subject:(Selenium)

Oregon State University

1. Stewart, Whitney C. Effect of selenium source and supplementation rate in ewes on selenium status, passive immunity and growth performance of their lambs.

Degree: MS, Animal Science, 2010, Oregon State University

URL: http://hdl.handle.net/1957/19488

► Selenium (Se) is an essential micronutrient of sheep. Supplementation is especially important in young lambs in order to prevent Se-deficiency signs. In the United States,… (more)

▼ Selenium (Se) is an essential micronutrient of sheep. Supplementation is especially important in young lambs in order to prevent Se-deficiency signs. In the United States, the FDA regulates Se supplementation to ruminant diets at a level of 0.3 mg/kg Se (as fed basis). Questions still exist regarding what chemical form of Se is the most bioavailable supplement and what are the best supplementation rates for optimal productivity. Three interrelated experiments from the same study were conducted 1) to evaluate the effect of Se source and supplementation rate in ewes on Se status of their lambs at birth, 2) to examine the effect of Se source and supplementation rate on IgG concentrations in ewe colostrum and lamb serum, and 3) to evaluate the effects of Se source and supplementation rate on ewe reproductive performance and subsequent vitality and growth performance of their lambs. For these experiments, 240 ewes were divided into 8 treatment groups and drenched weekly (at an amount equal to their summed daily intake) for one year, including during gestation and early lactation, with no Se (deficient); at recommended levels (0.3 mg/kg) with inorganic sodium selenite, sodium selenate, or organic Se-yeast (Se-Y); or at supranutritional levels (0.9 and 1.5 mg/kg) with sodium selenite or Se yeast. In the third experiment, 88 ewes continued the study into year two for an additional 28 weeks. Year two treatments included no Se (deficient) ewes (n = 25); ewes supplemented at recommended levels (0.3 mg/kg) with organic Se-Y (n = 20); ewes supplemented at supranutritional levels (0.9 and 1.5 mg/kg) with organic Se-Y (n = 18 and 27, respectively). In the first experiment, which assessed the effects of Se source and supplementation rate in ewes on Se status of their offspring, we found that Se administered by weekly drenching of ewes during gestation and early lactation was effective at increasing Se concentrations in ewe colostrum and milk at 30 days in milk (DIM), and in improving the Se status of lambs (whole-blood and serum Se at birth, and skeletal-muscle Se at 14 days of age) (all P < 0.001). Selenium concentrations in lacteal secretions and lambs were higher in ewes drenched with Se yeast compared to ewes drenched with inorganic Se sources (P < 0.01). Selenium concentrations in lacteal secretions and in lambs increased linearly with supranutritional concentrations of Se yeast (P < 0.001), whereas Se concentrations did not differ in ewes drenched with 0.9 or 1.5 mg/kg of inorganic sodium selenite (P > 0.05). In summary, weekly oral drenching of ewes with Se yeast during gestation and early lactation was found to be an effective method for improving Se status of their newborn lambs. In the second experiment, which examined the effects of Se source and supplementation rate in ewes on colostral IgG and lamb serum-IgG concentrations, we measured colostral and lamb serum-IgG concentrations at parturition, and lamb serum-IgG concentration again at 48 hours postnatal. Although Se drenching of ewes was effective at increasing… Advisors/Committee Members: Hall, Jean (advisor).

Subjects/Keywords: selenium

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APA (6^th Edition):

Stewart, W. C. (2010). Effect of selenium source and supplementation rate in ewes on selenium status, passive immunity and growth performance of their lambs. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/19488

Chicago Manual of Style (16^th Edition):

Stewart, Whitney C. “Effect of selenium source and supplementation rate in ewes on selenium status, passive immunity and growth performance of their lambs.” 2010. Masters Thesis, Oregon State University. Accessed June 19, 2019. http://hdl.handle.net/1957/19488.

MLA Handbook (7^th Edition):

Stewart, Whitney C. “Effect of selenium source and supplementation rate in ewes on selenium status, passive immunity and growth performance of their lambs.” 2010. Web. 19 Jun 2019.

Vancouver:

Stewart WC. Effect of selenium source and supplementation rate in ewes on selenium status, passive immunity and growth performance of their lambs. [Internet] [Masters thesis]. Oregon State University; 2010. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1957/19488.

Council of Science Editors:

Stewart WC. Effect of selenium source and supplementation rate in ewes on selenium status, passive immunity and growth performance of their lambs. [Masters Thesis]. Oregon State University; 2010. Available from: http://hdl.handle.net/1957/19488

Queens University

2. Hnain, Antoine. The Synthesis of Elemental Selenium Particles by the Cyanobacterium Synechococcus leopoliensis .

Degree: Biology, 2012, Queens University

URL: http://hdl.handle.net/1974/7481

► In the present study the light dependent biosynthesis of spherical red elemental selenium Se(0) granules (average size of 220 nm) by the cyanobacterium Synechococcus leopoliensis… (more)

Subjects/Keywords: Selenium; Microbiology

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APA (6^th Edition):

Hnain, A. (2012). The Synthesis of Elemental Selenium Particles by the Cyanobacterium Synechococcus leopoliensis . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7481

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hnain, Antoine. “The Synthesis of Elemental Selenium Particles by the Cyanobacterium Synechococcus leopoliensis .” 2012. Thesis, Queens University. Accessed June 19, 2019. http://hdl.handle.net/1974/7481.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hnain, Antoine. “The Synthesis of Elemental Selenium Particles by the Cyanobacterium Synechococcus leopoliensis .” 2012. Web. 19 Jun 2019.

Vancouver:

Hnain A. The Synthesis of Elemental Selenium Particles by the Cyanobacterium Synechococcus leopoliensis . [Internet] [Thesis]. Queens University; 2012. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1974/7481.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hnain A. The Synthesis of Elemental Selenium Particles by the Cyanobacterium Synechococcus leopoliensis . [Thesis]. Queens University; 2012. Available from: http://hdl.handle.net/1974/7481

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

3. Alabi, Nathaniel Sigismund. Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies.

Degree: PhD, Animal Science, 1983, Oregon State University

URL: http://hdl.handle.net/1957/41315

► Studies were conducted to investigate the metabolism of selenium (Se) , and the influences of Se on the metabolism of cadmium (Cd) and inorganic mercury… (more)

▼ Studies were conducted to investigate the metabolism of selenium (Se) , and the influences of Se on the metabolism of cadmium (Cd) and inorganic mercury (Hg) in rats, and in ram semen in vitro. Se-deficient (-Se) or Se-adequate (+Se) rats were injected intraperitoneally with either ¹⁰⁹CdCl₂ (5 μCi/rat) or ²⁰³HgN0₃ (10 μCi/rat). Semen ejaculates from yearling Suffolk rams were used for the in vitro studies. Whole-body retention of Cd and Hg in rats was significantly (P < 0.05) increased by Se. However, regardless of the Se status, the predominant route of Cd and Hg excretion was feces. Data on whole tissue Cd retention for both -Se and +Se rats gave the following order of decreasing tissue Cd levels: liver > kidney > testis > epididymis > seminal vesicles > prostate > brain. Hg distribution in tissues followed a similar order except that Hg concentrations were highest in kidney. Se caused a significant redistribution of Cd and Hg among the cytosolic proteins in some tissues (e.g., testis) but not in others like brain and prostate gland. Such diversions were usually from low (10,000 - 30,000) molecular weight (MW) proteins to higher (>70,000) MW ones. Ram sperm incorporated small amounts of Cd and Hg in vitro. A non-thionein metal-binding protein (MW = 10,000) was purified from the spermatozoa, and found to contain low amounts of cysteine and some aromatic amino acids (phenylalanine and tyrosine). Evidence was obtained which suggests that spermatozoa from rats and rams are capable of converting inorganic Se (as selenite) into selenoamino acids both in vivo and in vi tro. Amino acid analyses of sperm hydrolysates showed that selenocystine and selenomethio nine were respectively the major chemical forms of Se in rat and ram spermatozoa. Cd and Hg concentrations ranging from 10⁻⁶ to 10⁻² M were shown to be injurious to ram sperm in vitro as indicated by the depressed motility and reduced oxygen uptake. Equimolar concentrations of Se as selenite, selenocystine or selenomethionine counteracted the toxicity of Cd or Hg at low concentrations (10⁻⁵ to 10⁻⁶ M). Incubation of ram spermatozoa with concentrations of Se ranging from 0.08 to 2.0 ppm markedly improved sperm motility and oxygen consumption. Advisors/Committee Members: Whanger, Philip D. (advisor), Horton, Howard (committee member).

Subjects/Keywords: Selenium

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APA (6^th Edition):

Alabi, N. S. (1983). Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/41315

Chicago Manual of Style (16^th Edition):

Alabi, Nathaniel Sigismund. “Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies.” 1983. Doctoral Dissertation, Oregon State University. Accessed June 19, 2019. http://hdl.handle.net/1957/41315.

MLA Handbook (7^th Edition):

Alabi, Nathaniel Sigismund. “Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies.” 1983. Web. 19 Jun 2019.

Vancouver:

Alabi NS. Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies. [Internet] [Doctoral dissertation]. Oregon State University; 1983. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1957/41315.

Council of Science Editors:

Alabi NS. Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies. [Doctoral Dissertation]. Oregon State University; 1983. Available from: http://hdl.handle.net/1957/41315

Oregon State University

4. Alabi, Nathaniel Sigismund. Glutathione peroxidase and selenium distribution in semen and reproductive tissues of farm animals.

Degree: MS, Animal Science, 1981, Oregon State University

URL: http://hdl.handle.net/1957/42194

► This study was conducted to investigate the distribution of glutathione peroxidase (GSH-Px) and selenium in semen of the boar, bull, ram and stallion, and in… (more)

▼ This study was conducted to investigate the distribution of glutathione peroxidase (GSH-Px) and selenium in semen of the boar, bull, ram and stallion, and in the reproductive tissues of the boar, bull and ram. The effect of repeated noncryoprotective freeze-thawing on GSH-Px activity was also studied. Both hydrogen peroxide (H₂0₂) and tetra-butyl hydroperoxide (t-butyl 0₂) were used as substrates for the enzyme. Most of the GSH-Px activity in semen of the four species examined was associated with seminal plasma. GSH-Px activities in the spermatozoa of these species were comparatively very low. There were species and tissue differences in the distribution of GSH-Px in reproductive tissues. Determined per mg protein, GSH-Px activity was highest in the testis, whereas the Cowper's gland and ampulla showed the least enzyme activity. In general, GSH-Px levels in the reproductive tissues of the bull were higher than, or comparable to, those of the ram. The reproductive tissues of the boar showed the least GSH-Px activity. The GSH-Px determined in this study showed a similar magnitude of response to both H₂0₂ and t-butyl 0₂ and had a high correlation with tissue and fluid selenium levels. This demonstrates that the GSH-Px found in semen and reproductive tissues of the boar, bull and ram is a selenium-dependent enzyme. Repeated freezing (at -21°C) and thawing, in the absence of appropriate buffers, led to a decline in seminal plasma and reproductive tissue GSH-Px activities. Selenium distribution in semen and reproductive tissues differed among the species studies. On the basis of selenium concentration per billion sperm cells, boar spermatozoa had the highest selenium concentration followed by those of the stallion, bull and ram in that order. Bull seminal plasma, however, had more selenium than that of any of the other three species. The testis and epididymis had the greatest concentration of selenium found in the reproductive tissues. Levels of selenium in semen and reproductive tissues were significantly higher (P<0.05) than those in blood. The implications of these findings, as well as the inter-relationship between selenium, GSH-Px and animal reproduction, are discussed. Advisors/Committee Members: Wu, Arthur S. (advisor), Oldfield, James E. (committee member).

Subjects/Keywords: Selenium

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APA (6^th Edition):

Alabi, N. S. (1981). Glutathione peroxidase and selenium distribution in semen and reproductive tissues of farm animals. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/42194

Chicago Manual of Style (16^th Edition):

Alabi, Nathaniel Sigismund. “Glutathione peroxidase and selenium distribution in semen and reproductive tissues of farm animals.” 1981. Masters Thesis, Oregon State University. Accessed June 19, 2019. http://hdl.handle.net/1957/42194.

MLA Handbook (7^th Edition):

Alabi, Nathaniel Sigismund. “Glutathione peroxidase and selenium distribution in semen and reproductive tissues of farm animals.” 1981. Web. 19 Jun 2019.

Vancouver:

Alabi NS. Glutathione peroxidase and selenium distribution in semen and reproductive tissues of farm animals. [Internet] [Masters thesis]. Oregon State University; 1981. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1957/42194.

Council of Science Editors:

Alabi NS. Glutathione peroxidase and selenium distribution in semen and reproductive tissues of farm animals. [Masters Thesis]. Oregon State University; 1981. Available from: http://hdl.handle.net/1957/42194

University of Debrecen

5. Juhos, Anita. Tesztelési módszertanok .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Matematikai Intézet, 2013, University of Debrecen

URL: http://hdl.handle.net/2437/170596

► Magyarországon ez időben kezd elterjedni a tesztelés, egyre több cég ismeri fel, hogy a magasabb színvonalú, jobb szoftverek létrehozásához és fenntartásához, fejlesztéséhez elengedhetetlen a tesztelés.… (more)

Subjects/Keywords: tesztelés; selenium

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APA (6^th Edition):

Juhos, A. (2013). Tesztelési módszertanok . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/170596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Juhos, Anita. “Tesztelési módszertanok .” 2013. Thesis, University of Debrecen. Accessed June 19, 2019. http://hdl.handle.net/2437/170596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Juhos, Anita. “Tesztelési módszertanok .” 2013. Web. 19 Jun 2019.

Vancouver:

Juhos A. Tesztelési módszertanok . [Internet] [Thesis]. University of Debrecen; 2013. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2437/170596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Juhos A. Tesztelési módszertanok . [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/170596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

6. Khan, Rana. Structural studies of Halogen, Interhalogen and Pseudohalogen Compounds of Phosphorus, Selenium and Tellurium.

Degree: 2011, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:123912

► A series of compounds with the general formula R3PX2 and R3PX4 (where R = o-tolyl, m-tolyl, p-tolyl, o-anisyl, m-anisyl, p-anisyl, o-thioanisyl, p-thioanisyl, p-fluorophenyl, p-chlorophenyl, mesityl… (more)

Subjects/Keywords: Selenium; Phosphorus

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APA (6^th Edition):

Khan, R. (2011). Structural studies of Halogen, Interhalogen and Pseudohalogen Compounds of Phosphorus, Selenium and Tellurium. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:123912

Chicago Manual of Style (16^th Edition):

Khan, Rana. “Structural studies of Halogen, Interhalogen and Pseudohalogen Compounds of Phosphorus, Selenium and Tellurium.” 2011. Doctoral Dissertation, University of Manchester. Accessed June 19, 2019. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:123912.

MLA Handbook (7^th Edition):

Khan, Rana. “Structural studies of Halogen, Interhalogen and Pseudohalogen Compounds of Phosphorus, Selenium and Tellurium.” 2011. Web. 19 Jun 2019.

Vancouver:

Khan R. Structural studies of Halogen, Interhalogen and Pseudohalogen Compounds of Phosphorus, Selenium and Tellurium. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2019 Jun 19]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:123912.

Council of Science Editors:

Khan R. Structural studies of Halogen, Interhalogen and Pseudohalogen Compounds of Phosphorus, Selenium and Tellurium. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:123912

Oregon State University

7. McCoy, Kim Edward Monroe. Selenomethionine and methionine in in vitro rabbit reticulocyte hemoglobin synthesis and in Escherichia coli tRNA aminoacylation.

Degree: PhD, Biochemistry and Biophysics, 1970, Oregon State University

URL: http://hdl.handle.net/1957/45708

► Selenomethionine and methionine have been postulated to be similarly involved in protein synthesis. This thesis has evaluated this hypothesis from a molecular and genetic approach.… (more)

▼ Selenomethionine and methionine have been postulated to be similarly involved in protein synthesis. This thesis has evaluated this hypothesis from a molecular and genetic approach. Selenomethionine and methionine were incorporated into rabbit reticulocyte hemoglobin at the same rates and in equal quantities. Each methionine demonstrated competitive inhibition for its analog incorporation into the globin. There were no significant differences in a or (3 chains for the methionine or selenomethionine rates of incorporation. Ion-exchange peptide analysis from a tryptic hydrolysate from this globin showed that selenomethionine and methionine were probably incorporated into the same peptides. However the peptides containing selenomethionine were somewhat displaced from the peptides containing methionine. When methyl labeled methionine and selenium labeled selenomethionine were incorporated into the globin, both their activities could be reduced 56-76% with dialysis against sodium sulfite. It was concluded that this sulfitolysis procedure was removing activity from the methionine and selenomethionine residues in the globin. There was no difference in selenomethionine or methionine aminoacylation of tRNA using materials from normal or selenium adapted Escherichia coli B. Both methionine and selenomethionine were rapidly bound in this system. Assay by plating on membrane filters demonstrated a higher binding of selenomethionine than methionine. However, assays by reverse phase chromatography showed that methionine and selenomethionine were bound in equal amounts and to the same two tRNA species. The two methionines were competitive inhibitors of each other for the aminoacylation of tRNA. Aminoacyl synthetase and tRNA were then prepared free of ribonuclease. Both selenomethionine and methionine had about the same optimum aminoacylation conditions: enzyme and tRNA concentration, ATP/Mg ratios, and pH range. Both aminoacylations were completely dependent upon added ATP. Sodium ion inhibited both aminoacylations, but could be overcome by potassium ion. Selenomethionine was aminoacylated faster and in preference to methionine, but showed no saturation of tRNA when selenomethionine concentration was increased. Aminoacylated selenomethionine- and methionine-tRNA could be deaminoacylated at pH 8.8, and then reaminoacylated to the same degree. Reverse phase column chromatography indicated that from this ribonuclease free material, there was only one methionine accepting tRNA species, which was identical in position and stoichiometry to the selenomethionine accepting tRNA species. Advisors/Committee Members: Weswig, Paul H. (advisor).

Subjects/Keywords: Selenium

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APA (6^th Edition):

McCoy, K. E. M. (1970). Selenomethionine and methionine in in vitro rabbit reticulocyte hemoglobin synthesis and in Escherichia coli tRNA aminoacylation. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45708

Chicago Manual of Style (16^th Edition):

McCoy, Kim Edward Monroe. “Selenomethionine and methionine in in vitro rabbit reticulocyte hemoglobin synthesis and in Escherichia coli tRNA aminoacylation.” 1970. Doctoral Dissertation, Oregon State University. Accessed June 19, 2019. http://hdl.handle.net/1957/45708.

MLA Handbook (7^th Edition):

McCoy, Kim Edward Monroe. “Selenomethionine and methionine in in vitro rabbit reticulocyte hemoglobin synthesis and in Escherichia coli tRNA aminoacylation.” 1970. Web. 19 Jun 2019.

Vancouver:

McCoy KEM. Selenomethionine and methionine in in vitro rabbit reticulocyte hemoglobin synthesis and in Escherichia coli tRNA aminoacylation. [Internet] [Doctoral dissertation]. Oregon State University; 1970. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1957/45708.

Council of Science Editors:

McCoy KEM. Selenomethionine and methionine in in vitro rabbit reticulocyte hemoglobin synthesis and in Escherichia coli tRNA aminoacylation. [Doctoral Dissertation]. Oregon State University; 1970. Available from: http://hdl.handle.net/1957/45708

Michigan State University

8. Daudi, Anwar Rahman, 1940-. Mechanical strength and fracture studies of partially crystallized selenium.

Degree: PhD, Department of Metallurgy, Mechanics, and Materials Science, 1974, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:24935

Subjects/Keywords: Selenium

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APA (6^th Edition):

Daudi, Anwar Rahman, 1. (1974). Mechanical strength and fracture studies of partially crystallized selenium. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:24935

Chicago Manual of Style (16^th Edition):

Daudi, Anwar Rahman, 1940-. “Mechanical strength and fracture studies of partially crystallized selenium.” 1974. Doctoral Dissertation, Michigan State University. Accessed June 19, 2019. http://etd.lib.msu.edu/islandora/object/etd:24935.

MLA Handbook (7^th Edition):

Daudi, Anwar Rahman, 1940-. “Mechanical strength and fracture studies of partially crystallized selenium.” 1974. Web. 19 Jun 2019.

Vancouver:

Daudi, Anwar Rahman 1. Mechanical strength and fracture studies of partially crystallized selenium. [Internet] [Doctoral dissertation]. Michigan State University; 1974. [cited 2019 Jun 19]. Available from: http://etd.lib.msu.edu/islandora/object/etd:24935.

Council of Science Editors:

Daudi, Anwar Rahman 1. Mechanical strength and fracture studies of partially crystallized selenium. [Doctoral Dissertation]. Michigan State University; 1974. Available from: http://etd.lib.msu.edu/islandora/object/etd:24935

University of Waikato

9. Lobb, Richard. Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation .

Degree: 2011, University of Waikato

URL: http://hdl.handle.net/10289/5709

► Selenium (Se) is an essential trace mineral required in maintaining health in humans. Recent research has demonstrated that Se shows promise as an agent that… (more)

▼ Selenium (Se) is an essential trace mineral required in maintaining health in humans. Recent research has demonstrated that Se shows promise as an agent that can reduce the harmful side-effects of chemotherapy (CT) and radiotherapy (RT), while not compromising the effectiveness of treatment. Clinical evaluations using varying doses of Se have demonstrated a significant reduction in toxicity of CT and RT. Se supplementation appears to mediate its biological effects through four main mechanisms: Se treatment promotes the death of malignant cells, but not normal cells, through the differential effects on the endoplasmic reticulum stress response; it inhibits hypoxia-induced angiogenesis which is required by tumours for their blood supply; it enhances DNA repair in normal but not malignant cells; and it reverses cellular resistance to some cytotoxic drugs. The objectives of this thesis were to evaluate the biological characteristics of the differential impact of a Se compound, methylseleninic acid (MSA), on malignant and non-malignant human cells and how that modulates the effects of cisplatin chemotherapy and/or radiation. In parallel with this, similar evaluations were undertaken in patients receiving a Se compound or placebo in conjunction with cisplatin and radiation for head and neck squamous cell carcinoma (HNSCC). MSA induced differential effects in peripheral blood mononuclear cells (PBMC) obtained from healthy individuals compared to the monocytic leukaemia THP-1 cell-line. While MSA did not change PBMC viability, it reduced that of THP-1 cells in a concentration-dependent manner. Furthermore, MSA treatment enhanced the cytotoxicity of CT and RT toward THP-1 cells without compromising the survival of PBMC. This increased sensitivity in THP-1 cells is likely to be related to significantly reduced levels of intracellular glutathione (GSH) in response to MSA. In contrast, GSH levels in PBMC rose substantially in response to MSA. Assessment of ER stress response proteins revealed that pro-survival proteins (GRP78, phospho-eIF2α, and spliced XBP-1) were upregulated in PBMC in response to MSA treatment. The malignant THP-1 cells had high levels of pro-survival proteins at baseline, which increased to a variable degree, especially caspase-8, in response to MSA. Putative pharmacodynamic markers of biological activity of Se were evaluated in plasma samples and PBMC from HNSCC patients in a randomised, placebo-controlled, double-blind phase II trial. Patients were treated with a 7-week radical course of concurrent cisplatin and RT (CRT) and were randomised to receive either selenomethionine (SLM) or matching placebo for 11 weeks, starting a week prior to CRT treatment. Because the trial is not yet complete, treatment allocation remains blinded and thus the pharmacodynamic results according to treatment with SLM or placebo cannot be made at the time of writing this thesis. However, markers of angiogenesis and the selenoprotein glutathione peroxidise 3 were measured and shown to significantly change during the course of… Advisors/Committee Members: Cursons, Raymond T (advisor).

Subjects/Keywords: selenium cancer

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APA (6^th Edition):

Lobb, R. (2011). Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation . (Masters Thesis). University of Waikato. Retrieved from http://hdl.handle.net/10289/5709

Chicago Manual of Style (16^th Edition):

Lobb, Richard. “Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation .” 2011. Masters Thesis, University of Waikato. Accessed June 19, 2019. http://hdl.handle.net/10289/5709.

MLA Handbook (7^th Edition):

Lobb, Richard. “Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation .” 2011. Web. 19 Jun 2019.

Vancouver:

Lobb R. Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation . [Internet] [Masters thesis]. University of Waikato; 2011. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10289/5709.

Council of Science Editors:

Lobb R. Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation . [Masters Thesis]. University of Waikato; 2011. Available from: http://hdl.handle.net/10289/5709

University of British Columbia

10. Schneider, Harvey Roy. The decay scheme of Se⁷⁵ .

Degree: 1957, University of British Columbia

URL: http://hdl.handle.net/2429/40460

► Excited levels of As⁷⁵ were investigated by studying the decay of Se⁷⁵. Scintillation detection techniques were employed to measure, the relative gamma ray intensities, gamma-gamma… (more)

Subjects/Keywords: Selenium

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APA (6^th Edition):

Schneider, H. R. (1957). The decay scheme of Se⁷⁵ . (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/40460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schneider, Harvey Roy. “The decay scheme of Se⁷⁵ .” 1957. Thesis, University of British Columbia. Accessed June 19, 2019. http://hdl.handle.net/2429/40460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schneider, Harvey Roy. “The decay scheme of Se⁷⁵ .” 1957. Web. 19 Jun 2019.

Vancouver:

Schneider HR. The decay scheme of Se⁷⁵ . [Internet] [Thesis]. University of British Columbia; 1957. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2429/40460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schneider HR. The decay scheme of Se⁷⁵ . [Thesis]. University of British Columbia; 1957. Available from: http://hdl.handle.net/2429/40460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

11. Derrick, Jack Bryan Devereux. Studies in selenium toxicology with particular reference to chemotherapeutic means of treatment .

Degree: 1949, University of British Columbia

URL: http://hdl.handle.net/2429/41265

► 1. The experimental evidence of the present work in selenium toxicology is such as to cast grave doubts on the authenticity of some aspects of… (more)

▼ 1. The experimental evidence of the present work in selenium toxicology is such as to cast grave doubts on the authenticity of some aspects of the work of previous investigators in this field. The response of the laboratory animals, subjected to the various procedures practised by these investigators in attempts to produce a condition of chronic selenium poisoning, suggests that these animals are, in addition to being the victims of selenium poisoning, the victims of inanition and/or dehydration. 2. The presence of up to 15 p.p.m. sodium selenite (6.9 p.p.m. Se) in the drinking water is tolerated without any drastic reduction in food and water intake by laboratory rats, provided that this concentration is reached gradually. At this level of selenium intake the animals will remain for at least 25 weeks in good condition and will exhibit growth only slightly less rapid than that of control animals. Any attempts to raise the selenium content above this level results In a compensatory lowering of the water intake and a resultant reduction in food intake of the animals. 3. The results obtained in the attempts to induce chronic selenium poisoning by dietary methods were such as to cause these methods to be abandoned due to their unsuitability for the present project. A method involving the subcutaneous injection of sub-lethal doses of sodium selenite incorporated into an absorption delaying vehicle was evolved and, after testing, was deemed suitable for the purpose of inducing a sub-acute condition of selenium toxicity to be used as a means of assessing the value of chemotherapy. 4. Experimental data on the urinary excretion levels of selenium was made available by the development of a new colorimetric procedure for the quantitative determination of selenium in biological samples. The data obtained by this method revealed that the maximum quantity of selenium excreted in the urine of rats over a period as long as ten days after injection was about one third of the quantity originally injected. No particular advantage in the use of the absorption delaying vehicle was discernable by this method but since, under the limitations imposed by the quantities of urine available, the delay in hours would be undetectable the vehicle was retained in the experiments assessing the value of BAL (2, 3-dithiopropanol) as a chemotherapeutic agent. 5. The use of BAL as a chemotherapeutic agent for combatting selenium toxicity has a deleterious effect on the intoxicated animals. The subcutaneous injection of quantities of BAL in peanut oil at levels considered well within the limits of safety resulted in an intensification of the distress of selenium injected rats. Deaths were more frequent than in the case of non BAL-treated animals. The animals which survived the effects of both poison and treatment showed a slightly higher and a more prolonged excretion of selenium in the urine. 6. Suggestions have been made for improved means of therapy for acute and sub-acute selenium poisoning involving the use of a less toxic dithiol…

Subjects/Keywords: Selenium

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APA (6^th Edition):

Derrick, J. B. D. (1949). Studies in selenium toxicology with particular reference to chemotherapeutic means of treatment . (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/41265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Derrick, Jack Bryan Devereux. “Studies in selenium toxicology with particular reference to chemotherapeutic means of treatment .” 1949. Thesis, University of British Columbia. Accessed June 19, 2019. http://hdl.handle.net/2429/41265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Derrick, Jack Bryan Devereux. “Studies in selenium toxicology with particular reference to chemotherapeutic means of treatment .” 1949. Web. 19 Jun 2019.

Vancouver:

Derrick JBD. Studies in selenium toxicology with particular reference to chemotherapeutic means of treatment . [Internet] [Thesis]. University of British Columbia; 1949. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2429/41265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Derrick JBD. Studies in selenium toxicology with particular reference to chemotherapeutic means of treatment . [Thesis]. University of British Columbia; 1949. Available from: http://hdl.handle.net/2429/41265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

12. Wilson, William W. Vibrational spectroscopic studies of some simple and mixed selenium (iv) oxy-halides and pseudohalides.

Degree: 1972, University of British Columbia

URL: http://hdl.handle.net/2429/33169

► The infrared and polarized Raman spectra of SeOBr₂ as a solid, melt, and in solution have been obtained. The frequencies that were found are consistent… (more)

Subjects/Keywords: Selenium

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APA (6^th Edition):

Wilson, W. W. (1972). Vibrational spectroscopic studies of some simple and mixed selenium (iv) oxy-halides and pseudohalides. (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/33169

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wilson, William W. “Vibrational spectroscopic studies of some simple and mixed selenium (iv) oxy-halides and pseudohalides. ” 1972. Thesis, University of British Columbia. Accessed June 19, 2019. http://hdl.handle.net/2429/33169.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wilson, William W. “Vibrational spectroscopic studies of some simple and mixed selenium (iv) oxy-halides and pseudohalides. ” 1972. Web. 19 Jun 2019.

Vancouver:

Wilson WW. Vibrational spectroscopic studies of some simple and mixed selenium (iv) oxy-halides and pseudohalides. [Internet] [Thesis]. University of British Columbia; 1972. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2429/33169.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wilson WW. Vibrational spectroscopic studies of some simple and mixed selenium (iv) oxy-halides and pseudohalides. [Thesis]. University of British Columbia; 1972. Available from: http://hdl.handle.net/2429/33169

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

13. George, Simon. A study of the spark spectra of selenium .

Degree: 1962, University of British Columbia

URL: http://hdl.handle.net/2429/38935

► The spark spectra of selenium have been photographed from the infra-red to the vacuum ultra-violet on a variety of spectrographs including a two meter vacuum… (more)

Subjects/Keywords: Selenium

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APA (6^th Edition):

George, S. (1962). A study of the spark spectra of selenium . (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/38935

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

George, Simon. “A study of the spark spectra of selenium .” 1962. Thesis, University of British Columbia. Accessed June 19, 2019. http://hdl.handle.net/2429/38935.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

George, Simon. “A study of the spark spectra of selenium .” 1962. Web. 19 Jun 2019.

Vancouver:

George S. A study of the spark spectra of selenium . [Internet] [Thesis]. University of British Columbia; 1962. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2429/38935.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

George S. A study of the spark spectra of selenium . [Thesis]. University of British Columbia; 1962. Available from: http://hdl.handle.net/2429/38935

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

14. Xiao, Wenda. Dendrimer Functionalized Graphene Oxide for Selenium Removal.

Degree: MS, Department of Chemical and Materials Engineering, 2015, University of Alberta

URL: https://era.library.ualberta.ca/files/n296x173x

► Selenium is an essential trace element nutrient for human life, but it can be extremely toxic if taken excess. Various adsorbents have been applied for… (more)

Subjects/Keywords: graphene oxide; selenium

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APA (6^th Edition):

Xiao, W. (2015). Dendrimer Functionalized Graphene Oxide for Selenium Removal. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/n296x173x

Chicago Manual of Style (16^th Edition):

Xiao, Wenda. “Dendrimer Functionalized Graphene Oxide for Selenium Removal.” 2015. Masters Thesis, University of Alberta. Accessed June 19, 2019. https://era.library.ualberta.ca/files/n296x173x.

MLA Handbook (7^th Edition):

Xiao, Wenda. “Dendrimer Functionalized Graphene Oxide for Selenium Removal.” 2015. Web. 19 Jun 2019.

Vancouver:

Xiao W. Dendrimer Functionalized Graphene Oxide for Selenium Removal. [Internet] [Masters thesis]. University of Alberta; 2015. [cited 2019 Jun 19]. Available from: https://era.library.ualberta.ca/files/n296x173x.

Council of Science Editors:

Xiao W. Dendrimer Functionalized Graphene Oxide for Selenium Removal. [Masters Thesis]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/n296x173x

University of Alberta

15. Fernandopulle, Shimal Chamikara. Selenium-stabilized carbanions and synthetic studies on the marinopyrroles.

Degree: PhD, Department of Chemistry, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/dj52w5900

► The first chapter of this thesis describes the development of a general route for the generation of selenium stabilized carbanions via a method that bypasses… (more)

▼ The first chapter of this thesis describes the development of a general route for the generation of selenium stabilized carbanions via a method that bypasses acid catalyzed formation of selenoacetals. Aldehydes are first converted into α-hydroxystannanes by nucleophilic addition of Bu3SnLi. The resulting hydroxyl is then converted to the corresponding phenyl selenide by treatment with PhSeCN and Bu3P to give the α-(phenylseleno)stannane. Upon treatment with BuLi, the α-(phenylseleno)stannane undergoes preferential Sn/Li exchange to give a selenium stabilized carbanion. This carbanion is condensed with an aldehyde to give a β-hydroxy selenide, which can be converted into an allylic alcohol upon oxidation and selenoxide fragmentation. The formation of α-(phenylseleno)stannanes has been applied to aldehydes containing straight and branched alkyl chains, aromatic substituents, and acid sensitive functional groups. The selenium stabilized carbanions have been condensed with aldehydes containing straight and branched alkyl chains, aromatic substituents, and α,β-unsaturation. The second chapter describes synthetic studies towards two marine natural products, marinopyrrole A and B. The synthesis began with the preparation of the unprecedented N,C2 linked bispyrrole core through a Paal-Knorr condensation onto the amino group of ethyl 3-aminopyrrole-2-carboxylate. Preparation of the densely halogenated core of the marinopyrroles through selective chlorination of the bispyrrole seems to be impossible and was not pursued. Due to unexpected alterations to the electronic structure of the pyrrole ring in the presence of electron withdrawing substituents, preparation of a fully functionalized top ring was unsuccessful. Blocking the 3' position of the bispyrrole with a removable blocking group was also unsuccessful by an ortho metallation approach. Preparation of the halogenated bispyrrole starting with the fully functionalized bottom pyrrole seems promising after a model intramolecular conjugate displacement reaction had shown that it is possible to mount the precursor to the top pyrrole on top of the bottom pyrrole. Work is in progress to prepare the mountable precursor to the top ring.

Subjects/Keywords: selenium; carbanions; marinopyrrole

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APA (6^th Edition):

Fernandopulle, S. C. (2012). Selenium-stabilized carbanions and synthetic studies on the marinopyrroles. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/dj52w5900

Chicago Manual of Style (16^th Edition):

Fernandopulle, Shimal Chamikara. “Selenium-stabilized carbanions and synthetic studies on the marinopyrroles.” 2012. Doctoral Dissertation, University of Alberta. Accessed June 19, 2019. https://era.library.ualberta.ca/files/dj52w5900.

MLA Handbook (7^th Edition):

Fernandopulle, Shimal Chamikara. “Selenium-stabilized carbanions and synthetic studies on the marinopyrroles.” 2012. Web. 19 Jun 2019.

Vancouver:

Fernandopulle SC. Selenium-stabilized carbanions and synthetic studies on the marinopyrroles. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2019 Jun 19]. Available from: https://era.library.ualberta.ca/files/dj52w5900.

Council of Science Editors:

Fernandopulle SC. Selenium-stabilized carbanions and synthetic studies on the marinopyrroles. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/dj52w5900

University of Kashmir

16. Shah, Mohammad Amin. Studies on Metal complexes with Sulphur and Selenium Ligands;.

Degree: 2014, University of Kashmir

URL: http://shodhganga.inflibnet.ac.in/handle/10603/23988

►

The work presented in this thesis deals with the review of literature and incorporates the studies of Hg II TLA and Hg II MPA systems… (more)

Subjects/Keywords: Sulphur-Selenium Ligands

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APA (6^th Edition):

Shah, M. A. (2014). Studies on Metal complexes with Sulphur and Selenium Ligands;. (Thesis). University of Kashmir. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/23988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shah, Mohammad Amin. “Studies on Metal complexes with Sulphur and Selenium Ligands;.” 2014. Thesis, University of Kashmir. Accessed June 19, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/23988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shah, Mohammad Amin. “Studies on Metal complexes with Sulphur and Selenium Ligands;.” 2014. Web. 19 Jun 2019.

Vancouver:

Shah MA. Studies on Metal complexes with Sulphur and Selenium Ligands;. [Internet] [Thesis]. University of Kashmir; 2014. [cited 2019 Jun 19]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/23988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shah MA. Studies on Metal complexes with Sulphur and Selenium Ligands;. [Thesis]. University of Kashmir; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/23988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

17. Aborode, Fatai Adigun. Selenium and arsenic speciation in plants.

Degree: PhD, 2013, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201647 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577621

► Selenium and arsenic are important metalloids in the food chain from nutritional and toxicological point of view. These two metalloids are potentially enriched through geogenic… (more)

▼ Selenium and arsenic are important metalloids in the food chain from nutritional and toxicological point of view. These two metalloids are potentially enriched through geogenic processes and anthropogenic activities and they could sometimes co-exist in nature and become available to plants thereby entering the food chain. While selenium is known as an essential element to humans, it could also be toxic. Arsenic on the other hand is a potentially toxic element posing serious health risks to livestock and humans. They have been found to neutralise each other’s effects in animals but their interactions in plants are not well understood. Speciation analysis, which is a set of activities leading to identification and quantification of different forms or species of elements present in an entity, is required for a holistic understanding of the mechanisms and interactions involved in the plants’ metabolism of contaminants and essential elements. Many techniques are currently being used for speciation of selenium and arsenic in plants and they sometimes give contradictory outcomes. The hyphenation of HPLC with MS and synchrotron techniques are the two most commonly used state of the art techniques for speciation of these metalloids. This research therefore sought to access, explore and/ or develop analytical methods appropriate for the speciation of selenium and arsenic in plants. Many selenium and arsenic species have been identified and reported in the literature using well established procedures. The presence of elemental selenium in plants has also been widely reported in plants but to our knowledge this presence has never been experimentally proven and fully quantified. Because this species is non toxic, its proven occurrence in plants will represent a potential detoxification mechanism. Therefore in this study, a method was specifically developed for identification and quantification of elemental selenium. In order to investigate the occurrence of elemental selenium in plants, the newly developed method was applied using Thunbergia alata as a model plant. Arsenic is known to activate the synthesis of PC using glutathione and the complexation of the activating arsenic ions with the synthesised PCs is a well established detoxification mechanism for arsenic. However, very little is known about the role of glutathione and PCs in selenium detoxification. In order to be able to gain better insight into the interaction between selenium and arsenic in plants, the role of glutathione and PCs in selenium metabolism was investigated using Arabidopsis thaliana as a model plant. Sensitivity tests and speciation analysis were carried out on Arabidopsis thaliana WT and the mutants’ one of which is deficient in GSH synthesis and the other deficient in PC synthesis using selenite and arsenate as toxicants. The study revealed that selenium induces the synthesis of glutathione but rather use it as reductant and precursor for transformation and incorporation into peptides and neither GSH nor PCs play any role in selenium detoxification. It…

Subjects/Keywords: 540; Selenium; Arsenic

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APA (6^th Edition):

Aborode, F. A. (2013). Selenium and arsenic speciation in plants. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201647 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577621

Chicago Manual of Style (16^th Edition):

Aborode, Fatai Adigun. “Selenium and arsenic speciation in plants.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed June 19, 2019. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201647 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577621.

MLA Handbook (7^th Edition):

Aborode, Fatai Adigun. “Selenium and arsenic speciation in plants.” 2013. Web. 19 Jun 2019.

Vancouver:

Aborode FA. Selenium and arsenic speciation in plants. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2019 Jun 19]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201647 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577621.

Council of Science Editors:

Aborode FA. Selenium and arsenic speciation in plants. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201647 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577621

University of Hawaii – Manoa

18. Raman, Arjun Venkat. Utilization of selenium in the mouse brain : implications for neurological disease.

Degree: 2016, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/101018

►

Ph.D. University of Hawaii at Manoa 2012.

Selenium is a chemical element that is an essential micronutrient associated with various aspects of human health. The… (more)

▼

Ph.D. University of Hawaii at Manoa 2012.

Selenium is a chemical element that is an essential micronutrient associated with various aspects of human health. The biochemical activity of selenium is mediated by proteins, which incorporate it into the amino acid selenocysteine (Sec). There are 25 genes in humans encoding Sec-containing selenoproteins. The functionally characterized selenoproteins are oxidoreductase enzymes involved in cellular oxidation-reduction reactions. Most selenoproteins are expressed in the mammalian brain, and dietary selenium deficiency causes preferential retention in brain relative to other body organs. Further, dietary selenium deficiency and specific selenoproteins are associated with various brain diseases. Mouse models have been extensively used to study the function and handling of selenium in mammals. Genetic deletion of a Sec-rich protein in mice causes brain selenium deficiency, neurodegeneration and neurological impairment, and disruption of a phospholipid hydroperoxidase selenoenzyme causes rapid neurodegeneration. Therefore, selenoprotein expression and function promotes a healthy nervous system. However, selenium metabolism and the function of several selenoproteins in brain are not clearly defined. The overall purpose of this work is to clarify the function and utilization of selenium in the mammalian brain, to reveal implications for developmental and neurological diseases. The goal of these studies is to investigate changes in brain function and selenoprotein expression under conditions of altered selenium metabolism in mice. The research presented in this dissertation covers three major topics that are separated into chapters. To investigate selenium distribution in the brain, the neurological consequences of disrupting selenium transport and recycling in mice are assessed and compared. Disruption of selenium transport caused more profound neurological consequences than disruption of selenium recycling. To investigate potential functions of selenium in the nervous system, select selenoproteins were examined for cellular and subcellular expression in cells and brain tissue from transgenic and control mice. Select selenoproteins and synthesis factors were observed at synapses, suggesting localized expression and physiological relevance. To investigate a potential interaction between selenium and methamphetamine, expression profiling of selenoproteins in mouse brain after exposure to methamphetamine is described. Selenoprotein synthesis was adversely affected by methamphetamine administration in mice. These results confirm the importance of selenium in the mammalian brain.

Subjects/Keywords: selenium; mouse; brain

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APA (6^th Edition):

Raman, A. V. (2016). Utilization of selenium in the mouse brain : implications for neurological disease. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Raman, Arjun Venkat. “Utilization of selenium in the mouse brain : implications for neurological disease.” 2016. Thesis, University of Hawaii – Manoa. Accessed June 19, 2019. http://hdl.handle.net/10125/101018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Raman, Arjun Venkat. “Utilization of selenium in the mouse brain : implications for neurological disease.” 2016. Web. 19 Jun 2019.

Vancouver:

Raman AV. Utilization of selenium in the mouse brain : implications for neurological disease. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10125/101018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Raman AV. Utilization of selenium in the mouse brain : implications for neurological disease. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

19. Khan, Rana. Structural studies of halogen, interhalogen and pseudohalogen compounds of phosphorus, selenium and tellurium.

Degree: PhD, 2011, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/structural-studies-of-halogen-interhalogen-and-pseudohalogen-compounds-of-phosphorus-selenium-and-tellurium(b1ba6ec9-198c-4de5-be73-f136a4db3ee0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539995

► A series of compounds with the general formula R3PX2 and R3PX4 (where R = o-tolyl, m-tolyl, p-tolyl, o-anisyl, m-anisyl, p-anisyl, o-thioanisyl, p-thioanisyl, p-fluorophenyl, p-chlorophenyl, mesityl… (more)

Subjects/Keywords: 546.3; Selenium; Phosphorus

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APA (6^th Edition):

Khan, R. (2011). Structural studies of halogen, interhalogen and pseudohalogen compounds of phosphorus, selenium and tellurium. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/structural-studies-of-halogen-interhalogen-and-pseudohalogen-compounds-of-phosphorus-selenium-and-tellurium(b1ba6ec9-198c-4de5-be73-f136a4db3ee0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539995

Chicago Manual of Style (16^th Edition):

Khan, Rana. “Structural studies of halogen, interhalogen and pseudohalogen compounds of phosphorus, selenium and tellurium.” 2011. Doctoral Dissertation, University of Manchester. Accessed June 19, 2019. https://www.research.manchester.ac.uk/portal/en/theses/structural-studies-of-halogen-interhalogen-and-pseudohalogen-compounds-of-phosphorus-selenium-and-tellurium(b1ba6ec9-198c-4de5-be73-f136a4db3ee0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539995.

MLA Handbook (7^th Edition):

Khan, Rana. “Structural studies of halogen, interhalogen and pseudohalogen compounds of phosphorus, selenium and tellurium.” 2011. Web. 19 Jun 2019.

Vancouver:

Khan R. Structural studies of halogen, interhalogen and pseudohalogen compounds of phosphorus, selenium and tellurium. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2019 Jun 19]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/structural-studies-of-halogen-interhalogen-and-pseudohalogen-compounds-of-phosphorus-selenium-and-tellurium(b1ba6ec9-198c-4de5-be73-f136a4db3ee0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539995.

Council of Science Editors:

Khan R. Structural studies of halogen, interhalogen and pseudohalogen compounds of phosphorus, selenium and tellurium. [Doctoral Dissertation]. University of Manchester; 2011. Available from: https://www.research.manchester.ac.uk/portal/en/theses/structural-studies-of-halogen-interhalogen-and-pseudohalogen-compounds-of-phosphorus-selenium-and-tellurium(b1ba6ec9-198c-4de5-be73-f136a4db3ee0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539995

University of Saskatchewan

20. Pettem, Connor Maurice 1991-. Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes.

Degree: 2018, University of Saskatchewan

URL: http://hdl.handle.net/10388/8475

► Selenium (Se) is an essential micronutrient involved in important metabolic functions for all vertebrate species. As Se is reported to have a narrow margin between… (more)

▼ Selenium (Se) is an essential micronutrient involved in important metabolic functions for all vertebrate species. As Se is reported to have a narrow margin between essentiality and toxicity, there is growing concern surrounding the adverse effects of elevated Se exposure caused by anthropogenic activities. Recent studies have reported that elevated dietary exposure of fish to selenomethionine (Se-Met) can alter aerobic metabolic capacity, energetics and swimming performance. My thesis aimed to further investigate mechanisms of sublethal Se-Met toxicity, particularly potential underlying cardiovascular implications of chronic exposure to environmentally relevant concentrations of dietary Se-Met in adult zebrafish (Danio rerio) and juvenile (yearling) rainbow trout (Oncorhynchus mykiss). In my first experiment, adult zebrafish were fed either control food (1.1 μg Se/g dry mass [d.m.]) or Se-Met spiked food (10.3 or 28.8 μg Se/g d.m.) for 90 d at 5% body weight per day. In the second experiment, juvenile rainbow trout were fed either control food (1.3 μg Se/g d.m.) or Se-Met spiked food (6.4, 15.8 or 47.8 μg Se/g d.m.) for 60 d at 5% body weight per day. Following exposure, ultrahigh resolution B-mode and Doppler ultrasound was used to characterize cardiac function. Chronic dietary exposure to elevated Se-Met had opposing results in zebrafish when compared to the rainbow trout. Zebrafish exposed to the highest dietary concentrations of Se-Met (28.8 μg Se/g d.m.) had significantly reduced ventricular contractile rate, stroke volume, and cardiac output, while Se-Met exposed rainbow trout had significantly greater stroke volume, ejection fraction, and cardiac output. Following ultasonography, energy stores were measured via whole body (zebrafish) and liver, heart and muscle (rainbow trout) glycogen and triglyceride concentrations. Zebrafish in the highest exposure group were observed to have greater whole body glycogen concentrations when compared to the control group, while rainbow trout exposed to Se-Met concentrations greater than 15.8 μg Se/g showed significant increases in both glycogen and triglycerides in liver relative to the control group. In addition, rainbow trout in the highest exposure group had significantly reduced capability of managing blood glucose levels as was evident after 48hrs in a glucose tolerance test. Exposure to Se-Met significantly decreased mRNA expression of a key cardiac remodelling enzyme, matrix metalloproteinase 2 (MMP2), in adult zebrafish heart, however significantly increased it (MMP9) in rainbow trout heart. Selenomethionine significantly increased echodensity at the junction between atrium and ventricle in zebrafish, and these results combined with increased MMP2 expression are consistent with cardiac remodelling and fibrosis. However, rainbow trout did not show any fibrosis and also had a significant decrease in SERPINH mRNA abundance, a molecular chaperone essential for the post-translational folding of fibril-forming collagens. This, taken together with the increase in MMP9,… Advisors/Committee Members: Janz, David M, Weber, Lynn P, Janz, David M, Weber, Lynn P, Blakley, Barry, Krone, Patrick, Tierney, Keith.

Subjects/Keywords: cardiometabolic; toxicity; selenium

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APA (6^th Edition):

Pettem, C. M. 1. (2018). Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/8475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pettem, Connor Maurice 1991-. “Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes.” 2018. Thesis, University of Saskatchewan. Accessed June 19, 2019. http://hdl.handle.net/10388/8475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pettem, Connor Maurice 1991-. “Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes.” 2018. Web. 19 Jun 2019.

Vancouver:

Pettem CM1. Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes. [Internet] [Thesis]. University of Saskatchewan; 2018. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10388/8475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pettem CM1. Cardiovascular and metabolic effects of dietary selenomethionine exposure in fishes. [Thesis]. University of Saskatchewan; 2018. Available from: http://hdl.handle.net/10388/8475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Clemson University

21. Blaszkiewicz, Christina. BIOGEOCHEMICAL PROCESSES IN HYDROSOIL OF PILOT-SCALE CONSTRUCTED WETLAND TREATMENT SYSTEMS DESIGNED FOR TREATMENT OF SELENIUM.

Degree: MS, Hydrogeology, 2015, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/2212

► Two pilot-scale wetland treatment system cells (nutrient amended and unamended) were designed and constructed to reduce aqueous Se concentrations in simulated energy-derived water. Specific objectives… (more)

▼ Two pilot-scale wetland treatment system cells (nutrient amended and unamended) were designed and constructed to reduce aqueous Se concentrations in simulated energy-derived water. Specific objectives of this study were: (i) measure and correlate hydrosoil conditions with Se concentrations vertically through the hydrosoil; (ii) investigate Se-accumulating biogeochemical processes (dissimilatory Se reduction and sorption) operating in the hydrosoil; and (iii) evaluate the effect of a nutrient amendment on hydrosoil conditions, Se accumulation, and Se-sequestering biogeochemical processes in the hydrosoil. Se accumulation (i.e. total Se concentration) and hydrosoil conditions were measured with depth in the hydrosoil. Se-sequestering biogeochemical processes were investigated by counting Se-reducing microbial colony forming units (CFUs) and identifying Se geochemical fractions at various depths in the hydrosoil. The detritus (0-21 cm in nutrient amended cell and 0-14 cm in unamended cell) contained greater Se concentrations (308-830 Âµg/g and 138-569 Âµg/g) and greater CFUs (2,700-22,000 CFUs/mL pore water and 9,300-15,000 CFUs/mL pore water) than the underlying sandy sediment. Correlation of organic matter content with Se concentration (r = 0.95; p<0.00001 in nutrient amended and r = 0.87; p<0.00002 in unamended) suggests organic matter influences Se-accumulating biogeochemical processes. In detritus, mean hydrosoil conditions (redox: -2 to -173 mV, pH: 6.20-6.46, and organic matter: 52-86%) were more favorable for sorption than for dissimilatory Se reduction; however, the majority of Se measured in the detritus was elemental (52.1%-58.0% in the nutrient amended cell and 21.1%-62.6% in the unamended cell) suggesting that dissimilatory Se reduction is the dominant biogeochemical process sequestering Se in the detritus. T-tests indicate significant difference in pH (t = 2.87, p = 0.0132) of the hydrosoil between the nutrient amended cell and unamended cell, but no significant differences (p<0.005) in redox potential, organic matter content, and Se concentration. Greater Se concentrations and percent of elemental Se in the nutrient amended cell than the unamended cell suggests that the nutrient amendment enhanced dissimilatory Se reduction and therefore Se accumulation in the hydrosoil. Advisors/Committee Members: Castle, James W, Rodgers, John H, Powell, Brian A.

Subjects/Keywords: Selenium; Wetlands; Geology

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APA (6^th Edition):

Blaszkiewicz, C. (2015). BIOGEOCHEMICAL PROCESSES IN HYDROSOIL OF PILOT-SCALE CONSTRUCTED WETLAND TREATMENT SYSTEMS DESIGNED FOR TREATMENT OF SELENIUM. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/2212

Chicago Manual of Style (16^th Edition):

Blaszkiewicz, Christina. “BIOGEOCHEMICAL PROCESSES IN HYDROSOIL OF PILOT-SCALE CONSTRUCTED WETLAND TREATMENT SYSTEMS DESIGNED FOR TREATMENT OF SELENIUM.” 2015. Masters Thesis, Clemson University. Accessed June 19, 2019. https://tigerprints.clemson.edu/all_theses/2212.

MLA Handbook (7^th Edition):

Blaszkiewicz, Christina. “BIOGEOCHEMICAL PROCESSES IN HYDROSOIL OF PILOT-SCALE CONSTRUCTED WETLAND TREATMENT SYSTEMS DESIGNED FOR TREATMENT OF SELENIUM.” 2015. Web. 19 Jun 2019.

Vancouver:

Blaszkiewicz C. BIOGEOCHEMICAL PROCESSES IN HYDROSOIL OF PILOT-SCALE CONSTRUCTED WETLAND TREATMENT SYSTEMS DESIGNED FOR TREATMENT OF SELENIUM. [Internet] [Masters thesis]. Clemson University; 2015. [cited 2019 Jun 19]. Available from: https://tigerprints.clemson.edu/all_theses/2212.

Council of Science Editors:

Blaszkiewicz C. BIOGEOCHEMICAL PROCESSES IN HYDROSOIL OF PILOT-SCALE CONSTRUCTED WETLAND TREATMENT SYSTEMS DESIGNED FOR TREATMENT OF SELENIUM. [Masters Thesis]. Clemson University; 2015. Available from: https://tigerprints.clemson.edu/all_theses/2212

22. Luhtasaari, Mikko. Käyttöliittymätestausautomaatio osana sovelluskehitysprosessia .

Degree: 2018, Theseus

URL: http://www.theseus.fi/handle/10024/149237

► Opinnäytetyön tilaaja oli Cybercom Finland Oy. Heidän HSY-mittaridata -projektissaan oli noussut esille tarve automatisoida järjestelmätestausta. Opinnäytetyön tavoitteena oli tutkia, miten käyttöliittymätestausautomaatiota voitaisiin hyödyntää sovelluskehitysprosessissa. Tarkoituksena… (more)

▼ Opinnäytetyön tilaaja oli Cybercom Finland Oy. Heidän HSY-mittaridata -projektissaan oli noussut esille tarve automatisoida järjestelmätestausta. Opinnäytetyön tavoitteena oli tutkia, miten käyttöliittymätestausautomaatiota voitaisiin hyödyntää sovelluskehitysprosessissa. Tarkoituksena oli rakentaa käyttöliittymätestausautomaatio HSY-mittaridata-projektille. Käyttöliittymätestausautomaatio voidaan luokitella kuuluvaksi järjestelmätestaukseen. Testaus olisi ollut hyvä ottaa osaksi prosessia jo varhaisemmassa vaiheessa projektia parhaiden tulosten saamiseksi. Selenium WebDriver osoittautui erinomaiseksi frameworkiksi laajemman käyttöliittymätestausautomaation rakentamisessa. Google Chrome -selain valittiin sopivimmaksi testiselaimeksi sen tarjoaman headless-tilan ja mobiiliemuloinnin vuoksi. CI-palvelimella on mahdollista suorittaa testejä ilman näytönohjainta. Raportointia ja seurantaa tulisi parantaa resurssien käyttämisen tehostamiseksi. Toisaalta frameworkin valinta tulisi suorittaa aina nykytila huomioiden frameworkien nopean kehityksen vuoksi. Erilaisten testi-frameworkien tarjoamiin ominaisuuksiin tulisi tutusta paremmin. Nykyaikaisten JS-frameworkien toimintaa tulisi selvittää enemmän, ja sen pohjalta laatia yleispätevämpiä ratkaisuja epävakauden korjaamiseksi.; The bachelor’s thesis was done for Cybercom Finland Oy. Their HSY-meter data project needed test automation to help with the software development process. The goal of this thesis was to research how to implement user interface test automation into a modern software development process. The purpose was to build user interface test automation for the meter data project. User interface is categorized as system testing. It should have been implemented earlier in the project for the best results. Selenium WebDriver turned out to be an excellent framework for building the user interface test automation. Google Chrome was chosen as the best browser for testing because it supports both mobile emulation and headless-mode. It is possible to run user interface tests on a CI-server without graphics card. Reporting and follow-up should be improved to allow for better planning and resource allocation. When choosing the framework for user interface testing, one should always do their own research. Frameworks evolve at such a rapid pace and sometimes it comes down to personal programming language preferences. Other test frameworks besides JUnit should be researched more. JavaScript based frontend frameworks require more research to enable more stable tests in the future.

Subjects/Keywords: selenium; jenkins; junit

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APA (6^th Edition):

Luhtasaari, M. (2018). Käyttöliittymätestausautomaatio osana sovelluskehitysprosessia . (Thesis). Theseus. Retrieved from http://www.theseus.fi/handle/10024/149237

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Luhtasaari, Mikko. “Käyttöliittymätestausautomaatio osana sovelluskehitysprosessia .” 2018. Thesis, Theseus. Accessed June 19, 2019. http://www.theseus.fi/handle/10024/149237.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Luhtasaari, Mikko. “Käyttöliittymätestausautomaatio osana sovelluskehitysprosessia .” 2018. Web. 19 Jun 2019.

Vancouver:

Luhtasaari M. Käyttöliittymätestausautomaatio osana sovelluskehitysprosessia . [Internet] [Thesis]. Theseus; 2018. [cited 2019 Jun 19]. Available from: http://www.theseus.fi/handle/10024/149237.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Luhtasaari M. Käyttöliittymätestausautomaatio osana sovelluskehitysprosessia . [Thesis]. Theseus; 2018. Available from: http://www.theseus.fi/handle/10024/149237

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Waikato

23. Mayall, Kirsty Rose. In vitro Effects of Selenium on DNA Damage in BRCA1 Cell Lines .

Degree: 2015, University of Waikato

URL: http://hdl.handle.net/10289/11481

► Cancer of the breast is the most common cancer affecting women, with a 1 in 9 lifetime risk of developing breast cancer. Carriers of mutations… (more)

▼ Cancer of the breast is the most common cancer affecting women, with a 1 in 9 lifetime risk of developing breast cancer. Carriers of mutations in the breast cancer susceptibility gene, BRCA1, present with an increased lifetime risk of 80-95% of developing breast cancer. BRCA1 is a tumour-suppressor gene that is involved in DNA repair of double-strand breaks and transcriptional regulation. Studies have shown that oral supplementation with Selenium (Se) could potentially be an effective preventive agent against BRCA1-mutation carriers. Se is an essential trace mineral that plays critical roles in maintaining health in humans. Se functions by protecting lipid membranes, proteins and DNA from free radical damage and is involved in redox regulation in the cell. These functions are mediated through specific Se-dependent proteins termed selenoproteins, in which Se is incorporated. Se supplementation may exert its benefits by enhancing the DNA damage repair response. The effects also appear to be dependent on selenoprotein genotypes and concentration of Se in the body/diet. It is possible that Se supplementation may be effective in reducing the risk of breast cancer in BRCA1 carriers, but the use of organic Se compounds is likely to be preferable, but the dose-response needs to be determined. The objectives of this research thesis are to evaluate the dose-response of sodium selenite and methylseleninic acid (MSA) in two BRCA1-mutated cancer cell lines in vitro. The MTT assay was used to monitor cell activity, along with the comet assay to evaluate the DNA damage level using a dose-response curve of the two Se compounds on control and bleomycin-induced DNA damaged cells. In addition, DNA from each cell line was sequenced to confirm the presence of the published BRCA1 mutation. The data presented within this thesis demonstrates that a commonly-used inorganic form of Se, sodium selenite, is more genotoxic than the organic Se compound, MSA, in malignant BRCA1-mutated cells. Sodium selenite also has more direct cytotoxicity in BRCA1-mutated cells than MSA, as demonstrated by the MTT assay. However the enhanced repair capacity from Se on DNA damage in cells demonstrated by others has not been reproduced. Preliminary data showed potential at much lower doses (2 μM) of Se. Interestingly, the volatile metabolites produced from MSA appear to reduce DNA damage, supportive of this hypothesis. In order to understand if the effects observed are linked specifically to the BRCA1 mutation or breast cancer in general, future research should include the investigation of the effects of Se on breast cancer using alternative breast cancer cell lines, as well as non-malignant cells. Advisors/Committee Members: Peters, Linda (advisor), Jameson, Michael (advisor).

Subjects/Keywords: Selenium; Breast cancer

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APA (6^th Edition):

Mayall, K. R. (2015). In vitro Effects of Selenium on DNA Damage in BRCA1 Cell Lines . (Masters Thesis). University of Waikato. Retrieved from http://hdl.handle.net/10289/11481

Chicago Manual of Style (16^th Edition):

Mayall, Kirsty Rose. “In vitro Effects of Selenium on DNA Damage in BRCA1 Cell Lines .” 2015. Masters Thesis, University of Waikato. Accessed June 19, 2019. http://hdl.handle.net/10289/11481.

MLA Handbook (7^th Edition):

Mayall, Kirsty Rose. “In vitro Effects of Selenium on DNA Damage in BRCA1 Cell Lines .” 2015. Web. 19 Jun 2019.

Vancouver:

Mayall KR. In vitro Effects of Selenium on DNA Damage in BRCA1 Cell Lines . [Internet] [Masters thesis]. University of Waikato; 2015. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10289/11481.

Council of Science Editors:

Mayall KR. In vitro Effects of Selenium on DNA Damage in BRCA1 Cell Lines . [Masters Thesis]. University of Waikato; 2015. Available from: http://hdl.handle.net/10289/11481

University of Saskatchewan

24. Markwart, Blue E 1990-. Selenium Bioconcentration in Freshwater Periphyton.

Degree: 2019, University of Saskatchewan

URL: http://hdl.handle.net/10388/12058

► Selenium is an essential micronutrient for most forms of life, but it can elicit developmental toxicity in aquatic and semi-aquatic vertebrates, such as fish and… (more)

▼ Selenium is an essential micronutrient for most forms of life, but it can elicit developmental toxicity in aquatic and semi-aquatic vertebrates, such as fish and waterfowl, through dietary exposure to excess organic Se compounds. When inorganic Se (as selenate or selenite) is introduced into an aquatic ecosystem as a contaminant, it is bioconcentrated by microorganisms and primary producers (algae, periphyton), biotransformed into organic Se compounds and passed on to higher trophic levels through the food chain. The enrichment of Se in algae is difficult to predict due to interspecific differences in Se bioconcentration, which have been demonstrated to vary by several orders of magnitude in planktonic algae. In addition, Se bioconcentration data are largely lacking for freshwater, periphytic species of algae, and for multi-species periphyton biofilms, adding to the challenge of modeling Se transfer in periphyton-based food webs. Therefore, this research project was designed to address specific knowledge gaps related to the enrichment of selenium in different periphyton communities, as defined by differences in photoautrophic assemblage composition. To satisfy this objective, laboratory-grown and naturally-grown periphyton biofilms were exposed to environmentally relevant concentrations of selenite [Se(IV)] or selenate [Se(VI)] (nominal concentrations of 5 and 25 μg Se L-1) under similar, controlled laboratory conditions. Laboratory-grown periphyton biofilm experiments assessed Se oxyanion bioconcentration in single-species, freshwater periphytic biofilms representative of three major algal phyla: Chlorophyta (Stichococcus bacillaris), Cyanophyta (Anabaena flos-aquae) and Bacillariophyta (Asterionella formosa). Results of these experiments revealed that there was different enrichment of selenate versus selenite for the three species of algae tested (e.g., selenite enrichment was significantly higher than selenate enrichment for A. formosa). There were also significant differences in Se enrichment when comparing similar treatments among the three species of algae tested (e.g., enrichment of selenate was 3.6-fold higher in S. bacillaris compared to A. flos-aquae for the 25 μg Se L-1 treatment). Nevertheless, interspecific Se enrichment did not vary by orders of magnitude for freshwater periphyton, but rather by less than one order of magnitude. Naturally-grown periphyton experiments assessed Se oxyanion accumulation in freshwater periphyton communities sampled from five different water bodies. Results revealed that unique periphyton assemblages were derived from the five different field sites, as confirmed by light microscopy and targeted DNA sequencing of the plastid 23S rRNA gene in algae. Selenium accumulation demonstrated a maximum of 23.6-fold difference for selenite enrichment and 2.1-fold difference for selenate enrichment across the periphyton/biofilm assemblages tested. The assemblage from one field site demonstrated both high accumulation of selenite and iron, and was subjected to additional experimentation… Advisors/Committee Members: Doig, Lorne E, Liber, Karsten, Janz, David, Hecker, Markus, Eickhoff, Curtis.

Subjects/Keywords: selenium; periphyton; bioconcentration

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APA (6^th Edition):

Markwart, B. E. 1. (2019). Selenium Bioconcentration in Freshwater Periphyton. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Markwart, Blue E 1990-. “Selenium Bioconcentration in Freshwater Periphyton.” 2019. Thesis, University of Saskatchewan. Accessed June 19, 2019. http://hdl.handle.net/10388/12058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Markwart, Blue E 1990-. “Selenium Bioconcentration in Freshwater Periphyton.” 2019. Web. 19 Jun 2019.

Vancouver:

Markwart BE1. Selenium Bioconcentration in Freshwater Periphyton. [Internet] [Thesis]. University of Saskatchewan; 2019. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10388/12058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Markwart BE1. Selenium Bioconcentration in Freshwater Periphyton. [Thesis]. University of Saskatchewan; 2019. Available from: http://hdl.handle.net/10388/12058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

25. Swinehart, Philip Ross. Minority carrier kinetics in defect trap distributions and semiconductors : application to trigonal selenium single crystals .

Degree: PhD, Graduate School, 1974, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486990432996924

Subjects/Keywords: Physics; Selenium

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APA (6^th Edition):

Swinehart, P. R. (1974). Minority carrier kinetics in defect trap distributions and semiconductors : application to trigonal selenium single crystals . (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486990432996924

Chicago Manual of Style (16^th Edition):

Swinehart, Philip Ross. “Minority carrier kinetics in defect trap distributions and semiconductors : application to trigonal selenium single crystals .” 1974. Doctoral Dissertation, The Ohio State University. Accessed June 19, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486990432996924.

MLA Handbook (7^th Edition):

Swinehart, Philip Ross. “Minority carrier kinetics in defect trap distributions and semiconductors : application to trigonal selenium single crystals .” 1974. Web. 19 Jun 2019.

Vancouver:

Swinehart PR. Minority carrier kinetics in defect trap distributions and semiconductors : application to trigonal selenium single crystals . [Internet] [Doctoral dissertation]. The Ohio State University; 1974. [cited 2019 Jun 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486990432996924.

Council of Science Editors:

Swinehart PR. Minority carrier kinetics in defect trap distributions and semiconductors : application to trigonal selenium single crystals . [Doctoral Dissertation]. The Ohio State University; 1974. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486990432996924

University of Zululand

26. Oluwafemi, Samuel Oluwatobi. A new approach to the synthesis of selenium based nanoparticles .

Degree: 2008, University of Zululand

URL: http://hdl.handle.net/10530/67

► We report the synthesis of high quality aqueous and organically soluble selenide nanoparticles by a novel greener, quick, facile, environmentally-benign and effective non-organometallic solution-based method.… (more)

▼ We report the synthesis of high quality aqueous and organically soluble selenide nanoparticles by a novel greener, quick, facile, environmentally-benign and effective non-organometallic solution-based method. Briefly, the method involves the reduction of selenium powder to produce selenide ions which act as the selenide source, followed by the addition of MCI2 (M = Cd or Zn) or Zn(CH3COO)2. The nanoparticles were passivated with organic surfactants such as hexadecylamine (HDA) and tri-octylphosphine oxide (TOPO), for their solubility and stability in organic solvents, while passivation with biomolecules such as L-cysteine ethyl ester hydrochloride, methionine, ascorbic acid, starch, polyvinyl alcohol (PVA) and poly (vinylpyrroiidone) (PVP), rendered them water-soluble and aJso acted as an agent of stabilisation and facilitate conjugation with biomolecules. CdSe/ZnSe nano-composite and core-shell nanoparticles were also synthesised, using this new synthetic approach. The high quality of the as-synthesised nanoparticles was confirmed using absorption and photoluminescence spectroscopy (PL), Fourier transform infrared spectroscopy (FT-ER), powder x-ray diffraction (XRD), transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), selected area dififractometry (SAD) and energy dispersive spectroscopy (EDS). All measurements were performed without any post-preparative size separation of the nanoparticles. The thesis is divided into six chapters. Chapter one deals with the introduction and comprehensive review on previous works done on the synthesis of nanoparticies, VIII highlighting their advantages and disadvantages. The aim and objective of the study is also stated in this chapter. In chapter two, the systematic study of the effects of the capping group, growth time, temperature, reduction time and monomer concentration on the size, optical properties and morphology of the as-synthesized TOPO and HDA-capped CdSe nanoparticles was investigated. All the as-synthesised particles are blue-shifted in relation to the bulk band-gap of CdSe. The absorption and emission maxima are shifted to higher band-gap (lower wavelengths) as the reduction time increases from 2 to 6 hrs, indicating a decrease in particle size for the HDA-capped CdSe. The particle size ranges between, 2.3-3.2 (5-30 mins) 2.4-3.0 nm (5 -30 mins) and 2.5- 2.7 nm (15-30 mins) for the reduction time of 2,4 and 6 hrs respectively. At higher temperature (200 °C), particles with different shapes, i.e dot, rod and multi armed rods are produced. The presence of the elongated particles was attributed to the phenomenon of oriented attachment (self-assembly), due to dipole-dipole interactions between the highly charged surfaces of II-VI semiconductor nanocrystals. The synthesis of TOPO and HDA-capped ZnSe nanoparticles were investigated in chapter three. Increasing the monomer concentration and temperature, led to a faster growth rate, increase in particle sizes and narrowing of the size distribution. XRD analysis show… Advisors/Committee Members: Revaprasadu, N (advisor).

Subjects/Keywords: selenide ions ; selenium powder

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APA (6^th Edition):

Oluwafemi, S. O. (2008). A new approach to the synthesis of selenium based nanoparticles . (Thesis). University of Zululand. Retrieved from http://hdl.handle.net/10530/67

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oluwafemi, Samuel Oluwatobi. “A new approach to the synthesis of selenium based nanoparticles .” 2008. Thesis, University of Zululand. Accessed June 19, 2019. http://hdl.handle.net/10530/67.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oluwafemi, Samuel Oluwatobi. “A new approach to the synthesis of selenium based nanoparticles .” 2008. Web. 19 Jun 2019.

Vancouver:

Oluwafemi SO. A new approach to the synthesis of selenium based nanoparticles . [Internet] [Thesis]. University of Zululand; 2008. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10530/67.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oluwafemi SO. A new approach to the synthesis of selenium based nanoparticles . [Thesis]. University of Zululand; 2008. Available from: http://hdl.handle.net/10530/67

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

27. Karren, Brady. THE EFFECT OF ORGANIC SELENIUM SUPPLEMENTATION AND DIETARY ENERGY MANIPULATION ON MARES AND THEIR FOALS: SELENIUM CONCENTRATIONS, GLUTATHIONE PEROXIDASE ACTIVITY, FOALING PARAMETERS AND FOAL PHYSICAL CHARACTERISTICS.

Degree: 2010, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2008-08-54

► Quarter Horse mares (n=28, 465-612 kg BW, 6-19 yrs of age) were used to investigate the effect of organic selenium (Se) supplementation (Selenosource, Diamond V… (more)

▼ Quarter Horse mares (n=28, 465-612 kg BW, 6-19 yrs of age) were used to investigate the effect of organic selenium (Se) supplementation (Selenosource, Diamond V Mills, Inc. Cedar Rapids, IA (SeM)) and DE manipulation on plasma, muscle, and colostrum Se concentrations, plasma glutathione peroxidase (Gsh-Px) activity, foaling parameters, and physical characteristics in mares and their foals. Mares were arranged in a 2x2 factorial with two levels of nutrition, pasture (100% NRC DE) or pasture plus grain (120% NRC DE) (fed at 0.75% BW (0.63 ppm Se)) and two levels of Se supplementation (0 or 0.3 mg/kg DM) equaling four treatment groups: pasture (P), pasture grain (PG), pasture grain Se (PGS), or pasture Se (PS). Mares were blocked by expected foaling date and randomly assigned to dietary treatment within block. Body condition score (BCS), BW, and rump fat (RF) were observed every 14 d beginning at d 0. Mare and foal plasma and muscle sampling began on d 0 (birth in foals). Plasma continued every 14 d and muscle every 28 d until parturition (d 56 in foals). Upon parturition, foaling parameters consisting of times: water break to birth, birth to placenta expulsion, foal standing, and nursing were recorded. Colostrum quality was determined via refractometer and colostrometer analysis, and placenta weight, foal birth weight, whither and hip height and body length were recorded. Maternal SeM supplementation influenced (P<0.05) mare and foal plasma, muscle and colostrum Se concentrations. Increased maternal DE influenced (P<0.05) mare and foal plasma and foal muscle Se, mare BW, BCS, and RF. However, mare muscle Se was unaffected (P>0.05) by DE. Mare and foal plasma Gsh-Px, foal physical characteristics, and foaling parameters were unaffected by treatment (P>0.05). Greater (P<0.02) colostrum refractometer values (Brix%) for P, PS mares were noted and PGS, P mares had shorter gestational lengths (nutrition x SeM interaction (P<0.05)). These data indicate that maternal DE manipulation and SeM supplementation influences mare and foal Se status, mare BW and colostrum quality (Brix%), but not plasma Gsh-Px activity. Additionally, nutrition and SeM supplementation may affect gestational length. However, despite treatments there was no difference in foaling parameters or foal physical characteristics. Advisors/Committee Members: Coverdale, Josie A. (advisor), Gibbs, Pete (committee member), Scott, Brett (committee member), Walzem, Rosemary (committee member).

Subjects/Keywords: horse; selenium; glutathione peroxidase

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APA (6^th Edition):

Karren, B. (2010). THE EFFECT OF ORGANIC SELENIUM SUPPLEMENTATION AND DIETARY ENERGY MANIPULATION ON MARES AND THEIR FOALS: SELENIUM CONCENTRATIONS, GLUTATHIONE PEROXIDASE ACTIVITY, FOALING PARAMETERS AND FOAL PHYSICAL CHARACTERISTICS. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2008-08-54

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karren, Brady. “THE EFFECT OF ORGANIC SELENIUM SUPPLEMENTATION AND DIETARY ENERGY MANIPULATION ON MARES AND THEIR FOALS: SELENIUM CONCENTRATIONS, GLUTATHIONE PEROXIDASE ACTIVITY, FOALING PARAMETERS AND FOAL PHYSICAL CHARACTERISTICS.” 2010. Thesis, Texas A&M University. Accessed June 19, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-2008-08-54.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karren, Brady. “THE EFFECT OF ORGANIC SELENIUM SUPPLEMENTATION AND DIETARY ENERGY MANIPULATION ON MARES AND THEIR FOALS: SELENIUM CONCENTRATIONS, GLUTATHIONE PEROXIDASE ACTIVITY, FOALING PARAMETERS AND FOAL PHYSICAL CHARACTERISTICS.” 2010. Web. 19 Jun 2019.

Vancouver:

Karren B. THE EFFECT OF ORGANIC SELENIUM SUPPLEMENTATION AND DIETARY ENERGY MANIPULATION ON MARES AND THEIR FOALS: SELENIUM CONCENTRATIONS, GLUTATHIONE PEROXIDASE ACTIVITY, FOALING PARAMETERS AND FOAL PHYSICAL CHARACTERISTICS. [Internet] [Thesis]. Texas A&M University; 2010. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2008-08-54.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karren B. THE EFFECT OF ORGANIC SELENIUM SUPPLEMENTATION AND DIETARY ENERGY MANIPULATION ON MARES AND THEIR FOALS: SELENIUM CONCENTRATIONS, GLUTATHIONE PEROXIDASE ACTIVITY, FOALING PARAMETERS AND FOAL PHYSICAL CHARACTERISTICS. [Thesis]. Texas A&M University; 2010. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2008-08-54

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

28. Zhou, Xiaodong. The effect of estrogen status on selenium metabolism in female rats.

Degree: PhD, Human Nutrition and Food Management, 2007, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985

► An association between male and female sex hormones and selenium status has been reported in animals and humans. These relationships may be important in the… (more)

▼ An association between male and female sex hormones and selenium status has been reported in animals and humans. These relationships may be important in the regulation of selenium metabolism and relative to the possible use of selenium as an adjunct for treatment of hormone-related diseases such as breast cancer. The purpose of the first study was to examine the effect of estrogen status on the absorption, tissue distribution and metabolism of orally administered 75Se-selenite. Female Sprague Dawley rats were bilaterally ovariectomized and implanted with either a placebo pellet (OVX) or pellet with estradiol (OVX+E2) at 7 weeks of age. At 12 weeks of age, 60 µCi of 75Se as selenite was orally administered to each rat. Blood and organs were collected 1, 3, 6, and 24h after dosing. Although apparent absorption of 75Se was independent of estrogen status, hormone associated differences of 75Se levels were noted in plasma, RBC, liver, heart, kidney, spleen, brain, and thymus at certain times. Plasma selenoprotein P (SelP) in OVX+E2 group contained a greater percentage of administered 75Se at 3, 6 and 24h after gavage compared to OVX group. 75Se in plasma glutathione peroxidase (GPx) also was greater in OVX+E2 compared to OVX group at 24h. The second aim was to investigate the effect of estrogen status on selenium status in tissues, and on hepatic mRNA levels of SelP and GPx1. Estrogen significantly increased selenium status as measured by selenium concentration and GPx activity in plasma, liver, and brain. Selenium concentration in RBC was also increased by estrogen treatment. Selenium status in kidney and heart was independent of estrogen treatment. Real-time RT-PCR analysis demonstrated that both hepatic SelP and GPx1 mRNA were significantly increased by estrogen treatment. In conclusion, these results suggest that estrogen status affects distribution of ingested selenium in tissue- and time-dependent manners. Expression of hepatic SelP and GPx was regulated by estrogen at both mRNA and protein levels. As SelP has been shown to function as a selenium transporter, estrogen regulation of SelP may play an important role in whole body metabolism of selenium. Advisors/Committee Members: Smith, Anne (Advisor).

Subjects/Keywords: selenium; estrogen; selenoproteins; ovariectomized rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhou, X. (2007). The effect of estrogen status on selenium metabolism in female rats. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985

Chicago Manual of Style (16^th Edition):

Zhou, Xiaodong. “The effect of estrogen status on selenium metabolism in female rats.” 2007. Doctoral Dissertation, The Ohio State University. Accessed June 19, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985.

MLA Handbook (7^th Edition):

Zhou, Xiaodong. “The effect of estrogen status on selenium metabolism in female rats.” 2007. Web. 19 Jun 2019.

Vancouver:

Zhou X. The effect of estrogen status on selenium metabolism in female rats. [Internet] [Doctoral dissertation]. The Ohio State University; 2007. [cited 2019 Jun 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985.

Council of Science Editors:

Zhou X. The effect of estrogen status on selenium metabolism in female rats. [Doctoral Dissertation]. The Ohio State University; 2007. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985

University of Alberta

29. Fortin, Barbra Linda. Selenium dynamics in Canadian Rocky Mountain lakes.

Degree: MS, Department of Biological Sciences, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/ng451j405

► I investigated, water, invertebrates and fishes from lakes in Banff National Park and Kananaskis Country, Alberta for selenium (Se), an element known to be toxic… (more)

Subjects/Keywords: fishes; selenium; mountain; food web

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fortin, B. L. (2010). Selenium dynamics in Canadian Rocky Mountain lakes. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/ng451j405

Chicago Manual of Style (16^th Edition):

Fortin, Barbra Linda. “Selenium dynamics in Canadian Rocky Mountain lakes.” 2010. Masters Thesis, University of Alberta. Accessed June 19, 2019. https://era.library.ualberta.ca/files/ng451j405.

MLA Handbook (7^th Edition):

Fortin, Barbra Linda. “Selenium dynamics in Canadian Rocky Mountain lakes.” 2010. Web. 19 Jun 2019.

Vancouver:

Fortin BL. Selenium dynamics in Canadian Rocky Mountain lakes. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2019 Jun 19]. Available from: https://era.library.ualberta.ca/files/ng451j405.

Council of Science Editors:

Fortin BL. Selenium dynamics in Canadian Rocky Mountain lakes. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/ng451j405

University of Aberdeen

30. Goh, Aik Han. Chronic gastro-oesophageal reflux disease (GORD) and low selenium status : a possible mechanism for the carcinogenesis of oesophageal adenocarcinoma.

Degree: PhD, 2013, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=206626 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600102

► Over the last three decades, there has been a sharp rise in the incidence of oesophageal adenocracinoma (OA) in the UK. The cause of this… (more)

▼ Over the last three decades, there has been a sharp rise in the incidence of oesophageal adenocracinoma (OA) in the UK. The cause of this rising trend remains unknown. Chronic symptomatic Gastro-Oesophageal Reflux Disease (GORD) has been associated with Barrett's oesophagus (BO), a premalignant stage of OA. The process how acid exposure drives the metaplasia-dysplasia-neoplasia sequence is not known. Oxidative stress plays vital role in carcinogenesis. Selenium is a trace metal element in our diet essential for anti-oxidant selenoproteins synthesis, such as glutathione peroxidases (GPxs). GPxs play a vital role in humans to fight oxidative stress. Epidemiological studies showed that high serum selenium levels are associated with a lower incidence of oesophageal and gastric cardia cancer. This thesis hypothesised that chronic GORD is an initiator of OA pathogenesis by exposing the lower oesophagus to chronic pulse acid, which results in radical oxygen species (ROS) production and oxidative stress damage. GORD patients with suboptimal selenium status are more susceptible to pulse-acid induced oxidative damage because of poor anti-oxidative defence system. The combination of pulse acid exposure and low selenium status potentially drives the OA pathogenesis. The study aims to investigate the effect of pulse-acid exposure, selenium status and its supplementation on cellular proliferation and apoptosis, key processes in carcinogenesis. The study also further investigated the potential pathways through which the pulse acid and low selenium could trigger the carcinogenesis. Ex vivo study was also conducted to examine the selenium status among BO and OA patients, including analysis of single nucleotide polymorphism (SNP) of GPx4 among these patients. The results showed that pulse-acid exposure increased cellular survival and suppressed apoptosis. This result was consistent with previous studies conducted by other researchers. Selenium supplementation at supra-optimal level (100 nM) was shown to potentially mitigate the proliferative effect induced by pulse-acid exposure. Pulse acid exposure was shown to induce ROS production in vitro. This could be mitigated by selenium supplementation. The mitigating effect was likely to be mediated by GPx1, and GPx4, selenoenzymes that are capable of reducing ROS. The study also revealed that apoptosis suppression by selenium supplementation was probably mediated by p53 tumour suppressor gene, but not via Bcl-2 protein. Ex vivo study results showed that OA patients have a 54% significant lower GPx4 mRNA expressions compared to the normal subjects, while the Barrett's subjects were in between OA and Normal. This is in line with the hypothesis that the severity of the disease is closely linked with the levels of anti-oxidant enzymes expression. Expectantly, patients with BO have higher, although not statistically significant, serum selenium compared to the control group. Single nucleotide polymorphism (SNP) of GPx4 could be an explanation for the reason OA and BO patients were unable to…

Subjects/Keywords: 610; Gastroesophageal reflux; Selenium; Esophagus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goh, A. H. (2013). Chronic gastro-oesophageal reflux disease (GORD) and low selenium status : a possible mechanism for the carcinogenesis of oesophageal adenocarcinoma. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=206626 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600102

Chicago Manual of Style (16^th Edition):

Goh, Aik Han. “Chronic gastro-oesophageal reflux disease (GORD) and low selenium status : a possible mechanism for the carcinogenesis of oesophageal adenocarcinoma.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed June 19, 2019. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=206626 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600102.

MLA Handbook (7^th Edition):

Goh, Aik Han. “Chronic gastro-oesophageal reflux disease (GORD) and low selenium status : a possible mechanism for the carcinogenesis of oesophageal adenocarcinoma.” 2013. Web. 19 Jun 2019.

Vancouver:

Goh AH. Chronic gastro-oesophageal reflux disease (GORD) and low selenium status : a possible mechanism for the carcinogenesis of oesophageal adenocarcinoma. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2019 Jun 19]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=206626 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600102.

Council of Science Editors:

Goh AH. Chronic gastro-oesophageal reflux disease (GORD) and low selenium status : a possible mechanism for the carcinogenesis of oesophageal adenocarcinoma. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=206626 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600102

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