Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for subject:(Sistema purin rgico). Showing records 1 – 2 of 2 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters

1. Vargas, Pedro. Avalia??o da modula??o do receptor purin?rgico P2Y12 pelo clopidogrel no crescimento de c?lulas de glioma.

Degree: 2017, Pontifical Catholic University of Rio Grande do Sul

Submitted by PPG Biologia Celular e Molecular ([email protected]) on 2017-10-11T12:59:22Z No. of bitstreams: 1 PEDRO_VARGAS_DIS.pdf: 3468332 bytes, checksum: 563022a7fa710bed810c652069a0777c (MD5)

Approved for entry into archive by Caroline Xavier ([email protected]) on 2017-10-11T20:09:27Z (GMT) No. of bitstreams: 1 PEDRO_VARGAS_DIS.pdf: 3468332 bytes, checksum: 563022a7fa710bed810c652069a0777c (MD5)

Made available in DSpace on 2017-10-11T20:19:08Z (GMT). No. of bitstreams: 1 PEDRO_VARGAS_DIS.pdf: 3468332 bytes, checksum: 563022a7fa710bed810c652069a0777c (MD5) Previous issue date: 2017-03-10

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

Glioblastoma multiform (GBM) is considered the most aggressive tumors of central nervous system (CNS), and the most lethal among primary tumors presenting low survival prognosis, resistance to radiotherapy and chemotherapy. P2Y12 is considered a chemoreceptor for adenosine diphosphate (ADP). Its expression is documented in some cancer types, such as the C6 lineage of rat glioma, renal carcinoma and colon carcinoma. However, its role in the development of tumour progression and the resistance mechanism in chemotherapy are not well elucidated. Currently, it is well established that normal platelet function is an important factor for the progression of tumors, with thrombocytopenic rats demonstrating a significant reduction of metastases. Clopidogrel bisulfate is a drug, which belongs to the class of antiplatelet agents, being a P2Y12 receptor antagonist whose endogenous ligand is ADP. The aim of the present study was to determine the effects of tumor cells exposed to the treatment with clopidogrel. The C6 rat cell line was sensitive to the drug tested (150 ?M) in the viability and cell counts (69.63 ? 8.70) and (53.05 ? 20.06). Both cell lines showed a significant reduction in the number of colonies after 10 days of treatment with clopidogrel. The U251-MG strain demonstrated a significant increase in the G1 phase and a significant reduction in the S phase in the cell cycle (20.32 ? 3.05) and (19.45 ? 2.35) in the concentration of 500 ?M. Other results demonstrate important antiproliferative activity in both tumor lines, suggesting an important participation of the P2Y12 receptor in this process.

O glioblastoma multiforma (GBM) ? considerado o mais agressivo dos tumores do sistema nervoso central (SNC) e o mais letal entre os tumores prim?rios apresentando baixo progn?stico de sobrevida, resist?ncia ? radioterapia e a quimioterapia. O P2Y12 ? considerado um quimiorreceptor para a adenosina difosfato (ADP). Sua express?o ? documentada em algumas linhagens de c?ncer, como a linhagem C6 de glioma de rato, carcinoma renal e carcinoma de c?lon. Contudo, seu papel no desenvolvimento da sinaliza??o e resposta ? quimioterapia n?o est? bem elucidado. Atualmente, est? bem estabelecido que o funcionamento normal das plaquetas ? um importante fator para a progress?o de tumores, sendo que ratos com trombocitopenia demonstraram uma redu??o…

Advisors/Committee Members: Morrone, Fernanda, Cappellari, Ang?lica Regina.

Subjects/Keywords: Sistema Purin?rgico; Glioblastoma Multiforme; P2Y12; Bissulfato de Clopidogrel; CIENCIAS BIOLOGICAS::BIOLOGIA GERAL

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Vargas, P. (2017). Avalia??o da modula??o do receptor purin?rgico P2Y12 pelo clopidogrel no crescimento de c?lulas de glioma. (Masters Thesis). Pontifical Catholic University of Rio Grande do Sul. Retrieved from http://tede2.pucrs.br/tede2/handle/tede/7692

Chicago Manual of Style (16th Edition):

Vargas, Pedro. “Avalia??o da modula??o do receptor purin?rgico P2Y12 pelo clopidogrel no crescimento de c?lulas de glioma.” 2017. Masters Thesis, Pontifical Catholic University of Rio Grande do Sul. Accessed April 13, 2021. http://tede2.pucrs.br/tede2/handle/tede/7692.

MLA Handbook (7th Edition):

Vargas, Pedro. “Avalia??o da modula??o do receptor purin?rgico P2Y12 pelo clopidogrel no crescimento de c?lulas de glioma.” 2017. Web. 13 Apr 2021.

Vancouver:

Vargas P. Avalia??o da modula??o do receptor purin?rgico P2Y12 pelo clopidogrel no crescimento de c?lulas de glioma. [Internet] [Masters thesis]. Pontifical Catholic University of Rio Grande do Sul; 2017. [cited 2021 Apr 13]. Available from: http://tede2.pucrs.br/tede2/handle/tede/7692.

Council of Science Editors:

Vargas P. Avalia??o da modula??o do receptor purin?rgico P2Y12 pelo clopidogrel no crescimento de c?lulas de glioma. [Masters Thesis]. Pontifical Catholic University of Rio Grande do Sul; 2017. Available from: http://tede2.pucrs.br/tede2/handle/tede/7692

2. Gardani, Carla Fernanda Furtado. Avalia??o das ectonucleotidases como biomarcadores na progress?o do c?ncer de pr?stata.

Degree: 2018, Pontifical Catholic University of Rio Grande do Sul

Submitted by PPG Medicina e Ci?ncias da Sa?de ([email protected]) on 2018-06-14T11:20:47Z No. of bitstreams: 1 CARLA_FERNANDA_FURTADO_GARDANI.pdf: 1897020 bytes, checksum: 89528b1ce682182124c46409102c1c92 (MD5)

Approved for entry into archive by Sheila Dias ([email protected]) on 2018-06-25T13:28:22Z (GMT) No. of bitstreams: 1 CARLA_FERNANDA_FURTADO_GARDANI.pdf: 1897020 bytes, checksum: 89528b1ce682182124c46409102c1c92 (MD5)

Made available in DSpace on 2018-06-25T13:36:30Z (GMT). No. of bitstreams: 1 CARLA_FERNANDA_FURTADO_GARDANI.pdf: 1897020 bytes, checksum: 89528b1ce682182124c46409102c1c92 (MD5) Previous issue date: 2018-03-28

Prostate cancer (PC) is the second most diagnosed neoplasm in men, with the exception of non- melanocytic skin tumors. Its global incidence is 1.1 million cases per year and its mortality rate is around 307,000 deaths. Around the world, there are 3,850,000 CP survivors, since their survival in five years reaches values exceeding 80%. Therefore, adequate stratification in the diagnosis and follow-up of these patients is so relevant. In this study, we aimed of evaluating ATP / ADP / AMP hydrolysis as a prognostic biomarker in the CP; CD39 and CD73 enzymes are known to be responsible for the transformation of ATP or ADP into AMP and into adenosine, respectively. Blood samples were collected from 29 patients treated at the Cruz Alta Oncology and Hematology Center (COHCA) and 17 healthy controls (CS), in order to evaluate the hydrolysis activity of ATP, ADP and AMP and to correlate the data between the cases and controls. In addition, the results of hydrolysis were correlated with recognized prognostic factors as Gleason Score (EG), clinical stage (EC) and PSA levels. The mean age of the selected patients was 63.3 years, 71.4% presented PSA <10 at diagnosis, 82.7% were grouped as low in EG and 48.3% of patients belonged to EC IIB. The results demonstrated statistically significant differences in the nucleotide hydrolysis profiles of the cases and controls. In the CP patients the AMP hydrolysis was higher when compared to the hydrolysis of ATP and ADP. Regarding the clinical staging, it was observed that the hydrolysis of ATP was higher in the initial clinical stages, whereas the AMPase remained high regardless of clinical stage. Therefore, we can conclude that the understanding of the ectonucleotidases activities and their influence on tumor progression can collaborate for the diagnostic and improve the therapeutic approach for this neoplasia.

O c?ncer de pr?stata (CP) ? a segunda neoplasia mais diagnosticada no sexo masculino, excetuando-se os tumores de pele n?o melanoc?ticos, por ano sua incid?ncia mundial ? de 1,1 milh?es de casos e sua taxa de mortalidade de cerca de 307.000 ?bitos. Ao redor do mundo h? 3.850.000 sobreviventes de CP, visto que sua sobrevida em cinco 5 anos chega a valores superiores a 80%. Portanto, a estratifica??o adequada no diagn?stico e no seguimento destes pacientes ? muito relevante. Neste estudo objetivou-se avaliar a hidr?lise dos…

Advisors/Committee Members: Morrone, Fernanda Bueno.

Subjects/Keywords: C?ncer de Pr?stata; Progress?o Tumoral; Sistema Purin?rgico; Ectonucleotidases; CIENCIAS DA SAUDE::MEDICINA

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gardani, C. F. F. (2018). Avalia??o das ectonucleotidases como biomarcadores na progress?o do c?ncer de pr?stata. (Masters Thesis). Pontifical Catholic University of Rio Grande do Sul. Retrieved from http://tede2.pucrs.br/tede2/handle/tede/8163

Chicago Manual of Style (16th Edition):

Gardani, Carla Fernanda Furtado. “Avalia??o das ectonucleotidases como biomarcadores na progress?o do c?ncer de pr?stata.” 2018. Masters Thesis, Pontifical Catholic University of Rio Grande do Sul. Accessed April 13, 2021. http://tede2.pucrs.br/tede2/handle/tede/8163.

MLA Handbook (7th Edition):

Gardani, Carla Fernanda Furtado. “Avalia??o das ectonucleotidases como biomarcadores na progress?o do c?ncer de pr?stata.” 2018. Web. 13 Apr 2021.

Vancouver:

Gardani CFF. Avalia??o das ectonucleotidases como biomarcadores na progress?o do c?ncer de pr?stata. [Internet] [Masters thesis]. Pontifical Catholic University of Rio Grande do Sul; 2018. [cited 2021 Apr 13]. Available from: http://tede2.pucrs.br/tede2/handle/tede/8163.

Council of Science Editors:

Gardani CFF. Avalia??o das ectonucleotidases como biomarcadores na progress?o do c?ncer de pr?stata. [Masters Thesis]. Pontifical Catholic University of Rio Grande do Sul; 2018. Available from: http://tede2.pucrs.br/tede2/handle/tede/8163

.