subject:(Skull base)

University of Adelaide

1. Padhye, Vikram. Management of major vessel haemorrhage in endonasal surgery.

Degree: 2015, University of Adelaide

URL: http://hdl.handle.net/2440/119559

► Introduction Endoscopic endonasal surgery (EES) is fast becoming the method of choice to address pathology of the paranasal sinuses and skull base. It carries with… (more)

▼ Introduction Endoscopic endonasal surgery (EES) is fast becoming the method of choice to address pathology of the paranasal sinuses and skull base. It carries with it advantages in regards to visualization, magnification, avoidance of scars, reduced length of stay and patient morbidity. With its greater utilization there needs to be an appreciation of its potential limitations as well. The most feared and potentially catastrophic complication for the endoscopic surgeon is that of inadvertent carotid artery injury (CAI). This represents a challenging surgical environment, a high pressure / high flow haemorrhagic scenario which can result in exsanguination of the patient. Current treatment recommendations, such as nasal packing, can result in increased patient morbidity. Despite acute management, patients may still be at risk in the long term due to the potential of vessel spasm, thrombosis, cerebral insult secondary to embolism, pseudoaneurysm or even carotico-cavernous fistula formation. The aims of the studies presented in this thesis are to develop and evaluate safe endoscopic haemostatic techniques on different injury types, explore their mechanisms of action, report on the value of training surgeons in these techniques, while assessing the success of their use in the clinical setting. Methods A sheep model of carotid artery injury was employed to simulate the high pressure / high flow arterial bleeding environment. This allowed for different endoscopic haemostats such as a crushed muscle patch, aneurysm clip and bipolar cautery, to be randomised and evaluated on different injury types. The muscle patch was assessed further on a series of large animal carotid lacerations, which were harvested at different time points and histologically analysed. The direct vessel closure technique in the form the AnastoClip (LeMaitre, Burlington, MA) was evaluated in a separate prospective large animal study. A retrospective review of surgeons who had undergone vascular injury training in our workshops who subsequently managed a CAI was conducted to evaluate the outcomes after vascular injury training. Results A crushed muscle patch and aneurysm clip proved to be effective in gaining haemostasis in the endoscopic carotid haemorrhage setting as well as maintaining normal carotid characteristics in the long-term. The success of the crushed muscle patch appears to be due to its ability to provide a seal of the vessel injury site and promote platelet aggregation, which is compounded by an acute and chronic tissue healing response. The AnastoClip was successful in gaining control of high pressure / high flow bleeding and maintains carotid patency in the long-term with minimal endoluminal penetration. Vascular injury trained surgeons are able to appropriately manage this catastrophic situation, a review of their CAI cases revealed a mortality rate of 0% with no permanent morbidity for their patients. Conclusions Studies presented in this thesis present evidence for new endoscopic haemostatic techniques. These have proved to be effective… Advisors/Committee Members: Wormald, Peter John (advisor), Vreugde, Sarah (advisor), School of Medicine (school).

Subjects/Keywords: carotid; haemostat; skull base; endoscopic surgery

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APA (6^th Edition):

Padhye, V. (2015). Management of major vessel haemorrhage in endonasal surgery. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Padhye, Vikram. “Management of major vessel haemorrhage in endonasal surgery.” 2015. Thesis, University of Adelaide. Accessed April 21, 2021. http://hdl.handle.net/2440/119559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Padhye, Vikram. “Management of major vessel haemorrhage in endonasal surgery.” 2015. Web. 21 Apr 2021.

Vancouver:

Padhye V. Management of major vessel haemorrhage in endonasal surgery. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/2440/119559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Padhye V. Management of major vessel haemorrhage in endonasal surgery. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/119559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

2. Lalani, Sara. Three-dimensional CBCT analysis of cranial base symmetry.

Degree: MSin Dentistry, Orthodontics and Dentofacial Orthopedics, 2015, Boston University

URL: http://hdl.handle.net/2144/37816

► Background: Craniofacial skeletal asymmetry is a common finding in the general population that often goes undetected. Interest in this topic has led to many studies… (more)

▼ Background: Craniofacial skeletal asymmetry is a common finding in the general population that often goes undetected. Interest in this topic has led to many studies aimed at describing this type of asymmetry, its distribution and etioIogy. The cranial base, being cIosely related to the face and brain, is a key component in craniofacial growth and may also display varying amounts of asymmetry contributing to this anomaly. Though many studies have explored underlying skeletal asymmetry, most of them were limited by their two-dimensional method of investigation. With the advent of three-dimensional technology, more recent studies have had the advantage of studying the cranial base in its true anatomic form, resulting in greater accuracy of analysis. Despite access to this technoIogy, there is still a lack of literature regarding the cranial base in a normal population. Determining average skull base dimensions will provide a set of normative data that can be used as a reference for future studies. Material and Methods: Pre-treatment Cone Beam Computed Tomography (CBCT) films of 160 esthetic human subjects previously used by another investigator were screened for use in our current research. These DICOM files were imported into InVivoDental5.3 software (Anatomage[TM]; San Jose, Calif.) for screening and 70 CBCT scans were selected for analysis. All patients were classified as cervical vertebral stage 4 and above. The images were oriented in all three planes of space for uniformity and 14 bilateral anatomic landmarks were identified on each scan. A mid-sagittal reference plane was created using crista galli as the origin, and extending a perpendicular passing through the middle of the right and left clinoid points connected by a line, and through posterior points basion and opisthion. Each landmark was given an x-, y- and z- coordinate representing its three dimensional position and bilateral linear measurements to the reference plane were recorded using the software system. Statistical Analysis: InVivoDental5.3 software was used to calculate linear distances between each landmark and the mid-sagittal plane. This data was exported into Microsoft excel for analysis. Descriptive statistics of our sample and paired t-tests with a 5% significance level, or p value of 0.05, were performed. Results: The means of the right and left measurements of each bilateral landmark were calculated along with their standard deviations. A comparison between right and left means was accomplished with the use of paired t-tests. 12 1andmarks did not show a statistical difference in their locations on either side of the mid-sagittal plane. However, the means of 2 landmarks were found to be statistically significant. These were euryon (p = 0.01) and the jugular foramen (p = 0.00) Conclusion: The overall trend of our data indicated that the cranial base in a normal population, without craniofacial anomaly, displays symmetry, with the exception of the location of euryon and the jugular foramen. These findings are in accordance with those of…

Subjects/Keywords: Cone-beam computed tomography; Skull base

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APA (6^th Edition):

Lalani, S. (2015). Three-dimensional CBCT analysis of cranial base symmetry. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/37816

Chicago Manual of Style (16^th Edition):

Lalani, Sara. “Three-dimensional CBCT analysis of cranial base symmetry.” 2015. Masters Thesis, Boston University. Accessed April 21, 2021. http://hdl.handle.net/2144/37816.

MLA Handbook (7^th Edition):

Lalani, Sara. “Three-dimensional CBCT analysis of cranial base symmetry.” 2015. Web. 21 Apr 2021.

Vancouver:

Lalani S. Three-dimensional CBCT analysis of cranial base symmetry. [Internet] [Masters thesis]. Boston University; 2015. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/2144/37816.

Council of Science Editors:

Lalani S. Three-dimensional CBCT analysis of cranial base symmetry. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/37816

University of Hong Kong

3. Tng, Thiam-huat. Validity of cephalometric landmarks.

Degree: 1991, University of Hong Kong

URL: http://hdl.handle.net/10722/50942

Subjects/Keywords: Skull - Radiography.; Skull base - Radiography.; Cephalometry.

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APA (6^th Edition):

Tng, T. (1991). Validity of cephalometric landmarks. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/50942

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tng, Thiam-huat. “Validity of cephalometric landmarks.” 1991. Thesis, University of Hong Kong. Accessed April 21, 2021. http://hdl.handle.net/10722/50942.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tng, Thiam-huat. “Validity of cephalometric landmarks.” 1991. Web. 21 Apr 2021.

Vancouver:

Tng T. Validity of cephalometric landmarks. [Internet] [Thesis]. University of Hong Kong; 1991. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10722/50942.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tng T. Validity of cephalometric landmarks. [Thesis]. University of Hong Kong; 1991. Available from: http://hdl.handle.net/10722/50942

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Wayhs, Samia Yasin. Influência da abordagem cirúrgica na ressecção dos meningiomas petroclivais.

Degree: 2015, Brazil

URL: http://hdl.handle.net/10183/148212

►

Meningiomas petroclivais são tumores da base do crânio desafiadores para ressecção cirúrgica devido a sua localização profunda e relação com estruturas neurovasculares vitais. Geralmente são… (more)

▼

Meningiomas petroclivais são tumores da base do crânio desafiadores para ressecção cirúrgica devido a sua localização profunda e relação com estruturas neurovasculares vitais. Geralmente são lesões benignas, mas podem envolver ou infiltrar o osso da base do crânio, dura-máter, tronco encefálico e todas as estruturas neurovasculares desta região, tornando a remoção total difícil sem causar déficits neurológicos. O objetivo deste estudo é revisar uma série de casos de meningiomas petroclivais tratados cirurgicamente em centro de referência de base de crânio, considerando os fatores determinantes para a escolha da abordagem. A casuística foi analisada com coleta retrospectiva dos dados. Devido à dificuldade de acesso, essas lesões geralmente requerem diferentes abordagens cirúrgicas e apresentam dificuldades cirúrgicas distintas. Embora as abordagens fronto-órbito-zigomática, petrosas, incluindo présigmoide retrolabiríntica, translabiríntica e petrosectomia total, e a retrossigmoide sejam as mais utilizadas para ressecção destes tumores, não foi realizado até o presente momento estudo comparativo que determine qual abordagem apresenta maior grau de ressecção cirúrgica associada a menor taxa de morbidade.

Petroclival meningiomas are challenging skull base tumors for surgical resection because of its deep location and their relationship to vital neurovascular structures. They are usually benign, but may involve or infiltrate the bone of the skull base, dura, brain stem and all neurovascular structures in this region, making it difficult to completely remove without causing neurological deficits. The aim of this study is to review a surgical series of petroclival meningioma treated in a referral center for skull base tumors, considering the determining factors to the choice of approach. The casuistry was analyzed with retrospective data collection. Due to difficult access, these injuries usually require different surgical approaches and have different surgical difficulties. Although the fronto-orbital-zygomatic, petrous, including retrolabyrinthine pre-sigmoid, translabyrinthine and total petrosectomy, and retrosigmoid are frequently used for resection of these tumors, it has not been realized to date comparative study to determine which approach has greater degree of surgical resection associated with lower morbidity rate.

Advisors/Committee Members: Isolan, Gustavo Rassier.

Subjects/Keywords: Meningioma; Neoplasias encefálicas; Base do crânio; Brain tumor; Surgical approach; Skull base; Petroclival meningioma; Clivus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wayhs, S. Y. (2015). Influência da abordagem cirúrgica na ressecção dos meningiomas petroclivais. (Masters Thesis). Brazil. Retrieved from http://hdl.handle.net/10183/148212

Chicago Manual of Style (16^th Edition):

Wayhs, Samia Yasin. “Influência da abordagem cirúrgica na ressecção dos meningiomas petroclivais.” 2015. Masters Thesis, Brazil. Accessed April 21, 2021. http://hdl.handle.net/10183/148212.

MLA Handbook (7^th Edition):

Wayhs, Samia Yasin. “Influência da abordagem cirúrgica na ressecção dos meningiomas petroclivais.” 2015. Web. 21 Apr 2021.

Vancouver:

Wayhs SY. Influência da abordagem cirúrgica na ressecção dos meningiomas petroclivais. [Internet] [Masters thesis]. Brazil; 2015. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10183/148212.

Council of Science Editors:

Wayhs SY. Influência da abordagem cirúrgica na ressecção dos meningiomas petroclivais. [Masters Thesis]. Brazil; 2015. Available from: http://hdl.handle.net/10183/148212

University of Nairobi

5. Bento, RF. Anatomy of the lateral base of the skull: development of a method of study .

Degree: 2005, University of Nairobi

URL: http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52024

► Introduction: Surgery of the lateral base of the skull is a medical specialty still in full development. There are few centers of excellence that have… (more)

Subjects/Keywords: lateral base of the skull

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APA (6^th Edition):

Bento, R. (2005). Anatomy of the lateral base of the skull: development of a method of study . (Thesis). University of Nairobi. Retrieved from http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bento, RF. “Anatomy of the lateral base of the skull: development of a method of study .” 2005. Thesis, University of Nairobi. Accessed April 21, 2021. http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bento, RF. “Anatomy of the lateral base of the skull: development of a method of study .” 2005. Web. 21 Apr 2021.

Vancouver:

Bento R. Anatomy of the lateral base of the skull: development of a method of study . [Internet] [Thesis]. University of Nairobi; 2005. [cited 2021 Apr 21]. Available from: http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bento R. Anatomy of the lateral base of the skull: development of a method of study . [Thesis]. University of Nairobi; 2005. Available from: http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

6. Vescan, Allan. Sinus and Skull Base Surgery Simulator - Development and Validation.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/70723

►

The acquisition of surgical skill has evolved dramatically over the last century. There has been a paradigm shift away from an apprenticeship model where learning… (more)

Subjects/Keywords: 3D Printing; Assessment; Simulation; Sinus; Skull Base; Virtual Reality; 0576

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vescan, A. (2015). Sinus and Skull Base Surgery Simulator - Development and Validation. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70723

Chicago Manual of Style (16^th Edition):

Vescan, Allan. “Sinus and Skull Base Surgery Simulator - Development and Validation.” 2015. Masters Thesis, University of Toronto. Accessed April 21, 2021. http://hdl.handle.net/1807/70723.

MLA Handbook (7^th Edition):

Vescan, Allan. “Sinus and Skull Base Surgery Simulator - Development and Validation.” 2015. Web. 21 Apr 2021.

Vancouver:

Vescan A. Sinus and Skull Base Surgery Simulator - Development and Validation. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/1807/70723.

Council of Science Editors:

Vescan A. Sinus and Skull Base Surgery Simulator - Development and Validation. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70723

NSYSU

7. Ko, Ching-Chung. Applications of Diffusion-Weighted MR Imaging in Brain Tumors.

Degree: PhD, Institute of Biomedical Sciences, 2018, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0416118-201726

► Although magnetic resonance imaging (MRI) had been used to diagnose brain tumors for a long time, the differentiation of brain tumors is still difficult in… (more)

Subjects/Keywords: meningioma; skull base; primary cerebral lymphoma; recurrence; ADC; DWI; glioblastoma multiforme

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ko, C. (2018). Applications of Diffusion-Weighted MR Imaging in Brain Tumors. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0416118-201726

Chicago Manual of Style (16^th Edition):

Ko, Ching-Chung. “Applications of Diffusion-Weighted MR Imaging in Brain Tumors.” 2018. Doctoral Dissertation, NSYSU. Accessed April 21, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0416118-201726.

MLA Handbook (7^th Edition):

Ko, Ching-Chung. “Applications of Diffusion-Weighted MR Imaging in Brain Tumors.” 2018. Web. 21 Apr 2021.

Vancouver:

Ko C. Applications of Diffusion-Weighted MR Imaging in Brain Tumors. [Internet] [Doctoral dissertation]. NSYSU; 2018. [cited 2021 Apr 21]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0416118-201726.

Council of Science Editors:

Ko C. Applications of Diffusion-Weighted MR Imaging in Brain Tumors. [Doctoral Dissertation]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0416118-201726

8. Jukes, Alistair Kenneth. Haemostasis in endoscopic skull base surgery.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/113617

► The endoscopic approach to the skull base has revolutionised surgery in this region. Neurosurgery involves working around anatomical structures that are uniquely sensitive to damage… (more)

▼ The endoscopic approach to the skull base has revolutionised surgery in this region. Neurosurgery involves working around anatomical structures that are uniquely sensitive to damage and manipulation and patients may be left with the potentially devastating consequences of violating these structures. The endoscope allows the surgeon to visualise and reach areas that were previously only accessible with large amounts of destructive dissection. Tumours are able to be removed and aneurysms clipped without the need for large craniotomies and bony drilling. There are, however, drawbacks. The midline endoscopic route takes the surgeon between the carotid arteries. It potentially violates the anterior communicating artery complex and the basilar artery region anterior to the brainstem. These are important arteries that supply critical structures. Damage to these, or diminution of blood flow through them, results in profound neurological dysfunction or death. The rate of damage to the carotid artery with these approaches ranges from 1.1-9% depending on the specific approach and pathology. The carotid artery in this region does not generally lend itself to suturing, clipping or direct closure methods. Currently, the gold standard for repair is the application of crushed muscle patch to stop the bleeding and seal the vessel. The drawbacks to this are that it takes time to harvest and control the bleed (generally requiring 2 surgeons), and that there is a risk of pseudoaneurysm formation post recovery. This thesis describes novel techniques that may replace the muscle patch in order that a single surgeon may have this technique available to them immediately. Aims: To demonstrate the use of fibrin/thrombin/gelatin patches, fibrin/thrombin glues, beta-chitosan patches and self-assembling peptides on a sheep model of carotid artery haemorrhage and quantify the rate of pseudoaneurysm formation. To show the percentage of platelets activated by crushed and uncrushed muscle, chitosan, and fibrin and thrombin patches and gels using flow cytometry to further delineate the mechanism of action of crushed muscle as a haemostatic agent. To quantify the stress response in surgeons training on this sheep vascular haemorrhage model de novo, to quantify its effect on surgeons’ teamwork and communication skills, and determine the effect and value of training on modulation of this stress response. Advisors/Committee Members: Wormald, Peter-John (advisor), Psaltis, Alkisviadis (advisor), Vreugde, Sarah (advisor), School of Medicine (school).

Subjects/Keywords: Research by publication; haemostasis; endoscopic surgery; skull base; chitin

10 more images…

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APA (6^th Edition):

Jukes, A. K. (2018). Haemostasis in endoscopic skull base surgery. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/113617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jukes, Alistair Kenneth. “Haemostasis in endoscopic skull base surgery.” 2018. Thesis, University of Adelaide. Accessed April 21, 2021. http://hdl.handle.net/2440/113617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jukes, Alistair Kenneth. “Haemostasis in endoscopic skull base surgery.” 2018. Web. 21 Apr 2021.

Vancouver:

Jukes AK. Haemostasis in endoscopic skull base surgery. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/2440/113617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jukes AK. Haemostasis in endoscopic skull base surgery. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/113617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. E. LA CORTE. CLINICAL AND MOLECULAR BIO-MARKERS IN SKULL BASE CHORDOMAS.

Degree: 2019, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/610397

► Introduzione. I cordomi della base cranica sono tumori rari e a lenta crescita derivanti dalla notocorda. La loro morbilità è principalmente legata alla loro invasione… (more)

▼ Introduzione. I cordomi della base cranica sono tumori rari e a lenta crescita derivanti dalla notocorda. La loro morbilità è principalmente legata alla loro invasione locale e alla resistenza ai trattamenti. A causa del loro aspetto eterogeneo e del loro comportamento clinico-molecolare non completamente compreso, l'obiettivo principale del presente lavoro è quello di identificare marcatori clinici e bio-molecolari come fattori prognostici specifici che potrebbero essere utilizzati per la corretta gestione di tali pazienti. Il raggiungimento di una firma prognostica dettagliata dei cordomi del basicranio è di fondamentale importanza per poter personalizzare il trattamento di ciascun paziente. Inoltre, l'analisi degli sfingolipidi sta emergendo come un nuovo approccio in molti tumori e non è mai stata applicata nei cordomi. L’obiettivo principale è lo studio del comportamento biologico del cordoma e il ruolo della produzione di ceramidi in questo contesto di proliferazione e invasione locale. Pazienti e Metodi. È stata eseguita una revisione retrospettiva di tutti i pazienti diagnosticati e trattati per cordoma della base cranica presso la Fondazione IRCCS Istituto Neurologico "Carlo Besta" tra il gennaio 1992 ed il dicembre 2017. Sono stati raccolti dati clinici, radiologici, chirurgici e patologici. È stata eseguita una raccolta prospettica di campioni chirurgici congelati per analizzare le specie di ceramidi. Gli sfingolipidi sono stati estratti dai tessuti congelati; i ceramidi e i diidroceramidi sono stati valutati mediante cromatografia liquida e spettrometria di massa. L'analisi di sopravvivenza è stata eseguita secondo il metodo di Kaplan-Meier. I confronti univariati sono stati condotti usando i test di Mann-Whitney, Chi-square e il test esatto di Fisher. Sono state condotte analisi di regressione e correlazione lineari. Utilizzando un modello di regressione logistica, i predittori statisticamente significativi sono stati pesati sulla base dei loro odds ratio al fine di sviluppare una scala personalizzata - la Peri-Operative Chordoma Scale (POCS). Risultati. Ottantasette pazienti sono stati trattati chirurgicamente per cordoma del basicranio. Settantotto pazienti sono stati dichiarati eleggibili per la revisione. I pazienti erano 38 maschi (48.7%) e 40 femmine (51.3%). Il follow-up medio era di 69 mesi (intervallo, 3-233). Sono stati eseguiti centoquattordici interventi chirurgici. La presenza di deficit motori si è rivelata essere un fattore prognostico significativo correlato a una PFS peggiore (p=0.0480). La presenza di calcificazioni ha mostrato una correlazione con risultati migliori di OS rispetto al tumore privo di calcificazioni (p=0.0420). Il grado di impregnazione contrastografica alla RM si è rivelato essere un fattore prognostico significativo in termini sia di OS che di PFS (p≤0.0001 e 0.0010, rispettivamente). Il coinvolgimento del forame giugulare e delle cisterne anteriori al tronco encefalico si sono rivelati due fattori prognostici significativi correlati con una riduzione di PFS (p=0.0130… Advisors/Committee Members: TUTOR: R. GHIDONI, COORDINATORE: R. GHIDONI, GHIDONI, RICCARDO, GHIDONI, RICCARDO.

Subjects/Keywords: ceramide; chordoma; prognostic factors; skull base surgery; Settore MED/27 - Neurochirurgia

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APA (6^th Edition):

CORTE, E. L. (2019). CLINICAL AND MOLECULAR BIO-MARKERS IN SKULL BASE CHORDOMAS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/610397

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

CORTE, E. LA. “CLINICAL AND MOLECULAR BIO-MARKERS IN SKULL BASE CHORDOMAS.” 2019. Thesis, Università degli Studi di Milano. Accessed April 21, 2021. http://hdl.handle.net/2434/610397.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

CORTE, E. LA. “CLINICAL AND MOLECULAR BIO-MARKERS IN SKULL BASE CHORDOMAS.” 2019. Web. 21 Apr 2021.

Vancouver:

CORTE EL. CLINICAL AND MOLECULAR BIO-MARKERS IN SKULL BASE CHORDOMAS. [Internet] [Thesis]. Università degli Studi di Milano; 2019. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/2434/610397.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

CORTE EL. CLINICAL AND MOLECULAR BIO-MARKERS IN SKULL BASE CHORDOMAS. [Thesis]. Università degli Studi di Milano; 2019. Available from: http://hdl.handle.net/2434/610397

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

10. Harvey, Richard. Endoscopic trans-nasal craniotomy.

Degree: Clinical School - St Vincent's Hospital, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/54265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:13757/SOURCE02?view=true

► The ventral skull base presents a unique surgical challenge. Disease is often closely associated with critical structures and morbidity from therapy can be high. The… (more)

▼ The ventral skull base presents a unique surgical challenge. Disease is often closely associated with critical structures and morbidity from therapy can be high. The main stay of anterior skull base approaches were combined trans-facial incisions with craniotomy. Skull base surgery is a dynamic subspecialty and the last decade has witnessed the application of endoscopic techniques to the ventral skull base using an endonasal corridor. The transition from external approaches to an endonasal corridor has not been without controversy. This thesis addresses several critical issues in managing skull base pathologies via an endoscopic trans-nasal craniotomy. The ability of the surgeon to remain orientated amongst a surgical field, which at first appears without landmarks, is critical. The orbital floor or maxillary line defines the skull base. This landmark is robust and provides safe passage in endoscopic surgery. The nasoseptal flap has revolutionised the ability to reliably reconstruct large skull base defects. However, data was lacking and a systematic review of the published outcomes from both free and vascularised skull base operations demonstrate the superiority of vascularised reconstructive tissue. The implications of nasoseptal harvest for subsequent sinonasal function were assessed using validated outcomes for patients, having had tumour surgery, with and without a nasoseptal flap. Sino-nasal function is not impaired long-term. The ability to modify the nasoseptal flap to reconstruct even small defects from pituitary surgery, without adversely affecting sino-nasal function, and particularly smell, was a critical step in refinement. Finally, a multi-centre study on endoscopic versus open surgical outcomes from the management of olfactory neuroblastoma was performed. This study demonstrated that even the most advanced tumours were being managed via endoscopic techniques with as good or better outcomes to traditional approaches. The ability to define the tumour site and achieve clear surgical resection margins may account for this observation. The endoscopic trans-nasal craniotomy has evolved dramatically in the past decade. The ability of the surgeon to locate the skull base, robustly reconstruct the defect, retain sino-nasal function and preserve smell are key advances. These evolutions have shifted the approach to difficult tumours, such as olfactory neuroblastoma and have improved the outcomes for patients with skull base pathologies. Advisors/Committee Members: Havas, Thomas, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Skull base; Endoscopic; Endoscopy; Surgery; Neurosurgery; Neuroblastoma; Septum; Reconstruction; Pituitary; Tumour

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APA (6^th Edition):

Harvey, R. (2015). Endoscopic trans-nasal craniotomy. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/54265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:13757/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Harvey, Richard. “Endoscopic trans-nasal craniotomy.” 2015. Doctoral Dissertation, University of New South Wales. Accessed April 21, 2021. http://handle.unsw.edu.au/1959.4/54265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:13757/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Harvey, Richard. “Endoscopic trans-nasal craniotomy.” 2015. Web. 21 Apr 2021.

Vancouver:

Harvey R. Endoscopic trans-nasal craniotomy. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Apr 21]. Available from: http://handle.unsw.edu.au/1959.4/54265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:13757/SOURCE02?view=true.

Council of Science Editors:

Harvey R. Endoscopic trans-nasal craniotomy. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/54265 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:13757/SOURCE02?view=true

University of Lund

11. Al-Shudifat, Abdul Rahman Mohummad. Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model.

Degree: 2017, University of Lund

URL: https://lup.lub.lu.se/record/24a3de0b-1dcd-44c8-a836-91f564249b51 ; https://portal.research.lu.se/ws/files/31510576/THESIS_DRAFTPsrevARMBrev170824em_6.pdf

► Skull base tumors comprise different pathological entities, making establishment of management guidelines challenging. All trials to define the ideal outcome measurement which can be reflected… (more)

Subjects/Keywords: Medical and Health Sciences; Skull base tumors; Vestibular schwannoma; Prognostic factors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al-Shudifat, A. R. M. (2017). Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/24a3de0b-1dcd-44c8-a836-91f564249b51 ; https://portal.research.lu.se/ws/files/31510576/THESIS_DRAFTPsrevARMBrev170824em_6.pdf

Chicago Manual of Style (16^th Edition):

Al-Shudifat, Abdul Rahman Mohummad. “Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model.” 2017. Doctoral Dissertation, University of Lund. Accessed April 21, 2021. https://lup.lub.lu.se/record/24a3de0b-1dcd-44c8-a836-91f564249b51 ; https://portal.research.lu.se/ws/files/31510576/THESIS_DRAFTPsrevARMBrev170824em_6.pdf.

MLA Handbook (7^th Edition):

Al-Shudifat, Abdul Rahman Mohummad. “Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model.” 2017. Web. 21 Apr 2021.

Vancouver:

Al-Shudifat ARM. Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model. [Internet] [Doctoral dissertation]. University of Lund; 2017. [cited 2021 Apr 21]. Available from: https://lup.lub.lu.se/record/24a3de0b-1dcd-44c8-a836-91f564249b51 ; https://portal.research.lu.se/ws/files/31510576/THESIS_DRAFTPsrevARMBrev170824em_6.pdf.

Council of Science Editors:

Al-Shudifat ARM. Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model. [Doctoral Dissertation]. University of Lund; 2017. Available from: https://lup.lub.lu.se/record/24a3de0b-1dcd-44c8-a836-91f564249b51 ; https://portal.research.lu.se/ws/files/31510576/THESIS_DRAFTPsrevARMBrev170824em_6.pdf

Universitat de Barcelona

12. Santamaría Gadea, Alfonso. Uso endoscópico del colgajo pericraneal para la reconstrucción nasal y de base de cráneo.

Degree: 2018, Universitat de Barcelona

URL: http://hdl.handle.net/10803/663441

► The pericranial flap (PCF) has been commonly used in craneo-facial and skull base reconstructions. However, the advance of endoscopic techniques has relegated the use of… (more)

▼ The pericranial flap (PCF) has been commonly used in craneo-facial and skull base reconstructions. However, the advance of endoscopic techniques has relegated the use of PCF. At the same time, this advance represents an opportunity to extend the indications of the PCF to those endoscopic approaches in which the endonasal flaps are not available. The aims of this study is to analyze the use of the PCF in the endoscopic reconstruction of the skull base and the nasal septum. An anatomical study on fresh cadaver specimens in which reconstructions of the different skull base defects and nasal septum were carried out. The PCF was introduced through an osteotomy of the frontal sinus. Then, the defects were endoscopically repair. A radiological analysis in computed tomography was performed. The reconstruction limits allowed by the PCF and the standardization of the size of the PCF according to the defect were measured. A clinical study is performed in patients with tumors of the skull base and total septal perforation. In the anatomical study, the nasal septum length and the PCF length and area were obtained. In all the specimens, the total reconstruction of the defects was achieved. The radiological study determined that to reconstruct defects secondary to transcribriform, transtuberculum, clival and craniovertebral approaches, the distal incision of the PCF should be placed respectively at -3.7 ± 2.0 cm, -0,2 ± 2,0 cm, +5,5 ± 2,3 cm, +8,4 ± 2.4 cm, from the reference point (external auditory canal). For total repair of the septum, the distal edge of the PCF should be located 0.8 ± 2.0 cm from the reference point. Defects of the skull base (n = 6) and total septal perforation (n = 1) in our clinical cohort were completely reconstructed. This work concludes that the CP presents enough area for the endoscopic reconstruction of the different approaches of the skull base and total septal perforation. The use of the frontal sinus as the entrance and the endoscopic management of the CP in the reconstructions is a feasible and simple technique. Advisors/Committee Members: Universitat de Barcelona. Facultat de Medicina, [email protected] (authoremail), false (authoremailshow), Alobid, Isam (director), Enseñat Nora, Joaquim (director), Alobid, Isam (tutor), true (authorsendemail).

Subjects/Keywords: Cirurgia endoscòpica; Cirugía endoscópica; Endoscopic surgery; Base del crani; Base del cráneo; Skull base; Ciències de la Salut; 617

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santamaría Gadea, A. (2018). Uso endoscópico del colgajo pericraneal para la reconstrucción nasal y de base de cráneo. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/663441

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santamaría Gadea, Alfonso. “Uso endoscópico del colgajo pericraneal para la reconstrucción nasal y de base de cráneo.” 2018. Thesis, Universitat de Barcelona. Accessed April 21, 2021. http://hdl.handle.net/10803/663441.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santamaría Gadea, Alfonso. “Uso endoscópico del colgajo pericraneal para la reconstrucción nasal y de base de cráneo.” 2018. Web. 21 Apr 2021.

Vancouver:

Santamaría Gadea A. Uso endoscópico del colgajo pericraneal para la reconstrucción nasal y de base de cráneo. [Internet] [Thesis]. Universitat de Barcelona; 2018. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10803/663441.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santamaría Gadea A. Uso endoscópico del colgajo pericraneal para la reconstrucción nasal y de base de cráneo. [Thesis]. Universitat de Barcelona; 2018. Available from: http://hdl.handle.net/10803/663441

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

13. Kor, Flip (author). The design of an anthropomorphic head phantom for neurosurgical planning, education and training.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:dc15171c-fa0a-4457-a9a4-ded6e5d3f88b

► Neurosurgery is technically challenging because of the inaccessibility and sensitivity of the brain. The risk of complications for the patient is high and simulation-based training… (more)

▼ Neurosurgery is technically challenging because of the inaccessibility and sensitivity of the brain. The risk of complications for the patient is high and simulation-based training is therefore preferred. However, surgical training in cadavers and virtual reality is not satisfactory. A phantom is a model of organs or tissues consisting of tissue mimicking materials. Anthropomorphic phantoms could solve most of the issues related to VR or cadaveric models and could be used for neurosurgical planning, education and training purposes. For this master thesis, it was chosen to focus on one specific type of surgery, namely endoscopic endonasal neurosurgery. The goal of this study was to find out if an anthropomorphic head phantom could improve endoscopic endonasal neurosurgical planning, education and training. This research project is partly initiated by Philips, as they benefit from a head phantom for two different research projects concerning neuronavigation systems. By reviewing relevant literature and attending an endoscopic endonasal surgery, important anatomy is selected for the design of the head phantom. Also, different phantom characteristics described in literature were reviewed in order to select the correct materials and methods for the production of the head phantom. A head phantom is created from a high-quality CT scan of an anonymous female adult. 3D slicer is used to segment a patient-specific model consisting of three parts, namely the skull, brain and face. In order to segment all structures correctly, a radiologist helped with inspecting the scan. The head phantom is produced in three parts: the skull, the brain and the face. The skull phantom is 3D printed using an Ultimaker 3. It is made of PLA with calcium for the bone parts and MP Flex for the cartilage parts. A mould is 3D printed for the brain phantom using an Ultimaker 2. The brain phantom itself is made of water and coolant with 6 wt% PVA and 1 wt% barium sulphate. The face is 3D printed using an Ultimaker 2 and is made of PLA and MP Flex. The three phantom parts can be fitted together easily and securely. Each part is scanned using an XperCT scan at Philips. By measuring the Hounsfield units, it has been shown that there is significant contrast difference between the skull and the brain phantom. An indention test has shown that the brain phantom does not exactly match the mechanical properties of real brain tissue. The produced skull and the brain phantom have been compared with the original 3D models and the error in size difference between the two scans ranges from 0-1 mm. Neurosurgeons and residents inspected the head phantom, after which they filled in a questionnaire. The questionnaire has been used to evaluate if the anatomical structures are represented correctly and if the head phantom can improve neurosurgical planning, education and training. The anatomic accuracy and appearance of the nasal cavities, sphenoidal sinus, sella turcica and pituitary gland are found realistic by the surgeons. The results of the questionnaire show that… Advisors/Committee Members: Hendriks, Benno (mentor), van den Dobbelsteen, John (graduation committee), Bhattacharya, Nandini (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: Brain; Phantom; Skull base surgery; Neurosurgery; Tissue Mimicking; Surgical training; Surgical procedure; Surgical planning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kor, F. (. (2019). The design of an anthropomorphic head phantom for neurosurgical planning, education and training. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:dc15171c-fa0a-4457-a9a4-ded6e5d3f88b

Chicago Manual of Style (16^th Edition):

Kor, Flip (author). “The design of an anthropomorphic head phantom for neurosurgical planning, education and training.” 2019. Masters Thesis, Delft University of Technology. Accessed April 21, 2021. http://resolver.tudelft.nl/uuid:dc15171c-fa0a-4457-a9a4-ded6e5d3f88b.

MLA Handbook (7^th Edition):

Kor, Flip (author). “The design of an anthropomorphic head phantom for neurosurgical planning, education and training.” 2019. Web. 21 Apr 2021.

Vancouver:

Kor F(. The design of an anthropomorphic head phantom for neurosurgical planning, education and training. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 21]. Available from: http://resolver.tudelft.nl/uuid:dc15171c-fa0a-4457-a9a4-ded6e5d3f88b.

Council of Science Editors:

Kor F(. The design of an anthropomorphic head phantom for neurosurgical planning, education and training. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:dc15171c-fa0a-4457-a9a4-ded6e5d3f88b

Arizona State University

14. Elhadi, Ali M. Surgical Freedom in Endoscopic Skull Base Surgery: Quantitative Analysis for Endoscopic Approaches.

Degree: PhD, Neuroscience, 2014, Arizona State University

URL: http://repository.asu.edu/items/24890

► During the past five decades neurosurgery has made great progress, with marked improvements in patient outcomes. These noticeable improvements of morbidity and mortality can be… (more)

▼ During the past five decades neurosurgery has made great progress, with marked improvements in patient outcomes. These noticeable improvements of morbidity and mortality can be attributed to the advances in innovative technologies used in neurosurgery. Cutting-edge technologies are essential in most neurosurgical procedures, and there is no doubt that neurosurgery has become heavily technology dependent. With the introduction of any new modalities, surgeons must adapt, train, and become thoroughly familiar with the capabilities and the extent of application of these new innovations. Within the past decade, endoscopy has become more widely used in neurosurgery, and this newly adopted technology is being recognized as the new minimally invasive future of neurosurgery. The use of endoscopy has allowed neurosurgeons to overcome common challenges, such as limited illumination and visualization in a very narrow surgical corridor; however, it introduces other challenges, such as instrument "sword fighting" and limited maneuverability (surgical freedom). The newly introduced concept of surgical freedom is very essential in surgical planning and approach selection and can play a role in determining outcome of the procedure, since limited surgical freedom can cause fatigue or limit the extent of lesion resection. In my thesis, we develop a consistent objective methodology to quantify and evaluate surgical freedom, which has been previously evaluated subjectively, and apply this model to the analysis of various endoscopic techniques. This model is crucial for evaluating different endoscopic surgical approaches before they are applied in a clinical setting, for identifying surgical maneuvers that can improve surgical freedom, and for developing endoscopic training simulators that accurately model the surgical freedom of various approaches. Quantifying the extent of endoscopic surgical freedom will also provide developers with valuable data that will help them design improved endoscopes and endoscopic instrumentation.

Subjects/Keywords: Neurosciences; Surgery; Medicine; Angle of attack; Endoscopic; Neuroscience; Neurosurgery; Skull base; Surgical freedom

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Elhadi, A. M. (2014). Surgical Freedom in Endoscopic Skull Base Surgery: Quantitative Analysis for Endoscopic Approaches. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/24890

Chicago Manual of Style (16^th Edition):

Elhadi, Ali M. “Surgical Freedom in Endoscopic Skull Base Surgery: Quantitative Analysis for Endoscopic Approaches.” 2014. Doctoral Dissertation, Arizona State University. Accessed April 21, 2021. http://repository.asu.edu/items/24890.

MLA Handbook (7^th Edition):

Elhadi, Ali M. “Surgical Freedom in Endoscopic Skull Base Surgery: Quantitative Analysis for Endoscopic Approaches.” 2014. Web. 21 Apr 2021.

Vancouver:

Elhadi AM. Surgical Freedom in Endoscopic Skull Base Surgery: Quantitative Analysis for Endoscopic Approaches. [Internet] [Doctoral dissertation]. Arizona State University; 2014. [cited 2021 Apr 21]. Available from: http://repository.asu.edu/items/24890.

Council of Science Editors:

Elhadi AM. Surgical Freedom in Endoscopic Skull Base Surgery: Quantitative Analysis for Endoscopic Approaches. [Doctoral Dissertation]. Arizona State University; 2014. Available from: http://repository.asu.edu/items/24890

15. Jacquesson, Timothée. Tractographie des nerfs crâniens : état de l'art, développement et application en chirurgie des tumeurs de la base du crâne : Cranial nerve tractography : state of the art, development, and application in skull base tumor surgery.

Degree: Docteur es, Sciences, 2018, Lyon

URL: http://www.theses.fr/2018LYSE1309

►

Apparue à la fin des années 1990, la tractographie utilise le signal diffusion de l’imagerie par résonance magnétique (IRM) pour détecter l’orientation préférentielle des molécules… (more)

▼

Apparue à la fin des années 1990, la tractographie utilise le signal diffusion de l’imagerie par résonance magnétique (IRM) pour détecter l’orientation préférentielle des molécules d’eau et reconstruire l’architecture des tissus biologiques, notamment celle des fibres blanches intra cérébrales. Cette technique a suscité l’engouement de la communauté scientifique en permettant, pour la première fois, l’étude in vivo non invasive des structures anatomiques, et en particulier celle du cerveau. Néanmoins, la description de la trajectoire des fibres blanches reste imprécise dans les zones de croisement de fibres et pour les faisceaux de petite taille comme les nerfs crâniens. De multiples méthodes sont développées aux différents étapes d’acquisition et de post-traitement afin d’améliorer la résolution spatiale et angulaire et augmenter la précision de la reconstruction des fibres. En pratique clinique, la détection de la trajectoire des nerfs crâniens déplacés au contact des tumeurs de la base du crâne pourrait apporter une aide significative dans la stratégie chirurgicale et améliorer le résultat fonctionnel pour les patients.Après avoir rappelé les notions fondamentales nécessaires à la compréhension de chaque étape de la tractographie, nous en présentons l’ « état de l’art » dans le cas particulier des nerfs crâniens. A partir de 21 études de la littérature scientifique, nous détaillons tous les paramètres d’acquisition et de tracking, les algorithmes de reconstruction, le design des régions d’intérêt et le filtrage. Puis, nous développons notre propre pipeline de tractographie et montrons son impact sur la prise en charge chirurgicale à travers une série de 62 cas de tumeurs variées de la base du crâne et 2 vignettes cliniques illustratives. Enfin, nous proposons une nouvelle approche, la full-tractography, avec une utilisation potentielle en routine clinique, notamment lors du planning pré-chirurgical

Tractography is a recent imaging tool that used the diffusion signal from the magnetic resonance imaging (MRI) to detect the preferential orientation of water molecules within the tissues and particularly along white fibers of the brain. This technique has caught the attention of the scientific community describing non-invasively the in vivo white matter architecture. Nonetheless, its application to fiber crossing areas or to small-scale structures, such as cranial nerves, remains inaccurate. New methods are being developed for both the acquisition and post-processing steps to provide a higher angular and spatial resolution imaging, and improve the reconstruction of fibers. In the clinical setting, the detection of the trajectory of the cranial nerves displaced by skull base tumors could be a relevant asset for the surgical strategy and the functional outcome. After reminding the basics to understand each step involved in tractography, we present the current state-of-the-art for application to cranial nerves. From 21 selected studies, we report all parameters of acquisition and tracking, algorithms of reconstruction,…

Advisors/Committee Members: Cotton, François (thesis director), Frindel, Carole (thesis director).

Subjects/Keywords: Tractographie; Nerfs crâniens; IRM; Diffusion; Base du crâne; Tumeurs; Tractography; Cranial nerve; MRI; Diffusion; Skull base; Tumors; 570

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jacquesson, T. (2018). Tractographie des nerfs crâniens : état de l'art, développement et application en chirurgie des tumeurs de la base du crâne : Cranial nerve tractography : state of the art, development, and application in skull base tumor surgery. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2018LYSE1309

Chicago Manual of Style (16^th Edition):

Jacquesson, Timothée. “Tractographie des nerfs crâniens : état de l'art, développement et application en chirurgie des tumeurs de la base du crâne : Cranial nerve tractography : state of the art, development, and application in skull base tumor surgery.” 2018. Doctoral Dissertation, Lyon. Accessed April 21, 2021. http://www.theses.fr/2018LYSE1309.

MLA Handbook (7^th Edition):

Jacquesson, Timothée. “Tractographie des nerfs crâniens : état de l'art, développement et application en chirurgie des tumeurs de la base du crâne : Cranial nerve tractography : state of the art, development, and application in skull base tumor surgery.” 2018. Web. 21 Apr 2021.

Vancouver:

Jacquesson T. Tractographie des nerfs crâniens : état de l'art, développement et application en chirurgie des tumeurs de la base du crâne : Cranial nerve tractography : state of the art, development, and application in skull base tumor surgery. [Internet] [Doctoral dissertation]. Lyon; 2018. [cited 2021 Apr 21]. Available from: http://www.theses.fr/2018LYSE1309.

Council of Science Editors:

Jacquesson T. Tractographie des nerfs crâniens : état de l'art, développement et application en chirurgie des tumeurs de la base du crâne : Cranial nerve tractography : state of the art, development, and application in skull base tumor surgery. [Doctoral Dissertation]. Lyon; 2018. Available from: http://www.theses.fr/2018LYSE1309

16. Vicente de Paulo Martins Coêlho Junior. Acesso retrossigmoideo versus petroso posterior: análise comparativa anatomocirúrgica de duas abordagens assistidas por endoscopia à região petroclival.

Degree: 2019, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/17/17137/tde-29102019-114619/

►

A região petroclival abriga peculiaridades anatômicas que acrescem maior complexidade à sua abordagem cirúrgica, representando importante desafio na cirurgia de base do crânio. A conjugação… (more)

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A região petroclival abriga peculiaridades anatômicas que acrescem maior complexidade à sua abordagem cirúrgica, representando importante desafio na cirurgia de base do crânio. A conjugação do endoscópio à microscopia clássica vem se consolidando modernamente, podendo auxiliar sobremaneira neste contexto. Entretanto, havendo diferentes acessos propostos para esta área anatômica, dos quais se destacam o retrossigmoideo e o petroso posterior, a literatura carece de evidências mais robustas para dirimir critérios que orientem a escolha de determinada abordagem, tornando-se importante investigar em qual rota à áreaalvo este dispositivo permite o melhor resultado. Utilizando um modelo cadavérico, nós objetivamos comparar os acessos petroso posterior e o retrossigmoideo, ambos assistidos por endoscopia, quanto à exposição cirúrgica e à manobrabilidade, bem como verificar se o ângulo petroclival e a profundidade clival podem interferir nestas variáveis. Em cinco cabeças de cadáver, um acesso retrossigmoideo foi realizado de um lado e um petroso posterior retrolabiríntico do outro (10 abordagens). Sob visão endoscópica, coordenadas eram adquiridas por neuronavegação para o cálculo das áreas de exposição cirúrgica (petroclival e pontobulbar) e da manobrabilidade, permitindo-se as comparações. Correlações destas variáveis com o ângulo petroclival e a profundidade clival também foram estudadas. Neste modelo, os acessos mostraram equivalência quanto à exposição cirúrgica, mas o retrossigmoideo permitiu significante maior manobrabilidade. O ângulo petroclival e a profundidade clival se correlacionam com a manobrabilidade, mas não com a exposição cirúrgica em ambos os acessos assistidos por endoscopia. As técnicas assistidas por endoscopia permitem adequada exposição petroclival nestes acessos, o que pode dispensar a necessidade de passos cirúrgicos adicionais de maior morbidade. Usando a neuroendoscopia, o acesso retrossigmoideo pode mostrar alguma vantagem sobre o petroso posterior ao lidar com lesões petroclivais cuja consequente distorção anatômica é mínima

The petroclival region bears anatomical peculiarities that add more complexity to its surgical approach, representing an important challenge in skull base surgery. The conjugation of the endoscope to the classic microscopy has been consolidating modernly, being able to help greatly in this context. However, with different accesses proposed for this anatomical area, of which retrosigmoid and posterior petrous stand out, the literature lacks more robust evidence to determine criteria that guide the choice of a particular approach, making it important to investigate which route to the target-area this device allows the best result. Using a cadaveric model, we aimed to compare posterior petrosal and retrosigmoid approaches, both with endoscopic assistance, regarding surgical exposure and maneuverability, as well as to verify whether the petroclival angle and clival depth interfere in these variables. In five cadaveric heads, a retrosigmoid approach was performed on…

Advisors/Committee Members: Benedicto Oscar Colli, José Alberto Landeiro, Francisco Verissimo de Mello Filho, Ricardo Santos de Oliveira.

Subjects/Keywords: Acesso petroso; Acesso retrossigmoideo; Base de crânio; Lesão petroclival; Neuroendoscopia; Neuroendoscopy; Petroclival lesion; Petrosal approach; Retrosigmoid approach; Skull base

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Junior, V. d. P. M. C. (2019). Acesso retrossigmoideo versus petroso posterior: análise comparativa anatomocirúrgica de duas abordagens assistidas por endoscopia à região petroclival. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17137/tde-29102019-114619/

Chicago Manual of Style (16^th Edition):

Junior, Vicente de Paulo Martins Coêlho. “Acesso retrossigmoideo versus petroso posterior: análise comparativa anatomocirúrgica de duas abordagens assistidas por endoscopia à região petroclival.” 2019. Doctoral Dissertation, University of São Paulo. Accessed April 21, 2021. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-29102019-114619/.

MLA Handbook (7^th Edition):

Junior, Vicente de Paulo Martins Coêlho. “Acesso retrossigmoideo versus petroso posterior: análise comparativa anatomocirúrgica de duas abordagens assistidas por endoscopia à região petroclival.” 2019. Web. 21 Apr 2021.

Vancouver:

Junior VdPMC. Acesso retrossigmoideo versus petroso posterior: análise comparativa anatomocirúrgica de duas abordagens assistidas por endoscopia à região petroclival. [Internet] [Doctoral dissertation]. University of São Paulo; 2019. [cited 2021 Apr 21]. Available from: http://www.teses.usp.br/teses/disponiveis/17/17137/tde-29102019-114619/.

Council of Science Editors:

Junior VdPMC. Acesso retrossigmoideo versus petroso posterior: análise comparativa anatomocirúrgica de duas abordagens assistidas por endoscopia à região petroclival. [Doctoral Dissertation]. University of São Paulo; 2019. Available from: http://www.teses.usp.br/teses/disponiveis/17/17137/tde-29102019-114619/

17. Henrique Candeu Patrício. Estudo das relações da artéria frontobasilar medial com a base anterior do crânio através de angiotomografia computadorizada.

Degree: 2017, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09112017-112056/

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A introdução dos endoscópios na otorrinolaringologia determinou um grande avanço tecnológico, permitindo a sistematização da cirurgia endoscópica nasossinusal funcional. A possibilidade de trabalhar nos limites… (more)

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A introdução dos endoscópios na otorrinolaringologia determinou um grande avanço tecnológico, permitindo a sistematização da cirurgia endoscópica nasossinusal funcional. A possibilidade de trabalhar nos limites das cavidades nasossinusais com boa iluminação e visibilidade permitiu a expansão dessa cirurgia para abordar lesões da base do crânio e no interior da cavidade craniana, ampliando consideravelmente as suas indicações e a gravidade das suas complicações. Dentre estas complicações as lesões vasculares e ou de nervos cranianos estão entre as principais causas de morbidade. A artéria frontobasilar medial (AFM) é o primeiro ramo cortical do segmento pós-comunicante da artéria cerebral anterior e possui percurso próximo a base anterior do crânio. Havendo penetração intracraniana através da base anterior do crânio, durante uma cirurgia endoscópica endonasal, a AFM pode ser lesionada causando graves complicações. O objetivo deste estudo foi analisar as relações da AFM com a base anterior do crânio e reparos anatômicos utilizados em cirurgia endonasal, através de imagens obtidas por angiotomografia de crânio. E também identificar os locais de maior proximidade da AFM com a base anterior do crânio, sugerindo áreas de maior risco de lesão em cirurgia endonasal. Foram analisados 52 exames de angiotomografia de crânio, realizados no período de 2013 a 2015. O software OsiriXÒ foi utilizado para fazer as medições entre a AFM e os pontos de referência nos planos sagital e coronal, na ordem cronológica em que os exames foram coletados. A AFM descreveu um trajeto descendente, próximo a linha média (distancia média de 1,5 mm), se aproximando do plano esfenoidal (distancia média de 1,8 mm) e depois um trajeto ascendente à medida que se dirige para porção anterior do crânio, com distância média de 4,4mm na região da parede anterior do seio esfenoidal e de 12mm na região onde se encontra a artéria etmoidal anterior. Considerando o ângulo de trabalho na cirurgia endonasal e a os locais de maior proximidade da AFM com a base anterior do crânio, as regiões do etmoide posterior e plano esfenoidal foram as áreas de maior risco de sua lesão Study of the relations between medial orbitofrontal artery and anterior skull base performed by computed tomography angiography

The introduction of endoscopes in otolaryngology determined a great technological advance, allowing the systematization of the endoscopic endonasal sinus surgery. The possibility of working at the nasal cavity boundaries with good illumination and visibility allowed the expansion of this surgery to address lesions of the skull base and inside the cranial cavity, considerably broadening its indications and the severity of its complications. Among these complications, vascular lesions and cranial nerves are among the main causes of morbidity. The medial orbitofrontal artery (MOFA) the first cortical branch of the post-communicating segment of the anterior cerebral artery and has a path near the anterior skull base. If there is an intracranial penetration through the…

Advisors/Committee Members: Luiz Ubirajara Sennes, Fabio de Rezende Pinna, Fabrizio Ricci Romano, Rodrigo de Paula Santos, Fabrício Scapini.

Subjects/Keywords: Anatomia; Artéria cerebral anterior; Base do crânio; Complicações intraoperatórias; Endoscopia; Radiologia; Anatomy; Anterior cerebral artery; Endoscopy, Intraoperative complications; Radiology; Skull base

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patrício, H. C. (2017). Estudo das relações da artéria frontobasilar medial com a base anterior do crânio através de angiotomografia computadorizada. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09112017-112056/

Chicago Manual of Style (16^th Edition):

Patrício, Henrique Candeu. “Estudo das relações da artéria frontobasilar medial com a base anterior do crânio através de angiotomografia computadorizada.” 2017. Doctoral Dissertation, University of São Paulo. Accessed April 21, 2021. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09112017-112056/.

MLA Handbook (7^th Edition):

Patrício, Henrique Candeu. “Estudo das relações da artéria frontobasilar medial com a base anterior do crânio através de angiotomografia computadorizada.” 2017. Web. 21 Apr 2021.

Vancouver:

Patrício HC. Estudo das relações da artéria frontobasilar medial com a base anterior do crânio através de angiotomografia computadorizada. [Internet] [Doctoral dissertation]. University of São Paulo; 2017. [cited 2021 Apr 21]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09112017-112056/.

Council of Science Editors:

Patrício HC. Estudo das relações da artéria frontobasilar medial com a base anterior do crânio através de angiotomografia computadorizada. [Doctoral Dissertation]. University of São Paulo; 2017. Available from: http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09112017-112056/

University of Melbourne

18. Dixon, Benjamin J. Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/123744

► Modern diagnostic imaging techniques allow surgeons to preoperatively scrutinise anatomy and pathology in an ever more precise fashion. Surgical planning may be honed to minimise… (more)

▼ Modern diagnostic imaging techniques allow surgeons to preoperatively scrutinise anatomy and pathology in an ever more precise fashion. Surgical planning may be honed to minimise access and perform targeted yet thorough procedures. Image guided surgery systems help integrate this valuable data into the operating theatre to aid spatial awareness during surgery. Advanced navigational displays show promise in providing surgeons with real-time image guidance presented in an intuitive manner during a procedure. In addition to standard 2-dimensional cross-sectional views, options for visual presentation include 3-dimensional virtual views and augmented reality. Live computer-assisted feedback may include a 3-dimensional visual representation of tool position and critical structure’s with proximity auditory alerts. Although orientation may be enhanced, additional stimuli inherently demand some attention from the operator. An ideal user interface would provide accurate and accessible navigational data with minimal distraction. This thesis explores, through pre-clinical navigation and dissection trials, ways to provide the potential benefits of surgical precision and efficiency while mitigating distracting cues. Cadaver dissection trials allowed structured testing of the new technology, which is directly compared to conventional systems. Real-time surgical navigation systems are shown to enhance spatial awareness while reducing task workload during complex endoscopic skull base surgery. These systems showed particular promise where there was high spatial demand, compromised visual landmarks and proximity to critical structures. World first surgical studies investigating the attentional cost of advanced navigational displays highlight the potential dangers of this technology. The concept of inattentional blindness is introduced into the surgical literature with experimental evidence of its existence. Augmented reality advanced navigational displays are shown to increase inattentional blindness with a reduced detection of unexpected but salient findings. The findings serve to caution injudicious adoption of this technology and reinforce the need for pre-clinical human factors testing.

Subjects/Keywords: surgery; surgical navigation; image guided surgery; augmented reality; inattentional blindness; virtual reality; skull base surgery; computer assisted surgery

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dixon, B. J. (2017). Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/123744

Chicago Manual of Style (16^th Edition):

Dixon, Benjamin J. “Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction.” 2017. Doctoral Dissertation, University of Melbourne. Accessed April 21, 2021. http://hdl.handle.net/11343/123744.

MLA Handbook (7^th Edition):

Dixon, Benjamin J. “Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction.” 2017. Web. 21 Apr 2021.

Vancouver:

Dixon BJ. Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/11343/123744.

Council of Science Editors:

Dixon BJ. Optimising real-time surgical navigation interface design: enhancing spatial awareness while limiting distraction. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/123744

University of New South Wales

19. Aplin, Kenneth Peter. Basicranial regions of diprotodontian marsupials: anatomy, ontogeny and phylogeny.

Degree: Biological, Earth & Environmental Sciences, 1990, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55805 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:39403/SOURCE01?view=true

Subjects/Keywords: Skull base; Diprotodontidae; Marsupials; Thesis Digitisation Program

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aplin, K. P. (1990). Basicranial regions of diprotodontian marsupials: anatomy, ontogeny and phylogeny. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55805 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:39403/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Aplin, Kenneth Peter. “Basicranial regions of diprotodontian marsupials: anatomy, ontogeny and phylogeny.” 1990. Doctoral Dissertation, University of New South Wales. Accessed April 21, 2021. http://handle.unsw.edu.au/1959.4/55805 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:39403/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Aplin, Kenneth Peter. “Basicranial regions of diprotodontian marsupials: anatomy, ontogeny and phylogeny.” 1990. Web. 21 Apr 2021.

Vancouver:

Aplin KP. Basicranial regions of diprotodontian marsupials: anatomy, ontogeny and phylogeny. [Internet] [Doctoral dissertation]. University of New South Wales; 1990. [cited 2021 Apr 21]. Available from: http://handle.unsw.edu.au/1959.4/55805 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:39403/SOURCE01?view=true.

Council of Science Editors:

Aplin KP. Basicranial regions of diprotodontian marsupials: anatomy, ontogeny and phylogeny. [Doctoral Dissertation]. University of New South Wales; 1990. Available from: http://handle.unsw.edu.au/1959.4/55805 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:39403/SOURCE01?view=true

Universidade Nova

20. Almeida, Gonçalo Maria Morão Neto de. Contribuição da Unidade Funcional de Otoneurocirurgia e Neurorrinologia do Hospital de Egas Moniz para o tratamento da patologia da base do crânio.

Degree: 2018, Universidade Nova

URL: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/27851

► RESUMO: A multidisciplinaridade das equipas cirúrgicas de Neurocirurgia e de Otorrinolaringologia, envolvidas no tratamento da patologia da base do crânio, tem-se revelado fundamental para a… (more)

▼ RESUMO: A multidisciplinaridade das equipas cirúrgicas de Neurocirurgia e de Otorrinolaringologia, envolvidas no tratamento da patologia da base do crânio, tem-se revelado fundamental para a progressão dos conhecimentos científicos e para a melhoria da qualidade de vida (QOL) dos doentes em todas as suas vertentes. A subespecialização nesta área é, atualmente, uma realidade em inúmeros centros cirúrgicos, nos quais a formação pós-graduada constitui um aspeto fundamental. A equipa de Otoneurocirurgia do Hospital de Egas Moniz, em Lisboa, tem contribuído, desde o final da década de oitenta, para o tratamento de toda a patologia da base do crânio, com um particular relevo para as patologias compartilhadas pelas duas especialidades. A lesão do nervo facial na cirurgia do ângulo ponto-cerebeloso (APC) tem sido difícil de ultrapassar nas últimas décadas. Com o trabalho publicado em 2006 pelo Professor Toshiaki Taoka sobre a utilidade da Tratografia do Nervo Facial (Diffusion Tensor Tractography) na identificação do trajeto do nervo facial, na cisterna do ângulo ponto-cerebeloso, e sua respetiva aplicação na cirurgia dos tumores desta área anatómica, era necessário iniciar uma série de estudos que permitissem determinar o seu eventual contributo na cirurgia dos tumores do APC. A programação deste estudo teve início em 2009, em Roterdão, na Holanda, contando com o envolvimento de uma vasta equipa constituída por Neurocirurgiões, Otorrinolaringologistas, Radiologistas e Neurorradiologistas. Englobou ainda três hospitais: o Hospital de Egas Moniz (HEM), o Hospital Lusíadas Lisboa (HLL), ambos em Lisboa, e o Nara Medical University Hospital (NMUH), no Japão. Até 2011, a equipa desenvolveu vários protocolos de estudo no sentido de melhorar a técnica de imagem para os tumores benignos localizados no ângulo ponto-cerebeloso. Foi iniciado um estudo com um desenho quase-experimental, que decorreu de fevereiro de 2011 a maio de 2015, e durante o qual se desenvolveu e aperfeiçoou uma técnica de imagem inédita em Portugal, com recurso à Ressonância Magnética, a Tratografia do Nervo Facial (Diffusion Tensor Tractography), aplicada à cirurgia dos tumores benignos do ângulo ponto-cerebeloso. Com a finalidade de aferir o contributo de uma equipa de Otoneurocirurgia no tratamento da patologia da base do crânio, propusemos avaliar o impacto da Tratografia do Nervo Facial na cirurgia dos tumores do ângulo ponto-cerebeloso através de três objetivos específicos. O primeiro consistia em medir a influência da Tratografia pré-operatória do nervo facial na morbilidade cirúrgica, com especial ênfase nos Schwannomas Vestibulares. O segundo objetivo era o de classificar o impacto da Tratografia sobre o tempo cirúrgico. Já o terceiro propósito do estudo envolvia a ponderação do efeito da Tratografia nos custos das cirurgias realizadas, com recurso a esta técnica. Foram utilizados dois grupos de pacientes: um grupo de controlo, constituído por 42 participantes submetidos a uma cirurgia aos Schwannomas Vestibulares localizados no ângulo ponto-cerebeloso… Advisors/Committee Members: Escada, Pedro Alberto Batista Brissos de Sousa, O’Neill, João Erse Goyri, Aguiar, Pedro Manuel Vargas.

Subjects/Keywords: Ângulo ponto-cerebeloso; Cirurgia da base do crânio; Otoneurocirurgia; Schwannomas vestibulares; Tratografia do nervo facial; Cerebellopontine angle; Skull base surgery; Oto-neurosurger; Vestibular schwannomas; Facial nerve tractography; Ciências Médicas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Almeida, G. M. M. N. d. (2018). Contribuição da Unidade Funcional de Otoneurocirurgia e Neurorrinologia do Hospital de Egas Moniz para o tratamento da patologia da base do crânio. (Thesis). Universidade Nova. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/27851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Almeida, Gonçalo Maria Morão Neto de. “Contribuição da Unidade Funcional de Otoneurocirurgia e Neurorrinologia do Hospital de Egas Moniz para o tratamento da patologia da base do crânio.” 2018. Thesis, Universidade Nova. Accessed April 21, 2021. https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/27851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Almeida, Gonçalo Maria Morão Neto de. “Contribuição da Unidade Funcional de Otoneurocirurgia e Neurorrinologia do Hospital de Egas Moniz para o tratamento da patologia da base do crânio.” 2018. Web. 21 Apr 2021.

Vancouver:

Almeida GMMNd. Contribuição da Unidade Funcional de Otoneurocirurgia e Neurorrinologia do Hospital de Egas Moniz para o tratamento da patologia da base do crânio. [Internet] [Thesis]. Universidade Nova; 2018. [cited 2021 Apr 21]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/27851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Almeida GMMNd. Contribuição da Unidade Funcional de Otoneurocirurgia e Neurorrinologia do Hospital de Egas Moniz para o tratamento da patologia da base do crânio. [Thesis]. Universidade Nova; 2018. Available from: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/27851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Salamanca

21. Menocal Funez, Nelson Dagoberto. Avances en la visualización de elementos vásculo nerviosos de la base del cráneo mediante técnicas de neuroimagen de última generación .

Degree: 2012, Universidad de Salamanca

URL: http://hdl.handle.net/10366/115619

► [ES] La presente tesis tiene por objetivo el estudio detallado de la morfología de la base del cráneo y los elementos vásculo‐nerviosos que la cruzan,… (more)

Subjects/Keywords: Tesis y disertaciones académicas; Universidad de Salamanca (España); Academic dissertations; Neurociencias; Craneo - Base; Anatomía humana; Diagnóstico por imagen; Skull base; Human anatomy; Diagnostic imaging; Neurosciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Menocal Funez, N. D. (2012). Avances en la visualización de elementos vásculo nerviosos de la base del cráneo mediante técnicas de neuroimagen de última generación . (Thesis). Universidad de Salamanca. Retrieved from http://hdl.handle.net/10366/115619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Menocal Funez, Nelson Dagoberto. “Avances en la visualización de elementos vásculo nerviosos de la base del cráneo mediante técnicas de neuroimagen de última generación .” 2012. Thesis, Universidad de Salamanca. Accessed April 21, 2021. http://hdl.handle.net/10366/115619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Menocal Funez, Nelson Dagoberto. “Avances en la visualización de elementos vásculo nerviosos de la base del cráneo mediante técnicas de neuroimagen de última generación .” 2012. Web. 21 Apr 2021.

Vancouver:

Menocal Funez ND. Avances en la visualización de elementos vásculo nerviosos de la base del cráneo mediante técnicas de neuroimagen de última generación . [Internet] [Thesis]. Universidad de Salamanca; 2012. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10366/115619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Menocal Funez ND. Avances en la visualización de elementos vásculo nerviosos de la base del cráneo mediante técnicas de neuroimagen de última generación . [Thesis]. Universidad de Salamanca; 2012. Available from: http://hdl.handle.net/10366/115619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Ana Paula da Cunha Barbosa de Lima. Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular.

Degree: 2017, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-05062018-080742/

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Objetivo: O objetivo deste trabalho foi verificar a existência de variações da morfometria de base de crânio entre indivíduos com fissura labiopalatal, com deformidade dentofacial… (more)

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Objetivo: O objetivo deste trabalho foi verificar a existência de variações da morfometria de base de crânio entre indivíduos com fissura labiopalatal, com deformidade dentofacial e sem deformidade dentofacial, grupo controle. Metodologia: Três grupos de indivíduos, um grupo com deformidade dentofacial sem associação com fissura labiopalatal (DFSF), outro com fissura labiopalatal (FS), e outro grupo de pacientes sem fissura e sem deformidade (CTRL - Controle), foram elencados por meio de registros de prontuários e de imagens em DICOM (Digital Imaging Communications in Medicine) de suas tomografias computadorizadas. Por meio da identificação dos pontos cefalométricos basio (Ba), sela (S) e nasio (N), no software Dolphin Imaging 11.9, obteve-se a distância entre os pontos Ba-S (DBaS), S-N (DSN) bem como o ângulo formado entre os pontos Ba-S-N (AnGBaSN). As variáveis cefalométricas em questão foram avaliadas considerando (p<0,05). Resultados: Vinte indivíduos compuseram cada um dos grupos. Verificamos que a distância S-N (DSN) não apresentou diferença estatística entre os grupos, mas a distância Ba-S (DBaS) e o ângulo Ba-S-N (AnGBaSN) apresentaram diferenças estatísticas quando comparados os três grupos. O ângulo Ba-S-N (AnGBaSN) não apresentou diferença estatística quando comparados o grupo controle (CTRL) e o grupo de pacientes portadores de fissura labiopalatal (FS), mas apresentou diferença estatística em relação ao do grupo de pacientes com deformidades faciais sem fissuras labiopalatais (DFSF). A distância BaS (DBaS) apresentou diferença estatística entre o grupo de pacientes portadores de fissuras (FS) em relação aos outros dois grupos. Conclusão: Diferenças na morfometria da base de crânio entre indivíduos com deformidade dentofacial associada ou não a fissuras labiopalatais sugerem que valores padronizados para análises cefalométricas que envolvam tais estruturas sejam usadas com cautela. Novos padrões cefalométricos, em especial por análise 3D, são desejáveis para compensação dessas diferenças anatômicas.

Objective: The aim of this study was to verify the existence of variations of the skull base morphometry between patients with cleft lip and palate, with dentofacial deformity group and without dentofacial deformity (control group). Methodology: Three groups of patients, one group with dentofacial deformity associated without cleft lip and palate (DFSF), another with cleft lip and palate (FS), and another group of patients without cleft and without deformity (CTRL) were included by means of medical records and DICOM (Digital Imaging Communications in Medicine) images of their CT (Computed Tomography) scans. By identifying the basio (Ba), sela (S) and nasio (N) cephalometric points in the Dolphin Imaging 11.9 software, the distance between the points Ba-S (DBaS), S-N(DSN) and the angle formed between points Ba-S-N (AnGBaSN) were the variables. They were statistically evaluated by means of the p> 0.05. Results: Twenty patients were included on each group. We found that the distance S-N (DSN) is not…

Advisors/Committee Members: Maria da Graça Naclerio Homem, Alexandre Meireles Borba, Maria Cristina Zindel Deboni, Fernando Melhem Elias.

Subjects/Keywords: Base do crânio; Fissura Labiopalatal; Morfologia; Morfometria; Tomografia Computadorizada feixe cônico; Base of the skull; Basicranium; Cleft lip and palate; Cone-bean computed tomography; Morphology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lima, A. P. d. C. B. d. (2017). Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23149/tde-05062018-080742/

Chicago Manual of Style (16^th Edition):

Lima, Ana Paula da Cunha Barbosa de. “Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular.” 2017. Doctoral Dissertation, University of São Paulo. Accessed April 21, 2021. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-05062018-080742/.

MLA Handbook (7^th Edition):

Lima, Ana Paula da Cunha Barbosa de. “Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular.” 2017. Web. 21 Apr 2021.

Vancouver:

Lima APdCBd. Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular. [Internet] [Doctoral dissertation]. University of São Paulo; 2017. [cited 2021 Apr 21]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-05062018-080742/.

Council of Science Editors:

Lima APdCBd. Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular. [Doctoral Dissertation]. University of São Paulo; 2017. Available from: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-05062018-080742/

23. Carlos Diógenes Pinheiro Neto. Estudo do retalho nasosseptal para reconstrução endoscópica da base do crânio anterior.

Degree: 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5143/tde-30112011-174005/

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Introdução: O uso do retalho nasosseptal (NS) para a reconstrução endoscópica da base do crânio foi fator fundamental para o avanço dos acessos endonasais expandidos.… (more)

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Introdução: O uso do retalho nasosseptal (NS) para a reconstrução endoscópica da base do crânio foi fator fundamental para o avanço dos acessos endonasais expandidos. Objetivos: Aferir as dimensões do retalho NS e do defeito da base do crânio anterior (BCA) após ressecção craniofacial endoscópica e verificar a suficiência do retalho para cobrir o defeito. Estudar a anatomia da artéria septal (AS) e sua relação com o óstio do seio esfenoide. Métodos: Estudo anatômico do retalho NS em 14 cadáveres. Após ressecção craniofacial endoscópica, foi verificado a suficiência do retalho em cobrir o defeito na BCA. A AS foi dissecada e estuda quanto ao número de ramos presentes no pedículo e sua distância em relação ao óstio do seio esfenoide. Estudo radiológico com tomografia computadorizada de 30 pacientes para a comparação entre medidas do retalho NS e as do defeito na BCA. Resultados: O retalho foi suficiente para cobrir o defeito na BCA nas 14 dissecções. Em 71,4% dos casos, dois ramos da AS foram encontrados no pedículo. A distância média entre o primeiro ou único ramo ao óstio do esfenoide foi de 9,3mm. No estudo radiológico, a média da área reconstrutora do retalho (17,12cm2) foi constantemente maior que a média da área do defeito (8,64cm2) (p<0,001). A diferença entre o comprimento superior do retalho e a distância anteroposterior do defeito foi menor ou igual a 5mm em 26,7% dos casos. A comparação entre a largura anterior do retalho e a distância interorbitária anterior revelou que em 33% dos casos a diferença foi 5mm. A incorporação da mucosa do assoalho da fossa nasal ao retalho aumentou essa diferença em mais 10mm em todos os casos. Conclusões: As dimensões do retalho NS são suficientes para cobrir o defeito na BCA. A extremidade anterior do comprimento anteroposterior do defeito apresenta maior risco de falha de cobertura. A incorporação da mucosa do assoalho da fossa nasal ao retalho é importante para diminuir o risco de falha de cobertura anterior na largura do defeito. Em geral, é mais comum a presença de dois ramos da AS no pedículo

Introduction: Use of the nasoseptal (NS) flap for endoscopic skull base reconstruction was an essential contribution for the evolution of the expanded endonasal approaches. Objectives: Measure the dimensions of the NS flap and the anterior skull base (ASB) defect after endoscopic craniofacial resection and verify if the flap is sufficient to cover the defect. Study the anatomy of the septal artery (SA) and its relation with the sphenoid ostium. Methods: Anatomical study of the NS flap in 14 cadavers. After endoscopic craniofacial resection, the sufficiency of the flap to cover the ASB defect was assessed. The SA was dissected and studied regarding the number of branches in the pedicle and the distance between the artery and the sphenoid ostium. Radiological study using CT scans of 30 patients for comparison among measurements of the NS flap and the ASB defect. Results: The flap was sufficient to cover the ASB in all 14 dissections. In 71.4% of the cases, 2 branches of the…

Advisors/Committee Members: Luiz Ubirajara Sennes, Rubens Vuono de Brito Neto, Marcus Miranda Lessa, Renato Roithmann, Fabrizio Ricci Romano.

Subjects/Keywords: Anatomia; Base do crânio; Endoscopia; Radiologia; Reconstrução; Anatomy; Endoscopy; Radiology; Reconstruction; Skull base

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Neto, C. D. P. (2011). Estudo do retalho nasosseptal para reconstrução endoscópica da base do crânio anterior. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5143/tde-30112011-174005/

Chicago Manual of Style (16^th Edition):

Neto, Carlos Diógenes Pinheiro. “Estudo do retalho nasosseptal para reconstrução endoscópica da base do crânio anterior.” 2011. Doctoral Dissertation, University of São Paulo. Accessed April 21, 2021. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-30112011-174005/.

MLA Handbook (7^th Edition):

Neto, Carlos Diógenes Pinheiro. “Estudo do retalho nasosseptal para reconstrução endoscópica da base do crânio anterior.” 2011. Web. 21 Apr 2021.

Vancouver:

Neto CDP. Estudo do retalho nasosseptal para reconstrução endoscópica da base do crânio anterior. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Apr 21]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5143/tde-30112011-174005/.

Council of Science Editors:

Neto CDP. Estudo do retalho nasosseptal para reconstrução endoscópica da base do crânio anterior. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/5/5143/tde-30112011-174005/

University of Florida

24. Stubblefield, Phoebe Regina. Cranial size in relation to body mass and skeletal robusticity in modern humans.

Degree: PhD, Anthropology, 2002, University of Florida

URL: https://ufdc.ufl.edu/AA00031565

Subjects/Keywords: Autopsies; Body size; Body weight; Clavicle; Correlation coefficients; Humans; Mathematical variables; Skull; Skull base; Waves

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stubblefield, P. R. (2002). Cranial size in relation to body mass and skeletal robusticity in modern humans. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00031565

Chicago Manual of Style (16^th Edition):

Stubblefield, Phoebe Regina. “Cranial size in relation to body mass and skeletal robusticity in modern humans.” 2002. Doctoral Dissertation, University of Florida. Accessed April 21, 2021. https://ufdc.ufl.edu/AA00031565.

MLA Handbook (7^th Edition):

Stubblefield, Phoebe Regina. “Cranial size in relation to body mass and skeletal robusticity in modern humans.” 2002. Web. 21 Apr 2021.

Vancouver:

Stubblefield PR. Cranial size in relation to body mass and skeletal robusticity in modern humans. [Internet] [Doctoral dissertation]. University of Florida; 2002. [cited 2021 Apr 21]. Available from: https://ufdc.ufl.edu/AA00031565.

Council of Science Editors:

Stubblefield PR. Cranial size in relation to body mass and skeletal robusticity in modern humans. [Doctoral Dissertation]. University of Florida; 2002. Available from: https://ufdc.ufl.edu/AA00031565

25. 富田, 隆浩. New dried human amniotic membrane is useful as a substitute for dural repair after skull base surgery : 頭蓋底手術における硬膜修復素材としてのヒト乾燥羊膜の有用性.

Degree: 博士（医学）, 2016, University of Toyama / 富山大学

URL: http://hdl.handle.net/10110/12990 ; http://dx.doi.org/10.15099/00005079

富山大学・富医薬博乙第47号・富田隆浩・2014/02/27

Subjects/Keywords: Amniotic membrane; Cerebrospinal fluid (CFS) leakage; Dural repair; Dural substitute; Skull base surgery

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

富田, �. (2016). New dried human amniotic membrane is useful as a substitute for dural repair after skull base surgery : 頭蓋底手術における硬膜修復素材としてのヒト乾燥羊膜の有用性. (Thesis). University of Toyama / 富山大学. Retrieved from http://hdl.handle.net/10110/12990 ; http://dx.doi.org/10.15099/00005079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

富田, 隆浩. “New dried human amniotic membrane is useful as a substitute for dural repair after skull base surgery : 頭蓋底手術における硬膜修復素材としてのヒト乾燥羊膜の有用性.” 2016. Thesis, University of Toyama / 富山大学. Accessed April 21, 2021. http://hdl.handle.net/10110/12990 ; http://dx.doi.org/10.15099/00005079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

富田, 隆浩. “New dried human amniotic membrane is useful as a substitute for dural repair after skull base surgery : 頭蓋底手術における硬膜修復素材としてのヒト乾燥羊膜の有用性.” 2016. Web. 21 Apr 2021.

Vancouver:

富田 �. New dried human amniotic membrane is useful as a substitute for dural repair after skull base surgery : 頭蓋底手術における硬膜修復素材としてのヒト乾燥羊膜の有用性. [Internet] [Thesis]. University of Toyama / 富山大学; 2016. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10110/12990 ; http://dx.doi.org/10.15099/00005079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

富田 �. New dried human amniotic membrane is useful as a substitute for dural repair after skull base surgery : 頭蓋底手術における硬膜修復素材としてのヒト乾燥羊膜の有用性. [Thesis]. University of Toyama / 富山大学; 2016. Available from: http://hdl.handle.net/10110/12990 ; http://dx.doi.org/10.15099/00005079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Voormolen, E.H.J. Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging.

Degree: 2018, University Utrecht

URL: http://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; http://dspace.library.uu.nl/handle/1874/364927

► Before the 1970s, a skull base tumor implied for the majority of patients a poor prognosis, leading to severe functional impairment and probable death, either… (more)

▼ Before the 1970s, a skull base tumor implied for the majority of patients a poor prognosis, leading to severe functional impairment and probable death, either from natural progression or surgical efforts. Today, patients treated for lateral skull base tumors have near normal life expectancies in the majority of cases. However, preventing iatrogenic morbidity (e.g. cranial nerve palsy) due to surgery, remains a crucial issue. It is the primary concern of this thesis. Its chief hypothesis is that application of computer assistance during skull base surgery reduces iatrogenic morbidity. Accordingly, the overall aim of this thesis is to improve the standard of care of patients with lateral skull base tumors by advancing the field of Computer Assisted Surgery of the Skull Base (CASSB). Specifically, this thesis presents scientific contributions to preoperative imaging and intraoperative image guidance. In terms of developments in preoperative imaging, it describes the development and evaluation of a novel segmentation algorithm (NerveClick) for semi-automatic segmentation of the intra-temporal facial nerve centerline from high resolution CT images. NerveClick’s is specially developed to be used for image guidance during lateral skull base surgery. Surgeons using NerveClick could segment facial nerve centerlines fast and with high accuracy. Furthermore, the use of ultra-high field (7T) MR images for image guidance was evaluated. 7T MRI is a promising imaging technology capable of increasing resolution and contrast. For instance, it can be used to improve skull base surgery by enhanced localization of important blood vessels of skull base tumors. We conclude that 7T MR images can be used for CASSB with the following work-around: the patient-to-image registration should be performed on a routine (CT or MR) image, which is subsequently co-registered to the 7T MR image on the image guidance machine. Concerning advancements in image guidance, this thesis describes methods to offer active real-time intraoperative feedback to the surgeon. It describes the development and validation of new software, called EVADE, which is an acronym for exposure visualization and audible distance emission. It is specifically designed for active image guidance during drilling of the (lateral) skull base. EVADE updates the prior image and visualizes the bone drilling process during skull base surgery virtually in (near) real-time, without need for intra-operative imaging. This functionality is also known as ‘virtual drilling’. Furthermore, the software continuously calculates the distance from the drill tip to segmented normal anatomical structures (e.g. the facial nerve) and produces audiovisual warnings if the surgeon drills in too close vicinity. This feature is called ‘distance control’. We found that virtual drilling is accurate. Moreover, we conclude that distance control protects normal anatomical structures from iatrogenic damage during drilling of the skull base, at least in an experimental setting. Therefore, we conclude that EVADE has… Advisors/Committee Members: Robe, PAJT, Viergever, Max A., Berkelbach vd Sprenkel, JW, Noordmans, Herke Jan.

Subjects/Keywords: neurosurgery; image guidance; skull base; 7 Tesla magnetic resonance imaging

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Voormolen, E. H. J. (2018). Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging. (Doctoral Dissertation). University Utrecht. Retrieved from http://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; http://dspace.library.uu.nl/handle/1874/364927

Chicago Manual of Style (16^th Edition):

Voormolen, E H J. “Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging.” 2018. Doctoral Dissertation, University Utrecht. Accessed April 21, 2021. http://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; http://dspace.library.uu.nl/handle/1874/364927.

MLA Handbook (7^th Edition):

Voormolen, E H J. “Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging.” 2018. Web. 21 Apr 2021.

Vancouver:

Voormolen EHJ. Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging. [Internet] [Doctoral dissertation]. University Utrecht; 2018. [cited 2021 Apr 21]. Available from: http://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; http://dspace.library.uu.nl/handle/1874/364927.

Council of Science Editors:

Voormolen EHJ. Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging. [Doctoral Dissertation]. University Utrecht; 2018. Available from: http://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; http://dspace.library.uu.nl/handle/1874/364927

27. Voormolen, E.H.J. Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging.

Degree: 2018, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; https://dspace.library.uu.nl/handle/1874/364927

► Before the 1970s, a skull base tumor implied for the majority of patients a poor prognosis, leading to severe functional impairment and probable death, either… (more)

▼ Before the 1970s, a skull base tumor implied for the majority of patients a poor prognosis, leading to severe functional impairment and probable death, either from natural progression or surgical efforts. Today, patients treated for lateral skull base tumors have near normal life expectancies in the majority of cases. However, preventing iatrogenic morbidity (e.g. cranial nerve palsy) due to surgery, remains a crucial issue. It is the primary concern of this thesis. Its chief hypothesis is that application of computer assistance during skull base surgery reduces iatrogenic morbidity. Accordingly, the overall aim of this thesis is to improve the standard of care of patients with lateral skull base tumors by advancing the field of Computer Assisted Surgery of the Skull Base (CASSB). Specifically, this thesis presents scientific contributions to preoperative imaging and intraoperative image guidance. In terms of developments in preoperative imaging, it describes the development and evaluation of a novel segmentation algorithm (NerveClick) for semi-automatic segmentation of the intra-temporal facial nerve centerline from high resolution CT images. NerveClick’s is specially developed to be used for image guidance during lateral skull base surgery. Surgeons using NerveClick could segment facial nerve centerlines fast and with high accuracy. Furthermore, the use of ultra-high field (7T) MR images for image guidance was evaluated. 7T MRI is a promising imaging technology capable of increasing resolution and contrast. For instance, it can be used to improve skull base surgery by enhanced localization of important blood vessels of skull base tumors. We conclude that 7T MR images can be used for CASSB with the following work-around: the patient-to-image registration should be performed on a routine (CT or MR) image, which is subsequently co-registered to the 7T MR image on the image guidance machine. Concerning advancements in image guidance, this thesis describes methods to offer active real-time intraoperative feedback to the surgeon. It describes the development and validation of new software, called EVADE, which is an acronym for exposure visualization and audible distance emission. It is specifically designed for active image guidance during drilling of the (lateral) skull base. EVADE updates the prior image and visualizes the bone drilling process during skull base surgery virtually in (near) real-time, without need for intra-operative imaging. This functionality is also known as ‘virtual drilling’. Furthermore, the software continuously calculates the distance from the drill tip to segmented normal anatomical structures (e.g. the facial nerve) and produces audiovisual warnings if the surgeon drills in too close vicinity. This feature is called ‘distance control’. We found that virtual drilling is accurate. Moreover, we conclude that distance control protects normal anatomical structures from iatrogenic damage during drilling of the skull base, at least in an experimental setting. Therefore, we conclude that EVADE has… Advisors/Committee Members: Robe, PAJT, Viergever, Max A., Berkelbach vd Sprenkel, JW, Noordmans, Herke Jan.

Subjects/Keywords: neurosurgery; image guidance; skull base; 7 Tesla magnetic resonance imaging

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Voormolen, E. H. J. (2018). Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; https://dspace.library.uu.nl/handle/1874/364927

Chicago Manual of Style (16^th Edition):

Voormolen, E H J. “Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging.” 2018. Doctoral Dissertation, University Utrecht. Accessed April 21, 2021. https://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; https://dspace.library.uu.nl/handle/1874/364927.

MLA Handbook (7^th Edition):

Voormolen, E H J. “Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging.” 2018. Web. 21 Apr 2021.

Vancouver:

Voormolen EHJ. Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging. [Internet] [Doctoral dissertation]. University Utrecht; 2018. [cited 2021 Apr 21]. Available from: https://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; https://dspace.library.uu.nl/handle/1874/364927.

Council of Science Editors:

Voormolen EHJ. Computer-Assisted Surgery of the Skull Base : Contributions to Guidance and Imaging. [Doctoral Dissertation]. University Utrecht; 2018. Available from: https://dspace.library.uu.nl/handle/1874/364927 ; URN:NBN:NL:UI:10-1874-364927 ; urn:isbn:978-94-6233-983-5 ; URN:NBN:NL:UI:10-1874-364927 ; https://dspace.library.uu.nl/handle/1874/364927

Texas State University – San Marcos

28. Goots, Alexis. Cranial Base Height as an Indicator of Developmental Stress in Native Mexican and American-Born Mexican Populations.

Degree: MA, Anthropology, 2016, Texas State University – San Marcos

URL: https://digital.library.txstate.edu/handle/10877/6111

► Cranial base height, much like stature, has been used as an indicator of developmental stress in human populations since J. Lawrence Angel first proposed the… (more)

Subjects/Keywords: Cranial Base Height; Developmental Stress; Mexico; Native Mexican; Migrant; Mexican Migrant; Hispanic; Public Policy; Immigration Policy; Anthropology; Forensic Anthropology; Skull base – Measurement; Stress (Physiology); Applied anthropology – United States; Immigrants – United States; Mexicans – United States

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goots, A. (2016). Cranial Base Height as an Indicator of Developmental Stress in Native Mexican and American-Born Mexican Populations. (Masters Thesis). Texas State University – San Marcos. Retrieved from https://digital.library.txstate.edu/handle/10877/6111

Chicago Manual of Style (16^th Edition):

Goots, Alexis. “Cranial Base Height as an Indicator of Developmental Stress in Native Mexican and American-Born Mexican Populations.” 2016. Masters Thesis, Texas State University – San Marcos. Accessed April 21, 2021. https://digital.library.txstate.edu/handle/10877/6111.

MLA Handbook (7^th Edition):

Goots, Alexis. “Cranial Base Height as an Indicator of Developmental Stress in Native Mexican and American-Born Mexican Populations.” 2016. Web. 21 Apr 2021.

Vancouver:

Goots A. Cranial Base Height as an Indicator of Developmental Stress in Native Mexican and American-Born Mexican Populations. [Internet] [Masters thesis]. Texas State University – San Marcos; 2016. [cited 2021 Apr 21]. Available from: https://digital.library.txstate.edu/handle/10877/6111.

Council of Science Editors:

Goots A. Cranial Base Height as an Indicator of Developmental Stress in Native Mexican and American-Born Mexican Populations. [Masters Thesis]. Texas State University – San Marcos; 2016. Available from: https://digital.library.txstate.edu/handle/10877/6111

29. Sastre, Julien. Etude tridimensionnelle de la partie postérieure de la base du crâne chez le fœtus : applications à la détermination de l'âge en anthropologie médico-légale : Functionalization of a new material for drinking water treatment by ballasted flocculation.

Degree: Docteur es, Anthropologie biologique, 2011, Aix-Marseille 2

URL: http://www.theses.fr/2011AIX20715

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La morphométrie géométrique permet la visualisation dynamique 3D de la base du crâne et une prévision de leurs variations liées à la croissance. Le but… (more)

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La morphométrie géométrique permet la visualisation dynamique 3D de la base du crâne et une prévision de leurs variations liées à la croissance. Le but de ce travail est de proposer des méthodes fiables et précises pour estimer l’âge fœtal et caractériser un stade de développement par sa conformation osseuse. Les os temporal, occipital et sphénoïde de 33 fœtus âgés de la 19ème à la 24ème semaine d’aménorrhée (S.A.) ont été reconstruits en 3D et 44 landmarks ont été positionnés. L’étude par morphométrie géométrique a permis de déterminer les maxima de variation morphologique, ainsi que d’étudier les trajectoires ontogénétiques. Les formules établies permettent l’estimation de l’âge à ±2,44 semaines. Les points de césure classiquement utilisés en anthropologie ont été confirmés. Nous avons établi une chronologie des conformations entre la 19ème, la 27ème et la 41ème S.A. L’os sphénoïde et occipital présentent un rythme de croissance commun alors que l’os temporal diffère. Nous avons confirmé ces structures anatomiques comme étant des critères indirects de maturation permettant d’estimer l’âge.

Geometric morphometric techniques allow the 3D visualization of the skull base and a forecast of their related growth variations. The aim of this work is to provide reliable and accurate methods to estimate fetal age and stage of development characterized by bone conformation. The temporal bone, occipital and sphenoid in 33 fetuses aged from the 19th to the 24th week of amenorrhea (W.A) were reconstructed in 3D and 44 landmarks were positioned. Geometric morphometrics was used to determine the maxima of morphological variation and ontogenetic trajectories. The established formulas allow the estimation of age at ±2.44 weeks. Hyphenation points conventionally used in anthropology have been confirmed. We have established a chronology of the conformations between 19th, 27th and 41st WA. The sphenoid and the occipital bone have a common growth rate, while the temporal bone differs. We confirmed these anatomical structures as indirect criteria of maturation to estimate age.

Advisors/Committee Members: Leonetti, Georges (thesis director), Le Gall, Michel (thesis director), Adalian, Pascal (thesis director).

Subjects/Keywords: Base du crâne; Foetus; Estimation de l'âge; Morphométrie géométrique; Morphométrie conventionnelle; Skull base; Fetus; Age estimation; Geometric morphometrics; Conventional morphometrics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sastre, J. (2011). Etude tridimensionnelle de la partie postérieure de la base du crâne chez le fœtus : applications à la détermination de l'âge en anthropologie médico-légale : Functionalization of a new material for drinking water treatment by ballasted flocculation. (Doctoral Dissertation). Aix-Marseille 2. Retrieved from http://www.theses.fr/2011AIX20715

Chicago Manual of Style (16^th Edition):

Sastre, Julien. “Etude tridimensionnelle de la partie postérieure de la base du crâne chez le fœtus : applications à la détermination de l'âge en anthropologie médico-légale : Functionalization of a new material for drinking water treatment by ballasted flocculation.” 2011. Doctoral Dissertation, Aix-Marseille 2. Accessed April 21, 2021. http://www.theses.fr/2011AIX20715.

MLA Handbook (7^th Edition):

Sastre, Julien. “Etude tridimensionnelle de la partie postérieure de la base du crâne chez le fœtus : applications à la détermination de l'âge en anthropologie médico-légale : Functionalization of a new material for drinking water treatment by ballasted flocculation.” 2011. Web. 21 Apr 2021.

Vancouver:

Sastre J. Etude tridimensionnelle de la partie postérieure de la base du crâne chez le fœtus : applications à la détermination de l'âge en anthropologie médico-légale : Functionalization of a new material for drinking water treatment by ballasted flocculation. [Internet] [Doctoral dissertation]. Aix-Marseille 2; 2011. [cited 2021 Apr 21]. Available from: http://www.theses.fr/2011AIX20715.

Council of Science Editors:

Sastre J. Etude tridimensionnelle de la partie postérieure de la base du crâne chez le fœtus : applications à la détermination de l'âge en anthropologie médico-légale : Functionalization of a new material for drinking water treatment by ballasted flocculation. [Doctoral Dissertation]. Aix-Marseille 2; 2011. Available from: http://www.theses.fr/2011AIX20715

30. José Erasmo Dal'Col Lucio. Alterações antropométricas na base do crânio em crianças com craniostenose sagital submetidas à correção cirúrgica.

Degree: 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-24052011-141836/

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Craniostenose é o fechamento precoce de uma ou mais suturas cranianas, levando ao redirecionamento do crescimento craniofacial e à deformidade do crânio. Estudos têm pesquisado… (more)

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Craniostenose é o fechamento precoce de uma ou mais suturas cranianas, levando ao redirecionamento do crescimento craniofacial e à deformidade do crânio. Estudos têm pesquisado o impacto da fusão da sutura sagital na base do crânio, focalizando a morfologia da base do crânio na presença de craniostenose sagital isolada (escafocefalia), enquanto outros têm avaliado o crescimento da base do crânio, antes e após a cirurgia. Este estudo teve como objetivo realizar as medidas antropométricas da base do crânio em crianças com escafocefalia, avaliar a influência da correção cirúrgica no remodelamento da base do crânio e nas medidas antropométricas. Foram operadas 21 crianças com diagnóstico clínico e radiológico de escafocefalia, entre abril de 2007 e outubro de 2008, sendo realizadas medidas antropométricas na base do crânio, antes e após 1 ano do tratamento cirúrgico. As medidas foram o índice craniano (IC), distância entre a crista galli e o tubérculo selar (CG-TS), distância entre a crista galli e o meato acústico interno (CG-MAI), distância entre os forames ovais (FO-FO), distância entre os meatos Acústicos internos (MAI-MAI), o ângulo da base do crânio Â1) e o ângulo entre o násio, centro selar e básio (Â2). Houve normalização do IC em todas as crianças, confirmando um remodelamento craniano adequado. A medida CG-TS avaliou a base do crânio anterior, com crescimento proporcional de 12,5%. O crescimento médio-lateral foi observado pelo aumento das medidas FO-FO de 8,5% e MAI-MAI de 9,5%. A medida CG-MAI teve um crescimento de 7,2%. Não houve diferença estatística nos ângulos basais Â1 e Â2 analisados. O tratamento cirúrgico da escafocefalia levou ao remodelamento da base do crânio, confirmado pelas mudanças das medidas antropométricas realizadas antes e após 1 ano da cirurgia

Craniosynostosis is defined as the premature closure of one or more sutures, leading to redirection of the craniofacial growth and deformity of the skull. Studies have examined the impact of fusion of the sagittal suture in the skull base, focusing on the morphology of the skull base in the presence of isolated sagittal craniosynostosis (scaphocephaly), while others have evaluated the growth of the skull base before and after surgery. This study aims to perform the anthropometric measures of the skull base in children with scaphocephaly to evaluate the influence of surgical repair in the remodeling of the skull base and anthropometric measures. Twenty-one children with clinical and radiological diagnosis of scaphocephaly were operated between April 2007 and October 2008, and anthropometric measures at the base of the skull were performed before and after a year of surgery. The measures were the cranial index (CI), distance between the crista galli and tuberculum sellar (CG-TS), distance between the crista galli and the internal auditory meatus (CG-IAM), distance between the oval foramen (OF-OF) distance between the internal auditory meatus (IAM-IAM), the angle of the skull base (Â1) and the angle between the nasion, center of sella and…

Advisors/Committee Members: Hamilton Matushita, Nivaldo Alonso, Jose Pindaro Pereira Plese, Eduardo de Arnaldo Silva Vellutini, Samuel Tau Zymberg.

Subjects/Keywords: Antropometria; Base do crânio; Craniossinostose; Craniostenose sagital; Escafocefalia; Anthropometry; Sagittal craniosynostosis; Scaphocephaly; Skull base

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lucio, J. E. D. (2011). Alterações antropométricas na base do crânio em crianças com craniostenose sagital submetidas à correção cirúrgica. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5138/tde-24052011-141836/

Chicago Manual of Style (16^th Edition):

Lucio, José Erasmo Dal'Col. “Alterações antropométricas na base do crânio em crianças com craniostenose sagital submetidas à correção cirúrgica.” 2011. Doctoral Dissertation, University of São Paulo. Accessed April 21, 2021. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-24052011-141836/.

MLA Handbook (7^th Edition):

Lucio, José Erasmo Dal'Col. “Alterações antropométricas na base do crânio em crianças com craniostenose sagital submetidas à correção cirúrgica.” 2011. Web. 21 Apr 2021.

Vancouver:

Lucio JED. Alterações antropométricas na base do crânio em crianças com craniostenose sagital submetidas à correção cirúrgica. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Apr 21]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-24052011-141836/.

Council of Science Editors:

Lucio JED. Alterações antropométricas na base do crânio em crianças com craniostenose sagital submetidas à correção cirúrgica. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-24052011-141836/

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