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You searched for subject:(Selectivitat funcional). One record found.

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1. Martí Solano, Maria. Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism.

Degree: Departament de Ciències Experimentals i de la Salut, 2015, Universitat Pompeu Fabra

Deeper characterization of drugs targeting G protein-coupled receptors (GPCR)s has shown that their mechanisms of action can be more complex than previously thought. On the one hand, binding affinity analyses towards a panel of related receptors have revealed that most drugs have affinity for multiple targets. On the other, characterization of drug efficacy for different receptor pathways has made evident that some ligands can selectively activate particular pathways, thus acting as biased agonists. In this work, we used models derived from new experimental data on receptor 3D structure and pharmacology to rationalize the structural determinants of multi-target affinity and biased agonism for different GPCR ligands. This insight can help obtain new molecular probes to assess the importance of specific affinity and efficacy profiles for the treatment of complex diseases such as schizophrenia. Furthermore, it can set the basis for the rational design of new ligands exploiting different forms of selectivity and capable of separating therapeutic effects from side effects. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Pastor Maeso, Manuel (director), Selent, Jana (director), true (authorsendemail).

Subjects/Keywords: GPCR; Afinitat d’unió; Selectivitat funcional; Serotonina; Farmacoinformàtica; Binding affinity; Functional selectivity; Serotonin; Pharmacoinformatics; 615

…múltiples GPCRs i estudiar la seva selectivitat funcional. La informació obtinguda pot permetre… …diferents vies de senyalització va evidenciar que alguns f rmacs podien promoure selectivitat… …funcional. En aquesta tesi, s’han construït models a partir de noves dades estructurals i… …selectivitat i de discriminar entre efectes terapèutics i secundaris. viii Preface The last two… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Martí Solano, M. (2015). Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism. (Thesis). Universitat Pompeu Fabra. Retrieved from http://hdl.handle.net/10803/285964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Martí Solano, Maria. “Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism.” 2015. Thesis, Universitat Pompeu Fabra. Accessed January 29, 2020. http://hdl.handle.net/10803/285964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Martí Solano, Maria. “Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism.” 2015. Web. 29 Jan 2020.

Vancouver:

Martí Solano M. Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism. [Internet] [Thesis]. Universitat Pompeu Fabra; 2015. [cited 2020 Jan 29]. Available from: http://hdl.handle.net/10803/285964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martí Solano M. Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism. [Thesis]. Universitat Pompeu Fabra; 2015. Available from: http://hdl.handle.net/10803/285964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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