obstructive
sleep apnea symptoms. Methods: Thirty orthodontic records,
representing a spectrum of craniofacial and oral features and
severity, were evaluated for orthodontic treatment need using the
APOSA index. The results were compared to treatment decisions made
by ten expert orthodontists. Results: Receiver operating
characteristic (ROC) curve demonstrated a cutoff score of 6.5 with
a sensitivity of 94.1% and specificity of 99%. Conclusions: The
APOSA index is a useful and predictive tool to determine
orthodontic treatment need in pediatric patients with OSA symptoms.
A sum score of 6.5 or greater on the APOSA index suggests that the
patient may benefit from referral to an orthodontist. Our findings
indicate that the APOSA index is a useful and predictive tool for
orthodontic treatment need in pediatric patients with OSA
symptoms.
Subjects/Keywords: orthodontics; obstructive sleep apnea; index
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APA ·
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Manager
APA (6th Edition):
Nazarali, N. (2016). Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cgq67jr39s
Chicago Manual of Style (16th Edition):
Nazarali, Natasha. “Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms.” 2016. Masters Thesis, University of Alberta. Accessed March 04, 2021.
https://era.library.ualberta.ca/files/cgq67jr39s.
MLA Handbook (7th Edition):
Nazarali, Natasha. “Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms.” 2016. Web. 04 Mar 2021.
Vancouver:
Nazarali N. Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms. [Internet] [Masters thesis]. University of Alberta; 2016. [cited 2021 Mar 04].
Available from: https://era.library.ualberta.ca/files/cgq67jr39s.
Council of Science Editors:
Nazarali N. Validation of the Alberta Pediatric Obstructive Sleep Apnea
(APOSA) Index for Orthodontic Treatment Need in Pediatric Patients
with Obstructive Sleep Apnea Symptoms. [Masters Thesis]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/cgq67jr39s
Queens University
4.
Pang, Helen Wai Kiu.
Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
.
Degree: Physiology, 2011, Queens University
URL: http://hdl.handle.net/1974/6625
► Background: Obstructive sleep apnea (OSA) has been associated with atrial enlargement in response to high arterial and pulmonary pressures and increased sympathetic tone. Continuous positive…
(more)
▼ Background: Obstructive sleep apnea (OSA) has been associated with atrial enlargement in response to high arterial and pulmonary pressures and increased sympathetic tone. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; its impact on atrial electrical remodeling has not been investigated however. Signal-averaged p-wave (SAPW) is a non-invasive quantitative method to determine p-wave duration, an accepted marker for atrial electrical remodeling. The objective was to determine whether CPAP induces reverse atrial electrical remodeling in patients with severe OSA.
Methods: Prospective study in consecutive patients attending the Sleep Clinic at Kingston General Hospital. All patients underwent full polysomnography. OSA-negative and severe OSA were defined as apnea-hypopnea index (AHI) < 5 events/hour and AHI ≥ 30 events/hour, respectively. In severe OSA patients, SAPW was determined pre- and post-intervention with CPAP for 4 - 6 weeks. In OSA-negative controls, SAPW was recorded at baseline and 4 - 6 weeks thereafter without any intervention.
Results: A total of 19 severe OSA patients and 10 controls were included in the analysis. Mean AHI and minimum O2 saturation were 41.4 ± 10.1 events/hour and 80.5 ± 6.5% in severe OSA patients and 2.8 ± 1.2 events/hour and 91.4 ± 2.1% in controls. Baseline BMI was different between severe OSA patients and controls (34.3 ± 5.4 vs 26.6 ± 4.6 kg/m2; p < 0.001). At baseline, severe OSA patients had a greater SAPW duration than controls (131.9 ± 10.4 vs 122.8 ± 10.5 ms; p = 0.02). After CPAP intervention, there was a significant reduction of SAPW duration in severe OSA (131.9 ± 10.4 to 126.2 ± 8.8 ms; p < 0.001). In controls, SAPW duration did not change within 4 - 6 weeks.
Conclusion: CPAP induced reverse atrial electrical remodeling in patients with severe OSA as represented by a significant reduction in SAPW duration.
Subjects/Keywords: Atrial Remodeling
;
Obstructive Sleep Apnea
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APA (6th Edition):
Pang, H. W. K. (2011). Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6625
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pang, Helen Wai Kiu. “Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
.” 2011. Thesis, Queens University. Accessed March 04, 2021.
http://hdl.handle.net/1974/6625.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pang, Helen Wai Kiu. “Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
.” 2011. Web. 04 Mar 2021.
Vancouver:
Pang HWK. Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
. [Internet] [Thesis]. Queens University; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1974/6625.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pang HWK. Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
. [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6625
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Harvard University
5.
Shin, Christina.
The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications.
Degree: Doctor of Medicine, 2016, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215
► Purpose: Postoperative respiratory complications (PRCs) are associated with significant morbidity, mortality, and costs. Obstructive sleep apnea (OSA), which is often undiagnosed in the surgical population,…
(more)
▼ Purpose: Postoperative respiratory complications (PRCs) are associated with significant morbidity, mortality, and costs. Obstructive sleep apnea (OSA), which is often undiagnosed in the surgical population, may be a contributing factor.
Methods: We conducted an observational study of adult surgical patients at Partners HealthCare hospitals (2007-2014) using electronic patient and perioperative data. OSA was defined as the occurrence of an OSA diagnostic code preceded by a polysomnography procedure code. A priori defined variables were analyzed by multivariable logistic regression analysis to develop our score. Score validity was assessed by investigating the score’s ability to predict noninvasive ventilation. Following the development of our Score for Preoperative Prediction of Obstructive Sleep Apnea (SPOSA), we assessed the effect of high OSA risk on our primary outcome, PRCs within seven postoperative days. In order to improve the clinical utility of the score, a dichotomized OSA risk scale was developed using the SPOSA cut point of 7. Propensity score matched cohorts were used to understand patient and health care outcomes among patients identified as high risk for OSA.
Results: Predictors for OSA included BMI >25 kg/m2 and comorbidities, including hypertension, diabetes, and dyslipidemia. The score yielded an area under the curve of 0.81. Inclusion of early postoperative desaturation did not improve the score. Noninvasive ventilation was significantly associated with high OSA risk (odds ratio 1.45, 95% confidence interval 1.20-1.76, p<0.001), confirming the validity of the SPOSA. Using a dichotomized endpoint, 29,087 patients were identified as high risk for OSA and 7.7% of these patients experienced PRCs. OSA risk was significantly associated with PRCs (OR 1.38, 95% CI 1.1.26-1.51, p<0.001). High OSA risk was also significantly associated with increased postoperative length of stay, increased total costs of care, and higher rates of admission to the intensive care unit, adverse discharge, and readmission within 30 days of initial discharge.
Conclusions: The SPOSA assesses OSA risk and predicts the occurrence of respiratory complications. High OSA risk is associated with adverse clinical and care outcomes. Utilization of the SPOSA will allow providers to risk stratify patients prior to admission and may help reduce perioperative consequences of OSA.
Scholarly Project
Subjects/Keywords: Obstructive sleep apnea; respiratory complications
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APA ·
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Manager
APA (6th Edition):
Shin, C. (2016). The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215
Chicago Manual of Style (16th Edition):
Shin, Christina. “The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications.” 2016. Doctoral Dissertation, Harvard University. Accessed March 04, 2021.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215.
MLA Handbook (7th Edition):
Shin, Christina. “The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications.” 2016. Web. 04 Mar 2021.
Vancouver:
Shin C. The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications. [Internet] [Doctoral dissertation]. Harvard University; 2016. [cited 2021 Mar 04].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215.
Council of Science Editors:
Shin C. The Effect of Obstructive Sleep Apnea on Postoperative Respiratory Complications. [Doctoral Dissertation]. Harvard University; 2016. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620215
University of Illinois – Chicago
6.
Stache, Rutger Wolfgang.
Oral Appliance and Pharmacological Agents in the Treatment of Sleep Apnea: A Pilot Clinical Study.
Degree: 2019, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/23864
► Hypothesis: Augmentation of a mandibular advancement oral appliance (OA) by pharmacotherapy (ondansetron+fluoxetine) will increase therapeutic efficacy in moderate to severe obstructive sleep apnea (OSA) patients.…
(more)
▼ Hypothesis: Augmentation of a mandibular advancement oral appliance (OA) by pharmacotherapy (ondansetron+fluoxetine) will increase
therapeutic efficacy in moderate to severe obstructive
sleep apnea
(OSA) patients.
Methods: Fifteen subjects met inclusion criteria and were enrolled.
Subjects with moderate-severe OSA were treated with a TAP3 Elite® OA
plus placebo medication for two weeks, followed by a combination
regimen of ondansetron (24 mg/day) and fluoxetine (10 mg/day) with
continued use of the OA for four weeks.
Results: Seven subjects (5 male and 2 female, BMI 39.1±6.6) completed
the study. AHI OA + Medications (22.1±16.3) was lower than the AHI
baseline (31.7±11.2).
Sleep efficiency and oxygen desaturation indices
improved. Subjective (ESS) and objective (PVT) daytime sleepiness
showed improvement. Mean total airway volume at end inspiration
increased by 35% with OA compared to without OA. Minimum cross
sectional area (CSA) increased by 48.8% with OA compared to without
OA
Conclusions: Combination of pharmacotherapy and oral appliance maybe a viable option in treating patients with moderate to severe OSA.
Advisors/Committee Members: Galang-Boquiren, Maria Therese S (advisor), Viana, Grace (committee member), Prasad, Bharati (committee member), Galang-Boquiren, Maria Therese S (chair).
Subjects/Keywords: OSA; Orthodontics; Obstructive sleep apnea
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Manager
APA (6th Edition):
Stache, R. W. (2019). Oral Appliance and Pharmacological Agents in the Treatment of Sleep Apnea: A Pilot Clinical Study. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23864
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stache, Rutger Wolfgang. “Oral Appliance and Pharmacological Agents in the Treatment of Sleep Apnea: A Pilot Clinical Study.” 2019. Thesis, University of Illinois – Chicago. Accessed March 04, 2021.
http://hdl.handle.net/10027/23864.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stache, Rutger Wolfgang. “Oral Appliance and Pharmacological Agents in the Treatment of Sleep Apnea: A Pilot Clinical Study.” 2019. Web. 04 Mar 2021.
Vancouver:
Stache RW. Oral Appliance and Pharmacological Agents in the Treatment of Sleep Apnea: A Pilot Clinical Study. [Internet] [Thesis]. University of Illinois – Chicago; 2019. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10027/23864.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stache RW. Oral Appliance and Pharmacological Agents in the Treatment of Sleep Apnea: A Pilot Clinical Study. [Thesis]. University of Illinois – Chicago; 2019. Available from: http://hdl.handle.net/10027/23864
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Technology, Sydney
7.
Maali, Y.
An automatic sleep apnea analysis with soft computing approaches.
Degree: 2014, University of Technology, Sydney
URL: http://hdl.handle.net/10453/30399
► Sleep Apnea (SA) is a common disorder without “age-specific” that affects approximately 2% of women and 4% of men; sleep apnea is characterized by repetitive…
(more)
▼ Sleep Apnea (SA) is a common disorder without “age-specific” that affects approximately 2% of women and 4% of men; sleep apnea is characterized by repetitive cessation of breathing during sleep. The consequences of the sleep apnea include daytime sleepiness, impaired cognitive function, impaired memory, neurocognitive dysfunction, and development of cardiovascular disorders, metabolic dysfunction, and impaired quality of life. This thesis investigates the automated detection and prediction of sleep apnea. Many researchers have concentrated on automated detection of sleep apnea, but not much comprehensive or well-ordered work has been done on signal and feature selection or on predicting of the sleep apnea.
The objective is to find the best set of signals as input and the best set of features from selected signals that can be used by a machine learning approaches to study sleep apnea. The best set here is not only refers to a smallest set of signals with a good performance in sleep apnea analysis but also consideration for a set of signals that can be easily acquired from patients.
During the course of this thesis, several algorithms were developed. These algorithms can be used in sleep apnea studies or in wider machine learning areas. The most important contributions of this thesis can be summarized as below:
-Developing a new signal segmentation algorithm designed specifically for sleep apnea by attention to its properties. This algorithm chose times windows with a greater probability of containing at least one sleep apnea event. After that these segmentations are generated, they should be reviewed by the machine learning approaches to be classified as sleep apnea or normal.
-Developing a novel Support Vector Machine (SVM)-based approach named Self-Advising Support Vector Machine (SA-SVM) that transfers more knowledge from the training phase of SVM to the test phase. This idea helps SVM to learn from misclassified data in training phase and use this gained knowledge, in the testing phase. This approach can be used in any binary classification problems and it shows also high impact in sleep apnea detection.
-Developing a new parallel structure for Particle Swarm Optimisation (PSO). Finding the best set of input signals or the best set of features required a huge amount of computation power which a single PSO – or other optimisation approaches- cannot deal with, so a new hierarchical multi-master structure for parallel PSO was developed in this thesis, which quickly revealed its advantages over previous parallel PSO structures.
In this thesis real data has been used from Concord Repatriation General Hospital in Sydney. Obtained result shows a good performance in detection and classification of sleep apnea. Together with detection and classification, a prediction of sleep apnea was also considered. The prediction stage examines some famous neural networks structures and demonstrated how to improve the final result by taking advantage of multi neural network approach.
Subjects/Keywords: Sleep Apnea.; Soft Computing.
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APA ·
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Manager
APA (6th Edition):
Maali, Y. (2014). An automatic sleep apnea analysis with soft computing approaches. (Thesis). University of Technology, Sydney. Retrieved from http://hdl.handle.net/10453/30399
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Maali, Y. “An automatic sleep apnea analysis with soft computing approaches.” 2014. Thesis, University of Technology, Sydney. Accessed March 04, 2021.
http://hdl.handle.net/10453/30399.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Maali, Y. “An automatic sleep apnea analysis with soft computing approaches.” 2014. Web. 04 Mar 2021.
Vancouver:
Maali Y. An automatic sleep apnea analysis with soft computing approaches. [Internet] [Thesis]. University of Technology, Sydney; 2014. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10453/30399.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Maali Y. An automatic sleep apnea analysis with soft computing approaches. [Thesis]. University of Technology, Sydney; 2014. Available from: http://hdl.handle.net/10453/30399
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Florida
8.
Mundt, Jennifer M.
An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders.
Degree: PhD, Psychology - Clinical and Health Psychology, 2017, University of Florida
URL: https://ufdc.ufl.edu/UFE0050826
► Short sleep duration and insomnia have been linked to higher pain and an increased risk of developing chronic pain, but relatively little research has examined…
(more)
▼ Short
sleep duration and insomnia have been linked to higher pain and an increased risk of developing chronic pain, but relatively little research has examined the contribution of
sleep disordered breathing (SDB) to pain. This study examined the unique contributions of SDB and insomnia to chronic pain. Patients who presented to the University of Florida Health
Sleep Center for overnight polysomnography were invited to participate, provided they had no history of using positive airway pressure. Participants (N = 105) completed additional questionnaires about their
sleep (Insomnia Severity Index) and pain (Medical College of Virginia Pain Questionnaire, pain locations, chronic pain diagnoses) before undergoing overnight polysomnography. They subsequently completed an online
sleep/pain diary for two weeks. Physicians diagnosed 52.38% with obstructive
sleep apnea (OSA) and 4.76% with insomnia, though 20.95% were classified as having chronic insomnia based on
sleep diaries used for the study. In a hierarchical regression, polysomnography-measured total
sleep time, but not measures of
sleep fragmentation (
apnea-hypopnea index, spontaneous arousals) or hypoxemia (SaO2 nadir), was related to pain. The majority of participants
Advisors/Committee Members: ROBINSON,MIKE E (committee chair), DOTSON,VONETTA M (committee member), EBNER,NATALIE CHRISTINA (committee member).
Subjects/Keywords: apnea – insomnia – pain – polysomnography – sleep
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Manager
APA (6th Edition):
Mundt, J. M. (2017). An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0050826
Chicago Manual of Style (16th Edition):
Mundt, Jennifer M. “An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders.” 2017. Doctoral Dissertation, University of Florida. Accessed March 04, 2021.
https://ufdc.ufl.edu/UFE0050826.
MLA Handbook (7th Edition):
Mundt, Jennifer M. “An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders.” 2017. Web. 04 Mar 2021.
Vancouver:
Mundt JM. An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders. [Internet] [Doctoral dissertation]. University of Florida; 2017. [cited 2021 Mar 04].
Available from: https://ufdc.ufl.edu/UFE0050826.
Council of Science Editors:
Mundt JM. An Examination of Pain's Relationship to Sleep Fragmentation and Disordered Breathing across Common Sleep Disorders. [Doctoral Dissertation]. University of Florida; 2017. Available from: https://ufdc.ufl.edu/UFE0050826
University of Arizona
9.
Sweeney, Nathan.
Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/628049
► Primary liver cancer is the seventh most common cancer worldwide and the second highest cause of cancer mortality. The incidence of hepatocellular carcinoma (HCC) has…
(more)
▼ Primary liver cancer is the seventh most common cancer worldwide and the second highest cause of cancer mortality. The incidence of hepatocellular carcinoma (HCC) has increased 80% in the past two decades and now comprises 85% of all primary liver cancer. Obesity increases the risk of developing HCC two-fold in women and five-fold in men. Co-morbidities common to obesity including non-alcoholic steatohepatitis (NASH), hepatic inflammation, and lipid accumulation increase the risk of developing HCC. Obstructive
sleep apnea (OSA), a state of chronic intermittent hypoxia which is common in obese individuals, also increases the incidence of NASH. With a U.S. population that is approximately 33% obese, having OSA at 30-50%, we estimate the co-incidence of obesity and OSA is 10-16.5% of the entire U.S. population. Diet-induced obesity or intermittent hypoxia induces hepatic lipid accumulation and diet-induced obesity was recently shown to promote HCC tumor development. Whether obesity, chronic intermittent hypoxia, and their combination hasten hepatic lipid accumulation and HCC tumor progression remains unclear. In our studies, we monitored tumor development utilizing micro-computed tomography imaging and discovered that tumors developed fastest in mice that consumed a high fat diet. Upon further investigation, these mice also tended to have higher serum levels of AST and ALT and gained more weight than their counterparts. However, the addition of hypoxia lead to a decrease in weight gained, as well as a reduction in hepatic lipid accumulation and tumor formation. Extraction of mRNA from mouse livers revealed an up-regulation HIF-1α in mice fed a high fat diet without treatment with hypoxia that correlated strongly with tumorigenesis. Remarkably, hypoxia was found in mice treated with hypoxia as well as the mice that were fed a high fat diet only. These findings suggest that hepatic lipid accumulation produces endogenous hepatic hypoxia which associates with increased hepatic HIF-1α expression that correlates with tumorigenesis. Collectively, these data reveal a mechanism that potentially explains progression from early liver disease to HCC.
Advisors/Committee Members: Martinez, Jesse (advisor), Breihl, Margaret (committeemember), Cherrington, Nathan (committeemember), Doetschman, Tom (committeemember), Tax, Frans (committeemember).
Subjects/Keywords: Liver Cancer;
Obesity;
Sleep Apnea
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APA (6th Edition):
Sweeney, N. (2018). Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/628049
Chicago Manual of Style (16th Edition):
Sweeney, Nathan. “Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
.” 2018. Doctoral Dissertation, University of Arizona. Accessed March 04, 2021.
http://hdl.handle.net/10150/628049.
MLA Handbook (7th Edition):
Sweeney, Nathan. “Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
.” 2018. Web. 04 Mar 2021.
Vancouver:
Sweeney N. Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
. [Internet] [Doctoral dissertation]. University of Arizona; 2018. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10150/628049.
Council of Science Editors:
Sweeney N. Investigating the Role of Obesity and Obstructive Sleep Apnea in Hepatocellular Carcinoma Progression
. [Doctoral Dissertation]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/628049
University of Sydney
10.
Rowsell, Luke Joshua.
The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
.
Degree: 2016, University of Sydney
URL: http://hdl.handle.net/2123/16441
► This thesis aims to evaluate the effect of 40mg oral slow release morphine on obstructive sleep apnea (OSA) and awake ventilatory chemoreflexes in 60 OSA…
(more)
▼ This thesis aims to evaluate the effect of 40mg oral slow release morphine on obstructive sleep apnea (OSA) and awake ventilatory chemoreflexes in 60 OSA men in a randomised, double-blind placebo controlled crossover study. The study attempts to phenotype and genotype the potentially large variability of OSA response to a common dose of morphine using cutting edge techniques. We found that morphine caused mild respiratory depression but did not affect the percent of TST spent below 90% oxygen saturation (T90), nor apnea-hypopnea index (AHI). However, large inter-individual variability was observed. Morphine tended to improve T90 in A/G vs A/A OPRM1 genotype subjects. 2. Morphine reduced slow wave sleep and rapid eye movement (REM) sleep overall, however did not attenuate REM sleep in subjects with (CT + TT) vs CC HTR3B genotype. Total sleep time (TST) increased following morphine in C/C vs (C/T + T/T) ABCB1 genotype subjects only. 3. CO2 ventilatory recruitment threshold (VRT) was increased and hypercapnic/hypoxic ventilatory response (HCVR/HVR) was depressed overall. HCVR depression following morphine was greater in A/G vs A/A OPRM1 subjects, and C/C vs (C/T + T/T) ABCB1 subjects. 4. A mechanism by which morphine may improve OSA in some OSA patients through reducing chemosensitivity and widening CO2 reserve was proposed. 5. Negative linear relationships were found in severe OSA patients between baseline VRT and morphine effect on AHI, oxygen desaturation index, arousal index and T90. 6. Subjects with extreme improvement in T90 following morphine were older, had higher VRT and were often A/G OPRM1 genotype compared to those with greatest deterioration. In conclusion, 40mg morphine on average only caused mild respiratory depression but with a large variability in men with OSA. The large inter-individual variability may be partly explained by baseline awake chemoreflexes. Certain genotypes associated with differential morphine effect on OSA were identified.
Subjects/Keywords: obstructive sleep apnea;
opoids;
morphine
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Manager
APA (6th Edition):
Rowsell, L. J. (2016). The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/16441
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rowsell, Luke Joshua. “The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
.” 2016. Thesis, University of Sydney. Accessed March 04, 2021.
http://hdl.handle.net/2123/16441.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rowsell, Luke Joshua. “The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
.” 2016. Web. 04 Mar 2021.
Vancouver:
Rowsell LJ. The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
. [Internet] [Thesis]. University of Sydney; 2016. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/2123/16441.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rowsell LJ. The Effect of Acute Oral Morphine on Obstructive Sleep Apnea
. [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/16441
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
The Ohio State University
11.
Maerz, Rachael Jean, Maerz.
Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study.
Degree: MS, Dentistry, 2018, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596
► Objectives: Sleep apnea is a common chronic condition, with prevalence estimated at approximately 26% and 13% of adult males and females, respectively. The consequence of…
(more)
▼ Objectives:
Sleep apnea is a common chronic condition,
with prevalence estimated at approximately 26% and 13% of adult
males and females, respectively. The consequence of untreated OSA
is increased morbidity and mortality. Long-term adherence to
treatment for chronic conditions in developed countries is
estimated at 50%. The aim of this study was to test whether a
multifactorial intervention in addition to the standard of care
increases adherence rates in patients using a titratable oral
appliance to treat OSA.Methods: Subjects are between the ages of
18-60+, and have a diagnosis of OSA. After informed consent, they
were assigned at random to the experimental or control group. A
power analysis indicated group size of 30 subjects each was
necessary to demonstrate a difference in the three variables
(p<0.05) of +/- 15% between groups with a power of 0.86. The
control group received routine care. Experimental subjects received
in addition: educational material at scheduled intervals,
spouse/partner packet, monthly follow up communication,
communication with primary physician and dentist about patients,
printouts of sensor data, and gift cards for timely follow up with
sleep physician. Comparison of adherence was at 1-, 3-, and 6 month
time points. Variables were: mean nights of appliance wear, mean
nights adherent to prescribed wear time, mean nights worn per week,
and the mean hours worn per night.Results: Forty subjects have been
enrolled to date, 15 females and 25 males. Seventeen have been
recorded at time point one (30 days). Seven subjects have left the
study and there have been 5 sensor malfunctions (patients
continuing to use appliance in the absence of objective
monitoring). There were no significant differences between group
for gender, age, and BMI at time point 1. There were no significant
differences between groups for total nights worn, total nights
adherent, number of nights/week, and hours/night for time points
1.Conclusions: The interventions were well received by the
subjects, and most of the repeated interventions could be carried
out by administrative personnel. There was a significant failure
rate with the sensors that added a level of frustration to the
process. There were no statistical differences for total nights
worn, total nights adherent, number of nights/week, or hrs/night.
This may be due to inadequate sample size. The means for all
variables were higher in the experimental group compared with the
control group.
Advisors/Committee Members: Firestone, Allen (Advisor).
Subjects/Keywords: Dentistry; adherence, sleep apnea
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APA ·
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MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Maerz, Rachael Jean, M. (2018). Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596
Chicago Manual of Style (16th Edition):
Maerz, Rachael Jean, Maerz. “Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study.” 2018. Masters Thesis, The Ohio State University. Accessed March 04, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596.
MLA Handbook (7th Edition):
Maerz, Rachael Jean, Maerz. “Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study.” 2018. Web. 04 Mar 2021.
Vancouver:
Maerz, Rachael Jean M. Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study. [Internet] [Masters thesis]. The Ohio State University; 2018. [cited 2021 Mar 04].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596.
Council of Science Editors:
Maerz, Rachael Jean M. Multi-factorial intervention to increase adherence to oral
appliance therapy for obstructive sleep apnea; A feasibility
study. [Masters Thesis]. The Ohio State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1522324879726596
Brno University of Technology
12.
Vrana, Vojtěch.
Detekce spánkové apnoe u dospělých pacientů: Detection of Sleep Apnea in Adults.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/173608
► The goal of this work is to construct a device detecting apneic respiration pauses during sleep. The most common cause of apnea pauses is obstruction…
(more)
▼ The goal of this work is to construct a device detecting apneic respiration pauses during
sleep. The most common cause of
apnea pauses is obstruction of the airways, eg, airway collapse.
Apnea leads to a deterioration in the quality of
sleep and increases the risk of cardiovascular disease. The controller is designed on the Arduino Uno development board. The whole measuring device consists of two circuits for measuring the external manifestations of movement of respiratory muscles and a microphone for measuring the presence of air flow.
Advisors/Committee Members: Sekora, Jiří (advisor), Králík, Martin (referee).
Subjects/Keywords: Kontrolér spánkové apnoe; spánková apnoe; spánek; Arduino; Sleep Apnea Controller; Sleep Apnea; Sleep; Arduino
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vrana, V. (2019). Detekce spánkové apnoe u dospělých pacientů: Detection of Sleep Apnea in Adults. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/173608
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vrana, Vojtěch. “Detekce spánkové apnoe u dospělých pacientů: Detection of Sleep Apnea in Adults.” 2019. Thesis, Brno University of Technology. Accessed March 04, 2021.
http://hdl.handle.net/11012/173608.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vrana, Vojtěch. “Detekce spánkové apnoe u dospělých pacientů: Detection of Sleep Apnea in Adults.” 2019. Web. 04 Mar 2021.
Vancouver:
Vrana V. Detekce spánkové apnoe u dospělých pacientů: Detection of Sleep Apnea in Adults. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/11012/173608.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vrana V. Detekce spánkové apnoe u dospělých pacientů: Detection of Sleep Apnea in Adults. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/173608
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Alberta
13.
Lau, Amanda A.
Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study.
Degree: MS, Department of Public Health Sciences, 2014, University of Alberta
URL: https://era.library.ualberta.ca/files/c5138jd94j
► Inadequate childhood sleep may adversely affect neurodevelopment, behaviour, and metabolic function. Few population-based studies have examined sleep duration and sleep disordered breathing (SDB) within the…
(more)
▼ Inadequate childhood sleep may adversely affect
neurodevelopment, behaviour, and metabolic function. Few
population-based studies have examined sleep duration and sleep
disordered breathing (SDB) within the first year of life. Families
in the Edmonton site of the Canadian Healthy Infant Longitudinal
Development (CHILD) birth cohort study completed sleep
questionnaires (Pediatric Sleep Questionnaires (PSQ) and Brief
Infant Sleep Questionnaire (BISQ)), and questionnaires related to
child health, environmental/household exposures, and parental
health, stress, and sleep when their child was 3, 6, 9, and 12
months of age. The association between self-soothing and sleep
duration (i.e. total amount of sleep during day and night as
reported on the BISQ) was analyzed longitudinally with multivariate
linear regression using generalized estimating equations (GEE)
methods with exchangeable correlation matrix and robust errors.
Infant sleep was also analyzed cross-sectionally when the child was
3, 6, 9, 12 months of age using multivariable linear regression.
The association between BMI Z-Scores and SDB (i.e. answering
positively to more than 1/3 of the PSQ questions or a PSQ score of
0.33 or greater) was analyzed with cox proportional hazard
modeling. The earliest PSQ score of 0.33 or greater was used to
define time to SDB. Follow-up started at birth and data was
censored at 12 months of age if the infant did not have SDB or at
the child’s age if and when loss to follow up occurred. In an
additional analysis, PSQ questions relating to rhinitis were
excluded and added in the multivariate model to investigate the
association between rhinitis and SDB. Of the 845 Edmonton CHILD
participants, 765 had sleep duration data. Sleep duration was
inversely associated with age. On average, infants slept 14.08
hours at 3 months, 13.66 hours at 6 months, 13.41 hours at 9
months, and 13.51 hours at 12 months of age. Non self-soothing was
consistently associated with shorter sleep duration in longitudinal
and cross-sectional analyses. A multivariate longitudinal analysis
stratified by birth order was performed. Self-soothing infants
(-0.31 hours; 95% Confidence Interval (95%CI) -0.51, -0.11;
p<0.001 for first-born; -0.57 hours; 95%CI -0.76, -0.37;
p<0.001 for subsequent-born), sleep times after 21:00 (-0.67
hours; 95%CI -0.86, -0.45; p<0.001 for first-born; -0.61
hours; 95%CI -0.81, -0.42; p<0.001 for subsequent-born), and
a parent who perceived their child’s sleep as a small problem
(-0.62 hours; 95%CI -0.84, -0.40; p<0.001 for first-born;
-0.86 hours; 95%CI -1.08, -0.65; p<0.001 for
subsequent-born) and very serious problem (-2.19 hours; 95%CI
-3.00, -1.38; p<0.001 for first-born; -1.91 hours; 95%CI
-2.52, -1.31; p<0.001 for subsequent-born) were
significantly associated with shorter sleep duration in first-born
and subsequent-born infants. A child’s age was significantly
associated with shorter sleep duration in subsequent-born infants
but not first-born infants. In subsequent-born infants, infants
that were fed only…
Subjects/Keywords: pediatric; sleep duration; birth cohort; sleep disordered breathing; sleep apnea
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lau, A. A. (2014). Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c5138jd94j
Chicago Manual of Style (16th Edition):
Lau, Amanda A. “Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study.” 2014. Masters Thesis, University of Alberta. Accessed March 04, 2021.
https://era.library.ualberta.ca/files/c5138jd94j.
MLA Handbook (7th Edition):
Lau, Amanda A. “Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study.” 2014. Web. 04 Mar 2021.
Vancouver:
Lau AA. Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2021 Mar 04].
Available from: https://era.library.ualberta.ca/files/c5138jd94j.
Council of Science Editors:
Lau AA. Sleep and sleep disordered breathing in the first year of
life: a Canadian birth cohort study. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/c5138jd94j
Penn State University
14.
Lewis, Jordan Gaines.
Inflammation in Obstructive Sleep Apnea: Its Mediating Role and Potential as a Marker of Severity.
Degree: 2016, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/1v53jw96n
► Obstructive sleep apnea (OSA) is a prevalent disorder characterized by upper airway obstruction during sleep. This airway obstruction creates irregular breathing pauses, resulting in intermittent…
(more)
▼ Obstructive
sleep apnea (OSA) is a prevalent disorder characterized by upper airway obstruction during
sleep. This airway obstruction creates irregular breathing pauses, resulting in intermittent hypoxia and fragmented
sleep. Obesity – in particular, visceral (central) obesity – is the strongest risk factor for developing OSA. Primarily driven by inflammatory mechanisms, prolonged visceral obesity is also associated with development of the metabolic syndrome, a cluster of symptoms that increases the risk for cardiovascular disease and type 2 diabetes. Independent of obesity, however, OSA has also been linked to elevations in the proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα), and the acute phase reactant C-reactive protein (CRP) due to stresses induced by intermittent hypoxia. In the interminable quest to identify novel modifiable risk factors for cardiovascular disease and type 2 diabetes, the notion that OSA causes the metabolic syndrome is attractive; however, given the significant overlap in phenotypes, subclinical biomarkers, and health outcomes in obese non-apneics and patients with OSA, the model cannot be so simple. No study to date has attempted to disentangle the relative contribution of obesity-associated inflammation toward the development of OSA, nor how these biomarkers may reflect the cardiometabolic or neurocognitive severity of the disorder.
This dissertation explores these questions in a representative population sample of 421 adolescents, the Penn State Child Cohort, who were followed up in the
sleep laboratory eight years after their initial study visit. Examining OSA in adolescents presents a unique advantage; given that the majority of childhood OSA cases do not persist into adolescence, this age group captures a unique perspective into the early pathophysiology of the disorder. Specifically, based on consistent evidence demonstrating that adipose tissue is a major source of systemic inflammation, we explored five overarching hypotheses. In Chapter 3, we demonstrate how, similar to adults, OSA in adolescents is associated with elevated visceral fat area, particularly in boys. In Chapter 4, we show that inflammation is associated with obesity in adolescents, and is also elevated in those with OSA independent of obesity. In Chapter 5, we illustrate how a significant portion of the relationship between visceral obesity and OSA is mediated by systemic inflammation. Chapter 6 demonstrates how, using longitudinal data from the childhood baseline study, inflammation during childhood predicts
apnea and blood pressure reactivity in adolescence. Finally, in Chapter 7, we explore the potential of inflammation (namely, CRP) to serve as a marker of the cardiometabolic and neurocognitive severity of OSA in adolescents.
Taken together, these findings do not support a simple linear model of OSA pathophysiology, but rather a more complex vicious cycle in which visceral fat – through primarily inflammatory mechanisms – results in OSA; in turn, OSA is not an endpoint, but…
Advisors/Committee Members: Alexandros N Vgontzas, Dissertation Advisor/Co-Advisor.
Subjects/Keywords: obstructive sleep apnea; sleep-disordered breathing; sleep; adolescence; inflammation; obesity
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Manager
APA (6th Edition):
Lewis, J. G. (2016). Inflammation in Obstructive Sleep Apnea: Its Mediating Role and Potential as a Marker of Severity. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/1v53jw96n
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lewis, Jordan Gaines. “Inflammation in Obstructive Sleep Apnea: Its Mediating Role and Potential as a Marker of Severity.” 2016. Thesis, Penn State University. Accessed March 04, 2021.
https://submit-etda.libraries.psu.edu/catalog/1v53jw96n.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lewis, Jordan Gaines. “Inflammation in Obstructive Sleep Apnea: Its Mediating Role and Potential as a Marker of Severity.” 2016. Web. 04 Mar 2021.
Vancouver:
Lewis JG. Inflammation in Obstructive Sleep Apnea: Its Mediating Role and Potential as a Marker of Severity. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Mar 04].
Available from: https://submit-etda.libraries.psu.edu/catalog/1v53jw96n.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lewis JG. Inflammation in Obstructive Sleep Apnea: Its Mediating Role and Potential as a Marker of Severity. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/1v53jw96n
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Harvard University
15.
Tabari, Shaima.
The Longitudinal Effects of Orthodontic Therapy on the Obstructive Apnea Hypopnea Index (AHI).
Degree: DMSc, 2019, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42080554
► Objectives: To evaluate the cross-sectional relationship between sleep apnea and dental model measurements, cephalometric measurements (skeletal, dental, airway) and sleep-disordered breathing (SDB) questionnaires, in a…
(more)
▼ Objectives: To evaluate the cross-sectional relationship between sleep apnea and dental model measurements, cephalometric measurements (skeletal, dental, airway) and sleep-disordered breathing (SDB) questionnaires, in a convenience sample of orthodontic patients starting therapy.
Materials and Methods: Fifty-four orthodontic patients (male 46%, mean age 25.29 +/- 12.32) scheduled to start orthodontic treatment were prospectively evaluated with sleep studies, lateral cephalograms, intraoral dental scans and SDB questionnaires before orthodontic treatment. The primary outcome of interest was the obstructive Apnea Hypopnea Index (AHI) and whether or not the obstructive AHI score exceeded sleep apnea threshold. Predictors included dental model measurements, cephalometric (skeletal, dental, airway) measurements and SDB questionnaires: Epworth Sleepiness Scale and Pediatric Sleep Questionnaire.
Results: Results indicate statistically significant negative relationships between obstructive AHI and maxillary arch length (p= 0.013), maxillary intercanine width (p=0.004), mandibular intercanine width (p=0.026), maxillary arch perimeter (p=0.010), SNB (angle between sella, nasion and supramentale) (p= 0.043), upper incisor inclination (p=0.010) and position (p=0.001) (U1-NAdeg and U1-NAmm). Obstructive AHI had statistically significant positive relationship with upper airway length (p=0.007) (UAL) and pediatric sleep questionnaire (p=0.017).
Conclusion: Higher obstructive AHI scores were seen in an unselected population of orthodontic patients with posteriorly positioned and retroclined upper incisors, retrognathic mandible, increased length of the upper airway, decreased maxillary arch length, constricted maxillary and mandibular inter canine widths, decreased arch perimeter and higher pediatric sleep questionnaire. Orthodontists have an important opportunity to screen their patients with compatible findings for OSA.
Orthodontics
Advisors/Committee Members: Padwa, Dr. Bonnie L. (committee member), Shaefer, Dr. Jeffry R. (committee member), Baron, Dr. Roland (committee member).
Subjects/Keywords: Obstructive Sleep Apnea; Orthodontics; Tooth movement; Sleep; Cephalometrics; Sleep questionnaire.
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Manager
APA (6th Edition):
Tabari, S. (2019). The Longitudinal Effects of Orthodontic Therapy on the Obstructive Apnea Hypopnea Index (AHI). (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42080554
Chicago Manual of Style (16th Edition):
Tabari, Shaima. “The Longitudinal Effects of Orthodontic Therapy on the Obstructive Apnea Hypopnea Index (AHI).” 2019. Doctoral Dissertation, Harvard University. Accessed March 04, 2021.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:42080554.
MLA Handbook (7th Edition):
Tabari, Shaima. “The Longitudinal Effects of Orthodontic Therapy on the Obstructive Apnea Hypopnea Index (AHI).” 2019. Web. 04 Mar 2021.
Vancouver:
Tabari S. The Longitudinal Effects of Orthodontic Therapy on the Obstructive Apnea Hypopnea Index (AHI). [Internet] [Doctoral dissertation]. Harvard University; 2019. [cited 2021 Mar 04].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42080554.
Council of Science Editors:
Tabari S. The Longitudinal Effects of Orthodontic Therapy on the Obstructive Apnea Hypopnea Index (AHI). [Doctoral Dissertation]. Harvard University; 2019. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42080554
NSYSU
16.
Wang, Jen-feng.
AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information.
Degree: PhD, Mechanical and Electro-Mechanical Engineering, 2009, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820
► The diagnosis of obstructive sleep apnea (OSA) syndrome is overnight PSG (mutli-channel system). But itâs hard to be popularized for the general population (about twenty…
(more)
▼ The diagnosis of obstructive
sleep apnea (OSA) syndrome is overnight PSG (mutli-channel system). But itâs hard to be popularized for the general population (about twenty channel signals). In recent decades, several researches were devoted to a replacement system with only one channel signal (oxyhemoglobin saturation). However, itâs hard to match PSG systemâs report without EEG wake information. Consequently, two channels (oxyhemoglobin saturation and EEG) were used of this study to enhance the AHI (estimation index for
sleep apnea) prediction performance. After surveying the most recent studies, this work proposes a new basleline removal technique for oxygen saturation signal (SpO2) by using median filter. It was proved this technique improves the diagnostic accuracy for OSA. Furthermore, it is also found that by removing the wake periods, diagnostic accuracy can be improved further.
By counting the number of times that the desaturation level has dropped more than 2% for at least 3 seconds, the correlation coefficient between AHI and proposed feature is 0.9218. In addition, by removing the wake period, this correlation increases to 0.9425. By using this feature to classify patients with AHI value larger than 5, the proposed approach achieves 93.78% accuracy, 95.94% sensitivity, 78.87% specificity f. Such results demonstrate the feasibility of using single SpO2 channel system for OSA diagnosis.
Advisors/Committee Members: Jau-Wei Perng (chair), Pei-Chung Chen (chair), Chen-Wen Yen (committee member), Wei-Huang Lin (chair), Yaw-Terng Su (chair).
Subjects/Keywords: Obstructive sleep apnea syndrome; Oxyhemoglobin saturation
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APA (6th Edition):
Wang, J. (2009). AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820
Chicago Manual of Style (16th Edition):
Wang, Jen-feng. “AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information.” 2009. Doctoral Dissertation, NSYSU. Accessed March 04, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820.
MLA Handbook (7th Edition):
Wang, Jen-feng. “AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information.” 2009. Web. 04 Mar 2021.
Vancouver:
Wang J. AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information. [Internet] [Doctoral dissertation]. NSYSU; 2009. [cited 2021 Mar 04].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820.
Council of Science Editors:
Wang J. AHI prediction improvement by oxyhemoglobin desaturation features with new baseline definition and EEG wake information. [Doctoral Dissertation]. NSYSU; 2009. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717109-161820
University of Alberta
17.
Altalibi, Mostafa.
Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists.
Degree: MS, Medical Sciences-Orthodontics, 2015, University of Alberta
URL: https://era.library.ualberta.ca/files/c02870v88m
► Purpose: To develop a physician screening index for the oral and facial assessment of the orthodontic treatment-need in pediatric patients with Obstructive Sleep Apnea (OSA)…
(more)
▼ Purpose: To develop a physician screening index for
the oral and facial assessment of the orthodontic treatment-need in
pediatric patients with Obstructive Sleep Apnea (OSA) that may
diminish the severity of their OSA symptoms. Methods: Based on the
available literature and WHO guidelines for index development, a
draft index was produced, and subjected to multiple iterative
revisions based on the feedback from: 1) the Index Development
Group; 2) the External Review Group; and 3) the Steering Committee.
Once the index was formalized, it was subjected to reliability
testing Results: Based on the feedback from the Index Development
Group, the External Review Group and the Steering Committee, an
index has been developed that is simple, easy to understand and
easy to use. The index also exhibits a fair to substantial
inter-rater reliability, and moderate to almost perfect intra-rater
reliability. The orthodontic residents scored better than the
medical residents in the reliability tests and took less time to
use the index. The average time to use the index on 15 cases was
17:14min. Conclusions: This is a much needed, simple, and easy to
use index that is reliable among orthodontic residents and among
medical residents.
Subjects/Keywords: Index; Physician; Obstructive Sleep Apnea; Orthodontics
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APA (6th Edition):
Altalibi, M. (2015). Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c02870v88m
Chicago Manual of Style (16th Edition):
Altalibi, Mostafa. “Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists.” 2015. Masters Thesis, University of Alberta. Accessed March 04, 2021.
https://era.library.ualberta.ca/files/c02870v88m.
MLA Handbook (7th Edition):
Altalibi, Mostafa. “Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists.” 2015. Web. 04 Mar 2021.
Vancouver:
Altalibi M. Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists. [Internet] [Masters thesis]. University of Alberta; 2015. [cited 2021 Mar 04].
Available from: https://era.library.ualberta.ca/files/c02870v88m.
Council of Science Editors:
Altalibi M. Developing an Index for the Orthodontic Treatment Need in
Pediatric Patients with Obstructive Sleep Apnea: A Communication
Tool between Physicians and Orthodontists. [Masters Thesis]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/c02870v88m
University of Alberta
18.
Collinson, Mary O.
Living with sleep Apnea at work, home and leisure: a
phenomenological study.
Degree: MEd, Department of Educational Psychology, 1995, University of Alberta
URL: https://era.library.ualberta.ca/files/2j62s689p
Subjects/Keywords: Sleep apnea syndromes.
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APA (6th Edition):
Collinson, M. O. (1995). Living with sleep Apnea at work, home and leisure: a
phenomenological study. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2j62s689p
Chicago Manual of Style (16th Edition):
Collinson, Mary O. “Living with sleep Apnea at work, home and leisure: a
phenomenological study.” 1995. Masters Thesis, University of Alberta. Accessed March 04, 2021.
https://era.library.ualberta.ca/files/2j62s689p.
MLA Handbook (7th Edition):
Collinson, Mary O. “Living with sleep Apnea at work, home and leisure: a
phenomenological study.” 1995. Web. 04 Mar 2021.
Vancouver:
Collinson MO. Living with sleep Apnea at work, home and leisure: a
phenomenological study. [Internet] [Masters thesis]. University of Alberta; 1995. [cited 2021 Mar 04].
Available from: https://era.library.ualberta.ca/files/2j62s689p.
Council of Science Editors:
Collinson MO. Living with sleep Apnea at work, home and leisure: a
phenomenological study. [Masters Thesis]. University of Alberta; 1995. Available from: https://era.library.ualberta.ca/files/2j62s689p
University of Toronto
19.
Horton, Garret A.
Activation of a Medullary Respiratory Motor Circuit by Remote Control.
Degree: 2016, University of Toronto
URL: http://hdl.handle.net/1807/74880
► Obstructive sleep apnea (OSA) can be triggered by reduced tongue muscle tone during sleep. The hypoglossal motor nucleus (HMN) is the source of motor output…
(more)
▼ Obstructive sleep apnea (OSA) can be triggered by reduced tongue muscle tone during sleep. The hypoglossal motor nucleus (HMN) is the source of motor output to the tongue, and is a logical pharmacological target for treatment. Targets in this region exist; drugs able to specifically modulate them do not. To test the feasibility of this approach, we modelled a drug-receptor interaction at the HMN by selectively activating engineered receptors inserted into the HMN. Receptor activation by a systemically administered drug increased tongue muscle activity during sleep. Importantly, tongue muscle activity was increased during both rapid eye movement (REM) and non-REM sleep to near-waking levels. The results of this thesis show that selective activation of a pharmacological target locally expressed at the HMN results in sustained tongue muscle activity throughout sleep. This establishes proof-of-principle for modulating a restricted target at the HMN as a viable strategy for pharmacologically treating OSA.
M.Sc.
Advisors/Committee Members: Horner, Richard L, Physiology.
Subjects/Keywords: Apnea; Chemogenetics; DREADD; Hypoglossal; Obstructive; Sleep; 0719
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APA (6th Edition):
Horton, G. A. (2016). Activation of a Medullary Respiratory Motor Circuit by Remote Control. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74880
Chicago Manual of Style (16th Edition):
Horton, Garret A. “Activation of a Medullary Respiratory Motor Circuit by Remote Control.” 2016. Masters Thesis, University of Toronto. Accessed March 04, 2021.
http://hdl.handle.net/1807/74880.
MLA Handbook (7th Edition):
Horton, Garret A. “Activation of a Medullary Respiratory Motor Circuit by Remote Control.” 2016. Web. 04 Mar 2021.
Vancouver:
Horton GA. Activation of a Medullary Respiratory Motor Circuit by Remote Control. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1807/74880.
Council of Science Editors:
Horton GA. Activation of a Medullary Respiratory Motor Circuit by Remote Control. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/74880
University of Toronto
20.
Gruenspan, Grant Mitchell.
Developing New Algorithms to Assess the Effectiveness of Mandibular Advancement Devices for the Treatment of Sleep Apnea.
Degree: 2019, University of Toronto
URL: http://hdl.handle.net/1807/101818
► Mandibular advancement is a treatment for obstructive sleep apnea (OSA). The issue with this treatment is that it's hard to predict responders. We performed a…
(more)
▼ Mandibular advancement is a treatment for obstructive sleep apnea (OSA). The issue with this treatment is that it's hard to predict responders. We performed a systematic review of previous literature and examined the effects of clinical, craniofacial, and pharyngeal airway features to predict responders to mandibular advancement. Some studies suggested that a retruded mandible and smaller width of the oropharynx were the main characteristics of responders to mandibular advancement. However, other studies found that these features didn't differ between responders and non-responders. The second objective of this study was to find additional features that assess the response to mandibular advancement. We investigated the effect of mandibular advancement on snoring sound and sleep features. We found that mandibular advancement decreased the snoring intensity and reduced the apnea duration in the supine position. These findings suggest that mandibular advancement could improve other measures of sleep quality including snoring intensity and apnea duration.
M.H.Sc.
2020-07-28 00:00:00
Advisors/Committee Members: Yadollahi, Azadeh, Biomedical Engineering.
Subjects/Keywords: Mandibular Advancement; Obstructive Sleep Apnea; 0541
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APA (6th Edition):
Gruenspan, G. M. (2019). Developing New Algorithms to Assess the Effectiveness of Mandibular Advancement Devices for the Treatment of Sleep Apnea. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/101818
Chicago Manual of Style (16th Edition):
Gruenspan, Grant Mitchell. “Developing New Algorithms to Assess the Effectiveness of Mandibular Advancement Devices for the Treatment of Sleep Apnea.” 2019. Masters Thesis, University of Toronto. Accessed March 04, 2021.
http://hdl.handle.net/1807/101818.
MLA Handbook (7th Edition):
Gruenspan, Grant Mitchell. “Developing New Algorithms to Assess the Effectiveness of Mandibular Advancement Devices for the Treatment of Sleep Apnea.” 2019. Web. 04 Mar 2021.
Vancouver:
Gruenspan GM. Developing New Algorithms to Assess the Effectiveness of Mandibular Advancement Devices for the Treatment of Sleep Apnea. [Internet] [Masters thesis]. University of Toronto; 2019. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1807/101818.
Council of Science Editors:
Gruenspan GM. Developing New Algorithms to Assess the Effectiveness of Mandibular Advancement Devices for the Treatment of Sleep Apnea. [Masters Thesis]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/101818
Universidade Nova
21.
Pinto, Paula Maria Gonçalves .
Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?.
Degree: 2009, Universidade Nova
URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522
► RESUMO: A síndrome de apneia hipopneia obstrutiva do sono (SAHOS), pela sua prevalência e consequências clínicas, nomeadamente as de natureza cardiovascular, é actualmente considerada um…
(more)
▼ RESUMO: A síndrome de apneia hipopneia obstrutiva do sono (SAHOS), pela sua prevalência e consequências clínicas, nomeadamente as de natureza cardiovascular, é actualmente considerada um problema de saúde pública.
A patogénese da doença cardiovascular na SAHOS não está ainda completamente
estabelecida, mas parece ser multifactorial, envolvendo diversos mecanismos que
incluem a hiperactividade do sistema nervoso simpático, a disfunção endotelial, a
activação selectiva de vias inflamatórias, o stress oxidativo vascular e a disfunção
metabólica.
A terapêutica com CPAP diminui grandemente o risco de eventos cardiovasculares
fatais e não fatais. O CPAP está inequivocamente indicado para o tratamento da
SAHOS grave, no entanto, não é consensual a sua utilização nos doentes com SAHOS
ligeira/moderada sem hipersonolência diurna associada. Tendo em conta este facto, é
fundamental que as indicações terapêuticas do CPAP nestes doentes tenham uma
relação custo-eficácia favorável. Assim, dado o posicionamento do estado da arte
relativamente ao estudo da disfunção endotelial e da activação do sistema nervoso
simpático estar centrada maioritariamente nos doentes com SAHOS grave,
desenvolvemos este estudo com o objectivo de comparar os níveis plasmáticos de
nitratos, os níveis de catecolaminas urinárias e os valores de pressão arterial nos doentes com SAHOS ligeira/moderada e grave e avaliar a resposta destes parâmetros ao tratamento com CPAP durante um mês.
Realizámos um estudo prospectivo, incidindo sobre uma população de 67 doentes do
sexo masculino com o diagnóstico de SAHOS (36 com SAHOS ligeira/moderada e
31com SAHOS grave). O protocolo consistia em 3 visitas: antes da terapêutica com
CPAP (visita 1), uma semana após CPAP (visita 2) e um mês após CPAP (visita 3). Nas visitas 1 e 3, eram submetidos a três colheitas de sangue às 11 pm, 4 am e 7 am para
doseamento dos nitratos plasmáticos e na visita 2 apenas às 7 am. Nas visitas 1 e 3 era
também efectuada uma colheita de urina de 24 horas para o doseamento das
catecolaminas urinárias e eram submetidos a uma monitorização ambulatória da pressão
arterial de 24 horas (MAPA). Foi ainda estudado um grupo controlo de 30 indivíduos do
sexo masculino não fumadores sem patologia conhecida e sem evidência de SAHOS.
Antes da terapêutica com CPAP, verificou-se uma diminuição significativa dos níveis
de nitratos ao longo da noite quer nos doentes com SAHOS ligeira/moderada, quer nos
doentes com SAHOS grave. No entanto, esta redução diferia nos 2 grupos de doentes,
sendo significativamente superior nos doentes com SAHOS grave (27,6±20,1% vs
16,5±18,5%; p<0,05). Após um mês de tratamento com CPAP, verificou-se um
aumento significativo dos valores de nitratos plasmáticos apenas nos doentes com
SAHOS grave, mantendo-se os níveis de nitratos elevados ao longo da noite, já não
existindo o decréscimo desses valores ao longo da mesma.
Os valores de noradrenalina basais eram significativamente superiores nos doentes com
SAHOS grave comparativamente com os doentes com SAHOS ligeira/moderada…
Advisors/Committee Members: Gomes, Maria João Marques, Caetano, Maria Cristina de Brito Eusébio Bárbara Prista.
Subjects/Keywords: Sleep Apnea Syndromes; Nitric Oxide; Pneumologia
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APA (6th Edition):
Pinto, P. M. G. (2009). Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pinto, Paula Maria Gonçalves . “Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?.” 2009. Thesis, Universidade Nova. Accessed March 04, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pinto, Paula Maria Gonçalves . “Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?.” 2009. Web. 04 Mar 2021.
Vancouver:
Pinto PMG. Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?. [Internet] [Thesis]. Universidade Nova; 2009. [cited 2021 Mar 04].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pinto PMG. Síndrome de apneia hipopneia obstrutiva do sono e óxido nítrico : que relação ?. [Thesis]. Universidade Nova; 2009. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5522
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Central Connecticut State University
22.
Gagnon, Victoria Lee.
Obstructive Sleep Apnea Syndrome and Associated Health Risks.
Degree: Department of Biology, 2008, Central Connecticut State University
URL: http://content.library.ccsu.edu/u?/ccsutheses,1031
► Sleep apnea syndrome is a disease that has become increasing more prevalent in the United States in the past fifty years. Because of the newness…
(more)
▼ Sleep apnea syndrome is a disease that has become increasing more prevalent in the United States in the past fifty years. Because of the newness of this disease it can often be misdiagnosed or even completely missed in individuals.
Sleep apnea syndrome poses many complications to individuals that have it, but as this review will show with the proper treatment and/or weight loss most of the complications will diminish or be completely resolved. Because of this it is important to know the signs, symptoms and what predisposes patients to
sleep apnea so it can be properly diagnosed and patients can receive treatment. Individuals with
sleep apnea are at risk for several complications. Glucose metabolism disorders and cardiac complications are the main complications that patients face. Along with these complications patients may also experience increased sleepiness and depression which can affect patients in how they are able to function in their daily lives. This thesis is a literature review which attempts to bring together many aspects of
sleep apnea into a comprehensive review. This thesis will discuss the types of
sleep apnea and general background, what can predispose an individual to and the risks of
sleep apnea, the complications that
sleep apnea can cause, and what options are available to treat and control
sleep apnea, in hopes of making people more aware of the disease and the treatment options that are available.
Advisors/Committee Members: Rollin, Ruth;.
Subjects/Keywords: Sleep apnea syndromes
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APA (6th Edition):
Gagnon, V. L. (2008). Obstructive Sleep Apnea Syndrome and Associated Health Risks. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,1031
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gagnon, Victoria Lee. “Obstructive Sleep Apnea Syndrome and Associated Health Risks.” 2008. Thesis, Central Connecticut State University. Accessed March 04, 2021.
http://content.library.ccsu.edu/u?/ccsutheses,1031.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gagnon, Victoria Lee. “Obstructive Sleep Apnea Syndrome and Associated Health Risks.” 2008. Web. 04 Mar 2021.
Vancouver:
Gagnon VL. Obstructive Sleep Apnea Syndrome and Associated Health Risks. [Internet] [Thesis]. Central Connecticut State University; 2008. [cited 2021 Mar 04].
Available from: http://content.library.ccsu.edu/u?/ccsutheses,1031.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gagnon VL. Obstructive Sleep Apnea Syndrome and Associated Health Risks. [Thesis]. Central Connecticut State University; 2008. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1031
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – San Francisco
23.
Asghari, Sara.
A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population.
Degree: Oral and Craniofacial Sciences, 2013, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/4j93r18c
► IntroductionObstructive sleep apnea (OSA) is characterized by breathing disturbances during sleep, and daytime sleepiness.1 Prevalence of OSA has been cited as 3-33% for men and…
(more)
▼ IntroductionObstructive sleep apnea (OSA) is characterized by breathing disturbances during sleep, and daytime sleepiness.1 Prevalence of OSA has been cited as 3-33% for men and 2-9% for women.2-4 Risk factors for OSA include obesity, male gender, age, neck circumference, high blood pressure, and specific craniofacial anomalies.1,2,5,6 Craniofacial findings in OSA patients include an inferiorly-positioned hyoid relative to the mandibular plane, a relatively shorter maxilla and mandible, larger overjet, an increased mandibular plane angle, and an increased ANB angle.7-10 Our hypothesis is that in an adult orthodontic patient population, specific skeletal cephalometric measurements can distinguish between OSA high-risk and low-risk patients, and that there is a preventive effect of orthognathic surgery in young adulthood for developing OSA later in life. Materials and MethodsWe conducted a cross-sectional study evaluating OSA risk in adult orthodontic and orthognathic surgery patients from the UCSF Orthodontic and Oral and Maxillofacial Surgery clinics. We used a questionnaire composed of the Berlin Questionnaire (BQ), and the Epworth Sleepiness Scale (ESS) to assess the risk of OSA. Each orthodontic subject's lateral cephalogram was digitized. Logistic regression was used to evaluate the association between the subjects' specific cephalometric measurements, and the results of the BQ and ESS. Results27 orthodontic subjects and 28 surgical subjects were included. In the orthodontic group, none of the female subjects and 4 of the male subjects scored `high-risk' on the BQ. Male gender (p < 0.05) was found to be significantly associated with being classified as `high-risk' by the BQ in the orthodontic patient group. No difference was found in the BQ and ESS results of the orthodontic and surgical groups. The mandibular plane to hyoid distance (MPH) was found to be moderately associated with being classified as `high-risk' by the BQ (p < 0.1). Conclusions1. Our questionnaire serves as an excellent screening tool for orthodontic patients. 2. Prevalence of probable OSA was found to be 40% for males and in 0% of the females in this study's orthodontic patient population.3. There is a positive association between likelihood of OSA and the following factors: male gender, and an inferiorly-positioned hyoid.
Subjects/Keywords: Dentistry; Adult; Apnea; Obstructive; Orthodontic; Patient; Sleep
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APA (6th Edition):
Asghari, S. (2013). A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/4j93r18c
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Asghari, Sara. “A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population.” 2013. Thesis, University of California – San Francisco. Accessed March 04, 2021.
http://www.escholarship.org/uc/item/4j93r18c.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Asghari, Sara. “A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population.” 2013. Web. 04 Mar 2021.
Vancouver:
Asghari S. A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population. [Internet] [Thesis]. University of California – San Francisco; 2013. [cited 2021 Mar 04].
Available from: http://www.escholarship.org/uc/item/4j93r18c.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Asghari S. A Cross-Sectional Study Evaluating the Risk of Obstructive Sleep Apnea in an Orthodontic Adult Patient Population. [Thesis]. University of California – San Francisco; 2013. Available from: http://www.escholarship.org/uc/item/4j93r18c
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
24.
Kwon, Younghoon.
Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis.
Degree: MS, Clinical Research, 2014, University of Minnesota
URL: http://hdl.handle.net/11299/165557
► Background: Obstructive sleep apnea (OSA) is a common condition believed to be linked to cardiovascular comorbidities. Its potential effect on progression of subclinical atherosclerosis is…
(more)
▼ Background: Obstructive sleep apnea (OSA) is a common condition believed to be linked to cardiovascular comorbidities. Its potential effect on progression of subclinical atherosclerosis is not well studied. We tested the hypothesis that OSA is associated with progression of coronary artery calcium (CAC) score. We also evaluated whether traditional cardiovascular risk factors mediated the association. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective epidemiologic cohort which has had a total of 5 clinic visits. Our primary analytic sample included 2,603 participants who at or near visit 2 (2002-2004) completed a sleep questionnaire and underwent coronary computerized tomography (CT), and underwent a repeat coronary CT approximately 8 years later (Visit 5: 2010-2011). Participants were categorized by their self-reported sleep breathing history: OSA: n= 102; Habitual snore: n = 666; Normal: n= 1835. mean age: 61.2).Results: Absolute CAC scores varied at visit 2, with the highest CAC prevalence among those with OSA, and lower but similar CAC prevalences among those who were habitual snorers or normal. Over 8 years of follow-up, greater progression of CAC was observed among those with OSA vs. those classified as normal (mean increase of 227.7 vs.135.6 Agatston units). This difference persisted after adjustment for BMI but was not significant after adjustment for cardiovascular risk factors (138.2 vs. 185.9 Agatston units; p = 0.08). CAC progression among habitual snorers was similar to that observed in the normal group.Conclusion: Self-reported sleep apnea was associated with CAC score progression after adjustment for demographics, behaviors and BMI. However, the association was not significant after accounting for cardiovascular risk factors which may mediate the association between OSA and CAC.
Subjects/Keywords: Coronary artery calcium; Sleep apnea; Snoring
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APA (6th Edition):
Kwon, Y. (2014). Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/165557
Chicago Manual of Style (16th Edition):
Kwon, Younghoon. “Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis.” 2014. Masters Thesis, University of Minnesota. Accessed March 04, 2021.
http://hdl.handle.net/11299/165557.
MLA Handbook (7th Edition):
Kwon, Younghoon. “Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis.” 2014. Web. 04 Mar 2021.
Vancouver:
Kwon Y. Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis. [Internet] [Masters thesis]. University of Minnesota; 2014. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/11299/165557.
Council of Science Editors:
Kwon Y. Sleep apnea and progression of coronary artery calcium: the multi-ethnic study of atherosclerosis. [Masters Thesis]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/165557
University of New Mexico
25.
Alcock, John.
The effect of sympathetic activation on gut microbiota in obstructive sleep apnea.
Degree: Biomedical Sciences Graduate Program, 2013, University of New Mexico
URL: https://digitalrepository.unm.edu/biom_etds/75
► Background: Patients with obstructive sleep apnea (OSA) suffer from increased mortality because of complications from metabolic and cardiovascular disease. Excess sympathetic nervous activity and catecholamine…
(more)
▼ Background: Patients with obstructive
sleep apnea (OSA) suffer from increased mortality because of complications from metabolic and cardiovascular disease. Excess sympathetic nervous activity and catecholamine exposure contribute to the disease associations of OSA, but the underlying mechanism remains enigmatic. Because catecholamines cause overgrowth of bacteria in the class Enterobacteriaceae in the laboratory, this translational study proposed a role for altered gut microbiota in the complications of OSA. Objectives: We tested the hypothesis that catecholamine excess in disordered
sleep alters intestinal microbiota by comparing urinary catecholamines and the fecal microbiome of 24 patients with obstructive
sleep apnea and 23 controls. Results: Next-generation sequencing of the gut microbiome using the Illumina platform provided evidence for a trend toward altered community structure of gut microbiota in patients with
sleep apnea. A positive linear relationship was seen in norepinephrine exposure and Enterobacteriaceae in patients with
sleep apnea, but no such relationship occurred in controls. Conclusions: These findings provide preliminary support for a central role of gut microbiota in the complications of
sleep.
Advisors/Committee Members: Lin, Henry, Shuttleworth, William, Villareal, Dennis, Lin, Henry.
Subjects/Keywords: Microbiota; Obstructive Sleep Apnea; Catecholamines; Inflammation; Metabolism
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APA (6th Edition):
Alcock, J. (2013). The effect of sympathetic activation on gut microbiota in obstructive sleep apnea. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/75
Chicago Manual of Style (16th Edition):
Alcock, John. “The effect of sympathetic activation on gut microbiota in obstructive sleep apnea.” 2013. Masters Thesis, University of New Mexico. Accessed March 04, 2021.
https://digitalrepository.unm.edu/biom_etds/75.
MLA Handbook (7th Edition):
Alcock, John. “The effect of sympathetic activation on gut microbiota in obstructive sleep apnea.” 2013. Web. 04 Mar 2021.
Vancouver:
Alcock J. The effect of sympathetic activation on gut microbiota in obstructive sleep apnea. [Internet] [Masters thesis]. University of New Mexico; 2013. [cited 2021 Mar 04].
Available from: https://digitalrepository.unm.edu/biom_etds/75.
Council of Science Editors:
Alcock J. The effect of sympathetic activation on gut microbiota in obstructive sleep apnea. [Masters Thesis]. University of New Mexico; 2013. Available from: https://digitalrepository.unm.edu/biom_etds/75
University of Arizona
26.
Morales, Efreim Joseph Dela Cruz.
Obstructive Sleep Apnea and the Gut Microbiome
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/631465
► We investigated how the combined influence of intermittent hypoxia (IH) and high-fat diet (HFD)—modelling obstructive sleep apnea (OSA)—can induce gut microbiota dysbiosis and alter host…
(more)
▼ We investigated how the combined influence of intermittent hypoxia (IH) and high-fat diet (HFD)—modelling obstructive
sleep apnea (OSA)—can induce gut microbiota dysbiosis and alter host gene expression. The study involved 16 mice randomly assigned to four experimental groups receiving distinct treatments as follows: normoxia-normal diet (NM-ND), normoxia-high-fat diet (NM-HFD), intermittent hypoxia-normal diet (IH-ND) and intermittent hypoxia-high-fat diet (IH-HFD). IH-treated mice were subjected to ten IH cycles per hour (six-minute cycles, first three at 9% O2 and the next three at 21% O2). Mucosa and fecal microbiota were characterized by pyrosequencing of the hypervariable V4 region of the 16S ribosomal RNA and analyzed via Quantitative Insights into Microbial Ecology (QIIME) software package. Host response was analyzed through microarray analysis of colonic genes. Nevertheless, the focus of the experiment’s microbiome and microarray analysis shifted to the proximal colon. Alpha-diversity and beta-diversity analysis of the mucosal and fecal microbiota suggested a more potent impact of HFD on distinct differences in bacterial profile, accompanied by an increase in Firmicute:Bacteroidetes ratio. Bacterial community profiles in the proximal colon were demonstrated to have more significant (p<0.05) dissimilarities in contrast to the distal colon. We found that members of the same taxa behaved differently; more specifically the Peptostreptococcaceae family and the Lachnospiraceae family (both from the Firmicute phylum) grew in abundance on HFD but decreased and increased in numbers, respectively, with the added treatment of IH. Two-way ANOVA on samples calculated that dietary content had the most significant (p < 0.05) impact on gene expression; followed by the combined impact of diet and oxygen status, and then oxygen status alone. Furthermore, gene ontology (GO) analysis revealed significant (p < 0.05) biological functions (ex. cell-to-cell adhesion) while gene set analysis (GSA) further identified the genes (ex. Cldn2, -4 and -15) that may be responsible for regulating these altered processes. Taken together, the combined impact of IH and HFD on the gut microbiota significantly caused dysbiosis on a specific site more than another (proximal colon versus distal colon, respectively), had varied effects on different taxonomic levels and elicited changes on host gene expression involved in intestinal impermeability—playing a key role in immune and metabolic responses that may underlie disease.
Advisors/Committee Members: St. John, Paul (advisor), Kiela, Pawel (committeemember), Pace, Thaddeus (committeemember), Parthasarathy, Sairam (committeemember).
Subjects/Keywords: Apnea;
Gut;
Microbiome;
Obesity;
Obstructive;
Sleep
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APA (6th Edition):
Morales, E. J. D. C. (2018). Obstructive Sleep Apnea and the Gut Microbiome
. (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/631465
Chicago Manual of Style (16th Edition):
Morales, Efreim Joseph Dela Cruz. “Obstructive Sleep Apnea and the Gut Microbiome
.” 2018. Masters Thesis, University of Arizona. Accessed March 04, 2021.
http://hdl.handle.net/10150/631465.
MLA Handbook (7th Edition):
Morales, Efreim Joseph Dela Cruz. “Obstructive Sleep Apnea and the Gut Microbiome
.” 2018. Web. 04 Mar 2021.
Vancouver:
Morales EJDC. Obstructive Sleep Apnea and the Gut Microbiome
. [Internet] [Masters thesis]. University of Arizona; 2018. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10150/631465.
Council of Science Editors:
Morales EJDC. Obstructive Sleep Apnea and the Gut Microbiome
. [Masters Thesis]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/631465
University of Arizona
27.
ARBALLO, JESUS MARVIN.
Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/628040
► Background: Sleep apnea is a common health disorder that is strongly associated with many serious comorbidities. At Patel Medical Clinic located in rural southwestern Arizona,…
(more)
▼ Background:
Sleep apnea is a common health disorder that is strongly associated with many serious comorbidities. At Patel Medical Clinic located in rural southwestern Arizona, the clinic director acknowledged the need to identify individuals that may have this condition but may go undetected. Presentation of symptoms in women can be misleading for diagnosis and conceals the need for further workup. Although men are more commonly recognized for having this condition, women of 50 years of age and older are vulnerable as the risk for
sleep apnea increases significantly after menopause. In this study, women 50 years of age and older were asked to volunteer to determine
sleep apnea risk and to identify barriers to diagnosis.
Methods
The purpose of this quality improvement project was to evaluate the use of a validated screening tool in identifying women 50 years of age and older in a rural southwestern internal medicine practice who are at moderate to high-risk of
sleep apnea using a cross-sectional quantitative survey design. The study took place at Patel Medical Clinic, a private medical establishment located in rural Arizona. All clinic patients who are female and 50 years of age and older and patients of this clinic during data collection times were able to participate in the study, regardless of
sleep apnea status.
Results
Most participants were of the 60-69 and 70-79 age groups. Study subjects consisted of 54 women. Of these, (37) 68.5% of participants scored at moderate or high-risk of
sleep apnea. A total of (27) 50% participants scored as “moderate-risk,” (10) 18.5% scored as high-risk. Of the 54 participants, (13) 24% had a previous diagnosis of
sleep apnea. Of those 13 with an established diagnosis, (7) 53% scored in the moderate-risk category, and (5) 38 % scored in the high-risk category. Out of those that were referred for
sleep study but unable to participate, various barriers were identified that were unique to each individual participant.
Discussion/Recommendations
Symptoms of
sleep apnea are vastly present among participants. Many participants that scored as having moderate to high-risk have not been referred for
sleep study. A screening tool could potentially reduce the number of moderate-to-high-risk patients from going unrecognized. Additional long-term studies are necessary to further examine barriers for diagnostic testing and how to better ensure that these tests are completed. Women with
sleep apnea often present with gender-specific symptoms and could greatly benefit from a female-focused questionnaire.
Advisors/Committee Members: Pacheco, Christy (advisor), Brown, Angela (committeemember), Daly, Patricia (committeemember).
Subjects/Keywords: post menopause;
rural;
screening;
sleep apnea;
Women
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APA (6th Edition):
ARBALLO, J. M. (2018). Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/628040
Chicago Manual of Style (16th Edition):
ARBALLO, JESUS MARVIN. “Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
.” 2018. Doctoral Dissertation, University of Arizona. Accessed March 04, 2021.
http://hdl.handle.net/10150/628040.
MLA Handbook (7th Edition):
ARBALLO, JESUS MARVIN. “Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
.” 2018. Web. 04 Mar 2021.
Vancouver:
ARBALLO JM. Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
. [Internet] [Doctoral dissertation]. University of Arizona; 2018. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10150/628040.
Council of Science Editors:
ARBALLO JM. Sleep Apnea in Women Aged 50 Years and Older. A Cross Sectional Quantitative Survey in a Rural Clinic in Southern Arizona
. [Doctoral Dissertation]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/628040
University of Arizona
28.
Breslin, Jennifer H.
Sleep Disturbance, Cognition, and Behavior in Down Syndrome
.
Degree: 2011, University of Arizona
URL: http://hdl.handle.net/10150/201494
► Children and adolescents with Down Syndrome (DS) have a high incidence of sleep problems, including Obstructive Sleep Apnea Syndrome (OSAS). They are also likely to…
(more)
▼ Children and adolescents with Down Syndrome (DS) have a high incidence of
sleep problems, including Obstructive
Sleep Apnea Syndrome (OSAS). They are also likely to have deficits in neuropsychological tasks tapping prefrontal function and hippocampal function. There has recent revival of literature suggesting an active role for
sleep in memory consolidation and problem-solving in both children and adults. Furthermore, given the cognitive and behavioral sequellae of OSAS in typically developing children it is logical to test if the hypoxemia and increased
sleep fragmentation, the two major pathophysiological mechanisms of OSAS, seen in children with DS and OSAS may exacerbate learning or behavior disorders.Forty children with DS aged 7-18 were administered the Arizona Cognitive Test Battery (ACTB) for DS (Edgin et al., 2010), and in-home ambulatory polysomnography. Their parents were asked to complete several questionnaires assessing their child's
sleep and behavior. Seventy-seven percent (n = 40) of our sample met criteria for pediatric
sleep apnea (AHI>1.5), and the mean
apnea hypoppnea index (AHI) was 8.4 events per hour. Our sample had a mean arousal index of 10.3, a respiratory arousal index of 3.2, and a SaO2 nadir of 86.9%. Over 70% of our sample had a SaO2 nadir below 90%. We examined the relationship between OSAS severity and cognitive and behavioral outcomes. We found that children with DS with a lower
apnea hypopnea index (AHI) attained a greater number of stages on the CANTAB PAL task compared to chronologically age-matched children with higher AHI, and the variance in performance was partially explained by
sleep fragmentation (i.e., the arousal index) and experimenter-rated "attention" but not hypoxemia. In addition, we also found that the low
apnea group showed a trend toward outperforming the high
apnea group on the KBIT-II Verbal IQ scale and DAS-2 Pattern Construction subtest.These findings have important clinical implications. First, these results suggest that early screening for OSAS in DS is important, as OSAS severity seems to explain some of the variance in cognitive functioning. Second, these findings suggest that an early intervention for OSAS might be warranted.
Advisors/Committee Members: Bootzin, Richard R (advisor), Nadel, Lynn (advisor), Ryan, T. Lee (advisor), Allen, John J.B. (committeemember), Perfect, Michelle M. (committeemember), Bootzin, Richard R. (committeemember), Nadel, Lynn (committeemember), Ryan, T. Lee (committeemember).
Subjects/Keywords: Down syndrome;
Sleep;
Psychology;
Apnea;
Cognition
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APA (6th Edition):
Breslin, J. H. (2011). Sleep Disturbance, Cognition, and Behavior in Down Syndrome
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/201494
Chicago Manual of Style (16th Edition):
Breslin, Jennifer H. “Sleep Disturbance, Cognition, and Behavior in Down Syndrome
.” 2011. Doctoral Dissertation, University of Arizona. Accessed March 04, 2021.
http://hdl.handle.net/10150/201494.
MLA Handbook (7th Edition):
Breslin, Jennifer H. “Sleep Disturbance, Cognition, and Behavior in Down Syndrome
.” 2011. Web. 04 Mar 2021.
Vancouver:
Breslin JH. Sleep Disturbance, Cognition, and Behavior in Down Syndrome
. [Internet] [Doctoral dissertation]. University of Arizona; 2011. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10150/201494.
Council of Science Editors:
Breslin JH. Sleep Disturbance, Cognition, and Behavior in Down Syndrome
. [Doctoral Dissertation]. University of Arizona; 2011. Available from: http://hdl.handle.net/10150/201494
29.
Shafer, Brooke Marie.
The implications of undiagnosed obstructive sleep apnea on resting hemodynamic variables in cardiac rehabilitation patients.
Degree: 2013, James Madison University
URL: https://commons.lib.jmu.edu/master201019/322
► The primary objective of this study was to examine the effects of obstructive sleep apnea (OSA) on resting hemodynamic variables pre- and post-cardiac rehabilitation (CR).…
(more)
▼ The primary objective of this study was to examine the effects of obstructive sleep apnea (OSA) on resting hemodynamic variables pre- and post-cardiac rehabilitation (CR). Subjects were screened for OSA using an at-home screening device. Subjects were then divided into two design groups: subjects with likely OSA (OSA) and subjects without OSA (non-OSA). All patients had resting hemodynamic measurements recorded and performed a 6-minute walk test. Resting hemodynamics and 6-minute walk test were performed pre- and post-CR. The study was conducted at Rockingham Memorial Hospital in Harrisonburg, VA and Carilion Roanoke Community Hospital in Roanoke, VA where subjects completed standard early-outpatient (Phase II) Cardiac Rehabilitation. The sample consisted of 33 OSA subjects (age: 65.0 ± 12.4 years; AHI: 17.2 ± 12.3) and 12 non-OSA subjects (age: 63.7 ± 11.2 years; AHI: 1.8 ±1.3). Both the OSA and the non- OSA group had a significant improvement in BMI (p= 0.046) from baseline measurements to follow-up without a significant difference between groups. Both groups significantly improved 6-minute walk test performance (p<0.0001) from baseline to follow-up, with the OSA group having significantly higher values at both time points. The OSA group had significantly lower cardiac index values (p=0.018), ejection fraction values (p=0.039), and contractility index values (p=0.008) when compared to the non OSA group at baseline and follow-up. The OSA group had significantly higher systemic vascular resistance index values (p=0.027) when compared to the non-OSA group at baseline and follow-up. There was no significant effect for time or group by time with respect to any other variable. CR can facilitate in BMI improvement, while potentially improving vi cardiovascular fitness in patients. CR did not improve resting hemodynamic variables, regardless of OSA presence. However, subjects with OSA appear to have diminished cardiac function when compared to non-OSA subjects, manifesting through increased systemic vascular resistance index and decreased contractility index, cardiac index, and ejection fraction.
Subjects/Keywords: obstructive sleep apnea; hemodynamics; cardiac rehabilitation; Kinesiology
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APA (6th Edition):
Shafer, B. M. (2013). The implications of undiagnosed obstructive sleep apnea on resting hemodynamic variables in cardiac rehabilitation patients. (Masters Thesis). James Madison University. Retrieved from https://commons.lib.jmu.edu/master201019/322
Chicago Manual of Style (16th Edition):
Shafer, Brooke Marie. “The implications of undiagnosed obstructive sleep apnea on resting hemodynamic variables in cardiac rehabilitation patients.” 2013. Masters Thesis, James Madison University. Accessed March 04, 2021.
https://commons.lib.jmu.edu/master201019/322.
MLA Handbook (7th Edition):
Shafer, Brooke Marie. “The implications of undiagnosed obstructive sleep apnea on resting hemodynamic variables in cardiac rehabilitation patients.” 2013. Web. 04 Mar 2021.
Vancouver:
Shafer BM. The implications of undiagnosed obstructive sleep apnea on resting hemodynamic variables in cardiac rehabilitation patients. [Internet] [Masters thesis]. James Madison University; 2013. [cited 2021 Mar 04].
Available from: https://commons.lib.jmu.edu/master201019/322.
Council of Science Editors:
Shafer BM. The implications of undiagnosed obstructive sleep apnea on resting hemodynamic variables in cardiac rehabilitation patients. [Masters Thesis]. James Madison University; 2013. Available from: https://commons.lib.jmu.edu/master201019/322
Georgia State University
30.
McArthur, Dedria.
Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients.
Degree: MPH, Public Health, 2016, Georgia State University
URL: https://scholarworks.gsu.edu/iph_theses/469
► Background: Obstructive Sleep Apnea (OSA) is a chronic breathing disorder that is estimated to affect 20% of the US adult population. Intermittent hypoxia and…
(more)
▼ Background: Obstructive
Sleep Apnea (OSA) is a chronic breathing disorder that is estimated to affect 20% of the US adult population. Intermittent hypoxia and
sleep fragmentation caused by OSA likely affects cardiometabolic function. Individuals with OSA might be at risk of developing hypertension and type 2 diabetes (T2DM), with a dose-response relationship related to OSA severity. The objective of this study was to estimate the association between severity of OSA at diagnosis with 1) incidence of hypertension incidence of hypertension and 2) incidence of T2DM.
Methods: We conducted a retrospective cohort study of Kaiser Permanente members diagnosed with OSA during 2000-2005. Adults without baseline hypertension or T2DM were eligible. Patients were excluded if hypertension or T2DM was diagnosed within one year prior to OSA diagnosis, and right censored at the end of follow-up or at the time Kaiser Permanente membership ended. Kaplan-Meier curves and Cox Proportional Hazard models were used to estimate the association between OSA severity and incident hypertension and incident diabetes.
Results: Overall 719 patients were diagnosed with OSA during the study periods; 614 were included as those at risk of developing either hypertension (N=265) or T2DM (N=489). Overall, 261 had severe OSA at diagnosis. Those with severe OSA were more likely to be middle aged, overweight, and have prevalent hypertension or T2DM. Among those without prevalent hypertension at OSA diagnosis, 47.4% (126/266) were subsequently diagnosed with hypertension. Among those without prevalent T2DM at OSA diagnosis, 16.3% (80/491) were subsequently diagnosed with T2DM. After adjusting for BMI and prevalent T2DM, the hazard rate of incident hypertension among patients with severe OSA was 1.35 (95%CI: 0.88-2.06) compared to the rate among patients with mild OSA. The hazard rate of incident T2DM among patients with severe OSA was 1.49 (95%CI: 0.83-2.67) compared to the rate among patients with mild OSA after adjusting for BMI and prevalent hypertension.
Discussion: We found high incidence rates of hypertension and T2DM among adults diagnosed with OSA. Severe OSA at diagnosis was associated with increased risk of either incident hypertension or T2DM, but not significantly (for p≤0.05).
Advisors/Committee Members: Dr. Roblin Magee, Dr. Matthew Magee.
Subjects/Keywords: Obstructive sleep apnea; hypertension; type 2 diabetes
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APA (6th Edition):
McArthur, D. (2016). Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/469
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McArthur, Dedria. “Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients.” 2016. Thesis, Georgia State University. Accessed March 04, 2021.
https://scholarworks.gsu.edu/iph_theses/469.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McArthur, Dedria. “Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients.” 2016. Web. 04 Mar 2021.
Vancouver:
McArthur D. Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients. [Internet] [Thesis]. Georgia State University; 2016. [cited 2021 Mar 04].
Available from: https://scholarworks.gsu.edu/iph_theses/469.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McArthur D. Incidence of Hypertension and Type 2 Diabetes Among Obstructive Sleep Apnea Patients. [Thesis]. Georgia State University; 2016. Available from: https://scholarworks.gsu.edu/iph_theses/469
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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. 
Open Access Theses and Dissertations