subject:(Sepsis)

Oregon State University

1. Raman, Ramya. Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood.

Degree: PhD, 2017, Oregon State University

URL: http://hdl.handle.net/1957/61921

► Sepsis is an inflammatory reaction occurring throughout the human body to infections caused by bacteria, fungi, and/or other forms of pathogens. It is essential to… (more)

▼ Sepsis is an inflammatory reaction occurring throughout the human body to infections caused by bacteria, fungi, and/or other forms of pathogens. It is essential to find an alternative treatment method for sepsis, to lessen the dependence on antibiotics. Hemoperfusion is an absorbent device that removes select targets from blood, when passed through it. Recent studies are evaluating methods for treatment of antibiotic resistant bacteria using antimicrobial peptides and bacteriophage (viruses against bacteria) proteins, as an alternate to antibiotic treatment. A promising method is to combine a hemoperfusion device coated with PEO modified antimicrobial peptides and/or bacteriophage proteins to remove endotoxins, released by bacteria but prevent plasma protein/platelet adsorption through the PEO brush layer effect. For this purpose, antimicrobial peptide WLBU2 and bacteriophage derived protein Abc2 were studied. This study demonstrates the ability of WLBU2 to retain endotoxin and bacteria binding abilities when PEO is tethered to a surface. Circular Dichroism demonstrated that the secondary helical structure was retained in the presence of LPS when the peptide was PEGylated indicating that the flexibility of the peptide is not inhibited when PEGylated. PEGylated gold surfaces with terminal WLBU2 demonstrated bacteria and endotoxin capture through Scanning Electron Microscopy (SEM) and Quartz Crystal Microbalance with Dissipation (QCMD). Abc2 protein was modified using Genetic Code Expansion (GCE) to incorporate unnatural amino acid Azide-Phe, which uses click chemistry to bind to specific functional groups. This prevents non-specific binding of the protein on the surface, compared to standard bioconjugation methodologies that enable multiple conformations of the protein to the surface. Click chemistry retains the structure and function of the protein. Surface analysis methods using X-ray Photoelectron Spectroscopy (XPS) and QCMD demonstrated the ability of the protein to be immobilized using click chemistry to F127 with end group terminal Alkyne. LPS binding capabilities of the Abc2 modified surface was demonstrated using FITC-LPS solution depletion assay and QCMD. Polybutadiene-Polyethylene Oxide (PBD-PEO) co-polymers were studied for hemocompatibility on a C18 silane surface. The PBD groups can covalently bind using irradiation to biomedical plastics, unlike current Pluronics, which require expensive and toxic surface coatings. Three varied sizes of copolymers were studied and compared to F127. AFM and QCMD was used to monitor the immobilization dynamics of PEO-PBD diblocks compared to Pluronic F127. Generally, the diblocks had a much lower surface coverage, but P5431 exhibited similar topology and coverage as F127. Hemocompatability was studied by fibrinogen repulsion experiments using QCMD and FITC-fibrinogen solution depletion assays. Patelet activation was studied by SEM. P5843 was more efficient at fibrinogen repulsion but was not as efficient at platelet repulsion as P5431, due to the PEO length difference. … Advisors/Committee Members: Schilke, Kate F. (advisor), Baio, Joe (committee member).

Subjects/Keywords: Sepsis

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APA (6^th Edition):

Raman, R. (2017). Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/61921

Chicago Manual of Style (16^th Edition):

Raman, Ramya. “Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood.” 2017. Doctoral Dissertation, Oregon State University. Accessed February 27, 2021. http://hdl.handle.net/1957/61921.

MLA Handbook (7^th Edition):

Raman, Ramya. “Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood.” 2017. Web. 27 Feb 2021.

Vancouver:

Raman R. Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood. [Internet] [Doctoral dissertation]. Oregon State University; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1957/61921.

Council of Science Editors:

Raman R. Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood. [Doctoral Dissertation]. Oregon State University; 2017. Available from: http://hdl.handle.net/1957/61921

2. Hutchins, Noelle A. The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis.

Degree: PhD, Pathobiology, 2013, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:320516/

► This dissertation focuses on the response of liver sinusoidal endothelial cells (LSECs) to experimental sepsis in order to better understand the pathologic processes contributing to… (more)

▼ This dissertation focuses on the response of liver sinusoidal endothelial cells (LSECs) to experimental sepsis in order to better understand the pathologic processes contributing to acute liver injury (ALI) and ultimately multiple organ dysfunction syndrome (MODS). Under homeostatic conditions, the liver doesn’t respond to microbial antigens that travel through the portal vein from the digestive tract. In this regard, LSECs, represent a unique EC population, believed to play a role in maintaining local immune tolerance, in part, through the expression of two tolerogenic molecules, Fas and programmed death ligand-1 (PD-L1). Although these two cell surface molecules initiate independent signaling cascades, their impact on LSEC function during sepsis is unknown. Thus, the central hypothesis of this work was that increased Fas expression on LSECs contributes to sepsis-induced liver injury, while elevated PD-L1 expression on LSECs attempts to sustain the immune tolerant state in the septic liver. This dissertation explores how these two cell surface molecules play a role on LSEC dysfunction in an animal sepsis model (cecal ligation and puncture [CLP]). Sepsis fosters an infiltration of leukocytes, which activate the sinusoidal endothelium, leading to an increase of adhesion molecule expression. Subsequently, we show that LSECs are susceptible to increased vascular permeability and undergo Fas-mediated apoptosis during sepsis by comparing CLP WT and CLP Fas-/- mice. Surprisingly, kupffer cells (KCs) appear to protect LSECs from further sepsis-induced injury by secreting IL-6, and engaging the endothelial IL-6 receptor. In contrast to our hypothesis, increased PD-L1 does not protect LSECs from sepsis-induced injury. PD-L1 gene deficiency in CLP animals actually proves to be beneficial to LSEC survival and permeability, essential aspects of EC function. PD-L1 gene deficiency also decreases STAT3 activation, which has been shown to protect ECs from endotoxin-injury. Unlike the suppression of Fas, which drives LSEC injury, KCs may mediate this PD-L1 driven effect. Overall, the results presented herein suggest that Fas and PD-L1 play important and unanticipated roles in LSEC dysfunction, which develops in response to sepsis, contributing to hepatic injury and/or organ dysfunction. Advisors/Committee Members: Ayala, Alfred (Director), Reichner, Jonathan (Reader), Sharma, Surendra (Reader), Shaw, Sunil (Reader), Stearns-Kurosawa, Deborah (Reader).

Subjects/Keywords: sepsis

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APA (6^th Edition):

Hutchins, N. A. (2013). The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:320516/

Chicago Manual of Style (16^th Edition):

Hutchins, Noelle A. “The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis.” 2013. Doctoral Dissertation, Brown University. Accessed February 27, 2021. https://repository.library.brown.edu/studio/item/bdr:320516/.

MLA Handbook (7^th Edition):

Hutchins, Noelle A. “The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis.” 2013. Web. 27 Feb 2021.

Vancouver:

Hutchins NA. The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis. [Internet] [Doctoral dissertation]. Brown University; 2013. [cited 2021 Feb 27]. Available from: https://repository.library.brown.edu/studio/item/bdr:320516/.

Council of Science Editors:

Hutchins NA. The Multifaceted Roles of Fas and PD-L1 on Liver Sinusoidal Endothelial Cell Dysfunction in Sepsis. [Doctoral Dissertation]. Brown University; 2013. Available from: https://repository.library.brown.edu/studio/item/bdr:320516/

East Carolina University

3. Brown, Carolyn C. FACTORS ASSOCIATED WITH THE EARLY IDENTIFICATION OF SEPSIS.

Degree: PhD, PHD-Nursing, 2017, East Carolina University

URL: http://hdl.handle.net/10342/6363

► The incidence of sepsis is increasing and is one of the most frequent causes of death in hospitals in the United States. Sepsis is a… (more)

▼ The incidence of sepsis is increasing and is one of the most frequent causes of death in hospitals in the United States. Sepsis is a heterogeneous clinical syndrome that is difficult to identify in rapid clinical settings such as the emergency department (ED). The purpose of this study was to identify a model that will inform the development of a sepsis screening tool for early recognition of sepsis on arrival to the ED. A retrospective chart review, study sample was obtained from an administrative database. Study data were collected, and prepared, and descriptive and comparison analytics performed. Logistic regression was used for model building. Odds ratios were used to build a scoring tool which was tested for sensitivity and specificity. Most of the sample was White (76.5%), female (51.7%), and lived at home (81.3%). The mean age of sepsis was 64.95 years (SD = 18.73) and the mean age for severe sepsis/septic shock 68.3 years (SD = 14.32). Only 6.7% of individuals with sepsis died, and 25% of individuals with severe sepsis/septic shock died during their hospital stay. Variables were entered into the model in a stepwise process. The final model consisted of five variables: (a) systolic blood pressure [less-than or equal to] 100 mmHg (yes/no), (b) ages [greater-than or equal to] 54 or [less-than or equal to] 80 years (yes/no), (c) respiratory rate [greater-than or equal to] 22 breaths per minute (yes/no), (d) chief complaint of fever or chills (yes/no), and (e) altered mental status or Glasgow Coma Scale [less-than or equal to] 14 (yes/no). The model was statistically significant ( -2 Log Likelihood = 759.80, [chi]2(5) = 71.98, p <.000). A scoring tool was build and each individual in the initial study was scored using the scoring tool. A score [greater-than or equal to] 4 had a sensitivity level 68%, a specificity of 55%, and area under the receiver operating curve of 0.65. The new sepsis tool requires further investigation to improve sensitivity and specificity. Advisors/Committee Members: Crane, Patricia B. (advisor).

Subjects/Keywords: Sepsis

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APA (6^th Edition):

Brown, C. C. (2017). FACTORS ASSOCIATED WITH THE EARLY IDENTIFICATION OF SEPSIS. (Doctoral Dissertation). East Carolina University. Retrieved from http://hdl.handle.net/10342/6363

Chicago Manual of Style (16^th Edition):

Brown, Carolyn C. “FACTORS ASSOCIATED WITH THE EARLY IDENTIFICATION OF SEPSIS.” 2017. Doctoral Dissertation, East Carolina University. Accessed February 27, 2021. http://hdl.handle.net/10342/6363.

MLA Handbook (7^th Edition):

Brown, Carolyn C. “FACTORS ASSOCIATED WITH THE EARLY IDENTIFICATION OF SEPSIS.” 2017. Web. 27 Feb 2021.

Vancouver:

Brown CC. FACTORS ASSOCIATED WITH THE EARLY IDENTIFICATION OF SEPSIS. [Internet] [Doctoral dissertation]. East Carolina University; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10342/6363.

Council of Science Editors:

Brown CC. FACTORS ASSOCIATED WITH THE EARLY IDENTIFICATION OF SEPSIS. [Doctoral Dissertation]. East Carolina University; 2017. Available from: http://hdl.handle.net/10342/6363

Universidad de Cantabria

4. Castro Fernández, Rocío de. Evaluación de la función adrenal en el paciente con sepsis o shock séptico. Cortisol y andrógenos adrenales como marcadores pronósticos de mortalidad: Evaluation of adrenal function in patients with sepsis or septic shock. Cortisol andadrenal androgens as predictors of mortality.

Degree: 2020, Universidad de Cantabria

URL: http://hdl.handle.net/10902/18442

► Objective: To determine the prognostic value of cortisol, Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEAS), and their ratios (Cortisol/DHEA and Cortisol/DHEAS), as independent predictors of mortality in… (more)

Subjects/Keywords: Sepsis

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APA (6^th Edition):

Castro Fernández, R. d. (2020). Evaluación de la función adrenal en el paciente con sepsis o shock séptico. Cortisol y andrógenos adrenales como marcadores pronósticos de mortalidad: Evaluation of adrenal function in patients with sepsis or septic shock. Cortisol andadrenal androgens as predictors of mortality. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/18442

Chicago Manual of Style (16^th Edition):

Castro Fernández, Rocío de. “Evaluación de la función adrenal en el paciente con sepsis o shock séptico. Cortisol y andrógenos adrenales como marcadores pronósticos de mortalidad: Evaluation of adrenal function in patients with sepsis or septic shock. Cortisol andadrenal androgens as predictors of mortality.” 2020. Doctoral Dissertation, Universidad de Cantabria. Accessed February 27, 2021. http://hdl.handle.net/10902/18442.

MLA Handbook (7^th Edition):

Castro Fernández, Rocío de. “Evaluación de la función adrenal en el paciente con sepsis o shock séptico. Cortisol y andrógenos adrenales como marcadores pronósticos de mortalidad: Evaluation of adrenal function in patients with sepsis or septic shock. Cortisol andadrenal androgens as predictors of mortality.” 2020. Web. 27 Feb 2021.

Vancouver:

Castro Fernández Rd. Evaluación de la función adrenal en el paciente con sepsis o shock séptico. Cortisol y andrógenos adrenales como marcadores pronósticos de mortalidad: Evaluation of adrenal function in patients with sepsis or septic shock. Cortisol andadrenal androgens as predictors of mortality. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2020. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10902/18442.

Council of Science Editors:

Castro Fernández Rd. Evaluación de la función adrenal en el paciente con sepsis o shock séptico. Cortisol y andrógenos adrenales como marcadores pronósticos de mortalidad: Evaluation of adrenal function in patients with sepsis or septic shock. Cortisol andadrenal androgens as predictors of mortality. [Doctoral Dissertation]. Universidad de Cantabria; 2020. Available from: http://hdl.handle.net/10902/18442

5. Léon, Karelle. L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains.

Degree: Docteur es, Sciences de la vie. Physiologie, 2012, Brest

URL: http://www.theses.fr/2012BRES0030

►

Le sepsis, état pathologique lié à une réaction inflammatoire systémique suite à une infection, est lapremière cause de mortalité dans les unités de réanimation médicale… (more)

▼

Le sepsis, état pathologique lié à une réaction inflammatoire systémique suite à une infection, est lapremière cause de mortalité dans les unités de réanimation médicale et de soins intensifs hospitaliers.Parmi les pistes thérapeutiques envisagées, l’hypothermie est un bon candidat. En effet, l’hypothermiemodérée induite augmente la durée de survie de rats septiques. Ce travail avait pour objectifd’apporter des éléments permettant de comprendre et d’identifier les mécanismes responsables decet effet bénéfique. Pour cela, différentes fonctions couramment affectées lors du sepsis(inflammation, stress oxydant, défaillance rénale, capacités de transport de l’oxygène par le sang etéquilibre acide-base) ont été étudiées sur des rats septiques en hypothermie modérée (34°C). Lesrésultats obtenus révèlent que l’hypothermie modérée ralentit de manière significative la production decytokines pro-inflammatoires et tend à exercer une diminution de la production radicalaire systémiquechez les rats septiques. L’apparition de l’acidose métabolique et la défaillance rénale sont égalementretardées. Enfin, alors que le sepsis en normothermie conduit à une diminution de la coopérativité etde l’affinité de l’hémoglobine pour l’oxygène, synonymes d’une adaptation face à des modificationspotentiellement délétères, en hypothermie modérée, ces paramètres ne sont pas modifiés. Cesrésultats concourent à penser que l’hypothermie modérée en ralentissant l’évolution du sepsis permetd’augmenter la durée de survie des rats septiques. Ainsi, l’hypothermie pourrait constituer une pistepour traiter les patients atteints de sepsis sévère dans le but de temporiser l’inflammation et decontrôler l’agression retardant ainsi les défaillances d’organes.

Despite numerous studies over the past twenty years, sepsis, a pathologic state related to a systemicinflammatory response following infection, remains the main cause of death in intensive care units.Among the therapeutic approaches proposed, hypothermia is a good candidate. Indeed, mild inducedhypothermia increased the survival duration of septic rats. This work aimed to provide elements tounderstand and identify the mechanisms responsible for this beneficial effect. Consequently, variousfunctions commonly affected during sepsis (inflammation, oxidative stress, renal failure, oxygen bloodcapacity and acid-base balance) were studied on septic rats maintained in mild induced hypothermia(34°C). The results showed that mild hypothermia significantly slows the cytokine proinflammatoryproduction and tends to exert a decrease in the radical systemic production of septic rats. Theappearance of metabolic acidosis and renal failure are also delayed. Finally, while in normothermiasepsis led to a decrease in the cooperativity and oxygen haemoglobin affinity, synonymous of anadaptation when faced with potential deleterious changes, in mild hypothermia, these parameters arenot modified. These results suggest that by reducing the development of sepsis, mild inducedhypothermia increases the survival duration of septic…

Advisors/Committee Members: L'Her, Erwan (thesis director).

Subjects/Keywords: Hypothermie; Sepsis; Hypothermia; Sepsis; 616.944

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APA (6^th Edition):

Léon, K. (2012). L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains. (Doctoral Dissertation). Brest. Retrieved from http://www.theses.fr/2012BRES0030

Chicago Manual of Style (16^th Edition):

Léon, Karelle. “L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains.” 2012. Doctoral Dissertation, Brest. Accessed February 27, 2021. http://www.theses.fr/2012BRES0030.

MLA Handbook (7^th Edition):

Léon, Karelle. “L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains.” 2012. Web. 27 Feb 2021.

Vancouver:

Léon K. L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains. [Internet] [Doctoral dissertation]. Brest; 2012. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2012BRES0030.

Council of Science Editors:

Léon K. L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ? : A Theoretical study of the reaction of hydrogen with CO, H2CO, CH3OH on the surfaces of interstellar dust grains. [Doctoral Dissertation]. Brest; 2012. Available from: http://www.theses.fr/2012BRES0030

University of Nairobi

6. Kithinji, Bridget Njathi. Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards .

Degree: 2014, University of Nairobi

URL: http://hdl.handle.net/11295/76154

► Background:Neonatal sepsis is a major contributor to neonatal deaths, accounting for about 26% of all neonatal deaths in Africa. Studies have shown that clinical outcome… (more)

▼ Background:Neonatal sepsis is a major contributor to neonatal deaths, accounting for about 26% of all neonatal deaths in Africa. Studies have shown that clinical outcome for specific conditions, including the risk of death, are correlated with quality of hospital care. Clinical practice guidelines for childhood illnesses, including neonatal sepsis in Kenya are contained in the Ministry of Health Basic Paediatric Protocols. These have been disseminated through Emergency Triage, Assessment and Treatment plus Admission (ETAT+) course since 2007. Objectives:The study set to assess the process of clinical care given to neonates admitted at Kenyatta National Hospital general paediatric wards with a diagnosis of sepsis and to determine the factors associated with mortality. Methodology:This was a hospital based descriptive study involving review of medical records of neonates admitted with the diagnosis of neonatal sepsis at the Kenyatta National Hospital general paediatric wards between January 2011 and December 2011. A total of 385 medical records were evaluated. Data were collected by use of an assessment tool and entered into preformed access spreadsheets and analyzed using statistical package for social sciences (SPSS). Results: Assessment was done based on three domains of care. Total documentation score was 16 (IQR 14-17), recommended first line antibiotic treatment for neonatal sepsis was given in 64.4% and supportive care given at admission was good. Mortality rate was 5.5% with 52.4% deaths occurring within the first 48 hours of admission. Neonates with no change in level of activity, no difficulty breastfeeding and who had no grunting were at a lower risk of dying. Conclusion: Documentation of some aspects of neonatal history was good, antibiotic choice was good though there were dosing errors and initial supportive care was good though monitoring of vital signs was poor. Mortality was significantly associated with short duration of hospital stay, change in level of activity, difficulty breastfeeding and grunting.

Subjects/Keywords: neonatal sepsis

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APA (6^th Edition):

Kithinji, B. N. (2014). Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards . (Thesis). University of Nairobi. Retrieved from http://hdl.handle.net/11295/76154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kithinji, Bridget Njathi. “Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards .” 2014. Thesis, University of Nairobi. Accessed February 27, 2021. http://hdl.handle.net/11295/76154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kithinji, Bridget Njathi. “Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards .” 2014. Web. 27 Feb 2021.

Vancouver:

Kithinji BN. Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards . [Internet] [Thesis]. University of Nairobi; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11295/76154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kithinji BN. Audit of quality of neonatal sepsis care at Kenyatta National Hospital general paediatric wards . [Thesis]. University of Nairobi; 2014. Available from: http://hdl.handle.net/11295/76154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Helderman, Jennifer. Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates.

Degree: 2009, Wake Forest University

URL: http://hdl.handle.net/10339/14918

► Sepsis in premature infants is associated with long term adverse neurodevelopmental outcome. There have been no previous studies to assess the acute changes in brain… (more)

Subjects/Keywords: sepsis

…intensive care unit PMA postmenstrual age PVL periventricular leukoencephalopathy SAE sepsis… …Sepsis in premature infants is associated with long term adverse neurodevelopmental outcome… …sepsis that may lead to long term adverse neurologic outcomes. The goal of this study was to… …identify acute changes in brain function during sepsis in premature infants through the use of… …additional aEEG recording during their first episode of sepsis. All recordings were assessed for…

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APA (6^th Edition):

Helderman, J. (2009). Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/14918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Helderman, Jennifer. “Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates.” 2009. Thesis, Wake Forest University. Accessed February 27, 2021. http://hdl.handle.net/10339/14918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Helderman, Jennifer. “Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates.” 2009. Web. 27 Feb 2021.

Vancouver:

Helderman J. Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates. [Internet] [Thesis]. Wake Forest University; 2009. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10339/14918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Helderman J. Sepsis Associated Encephalopathy in Extremely Low Gestational Age Neonates. [Thesis]. Wake Forest University; 2009. Available from: http://hdl.handle.net/10339/14918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Pérez San Martín, Sonia. Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico.

Degree: Máster en Condicionantes Genéticos, Nutricionales y Ambientales del Crecimiento y el Desarrollo, 2017, Universidad de Cantabria

URL: http://hdl.handle.net/10902/12431

► Introducción: La vitamina D desempeña un papel importante en la regulación de la inflamación y protección frente a las infecciones, induciendo la síntesis de péptidos… (more)

Subjects/Keywords: Sepsis

…vi 1. ANTECEDENTES Y JUSTIFICACIÓN DEL TEMA 1.1. SEPSIS La sepsis es una de las… …ido en aumento en los últimos años. La sepsis es un tema importante de salud en la… …actualidad, no sólo por la mortalidad, sino porque los pacientes que sobreviven a la sepsis con… …sepsis La sepsis (del griego sepo, que significa «putrefacción») es una respuesta… …primera conferencia de consenso, en la que se desarrollaron las definiciones iniciales de sepsis…

9 more images…

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APA (6^th Edition):

Pérez San Martín, S. (2017). Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico. (Masters Thesis). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/12431

Chicago Manual of Style (16^th Edition):

Pérez San Martín, Sonia. “Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico.” 2017. Masters Thesis, Universidad de Cantabria. Accessed February 27, 2021. http://hdl.handle.net/10902/12431.

MLA Handbook (7^th Edition):

Pérez San Martín, Sonia. “Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico.” 2017. Web. 27 Feb 2021.

Vancouver:

Pérez San Martín S. Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico. [Internet] [Masters thesis]. Universidad de Cantabria; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10902/12431.

Council of Science Editors:

Pérez San Martín S. Deficiencia de 25-hidoroxivitamina D, VDBP y péptidos antimicrobianos vitamina D dependientes en el paciente séptico. [Masters Thesis]. Universidad de Cantabria; 2017. Available from: http://hdl.handle.net/10902/12431

University of Debrecen

9. Farmasi, Fanni. A septicus betegek prehospitális ellátása .

Degree: DE – Egészségügyi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/265486

► A sepsis előfordulása egyre emelkedő tendenciát mutat világszerte, felismerése mégis nehézségekbe ütközik mind prehospitálisan, mind a hospitális ellátásban egyaránt. Kutatásom során elsősorban arra törekedtem, hogy… (more)

Subjects/Keywords: sepsis

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APA (6^th Edition):

Farmasi, F. (n.d.). A septicus betegek prehospitális ellátása . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/265486

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Farmasi, Fanni. “A septicus betegek prehospitális ellátása .” Thesis, University of Debrecen. Accessed February 27, 2021. http://hdl.handle.net/2437/265486.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Farmasi, Fanni. “A septicus betegek prehospitális ellátása .” Web. 27 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Farmasi F. A septicus betegek prehospitális ellátása . [Internet] [Thesis]. University of Debrecen; [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2437/265486.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Farmasi F. A septicus betegek prehospitális ellátása . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/265486

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

10. Cadelo Gómez, Luis. Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios.

Degree: 2015, Universidad de Cantabria

URL: http://hdl.handle.net/10902/6341

► La sepsis continúa siendo un problema asistencial de primera magnitud en los servicios de urgencias por la necesidad de una rápida identificación de las formas… (more)

▼ La sepsis continúa siendo un problema asistencial de primera magnitud en los servicios de urgencias por la necesidad de una rápida identificación de las formas graves para el inicio precoz de las medidas de tratamiento. Los modelos predictivos existentes están desarrollados para la predicción de mortalidad y no de riesgo de sepsis grave, disponer de un modelo predictivo de sepsis grave desarrollado para los SUH puede ayudar a su identificación precoz Metodología: Para alcanzar los objetivos del proyecto se plantea un estudio transversal, observacional, retrospectivo, no intervencionista, con generación de un modelo predictivo. Con validación de los resultados a través de muestra diferente a la utilizada para la generación del modelo. Hipótesis: "La Predicción de Sepsis Grave en el entorno de las urgencias es posible usando variables clínicas". Diseño: Desarrollo de modelo predictivo de sepsis grave en el entorno de los SUH mediante aplicación de un modelo de regresión logística utilizando variables accesibles en los primeros minutos de los SUH. Se utilizó la realización de hemocultivo como criterio de selección de los casos. Las definiciones utilizadas son las establecidas en la Conferencia de consenso. El modelo obtenido se evalúa mediante validación externa Resultados: La serie de generación está compuesta de 577 pacientes con criterios de sepsis de los cuales 236 (40%) cumplían criterios de sepsis grave. El análisis univariable identifico 29 variables asociadas a la presencia de sepsis grave entre las analizadas. Introducidas las variables en un modelo de regresión logística utilizando 477 pacientes que contaban con toda la información, se obtuvieron ocho variables que de forma independiente explicaban la presencia de sepsis grave, estratificadas las variables se utilizan los coeficientes β para adjudicar pesos proporcionales a los mismos resultando las siguientes variables y pesos: Edad con peso de 1 por estrato, Tª con 2, TAD y Leucocitos con 3, HCTO 4, IH y Leucemia con 8, y SatO2 con 9. El valor del modelo se obtiene por adicción simple del valor de las ocho variables estratificadas. La rentabilidad del modelo da un ABROC de 0,89 (Ic 95% 0,86-0,93) y el mejor punto de corte en el valor 35. La serie de validación con 762 pacientes de los cuales 663(86,7%) eran sepsis graves dio un ABROC global fue de 0,80 (Ic 95% 0,76-0,85), para la predicción de sepsis grave. La aplicación del punto de corte en el modelo de 40 resulta en un ABROC de 0,72 (Ic 95% 0,67-0,78). Discusión: Los modelos existentes basados en la predicción de mortalidad no han sido diseñados para la identificación de los pacientes con sospecha de sepsis grave en el servicio de urgencias. Los resultados de rentabilidad del modelo obtenido basado en 8 variables con peso ajustado al resultado del análisis de regresión logística tienen una rentabilidad similar a otros modelos predictivos clásicos. Conclusiones: Es posible generar un modelo con ocho variables que establezca el riesgo de padecer sepsis grave en el entorno de los… Advisors/Committee Members: García- Castrillo Riesgo, Luis (advisor), Universidad de Cantabria (other).

Subjects/Keywords: Sepsis

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APA (6^th Edition):

Cadelo Gómez, L. (2015). Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/6341

Chicago Manual of Style (16^th Edition):

Cadelo Gómez, Luis. “Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios.” 2015. Doctoral Dissertation, Universidad de Cantabria. Accessed February 27, 2021. http://hdl.handle.net/10902/6341.

MLA Handbook (7^th Edition):

Cadelo Gómez, Luis. “Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios.” 2015. Web. 27 Feb 2021.

Vancouver:

Cadelo Gómez L. Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10902/6341.

Council of Science Editors:

Cadelo Gómez L. Marcadores precoces de sepsis grave en los servicios de urgencias hospitalarios. [Doctoral Dissertation]. Universidad de Cantabria; 2015. Available from: http://hdl.handle.net/10902/6341

California State University – Chico

11. Garton-Lutz, Gay Sharon. Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality .

Degree: 2011, California State University – Chico

URL: http://hdl.handle.net/10211.4/265

► ABSTRACT EVALUATION OF THE IMPACT OF SEPSIS BUNDLES ON SEVERE SEPSIS MORTALITY by Gay Sharon Garton-Lutz Master of Science in Nursing California State University, Chico… (more)

▼ ABSTRACT EVALUATION OF THE IMPACT OF SEPSIS BUNDLES ON SEVERE SEPSIS MORTALITY by Gay Sharon Garton-Lutz Master of Science in Nursing California State University, Chico Fall 2010 In the United States, severe sepsis is common and affects over 750,000 people each year and more than 250,000 of those will die. With an alarming mortality rate of between 28% and 50% or higher, the numbers continue to escalate and no one is exempt from this disease process; severe sepsis knows no boundaries and it affects the young as well as the old. One of the most significant interventions regarding severe sepsis is implementing an early goal-directed therapy plan, a sepsis bundle, within six hours of diagnosis. These therapies are evidenced-based treatments and when initiated early on, can reduce progression into multi-system organ failure and mortality. The purpose of this retrospective study was to review whether implementing a sepsis bundle within six hours of diagnosis of severe sepsis would reduce mortality ix rates. A retrospective review was done using the guidelines established by the Surviving Sepsis Campaign, and included 152 adult subjects admitted via the ED at the Northern Nevada target facility. Seven months of data included 58 pre-bundle patients in 2008 (July 1 thru December 31), and 94 post-bundle patients during the same seven months in 2009. This report summarizes the retrospective review of bundle usage with severe sepsis to determine if mortality rates were reduced at a Northern Nevada community hospital. Deaths due to severe sepsis were overall reduced from 31% (pre-bundles) to 23% after implementing bundles but no statistical significance was noted overall. However, a subset of patients with severe sepsis who had respiratory co-morbidities did have significantly decreased mortality after bundle implementation. Implementation of bundles with patients who have respiratory co-morbidities is strongly recommended, based on these findings. The overall decrease in mortality rates of 8% indicates potential for further research in sepsis bundles. Additional studies might include reviewing sepsis in its earliest stage using the bundles vs. waiting until severe sepsis occurs. Advisors/Committee Members: Fox, Sherry D (advisor).

Subjects/Keywords: Sepsis Mortality

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APA (6^th Edition):

Garton-Lutz, G. S. (2011). Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality . (Thesis). California State University – Chico. Retrieved from http://hdl.handle.net/10211.4/265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garton-Lutz, Gay Sharon. “Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality .” 2011. Thesis, California State University – Chico. Accessed February 27, 2021. http://hdl.handle.net/10211.4/265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garton-Lutz, Gay Sharon. “Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality .” 2011. Web. 27 Feb 2021.

Vancouver:

Garton-Lutz GS. Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality . [Internet] [Thesis]. California State University – Chico; 2011. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10211.4/265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garton-Lutz GS. Evaluation of the Impact of Sepsis Bundles on Severe Sepsis Mortality . [Thesis]. California State University – Chico; 2011. Available from: http://hdl.handle.net/10211.4/265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

12. Kianian, Mandana. MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA.

Degree: MS, Department of Pharmacology, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15187

► Impairment of the intestinal microcirculation (IMC) plays a critical role in the pathogenesis of sepsis. Consequently, the protection of the IMC represents a pivotal therapeutic… (more)

Subjects/Keywords: Sepsis endocannabinoid system

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APA (6^th Edition):

Kianian, M. (2012). MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15187

Chicago Manual of Style (16^th Edition):

Kianian, Mandana. “MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA.” 2012. Masters Thesis, Dalhousie University. Accessed February 27, 2021. http://hdl.handle.net/10222/15187.

MLA Handbook (7^th Edition):

Kianian, Mandana. “MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA.” 2012. Web. 27 Feb 2021.

Vancouver:

Kianian M. MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10222/15187.

Council of Science Editors:

Kianian M. MODULATION OF ENDOCANNABINOID SYSTEM IN EXPERIMENTAL ENDOTOXEMIA. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15187

Dalhousie University

13. Sardinha, Joel. CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS.

Degree: MS, Department of Pharmacology, 2014, Dalhousie University

URL: http://hdl.handle.net/10222/54017

► Sepsis is a critical disease where a dysregulated immune response causes multi-organ dysfunction, leading to organ failure and eventual mortality. Early in the course of… (more)

Subjects/Keywords: Cannabinoids; Microcirculation; Sepsis

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APA (6^th Edition):

Sardinha, J. (2014). CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/54017

Chicago Manual of Style (16^th Edition):

Sardinha, Joel. “CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS.” 2014. Masters Thesis, Dalhousie University. Accessed February 27, 2021. http://hdl.handle.net/10222/54017.

MLA Handbook (7^th Edition):

Sardinha, Joel. “CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS.” 2014. Web. 27 Feb 2021.

Vancouver:

Sardinha J. CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10222/54017.

Council of Science Editors:

Sardinha J. CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/54017

McMaster University

14. Gould, Travis. Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis.

Degree: PhD, 2016, McMaster University

URL: http://hdl.handle.net/11375/20486

►

Sepsis is a devastating clinical condition characterized by a systemic inflammatory response to infection, with concomitant dysregulated pathological thrombus formation. Although sepsis is triggered by… (more)

▼

Sepsis is a devastating clinical condition characterized by a systemic inflammatory response to infection, with concomitant dysregulated pathological thrombus formation. Although sepsis is triggered by the release of microorganisms and/or microbial toxins into the circulation, the presence of infection itself is rarely the cause of death in these patients. Rather, mortality in sepsis is attributed to irreversible organ damage resulting from prolonged, uncontrolled activation of inflammatory and coagulation pathways within the microcirculation. Despite recent advances in clinical management, treatment continues to be largely supportive in nature. As a result, sepsis remains the leading cause of morbidity and mortality in non-coronary intensive care units with mortality rates ranging from 18-30%. Sepsis-induced mortality is further increased following the development of disseminated intravascular coagulation, a thrombohemorrhagic state defined by a primary thrombotic and secondary hemorrhagic diathesis that may culminate in multi-organ failure. Clinical management of patients with sepsis is challenging and largely limited to supportive therapies, which is in part related to a limited understanding of the underlying pathophysiology. Recently, cell-free DNA (CFDNA) has emerged as an important link between innate immunity, coagulation, and inflammation. Furthermore, we have previously demonstrated that plasma levels of CFDNA have high discriminative power to predict ICU mortality in patients with severe sepsis. Patients with higher plasma concentrations of CFDNA are more likely to face severe complications such as organ dysfunction/failure, and death. The evidence presented in this thesis suggests that CFDNA may not simply be an innocuous marker of disease severity, but may itself exert pathological effects and contribute to the fatal coagulation abnormalities observed in sepsis patients.

Thesis

Doctor of Philosophy (PhD)

Advisors/Committee Members: Liaw, Patricia, Medical Sciences (Blood and Cardiovascular).

Subjects/Keywords: Sepsis; Histone; DNA

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APA (6^th Edition):

Gould, T. (2016). Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/20486

Chicago Manual of Style (16^th Edition):

Gould, Travis. “Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis.” 2016. Doctoral Dissertation, McMaster University. Accessed February 27, 2021. http://hdl.handle.net/11375/20486.

MLA Handbook (7^th Edition):

Gould, Travis. “Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis.” 2016. Web. 27 Feb 2021.

Vancouver:

Gould T. Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis. [Internet] [Doctoral dissertation]. McMaster University; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11375/20486.

Council of Science Editors:

Gould T. Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis. [Doctoral Dissertation]. McMaster University; 2016. Available from: http://hdl.handle.net/11375/20486

Universidad de Valladolid

15. Martín Alfonso, Silvia. Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis.

Degree: 2019, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/39459

► La sepsis es uno de los mayores problemas de nuestros días que ha de afronta la sanidad en todo el mundo, siendo una de las… (more)

Subjects/Keywords: Cuidados intensivos; Sepsis

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APA (6^th Edition):

Martín Alfonso, S. (2019). Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/39459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martín Alfonso, Silvia. “Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis.” 2019. Thesis, Universidad de Valladolid. Accessed February 27, 2021. http://uvadoc.uva.es/handle/10324/39459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martín Alfonso, Silvia. “Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis.” 2019. Web. 27 Feb 2021.

Vancouver:

Martín Alfonso S. Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis. [Internet] [Thesis]. Universidad de Valladolid; 2019. [cited 2021 Feb 27]. Available from: http://uvadoc.uva.es/handle/10324/39459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martín Alfonso S. Cuantificación de la expresión de genes de la sinapsis inmunológica por PCR digital: aplicaciones en la sepsis. [Thesis]. Universidad de Valladolid; 2019. Available from: http://uvadoc.uva.es/handle/10324/39459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

16. Mohammed, Ashfaque. SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS.

Degree: Immunology, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31616

► Sepsis is an overwhelming systemic inflammatory response to microbial infections. Macrophages are the key innate immune cells that provide the first line of defence against… (more)

▼ Sepsis is an overwhelming systemic inflammatory response to microbial infections. Macrophages are the key innate immune cells that provide the first line of defence against systemic infections during sepsis. Macrophages perform multiple functions during infections such as triggering inflammation, phagocytosis of microbes, and resolution of inflammation. So far, various molecules have been shown to be involved in the regulation of macrophages in inflammatory conditions. However, recently published studies suggest that Semaphorin3E (Sema3E) plays a pivotal role in the immune function of macrophages. The exact role of Sema3E associated with macrophages function in lipopolysaccharide (LPS) induced endotoxemia is unknown. To directly address the involvement of Sema3E in macrophages, we have used Sema3e gene deletion approaches in in vivo and cell-based setups. We found that Sema3e-/- mice displayed initial transient protection from LPS-induced hypothermia. Sema3e-/- mice showed lower inducible nitric oxide synthase (iNOS) expression in peritoneal macrophages without altering the integrity of TLR-4 after LPS injection. Sema3e-/- mice exhibit a lower level of tumour necrosis factor (TNF) and interleukin-6 (IL-6) in peritoneal lavage and serum as compared to wild type (WT) littermates. Bone marrow derived macrophages (BMDMs) from Sema3e-/- mice expressed low levels of pro-inflammatory cytokines and also exhibited significantly down-regulated phosphorylation of STAT3, ERK1/2, and NF-κB, upon LPS exposure. Overall, the current study provides direct evidence that the lack of Sema3E, makes macrophages to become less responsive to LPS by disturbing LPSIII initiated signaling transduction. These findings suggest that the inhibition of Sema3E might be a novel strategy to treat conditions triggered by the excessive production of inflammatory cytokines. Advisors/Committee Members: Gounni, Abdel Soussi (Immunology) (supervisor), Uzonna, Jude (Immunology) Keijzer, Richard (Surgery) (examiningcommittee).

Subjects/Keywords: Sema3E; Sepsis; Macrophages

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APA (6^th Edition):

Mohammed, A. (2016). SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31616

Chicago Manual of Style (16^th Edition):

Mohammed, Ashfaque. “SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS.” 2016. Masters Thesis, University of Manitoba. Accessed February 27, 2021. http://hdl.handle.net/1993/31616.

MLA Handbook (7^th Edition):

Mohammed, Ashfaque. “SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS.” 2016. Web. 27 Feb 2021.

Vancouver:

Mohammed A. SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1993/31616.

Council of Science Editors:

Mohammed A. SEMA3E REGULATES RESIDENT MACROPHAGES RESPONSE IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31616

17. Hiltula, Saara-Maria. 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille.

Degree: 2019, Theseus

URL: http://www.theseus.fi/handle/10024/167383

►

Opinnäytetyön tarkoituksena oli selvittää myöhäisleikki-ikäisen eli 3-6-vuotiaan lapsen septistä infektiota; sen aiheuttajia, ennustetta ja vaikuttavuutta, oireita ja kliinisiä löydöksiä sekä siihen liittyvää sairaalan ulkopuolista ensihoitoa.… (more)

▼

Opinnäytetyön tarkoituksena oli selvittää myöhäisleikki-ikäisen eli 3-6-vuotiaan lapsen septistä infektiota; sen aiheuttajia, ennustetta ja vaikuttavuutta, oireita ja kliinisiä löydöksiä sekä siihen liittyvää sairaalan ulkopuolista ensihoitoa. Tarkoituksena oli selvittää myös myöhäisleikki-ikäisten lasten vitaalielintoimintojen normaaleja viitearvoja ja koulutuksen järjestämistä. Työn tavoitteena oli tuottaa koulutus Tampereen ammattikorkeakoulun ensihoitajaopiskelijoille. Koulutuksen tavoitteena oli lisätä ensihoitajaopiskelijoiden tietoutta myöhäisleikki-ikäisen lapsen septiseen infektioon liittyvistä erityispiirteistä ja sen tunnistamisen tärkeydestä. Opinnäytetyö koostettiin kahdesta osasta, joista ensimmäinen osa muodostui teoriaosasta ja toinen toiminnan tuotoksesta, eli koulutuksesta. Opinnäytetyön teoriaosuudessa käsiteltiin lasten näkökulmasta septisen infektion aiheuttajia, ennustetta ja vaikuttavuutta, oireita ja kliinisiä löydöksiä sekä septistä sokkia. Lisäksi teoriaosuudessa käsiteltiin tarkemmin septiseen infektioon liittyvää ensihoitoa myöhäisleikki-ikäisten lasten kohdalla; ensiarviota, tarkennettua tilanarviota ja hoitoa sairaalan ulkopuolisessa ensihoidossa. Teoriaosuudessa on käsitelty myös myöhäisleikki-ikäisten lasten vitaalielintoimintojen normaaleja viitearvoja ja koulutuksen järjestämistä. Ensihoitajaopiskelijoille suunnatussa koulutuksessa asioita käytiin läpi tiivistetysti teoriaosuudessa esiin tulleista aiheista. Opinnäytetyötä tehdessä selvisi, että sepsis on nykyään maailmanlaajuisesti yksi johtavimmista kuolinsyistä lasten tehohoidossa. Tarkoituksenmukainen ja viivytyksettä aloitettu hoito parantaa huomattavasti lapsipotilaiden ennustetta. Tästä syystä sepsiksen mahdollisimman varhainen tunnistaminen on keskeisessä roolissa, jotta lapsipotilas saa mahdollisimman nopeasti tarvitsemaansa hoitoa. Kehittämisehdotuksena olisi pitää enemmän septiseen infektioon liittyvää koulutusta tuleville terveydenhuoltoalan ammattilaisille, jotka työssään mahdollisesti kohtaavat lapsipotilaita. Erityisesti septisen infektion nopean tunnistamisen ja viivytyksettömän hoidon aloittamisen tärkeyttä tulisi korostaa.

This study aims to clarify the causes, prognosis and effectivity, as well as symptoms and clinical findings of septic infections on 3-6-year-old children in out-of-hospital emergency care. The objective is also to clarify normal ranges of vital signs on young children and to organise a training session on the topic. The outcome of this study was to produce a training session for the emergency care students at Tampere University of Applied Sciences. The goal of the training was to increase the emergency care students’ knowledge of the special characteristics of young children’s septic infection, emphasising thus the importance of recognising them. The study comprises two parts. The first part describes the theory of the subject and the second part the training. The theoretical part handles the causes of septic infections, its prognosis and effectivity, symptoms and clinical findings,…

Subjects/Keywords: sepsis; septinen infektio

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APA (6^th Edition):

Hiltula, S. (2019). 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille. (Thesis). Theseus. Retrieved from http://www.theseus.fi/handle/10024/167383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hiltula, Saara-Maria. “3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille.” 2019. Thesis, Theseus. Accessed February 27, 2021. http://www.theseus.fi/handle/10024/167383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hiltula, Saara-Maria. “3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille.” 2019. Web. 27 Feb 2021.

Vancouver:

Hiltula S. 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille. [Internet] [Thesis]. Theseus; 2019. [cited 2021 Feb 27]. Available from: http://www.theseus.fi/handle/10024/167383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hiltula S. 3-6-vuotiaan lapsen septinen infektio sairaalan ulkopuolisessa ensihoidossa : koulutus ensihoitajaopiskelijoille. [Thesis]. Theseus; 2019. Available from: http://www.theseus.fi/handle/10024/167383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Musmacker, Joseph. A Fast PCR Method for Rapid Identification of Infectious Pathogens .

Degree: 2013, California State University – San Marcos

URL: http://hdl.handle.net/10211.8/427

► Sepsis is an acute and life threatening medical condition characterized by a systemic infection (bacterial, fungal, or viral), inflammatory response and eventual organ dysfunction. Sepsis… (more)

Subjects/Keywords: PCR; Sepsis; Pathogen

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APA (6^th Edition):

Musmacker, J. (2013). A Fast PCR Method for Rapid Identification of Infectious Pathogens . (Thesis). California State University – San Marcos. Retrieved from http://hdl.handle.net/10211.8/427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Musmacker, Joseph. “A Fast PCR Method for Rapid Identification of Infectious Pathogens .” 2013. Thesis, California State University – San Marcos. Accessed February 27, 2021. http://hdl.handle.net/10211.8/427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Musmacker, Joseph. “A Fast PCR Method for Rapid Identification of Infectious Pathogens .” 2013. Web. 27 Feb 2021.

Vancouver:

Musmacker J. A Fast PCR Method for Rapid Identification of Infectious Pathogens . [Internet] [Thesis]. California State University – San Marcos; 2013. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10211.8/427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Musmacker J. A Fast PCR Method for Rapid Identification of Infectious Pathogens . [Thesis]. California State University – San Marcos; 2013. Available from: http://hdl.handle.net/10211.8/427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Valencia

19. Pallás Beneyto, Luis Alberto. Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico .

Degree: 2013, Universitat de Valencia

URL: http://hdl.handle.net/10550/34696

Establecer el valor pronóstico de niveles elevados en plasma de interleukina 6 en pacientes que ingresan en UCI con criterios de SIRS y sepsis en relación con la mortalidad y desarrollo de fracaso multiorgánico. Advisors/Committee Members: Sáiz Sánchez, María Carmen (advisor).

Subjects/Keywords: sepsis; interleukina 6

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APA (6^th Edition):

Pallás Beneyto, L. A. (2013). Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico . (Doctoral Dissertation). Universitat de Valencia. Retrieved from http://hdl.handle.net/10550/34696

Chicago Manual of Style (16^th Edition):

Pallás Beneyto, Luis Alberto. “Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico .” 2013. Doctoral Dissertation, Universitat de Valencia. Accessed February 27, 2021. http://hdl.handle.net/10550/34696.

MLA Handbook (7^th Edition):

Pallás Beneyto, Luis Alberto. “Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico .” 2013. Web. 27 Feb 2021.

Vancouver:

Pallás Beneyto LA. Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico . [Internet] [Doctoral dissertation]. Universitat de Valencia; 2013. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10550/34696.

Council of Science Editors:

Pallás Beneyto LA. Interleukina 6. Valor pronóstico de mortalidad y fracaso multiorgánico en el paciente crítico . [Doctoral Dissertation]. Universitat de Valencia; 2013. Available from: http://hdl.handle.net/10550/34696

Queens University

20. Samis, Andrew James Willis. Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model .

Degree: Biology, 2012, Queens University

URL: http://hdl.handle.net/1974/7193

► Sepsis-induced delayed gastric emptying is a significant clinical problem for patients in intensive care units worldwide. A series of studies were carried out to examine… (more)

▼ Sepsis-induced delayed gastric emptying is a significant clinical problem for patients in intensive care units worldwide. A series of studies were carried out to examine the nature and mechanisms of sepsis-induced delayed gastric emptying using a novel mouse model which used a standard food source and was devoid of upper gastrointestinal tract trauma and restraint. Using this model, lipopolysaccharide (LPS) injection produced a dose-dependent decrease in gastric emptying which onset by one hour. LPS produced an alteration in mouse behavior and piloerection at 30 minutes, increased resting respiratory rate at 3 hours, and did not impact body temperature. The onset of sepsis-induced delayed gastric emptying was closer to those centrally-mediated clinical signs of sepsis (altered behavior and piloerection) than to the peripherally-mediated clinical signs (respiratory rate) suggesting a central mechanism. C-Fos activation of the area postrema (AP), the nucleus of the solitary tract (NTS), and the dorsal motor nucleus of the vagus (DMV) was examined 30 minutes after LPS injection which is the onset time for sepsis-induced delayed gastric emptying. LPS exposure produced significantly more activated neurons in the AP and NTS, and less in the DMV. These results may suggest a central mechanism with the AP and NTS inhibiting the DMV. Examination of isolated strips of gastric antrum in a tissue bath showed a decreased contractile response to electrical field stimulation and carbachol after injection of LPS. This occurred at 18 hours post LPS injection, but not at 6 hours. Using the mouse model, sepsis-induced delayed gastric emptying was shown to be occurring at 6 hours when no difference in contractility was measurable suggesting intrinsic changes are not the cause. These studies suggest a new mechanistic paradigm for sepsis-induced delayed gastric emptying in which there is a biphasic response. This involves an initial rapid, centrally-mediated delay in gastric emptying occurring the first hour and followed by an intrinsic tissue-level response several hours later characterized by a decrease in gastric muscle contractility.

Subjects/Keywords: gastric emptying ; sepsis

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APA (6^th Edition):

Samis, A. J. W. (2012). Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Samis, Andrew James Willis. “Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model .” 2012. Thesis, Queens University. Accessed February 27, 2021. http://hdl.handle.net/1974/7193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Samis, Andrew James Willis. “Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model .” 2012. Web. 27 Feb 2021.

Vancouver:

Samis AJW. Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model . [Internet] [Thesis]. Queens University; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1974/7193.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Samis AJW. Timing and Mechanism of Sepsis-Induced Delayed Gastric Emptying in a Novel Mouse Model . [Thesis]. Queens University; 2012. Available from: http://hdl.handle.net/1974/7193

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Cuipal Alcalde, Juan Diego. Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015.

Degree: 2016, National University of San Marcos

URL: http://hdl.handle.net/20.500.12672/4679

► – Introduction: Early-onset neonatal sepsis is a clinical syndrome characterized by manifestations of systemic infection that appears in the first 72 hours of life, in… (more)

Subjects/Keywords: Sepsis neonatal temprana

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APA (6^th Edition):

Cuipal Alcalde, J. D. (2016). Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015. (Thesis). National University of San Marcos. Retrieved from http://hdl.handle.net/20.500.12672/4679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cuipal Alcalde, Juan Diego. “Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015.” 2016. Thesis, National University of San Marcos. Accessed February 27, 2021. http://hdl.handle.net/20.500.12672/4679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cuipal Alcalde, Juan Diego. “Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015.” 2016. Web. 27 Feb 2021.

Vancouver:

Cuipal Alcalde JD. Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015. [Internet] [Thesis]. National University of San Marcos; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/20.500.12672/4679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cuipal Alcalde JD. Características clínicas de la sepsis neonatal temprana en el Hospital Nacional Dos de Mayo, 2015. [Thesis]. National University of San Marcos; 2016. Available from: http://hdl.handle.net/20.500.12672/4679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Santos, Rui Pedro Lopes dos. Marcadores bioquímicos de sepsis.

Degree: 2014, Universidade Fernando Pessoa

URL: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489

►

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

A sepsis é uma… (more)

Subjects/Keywords: Sepsis; Biomarcadores; Infeção; Inflamação; Sepsis severa; Choque séptico; Sepsis; Biomarkers; Infection; Inflammation; Severe sepsis; Septic shock

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APA (6^th Edition):

Santos, R. P. L. d. (2014). Marcadores bioquímicos de sepsis. (Thesis). Universidade Fernando Pessoa. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santos, Rui Pedro Lopes dos. “Marcadores bioquímicos de sepsis.” 2014. Thesis, Universidade Fernando Pessoa. Accessed February 27, 2021. http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santos, Rui Pedro Lopes dos. “Marcadores bioquímicos de sepsis.” 2014. Web. 27 Feb 2021.

Vancouver:

Santos RPLd. Marcadores bioquímicos de sepsis. [Internet] [Thesis]. Universidade Fernando Pessoa; 2014. [cited 2021 Feb 27]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santos RPLd. Marcadores bioquímicos de sepsis. [Thesis]. Universidade Fernando Pessoa; 2014. Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/4489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

23. Chang, Dong Wook. Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis.

Degree: Clinical Research, 2014, UCLA

URL: http://www.escholarship.org/uc/item/83223909

► Background: Identifying factors associated with do-not-resuscitate (DNR) orders is an informative step in developing strategies to improve their use. As such, a descriptive analysis of… (more)

Subjects/Keywords: Medicine; Do-not-resuscitate; Sepsis

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APA (6^th Edition):

Chang, D. W. (2014). Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/83223909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chang, Dong Wook. “Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis.” 2014. Thesis, UCLA. Accessed February 27, 2021. http://www.escholarship.org/uc/item/83223909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chang, Dong Wook. “Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis.” 2014. Web. 27 Feb 2021.

Vancouver:

Chang DW. Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis. [Internet] [Thesis]. UCLA; 2014. [cited 2021 Feb 27]. Available from: http://www.escholarship.org/uc/item/83223909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chang DW. Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis. [Thesis]. UCLA; 2014. Available from: http://www.escholarship.org/uc/item/83223909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

24. Rochwerg, Bram. RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL.

Degree: MSc, 2015, McMaster University

URL: http://hdl.handle.net/11375/18139

►

This thesis consists of two related studies presented as three separate manuscripts (all three have been published in peer-reviewed journals) and a study protocol that… (more)

▼

This thesis consists of two related studies presented as three separate manuscripts (all three have been published in peer-reviewed journals) and a study protocol that has been submitted for peer-reviewed funding. The over-arching theme of this thesis was to better characterize the efficacy of different intravenous fluids used for the resuscitation of intensive care unit (ICU) patients with severe sepsis or septic shock. We performed an extensive search including multiple databases which found 20 randomized controlled trials (RCTs) that examined the effects of different intravenous fluids used in septic patients and met our a priori inclusion and exclusion criteria. In the first manuscript, we described in detail the composition of the 19 unique fluid products that were used in the various studies. This description included the fluid type, trade name, osmolality, tonicity, electrolyte content, molecular composition, pH, and manufacturer. We reviewed manufacturer’s websites, product monographs, and emailed industry representatives or study authors for more information regarding the fluids as required. The results of this study and systematic review led us to the second and third manuscripts which reported on a Bayesian network meta-analysis (NMA) of all fluid type comparisons. Despite multiple well-done RCTs, comparative data regarding the clinical effect of different resuscitative fluids when used for sepsis was incomplete. Most RCTs used 0.9% saline (normal saline) as control fluid and very few studies compared colloids directly. The advantage of using an NMA model in this setting was the ability to include indirect data into the overall point estimates. Data was abstracted from the 14 studies which focused on adult ICU patients and analyzed examining the outcomes of mortality (manuscript2) and the use of renal replacement therapy (RRT) (manuscript #3). Certainty of evidence was evaluated for both outcomes using the GRADE approach. Results of the analysis clearly document the harm of starch-based fluids when used in septic patients. Albumin containing fluids and crystalloids (such as normal saline and Ringer’s Lactate) are better options. Lower chloride solutions, such as Ringer’s Lactate, showed a signal towards decreased mortality and a decreased use of renal replacement therapy when compared to higher chloride fluids, such as normal saline, however this was based on indirect data, not statistically significant, and warrants direct comparison trials. The final component of this thesis is a pilot study protocol for a study assessing the feasibility of a larger RCT examining the effect of low chloride versus high chloride fluids for resuscitation in patients with sepsis and septic shock. This protocol has been submitted as part of a peer-reviewed grant with the hopes of addressing this clinically important and timely question.

Thesis

Master of Science (MSc)

This thesis examines the ideal intravenous fluid to be given to patients with severe infection causing low blood pressure. A review of…

Advisors/Committee Members: Brozek, Jan, Guyatt, Gordon, Jaeschke, Roman, Health Research Methodology.

Subjects/Keywords: sepsis; network meta-analysis; fluids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rochwerg, B. (2015). RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18139

Chicago Manual of Style (16^th Edition):

Rochwerg, Bram. “RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL.” 2015. Masters Thesis, McMaster University. Accessed February 27, 2021. http://hdl.handle.net/11375/18139.

MLA Handbook (7^th Edition):

Rochwerg, Bram. “RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL.” 2015. Web. 27 Feb 2021.

Vancouver:

Rochwerg B. RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL. [Internet] [Masters thesis]. McMaster University; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11375/18139.

Council of Science Editors:

Rochwerg B. RESUSCITATIVE FLUIDS IN SEPSIS AND SEPTIC SHOCK: A SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND PILOT STUDY PROTOCOL. [Masters Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/18139

Harvard University

25. Flores, Julian. Risk of Prolonged Intensive Care Length of Stay Relative to Extent of Fluid Resuscitation and Time to Vasopressor Initiation in Pediatric Sepsis.

Degree: Doctor of Medicine, 2016, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620270

►

Purpose: Septic shock continues to be a leading causes of pediatric mortality worldwide. Currently there is only limited literature detailing what constellation of signs and… (more)

▼

Purpose: Septic shock continues to be a leading causes of pediatric mortality worldwide. Currently there is only limited literature detailing what constellation of signs and symptoms may predict children with septic shock. In particular, there is scant literature on whether excessive fluid resuscitation (> 60 mL/kg) following a diagnosis of hypotension or if delays in vasopressor initiation following fluid-refractory septic shock lead to worse outcomes. I hypothesize that in children in the ED with septic shock, greater amounts of fluids and the time to vasopressor initiation after last fluid bolus is associated with worse outcomes. Methods: This project is part of a larger retrospective, time series study describing baseline data for quality of care metrics in the diagnosis and management of pediatric septic shock. Children 0-18 years of age were eligible for the study if they presented to the ED from November 2012 to December 2014 with signs and symptoms concerning for sepsis and had hypotension for age during their ED course. Predictors of outcomes were total volume of fluid in milliliters per kilogram received in the ED following hypotension and time to vasopressor initiation following determination of time of fluid-refractory shock. Outcomes of mortality, total hospital length of stay, intensive care length of stay, and duration of vasopressors were assessed. Outcomes were controlled for potential confounders of age and severity of illness using the Pediatric Risk of Mortality score III. Results: 408 patients underwent analysis. 220 (53.9%) were males (95% Confidence Interval: 49.0%-58.7%). Fluid administration of more than 60 mL/kg in the ED was not associated with worsened mortality, intensive care or hospital length of stay, or longer vasopressor requirement. After controlling for severity of illness and age, the intensive care length of stay and duration of vasopressor support was statistically longer (p value = .045 and 0.008, respectively). Specifically, for every minute of vasopressor delay, intensive care length of stay and duration of time spent on vasopressor support increased by 19 and 13 minutes, respectively (p<.05). Conclusions: Delays in vasopressor initiation from fluid refractory shock is associated with an increased intensive care length of stay and longer time on vasopressors. These results call for the exploration of interventions that can improve timeliness of vasopressor initiation.

Scholarly Project

Subjects/Keywords: pediatric; sepsis; fluids; vasopressors

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APA (6^th Edition):

Flores, J. (2016). Risk of Prolonged Intensive Care Length of Stay Relative to Extent of Fluid Resuscitation and Time to Vasopressor Initiation in Pediatric Sepsis. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620270

Chicago Manual of Style (16^th Edition):

Flores, Julian. “Risk of Prolonged Intensive Care Length of Stay Relative to Extent of Fluid Resuscitation and Time to Vasopressor Initiation in Pediatric Sepsis.” 2016. Doctoral Dissertation, Harvard University. Accessed February 27, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620270.

MLA Handbook (7^th Edition):

Flores, Julian. “Risk of Prolonged Intensive Care Length of Stay Relative to Extent of Fluid Resuscitation and Time to Vasopressor Initiation in Pediatric Sepsis.” 2016. Web. 27 Feb 2021.

Vancouver:

Flores J. Risk of Prolonged Intensive Care Length of Stay Relative to Extent of Fluid Resuscitation and Time to Vasopressor Initiation in Pediatric Sepsis. [Internet] [Doctoral dissertation]. Harvard University; 2016. [cited 2021 Feb 27]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620270.

Council of Science Editors:

Flores J. Risk of Prolonged Intensive Care Length of Stay Relative to Extent of Fluid Resuscitation and Time to Vasopressor Initiation in Pediatric Sepsis. [Doctoral Dissertation]. Harvard University; 2016. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620270

Karlstad University

26. Johansson, Sandra. Faktorer som påverkar sjuksköterskors identifiering av sepsis : En litteraturstudie.

Degree: Science and Technology (starting 2013), 2020, Karlstad University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-77652

► Bakgrund: Sepsis är ett globalt hälsoproblem med oacceptabelt hög mortalitet. Som omvårdnadsansvarig har sjuksköterskan ett viktigt arbete i att identifiera patienten med sepsis för… (more)

Subjects/Keywords: Sepsis; Identifiering; Sjuksköterska; Nursing; Omvårdnad

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APA (6^th Edition):

Johansson, S. (2020). Faktorer som påverkar sjuksköterskors identifiering av sepsis : En litteraturstudie. (Thesis). Karlstad University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-77652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Johansson, Sandra. “Faktorer som påverkar sjuksköterskors identifiering av sepsis : En litteraturstudie.” 2020. Thesis, Karlstad University. Accessed February 27, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-77652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Johansson, Sandra. “Faktorer som påverkar sjuksköterskors identifiering av sepsis : En litteraturstudie.” 2020. Web. 27 Feb 2021.

Vancouver:

Johansson S. Faktorer som påverkar sjuksköterskors identifiering av sepsis : En litteraturstudie. [Internet] [Thesis]. Karlstad University; 2020. [cited 2021 Feb 27]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-77652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Johansson S. Faktorer som påverkar sjuksköterskors identifiering av sepsis : En litteraturstudie. [Thesis]. Karlstad University; 2020. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-77652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

27. Nazari, Shekufah. Neutrophil killing of Staphylococcus aureus In Sepsis .

Degree: University of Otago

URL: http://hdl.handle.net/10523/7509

► Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms… (more)

▼ Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms into a phagosome where they kill them using reactive oxygen species and a range of antimicrobial proteins. Sepsis is described as a complicated clinical disorder that is generated from a dangerous host response to an infection. One of the main organisms responsible for causing infection in sepsis is Staphylococcus aureus. Pro-inflammatory cytokines are elevated in patients with sepsis. These cytokines are also known to prime neutrophils and as a result, superoxide production is elevated in neutrophils. This may help to destroy the pathogen more rapidly. The main aim of this study was to compare the ability of neutrophils to kill S. aureus in serum from healthy individuals to that in serum rich in inflammatory cytokines obtained from sepsis patients. To test the priming effect of sepsis serum, neutrophils were pre-incubated in either healthy or sepsis serum followed by stimulation with Formyl-methionyl-leucyl-phenylalanine. Cells incubated in sepsis serum followed by stimulation showed significantly increased superoxide production compared to cells incubated in healthy serum. S. aureus were pre-treated in either serum collected from healthy donors or serum from patients with sepsis and then incubated with neutrophils. A one-step neutrophil killing assay was used which gave the combined rate of phagocytosis and killing. I found that there was no significant differences in the rate of phagocytosis and killing of S. aureus by neutrophils in healthy and sepsis serum. Since neutrophils kill S. aureus mainly by an oxidative mechanism, the effect of diphenylene iodonium, an inhibitor of flavoproteins such as NADPH oxidase, was checked to see if there was any difference in the mechanism of killing in sepsis serum. I found that the contribution of NADPH oxidase derived oxidants to killing was similar in healthy or sepsis serum. S. aureus have adapted many protective mechanisms in order to avoid being destroyed by neutrophils. A two-step killing assay that separate rates of killing and phagocytosis, was used to assess whether S. aureus collected from patients after antibiotic treatment were more resistant to neutrophil killing. The result showed no difference in the rate of neutrophil phagocytosis and killing of clinical isolates compared to the lab strain of S. aureus. Hypochlorous acid is a powerful oxidant used by neutrophils to kill invading microorganisms. It is known that S. aureus can survive within neutrophil, despite exposure to hypochlorous acid potentially by upregulation of survival genes. Pretreatment of S. aureus with a sub-lethal dose of hypochlorous acid did not protect bacteria from a subsequent dose of hypochlous acid. In conclusion I have tested neutrophil killing of S. aureus in normal healthy serum and serum from sepsis patients. The results show that even though there was increased superoxide production by… Advisors/Committee Members: Winterbourn, Christine (advisor).

Subjects/Keywords: Neutrophils; Sepsis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nazari, S. (n.d.). Neutrophil killing of Staphylococcus aureus In Sepsis . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/7509

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Nazari, Shekufah. “Neutrophil killing of Staphylococcus aureus In Sepsis .” Masters Thesis, University of Otago. Accessed February 27, 2021. http://hdl.handle.net/10523/7509.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Nazari, Shekufah. “Neutrophil killing of Staphylococcus aureus In Sepsis .” Web. 27 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Nazari S. Neutrophil killing of Staphylococcus aureus In Sepsis . [Internet] [Masters thesis]. University of Otago; [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10523/7509.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Nazari S. Neutrophil killing of Staphylococcus aureus In Sepsis . [Masters Thesis]. University of Otago; Available from: http://hdl.handle.net/10523/7509

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Tampere University

28. Tikkanen, Ville. Sepsiksen tunnistaminen ensihoidossa .

Degree: 2018, Tampere University

URL: https://trepo.tuni.fi/handle/10024/104562

► Sepsis määritellään tilaksi, jossa infektio on aiheuttanut potilaalle elinhäiriön ja sen myötä kasvaneen kuolemanriskin. Sepsistä hoidetaan laajakirjoisella suonensisäisellä antibiootilla ja antibioottihoidon aloituksen viivästyminen on suurin… (more)

▼ Sepsis määritellään tilaksi, jossa infektio on aiheuttanut potilaalle elinhäiriön ja sen myötä kasvaneen kuolemanriskin. Sepsistä hoidetaan laajakirjoisella suonensisäisellä antibiootilla ja antibioottihoidon aloituksen viivästyminen on suurin yksittäinen kuolleisuuteen vaikuttava tekijä. Sepsiksen ja elinhäiriön tunnistamiseksi tehohoidon ulkopuolella on kehitetty quickSOFA-pisteytys (qSOFA), jossa potilaalta mitataan hengitystiheys, systolinen verenpaine ja tajunnan taso GCS-asteikolla. Jos potilaalla epäillään infektiota, ja qSOFA on positiivinen, tulee määritelmän mukaan epäillä sepsistä. Tutkimuksen tavoitteena oli selvittää, auttaisiko qSOFA:n käyttö ensihoidossa tunnistamaan sepsispotilaat. Lisäksi arvioimme, kuinka paljon aikaisemmin olisi mahdollista annostella antibiootti, jos ensihoitajilla olisi konsultaatioon perustuen tähän mahdollisuus, ja tulisiko näin toimien annettua antibioottia potilaille, joilla ei ole sepsistä tai infektiota. Tutkimusaineistoon kuuluivat kaikki Pirkanmaan sairaanhoitopiirin ensihoitopalvelun Acutaan kuljettamat potilaat aikavälillä 23.6.—1.7.2015. Tutkimusviikon aikana Acutaan kuljetettiin 493 potilasta. Ensihoitajat mittasivat potilailta hengitystaajuuden, verenpaineen, tajunnan tason ja lämmön, ja näistä laskettiin jokaiselle qSOFA-pisteet. Aineistoa täydennettiin hälytyskeskuksen tehtäväkohtaisilla tiedoilla, Acutan hoitosuunnitelmakaavakkeilla sekä potilastietojärjestelmä Mirandan tiedoilla, joista tarkastettiin, oliko potilaalle annettu antibioottihoitoa ensiavussa. qSOFA-positiivisia potilaita oli yhden viikon aineistossamme yhteensä 13 (2,6 %). Sepsispotilaita oli yhteensä viisi, joista qSOFA-positiivisia oli kolme. qSOFA saavutti 60 % herkkyyden ja 98 % tarkkuuden sepsiksen tunnistamisessa. qSOFA yhdistettynä epänormaaliin ruumiinlämpöön (>38 ̊C tai <36 ̊C) saavutti 60 % herkkyyden ja 99 % tarkkuuden sepsiksen tunnistamisessa. Tällä menetelmällä antibioottihoito olisi ensihoidossa aloitettu kuudelle potilaalle, joista kolmella oli sepsis ja kolmella muu infektio. Virheellisiä antibioottihoitoja ei olisi aloitettu yhtään. Antibioottihoito olisi kolmella sepsispotilaalla aikaistunut noin kaksi tuntia. Positiivinen qSOFA ennusti myös moninkertaista tehohoitoon päätymisen riskiä. Aineistossa oli 480 qSOFA-negatiivista potilasta, joista kahdella oli sepsis. qSOFA yhdistettynä epänormaaliin lämpöön on käyttökelpoinen työkalu sepsispotilaiden tunnistamisen tueksi ensihoidossa. Toimintamallia voisi harkita käytettäväksi myös Pirkanmaan sairaanhoitopiirin ensihoidossa. On muistettava, että qSOFA on vain yksi osa sepsiksen hoidon aloittamisessa. Tärkein tekijä on infektion oikea-aikainen epäily ensihoitajien toimesta. Tämän opinnäytteen alkuperäisyys on tarkastettu Turnitin OriginalityCheck-ohjelmalla Tampereen yliopiston laatujärjestelmän mukaisesti.

Subjects/Keywords: sepsis; quickSOFA; SOFA; emergency medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tikkanen, V. (2018). Sepsiksen tunnistaminen ensihoidossa . (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/104562

Chicago Manual of Style (16^th Edition):

Tikkanen, Ville. “Sepsiksen tunnistaminen ensihoidossa .” 2018. Masters Thesis, Tampere University. Accessed February 27, 2021. https://trepo.tuni.fi/handle/10024/104562.

MLA Handbook (7^th Edition):

Tikkanen, Ville. “Sepsiksen tunnistaminen ensihoidossa .” 2018. Web. 27 Feb 2021.

Vancouver:

Tikkanen V. Sepsiksen tunnistaminen ensihoidossa . [Internet] [Masters thesis]. Tampere University; 2018. [cited 2021 Feb 27]. Available from: https://trepo.tuni.fi/handle/10024/104562.

Council of Science Editors:

Tikkanen V. Sepsiksen tunnistaminen ensihoidossa . [Masters Thesis]. Tampere University; 2018. Available from: https://trepo.tuni.fi/handle/10024/104562

Tampere University

29. Ranta, Noora. The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study .

Degree: 2016, Tampere University

URL: https://trepo.tuni.fi/handle/10024/98637

► Infektiotaudit ovat tavallinen ongelma päivystysklinikalla. Erityisesti sepsiksen diagnosointi on hankalaa, sillä taudille ei tällä hetkellä ole olemassa sopivaa biomarkkeria. Sepsis on melko yleinen, nopeasti etenevä… (more)

▼ Infektiotaudit ovat tavallinen ongelma päivystysklinikalla. Erityisesti sepsiksen diagnosointi on hankalaa, sillä taudille ei tällä hetkellä ole olemassa sopivaa biomarkkeria. Sepsis on melko yleinen, nopeasti etenevä systeeminen infektio, johon liittyy merkittävän suuri kuolleisuus. Jo parissa päivässä oireiden alkamisesta kehittyvään vakavaan sepsikseen menehtyy noin 70 % potilaista. Tämän vuoksi varhaisen vaiheen diagnostiikka ja nopea, tehokkaan mikrobilääkehoidon aloitus ovat elintärkeitä sepsispotilaille. Biomarkkerin puuttumisen vuoksi hoidon aloitus viivästyy ja potilaan ennuste heikkenee. Aiemmissa tutkimuksissa on havaittu elimistössä laaja-alaisesti esiintyvän proproteiini konvertaasi furiinin yhteys monenlaisiin tulehdustiloihin. Furiini on proteaasientsyymi, joka säätelee muun muassa T auttaja 1 -solujen aktiivisuutta sekä TLR7 reseptorien määrää. Lisäksi lipopolysakkaridi (LPS) lisää sen ilmentymistä makrofageissa. Tutkimuksen tavoitteena on selvittää voitaisiinko päivystyksessä potilaiden plasmanäytteistä mitattuja furiinipitoisuuksia käyttää hyväksi infektion varhaisen vaiheen diagnostiikassa, vakavuuden arvioinnissa, kuolleisuuden ennustamisessa ja/tai oikeanlaisen antibioottihoidon valitsemisessa. Potilasaineisto kerättiin Satakunnan keskussairaalasta vuosina 2004 ja 2005. Se koostuu täysi-ikäisistä, päivystyspoliklinikalle saapuneista infektioepäilypotilaista. Verinäytteet kerättiin päivystyksessä ja muu data haastattelusta ja sairaskertomuksista. Plasman furiinipitoisuus määritettiin kaupallisella ELISA-menetelmällä (Human Furin Enzyme Linked Immunosorbent Assay, Sigma-Aldrich®) ja tulokset jaettiin korkean ja matalan pitoisuuden ryhmiin. Myös potilaat jaoteltiin infektiotyypin perusteella viiteen diagnostiseen ryhmään. Tilastolliset analyysit suoritettiin SPSS-ohjelmalla (IBM, versio 22). Tilastollisesti merkitsevää yhteyttä ei havaittu verrattaessa sepsiksen yleisyyttä (P = 0,421), diagnostista ryhmää (P = 0,737) sekä veriviljelyn tulosta (P = 0,351) potilaan furiinitasoon. Furiinipitoisuus ja kuolleisuus eivät myöskään liittyneet toisiinsa (P = 0,898). Merkitsevät korrelaatiot löydettiin korkean furiinitason ja tupakoimattomuuden (P = 0,034) sekä reumasairauksien (P < 0,001) väliltä. Furiini ei sovellu infektiomarkkeriksi päivystyspoliklinikalla eikä sen plasmapitoisuudesta voida tehdä johtopäätöksiä liittyen taudin vakavuuteen tai potilaan ennusteeseen. Pitoisuuksien määrittämisestä ei myöskään ole apua oikean mikrobilääkkeen valinnassa. Toisaalta, furiinitasojen jakautumista olisi jatkossa mielenkiintoista tutkia erityisesti reumapotilaista koostuvassa aineistossa.

Subjects/Keywords: biomarkkeri; SIRS; sepsis; tapauskuolleisuus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ranta, N. (2016). The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study . (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/98637

Chicago Manual of Style (16^th Edition):

Ranta, Noora. “The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study .” 2016. Masters Thesis, Tampere University. Accessed February 27, 2021. https://trepo.tuni.fi/handle/10024/98637.

MLA Handbook (7^th Edition):

Ranta, Noora. “The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study .” 2016. Web. 27 Feb 2021.

Vancouver:

Ranta N. The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study . [Internet] [Masters thesis]. Tampere University; 2016. [cited 2021 Feb 27]. Available from: https://trepo.tuni.fi/handle/10024/98637.

Council of Science Editors:

Ranta N. The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study . [Masters Thesis]. Tampere University; 2016. Available from: https://trepo.tuni.fi/handle/10024/98637

University of Debrecen

30. Mercier, Matthew Denis. Concerning the role of hemorheological and microcirculatory changes in the pathophysiology of sepsis .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194733

Review of the pathophysiology, microcirculation and animal models in sepsis. Advisors/Committee Members: Németh, Norbert (advisor), Debreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet::Sebészeti M?téttani Tanszék (advisor).

Subjects/Keywords: Microcirculation; Sepsis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mercier, M. D. (2014). Concerning the role of hemorheological and microcirculatory changes in the pathophysiology of sepsis . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mercier, Matthew Denis. “Concerning the role of hemorheological and microcirculatory changes in the pathophysiology of sepsis .” 2014. Thesis, University of Debrecen. Accessed February 27, 2021. http://hdl.handle.net/2437/194733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mercier, Matthew Denis. “Concerning the role of hemorheological and microcirculatory changes in the pathophysiology of sepsis .” 2014. Web. 27 Feb 2021.

Vancouver:

Mercier MD. Concerning the role of hemorheological and microcirculatory changes in the pathophysiology of sepsis . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2437/194733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mercier MD. Concerning the role of hemorheological and microcirculatory changes in the pathophysiology of sepsis . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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