subject:(Sepsis)

University of Georgia

1. Vasan, Mahalakshmi. Synthesis and immunological properties of Rhizobium sin-1 lipid A and an oligosaccharide derived from the cell wall of Bacillus anthracis.

Degree: PhD, Chemistry, 2008, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/vasan_mahalakshmi_200812_phd

► LPS from Rhizobium sin-1 (R. sin-1) can antagonize the production of tumor necrosis factor alpha (TNF-α) by E. coli LPS in human monocytic cells. Although… (more)

Subjects/Keywords: Sepsis

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APA (6^th Edition):

Vasan, M. (2008). Synthesis and immunological properties of Rhizobium sin-1 lipid A and an oligosaccharide derived from the cell wall of Bacillus anthracis. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/vasan_mahalakshmi_200812_phd

Chicago Manual of Style (16^th Edition):

Vasan, Mahalakshmi. “Synthesis and immunological properties of Rhizobium sin-1 lipid A and an oligosaccharide derived from the cell wall of Bacillus anthracis.” 2008. Doctoral Dissertation, University of Georgia. Accessed February 23, 2020. http://purl.galileo.usg.edu/uga_etd/vasan_mahalakshmi_200812_phd.

MLA Handbook (7^th Edition):

Vasan, Mahalakshmi. “Synthesis and immunological properties of Rhizobium sin-1 lipid A and an oligosaccharide derived from the cell wall of Bacillus anthracis.” 2008. Web. 23 Feb 2020.

Vancouver:

Vasan M. Synthesis and immunological properties of Rhizobium sin-1 lipid A and an oligosaccharide derived from the cell wall of Bacillus anthracis. [Internet] [Doctoral dissertation]. University of Georgia; 2008. [cited 2020 Feb 23]. Available from: http://purl.galileo.usg.edu/uga_etd/vasan_mahalakshmi_200812_phd.

Council of Science Editors:

Vasan M. Synthesis and immunological properties of Rhizobium sin-1 lipid A and an oligosaccharide derived from the cell wall of Bacillus anthracis. [Doctoral Dissertation]. University of Georgia; 2008. Available from: http://purl.galileo.usg.edu/uga_etd/vasan_mahalakshmi_200812_phd

Oregon State University

2. Raman, Ramya. Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood.

Degree: PhD, 2017, Oregon State University

URL: http://hdl.handle.net/1957/61921

► Sepsis is an inflammatory reaction occurring throughout the human body to infections caused by bacteria, fungi, and/or other forms of pathogens. It is essential to… (more)

▼ Sepsis is an inflammatory reaction occurring throughout the human body to infections caused by bacteria, fungi, and/or other forms of pathogens. It is essential to find an alternative treatment method for sepsis, to lessen the dependence on antibiotics. Hemoperfusion is an absorbent device that removes select targets from blood, when passed through it. Recent studies are evaluating methods for treatment of antibiotic resistant bacteria using antimicrobial peptides and bacteriophage (viruses against bacteria) proteins, as an alternate to antibiotic treatment. A promising method is to combine a hemoperfusion device coated with PEO modified antimicrobial peptides and/or bacteriophage proteins to remove endotoxins, released by bacteria but prevent plasma protein/platelet adsorption through the PEO brush layer effect. For this purpose, antimicrobial peptide WLBU2 and bacteriophage derived protein Abc2 were studied. This study demonstrates the ability of WLBU2 to retain endotoxin and bacteria binding abilities when PEO is tethered to a surface. Circular Dichroism demonstrated that the secondary helical structure was retained in the presence of LPS when the peptide was PEGylated indicating that the flexibility of the peptide is not inhibited when PEGylated. PEGylated gold surfaces with terminal WLBU2 demonstrated bacteria and endotoxin capture through Scanning Electron Microscopy (SEM) and Quartz Crystal Microbalance with Dissipation (QCMD). Abc2 protein was modified using Genetic Code Expansion (GCE) to incorporate unnatural amino acid Azide-Phe, which uses click chemistry to bind to specific functional groups. This prevents non-specific binding of the protein on the surface, compared to standard bioconjugation methodologies that enable multiple conformations of the protein to the surface. Click chemistry retains the structure and function of the protein. Surface analysis methods using X-ray Photoelectron Spectroscopy (XPS) and QCMD demonstrated the ability of the protein to be immobilized using click chemistry to F127 with end group terminal Alkyne. LPS binding capabilities of the Abc2 modified surface was demonstrated using FITC-LPS solution depletion assay and QCMD. Polybutadiene-Polyethylene Oxide (PBD-PEO) co-polymers were studied for hemocompatibility on a C18 silane surface. The PBD groups can covalently bind using irradiation to biomedical plastics, unlike current Pluronics, which require expensive and toxic surface coatings. Three varied sizes of copolymers were studied and compared to F127. AFM and QCMD was used to monitor the immobilization dynamics of PEO-PBD diblocks compared to Pluronic F127. Generally, the diblocks had a much lower surface coverage, but P5431 exhibited similar topology and coverage as F127. Hemocompatability was studied by fibrinogen repulsion experiments using QCMD and FITC-fibrinogen solution depletion assays. Patelet activation was studied by SEM. P5843 was more efficient at fibrinogen repulsion but was not as efficient at platelet repulsion as P5431, due to the PEO length difference. … Advisors/Committee Members: Schilke, Kate F. (advisor), Baio, Joe (committee member).

Subjects/Keywords: Sepsis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Raman, R. (2017). Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/61921

Chicago Manual of Style (16^th Edition):

Raman, Ramya. “Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood.” 2017. Doctoral Dissertation, Oregon State University. Accessed February 23, 2020. http://hdl.handle.net/1957/61921.

MLA Handbook (7^th Edition):

Raman, Ramya. “Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood.” 2017. Web. 23 Feb 2020.

Vancouver:

Raman R. Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood. [Internet] [Doctoral dissertation]. Oregon State University; 2017. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/1957/61921.

Council of Science Editors:

Raman R. Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood. [Doctoral Dissertation]. Oregon State University; 2017. Available from: http://hdl.handle.net/1957/61921

3. Hutchins, Noelle A. The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis.

Degree: PhD, Pathobiology, 2013, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:320516/

► This dissertation focuses on the response of liver sinusoidal endothelial cells (LSECs) to experimental sepsis in order to better understand the pathologic processes contributing to… (more)

▼ This dissertation focuses on the response of liver sinusoidal endothelial cells (LSECs) to experimental sepsis in order to better understand the pathologic processes contributing to acute liver injury (ALI) and ultimately multiple organ dysfunction syndrome (MODS). Under homeostatic conditions, the liver doesn’t respond to microbial antigens that travel through the portal vein from the digestive tract. In this regard, LSECs, represent a unique EC population, believed to play a role in maintaining local immune tolerance, in part, through the expression of two tolerogenic molecules, Fas and programmed death ligand-1 (PD-L1). Although these two cell surface molecules initiate independent signaling cascades, their impact on LSEC function during sepsis is unknown. Thus, the central hypothesis of this work was that increased Fas expression on LSECs contributes to sepsis-induced liver injury, while elevated PD-L1 expression on LSECs attempts to sustain the immune tolerant state in the septic liver. This dissertation explores how these two cell surface molecules play a role on LSEC dysfunction in an animal sepsis model (cecal ligation and puncture [CLP]). Sepsis fosters an infiltration of leukocytes, which activate the sinusoidal endothelium, leading to an increase of adhesion molecule expression. Subsequently, we show that LSECs are susceptible to increased vascular permeability and undergo Fas-mediated apoptosis during sepsis by comparing CLP WT and CLP Fas-/- mice. Surprisingly, kupffer cells (KCs) appear to protect LSECs from further sepsis-induced injury by secreting IL-6, and engaging the endothelial IL-6 receptor. In contrast to our hypothesis, increased PD-L1 does not protect LSECs from sepsis-induced injury. PD-L1 gene deficiency in CLP animals actually proves to be beneficial to LSEC survival and permeability, essential aspects of EC function. PD-L1 gene deficiency also decreases STAT3 activation, which has been shown to protect ECs from endotoxin-injury. Unlike the suppression of Fas, which drives LSEC injury, KCs may mediate this PD-L1 driven effect. Overall, the results presented herein suggest that Fas and PD-L1 play important and unanticipated roles in LSEC dysfunction, which develops in response to sepsis, contributing to hepatic injury and/or organ dysfunction. Advisors/Committee Members: Ayala, Alfred (Director), Reichner, Jonathan (Reader), Sharma, Surendra (Reader), Shaw, Sunil (Reader), Stearns-Kurosawa, Deborah (Reader).

Subjects/Keywords: sepsis

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APA (6^th Edition):

Hutchins, N. A. (2013). The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:320516/

Chicago Manual of Style (16^th Edition):

Hutchins, Noelle A. “The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis.” 2013. Doctoral Dissertation, Brown University. Accessed February 23, 2020. https://repository.library.brown.edu/studio/item/bdr:320516/.

MLA Handbook (7^th Edition):

Hutchins, Noelle A. “The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis.” 2013. Web. 23 Feb 2020.

Vancouver:

Hutchins NA. The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis. [Internet] [Doctoral dissertation]. Brown University; 2013. [cited 2020 Feb 23]. Available from: https://repository.library.brown.edu/studio/item/bdr:320516/.

Council of Science Editors:

Hutchins NA. The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis. [Doctoral Dissertation]. Brown University; 2013. Available from: https://repository.library.brown.edu/studio/item/bdr:320516/

4. Léon, Karelle. L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains.

Degree: Docteur es, Sciences de la vie. Physiologie, 2012, Brest

URL: http://www.theses.fr/2012BRES0030

►

Le sepsis, état pathologique lié à une réaction inflammatoire systémique suite à une infection, est lapremière cause de mortalité dans les unités de réanimation médicale… (more)

▼

Le sepsis, état pathologique lié à une réaction inflammatoire systémique suite à une infection, est lapremière cause de mortalité dans les unités de réanimation médicale et de soins intensifs hospitaliers.Parmi les pistes thérapeutiques envisagées, l’hypothermie est un bon candidat. En effet, l’hypothermiemodérée induite augmente la durée de survie de rats septiques. Ce travail avait pour objectifd’apporter des éléments permettant de comprendre et d’identifier les mécanismes responsables decet effet bénéfique. Pour cela, différentes fonctions couramment affectées lors du sepsis(inflammation, stress oxydant, défaillance rénale, capacités de transport de l’oxygène par le sang etéquilibre acide-base) ont été étudiées sur des rats septiques en hypothermie modérée (34°C). Lesrésultats obtenus révèlent que l’hypothermie modérée ralentit de manière significative la production decytokines pro-inflammatoires et tend à exercer une diminution de la production radicalaire systémiquechez les rats septiques. L’apparition de l’acidose métabolique et la défaillance rénale sont égalementretardées. Enfin, alors que le sepsis en normothermie conduit à une diminution de la coopérativité etde l’affinité de l’hémoglobine pour l’oxygène, synonymes d’une adaptation face à des modificationspotentiellement délétères, en hypothermie modérée, ces paramètres ne sont pas modifiés. Cesrésultats concourent à penser que l’hypothermie modérée en ralentissant l’évolution du sepsis permetd’augmenter la durée de survie des rats septiques. Ainsi, l’hypothermie pourrait constituer une pistepour traiter les patients atteints de sepsis sévère dans le but de temporiser l’inflammation et decontrôler l’agression retardant ainsi les défaillances d’organes.

Despite numerous studies over the past twenty years, sepsis, a pathologic state related to a systemicinflammatory response following infection, remains the main cause of death in intensive care units.Among the therapeutic approaches proposed, hypothermia is a good candidate. Indeed, mild inducedhypothermia increased the survival duration of septic rats. This work aimed to provide elements tounderstand and identify the mechanisms responsible for this beneficial effect. Consequently, variousfunctions commonly affected during sepsis (inflammation, oxidative stress, renal failure, oxygen bloodcapacity and acid-base balance) were studied on septic rats maintained in mild induced hypothermia(34°C). The results showed that mild hypothermia significantly slows the cytokine proinflammatoryproduction and tends to exert a decrease in the radical systemic production of septic rats. Theappearance of metabolic acidosis and renal failure are also delayed. Finally, while in normothermiasepsis led to a decrease in the cooperativity and oxygen haemoglobin affinity, synonymous of anadaptation when faced with potential deleterious changes, in mild hypothermia, these parameters arenot modified. These results suggest that by reducing the development of sepsis, mild inducedhypothermia increases the survival duration of septic…

Advisors/Committee Members: L'Her, Erwan (thesis director).

Subjects/Keywords: Hypothermie; Sepsis; Hypothermia; Sepsis; 616.944

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APA (6^th Edition):

Léon, K. (2012). L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains. (Doctoral Dissertation). Brest. Retrieved from http://www.theses.fr/2012BRES0030

Chicago Manual of Style (16^th Edition):

Léon, Karelle. “L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains.” 2012. Doctoral Dissertation, Brest. Accessed February 23, 2020. http://www.theses.fr/2012BRES0030.

MLA Handbook (7^th Edition):

Léon, Karelle. “L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains.” 2012. Web. 23 Feb 2020.

Vancouver:

Léon K. L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains. [Internet] [Doctoral dissertation]. Brest; 2012. [cited 2020 Feb 23]. Available from: http://www.theses.fr/2012BRES0030.

Council of Science Editors:

Léon K. L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains. [Doctoral Dissertation]. Brest; 2012. Available from: http://www.theses.fr/2012BRES0030

University of Georgia

5. ROYCHOWDHURY, ABHIJIT. Synthesis and biological evaluations of peptidoglycan part structures.

Degree: PhD, Chemistry, 2005, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/roychowdhury_abhijit_200508_phd

► Peptidoglycan induces pro-inflammatory responses which may lead to clinical symptoms of sepsis. To address this world-wide health problem, the signal transduction pathway responsible for these… (more)

▼ Peptidoglycan induces pro-inflammatory responses which may lead to clinical symptoms of sepsis. To address this world-wide health problem, the signal transduction pathway responsible for these pro-inflammatory responses needs to be unraveled. This entails a proper understanding of structure-activity relationship of various part structures of peptidoglycan (PGN) with different receptors (CD14, TLR, NOD, PGRP) of the host cell. To unravel the complicated signaling involved, and identify various receptors involved in this pathway several peptidoglycan fragments were synthesized and biologically evaluated. PGN are large polymers composed of alternating ²(1-4)-linked N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) residues, which are cross-linked by short peptide bridges. Lysine is commonly the third amino acid of the peptide moieties of PGN of Gram-positive bacteria while Gram-negative bacteria have a diaminopimelic acid (DAP) residue at this position. Although lysine-containing compounds can be conveniently synthesized by standard solution- or polymer supported approaches, the chemical synthesis of DAP containing fragments is hampered by difficulties in the obtaining of this unusual amino acid. We developed a method to synthesize DAP by a cross metathesis reaction between readily available allyl- and vinyl glycine followed by a reduction of the double bond of the resulting compound. Using the synthetic methodology developed a series of PGN fragments were synthesized and biologically evaluated. Cellular activation studies were performed to evaluate synergism exhibited by these PGN fragments. The role of Nod proteins, a pattern recognition receptors, in synergism was investigated and a SAR with different PGN fragments were performed. Direct binding studies with Peptodoglycan receptor protein (PGRP), another pattern recognition receptor called was also evaluated using surface plasmon resonance to illustrate selectivity of different kinds of PGRPs towards different structural variations of PGN. AcHNHOOOOOHOOOnHOAcHNNHOOOR1HN2OONHH NOR22NH3HNNHR3O1R = H or Cross-linking3R = OH or NH2 2R = H (Lys) Gram-positive PGN = COOH ( DAP) Gram-negative PGNGeneral structure of PGN Advisors/Committee Members: Geert-Jan Boons.

Subjects/Keywords: Sepsis

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APA (6^th Edition):

ROYCHOWDHURY, A. (2005). Synthesis and biological evaluations of peptidoglycan part structures. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/roychowdhury_abhijit_200508_phd

Chicago Manual of Style (16^th Edition):

ROYCHOWDHURY, ABHIJIT. “Synthesis and biological evaluations of peptidoglycan part structures.” 2005. Doctoral Dissertation, University of Georgia. Accessed February 23, 2020. http://purl.galileo.usg.edu/uga_etd/roychowdhury_abhijit_200508_phd.

MLA Handbook (7^th Edition):

ROYCHOWDHURY, ABHIJIT. “Synthesis and biological evaluations of peptidoglycan part structures.” 2005. Web. 23 Feb 2020.

Vancouver:

ROYCHOWDHURY A. Synthesis and biological evaluations of peptidoglycan part structures. [Internet] [Doctoral dissertation]. University of Georgia; 2005. [cited 2020 Feb 23]. Available from: http://purl.galileo.usg.edu/uga_etd/roychowdhury_abhijit_200508_phd.

Council of Science Editors:

ROYCHOWDHURY A. Synthesis and biological evaluations of peptidoglycan part structures. [Doctoral Dissertation]. University of Georgia; 2005. Available from: http://purl.galileo.usg.edu/uga_etd/roychowdhury_abhijit_200508_phd

University of Nairobi

6. Kithinji, Bridget Njathi. Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards .

Degree: 2014, University of Nairobi

URL: http://hdl.handle.net/11295/76154

► Background:Neonatal sepsis is a major contributor to neonatal deaths, accounting for about 26% of all neonatal deaths in Africa. Studies have shown that clinical outcome… (more)

▼ Background:Neonatal sepsis is a major contributor to neonatal deaths, accounting for about 26% of all neonatal deaths in Africa. Studies have shown that clinical outcome for specific conditions, including the risk of death, are correlated with quality of hospital care. Clinical practice guidelines for childhood illnesses, including neonatal sepsis in Kenya are contained in the Ministry of Health Basic Paediatric Protocols. These have been disseminated through Emergency Triage, Assessment and Treatment plus Admission (ETAT+) course since 2007. Objectives:The study set to assess the process of clinical care given to neonates admitted at Kenyatta National Hospital general paediatric wards with a diagnosis of sepsis and to determine the factors associated with mortality. Methodology:This was a hospital based descriptive study involving review of medical records of neonates admitted with the diagnosis of neonatal sepsis at the Kenyatta National Hospital general paediatric wards between January 2011 and December 2011. A total of 385 medical records were evaluated. Data were collected by use of an assessment tool and entered into preformed access spreadsheets and analyzed using statistical package for social sciences (SPSS). Results: Assessment was done based on three domains of care. Total documentation score was 16 (IQR 14-17), recommended first line antibiotic treatment for neonatal sepsis was given in 64.4% and supportive care given at admission was good. Mortality rate was 5.5% with 52.4% deaths occurring within the first 48 hours of admission. Neonates with no change in level of activity, no difficulty breastfeeding and who had no grunting were at a lower risk of dying. Conclusion: Documentation of some aspects of neonatal history was good, antibiotic choice was good though there were dosing errors and initial supportive care was good though monitoring of vital signs was poor. Mortality was significantly associated with short duration of hospital stay, change in level of activity, difficulty breastfeeding and grunting.

Subjects/Keywords: neonatal sepsis

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APA (6^th Edition):

Kithinji, B. N. (2014). Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards . (Thesis). University of Nairobi. Retrieved from http://hdl.handle.net/11295/76154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kithinji, Bridget Njathi. “Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards .” 2014. Thesis, University of Nairobi. Accessed February 23, 2020. http://hdl.handle.net/11295/76154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kithinji, Bridget Njathi. “Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards .” 2014. Web. 23 Feb 2020.

Vancouver:

Kithinji BN. Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards . [Internet] [Thesis]. University of Nairobi; 2014. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/11295/76154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kithinji BN. Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards . [Thesis]. University of Nairobi; 2014. Available from: http://hdl.handle.net/11295/76154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State University – Chico

7. Garton-Lutz, Gay Sharon. Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality .

Degree: 2011, California State University – Chico

URL: http://hdl.handle.net/10211.4/265

► ABSTRACT EVALUATION OF THE IMPACT OF SEPSIS BUNDLES ON SEVERE SEPSIS MORTALITY by Gay Sharon Garton-Lutz Master of Science in Nursing California State University, Chico… (more)

▼ ABSTRACT EVALUATION OF THE IMPACT OF SEPSIS BUNDLES ON SEVERE SEPSIS MORTALITY by Gay Sharon Garton-Lutz Master of Science in Nursing California State University, Chico Fall 2010 In the United States, severe sepsis is common and affects over 750,000 people each year and more than 250,000 of those will die. With an alarming mortality rate of between 28% and 50% or higher, the numbers continue to escalate and no one is exempt from this disease process; severe sepsis knows no boundaries and it affects the young as well as the old. One of the most significant interventions regarding severe sepsis is implementing an early goal-directed therapy plan, a sepsis bundle, within six hours of diagnosis. These therapies are evidenced-based treatments and when initiated early on, can reduce progression into multi-system organ failure and mortality. The purpose of this retrospective study was to review whether implementing a sepsis bundle within six hours of diagnosis of severe sepsis would reduce mortality ix rates. A retrospective review was done using the guidelines established by the Surviving Sepsis Campaign, and included 152 adult subjects admitted via the ED at the Northern Nevada target facility. Seven months of data included 58 pre-bundle patients in 2008 (July 1 thru December 31), and 94 post-bundle patients during the same seven months in 2009. This report summarizes the retrospective review of bundle usage with severe sepsis to determine if mortality rates were reduced at a Northern Nevada community hospital. Deaths due to severe sepsis were overall reduced from 31% (pre-bundles) to 23% after implementing bundles but no statistical significance was noted overall. However, a subset of patients with severe sepsis who had respiratory co-morbidities did have significantly decreased mortality after bundle implementation. Implementation of bundles with patients who have respiratory co-morbidities is strongly recommended, based on these findings. The overall decrease in mortality rates of 8% indicates potential for further research in sepsis bundles. Additional studies might include reviewing sepsis in its earliest stage using the bundles vs. waiting until severe sepsis occurs. Advisors/Committee Members: Fox, Sherry D (advisor).

Subjects/Keywords: Sepsis Mortality

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APA (6^th Edition):

Garton-Lutz, G. S. (2011). Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality . (Thesis). California State University – Chico. Retrieved from http://hdl.handle.net/10211.4/265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garton-Lutz, Gay Sharon. “Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality .” 2011. Thesis, California State University – Chico. Accessed February 23, 2020. http://hdl.handle.net/10211.4/265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garton-Lutz, Gay Sharon. “Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality .” 2011. Web. 23 Feb 2020.

Vancouver:

Garton-Lutz GS. Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality . [Internet] [Thesis]. California State University – Chico; 2011. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10211.4/265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garton-Lutz GS. Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality . [Thesis]. California State University – Chico; 2011. Available from: http://hdl.handle.net/10211.4/265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Helderman, Jennifer. Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates.

Degree: 2009, Wake Forest University

URL: http://hdl.handle.net/10339/14918

► Sepsis in premature infants is associated with long term adverse neurodevelopmental outcome. There have been no previous studies to assess the acute changes in brain… (more)

Subjects/Keywords: sepsis

…intensive care unit PMA postmenstrual age PVL periventricular leukoencephalopathy SAE sepsis… …Sepsis in premature infants is associated with long term adverse neurodevelopmental outcome… …sepsis that may lead to long term adverse neurologic outcomes. The goal of this study was to… …identify acute changes in brain function during sepsis in premature infants through the use of… …additional aEEG recording during their first episode of sepsis. All recordings were assessed for…

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APA (6^th Edition):

Helderman, J. (2009). Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/14918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Helderman, Jennifer. “Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates.” 2009. Thesis, Wake Forest University. Accessed February 23, 2020. http://hdl.handle.net/10339/14918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Helderman, Jennifer. “Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates.” 2009. Web. 23 Feb 2020.

Vancouver:

Helderman J. Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates. [Internet] [Thesis]. Wake Forest University; 2009. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10339/14918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Helderman J. Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates. [Thesis]. Wake Forest University; 2009. Available from: http://hdl.handle.net/10339/14918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

9. Farmasi, Fanni. A septicus betegek prehospitális ellátása .

Degree: DE – Egészségügyi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/265486

► A sepsis előfordulása egyre emelkedő tendenciát mutat világszerte, felismerése mégis nehézségekbe ütközik mind prehospitálisan, mind a hospitális ellátásban egyaránt. Kutatásom során elsősorban arra törekedtem, hogy… (more)

Subjects/Keywords: sepsis

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APA (6^th Edition):

Farmasi, F. (n.d.). A septicus betegek prehospitális ellátása . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/265486

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Farmasi, Fanni. “A septicus betegek prehospitális ellátása .” Thesis, University of Debrecen. Accessed February 23, 2020. http://hdl.handle.net/2437/265486.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Farmasi, Fanni. “A septicus betegek prehospitális ellátása .” Web. 23 Feb 2020.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Farmasi F. A septicus betegek prehospitális ellátása . [Internet] [Thesis]. University of Debrecen; [cited 2020 Feb 23]. Available from: http://hdl.handle.net/2437/265486.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Farmasi F. A septicus betegek prehospitális ellátása . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/265486

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

10. Cadelo Gómez, Luis. Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios.

Degree: 2015, Universidad de Cantabria

URL: http://hdl.handle.net/10902/6341

► La sepsis continúa siendo un problema asistencial de primera magnitud en los servicios de urgencias por la necesidad de una rápida identificación de las formas… (more)

▼ La sepsis continúa siendo un problema asistencial de primera magnitud en los servicios de urgencias por la necesidad de una rápida identificación de las formas graves para el inicio precoz de las medidas de tratamiento. Los modelos predictivos existentes están desarrollados para la predicción de mortalidad y no de riesgo de sepsis grave, disponer de un modelo predictivo de sepsis grave desarrollado para los SUH puede ayudar a su identificación precoz Metodología: Para alcanzar los objetivos del proyecto se plantea un estudio transversal, observacional, retrospectivo, no intervencionista, con generación de un modelo predictivo. Con validación de los resultados a través de muestra diferente a la utilizada para la generación del modelo. Hipótesis: "La Predicción de Sepsis Grave en el entorno de las urgencias es posible usando variables clínicas". Diseño: Desarrollo de modelo predictivo de sepsis grave en el entorno de los SUH mediante aplicación de un modelo de regresión logística utilizando variables accesibles en los primeros minutos de los SUH. Se utilizó la realización de hemocultivo como criterio de selección de los casos. Las definiciones utilizadas son las establecidas en la Conferencia de consenso. El modelo obtenido se evalúa mediante validación externa Resultados: La serie de generación está compuesta de 577 pacientes con criterios de sepsis de los cuales 236 (40%) cumplían criterios de sepsis grave. El análisis univariable identifico 29 variables asociadas a la presencia de sepsis grave entre las analizadas. Introducidas las variables en un modelo de regresión logística utilizando 477 pacientes que contaban con toda la información, se obtuvieron ocho variables que de forma independiente explicaban la presencia de sepsis grave, estratificadas las variables se utilizan los coeficientes β para adjudicar pesos proporcionales a los mismos resultando las siguientes variables y pesos: Edad con peso de 1 por estrato, Tª con 2, TAD y Leucocitos con 3, HCTO 4, IH y Leucemia con 8, y SatO2 con 9. El valor del modelo se obtiene por adicción simple del valor de las ocho variables estratificadas. La rentabilidad del modelo da un ABROC de 0,89 (Ic 95% 0,86-0,93) y el mejor punto de corte en el valor 35. La serie de validación con 762 pacientes de los cuales 663(86,7%) eran sepsis graves dio un ABROC global fue de 0,80 (Ic 95% 0,76-0,85), para la predicción de sepsis grave. La aplicación del punto de corte en el modelo de 40 resulta en un ABROC de 0,72 (Ic 95% 0,67-0,78). Discusión: Los modelos existentes basados en la predicción de mortalidad no han sido diseñados para la identificación de los pacientes con sospecha de sepsis grave en el servicio de urgencias. Los resultados de rentabilidad del modelo obtenido basado en 8 variables con peso ajustado al resultado del análisis de regresión logística tienen una rentabilidad similar a otros modelos predictivos clásicos. Conclusiones: Es posible generar un modelo con ocho variables que establezca el riesgo de padecer sepsis grave en el entorno de los… Advisors/Committee Members: García- Castrillo Riesgo, Luis (advisor), Universidad de Cantabria (other).

Subjects/Keywords: Sepsis

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APA (6^th Edition):

Cadelo Gómez, L. (2015). Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/6341

Chicago Manual of Style (16^th Edition):

Cadelo Gómez, Luis. “Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios.” 2015. Doctoral Dissertation, Universidad de Cantabria. Accessed February 23, 2020. http://hdl.handle.net/10902/6341.

MLA Handbook (7^th Edition):

Cadelo Gómez, Luis. “Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios.” 2015. Web. 23 Feb 2020.

Vancouver:

Cadelo Gómez L. Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2015. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10902/6341.

Council of Science Editors:

Cadelo Gómez L. Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios. [Doctoral Dissertation]. Universidad de Cantabria; 2015. Available from: http://hdl.handle.net/10902/6341

11. Pérez San Martín, Sonia. Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico.

Degree: Máster en Condicionantes Genéticos, Nutricionales y Ambientales del Crecimiento y el Desarrollo, 2017, Universidad de Cantabria

URL: http://hdl.handle.net/10902/12431

► Introducción: La vitamina D desempeña un papel importante en la regulación de la inflamación y protección frente a las infecciones, induciendo la síntesis de péptidos… (more)

Subjects/Keywords: Sepsis

…vi 1. ANTECEDENTES Y JUSTIFICACIÓN DEL TEMA 1.1. SEPSIS La sepsis es una de las… …ido en aumento en los últimos años. La sepsis es un tema importante de salud en la… …actualidad, no sólo por la mortalidad, sino porque los pacientes que sobreviven a la sepsis con… …sepsis La sepsis (del griego sepo, que significa «putrefacción») es una respuesta… …primera conferencia de consenso, en la que se desarrollaron las definiciones iniciales de sepsis…

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APA (6^th Edition):

Pérez San Martín, S. (2017). Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico. (Masters Thesis). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/12431

Chicago Manual of Style (16^th Edition):

Pérez San Martín, Sonia. “Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico.” 2017. Masters Thesis, Universidad de Cantabria. Accessed February 23, 2020. http://hdl.handle.net/10902/12431.

MLA Handbook (7^th Edition):

Pérez San Martín, Sonia. “Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico.” 2017. Web. 23 Feb 2020.

Vancouver:

Pérez San Martín S. Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico. [Internet] [Masters thesis]. Universidad de Cantabria; 2017. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10902/12431.

Council of Science Editors:

Pérez San Martín S. Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico. [Masters Thesis]. Universidad de Cantabria; 2017. Available from: http://hdl.handle.net/10902/12431

Dalhousie University

12. Kianian, Mandana. MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA.

Degree: MS, Department of Pharmacology, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15187

► Impairment of the intestinal microcirculation (IMC) plays a critical role in the pathogenesis of sepsis. Consequently, the protection of the IMC represents a pivotal therapeutic… (more)

Subjects/Keywords: Sepsis endocannabinoid system

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APA (6^th Edition):

Kianian, M. (2012). MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15187

Chicago Manual of Style (16^th Edition):

Kianian, Mandana. “MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA.” 2012. Masters Thesis, Dalhousie University. Accessed February 23, 2020. http://hdl.handle.net/10222/15187.

MLA Handbook (7^th Edition):

Kianian, Mandana. “MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA.” 2012. Web. 23 Feb 2020.

Vancouver:

Kianian M. MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10222/15187.

Council of Science Editors:

Kianian M. MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15187

Dalhousie University

13. Sardinha, Joel. CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS.

Degree: MS, Department of Pharmacology, 2014, Dalhousie University

URL: http://hdl.handle.net/10222/54017

► Sepsis is a critical disease where a dysregulated immune response causes multi-organ dysfunction, leading to organ failure and eventual mortality. Early in the course of… (more)

Subjects/Keywords: Cannabinoids; Microcirculation; Sepsis

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APA (6^th Edition):

Sardinha, J. (2014). CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/54017

Chicago Manual of Style (16^th Edition):

Sardinha, Joel. “CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS.” 2014. Masters Thesis, Dalhousie University. Accessed February 23, 2020. http://hdl.handle.net/10222/54017.

MLA Handbook (7^th Edition):

Sardinha, Joel. “CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS.” 2014. Web. 23 Feb 2020.

Vancouver:

Sardinha J. CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10222/54017.

Council of Science Editors:

Sardinha J. CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/54017

14. Musmacker, Joseph. A Fast PCR Method for Rapid Identification of Infectious Pathogens .

Degree: 2013, California State University – San Marcos

URL: http://hdl.handle.net/10211.8/427

► Sepsis is an acute and life threatening medical condition characterized by a systemic infection (bacterial, fungal, or viral), inflammatory response and eventual organ dysfunction. Sepsis… (more)

Subjects/Keywords: PCR; Sepsis; Pathogen

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APA (6^th Edition):

Musmacker, J. (2013). A Fast PCR Method for Rapid Identification of Infectious Pathogens . (Thesis). California State University – San Marcos. Retrieved from http://hdl.handle.net/10211.8/427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Musmacker, Joseph. “A Fast PCR Method for Rapid Identification of Infectious Pathogens .” 2013. Thesis, California State University – San Marcos. Accessed February 23, 2020. http://hdl.handle.net/10211.8/427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Musmacker, Joseph. “A Fast PCR Method for Rapid Identification of Infectious Pathogens .” 2013. Web. 23 Feb 2020.

Vancouver:

Musmacker J. A Fast PCR Method for Rapid Identification of Infectious Pathogens . [Internet] [Thesis]. California State University – San Marcos; 2013. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10211.8/427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Musmacker J. A Fast PCR Method for Rapid Identification of Infectious Pathogens . [Thesis]. California State University – San Marcos; 2013. Available from: http://hdl.handle.net/10211.8/427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

15. Gould, Travis. Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis.

Degree: PhD, 2016, McMaster University

URL: http://hdl.handle.net/11375/20486

►

Sepsis is a devastating clinical condition characterized by a systemic inflammatory response to infection, with concomitant dysregulated pathological thrombus formation. Although sepsis is triggered by… (more)

▼

Sepsis is a devastating clinical condition characterized by a systemic inflammatory response to infection, with concomitant dysregulated pathological thrombus formation. Although sepsis is triggered by the release of microorganisms and/or microbial toxins into the circulation, the presence of infection itself is rarely the cause of death in these patients. Rather, mortality in sepsis is attributed to irreversible organ damage resulting from prolonged, uncontrolled activation of inflammatory and coagulation pathways within the microcirculation. Despite recent advances in clinical management, treatment continues to be largely supportive in nature. As a result, sepsis remains the leading cause of morbidity and mortality in non-coronary intensive care units with mortality rates ranging from 18-30%. Sepsis-induced mortality is further increased following the development of disseminated intravascular coagulation, a thrombohemorrhagic state defined by a primary thrombotic and secondary hemorrhagic diathesis that may culminate in multi-organ failure. Clinical management of patients with sepsis is challenging and largely limited to supportive therapies, which is in part related to a limited understanding of the underlying pathophysiology. Recently, cell-free DNA (CFDNA) has emerged as an important link between innate immunity, coagulation, and inflammation. Furthermore, we have previously demonstrated that plasma levels of CFDNA have high discriminative power to predict ICU mortality in patients with severe sepsis. Patients with higher plasma concentrations of CFDNA are more likely to face severe complications such as organ dysfunction/failure, and death. The evidence presented in this thesis suggests that CFDNA may not simply be an innocuous marker of disease severity, but may itself exert pathological effects and contribute to the fatal coagulation abnormalities observed in sepsis patients.

Thesis

Doctor of Philosophy (PhD)

Advisors/Committee Members: Liaw, Patricia, Medical Sciences (Blood and Cardiovascular).

Subjects/Keywords: Sepsis; Histone; DNA

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APA (6^th Edition):

Gould, T. (2016). Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/20486

Chicago Manual of Style (16^th Edition):

Gould, Travis. “Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis.” 2016. Doctoral Dissertation, McMaster University. Accessed February 23, 2020. http://hdl.handle.net/11375/20486.

MLA Handbook (7^th Edition):

Gould, Travis. “Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis.” 2016. Web. 23 Feb 2020.

Vancouver:

Gould T. Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis. [Internet] [Doctoral dissertation]. McMaster University; 2016. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/11375/20486.

Council of Science Editors:

Gould T. Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis. [Doctoral Dissertation]. McMaster University; 2016. Available from: http://hdl.handle.net/11375/20486

Universitat de Valencia

16. Pallás Beneyto, Luis Alberto. Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico .

Degree: 2013, Universitat de Valencia

URL: http://hdl.handle.net/10550/34696

Establecer el valor pronóstico de niveles elevados en plasma de interleukina 6 en pacientes que ingresan en UCI con criterios de SIRS y sepsis en relación con la mortalidad y desarrollo de fracaso multiorgánico. Advisors/Committee Members: Sáiz Sánchez, María Carmen (advisor).

Subjects/Keywords: sepsis; interleukina 6

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APA (6^th Edition):

Pallás Beneyto, L. A. (2013). Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico . (Doctoral Dissertation). Universitat de Valencia. Retrieved from http://hdl.handle.net/10550/34696

Chicago Manual of Style (16^th Edition):

Pallás Beneyto, Luis Alberto. “Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico .” 2013. Doctoral Dissertation, Universitat de Valencia. Accessed February 23, 2020. http://hdl.handle.net/10550/34696.

MLA Handbook (7^th Edition):

Pallás Beneyto, Luis Alberto. “Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico .” 2013. Web. 23 Feb 2020.

Vancouver:

Pallás Beneyto LA. Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico . [Internet] [Doctoral dissertation]. Universitat de Valencia; 2013. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10550/34696.

Council of Science Editors:

Pallás Beneyto LA. Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico . [Doctoral Dissertation]. Universitat de Valencia; 2013. Available from: http://hdl.handle.net/10550/34696

University of Manitoba

17. Mohammed, Ashfaque. SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS.

Degree: Immunology, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31616

► Sepsis is an overwhelming systemic inflammatory response to microbial infections. Macrophages are the key innate immune cells that provide the first line of defence against… (more)

▼ Sepsis is an overwhelming systemic inflammatory response to microbial infections. Macrophages are the key innate immune cells that provide the first line of defence against systemic infections during sepsis. Macrophages perform multiple functions during infections such as triggering inflammation, phagocytosis of microbes, and resolution of inflammation. So far, various molecules have been shown to be involved in the regulation of macrophages in inflammatory conditions. However, recently published studies suggest that Semaphorin3E (Sema3E) plays a pivotal role in the immune function of macrophages. The exact role of Sema3E associated with macrophages function in lipopolysaccharide (LPS) induced endotoxemia is unknown. To directly address the involvement of Sema3E in macrophages, we have used Sema3e gene deletion approaches in in vivo and cell-based setups. We found that Sema3e-/- mice displayed initial transient protection from LPS-induced hypothermia. Sema3e-/- mice showed lower inducible nitric oxide synthase (iNOS) expression in peritoneal macrophages without altering the integrity of TLR-4 after LPS injection. Sema3e-/- mice exhibit a lower level of tumour necrosis factor (TNF) and interleukin-6 (IL-6) in peritoneal lavage and serum as compared to wild type (WT) littermates. Bone marrow derived macrophages (BMDMs) from Sema3e-/- mice expressed low levels of pro-inflammatory cytokines and also exhibited significantly down-regulated phosphorylation of STAT3, ERK1/2, and NF-κB, upon LPS exposure. Overall, the current study provides direct evidence that the lack of Sema3E, makes macrophages to become less responsive to LPS by disturbing LPSIII initiated signaling transduction. These findings suggest that the inhibition of Sema3E might be a novel strategy to treat conditions triggered by the excessive production of inflammatory cytokines. Advisors/Committee Members: Gounni, Abdel Soussi (Immunology) (supervisor), Uzonna, Jude (Immunology) Keijzer, Richard (Surgery) (examiningcommittee).

Subjects/Keywords: Sema3E; Sepsis; Macrophages

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APA (6^th Edition):

Mohammed, A. (2016). SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31616

Chicago Manual of Style (16^th Edition):

Mohammed, Ashfaque. “SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS.” 2016. Masters Thesis, University of Manitoba. Accessed February 23, 2020. http://hdl.handle.net/1993/31616.

MLA Handbook (7^th Edition):

Mohammed, Ashfaque. “SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS.” 2016. Web. 23 Feb 2020.

Vancouver:

Mohammed A. SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/1993/31616.

Council of Science Editors:

Mohammed A. SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31616

18. Rantanen, Jemina. 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille .

Degree: 2019, Theseus

URL: http://www.theseus.fi/handle/10024/167383

► Opinnäytetyön tarkoituksena oli selvittää myöhäisleikki-ikäisen eli 3-6-vuotiaan lapsen septistä infektiota; sen aiheuttajia, ennustetta ja vaikuttavuutta, oireita ja kliinisiä löydöksiä sekä siihen liittyvää sairaalan ulkopuolista ensihoitoa.… (more)

▼ Opinnäytetyön tarkoituksena oli selvittää myöhäisleikki-ikäisen eli 3-6-vuotiaan lapsen septistä infektiota; sen aiheuttajia, ennustetta ja vaikuttavuutta, oireita ja kliinisiä löydöksiä sekä siihen liittyvää sairaalan ulkopuolista ensihoitoa. Tarkoituksena oli selvittää myös myöhäisleikki-ikäisten lasten vitaalielintoimintojen normaaleja viitearvoja ja koulutuksen järjestämistä. Työn tavoitteena oli tuottaa koulutus Tampereen ammattikorkeakoulun ensihoitajaopiskelijoille. Koulutuksen tavoitteena oli lisätä ensihoitajaopiskelijoiden tietoutta myöhäisleikki-ikäisen lapsen septiseen infektioon liittyvistä erityispiirteistä ja sen tunnistamisen tärkeydestä. Opinnäytetyö koostettiin kahdesta osasta, joista ensimmäinen osa muodostui teoriaosasta ja toinen toiminnan tuotoksesta, eli koulutuksesta. Opinnäytetyön teoriaosuudessa käsiteltiin lasten näkökulmasta septisen infektion aiheuttajia, ennustetta ja vaikuttavuutta, oireita ja kliinisiä löydöksiä sekä septistä sokkia. Lisäksi teoriaosuudessa käsiteltiin tarkemmin septiseen infektioon liittyvää ensihoitoa myöhäisleikki-ikäisten lasten kohdalla; ensiarviota, tarkennettua tilanarviota ja hoitoa sairaalan ulkopuolisessa ensihoidossa. Teoriaosuudessa on käsitelty myös myöhäisleikki-ikäisten lasten vitaalielintoimintojen normaaleja viitearvoja ja koulutuksen järjestämistä. Ensihoitajaopiskelijoille suunnatussa koulutuksessa asioita käytiin läpi tiivistetysti teoriaosuudessa esiin tulleista aiheista. Opinnäytetyötä tehdessä selvisi, että sepsis on nykyään maailmanlaajuisesti yksi johtavimmista kuolinsyistä lasten tehohoidossa. Tarkoituksenmukainen ja viivytyksettä aloitettu hoito parantaa huomattavasti lapsipotilaiden ennustetta. Tästä syystä sepsiksen mahdollisimman varhainen tunnistaminen on keskeisessä roolissa, jotta lapsipotilas saa mahdollisimman nopeasti tarvitsemaansa hoitoa. Kehittämisehdotuksena olisi pitää enemmän septiseen infektioon liittyvää koulutusta tuleville terveydenhuoltoalan ammattilaisille, jotka työssään mahdollisesti kohtaavat lapsipotilaita. Erityisesti septisen infektion nopean tunnistamisen ja viivytyksettömän hoidon aloittamisen tärkeyttä tulisi korostaa.; This study aims to clarify the causes, prognosis and effectivity, as well as symptoms and clinical findings of septic infections on 3-6-year-old children in out-of-hospital emergency care. The objective is also to clarify normal ranges of vital signs on young children and to organise a training session on the topic. The outcome of this study was to produce a training session for the emergency care students at Tampere University of Applied Sciences. The goal of the training was to increase the emergency care students’ knowledge of the special characteristics of young children’s septic infection, emphasising thus the importance of recognising them. The study comprises two parts. The first part describes the theory of the subject and the second part the training. The theoretical part handles the causes of septic infections, its prognosis and effectivity, symptoms and clinical findings, as…

Subjects/Keywords: sepsis; septinen infektio

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rantanen, J. (2019). 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille . (Thesis). Theseus. Retrieved from http://www.theseus.fi/handle/10024/167383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rantanen, Jemina. “3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille .” 2019. Thesis, Theseus. Accessed February 23, 2020. http://www.theseus.fi/handle/10024/167383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rantanen, Jemina. “3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille .” 2019. Web. 23 Feb 2020.

Vancouver:

Rantanen J. 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille . [Internet] [Thesis]. Theseus; 2019. [cited 2020 Feb 23]. Available from: http://www.theseus.fi/handle/10024/167383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rantanen J. 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille . [Thesis]. Theseus; 2019. Available from: http://www.theseus.fi/handle/10024/167383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

19. Samis, Andrew James Willis. Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model .

Degree: Biology, 2012, Queens University

URL: http://hdl.handle.net/1974/7193

► Sepsis-induced delayed gastric emptying is a significant clinical problem for patients in intensive care units worldwide. A series of studies were carried out to examine… (more)

▼ Sepsis-induced delayed gastric emptying is a significant clinical problem for patients in intensive care units worldwide. A series of studies were carried out to examine the nature and mechanisms of sepsis-induced delayed gastric emptying using a novel mouse model which used a standard food source and was devoid of upper gastrointestinal tract trauma and restraint. Using this model, lipopolysaccharide (LPS) injection produced a dose-dependent decrease in gastric emptying which onset by one hour. LPS produced an alteration in mouse behavior and piloerection at 30 minutes, increased resting respiratory rate at 3 hours, and did not impact body temperature. The onset of sepsis-induced delayed gastric emptying was closer to those centrally-mediated clinical signs of sepsis (altered behavior and piloerection) than to the peripherally-mediated clinical signs (respiratory rate) suggesting a central mechanism. C-Fos activation of the area postrema (AP), the nucleus of the solitary tract (NTS), and the dorsal motor nucleus of the vagus (DMV) was examined 30 minutes after LPS injection which is the onset time for sepsis-induced delayed gastric emptying. LPS exposure produced significantly more activated neurons in the AP and NTS, and less in the DMV. These results may suggest a central mechanism with the AP and NTS inhibiting the DMV. Examination of isolated strips of gastric antrum in a tissue bath showed a decreased contractile response to electrical field stimulation and carbachol after injection of LPS. This occurred at 18 hours post LPS injection, but not at 6 hours. Using the mouse model, sepsis-induced delayed gastric emptying was shown to be occurring at 6 hours when no difference in contractility was measurable suggesting intrinsic changes are not the cause. These studies suggest a new mechanistic paradigm for sepsis-induced delayed gastric emptying in which there is a biphasic response. This involves an initial rapid, centrally-mediated delay in gastric emptying occurring the first hour and followed by an intrinsic tissue-level response several hours later characterized by a decrease in gastric muscle contractility.

Subjects/Keywords: gastric emptying; sepsis

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APA (6^th Edition):

Samis, A. J. W. (2012). Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Samis, Andrew James Willis. “Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model .” 2012. Thesis, Queens University. Accessed February 23, 2020. http://hdl.handle.net/1974/7193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Samis, Andrew James Willis. “Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model .” 2012. Web. 23 Feb 2020.

Vancouver:

Samis AJW. Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model . [Internet] [Thesis]. Queens University; 2012. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/1974/7193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Samis AJW. Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model . [Thesis]. Queens University; 2012. Available from: http://hdl.handle.net/1974/7193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Cuipal Alcalde, Juan Diego. Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015.

Degree: 2016, National University of San Marcos

URL: http://cybertesis.unmsm.edu.pe/handle/cybertesis/4679

►

Introducción: La sepsis neonatal temprana es un cuadro clínico caracterizado por manifestaciones de infección sistémica que aparece en las primeras 72 horas de vida, en… (more)

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Introducción: La sepsis neonatal temprana es un cuadro clínico caracterizado por manifestaciones de infección sistémica que aparece en las primeras 72 horas de vida, en México se encuentran tasas de entre 0.76 y 4.7 por 1000 nacidos vivos, con una letalidad de entre 5.7% y 9%. Objetivos: Determinar las características clínicas de los recién nacidos con sepsis neonatal temprana en el Hospital Nacional Dos de Mayo durante el 2015. Diseño: Estudio descriptivo. Lugar: Hospital Nacional Dos de Mayo. Participantes: Pacientes del servicio de Neonatología diagnosticados con sepsis neonatal temprana posible, probable y confirmada. Intervención: Recolección de datos a través de la base de datos de los pacientes del servicio de Neonatología y revisión de historias clínicas. Resultados: Se incluyeron 479 pacientes, 5.4% fueron confirmados con hemocultivo. 85.4% fueron neonatos a término, el 75.8% tuvo adecuado peso al nacer. El factor de riesgo más frecuente fue la ITU en el tercer trimestre del embarazo. La ictericia fue el signo más común y la PCR > 10 mg/dL el hallazgo de laboratorio más frecuente. El estafilococo coagulasa negativo fue el patógeno aislado en la mayoría de casos. 0.83% del total pacientes fallecieron. Conclusiones: La frecuencia de sepsis neonatal temprana confirmada en el Hospital Nacional Dos de Mayo en el 2015 fue de 9 por 1000 nacidos vivos, la tasa de letalidad fue de 11.5% Palabras clave: Sepsis, neonato, factores de riesgo, signos clínicos, letalidad.

– Introduction: Early-onset neonatal sepsis is a clinical syndrome characterized by manifestations of systemic infection that appears in the first 72 hours of life, in Mexico there are rates between 0.76 and 4.7 per 1000 newborns, with a lethality rate between 5.7 and 9%. Objective: To determinate the clinical features of newborns with early-onset neonatal sepsis in the Dos de Mayo National Hospital during 2015. Design: Descriptive study. Place: Dos de Mayo National Hospital. Participants: Patients from the Neonatology service diagnosed with possible, likely and confirmed early-onset neonatal sepsis. Intervention: Data collection through the Neonatology service patients’ database and clinical record review. Results: 479 patients were included, 5.4% were confirmed by blood culture. 85.4% were term infants, 75.4% had adequate birth weight. The most frequent risk factor was the UTI in the third trimester of pregnancy. Jaundice was the most common sign and CRP > 10 mg/dL the most frequent laboratory finding. Coagulase negative Staphylococcus was the most common insolated pathogen. 0.83% of the patients passed away. Conclusions: The frequency of confirmed early-onset neonatal sepsis in the Dos de Mayo National Hospital during 2015 was 9 per 1000 newborns, the lethality rate was 11.5%. Key words: Sepsis, newborn, risk factor, clinical sign, lethality.

Subjects/Keywords: Sepsis neonatal temprana

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APA (6^th Edition):

Cuipal Alcalde, J. D. (2016). Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015. (Thesis). National University of San Marcos. Retrieved from http://cybertesis.unmsm.edu.pe/handle/cybertesis/4679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cuipal Alcalde, Juan Diego. “Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015.” 2016. Thesis, National University of San Marcos. Accessed February 23, 2020. http://cybertesis.unmsm.edu.pe/handle/cybertesis/4679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cuipal Alcalde, Juan Diego. “Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015.” 2016. Web. 23 Feb 2020.

Vancouver:

Cuipal Alcalde JD. Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015. [Internet] [Thesis]. National University of San Marcos; 2016. [cited 2020 Feb 23]. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/4679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cuipal Alcalde JD. Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015. [Thesis]. National University of San Marcos; 2016. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/4679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

21. Martín Alfonso, Silvia. Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis.

Degree: 2019, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/39459

► La sepsis es uno de los mayores problemas de nuestros días que ha de afronta la sanidad en todo el mundo, siendo una de las… (more)

Subjects/Keywords: Cuidados intensivos; Sepsis

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APA (6^th Edition):

Martín Alfonso, S. (2019). Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/39459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martín Alfonso, Silvia. “Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis.” 2019. Thesis, Universidad de Valladolid. Accessed February 23, 2020. http://uvadoc.uva.es/handle/10324/39459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martín Alfonso, Silvia. “Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis.” 2019. Web. 23 Feb 2020.

Vancouver:

Martín Alfonso S. Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis. [Internet] [Thesis]. Universidad de Valladolid; 2019. [cited 2020 Feb 23]. Available from: http://uvadoc.uva.es/handle/10324/39459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martín Alfonso S. Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis. [Thesis]. Universidad de Valladolid; 2019. Available from: http://uvadoc.uva.es/handle/10324/39459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Lau, Corrina. Improving Early Sepsis Identification on Inpatient Units.

Degree: MSN, 2017, University of San Francisco

URL: https://repository.usfca.edu/capstone/707

► Background: On October 1, 2015, the United States Centers for Medicare and Medicaid Services (CMS) issued a core measure addressing the care of septic… (more)

Subjects/Keywords: sepsis protocol; inpatient unit sepsis; early identification of sepsis; adult patients; sepsis; Clinical nurse leader; Nursing

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APA (6^th Edition):

Lau, C. (2017). Improving Early Sepsis Identification on Inpatient Units. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lau, Corrina. “Improving Early Sepsis Identification on Inpatient Units.” 2017. Thesis, University of San Francisco. Accessed February 23, 2020. https://repository.usfca.edu/capstone/707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lau, Corrina. “Improving Early Sepsis Identification on Inpatient Units.” 2017. Web. 23 Feb 2020.

Vancouver:

Lau C. Improving Early Sepsis Identification on Inpatient Units. [Internet] [Thesis]. University of San Francisco; 2017. [cited 2020 Feb 23]. Available from: https://repository.usfca.edu/capstone/707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lau C. Improving Early Sepsis Identification on Inpatient Units. [Thesis]. University of San Francisco; 2017. Available from: https://repository.usfca.edu/capstone/707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

23. Meng, Jingjing. Mechanisms Underlying Opioid Modulation of Gut Immunity.

Degree: PhD, Pharmacology, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/174874

► Opioids are used widely by clinicians due to their potent analgesic activities and sedative properties. However, opioid use or abuse is associated with multiple adverse… (more)

▼ Opioids are used widely by clinicians due to their potent analgesic activities and sedative properties. However, opioid use or abuse is associated with multiple adverse gastrointestinal (GI) symptoms and higher susceptibility to infection caused by pathogens with gut origin. Both clinical and laboratory studies implied that opioids showed suppressive effects on gut immunity and predisposed critically sick patients to infections while the mechanism underlying this defect is still unknown. In the present study we investigated how opioids modulate gut epithelial barrier function and immune responses of gut associated lymphoid tissue (GALT). We demonstrated significant bacterial translocation from gut lumen to mesenteric lymph node (MLN) and liver following morphine treatment in wild-type (WT) animals that was significantly attenuated in Toll-like receptor (TLR2 and 4) knockout mice. We further observed significant disruption of tight junction protein organization only in the ileum but not in the colon of morphine treated WT animals. Inhibition of myosin light chain kinase (MLCK) blocked the effects of both morphine and TLR ligands, suggesting the role of MLCK in tight junction modulation by TLR. Additionally we determined the immune responses of GALT to polymicrobial sepsis in the presence and absence of opioids by using a murine cecal ligation and puncture model. The results showed that opioids accelerated the mortality rate of polymicrobial sepsis. During sepsis progression, morphine treatment altered gut microbiome and subsequently promoted gram-positive bacterial dissemination, which induced excess IL-17A production in a TLR2-dependent manner, resulting in increased gut permeability, sustained inflammation and higher mortality. This study improved our understanding of the role of morphine in modulating gut barrier functions and the roles of GALT in infection susceptibility, which may provide the potential therapeutic targets for novel drug development and lead to more powerful strategy to control or prevent severe infectious diseases like sepsis especially in the opioid using and abusing population.

Subjects/Keywords: epithelium; gut; immunology; opioid; sepsis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meng, J. (2014). Mechanisms Underlying Opioid Modulation of Gut Immunity. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/174874

Chicago Manual of Style (16^th Edition):

Meng, Jingjing. “Mechanisms Underlying Opioid Modulation of Gut Immunity.” 2014. Doctoral Dissertation, University of Minnesota. Accessed February 23, 2020. http://hdl.handle.net/11299/174874.

MLA Handbook (7^th Edition):

Meng, Jingjing. “Mechanisms Underlying Opioid Modulation of Gut Immunity.” 2014. Web. 23 Feb 2020.

Vancouver:

Meng J. Mechanisms Underlying Opioid Modulation of Gut Immunity. [Internet] [Doctoral dissertation]. University of Minnesota; 2014. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/11299/174874.

Council of Science Editors:

Meng J. Mechanisms Underlying Opioid Modulation of Gut Immunity. [Doctoral Dissertation]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/174874

University of Southern California

24. Ragina, Neli P. Dynamic changes of arginine (L-Arg), citrulline (L-Cit), asymetric dimethylarginine (ADMA), symetric dimethylarginine (SDMA) and L-Arg/ADMA ratio under hemorrhagic shock and sepsis.

Degree: MS, Clinical, Biomedical and Translational Investigations, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/605399/rec/2119

► Nitric Oxide (NO) is a signaling molecule that is essential for all cell and organ functions and plays a critical role in the host immune… (more)

▼ Nitric Oxide (NO) is a signaling molecule that is essential for all cell and organ functions and plays a critical role in the host immune response as it is the effector molecule expressed by the macrophages in response to pathogens. NO has three isoforms NOS1 released by neuronal cells, NOS2 also known as inducible NO (iNO), released by macrophages and inflammatory cells and NOS3 released by cells of the endothelium (eNO). NO released from the endothelium plays a major role in inflammation and infection as it inhibits adhesion of inflammatory cells to the endothelial cell wall and facilitates the aggregation of platelets. In addition, NO is a potent vasodilator and under uncontrolled release, inducible NO is thought to contribute to major vasodilatation mediating septic shock. NO is synthesized from L-Arginine (L-Arg). The precursor of L-Arg is L-Citrulline (L-Cit). L-Cit is synthesized in the enterocytes from L-Glutamine and L-Ornithine precursors through the enzymatic activity of ornithine aminotransferase (OAT) and Ornithine transcarbamylase (OTC). ❧ NO levels can be measured indirectly by the Arg/ADMA ratio; and thus an increase of L-Arg through L-Arg or L-Cit supplementation has been sought in order to increase the NO levels and inhibit ADMA synthesis. This preserves the endothelial and immune function, organ perfusion and mitochondrial biogenesis. ❧ Recent literature has demonstrated that L-Cit is a more efficient and safer modality in preserving the NO homeostasis since L-Arg supplementation was associated with an increase in morbidity and mortality in Intensive Care Unit (ICU) patients. In spite of numerous studies on the importance of L-Arg and L-Cit in maintenance of NO bioavailability, a direct observation of the fluctuations of the aforementioned amino acids in states of hemorrhagic shock and sepsis has not been reported. In the present work we have investigated the dynamic changes in the levels of L-Arg, L-Cit, ADMA, SDMA (another suppressor of NO synthesis), and the Arg/ADMA ratio in a porcine model of hemorrhagic shock and in a rat model of sepsis. ❧ Our results demonstrated that, in porcine model of hemorrhagic shock, an eNO deficit, as demonstrated by a decrease in L-Arg and an increase in ADMA, despite resuscitation, was associated with a decrease in Mean Arterial Pressure (MAP) of approximately 53%, an increase in IL-6, and persisting impairment of end-organ perfusion. We also found that oral L-Cit supplementation during systemic sepsis is associated with an increase of L-Arg bioavailability, a decrease in ADMA and an increase in Arg/ADMA ratio in liver and kidney of septic animals. Moreover we found that L- Cit supplementation was associated with reduced splenic macrophage infiltration. ❧ Based on our findings we propose that the mechanism of an increase in IL-6 in hemorrhagic shock derives from eNO deficiency, and thus the Arg/ADMA ratio could be used as a marker in the ICU to depict more accurately the pathologic mechanism responsible for increased morbidity and mortality in trauma as well as… Advisors/Committee Members: Patino-Sutton, Cecilia (Committee Chair), Zhang, Junfeng (Committee Member), Mack, Wendy Jean (Committee Member).

Subjects/Keywords: citrulline; arginine; hemorrhagic shock; sepsis

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APA (6^th Edition):

Ragina, N. P. (2015). Dynamic changes of arginine (L-Arg), citrulline (L-Cit), asymetric dimethylarginine (ADMA), symetric dimethylarginine (SDMA) and L-Arg/ADMA ratio under hemorrhagic shock and sepsis. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/605399/rec/2119

Chicago Manual of Style (16^th Edition):

Ragina, Neli P. “Dynamic changes of arginine (L-Arg), citrulline (L-Cit), asymetric dimethylarginine (ADMA), symetric dimethylarginine (SDMA) and L-Arg/ADMA ratio under hemorrhagic shock and sepsis.” 2015. Masters Thesis, University of Southern California. Accessed February 23, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/605399/rec/2119.

MLA Handbook (7^th Edition):

Ragina, Neli P. “Dynamic changes of arginine (L-Arg), citrulline (L-Cit), asymetric dimethylarginine (ADMA), symetric dimethylarginine (SDMA) and L-Arg/ADMA ratio under hemorrhagic shock and sepsis.” 2015. Web. 23 Feb 2020.

Vancouver:

Ragina NP. Dynamic changes of arginine (L-Arg), citrulline (L-Cit), asymetric dimethylarginine (ADMA), symetric dimethylarginine (SDMA) and L-Arg/ADMA ratio under hemorrhagic shock and sepsis. [Internet] [Masters thesis]. University of Southern California; 2015. [cited 2020 Feb 23]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/605399/rec/2119.

Council of Science Editors:

Ragina NP. Dynamic changes of arginine (L-Arg), citrulline (L-Cit), asymetric dimethylarginine (ADMA), symetric dimethylarginine (SDMA) and L-Arg/ADMA ratio under hemorrhagic shock and sepsis. [Masters Thesis]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/605399/rec/2119

25. Santos, Rui Pedro Lopes dos. Marcadores bioquímicos de sepsis.

Degree: 2014, Universidade Fernando Pessoa

URL: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489

►

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

A sepsis é uma… (more)

Subjects/Keywords: Sepsis; Biomarcadores; Infeção; Inflamação; Sepsis severa; Choque séptico; Sepsis; Biomarkers; Infection; Inflammation; Severe sepsis; Septic shock

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, R. P. L. d. (2014). Marcadores bioquímicos de sepsis. (Thesis). Universidade Fernando Pessoa. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santos, Rui Pedro Lopes dos. “Marcadores bioquímicos de sepsis.” 2014. Thesis, Universidade Fernando Pessoa. Accessed February 23, 2020. http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santos, Rui Pedro Lopes dos. “Marcadores bioquímicos de sepsis.” 2014. Web. 23 Feb 2020.

Vancouver:

Santos RPLd. Marcadores bioquímicos de sepsis. [Internet] [Thesis]. Universidade Fernando Pessoa; 2014. [cited 2020 Feb 23]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santos RPLd. Marcadores bioquímicos de sepsis. [Thesis]. Universidade Fernando Pessoa; 2014. Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University

26. Theivanthiran, Balamayooran. Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis.

Degree: PhD, Veterinary Pathology and Pathobiology, 2013, Louisiana State University

URL: etd-04102013-190507 ; https://digitalcommons.lsu.edu/gradschool_dissertations/638

► Bacterial pneumonia and sepsis are two important causes of mortality in the world. Emergence of multidrug resistant bacteria has necessitated the development of new treatment… (more)

▼ Bacterial pneumonia and sepsis are two important causes of mortality in the world. Emergence of multidrug resistant bacteria has necessitated the development of new treatment and/or prevention strategies to augment host immune defense. In this context, the innate host defense is critical in clearing pathogenic bacteria from the host. Early neutrophil recruitment is a critical step in a multistep requence leading to bacterial clearance. Pattern recognition receptors (PRRs) play a critical role in the innate immune system. Receptor interacting protein 2 (RIP-2) is an adaptor for the nod-like receptors (NLR) NOD1 and NOD2. Nucleotide oligomerisation domain 2 (NOD2) is an intracellular PRR that is shown to be important for host defense against intracellular bacterial pathogens. However, the role of NOD2 and RIP-2 during Gram-negative bacterial pneumonia and polymicrobial sepsis has not been explored. Thus, we hypothesize that the NOD2/RIP-2 axis is critical for host defense during bacterial pneumonia and sepsis/septic peritonitis. To test this hypothesis, we infected NOD2(NOD2-/-), RIP-2(RIP-2-/-) deficient mice intratracheally (i.t) with E. coli (106 CFUs/mouse) and Klebsiella pneumoniae (103 CFUs/mouse). We observed that NOD2/RIP2 signaling is critical for the host defense during gram-negative pneumonia and poly microbial sepsis. The NOD2/RIP2 axis regulates neutrophil recruitment via IL-17A production. We also found that NOD2/RIP-2 signaling is essential for the production of IL-6 and activation of STAT3. We demonstrated that RIP-2 regulates inflammasome activity that is independent of NOD2 signaling. Taken together, these data demonstrate that the NOD2/RIP-2 axis plays a critical role in neutrophil-mediated host defense through IL-17A production and by inflammasome activation. In cecal ligation puncture (CLP) induced sepsis, RIP2-/- mice show increased mortality with higher bacterial burden in the peritoneum and systemic organs compared to WT controls. We found reduced neutrophil influx IL-17A and IL-1beta levels in the peritoneum of RIP2-/- mice after CLP. Furthermore, we also observed increased systemic inflammation accompanied by vital organ damage in the knockout mice. As a whole our data suggest a critical role of RIP2 in neutrophil recruitment, along with IL-17A and IL-1beta during sepsis.

Subjects/Keywords: sepsis; bacteria; RIP2; NOD2; Pneumonia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Theivanthiran, B. (2013). Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-04102013-190507 ; https://digitalcommons.lsu.edu/gradschool_dissertations/638

Chicago Manual of Style (16^th Edition):

Theivanthiran, Balamayooran. “Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis.” 2013. Doctoral Dissertation, Louisiana State University. Accessed February 23, 2020. etd-04102013-190507 ; https://digitalcommons.lsu.edu/gradschool_dissertations/638.

MLA Handbook (7^th Edition):

Theivanthiran, Balamayooran. “Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis.” 2013. Web. 23 Feb 2020.

Vancouver:

Theivanthiran B. Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis. [Internet] [Doctoral dissertation]. Louisiana State University; 2013. [cited 2020 Feb 23]. Available from: etd-04102013-190507 ; https://digitalcommons.lsu.edu/gradschool_dissertations/638.

Council of Science Editors:

Theivanthiran B. Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis. [Doctoral Dissertation]. Louisiana State University; 2013. Available from: etd-04102013-190507 ; https://digitalcommons.lsu.edu/gradschool_dissertations/638

UCLA

27. Chang, Dong Wook. Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis.

Degree: Clinical Research, 2014, UCLA

URL: http://www.escholarship.org/uc/item/83223909

► Background: Identifying factors associated with do-not-resuscitate (DNR) orders is an informative step in developing strategies to improve their use. As such, a descriptive analysis of… (more)

Subjects/Keywords: Medicine; Do-not-resuscitate; Sepsis

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APA (6^th Edition):

Chang, D. W. (2014). Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/83223909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chang, Dong Wook. “Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis.” 2014. Thesis, UCLA. Accessed February 23, 2020. http://www.escholarship.org/uc/item/83223909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chang, Dong Wook. “Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis.” 2014. Web. 23 Feb 2020.

Vancouver:

Chang DW. Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis. [Internet] [Thesis]. UCLA; 2014. [cited 2020 Feb 23]. Available from: http://www.escholarship.org/uc/item/83223909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chang DW. Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis. [Thesis]. UCLA; 2014. Available from: http://www.escholarship.org/uc/item/83223909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

28. Doulias, Triantafyllos. Η σημασία της αμφοτερόπλευρης επινεφριδεκτομής σε πειραματικό μοντέλο σήψης.

Degree: 2018, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/44170

►

Background: Controversial clinical findings of low-dose hydrocortisone supplementation in septic shock led us to investigate the impact of administration in lethal septic shock in adrenalectomized… (more)

▼

Background: Controversial clinical findings of low-dose hydrocortisone supplementation in septic shock led us to investigate the impact of administration in lethal septic shock in adrenalectomized rats. Materials and methods: After preliminary experiments, to define the intravenous dose of hydrocortisone delivered in bilaterally adrenalectomized rats with serum cortisol level similar to sham rats, survival experiments were run in 75 rats after intraperitoneal challenge with Escherichia coli. Rats were treated with placebo, ertapenem, hydrocortisone, and a combination. Sacrifice experiments were run to measure gene transcripts in whole blood and in the liver and to assess cytokine stimulation of splenocytes and tissue overgrowth. Results: The combination of hydrocortisone and ertapenem was superior to any single treatment and mandatory to achieve survival benefit. Splenocytes from infected rats had decreased production of tumor necrosis factor-alpha (TNFa); this was reversed with hydrocortisone treatment. Hydrocortisone increased the expression of TNF, Il1r2, and Hdac4 and decreased that of Dnmt3a. Bacterial burden of E. coli in kidney was decreased after hydrocortisone treatment. Conclusions: Low dose of hydrocortisone is a mandatory adjunctive to antimicrobial therapy in a rat model of septic shock after bilateral adrenalectomy. The mechanism of action is related to reversal of sepsis-induced immunosuppression through interaction with histone deacetylases and de novo DNA methyltransferases.

Σκοπός Τα αμφιλεγόμενα κλινικά ευρήματα της δράσης της χαμηλής δόσης υδροκορτιζόνης στο σηπτικό σοκ, μας οδήγησε στη διερεύνηση την επίδραση της χορήγησης υδροκορτιζόνης σε ένα ζωικό μοντέλο αρουραίων με αμφοτερόπλευρη αδρεναλεκτομή και σε κατάσταση θανατηφόρου σοκ. Υλικό και Μέθοδοι Μετά από προκαταρκτικά πειράματα προσδιορισμού της ενδοφλέβιας δόσης της υδροκορτιζόνης που η χορήγησης της στους αρουραίους με αμφοτερόπλευρη επινεφριδεκτομή θα επιφέρει επίπεδα κορτιζόλης ορού παρόμοια με τους αρουραίους sham, διεξήχθησαν πειράματα επιβίωσης σε 75 αρουραίους μετά από ενδοπεριτοναϊκή έκχυση Escherichia coli. Οι αρουραίοι υποβλήθηκαν σε θεραπεία με placebo, ertapenem, υδροκορτιζόνη και το συνδυασμό αυτών. Πραγματοποήθηκε θυσία των πειραματοζώων για τη μέτρηση του μεταγραφικού γονιδίου σε ολικό αίμα και στο ήπαρ, καθως και εκτιμήση της διέγερσης της κυτοκίνης των σπληνοκυττάρων και της υπερανάπτυξης του ιστού. Αποτελέσματα. Ο συνδυασμός των υδροκορτιζόνη και ertapenem ήταν ανώτερος από πλευράς επιβίωσης από οποιαδήποτε μονοθεραπεία. Τα σπληνοκύτταρα των προσβληθέντων πειραματοζώων εμφάνισαν μειωμένη παραγωγή του παράγοντα νέκρωσης του όγκου-άλφα (TNFa) κάτι που ανατράπηκε μετα τη θεραπεία με υδροκορτιζόνη. Η χορήγηση υδροκορτιζόνης οδήγησε σε αυξημένη έκφραση των TNF, ILR2 και HDAC4 και μειωμένη έκφραση του DNMT3A. Η παρουσία της E.coli στο νεφρό μειώθηκε μετά τη θεραπεία με υδροκορτιζόνη.ψΣυμπεράσματα Η χαμηλή δόση υδροκορτιζόνης ως συμπληρωματική στην αντιμικροβιακή θεραπεία σε ένα μοντέλο αρουραίου με σηπτικό σοκ μετά από…

Subjects/Keywords: Πειραματικά μοντέλα σήψης; Experimental sepsis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Doulias, T. (2018). Η σημασία της αμφοτερόπλευρης επινεφριδεκτομής σε πειραματικό μοντέλο σήψης. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/44170

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Doulias, Triantafyllos. “Η σημασία της αμφοτερόπλευρης επινεφριδεκτομής σε πειραματικό μοντέλο σήψης.” 2018. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed February 23, 2020. http://hdl.handle.net/10442/hedi/44170.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Doulias, Triantafyllos. “Η σημασία της αμφοτερόπλευρης επινεφριδεκτομής σε πειραματικό μοντέλο σήψης.” 2018. Web. 23 Feb 2020.

Vancouver:

Doulias T. Η σημασία της αμφοτερόπλευρης επινεφριδεκτομής σε πειραματικό μοντέλο σήψης. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2018. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10442/hedi/44170.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Doulias T. Η σημασία της αμφοτερόπλευρης επινεφριδεκτομής σε πειραματικό μοντέλο σήψης. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2018. Available from: http://hdl.handle.net/10442/hedi/44170

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

29. Rochwerg, Bram. RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL.

Degree: MSc, 2015, McMaster University

URL: http://hdl.handle.net/11375/18139

►

This thesis consists of two related studies presented as three separate manuscripts (all three have been published in peer-reviewed journals) and a study protocol that… (more)

▼

This thesis consists of two related studies presented as three separate manuscripts (all three have been published in peer-reviewed journals) and a study protocol that has been submitted for peer-reviewed funding. The over-arching theme of this thesis was to better characterize the efficacy of different intravenous fluids used for the resuscitation of intensive care unit (ICU) patients with severe sepsis or septic shock. We performed an extensive search including multiple databases which found 20 randomized controlled trials (RCTs) that examined the effects of different intravenous fluids used in septic patients and met our a priori inclusion and exclusion criteria. In the first manuscript, we described in detail the composition of the 19 unique fluid products that were used in the various studies. This description included the fluid type, trade name, osmolality, tonicity, electrolyte content, molecular composition, pH, and manufacturer. We reviewed manufacturer’s websites, product monographs, and emailed industry representatives or study authors for more information regarding the fluids as required. The results of this study and systematic review led us to the second and third manuscripts which reported on a Bayesian network meta-analysis (NMA) of all fluid type comparisons. Despite multiple well-done RCTs, comparative data regarding the clinical effect of different resuscitative fluids when used for sepsis was incomplete. Most RCTs used 0.9% saline (normal saline) as control fluid and very few studies compared colloids directly. The advantage of using an NMA model in this setting was the ability to include indirect data into the overall point estimates. Data was abstracted from the 14 studies which focused on adult ICU patients and analyzed examining the outcomes of mortality (manuscript2) and the use of renal replacement therapy (RRT) (manuscript #3). Certainty of evidence was evaluated for both outcomes using the GRADE approach. Results of the analysis clearly document the harm of starch-based fluids when used in septic patients. Albumin containing fluids and crystalloids (such as normal saline and Ringer’s Lactate) are better options. Lower chloride solutions, such as Ringer’s Lactate, showed a signal towards decreased mortality and a decreased use of renal replacement therapy when compared to higher chloride fluids, such as normal saline, however this was based on indirect data, not statistically significant, and warrants direct comparison trials. The final component of this thesis is a pilot study protocol for a study assessing the feasibility of a larger RCT examining the effect of low chloride versus high chloride fluids for resuscitation in patients with sepsis and septic shock. This protocol has been submitted as part of a peer-reviewed grant with the hopes of addressing this clinically important and timely question.

Thesis

Master of Science (MSc)

This thesis examines the ideal intravenous fluid to be given to patients with severe infection causing low blood pressure. A review of…

Advisors/Committee Members: Brozek, Jan, Guyatt, Gordon, Jaeschke, Roman, Health Research Methodology.

Subjects/Keywords: sepsis; network meta-analysis; fluids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rochwerg, B. (2015). RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18139

Chicago Manual of Style (16^th Edition):

Rochwerg, Bram. “RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL.” 2015. Masters Thesis, McMaster University. Accessed February 23, 2020. http://hdl.handle.net/11375/18139.

MLA Handbook (7^th Edition):

Rochwerg, Bram. “RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL.” 2015. Web. 23 Feb 2020.

Vancouver:

Rochwerg B. RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL. [Internet] [Masters thesis]. McMaster University; 2015. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/11375/18139.

Council of Science Editors:

Rochwerg B. RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL. [Masters Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/18139

McMaster University

30. Khan, Momina. Investigating implications and mechanisms of diet induced obesity for multi organ function in a murine model of early sepsis.

Degree: PhD, 2017, McMaster University

URL: http://hdl.handle.net/11375/21972

► Given the current obesity epidemic, the prevalence of overweight and obese patients with critical illness is increasing rapidly, however how obesity shapes critical illness and… (more)

▼ Given the current obesity epidemic, the prevalence of overweight and obese patients with critical illness is increasing rapidly, however how obesity shapes critical illness and immune response to infection is not entirely understood. We developed a clinically relevant murine model of obesity in the context of sepsis, and examined organ specific inflammatory responses. Male C57BL/6 mice were fed either a high fat Western Diet (WD) (Modified Breslow, 21% Butterfat and 0.15% cholesterol) or normal chow diet (NCD) for 6, 15 or 27 weeks. Sepsis was induced by cecal ligation and perforation (CLP), and six hours post-surgery, plasma and tissue samples were harvested and flash frozen in liquid nitrogen. Septic obese mice at 15 and 27 weeks had significantly (p<0.0001) lower levels of lung myeloperoxidase (26.3±3.8 U/mg tissue) compared to age matched ad libitum (44.1±2.8 U/mg tissue) and diet restricted (63.2±5.60 U/mg tissue) controls, indicative of less lung inflammation. Obese mice (4.23±0.10g) had significantly enlarged livers compared to controls (1.55±0.80g and 1.22±0.031g), with pronounced steatosis, and hepatocyte ballooning, independent of sepsis. These findings are in congruence with clinical observations that obese individuals are protected from sepsis-induced lung injury, however the mechanisms involved are not entirely clear. We also examined effects of housing conditions on susceptibility to developing metabolic syndrome, and inflammatory response in our obesity and sepsis model. For this study, animals were fed either WD or NCD for 15 weeks and were housed in static or ventilated cages. Unlike static cages, ventilated cages have HEPA filtered air supply system and exhaust air ventilation, protecting the animals from air borne particles and preserving the microbiological barrier. Therefore, ventilated cages provide a more sterile environment compared to static cages. After 15 weeks, fecal matter was collected from the cages and mice were subjected to sepsis using the CLP technique. Six hours post surgery, animals were sacrificed and tissues were harvested, snap frozen and stored at -80°C. The animals from the more sterile environment (ventilated cages) had significantly (p<0.0001) less weight gain and did not show signs of overt hyperglycemia, compared to mice housed in a less sterile environment (static cages). In addition, obese mice housed in static cages had less lung injury compared to controls during early sepsis, however this difference was not evident in mice from ventilated cages. There were also significant differences in the fecal microbe composition, where ventilated groups had greater Firmicutes (69% ± 0.06% for WD and 76% ± 0.03%) and less Bacteroidetes population (15% ± 0.04% for WD and 12% ± 0.02% for NCD) compared to static groups (Firmicutes: 42% ± 0.08% for WD and 24% ± 0.02% for NCD, Bacteroidetes: 37% ± 12% for WD and 53% ± 29% for NCD). This study highlighted the impact of environment on the susceptibility to developing metabolic syndrome, and the potential impact on the associated… Advisors/Committee Members: Fox-Robichaud, Alison, Medical Sciences.

Subjects/Keywords: obesity; early sepsis; inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khan, M. (2017). Investigating implications and mechanisms of diet induced obesity for multi organ function in a murine model of early sepsis. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/21972

Chicago Manual of Style (16^th Edition):

Khan, Momina. “Investigating implications and mechanisms of diet induced obesity for multi organ function in a murine model of early sepsis.” 2017. Doctoral Dissertation, McMaster University. Accessed February 23, 2020. http://hdl.handle.net/11375/21972.

MLA Handbook (7^th Edition):

Khan, Momina. “Investigating implications and mechanisms of diet induced obesity for multi organ function in a murine model of early sepsis.” 2017. Web. 23 Feb 2020.

Vancouver:

Khan M. Investigating implications and mechanisms of diet induced obesity for multi organ function in a murine model of early sepsis. [Internet] [Doctoral dissertation]. McMaster University; 2017. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/11375/21972.

Council of Science Editors:

Khan M. Investigating implications and mechanisms of diet induced obesity for multi organ function in a murine model of early sepsis. [Doctoral Dissertation]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/21972

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Open Access Theses and Dissertations