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Cleveland State University
1.
Popli, Labhesh.
AN ATTENTION BASED DEEP NEURAL NETWORK FOR VISUAL
QUESTIONANSWERING SYSTEM.
Degree: MSin Software Engineering, Washkewicz College of Engineering, 2019, Cleveland State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=csu1579015180507068
► With advances of internet computing and a great success of social media websites,internet is exploded with a huge number of digital images. Nowadays searching appropriateimages…
(more)
▼ With advances of internet computing and a great
success of social media websites,internet is exploded with a huge
number of digital images. Nowadays searching appropriateimages
directly through search engines and the web is trending. However,
automaticallyfinding images relevant to a textual query content
remains a very challenging task. VisualQuestion Answering (VQA)
system has emerged as a significant multidisciplinary
researchproblem. The research combines methodologies from the
different areas like naturallanguage processing, image recognition
and knowledge representation.The main challenges for developing
such a VQA system is to deal with the scalabilityof the solution
and handling features of the objects in vision and questions in a
naturallanguage simultaneously. Prior works have been done to
develop models for VQA byextracting and combining image features
using Convolution Neural Network (CNN) andtextual features using
Recurrent Neural Network (RNN). This thesis exploresmethodologies
to build a Visual Question Answering (VQA) system that can
automaticallyidentify and answer a question about the image
presented to it. The VQA system usesmethods of deep Residual
Network (ResNet), an advanced Convolution Neural Network(CNN) model
for image identification, and Long Short-Term Memory (LSTM)
networks,which is advanced form of Recurring Neural Network (RNN)
for Natural LanguageProcessing (NLP) to analyze a user-provided
question. Finally, the features from both an image and a user
question are combined to indicate an attention area to focus on to
identifyobjects in the area of the image in deep residual network,
to produce an answer in text.When evaluated on the well-known
challenging COCO data set and VQA 1.0 dataset,this system has
produced an accuracy of 59%, with a 12% increase when compared with
abaseline model without the attention-based technique and the
results also show comparableperformance to other existing
state-of-the-art attention-based approaches in the literature.The
quality and the accuracy of the method used in this research are
compared andanalyzed.
Advisors/Committee Members: Chung, Sunnie (Advisor).
Subjects/Keywords: Artificial Intelligence; Computer Engineering; Computer Science; Scientific Imaging
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APA (6th Edition):
Popli, L. (2019). AN ATTENTION BASED DEEP NEURAL NETWORK FOR VISUAL
QUESTIONANSWERING SYSTEM. (Masters Thesis). Cleveland State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=csu1579015180507068
Chicago Manual of Style (16th Edition):
Popli, Labhesh. “AN ATTENTION BASED DEEP NEURAL NETWORK FOR VISUAL
QUESTIONANSWERING SYSTEM.” 2019. Masters Thesis, Cleveland State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=csu1579015180507068.
MLA Handbook (7th Edition):
Popli, Labhesh. “AN ATTENTION BASED DEEP NEURAL NETWORK FOR VISUAL
QUESTIONANSWERING SYSTEM.” 2019. Web. 27 Feb 2021.
Vancouver:
Popli L. AN ATTENTION BASED DEEP NEURAL NETWORK FOR VISUAL
QUESTIONANSWERING SYSTEM. [Internet] [Masters thesis]. Cleveland State University; 2019. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1579015180507068.
Council of Science Editors:
Popli L. AN ATTENTION BASED DEEP NEURAL NETWORK FOR VISUAL
QUESTIONANSWERING SYSTEM. [Masters Thesis]. Cleveland State University; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1579015180507068

The Ohio State University
2.
Wavreille, Vincent Alain.
Correlation Between Histopathologic, Arthroscopic and
Magnetic Resonance Imaging Findings in Dogs with Medial Coronoid
Disease.
Degree: MS, Comparative and Veterinary Medicine, 2014, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1397060501
► Medial coronoid disease (MCD), a component of canine elbow dysplasia, is the most common cause of thoracic limb lameness in juvenile medium- to large-breed dogs.…
(more)
▼ Medial coronoid disease (MCD), a component of canine
elbow dysplasia, is the most common cause of thoracic limb lameness
in juvenile medium- to large-breed dogs. The goal of this study is
to describe the magnetic resonance
imaging (MRI), arthroscopic and
histopathological changes in dogs with medial coronoid disease and
to identify potential relationships between these findings.
Twenty-five diseased medial coronoid processes (MCP) were collected
from 19 dogs with a confirmed diagnosis of medial coronoid disease
that underwent surgical management with subtotal coronoid
ostectomy. A reference group of normal MCPs was harvested from 9
dogs that were euthanatized for reasons unrelated to elbow disease.
MCP specimens were evaluated by magnetic resonance
imaging (MRI)
using a novel grading scheme (all dogs), arthroscopy using a
modified Outerbridge scheme (affected dogs only) and histopathology
(all dogs). The common histopathologic findings were subchondral
microfractures, subchondral microfractures continuous with
cartilaginous fissures, moderate to severe hypercellularity of the
marrow space, trabecular bone necrosis and articular cartilage
degeneration. The severity of cartilage disease in the MCP was
moderate to severe in most of the specimens, even in cases with
minimal arthroscopic pathology. Three distinct patterns of bone
marrow lesion (BML) were identified adjacent to the MCP, but there
was no correlation between BML pattern and either histopathological
or arthroscopic findings. There was moderate correlation between
modified Outerbridge scores and MRI scores. No correlation was
identified between the histopathological changes and either MRI or
arthroscopic scores. There was no significant correlation between
the clinical scores and histopathological changes. Ongoing
improvements in the resolution of noninvasive
imaging techniques
will likely improve description and understanding of the MCP
disease in dogs.
Advisors/Committee Members: Allen, Matthew (Advisor).
Subjects/Keywords: Scientific Imaging; Veterinary Services; Surgery; Canine Elbow Dysplasia, MRI, Arthroscopy,
Histopathology
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MLA ·
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APA (6th Edition):
Wavreille, V. A. (2014). Correlation Between Histopathologic, Arthroscopic and
Magnetic Resonance Imaging Findings in Dogs with Medial Coronoid
Disease. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1397060501
Chicago Manual of Style (16th Edition):
Wavreille, Vincent Alain. “Correlation Between Histopathologic, Arthroscopic and
Magnetic Resonance Imaging Findings in Dogs with Medial Coronoid
Disease.” 2014. Masters Thesis, The Ohio State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1397060501.
MLA Handbook (7th Edition):
Wavreille, Vincent Alain. “Correlation Between Histopathologic, Arthroscopic and
Magnetic Resonance Imaging Findings in Dogs with Medial Coronoid
Disease.” 2014. Web. 27 Feb 2021.
Vancouver:
Wavreille VA. Correlation Between Histopathologic, Arthroscopic and
Magnetic Resonance Imaging Findings in Dogs with Medial Coronoid
Disease. [Internet] [Masters thesis]. The Ohio State University; 2014. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1397060501.
Council of Science Editors:
Wavreille VA. Correlation Between Histopathologic, Arthroscopic and
Magnetic Resonance Imaging Findings in Dogs with Medial Coronoid
Disease. [Masters Thesis]. The Ohio State University; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1397060501

University of Dayton
3.
Brookshire, Charles Thomas.
Illumination Recovery For Optical Microscopy.
Degree: MS(M.S.), Electrical Engineering, 2020, University of Dayton
URL: http://rave.ohiolink.edu/etdc/view?acc_num=dayton1588936914060945
► We propose a novel solution to the correction of illumination non-uniformity without removing the imaging sample.Calibration of the spatial illumination pattern in microscopy is challenging…
(more)
▼ We propose a novel solution to the correction of
illumination non-uniformity without removing the
imaging
sample.Calibration of the spatial illumination pattern in
microscopy is challenging due to the fact that the illumination
source is colocated with the objective lens and therefore cannot be
observed directly. Our proposed methodology overcomes this by
collecting three spatially translated images in a strategic way. We
prove that ``log-illumination pattern'' recovery can be
reformulated as a deconvolution of log-ratio of captured images,
and develop an efficient, noise-robust implementation. Experiments
with simulated and reflectance microscopy data verifies the
effectiveness of our proposed approach.
Advisors/Committee Members: Hirakawa, Keigo (Advisor).
Subjects/Keywords: Electrical Engineering; Scientific Imaging; Non-uniformity correction, Microscopy, Signal Processing,
Image Processing, Signal Recovery
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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Manager
APA (6th Edition):
Brookshire, C. T. (2020). Illumination Recovery For Optical Microscopy. (Masters Thesis). University of Dayton. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=dayton1588936914060945
Chicago Manual of Style (16th Edition):
Brookshire, Charles Thomas. “Illumination Recovery For Optical Microscopy.” 2020. Masters Thesis, University of Dayton. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=dayton1588936914060945.
MLA Handbook (7th Edition):
Brookshire, Charles Thomas. “Illumination Recovery For Optical Microscopy.” 2020. Web. 27 Feb 2021.
Vancouver:
Brookshire CT. Illumination Recovery For Optical Microscopy. [Internet] [Masters thesis]. University of Dayton; 2020. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=dayton1588936914060945.
Council of Science Editors:
Brookshire CT. Illumination Recovery For Optical Microscopy. [Masters Thesis]. University of Dayton; 2020. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=dayton1588936914060945

Florida International University
4.
Villacob, Raul A.
Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis.
Degree: MS, Chemistry, 2016, Florida International University
URL: https://digitalcommons.fiu.edu/etd/2561
;
10.25148/etd.FIDC000761
;
FIDC000761
► Secondary Ion Mass Spectrometry (SIMS) is a powerful technique for high spatial resolution chemical mapping and characterization of native surfaces. The use of massive…
(more)
▼ Secondary Ion Mass Spectrometry (SIMS) is a powerful technique for high spatial resolution chemical mapping and characterization of native surfaces. The use of massive cluster projectiles has been shown to extend the applicable mass range of SIMS and improve secondary ion yields 100 fold or beyond. These large projectiles however, present a challenge in terms of focusing due to the initial spatial and kinetic energy spreads inherent to their generation. In the present work, we describe the development and construction of a novel primary ion (PI) column employing a gold nanoparticle – liquid metal ion source (AuNP-LMIS) and the coupling to ultrahigh resolution mass spectrometers (e.g., Fourier Transform Ion Cyclotron Resonance Mass Spectrometer, FT-ICR MS) for accurate chemical characterization of complex biological surfaces. This work describes the ion dynamics, development and the experimental characterization of the AuNP-LMIS.
Advisors/Committee Members: Francisco A. Fernandez-Lima, Piero Gardinali, Jeffrey Joens.
Subjects/Keywords: Mass Spectrometry; Analytical Chemistry; Scientific Instrumentation Development; Focused Ion Beams; Surface Analysis; Mass Spectrometry Imaging; Nanoscale Imaging; Analytical Chemistry
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Villacob, R. A. (2016). Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis. (Thesis). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/2561 ; 10.25148/etd.FIDC000761 ; FIDC000761
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Villacob, Raul A. “Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis.” 2016. Thesis, Florida International University. Accessed February 27, 2021.
https://digitalcommons.fiu.edu/etd/2561 ; 10.25148/etd.FIDC000761 ; FIDC000761.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Villacob, Raul A. “Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis.” 2016. Web. 27 Feb 2021.
Vancouver:
Villacob RA. Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis. [Internet] [Thesis]. Florida International University; 2016. [cited 2021 Feb 27].
Available from: https://digitalcommons.fiu.edu/etd/2561 ; 10.25148/etd.FIDC000761 ; FIDC000761.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Villacob RA. Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis. [Thesis]. Florida International University; 2016. Available from: https://digitalcommons.fiu.edu/etd/2561 ; 10.25148/etd.FIDC000761 ; FIDC000761
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cleveland State University
5.
Ergin, Leanna N.
ENHANCED DATA REDUCTION, SEGMENTATION, AND SPATIAL
MULTIPLEXING METHODS FOR HYPERSPECTRAL IMAGING.
Degree: PhD, College of Sciences and Health Professions, 2017, Cleveland State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=csu1501871494997272
► A hyperspectral image is a dataset consisting of both spectra and spatial information. It can be thought of either as a full spectrum taken at…
(more)
▼ A hyperspectral image is a dataset consisting of both
spectra and spatial information. It can be thought of either as a
full spectrum taken at many pixel locations on a sample or many
images of the same sample, each at a different wavelength. In
recent decades, hyperspectral
imaging has become a routine
analytical method due to rapid advances in instrumentation and
technique. Advances such as the speed of data acquisition, improved
signal-to-noise-ratio, improved spatial resolution, and
miniaturization of the instrumentation have all occurred, making
chemical
imaging methods more robust and more widely used. The work
presented here deals with three issues in the field of
hyperspectral
imaging: unassisted data processing that is
chemically meaningful and allows for subsequent chemometric
analyses, visualization of the data that utilizes the full
colorspace of modern red, green, blue (RGB) displays, and data
collection with improved signal-to-noise ratios and comparably
short acquisition times. Hyperspectral image data processing is a
fundamental challenge in the field. There is a need for reliable
processing techniques that can operate on the large amount of data
in a hyperspectral image dataset. Because of the large quantity of
data, currently-used methods for data processing are problematic
because of how time-consuming and calculation-intensive they are or
because of increased error that is observed in the less-intensive
methods. The work presented here includes a user-unassisted method
for rapidly generating chemical-based image contrast from
hyperspectral image data. Our method, reduction of spectral images
(ROSI), is an effective hyperspectral image processing method. A
full theoretical description of the method is given along with
performance metrics. The description has been generalized to work
with any number of wavelength dimensions and spectra. A concise
protocol is put forth that will enable other researchers to utilize
this method by following a short, simple list of steps. ROSI can
also be used as a data reduction method, as it achieves a threshold
information density in the spectral dimension for all image pixels.
ROSI results are suitable for subsequent data analysis enabling
ROSI to be performed alone or as a preprocessing data reduction
step. This research also improves upon a spatially-multiplexed
Raman
imaging system based on the digital micromirror device (DMD).
The system provides signal-to-noise ratio enhancement while
maintaining laser powers below the damage threshold of the sample
and comparably short acquisition times. In the work presented here,
the spatial resolution of the DMD imager has been improved such
that features with a width of 2.19µm could be resolved, whereas the
previous limit was 7.81µm.
Advisors/Committee Members: Turner, John (Advisor).
Subjects/Keywords: Chemistry; Analytical Chemistry; Scientific Imaging; hyperspectral imaging; chemical imaging; data reduction; image segmentation; direction cosine; principal component analysis; PCA; reduction of spectral angle; ROSI; digital micromirror device; spatial multiplexing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ergin, L. N. (2017). ENHANCED DATA REDUCTION, SEGMENTATION, AND SPATIAL
MULTIPLEXING METHODS FOR HYPERSPECTRAL IMAGING. (Doctoral Dissertation). Cleveland State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=csu1501871494997272
Chicago Manual of Style (16th Edition):
Ergin, Leanna N. “ENHANCED DATA REDUCTION, SEGMENTATION, AND SPATIAL
MULTIPLEXING METHODS FOR HYPERSPECTRAL IMAGING.” 2017. Doctoral Dissertation, Cleveland State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=csu1501871494997272.
MLA Handbook (7th Edition):
Ergin, Leanna N. “ENHANCED DATA REDUCTION, SEGMENTATION, AND SPATIAL
MULTIPLEXING METHODS FOR HYPERSPECTRAL IMAGING.” 2017. Web. 27 Feb 2021.
Vancouver:
Ergin LN. ENHANCED DATA REDUCTION, SEGMENTATION, AND SPATIAL
MULTIPLEXING METHODS FOR HYPERSPECTRAL IMAGING. [Internet] [Doctoral dissertation]. Cleveland State University; 2017. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1501871494997272.
Council of Science Editors:
Ergin LN. ENHANCED DATA REDUCTION, SEGMENTATION, AND SPATIAL
MULTIPLEXING METHODS FOR HYPERSPECTRAL IMAGING. [Doctoral Dissertation]. Cleveland State University; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1501871494997272
6.
Heise, Erich A.
Development and Commercialization of Functional,
Non-Invasive Retinal Imaging Device Utilizing Quantification of
Flavoprotein Fluorescence for the Diagnosis and Monitoring of
Retinal Disease.
Degree: MSs, Biology, 2016, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1458921113
► Diabetes and its related complications are becoming increasingly more prevalent in the United States and other developed countries. Additionally, an increasingly earlier age of onset…
(more)
▼ Diabetes and its related complications are becoming
increasingly more prevalent in the United States and other
developed countries. Additionally, an increasingly earlier age of
onset results in more complications, such as diabetic retinopathy,
leading to increased annual medical costs and poorer quality of
life. Therefore, the ability to rapidly and non-invasively detect
diabetes and other retinal diseases at the earliest stages is
critical to saving patients’ vision and improving their overall
quality of life. Retinal metabolic analysis, a measure that the
detects the fluorescence of flavoproteins critical to ATP
generation, allows ophthalmologists and optometrists to identity
retinal diseases earlier in the disease process and intervene
before irreversible tissue damage and loss of visual acuity
occurs.
Advisors/Committee Members: Cullis, Christopher (Advisor).
Subjects/Keywords: Scientific Imaging; Biochemistry; Biology; Biomedical Engineering; Biophysics; Cellular Biology; Entrepreneurship; Health; Medical Imaging; Ophthalmology; flavoprotein fluorescence; retinal metabolic analysis; OcuSciences; functional retinal imager; biotechnology; retinal imaging; FPF
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Heise, E. A. (2016). Development and Commercialization of Functional,
Non-Invasive Retinal Imaging Device Utilizing Quantification of
Flavoprotein Fluorescence for the Diagnosis and Monitoring of
Retinal Disease. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1458921113
Chicago Manual of Style (16th Edition):
Heise, Erich A. “Development and Commercialization of Functional,
Non-Invasive Retinal Imaging Device Utilizing Quantification of
Flavoprotein Fluorescence for the Diagnosis and Monitoring of
Retinal Disease.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1458921113.
MLA Handbook (7th Edition):
Heise, Erich A. “Development and Commercialization of Functional,
Non-Invasive Retinal Imaging Device Utilizing Quantification of
Flavoprotein Fluorescence for the Diagnosis and Monitoring of
Retinal Disease.” 2016. Web. 27 Feb 2021.
Vancouver:
Heise EA. Development and Commercialization of Functional,
Non-Invasive Retinal Imaging Device Utilizing Quantification of
Flavoprotein Fluorescence for the Diagnosis and Monitoring of
Retinal Disease. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1458921113.
Council of Science Editors:
Heise EA. Development and Commercialization of Functional,
Non-Invasive Retinal Imaging Device Utilizing Quantification of
Flavoprotein Fluorescence for the Diagnosis and Monitoring of
Retinal Disease. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1458921113

University of Akron
7.
Narayan, Chaya.
Polarimetric Stokes Imaging for the Detection of Tumor
Margins and Segmentation.
Degree: MSin Engineering, Electrical Engineering, 2013, University of Akron
URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1386785379
► Cancer is the second most common cause of death in the US and is responsible for about 25% of the deaths according to the American…
(more)
▼ Cancer is the second most common cause of death in the
US and is responsible for about 25% of the deaths according to the
American Cancer Society. There is a need for quick and accurate
detection of tumors in a real time automated environment without
the delays associated with laboratory procedures. There is also a
need to identify the exact location and extent of the tumor tissues
so that surgeries would not only be more effective but also as
minimally invasive as possible. The purpose of this study was to
distinguish the margins between healthy and cancerous tissues on
slides containing samples of mice brain tumor through the use of
polarimetric stokes
imaging techniques. Comparison between the
cancerous and healthy tissue portions from polarimetric
imaging was
expected to provide better distinction of the two areas and the
margin between them.The experiments were conducted with a broadband
white light source and the data was recorded using a circular
polarized rotating retarder system in transmission mode. The
samples used were unstained sliced sections of mice brain prepared
using standard procedures. The images were saved with an optical
camera that was impartial to color or fluorescence properties of
the samples. The Stokes parameter images of the samples were
computed through the Fourier analysis method. The images for Degree
of Polarization (DOP), Degree of Linear Polarization (DOLP) and
Degree of Circular Polarization (DOCP) were also computed. The
images thus generated were segmented and post-processed to analyze
properties such as texture and tissue density. Additionally, small
selections of tumor and healthy tissue having the same pixel area
were chosen from the Stokes images for further statistical
analyses.The statistical findings from this study showed that image
features of tumor tissue had lower variance values to the various
degrees of polarization when compared to that of normal tissue.
This meant that the surface of tumors were more densely packed and
more uniform than healthy tissue thus enabling successful
segmentation, thereby proving the expectation that polarimetric
stokes
imaging was an efficient and robust tool in the detection of
margins.
Advisors/Committee Members: Giakos, George C. (Advisor).
Subjects/Keywords: Biology; Biomedical Engineering; Biomedical Research; Electrical Engineering; Engineering; Experiments; Health; Health Care; Health Sciences; Optics; Pathology; Scientific Imaging; Technology; Polarimetry, Stokes Imaging, Cancer margins, Segmentation,
Polarimetric Imaging
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Narayan, C. (2013). Polarimetric Stokes Imaging for the Detection of Tumor
Margins and Segmentation. (Masters Thesis). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1386785379
Chicago Manual of Style (16th Edition):
Narayan, Chaya. “Polarimetric Stokes Imaging for the Detection of Tumor
Margins and Segmentation.” 2013. Masters Thesis, University of Akron. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=akron1386785379.
MLA Handbook (7th Edition):
Narayan, Chaya. “Polarimetric Stokes Imaging for the Detection of Tumor
Margins and Segmentation.” 2013. Web. 27 Feb 2021.
Vancouver:
Narayan C. Polarimetric Stokes Imaging for the Detection of Tumor
Margins and Segmentation. [Internet] [Masters thesis]. University of Akron; 2013. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1386785379.
Council of Science Editors:
Narayan C. Polarimetric Stokes Imaging for the Detection of Tumor
Margins and Segmentation. [Masters Thesis]. University of Akron; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1386785379

McMaster University
8.
Moghadas, Maryam.
Type-Safety for Inverse Imaging Problems.
Degree: MSc, 2012, McMaster University
URL: http://hdl.handle.net/11375/12487
► This thesis gives a partial answer to the question: “Can type systems detect modeling errors in scientific computing, particularly for inverse problems derived from…
(more)
▼ This thesis gives a partial answer to the question: “Can type systems detect modeling errors in scientific computing, particularly for inverse problems derived from physical models?” by considering, in detail, the major aspects of inverse problems in Magnetic Resonance Imaging (MRI). We define a type-system that can capture all correctness properties for MRI inverse problems, including many properties that are not captured with current type-systems, e.g., frames of reference. We implemented a type-system in the Haskell language that can capture the errors arising in translating a mathe- matical model into a linear or nonlinear system, or alternatively into an objective function. Most models are (or can be approximated by) linear transformations, and we demonstrate the feasibility of capturing their correctness at the type level using what is arguably the most difficult case, the (discrete) Fourier transformation (DFT). By this, we mean that we are able to catch, at compile time, all known errors in ap- plying the DFT. The first part of this thesis describes the Haskell implementation of vector size, physical units, frame of reference, and so on required in the mathemat- ical modelling of inverse problems without regularization. To practically solve most inverse problems, especially those including noisy data or ill-conditioned systems, one must use regularization. The second part of this thesis addresses the question of defining new regularizers and identifying existing regularizers the correctness of which (in our estimation) can be formally verified at the type level. We describe such Bayesian regularization schemes based on probability theory, and describe a novel simple regularizer of this type. We leave as future work the formalization of such regularizers.
Master of Science (MSc)
Advisors/Committee Members: Anand, Christopher, Kahl, Wolfram, Computing and Software.
Subjects/Keywords: type-safety; Inverse Imaging Problem; Type Level Programming; Haskell; Regularization; formalization; Numerical Analysis and Scientific Computing; Programming Languages and Compilers; Numerical Analysis and Scientific Computing
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APA (6th Edition):
Moghadas, M. (2012). Type-Safety for Inverse Imaging Problems. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/12487
Chicago Manual of Style (16th Edition):
Moghadas, Maryam. “Type-Safety for Inverse Imaging Problems.” 2012. Masters Thesis, McMaster University. Accessed February 27, 2021.
http://hdl.handle.net/11375/12487.
MLA Handbook (7th Edition):
Moghadas, Maryam. “Type-Safety for Inverse Imaging Problems.” 2012. Web. 27 Feb 2021.
Vancouver:
Moghadas M. Type-Safety for Inverse Imaging Problems. [Internet] [Masters thesis]. McMaster University; 2012. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11375/12487.
Council of Science Editors:
Moghadas M. Type-Safety for Inverse Imaging Problems. [Masters Thesis]. McMaster University; 2012. Available from: http://hdl.handle.net/11375/12487
9.
Fennimore, Todd F.
Understanding change in medicine and the biomedical
sciences: Modeling change as interactions among flows with arrow
diagrams.
Degree: MA, Cognitive Linguistics, 2011, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1307626543
► Building on Aristotle’s analysis, this thesis starts with a definition of change as the result of a network of influences operating to shape a particular…
(more)
▼ Building on Aristotle’s analysis, this thesis starts
with a definition of change as the result of a network of
influences operating to shape a particular outcome in manifesting a
potential. It argues that change can be modeled as an interaction
among flows, and that arrow diagrams are effective tools for such
modeling. The thesis demonstrates how the phenomenology, ontology,
and dynamics of change are prompted in the interpretation of arrow
diagrams. A typology is presented that emerged from a corpus
analysis of arrow diagrams sampled from medical and biomedical
journals. In Chapter 2, the typology is applied to the analyses of
arrow diagrams from this corpus. In Chapter 3, I propose that a
systematic treatment of ways in which arrow diagramming are used to
model change can become the basis for a new field that I dub
“fluxemics.” Moving forward, this idea will be developed
mathematically and tested empirically.
Advisors/Committee Members: Brandt, Per Aage (Advisor).
Subjects/Keywords: Scientific Imaging; Systems Science; scientific reasoning; explanation; diagramming; cognitive science; modeling of change
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fennimore, T. F. (2011). Understanding change in medicine and the biomedical
sciences: Modeling change as interactions among flows with arrow
diagrams. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1307626543
Chicago Manual of Style (16th Edition):
Fennimore, Todd F. “Understanding change in medicine and the biomedical
sciences: Modeling change as interactions among flows with arrow
diagrams.” 2011. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1307626543.
MLA Handbook (7th Edition):
Fennimore, Todd F. “Understanding change in medicine and the biomedical
sciences: Modeling change as interactions among flows with arrow
diagrams.” 2011. Web. 27 Feb 2021.
Vancouver:
Fennimore TF. Understanding change in medicine and the biomedical
sciences: Modeling change as interactions among flows with arrow
diagrams. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2011. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1307626543.
Council of Science Editors:
Fennimore TF. Understanding change in medicine and the biomedical
sciences: Modeling change as interactions among flows with arrow
diagrams. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2011. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1307626543

Rochester Institute of Technology
10.
Park, Sung Ho.
Rendering non-pictorial (Scientific) high dynamic range images.
Degree: School of Photographic Arts and Sciences (CIAS), 2004, Rochester Institute of Technology
URL: https://scholarworks.rit.edu/theses/5240
► In recent years, the graphics community is seeing an increasing demand for the capture and usage of high-dynamic-range (HDR) images. Since the production of HDR…
(more)
▼ In recent years, the graphics community is seeing an increasing demand for the capture
and usage of high-dynamic-range (HDR) images. Since the production of HDR imagery
is not solely the domain of the visualization of real life or computer generated scenes,
novel techniques are also required for imagery captured from non-visual sources such as
remote sensing, medical
imaging, astronomical
imaging, etc. This research proposes to
integrate the techniques used for the display of high-dynamic-range pictorial imagery for
the practical visualization of non-pictorial (
scientific) imagery for data mining and
interpretation.
Nine algorithms were utilized to overcome the problem associated with rendering the
high-dynamic-range image data to low-dynamic-range display devices, and the results
were evaluated using a psychophysical experiment. Two paired-comparison experiments
and a target detection experiment were performed. Paired-comparison results indicate
that the Zone System performs the best on average and the Local Color Correction
method performs the worst. The results show that the performance of different encoding
schemes depend on the type of data being visualized. The correlation between the
preference and
scientific usefulness judgments (R2
= 0.31) demonstrates that observers
tend to use different criteria when judging the
scientific usefulness versus image
preference. The experiment was conducted using observers with expertise (Radiologists)
for the Medical image to further elucidate the success of HDR rendering on these data.
The results indicated that both Radiologists and Non-radiologists tend to use similar
criteria regardless of their experience and expertise when judging the usefulness of
rendered images. A target detection experiment was conducted to measure the
detectability of an embedded noise target in the Medical image to demonstrate the effect
of the tone mapping operators on target detection. The result of the target detection
experiment illustrated that the detectability of targets the image is greatly influenced by
the rendering algorithm due to the inherent differences in tone mapping among the
algorithms.
Advisors/Committee Members: Montag, Ethan.
Subjects/Keywords: High-dynamic-range images; Imaging science; Scientific use
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Park, S. H. (2004). Rendering non-pictorial (Scientific) high dynamic range images. (Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/5240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Park, Sung Ho. “Rendering non-pictorial (Scientific) high dynamic range images.” 2004. Thesis, Rochester Institute of Technology. Accessed February 27, 2021.
https://scholarworks.rit.edu/theses/5240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Park, Sung Ho. “Rendering non-pictorial (Scientific) high dynamic range images.” 2004. Web. 27 Feb 2021.
Vancouver:
Park SH. Rendering non-pictorial (Scientific) high dynamic range images. [Internet] [Thesis]. Rochester Institute of Technology; 2004. [cited 2021 Feb 27].
Available from: https://scholarworks.rit.edu/theses/5240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Park SH. Rendering non-pictorial (Scientific) high dynamic range images. [Thesis]. Rochester Institute of Technology; 2004. Available from: https://scholarworks.rit.edu/theses/5240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
11.
Gaillard, Maxence.
Les images du cerveau : epistémologie de l'usage de l'imagerie cérébrale en sciences cognitives : Images of brain, philosophy of brain imaging in cognitive science.
Degree: Docteur es, Philosophie, 2015, Lyon, École normale supérieure
URL: http://www.theses.fr/2015ENSL1023
► Cette thèse d’épistémologie et d’histoire des sciences cognitives est consacrée à son niveau le plus général au problème de l’instrument scientifique, parent pauvre de la…
(more)
▼ Cette thèse d’épistémologie et d’histoire des sciences cognitives est consacrée à son niveau le plus général au problème de l’instrument scientifique, parent pauvre de la réflexion sur l’investigation scientifique, et se concentre à titre particulier sur le développement des techniques d’imagerie cérébrale fonctionnelle et leur introduction dans le domaine cognitif au cours des années 1980-1990. Un choix motivé notamment par la nouveauté et l’importance de ce nouvel instrument, dont l’émergence est régulièrement comparée à celle du télescope au moment de la Révolution scientifique du XVIIe siècle. La première partie est ainsi consacrée à une analyse générale de l’instrument scientifique et des problèmes essentiels qu’il soulève. Elle propose un certain nombre d’hypothèses en réponse, et en examine les enjeux théoriques. La deuxième partie défend une interprétation historique de l’émergence des deux technologies d’imagerie fonctionnelle que sont la tomographie par émission de positons et l’imagerie par résonance magnétique fonctionnelle. En reprenant dans le détail certains éléments d’invention et de diffusion de ces techniques, elle montre notamment l’intrication des procédures de validation des instruments et des divers mécanismes scientifiques et sociétaux qui poussent à les développer puis à les utiliser. A la lumière des analyses théoriques et générales de la première, et sur la base de l’interprétation historique de la seconde, la troisième partie est dédiée à l’examen des implications de ces nouvelles technologies d’imagerie sur l’évolution du champ des sciences cognitives et de la reprise de leurs résultats dans d’autres domaines, tant scientifiques que technologiques ou pratiques. A ce double égard, elle défend la thèse générale que l’introduction de l’imagerie agit beaucoup moins comme un facteur de résolution de certaines questions que comme un facteur de déplacement de la problématique et de l’impact théorique et sociétal des sciences cognitives.
At a general level, this dissertation in philosophy and history of cognitive science is devoted to the underestimated problem of scientific instruments. It is focused on some functional brain imaging techniques introduced in the field of cognitive studies during the 1980’s and 1990’s, the impact of such new technologies being sometimes compared to an instrumental revolution, in a way similar to the impact of the invention of the telescope on post-Galilean astronomy. The first part consists in a philosophical and historical analysis of the notion of scientific instrument. In this regard, some issues are raises and some hypotheses are formulated. The second part presents an interpretation of the historical emergence of Positron Emission Tomography and functional Magnetic Resonance Imaging. Dealing with details of the invention and circulation of those techniques, it shows in particular the entanglement of the validation procedures of instruments with the various scientific and societal mechanisms driving to their development and use. Taking its roots in the…
Advisors/Committee Members: Roy, Jean-Michel (thesis director).
Subjects/Keywords: Instrument scientifique; Expérimentation; Imagerie cérébrale; Sciences cognitives; Neurosciences; TEP; IRMf; Scientific instruments; Experimentation; Brain imaging; Cognitive science; Neuroscience; PET; FMRI
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gaillard, M. (2015). Les images du cerveau : epistémologie de l'usage de l'imagerie cérébrale en sciences cognitives : Images of brain, philosophy of brain imaging in cognitive science. (Doctoral Dissertation). Lyon, École normale supérieure. Retrieved from http://www.theses.fr/2015ENSL1023
Chicago Manual of Style (16th Edition):
Gaillard, Maxence. “Les images du cerveau : epistémologie de l'usage de l'imagerie cérébrale en sciences cognitives : Images of brain, philosophy of brain imaging in cognitive science.” 2015. Doctoral Dissertation, Lyon, École normale supérieure. Accessed February 27, 2021.
http://www.theses.fr/2015ENSL1023.
MLA Handbook (7th Edition):
Gaillard, Maxence. “Les images du cerveau : epistémologie de l'usage de l'imagerie cérébrale en sciences cognitives : Images of brain, philosophy of brain imaging in cognitive science.” 2015. Web. 27 Feb 2021.
Vancouver:
Gaillard M. Les images du cerveau : epistémologie de l'usage de l'imagerie cérébrale en sciences cognitives : Images of brain, philosophy of brain imaging in cognitive science. [Internet] [Doctoral dissertation]. Lyon, École normale supérieure; 2015. [cited 2021 Feb 27].
Available from: http://www.theses.fr/2015ENSL1023.
Council of Science Editors:
Gaillard M. Les images du cerveau : epistémologie de l'usage de l'imagerie cérébrale en sciences cognitives : Images of brain, philosophy of brain imaging in cognitive science. [Doctoral Dissertation]. Lyon, École normale supérieure; 2015. Available from: http://www.theses.fr/2015ENSL1023
12.
Lee, Sang Hyeb.
Computational Framework for Small Animal SPECT Imaging: Simulation and Reconstruction.
Degree: 2015, University of Tennessee – Knoxville
URL: https://trace.tennessee.edu/utk_graddiss/3346
► Small animal Single Photon Emission Computed Tomography (SPECT) has been an invaluable asset in biomedical science since this non-invasive imaging technique allows the longitudinal studies…
(more)
▼ Small animal Single Photon Emission Computed Tomography (SPECT) has been an invaluable asset in biomedical science since this non-invasive imaging technique allows the longitudinal studies of animal models of human diseases. However, the image degradation caused by non-stationary collimator-detector response and single photon emitting nature of SPECT makes it difficult to provide a quantitative measure of 3D radio-pharmaceutical distribution inside the patient. Moreover, this problem exacerbates when an intra-peritoneal X-ray contrast agent is injected into a mouse for low-energy radiotracers.
In this dissertation, we design and develop a complete computational framework for the entire SPECT scan procedure from the radio-pharmaceutical injection, image acquisition, attenuation and scatter correction, and to the image reconstruction. Using this framework, we solve several challenging problems in small animal SPECT imaging. In particular, we perform an in-depth analysis of photon attenuation and scatter in small SPECT imaging and evaluate the performance of correction methods under various imaging circumstances in terms of image quality and computational complexity. Furthermore, we propose various techniques to accelerate correction methods using computational accelerators. This research also implements and validates a solution for solving the cross-talk contamination problem in I-123 and I-125 by using the ratio of detected low and high energy I-123 activity to separate the mixed low energy I-123 and I-125 activities using our simulation framework. Iterative reconstruction methods produce an accurate image using an accurate system matrix model of the image acquisition process at the expense of computational time. This research examines and proposes various techniques for accelerating the analytic system matrix generation for 3D SPECT.
Subjects/Keywords: Medical Imaging; SPECT; Reconstruction; Simulation; Attenuation and Scatter Correction; Computer Engineering; Nuclear; Numerical Analysis and Scientific Computing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, S. H. (2015). Computational Framework for Small Animal SPECT Imaging: Simulation and Reconstruction. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/3346
Chicago Manual of Style (16th Edition):
Lee, Sang Hyeb. “Computational Framework for Small Animal SPECT Imaging: Simulation and Reconstruction.” 2015. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed February 27, 2021.
https://trace.tennessee.edu/utk_graddiss/3346.
MLA Handbook (7th Edition):
Lee, Sang Hyeb. “Computational Framework for Small Animal SPECT Imaging: Simulation and Reconstruction.” 2015. Web. 27 Feb 2021.
Vancouver:
Lee SH. Computational Framework for Small Animal SPECT Imaging: Simulation and Reconstruction. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2015. [cited 2021 Feb 27].
Available from: https://trace.tennessee.edu/utk_graddiss/3346.
Council of Science Editors:
Lee SH. Computational Framework for Small Animal SPECT Imaging: Simulation and Reconstruction. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2015. Available from: https://trace.tennessee.edu/utk_graddiss/3346

University of Manchester
13.
Sandoval Olive, Mario.
6DoF Mouse Integration for Scientific and Medical
Visualisation.
Degree: 2016, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:296193
► With advances in medical imaging over the years, medical diagnosis, especially X-ray based examinations and ultrasonography, have become increasingly reliant on a range of 3D…
(more)
▼ With advances in medical
imaging over the years,
medical diagnosis, especially X-ray based examinations and
ultrasonography, have become increasingly reliant on a range of 3D
digital
imaging data systems for navigation, reference, diagnosis
and documentation. Medical
imaging, used in the field of
Scientific
Visualisation (SV), is used to explore results and extract meaning
from complex multi-dimensional visual representations of the
interior of a human body for clinical analysis and medical
intervention. The implication of this is that an effective and
intuitive input device is needed that allows the information
entered into the computer can be encompassed to different
imaging
modalities and processes for diagnostic and treatment purposes.
Traditional input devices such as the computer mouse are limited to
explore these data sets, creating difficulties and inefficiencies,
which in turn can entail potential medical complications as, in
public health and preventive medicine as well as in both curative
and palliative care, effective decisions depend on correct
diagnoses. Therefore, using this principle this work investigates
human-computer interactions in relation to a specific Six Degree of
Freedom (6DoF) input device called the Wing and reports the results
of a brief satisfaction questionnaire to analyse the effectiveness
and intuitiveness of this device in 3D visualisation volume
software for SV and medical
imaging, the mental processes involved
in performing control actions on this device and the effect of
proprioception of the test users. Finally, it concludes with a
discussion of the evolution of the Wing based on the results and
new possibilities for 3D interactions in other
fields.
Advisors/Committee Members: TURNER, MARTIN MJ, Morris, Tim, Turner, Martin.
Subjects/Keywords: Input Devices; 3D Volumetric Visualisation; Degrees of Freedom; Scientific Visualisation; Medical Imaging; Virtual Reality; 6DoF; Visualisation Volume Software
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sandoval Olive, M. (2016). 6DoF Mouse Integration for Scientific and Medical
Visualisation. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:296193
Chicago Manual of Style (16th Edition):
Sandoval Olive, Mario. “6DoF Mouse Integration for Scientific and Medical
Visualisation.” 2016. Doctoral Dissertation, University of Manchester. Accessed February 27, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:296193.
MLA Handbook (7th Edition):
Sandoval Olive, Mario. “6DoF Mouse Integration for Scientific and Medical
Visualisation.” 2016. Web. 27 Feb 2021.
Vancouver:
Sandoval Olive M. 6DoF Mouse Integration for Scientific and Medical
Visualisation. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Feb 27].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:296193.
Council of Science Editors:
Sandoval Olive M. 6DoF Mouse Integration for Scientific and Medical
Visualisation. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:296193

McMaster University
14.
Emond, Patrick D.
Bone Erosion Measurement in Subjects with Rheumatoid Arthritis Using Magnetic Resonance Imaging.
Degree: PhD, 2012, McMaster University
URL: http://hdl.handle.net/11375/11789
► Rheumatoid arthritis (RA) is a systemic disease that can affect the nervous system, lungs, heart, skin, reticuloendothelium and joints. Currently, the gold-standard measurement for…
(more)
▼ Rheumatoid arthritis (RA) is a systemic disease that can affect the nervous system, lungs, heart, skin, reticuloendothelium and joints. Currently, the gold-standard measurement for tracking the progression of the disease involves a semi-quantitative assessment of bone erosion, bone marrow edema and synovitis, as seen in magnetic resonance (MR) images, by a musculoskeletal radiologist. The work presented in this thesis identifies how computer automation can be used to quantify bone erosion volumes in MR images without a radiologists' expert and time consuming intervention. A new semi-automated hybrid segmentation algorithm that combines two established techniques: region growing and level-set segmentation, is described and evaluated for use in a clinical setting. A total of 40 participants with RA were scanned using a 1-Tesla peripheral MR scanner. Eight of the participant scans were used to train the algorithm with the remaining used to determine the accuracy, precision, and speed of the technique. The reproducibility of the hybrid algorithm and that of manual segmentation were defined in terms of intra-class correlation coefficients (ICCs). Both techniques were equally precise with ICC values greater than 0.9. According to a least squares fit between erosion volumes obtained by the hybrid algorithm with those obtained from manual tracings drawn by a radiologist, the former was found to be highly accurate ( m=1.030, b=1.385: r-squared=0.923). The hybrid algorithm was significantly faster than manual segmentation, which took two to four times longer to complete. In conclusion, computer automation shows promise as a means to quantitatively assess bone erosion volumes. The new hybrid segmentation algorithm described in this thesis could be used in a clinical setting to track the progression of RA and to evaluate the effectiveness of treatment.
Doctor of Philosophy (PhD)
Advisors/Committee Members: Gordon, Christopher, Medical Physics.
Subjects/Keywords: medical imaging; magnetic resonance imaging; rheumatoid arthritis; bone erosion; segmentation; Graphics and Human Computer Interfaces; Numerical Analysis and Scientific Computing; Other Physics; Radiology; Rheumatology; Graphics and Human Computer Interfaces
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Emond, P. D. (2012). Bone Erosion Measurement in Subjects with Rheumatoid Arthritis Using Magnetic Resonance Imaging. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/11789
Chicago Manual of Style (16th Edition):
Emond, Patrick D. “Bone Erosion Measurement in Subjects with Rheumatoid Arthritis Using Magnetic Resonance Imaging.” 2012. Doctoral Dissertation, McMaster University. Accessed February 27, 2021.
http://hdl.handle.net/11375/11789.
MLA Handbook (7th Edition):
Emond, Patrick D. “Bone Erosion Measurement in Subjects with Rheumatoid Arthritis Using Magnetic Resonance Imaging.” 2012. Web. 27 Feb 2021.
Vancouver:
Emond PD. Bone Erosion Measurement in Subjects with Rheumatoid Arthritis Using Magnetic Resonance Imaging. [Internet] [Doctoral dissertation]. McMaster University; 2012. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11375/11789.
Council of Science Editors:
Emond PD. Bone Erosion Measurement in Subjects with Rheumatoid Arthritis Using Magnetic Resonance Imaging. [Doctoral Dissertation]. McMaster University; 2012. Available from: http://hdl.handle.net/11375/11789

Texas Medical Center
15.
Ahmad, Moiz.
Design and Optimization of Four-dimensional Cone-beam Computed Tomography in Image-guided Radiation Therapy.
Degree: PhD, 2012, Texas Medical Center
URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/312
► The influence of respiratory motion on patient anatomy poses a challenge to accurate radiation therapy, especially in lung cancer treatment. Modern radiation therapy planning…
(more)
▼ The influence of respiratory motion on patient anatomy poses a challenge to accurate radiation therapy, especially in lung cancer treatment. Modern radiation therapy planning uses models of tumor respiratory motion to account for target motion in targeting. The tumor motion model can be verified on a per-treatment session basis with four-dimensional cone-beam computed tomography (4D-CBCT), which acquires an image set of the dynamic target throughout the respiratory cycle during the therapy session. 4D-CBCT is undersampled if the scan time is too short. However, short scan time is desirable in clinical practice to reduce patient setup time. This dissertation presents the design and optimization of 4D-CBCT to reduce the impact of undersampling artifacts with short scan times. This work measures the impact of undersampling artifacts on the accuracy of target motion measurement under different sampling conditions and for various object sizes and motions. The results provide a minimum scan time such that the target tracking error is less than a specified tolerance. This work also presents new image reconstruction algorithms for reducing undersampling artifacts in undersampled datasets by taking advantage of the assumption that the relevant motion of interest is contained within a volume-of-interest (VOI). It is shown that the VOI-based reconstruction provides more accurate image intensity than standard reconstruction. The VOI-based reconstruction produced 43% fewer least-squares error inside the VOI and 84% fewer error throughout the image in a study designed to simulate target motion. The VOI-based reconstruction approach can reduce acquisition time and improve image quality in 4D-CBCT.
Advisors/Committee Members: Tinsu Pan, George Starkschall, Peter Balter.
Subjects/Keywords: Medical imaging; lung imaging; radiation therapy; IGRT; image reconstruction; cone-beam CT; 4D imaging; 4D-CBCT; VOI; GSBS; Analytical, Diagnostic and Therapeutic Techniques and Equipment; Medicine and Health Sciences; Numerical Analysis and Scientific Computing; Physics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ahmad, M. (2012). Design and Optimization of Four-dimensional Cone-beam Computed Tomography in Image-guided Radiation Therapy. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/312
Chicago Manual of Style (16th Edition):
Ahmad, Moiz. “Design and Optimization of Four-dimensional Cone-beam Computed Tomography in Image-guided Radiation Therapy.” 2012. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2021.
https://digitalcommons.library.tmc.edu/utgsbs_dissertations/312.
MLA Handbook (7th Edition):
Ahmad, Moiz. “Design and Optimization of Four-dimensional Cone-beam Computed Tomography in Image-guided Radiation Therapy.” 2012. Web. 27 Feb 2021.
Vancouver:
Ahmad M. Design and Optimization of Four-dimensional Cone-beam Computed Tomography in Image-guided Radiation Therapy. [Internet] [Doctoral dissertation]. Texas Medical Center; 2012. [cited 2021 Feb 27].
Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/312.
Council of Science Editors:
Ahmad M. Design and Optimization of Four-dimensional Cone-beam Computed Tomography in Image-guided Radiation Therapy. [Doctoral Dissertation]. Texas Medical Center; 2012. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/312

The Ohio State University
16.
Flanagan, Shawn D.
Neurological Basis of Persistent Functional Deficits after
Traumatic Musculoskeletal Injury.
Degree: PhD, Kinesiology, 2016, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1469031876
► Traumatic musculoskeletal injury is associated with chronic functional deficitsthat may result from changes in brain function and structure. The neurologicalunderpinnings of such maladaptive responses are…
(more)
▼ Traumatic musculoskeletal injury is associated with
chronic functional deficitsthat may result from changes in brain
function and structure. The neurologicalunderpinnings of such
maladaptive responses are unknown and clarification willlikely
require the use of multimodal neuroscientific techniques that
perturb andmeasure brain activity with high temporal and spatial
resolution. The purpose ofthis investigation was to produce a
neurological map of knee function underresting and active
conditions, including the identification of brain circuits
affectedby traumatic musculoskeletal injury. Twenty-three women
(N=23, age 21±3yr,weight 65.8±8.8kg, height 165.2±6.2cm)
volunteered to participate in a series ofmixed methods experiments.
Ten subjects experienced unilateral anteriorcruciate ligament (ACL)
rupture and reconstruction six months to five years priorto the
study (3.1±1.1yr). Thirteen age-, height-, weight-, handedness-,
andfootedness-matched participants served as controls. The
neurological basis ofpersistent functional deficits was examined on
three separate occasions withtranscranial magnetic stimulation,
tests of physical performance, and functionalmagnetic resonance
imaging. Comparisons of corticospinal, functional, andhemodynamic
responses were made between the injured and uninjured leg
ofsubjects with traumatic injury and controls with no history of
lower body injury.At rest, leg injury was associated with a
reduction in the excitability of the motorcortical circuits
governing the injured leg. Injury was also associated with
lowermaximal force production in the injured leg and a reduction
force asymmetrycompared to controls. Altered sensorimotor functions
included impaireddevelopment of fine motor skill and a trend of
proprioceptive loss with increasedreliance on visual inputs.
Imagined use of the injured leg during a task thatchallenged
executive function increased activity in the respective
sensorimotorregions to a lesser extent compared with controls. Most
notably, activity in theright dorsolateral prefrontal cortex
(dlPFC) increased more in injured participatesand the magnitude was
proportional to the extent of injured leg use.In summary, we
observed long-term bilateral impairments in various measures
ofperformance after traumatic musculoskeletal injury. Deficits were
associated withalterations in the corticospinal circuits that
govern the legs. Moreover, we presentevidence to suggest such
changes may partially reflect alterations in salience ormotivation
produced in the prefrontal association cortex.
Pharmacological,electromagnetic, or behavioral therapies that
favorably modulate such activityrepresent attractive candidates for
the improvement of long-term outcomes andrecovery during
rehabilitation.
Advisors/Committee Members: Kraemer, William (Advisor).
Subjects/Keywords: Anatomy and Physiology; Biology; Electromagnetism; Experiments; Health Sciences; Kinesiology; Medical Imaging; Neurobiology; Neurosciences; Neurology; Physical Therapy; Physiology; Psychobiology; Rehabilitation; Scientific Imaging; Sports Medicine; Transcranial Magnetic Stimulation; functional magnetic resonance imaging; musculoskeletal injury; physical performance; neuroplasticity; central nervous system; neurophysiology; neuroscience; anterior cruciate ligament
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MLA ·
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APA (6th Edition):
Flanagan, S. D. (2016). Neurological Basis of Persistent Functional Deficits after
Traumatic Musculoskeletal Injury. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1469031876
Chicago Manual of Style (16th Edition):
Flanagan, Shawn D. “Neurological Basis of Persistent Functional Deficits after
Traumatic Musculoskeletal Injury.” 2016. Doctoral Dissertation, The Ohio State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1469031876.
MLA Handbook (7th Edition):
Flanagan, Shawn D. “Neurological Basis of Persistent Functional Deficits after
Traumatic Musculoskeletal Injury.” 2016. Web. 27 Feb 2021.
Vancouver:
Flanagan SD. Neurological Basis of Persistent Functional Deficits after
Traumatic Musculoskeletal Injury. [Internet] [Doctoral dissertation]. The Ohio State University; 2016. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1469031876.
Council of Science Editors:
Flanagan SD. Neurological Basis of Persistent Functional Deficits after
Traumatic Musculoskeletal Injury. [Doctoral Dissertation]. The Ohio State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1469031876

Cleveland State University
17.
Pogul, Brinda Balchand.
CORTICAL REPRESENTATIONS AND MOTOR PERFORMANCE OF THE DIGITS
IN PATIENTS WITH CARPAL TUNNEL SYNDROME.
Degree: MSin Biomedical Engineering, Washkewicz College of Engineering, 2018, Cleveland State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=csu1529257236449936
► Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy and is characterized by compression of the median nerve. Median nerve injury in CTS patients…
(more)
▼ Carpal tunnel syndrome (CTS) is the most common
peripheral neuropathy and is characterized by compression of the
median nerve. Median nerve injury in CTS patients alters the
afferent-efferent processing circuit within the central nervous
system, affecting digits’ sensory and motor performance. Studies
have reported that the disrupted afferent input in CTS reorganizes
the digit cortical representation in the primary sensory cortex
(S1) of median nerve innervated digits, with the exception of the
thumb. However, the extent of altered digit representation in the
primary motor cortex (M1) due to CTS remains to be determined. It
is important to evaluate S1/M1 reorganization because alterations
at the cortical level due to CTS may undermine digit performance,
including the interdependency and stability of digit forces during
manual tasks. Moreover, by providing augmented tactile information
at the digit pad to compensate for patients diminished sensory
capacity, it may be possible to reverse or rehabilitate impaired
performance.Therefore, the objective of this thesis was to
investigate CTS-induced alterations in digit cortical
representations of the thumb and forefinger and to examine each
individual digits’ motor performance with and without tactile
stimulation. Firstly, CTS-induced alterations in the cortical
representation of the thumb and forefinger were examined in the S1
and M1 cortices using high resolution functional magnetic resonance
imaging (fMRI). Then digit’s interdependency and force stability of
the thumb and forefinger were investigated with and without
vibrotactile stimulation applied to the digit pad. The results from
this study showed that CTS is associated with altered digit
cortical representations with decreased activation strength and
decreased distinctiveness in both S1 and M1 regions. We also
observed that CTS patients demonstrated increased digit
interdependency and force variability compared to controls. Forced
variability, but not interdependency, improved through tactile
stimulation.The results of this thesis helped to identify both
alterations at the cortical level as well as digit motor
performance of the thumb and forefinger in CTS patients as compared
to healthy subjects. It also provided evidence in favor of
vibrotactile therapy for motor rehabilitation. This approach may
aid in the development of new strategies for diagnosis,
rehabilitation, and treatment of this hand disorder.
Advisors/Committee Members: LI, ZONG-MING (Committee Chair).
Subjects/Keywords: Biomedical Engineering; Biomedical Research; Biomechanics; Engineering; Neurobiology; Neurosciences; Neurology; Radiology; Rehabilitation; Science Education; Scientific Imaging; Digit Cortical Representations, fMRI, Digit Motor
Performance, Carpal Tunnel Syndrome
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pogul, B. B. (2018). CORTICAL REPRESENTATIONS AND MOTOR PERFORMANCE OF THE DIGITS
IN PATIENTS WITH CARPAL TUNNEL SYNDROME. (Masters Thesis). Cleveland State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=csu1529257236449936
Chicago Manual of Style (16th Edition):
Pogul, Brinda Balchand. “CORTICAL REPRESENTATIONS AND MOTOR PERFORMANCE OF THE DIGITS
IN PATIENTS WITH CARPAL TUNNEL SYNDROME.” 2018. Masters Thesis, Cleveland State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=csu1529257236449936.
MLA Handbook (7th Edition):
Pogul, Brinda Balchand. “CORTICAL REPRESENTATIONS AND MOTOR PERFORMANCE OF THE DIGITS
IN PATIENTS WITH CARPAL TUNNEL SYNDROME.” 2018. Web. 27 Feb 2021.
Vancouver:
Pogul BB. CORTICAL REPRESENTATIONS AND MOTOR PERFORMANCE OF THE DIGITS
IN PATIENTS WITH CARPAL TUNNEL SYNDROME. [Internet] [Masters thesis]. Cleveland State University; 2018. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1529257236449936.
Council of Science Editors:
Pogul BB. CORTICAL REPRESENTATIONS AND MOTOR PERFORMANCE OF THE DIGITS
IN PATIENTS WITH CARPAL TUNNEL SYNDROME. [Masters Thesis]. Cleveland State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1529257236449936

The Ohio State University
18.
Hwangbo, Ju Won.
Integration of Orbital and Ground Imagery for Automation of
Rover Localization.
Degree: PhD, Geodetic Science and Surveying, 2010, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1276835399
► Rover localization is essential to the exploration of space. The availability of sub-meter resolution satellite imagery, especially High Resolution Imaging Science Experiment (HiRISE) onboard the…
(more)
▼ Rover localization is essential to the exploration of
space. The availability of sub-meter resolution satellite imagery,
especially High Resolution
Imaging Science Experiment (HiRISE)
onboard the Mars Reconnaissance Orbiter (MRO), has opened the
possibility of computing rover locations at higher accuracy by
making use of detailed features seen in the satellite orbital
images. This dissertation describes a new development towards
automation of the rover localization process, using orbital and
ground image networks.A HiRISE orbital image network on Mars is
constructed based on a rigorous sensor model, bundle adjustment of
HiRISE stereo images and absolute positioning using Mars Orbiter
Laser Altimeter (MOLA) data. The unique HiRISE sensor configuration
consists of 14 CCDs fixed to a focal plane. Due to the complexity
of its sensor geometry, two technical issues need to be resolved in
HiRISE stereo processing for precision topographic mapping. These
technical issues are achieving coherence in the exterior
orientation parameters between stereos as well as overlapping CCDs,
and accurate geopositioning of HiRISE data without ground-control
points. In this research, bundle adjustment strategies based on
polynomial function models are applied to improve the
exterior-orientation parameters. Disagreement between HiRISE CCDs
is handled by the bundle adjustment, using inter-CCD tie points.
HiRISE DTM was matched with MOLA DTM and points data to obtain the
absolute position of the stereo model. Performance analysis of this
new experiment will be given. A ground image network is also
constructed using matching of Mars Exploration Rover (MER) stereo
images. Rocks detected from both orbital and ground imagery serve
as tie points for rover localization. From orbital images, rocks
are extracted based on brightness values and the shape of dark
spots. Rocks in ground images are extracted through dense stereo
matching, rock peak and surface point extraction, and rock
modeling. To narrow down a precise rover position, terrain matching
is performed using DTMs generated from orbital and ground imagery.
Finally, distribution pattern matching is implemented for rocks
detected from orbital and ground imagery. The rover position is
adjusted based on a 2-D affine transformation obtained from rock
pattern matching. The proposed method has been tested for the
Spirit rover traverse. Selection of optimal parameter values and
quality control is discussed. Experimental results show that the
orbital/ground rock matching approach has performed successfully
for MER rover localization.
Advisors/Committee Members: Li, Rongxing (Advisor), Saalfeld, Alan (Committee Chair).
Subjects/Keywords: Engineering; Robots; Scientific Imaging; Technology; Photogrammetry; image processing; rover localization
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hwangbo, J. W. (2010). Integration of Orbital and Ground Imagery for Automation of
Rover Localization. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1276835399
Chicago Manual of Style (16th Edition):
Hwangbo, Ju Won. “Integration of Orbital and Ground Imagery for Automation of
Rover Localization.” 2010. Doctoral Dissertation, The Ohio State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1276835399.
MLA Handbook (7th Edition):
Hwangbo, Ju Won. “Integration of Orbital and Ground Imagery for Automation of
Rover Localization.” 2010. Web. 27 Feb 2021.
Vancouver:
Hwangbo JW. Integration of Orbital and Ground Imagery for Automation of
Rover Localization. [Internet] [Doctoral dissertation]. The Ohio State University; 2010. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1276835399.
Council of Science Editors:
Hwangbo JW. Integration of Orbital and Ground Imagery for Automation of
Rover Localization. [Doctoral Dissertation]. The Ohio State University; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1276835399

University of Western Ontario
19.
Kazemifar, Samaneh.
Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease.
Degree: 2016, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/4240
► Alzheimer disease is considered to be a progressive neurodegenerative condition, clinically characterized by cognitive dysfunction and memory impairments. Incorporating imaging biomarkers in the early diagnosis…
(more)
▼ Alzheimer disease is considered to be a progressive neurodegenerative condition, clinically characterized by cognitive dysfunction and memory impairments. Incorporating imaging biomarkers in the early diagnosis and monitoring of disease progression is increasingly important in the evaluation of novel treatments. The purpose of the work in this thesis was to develop and evaluate novel structural and functional biomarkers of disease to improve Alzheimer disease diagnosis and treatment monitoring. Our overarching hypothesis is that magnetic resonance imaging methods that sensitively measure brain structure and functional impairment have the potential to identify people with Alzheimer’s disease prior to the onset of cognitive decline. Since the hippocampus is considered to be one of the first brain structures affected by Alzheimer disease, in our first study a reliable and fully automated approach was developed to quantify medial temporal lobe atrophy using magnetic resonance imaging. This measurement of medial temporal lobe atrophy showed differences (pnovel biomarker of brain activity was developed based on a first-order textural feature of the resting state functional magnetic resonance imagining signal. The mean brain activity metric was shown to be significantly lower (pp18F labeled fluorodeoxyglucose positron emission tomography. In the final study, we examine whether combined measures of gait and cognition could predict medial temporal lobe atrophy over 18 months in a small cohort of people (N=22) with mild cognitive impairment. The results showed that measures of gait impairment can help to predict medial temporal lobe atrophy in people with mild cognitive impairment. The work in this thesis contributes to the growing evidence the specific magnetic resonance imaging measures of brain structure and function can be used to identify and monitor the progression of Alzheimer’s disease. Continued refinement of these methods, and larger longitudinal studies will be needed to establish whether the specific metrics of brain dysfunction developed in this thesis can be of clinical benefit and aid in drug development.
Subjects/Keywords: Alzheimer disease; Mild cognitive impairment; Magnetic resonance imaging; Resting state function magnetic resonance imaging; Gait; Atrophy; Analysis; Analytical, Diagnostic and Therapeutic Techniques and Equipment; Diagnosis; Longitudinal Data Analysis and Time Series; Medical Biophysics; Multivariate Analysis; Neurosciences; Numerical Analysis and Scientific Computing; Theory and Algorithms
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kazemifar, S. (2016). Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/4240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kazemifar, Samaneh. “Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease.” 2016. Thesis, University of Western Ontario. Accessed February 27, 2021.
https://ir.lib.uwo.ca/etd/4240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kazemifar, Samaneh. “Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease.” 2016. Web. 27 Feb 2021.
Vancouver:
Kazemifar S. Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2021 Feb 27].
Available from: https://ir.lib.uwo.ca/etd/4240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kazemifar S. Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/4240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Young, Elizabeth Ann.
Axonal Na/K ATPase: Localization, Loss, and Lessons
Learned.
Degree: PhD, Neurosciences, 2010, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1278699912
► Degeneration of chronically demyelinated axons is the leading causative factor in the progression of symptoms experienced by patients with multiple sclerosis (MS), despite the fact…
(more)
▼ Degeneration of chronically demyelinated axons is the
leading causative factor in the progression of symptoms experienced
by patients with multiple sclerosis (MS), despite the fact that MS
has defied classification as a primary neurodegenerative disease.
While there are many potential causes of neuronal damage
immediately following demyelination, it is within the context of
chronic demyelination that the fundamental and intrinsic mechanisms
of axonal function can, themselves, become detrimental to axonal
integrity. In the wake of demyelination, extensive submembranous
cytoskeletal derangement occurs, allowing the once-nodal
voltage-gated sodium channels (NaV) to diffuse along the denuded
length of the axon. The immediate impact on the axon is two-fold;
first is a spatially unrestricted influx of sodium and an
associated increase in axoplasmic sodium ([Na]i), second is
abrogation of saltatory conduction, which relies on focal sodium
influx. In response to a global increase in [Na]i, typically caused
by an action potential, the sodium/potassium adenosine
triphosphatase (Na/K ATPase), or the sodium pump, hydrolyzes ATP to
power the active transport of three intracellular sodium ions for
two extracellular potassium ions and, thereby, repolarization of
the cell. The cell is driven into an energy debt, causing stress to
mitochondria and, thereby, decreasingATP production. Without
sufficient axonal ATP, the Na/K ATPase cannot transport ions across
the axolemma. With the Na/K ATPases unable to transport additional
sodium across the axolemma, [Na]i increases and the sodium/calcium
exchanger (NCX) is driven to reverse its function and exchange
intracellular sodium for extracellular calcium. An unchecked rise
in axoplasmic calcium can lead to the induction of many deleterious
calcium-dependent degradative pathways and the eventual
degeneration of the demyelinated axon. In these studies, the
“secondary neurodegeneration” of MS is explored; specifically, how
the energetic properties of the chronically demyelinated axon lead
to a series of events, beginning, most notably, with the loss of
the Na/K ATPase, that lead to a run-down of the axolemmal membrane
potential and, eventually, axonal degeneration.
Advisors/Committee Members: Trapp, Bruce (Advisor), Miller, Robert (Committee Chair).
Subjects/Keywords: Anatomy and Physiology; Biology; Biomedical Research; Neurology; Pharmaceuticals; Scientific Imaging; Axonal Degeneration; Neurodegeneration; multiple sclerosis; MRI; MTR; T1; imaging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Young, E. A. (2010). Axonal Na/K ATPase: Localization, Loss, and Lessons
Learned. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1278699912
Chicago Manual of Style (16th Edition):
Young, Elizabeth Ann. “Axonal Na/K ATPase: Localization, Loss, and Lessons
Learned.” 2010. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1278699912.
MLA Handbook (7th Edition):
Young, Elizabeth Ann. “Axonal Na/K ATPase: Localization, Loss, and Lessons
Learned.” 2010. Web. 27 Feb 2021.
Vancouver:
Young EA. Axonal Na/K ATPase: Localization, Loss, and Lessons
Learned. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2010. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1278699912.
Council of Science Editors:
Young EA. Axonal Na/K ATPase: Localization, Loss, and Lessons
Learned. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1278699912
21.
Wang, Fangjing.
Biomedical Imaging of Stem Cells Using Reporter
Genes.
Degree: PhD, Biomedical Engineering, 2010, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1261441999
► Mesenchymal stem cells (MSCs), derived from nearly all adult organs, can differentiate into multiple lineages including osteoblasts, chondrocytes and adipocytes under different local micro-environments…
(more)
▼ Mesenchymal stem cells (MSCs), derived from
nearly all adult organs, can differentiate into multiple lineages
including osteoblasts, chondrocytes and adipocytes under different
local micro-environments for tissue repair. MSCs have also shown to
ameliorate graft versus host disease (GVHD) caused by allogeneic
hematopoietic stem cell transplantation, via suppressing the
activation and proliferation of the alloreactive lymphocytes.
Therefore, MSCs have great potential in bone tissue regeneration
and stem cell-based therapies. However, previous techniques to
track stem cells in vivo are usually associated with frequent
animal sacrifice followed by subsequent histology analysis or
RT-PCR verification. A continuous, non-invasive, real time and
longitudinal
imaging technique is lacking. In
this study, we aimed to establish such a platform technology to
image stem cell biodistribution in a disease model (GVHD) in vivo.
A triple-reporter gene containing luc-mrfp–ttk was incorporated
into hMSCs via lentiviral transduction. The gene of luc was imaged
with BLI and ttk imaged with PET. The proliferation rate of the
transduced stem cells was reduced compared to the wild type cells
although the stem cell differentiation potential was reserved. The
transcriptional changes between transduced and wild-type stem cells
were examined via gene microarrays to identify the key genes
related to proliferation and mesenchymal differentiation to
determine the transduction effect. Stem cells that were loaded into
ceramic cubes and implanted into NOD/SCID mice s.c. were
longitudinally imaged in vivo by BLI for more than 3 months. PET
was also capable of
imaging the implanted stem cells in the ceramic
cubes. Histology studies confirmed the formation of bone from the
transduced hMSCs in vivo. These indicate that the
imaging template
was successfully developed. In an animal model
of GVHD developed in mice, hMSCs were injected intravenously for
the treatment of this disease. It was shown that hMSCs enhanced the
survival of the GVHD mice compared to the untreated mice. BLI
results showed primary entrapment of hMSCs in lung, while only a
small fraction of cells transiently migrated to the intestine.
Cells in the mice were undetectable 7 days after their
transplantation. Although arterial injection led to enhanced cell
distribution into different organs such as intestines, and
prolonged hMSC retention in allogeneic mice, no efficacy was
observed compared with the control group possibly due to the injury
associated with the surgery procedure that allowed arterial
injection. These data suggest that timely cell injection and
repeated injection may be necessary to effectively prevent or
alleviate this disease. In summary, this
imaging
technology plays an important role in tracking stem cells, in
revealing disease development mechanisms, as well as in optimizing
stem cell treatment strategy.
Advisors/Committee Members: Saidel, Gerald (Committee Chair), Lee, Zhenghong (Advisor).
Subjects/Keywords: Biomedical Research; Engineering; Scientific Imaging; Imaging; BLI; PET; GVHD; mesenchymal stem cells; reporter gene; non-invasive; repeated
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wang, F. (2010). Biomedical Imaging of Stem Cells Using Reporter
Genes. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1261441999
Chicago Manual of Style (16th Edition):
Wang, Fangjing. “Biomedical Imaging of Stem Cells Using Reporter
Genes.” 2010. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1261441999.
MLA Handbook (7th Edition):
Wang, Fangjing. “Biomedical Imaging of Stem Cells Using Reporter
Genes.” 2010. Web. 27 Feb 2021.
Vancouver:
Wang F. Biomedical Imaging of Stem Cells Using Reporter
Genes. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2010. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1261441999.
Council of Science Editors:
Wang F. Biomedical Imaging of Stem Cells Using Reporter
Genes. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1261441999

Miami University
22.
Taulbee, Anita R.
Terahertz Time-Domain Spectroscopy and Imaging of Biological
Compounds and Tissues.
Degree: PhD, Chemistry, 2009, Miami University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=miami1249412289
► This dissertation consists of four chapters detailing terahertz time-domain spectroscopy (THz-TDS) and the application thereof to the investigation of biological samples and related analytes.…
(more)
▼ This dissertation consists of four chapters
detailing terahertz time-domain spectroscopy (THz-TDS) and the
application thereof to the investigation of biological samples and
related analytes. Chapter 1 provides a
background of the evolution of THz-TDS from a historical and
physics/engineering perspective followed by an extensive section
from a chemistry perspective dedicated to the interaction of THz
radiation with matter. A variety of measurement techniques are
discussed, culminating in a literature review.
Chapter 2 focuses on the investigation of the 20 essential amino
acids as crystalline solids using THz spectroscopy, in which
absorbance of THz frequencies by crystal lattice phonon propagation
is documented. A study dedicated to qualitative analysis of
L-alanine introduces a novel approach for the spectral assignment
of the observed THz absorbance frequencies to the crystal structure
of the analyte. Chapter 3 presents the study of
five types of excised human breast tissue – normal, benign, lobular
carcinoma, ductal carcinoma in situ and invasive ductal carcinoma –
using THz pulsed
imaging, which consists of successive THz-TDS
measurements over a two-dimensional space. The presentation and
evaluation of the tissue images are supplemented with the
examination of frequency-domain reflectance spectra of selected
tissue areas. The results of the studies presented herein are
followed by detailed guidelines for the maximization of the
efficiency and benefit of continued pursuits in this
field. Chapter 4 investigates the potential of
reflectance-mode THz-TDS as a method for the non-destructive
determination of the gel-point of sol-gel monoliths. Results are
used to compare the gel point properties of sol-gels with and
without a stabilizing dendrimer. The conclusions are found to
support a particular theory concerning the stabilization mechanism
of the dendrimer in the sol-gel process.
Advisors/Committee Members: Pacey, Gilbert (Advisor), Cox, James (Committee Chair).
Subjects/Keywords: Analytical Chemistry; Biomedical Research; Chemistry; Experiments; Molecules; Radiation; Scientific Imaging; Statistics; terahertz; spectroscopy; imaging; cancer; amino acid; L-alanine; statistics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Taulbee, A. R. (2009). Terahertz Time-Domain Spectroscopy and Imaging of Biological
Compounds and Tissues. (Doctoral Dissertation). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1249412289
Chicago Manual of Style (16th Edition):
Taulbee, Anita R. “Terahertz Time-Domain Spectroscopy and Imaging of Biological
Compounds and Tissues.” 2009. Doctoral Dissertation, Miami University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=miami1249412289.
MLA Handbook (7th Edition):
Taulbee, Anita R. “Terahertz Time-Domain Spectroscopy and Imaging of Biological
Compounds and Tissues.” 2009. Web. 27 Feb 2021.
Vancouver:
Taulbee AR. Terahertz Time-Domain Spectroscopy and Imaging of Biological
Compounds and Tissues. [Internet] [Doctoral dissertation]. Miami University; 2009. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1249412289.
Council of Science Editors:
Taulbee AR. Terahertz Time-Domain Spectroscopy and Imaging of Biological
Compounds and Tissues. [Doctoral Dissertation]. Miami University; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1249412289
23.
Fleming, Christine P.
Characterization of Cardiac Tissue Using Optical Coherence
Tomography.
Degree: PhD, Biomedical Engineering, 2010, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1270718628
► Radiofrequency ablation (RFA) therapy is the standard of care for the treatment of cardiac arrhythmias. Current techniques to guide ablation therapy utilize low resolution two…
(more)
▼ Radiofrequency ablation (RFA) therapy is the standard
of care for the treatment of cardiac arrhythmias. Current
techniques to guide ablation therapy utilize low resolution two
dimensional fluoroscopic images and functional measurements from
the RFA catheter, temperature, impedance and electrograms. High
resolution, depth resolved
imaging is needed to characterize early
structural changes in the myocardium due to disease and therapy.
Optical coherence tomography (OCT) is a noninvasive
imaging
modality that provides high resolution, depth resolved
imaging of
tissue microstructure in real time. OCT provides subsurface
imaging
of depths 1-2 mm in cardiac tissue with high spatial resolution
(~10 μm) in three dimensions and high sensitivity in vivo. An
automated algorithm for fiber orientation quantification in the
plane parallel to the wall surface was developed. The algorithm was
applied to volumetric image sets of wild type mouse ventricles, and
normal and infarctions within rabbit ventricles. Using an ex vivo
wedge swine model, we demonstrated that OCT can distinguish
necrotic ablation lesions from untreated tissue and identify
precursors to overtreatment. OCT image features were observed that
clearly distinguish untreated myocardium, ablation lesions,
epicardial fat, and coronary vessels and assess tissue contact with
catheter based
imaging, potential critical structures for real-time
guidance of epicardial RFA therapy. A forward scanning OCT catheter
was prototyped that provides contact, cone scanning with no metal
was used to visualization of real time increase in intensity and
decrease in gradient strength and
imaging ex vivo of the
endocardial surface of the right ventricle submerged in heparinized
blood, where an image of the myocardium was obtained when the
catheter was in direct contact with the tissue, displacing the
blood. Using the forward
imaging probe, we demonstrated the first
use of OCT to image the endocaridum and visualize dynamics due to
RF energy delivery in a living animal. OCT can provide real-time
direct visualization of RFA treatment to confirm energy delivery
and visualize lesion formation, image in the presence of blood,
visualize critical structures and potentially identify
arrhythmogenic substrates. This feedback may increase RFA therapy
procedural success, reduce procedural time, and reduce complication
rates.
Advisors/Committee Members: Rollins, Andrew (Advisor).
Subjects/Keywords: Biomedical Research; Engineering; Optics; Scientific Imaging; optical coherence tomography; biomedical optics; image processing; cardiac imaging; radiofrequency ablation
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fleming, C. P. (2010). Characterization of Cardiac Tissue Using Optical Coherence
Tomography. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1270718628
Chicago Manual of Style (16th Edition):
Fleming, Christine P. “Characterization of Cardiac Tissue Using Optical Coherence
Tomography.” 2010. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1270718628.
MLA Handbook (7th Edition):
Fleming, Christine P. “Characterization of Cardiac Tissue Using Optical Coherence
Tomography.” 2010. Web. 27 Feb 2021.
Vancouver:
Fleming CP. Characterization of Cardiac Tissue Using Optical Coherence
Tomography. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2010. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1270718628.
Council of Science Editors:
Fleming CP. Characterization of Cardiac Tissue Using Optical Coherence
Tomography. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1270718628

University of Akron
24.
Ravi, Anandh.
Efficacy of a Multi-Channel Array Coil for Pediatric Cardiac
Magnetic Resonance Imaging.
Degree: MSin Engineering, Biomedical Engineering, 2008, University of Akron
URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1226615129
► Pediatric MR imaging currently uses adult RF coils which reduces the quality of pediatric images considering the large field of view and low signal to…
(more)
▼ Pediatric MR
imaging currently uses adult RF coils
which reduces the quality of pediatric images considering the large
field of view and low signal to noise ratio (SNR). Thus there is a
growing need for developing and evaluating specialty coils
targeting pediatric patients. The current study focused on the
design, development and evaluation of infant cardiac array RF local
coil for magnetic resonance
imaging of the heart of infant
patients. The design criteria were identified and the coil was
designed taking into account the safety considerations for the
targeted patient population. This study successfully evaluated the
performance of the infant cardiac array RF coil based on two most
significant MR
imaging parameters, SNR and
imaging resolution, on a
1.5T commercial MR scanner. The increase in SNR and improvement in
the resolution of images using the infant cardiac array over an
existing commercially available adult coil was establishedusing
different kinds of phantom (7L, 2L, orange and lime) studies. The
results revealed that there was an increase of 140% in SNR using
infant cardiac array compared to the commercially available adult
coil and the high resolution (<200 microns) images obtained
confirmed the efficacy of the infant cardiac array coil. Thus, the
infant cardiac array RF coil provides enhanced performance and high
quality MR images for infant clinical applications compared to the
commercial adult coils.
Advisors/Committee Members: Reddy, Narender P. (Advisor), Sheffer, Daniel B. (Advisor).
Subjects/Keywords: Biomedical Research; Engineering; Health Care; Radiology; Scientific Imaging; RF coil; MRI; Cardiac; Infant cardiac imaging; Radiology; Magnetic Resonance Imaging; Infant cadiac array
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ravi, A. (2008). Efficacy of a Multi-Channel Array Coil for Pediatric Cardiac
Magnetic Resonance Imaging. (Masters Thesis). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1226615129
Chicago Manual of Style (16th Edition):
Ravi, Anandh. “Efficacy of a Multi-Channel Array Coil for Pediatric Cardiac
Magnetic Resonance Imaging.” 2008. Masters Thesis, University of Akron. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=akron1226615129.
MLA Handbook (7th Edition):
Ravi, Anandh. “Efficacy of a Multi-Channel Array Coil for Pediatric Cardiac
Magnetic Resonance Imaging.” 2008. Web. 27 Feb 2021.
Vancouver:
Ravi A. Efficacy of a Multi-Channel Array Coil for Pediatric Cardiac
Magnetic Resonance Imaging. [Internet] [Masters thesis]. University of Akron; 2008. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1226615129.
Council of Science Editors:
Ravi A. Efficacy of a Multi-Channel Array Coil for Pediatric Cardiac
Magnetic Resonance Imaging. [Masters Thesis]. University of Akron; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1226615129

University of Akron
25.
Silva Mojica, Ernesto.
Polymer-silica Hybrids for Separation of CO2 and Catalysis
of Organic Reactions.
Degree: PhD, Polymer Science, 2014, University of Akron
URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1398439043
► Porous materials comprising polymeric and inorganic segments have attracted interest from the scientific community due to their unique properties and functionalities. The physical and chemical…
(more)
▼ Porous materials comprising polymeric and inorganic
segments have attracted interest from the
scientific community due
to their unique properties and functionalities. The physical and
chemical characteristics of these materials can be effectively
exploited for adsorption applications. This dissertation covers the
experimental techniques for fabrication of poly(vinyl alcohol)
(PVA) and silica (SiO2) porous supports, and their
functionalization with polyamines for developing adsorbents with
potential applications in separation of CO2 and catalysis of
organic reactions. The supports were synthesized by processes
involving (i) covalent cross-linking of PVA, (ii) hydrolysis and
poly-condensation of silica precursors (i,e,. sol-gel synthesis),
and formation of porous structures via (iii) direct templating and
(iv) phase inversion techniques. Their physical structure was
controlled by the proper combination of the preparation procedures,
which resulted in micro-structured porous materials in the form of
micro-particles, membranes, and pellets. Their adsorption
characteristics were tailored by functionalization with
polyethyleneimine (PEI), and their physicochemical properties were
characterized by vibrational spectroscopy (FTIR, UV-vis),
microscopy (SEM), calorimetry (TGA, DSC), and adsorption techniques
(BET, step-switch adsorption). Spectroscopic investigations of the
interfacial cross-linking reactions of PEI and PVA with
glutaraldehyde (GA) revealed that PEI catalyzes the cross-linking
reactions of PVA in absence of external acid catalysts. In-situ IR
spectroscopy coupled with a focal plane array (FPA) image detector
allowed the characterization of a gradient interface on a PEI/PVA
composite membrane and the investigation of the cross-linking
reactions as a function of time and position. The results served as
a basis to postulate possible intermediates, and propose the
reaction mechanisms. The formulation of amine-functionalized CO2
capture sorbents was based on the spectroscopic investigation of
the interactions of CO2 with amine molecules under simulated CO2
capture conditions. Industrial CO2 capture processes involve
fluidization and require degradation-resistant sorbents in the form
of pellets. Agglomeration of silica-based CO2 capture sorbents
involved the formulation of a polymer binder solution and the
design of a scalable pelletization process. The characterization of
these pellets revealed the formation of a CO2-permeable
polymer-silica network, which is resistant to attrition, and
exhibits similar CO2 capture and degradation performance as the
non-pelletized sorbents. The performance of these sorbents and
pellets was tested in lab-scale and bench-scale adsorption units,
using in-house fabricated fixed-bed and fluidized-bed reactors. A
compartmental modeling technique was used to simulate the CO2
adsorption process and to elucidate the kinetic and thermodynamic
parameters that impact the commercial viability of emerging CO2
capture technologies.The fundamental concepts and experimental
techniques developed for…
Advisors/Committee Members: Chuang, Steven (Advisor).
Subjects/Keywords: Chemical Engineering; Chemistry; Climate Change; Energy; Engineering; Environmental Engineering; Experiments; Fluid Dynamics; Materials Science; Molecules; Nanotechnology; Organic Chemistry; Polymer Chemistry; Polymers; Scientific Imaging; Technology; Adsorption, CO2, capture, polymer, silica, hybrids,
cross-linking, porous, catalysis, compartmental modeling, enzyme
immobilization, phase inversion, pellet, pelletization, separation,
PVA, PEI, amine, sorbent, membrane, IR, infrared, imaging, SBA-15,
FPA
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Silva Mojica, E. (2014). Polymer-silica Hybrids for Separation of CO2 and Catalysis
of Organic Reactions. (Doctoral Dissertation). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1398439043
Chicago Manual of Style (16th Edition):
Silva Mojica, Ernesto. “Polymer-silica Hybrids for Separation of CO2 and Catalysis
of Organic Reactions.” 2014. Doctoral Dissertation, University of Akron. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=akron1398439043.
MLA Handbook (7th Edition):
Silva Mojica, Ernesto. “Polymer-silica Hybrids for Separation of CO2 and Catalysis
of Organic Reactions.” 2014. Web. 27 Feb 2021.
Vancouver:
Silva Mojica E. Polymer-silica Hybrids for Separation of CO2 and Catalysis
of Organic Reactions. [Internet] [Doctoral dissertation]. University of Akron; 2014. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1398439043.
Council of Science Editors:
Silva Mojica E. Polymer-silica Hybrids for Separation of CO2 and Catalysis
of Organic Reactions. [Doctoral Dissertation]. University of Akron; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1398439043

Tampere University
26.
Takala, Mika.
Asteroid Tomography by Utilizing Nanosatellites
.
Degree: 2020, Tampere University
URL: https://trepo.tuni.fi/handle/10024/122788
► Viimeisen kymmenen vuoden aikana pienten ns. nanosatelliittien hyödyntäminen matalalla Maan kiertoradalla on kasvattanut suosiotaan CubeSat-standardin ansiosta. Nämä nanosatelliitit ovat olleet tärkeä osa ns. uutta avaruusteollisuutta,…
(more)
▼ Viimeisen kymmenen vuoden aikana pienten ns. nanosatelliittien hyödyntäminen matalalla Maan kiertoradalla on kasvattanut suosiotaan CubeSat-standardin ansiosta. Nämä nanosatelliitit ovat olleet tärkeä osa ns. uutta avaruusteollisuutta, jossa toinen toistaan suuremmat tavoitteet on mahdollista saavuttaa halvempaa tekniikkaa hyödyntäen. Nanosatelliitteja on käytetty toistaiseksi pääasiassa tutkimus- ja teknologiankehitystarkoituksiin, ja varsinaiset tieteelliset avaruusmissiot on tehty suurempia avaruuslaitteita käyttäen. Yksi tällaisista missioista oli Euroopan avaruusjärjestö ESA:n Rosetta-missio, joka kohtasi komeetta 67P/Churyumov-Gerasimenkon elokuuussa 2014. Lennon yhtenä peruselementtinä oli kokeilla radiotomografiakoetta, jossa komeetan sisustan rakenne olisi kartoitettu tutkasignaaleilla. Tämä väitöskirja tutkii nanosatelliittien käyttöä pienten Maan lähiasteroidien sisustan kartoitukseen. Tätä ei ole yritetty aikaisemmin. Väitöskirjatutkimuksen aikana ESA valitsi nanosatelliitteja Didymos-asteroidille lentävälle Hera-missiolleen. Yksi valituista nanosatelliiteista sisältää radiotomografiainstrumentin, joka pohjautuu aikaisemmassa Rosetta-missiossa ja sen Philae-laskeutujassa käytettyyn tekniikkaan.
Tämä väitöstutkimus laajentaa Tampereen yliopiston inversio-ongelmien tutkimusryhmän aikaisempaa työtä. Tutkimuksessa on simuloitu radioaaltojen etenemistä asteroidin sisällä elementtimenetelmällä, sekä koko vastaanotetun aaltodatan käyttämistä huippuluokan matemaattisilla inversiomenetelmillä siten, että asteroidin sisä-rakenne saadaan kuvannettua. Painopiste työssä on mittausmenetelmän ja kohinan vaikutuksessa kuvannustulokseen sekä mallinnuksen parantamiseen siten, että elementtimenetelmää voidaan käyttää, vaikka mittausta suorittavat avaruusalukset olisivat simulaatiossa käytetyn elementtiverkon ulkopuolella. Tärkeä osa työtä on myös viimeisimpien grafiikkaprosessoreiden (GPU) hyödyntäminen, koska niiden avulla simulaatioiden suoritusaikaa pystytään nopeuttamaan sekä lokaaleilla työasemilla että laskentaklustereissa.
Nanosatelliitin käyttämisestä tässä tarkoituksessa tehtiin Deep Interior Scanning CubeSat (DISCUS) -niminen soveltuvuustutkimus yhdessä projektikumppaneiden kanssa. DISCUS-konseptin tavoitteena oli lennättää nanosatelliitti Maan lähiasteroidille ja tehdä tarvittavat mittaukset, tallentaa data ja lähettää data Maahan. Tutkimus sisältää analyysin tällä hetkellä saatavilla olevista nanosatelliitien komponenteista, niiden realistisista suoritusarvoista, lennon parametrien analyysin sekä mahdolliset kohdeasteroidit. DISCUS-konseptia laajennettiin myöhemmin avaruusmissioksi nimeltä Asteroid In-situ Interior Investigation - 3way (Ai3), joka oli ehdolla ESA:n F-tyypin missiohaussa kesällä 2018. Vaikka Ai3:a ei valittu, se oli yksi kuudesta ehdotuksesta haun toisella kierroksella. Yleinen kiinnostus Maan lähiasteroidien tutkimukseen osoittaa, että ne ovat tärkeitä tieteen, maapallon puolustuksen sekä myös kaupallisten toimijoiden näkökulmista, mikä motivoi asteroidien kuvantamisen tekniikan…
Subjects/Keywords: Finite Element Time Domain
;
GPU computing
;
Scientific computing
;
Computed tomography
;
Tomography
;
Radar
;
Inverse problems
;
Inverse imaging
;
Asteroids
;
Space
;
Cubesat
;
Nanosatellite
;
Deep Interior Scanning CubeSat
;
DISCUS
;
Planetary Missions
;
Finite element method
;
Feasibility study
;
European Space Agency
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Takala, M. (2020). Asteroid Tomography by Utilizing Nanosatellites
. (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/122788
Chicago Manual of Style (16th Edition):
Takala, Mika. “Asteroid Tomography by Utilizing Nanosatellites
.” 2020. Doctoral Dissertation, Tampere University. Accessed February 27, 2021.
https://trepo.tuni.fi/handle/10024/122788.
MLA Handbook (7th Edition):
Takala, Mika. “Asteroid Tomography by Utilizing Nanosatellites
.” 2020. Web. 27 Feb 2021.
Vancouver:
Takala M. Asteroid Tomography by Utilizing Nanosatellites
. [Internet] [Doctoral dissertation]. Tampere University; 2020. [cited 2021 Feb 27].
Available from: https://trepo.tuni.fi/handle/10024/122788.
Council of Science Editors:
Takala M. Asteroid Tomography by Utilizing Nanosatellites
. [Doctoral Dissertation]. Tampere University; 2020. Available from: https://trepo.tuni.fi/handle/10024/122788

Wright State University
27.
Schrider, Christina Da-Wann.
Histogram-based template matching object detection in images
with varying brightness and contrast.
Degree: MSEgr, Biomedical Engineering, 2008, Wright State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=wright1224044521
► Our challenge was to develop a semi-automatic target detection algorithm to aid human operators in locating potential targets within images. In contrast to currently available…
(more)
▼ Our challenge was to develop a semi-automatic target
detection algorithm to aid human operators in locating potential
targets within images. In contrast to currently available methods,
our approach is relatively insensitive to image brightness, image
contrast and object orientation. Working on overlapping image
blocks, we used a sliding difference method of histogram matching.
Incrementally sliding the histograms of the known object template
and the image region of interest (ROI) together, the sum of
absolute histogram differences was calculated. The minimum of the
resultant array was stored in the corresponding spatial position of
a response surface matrix. Local minima of the response surface
suggest possible target locations. Because the template contrast
will rarely perfectly match the contrast of the actual image
contrast, which can be compromised by illumination conditions,
background features, cloud cover, etc., we perform a random
contrast manipulation, which we term ‘wobble’, on the template
histogram. Our results have shown improved object detection with
the combination of the sliding histogram difference and
wobble.
Advisors/Committee Members: Skipper, Julie (Advisor).
Subjects/Keywords: Biomedical Research; Engineering; Scientific Imaging; object detection; target detection; computer-aided diagnosis; template matching; image contrast
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schrider, C. D. (2008). Histogram-based template matching object detection in images
with varying brightness and contrast. (Masters Thesis). Wright State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=wright1224044521
Chicago Manual of Style (16th Edition):
Schrider, Christina Da-Wann. “Histogram-based template matching object detection in images
with varying brightness and contrast.” 2008. Masters Thesis, Wright State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=wright1224044521.
MLA Handbook (7th Edition):
Schrider, Christina Da-Wann. “Histogram-based template matching object detection in images
with varying brightness and contrast.” 2008. Web. 27 Feb 2021.
Vancouver:
Schrider CD. Histogram-based template matching object detection in images
with varying brightness and contrast. [Internet] [Masters thesis]. Wright State University; 2008. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1224044521.
Council of Science Editors:
Schrider CD. Histogram-based template matching object detection in images
with varying brightness and contrast. [Masters Thesis]. Wright State University; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1224044521

The Ohio State University
28.
Vogt, Keith M.
Optimization of physiologic noise correction in functional
magnetic resonance imaging.
Degree: PhD, Biomedical Engineering, 2009, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1243544877
► Though in widespread clinical and research use as a tool to evaluate brain function, functional magnetic resonance imaging (FMRI) data is severely contaminated by…
(more)
▼ Though in widespread clinical and research
use as a tool to evaluate brain function, functional magnetic
resonance
imaging (FMRI) data is severely contaminated by noise,
due in large part to physiologic noise caused by respiratory and
cardiac variations over time. This dissertation attempts to better
characterize several physiologic noise correction techniques
applied to pain FMRI data. Three studies are described that
collectively work toward determining an optimal physiologic noise
correction algorithm to be used in future pain FMRI studies.
First, a novel algorithm, RetroSLICE, is
described that uses linear regression to correct acquired images
for signal intensity fluctuations correlated to measured
respiratory, cardiac, and capnometry variations. The impact of this
technique was assessed for a 1.5 T pain FMRI experiment. Each
physiologic noise regressor used as a part of the RetroSLICE
algorithm independently resulted in a decrease in timecourse
variance and an improvement in model fit. Combined correction for
the instantaneous effects of respiratory and cardiac variations
caused a 5.4% decrease in signal variance and increased model fit
(mean R
2a) by 65%.
The addition of ETCO
2 correction as part of
the general linear model led to 39% further improvement in model
fit. Each of these corrections also caused changes in the group
activation map. Next, an optimal transfer
function between ETCO
2 level and BOLD signal
changes was empirically determined using FMRI data in which paced
breathing forced a 35% decrease in ETCO
2.
ETCO
2 data convolved with this optimized
response function was compared to another measure, the respiratory
volume over time (RVT) convolved with an optimized respiration
response function. When regressed against FMRI data collected
during a breathing modulation task, ETCO
2
was more strongly and diffusely correlated to the data than RVT.
Conversely, when the same comparative analysis was performed on
pain FMRI data, RVT was more strongly correlated than
ETCO
2. In both cases, allowing ± 2 s
flexibility in the response function peak times did not change the
relative correlation to the MR data of the
ETCO
2 compared to the RVT timecourses.
Finally, the well-known physiologic noise
correction algorithm, RETROICOR, was implemented on pain FMRI data
collected at 1.5 and 3.0 T. Respiratory and cardiac correction with
Fourier series phase fitting caused an 8.2% decrease in signal
variance and a 227% increase in model fit at 1.5 T, indicating
performance superior to RetroSLICE. At 3.0 T, significantly greater
improvements were seen: a 10.4% decrease in signal noise and 240%
increase in mean R2a. ETCO
2 correction
applied with the optimized response function previously determined
caused insignificant changes in noise reduction and model fit.
Further exploration of the properties of the RETROICOR algorithm
showed no difference in impact when applied with physiologic input
data…
Advisors/Committee Members: Schmalbrock, Petra (Advisor), Small, Robert (Committee Chair).
Subjects/Keywords: Engineering; Radiology; Scientific Imaging; functional MRI; brain; pain; physiologic noise correction; RETROICOR; RetroSLICE; ETCO2
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vogt, K. M. (2009). Optimization of physiologic noise correction in functional
magnetic resonance imaging. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1243544877
Chicago Manual of Style (16th Edition):
Vogt, Keith M. “Optimization of physiologic noise correction in functional
magnetic resonance imaging.” 2009. Doctoral Dissertation, The Ohio State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1243544877.
MLA Handbook (7th Edition):
Vogt, Keith M. “Optimization of physiologic noise correction in functional
magnetic resonance imaging.” 2009. Web. 27 Feb 2021.
Vancouver:
Vogt KM. Optimization of physiologic noise correction in functional
magnetic resonance imaging. [Internet] [Doctoral dissertation]. The Ohio State University; 2009. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1243544877.
Council of Science Editors:
Vogt KM. Optimization of physiologic noise correction in functional
magnetic resonance imaging. [Doctoral Dissertation]. The Ohio State University; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1243544877

University of Toledo Health Science Campus
29.
Zahedi, Shadi.
Are Mitochondria a Potential Target for Anti-Cancer Therapy
in Carcinoid Tumors?.
Degree: MSBS, College of Medicine, 2010, University of Toledo Health Science Campus
URL: http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079
► Gastrointestinal (GI) carcinoids are slow growing malignancies of neuroendocrine phenotype that can behave aggressively. To date, there are no effective therapies for metastatic carcinoid cancer.…
(more)
▼ Gastrointestinal (GI) carcinoids are slow growing
malignancies of neuroendocrine phenotype that can behave
aggressively. To date, there are no effective therapies for
metastatic carcinoid cancer. Previous work by our lab and others
has shown that carcinoids express variety of voltage-operated
(VOCCs) and non-voltage-operated Ca2+ channels to allow Ca2+ to
enter the cell. Although, the role of Ca2+ entry in these tumors is
not well understood, previous work by our group and others has
shown that mitochondria are important regulators of
voltage-operated and non-voltage-operated Ca2+ entry. In addition,
cancer cells typically exhibit mitochondrial dysfunction and poor
anti-oxidant status. These observations and the central role that
mitochondria play in metabolism, Ca2+ homeostasis and cell death
pathways make mitochondria an appealing potential target for
anti-cancer treatment in carcinoid tumors. We used an spectrum of
human cancer cell lines and a variety of microfluorescence methods
including wide-field, confocal, and total internal reflection
(TIRF) microscopy to assess Ca2+ signaling and mitochondrial
function in combination with pharmacological interventions to assay
whether mitochondria are a potential target for anti-cancer
therapy. To this end, we tested the effectiveness of an oxidant
therapy approach in carcinoid cells.
Advisors/Committee Members: Giovannucci, David (Committee Chair).
Subjects/Keywords: Biomedical Research; Molecular Biology; Scientific Imaging; carcinoid tumors; mitochondrial; calcium signaling; TIRF microscopy; oxidant therapy; vitamin K3; vitamin C
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APA (6th Edition):
Zahedi, S. (2010). Are Mitochondria a Potential Target for Anti-Cancer Therapy
in Carcinoid Tumors?. (Masters Thesis). University of Toledo Health Science Campus. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079
Chicago Manual of Style (16th Edition):
Zahedi, Shadi. “Are Mitochondria a Potential Target for Anti-Cancer Therapy
in Carcinoid Tumors?.” 2010. Masters Thesis, University of Toledo Health Science Campus. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079.
MLA Handbook (7th Edition):
Zahedi, Shadi. “Are Mitochondria a Potential Target for Anti-Cancer Therapy
in Carcinoid Tumors?.” 2010. Web. 27 Feb 2021.
Vancouver:
Zahedi S. Are Mitochondria a Potential Target for Anti-Cancer Therapy
in Carcinoid Tumors?. [Internet] [Masters thesis]. University of Toledo Health Science Campus; 2010. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079.
Council of Science Editors:
Zahedi S. Are Mitochondria a Potential Target for Anti-Cancer Therapy
in Carcinoid Tumors?. [Masters Thesis]. University of Toledo Health Science Campus; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079
30.
Mamolen, Megan Christine.
DROSOPHILA MELANOGASTER DIS3 IS A DYNAMIC ENDO- AND 3’ to 5’
EXORIBONUCLEASE.
Degree: PhD, Molecular Biology and Microbiology, 2010, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1278525341
► Dis3 is an evolutionarily conserved and essential enzyme with functions in mitosis, and RNA processing and turnover. In this work, we employed both in vitro…
(more)
▼ Dis3 is an evolutionarily conserved and essential
enzyme with functions in mitosis, and RNA processing and turnover.
In this work, we employed both in vitro and in vivo techniques to
examine the biochemical and cell biological characteristics of a
metazoan Dis3 homolog. Here, for the first time, we show that
Drosophila melanogaster Dis3 (dDis3) has in vitro exo- and
endoribonuclease activities. Our results suggest that both
activities employ metal-ion catalysis. Further, neither activity is
substrate-specific in vitro. Interestingly, even though the
exoribonuclease active site resides in the C-terminus, both
activities require the presence of N-terminal Dis3 domains. We show
that N-terminal domains mediate additional Drosophila Dis3
functions. For example, the Drosophila Dis3 N-terminus affects
nuclear localization. The dDis3 N-terminus also contains a
mitochondrial targeting sequence. Finally, N-terminal domains are
responsible for interactions with exosome proteins and the nuclear
import factor Importin-α3. This study demonstrates that Drosophila
melanogaster Dis3 is a complex enzyme with multiple ribonuclease
activities, localization patterns, and protein-protein
interactions.
Advisors/Committee Members: Andrulis, Erik (Advisor), Karn, Jonathan (Committee Chair).
Subjects/Keywords: Biochemistry; Biology; Cellular Biology; Experiments; Molecular Biology; Scientific Imaging; Dis3; exosome; endoribonuclease; exoribonuclease; mitochondria; RNA turnover
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mamolen, M. C. (2010). DROSOPHILA MELANOGASTER DIS3 IS A DYNAMIC ENDO- AND 3’ to 5’
EXORIBONUCLEASE. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1278525341
Chicago Manual of Style (16th Edition):
Mamolen, Megan Christine. “DROSOPHILA MELANOGASTER DIS3 IS A DYNAMIC ENDO- AND 3’ to 5’
EXORIBONUCLEASE.” 2010. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1278525341.
MLA Handbook (7th Edition):
Mamolen, Megan Christine. “DROSOPHILA MELANOGASTER DIS3 IS A DYNAMIC ENDO- AND 3’ to 5’
EXORIBONUCLEASE.” 2010. Web. 27 Feb 2021.
Vancouver:
Mamolen MC. DROSOPHILA MELANOGASTER DIS3 IS A DYNAMIC ENDO- AND 3’ to 5’
EXORIBONUCLEASE. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2010. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1278525341.
Council of Science Editors:
Mamolen MC. DROSOPHILA MELANOGASTER DIS3 IS A DYNAMIC ENDO- AND 3’ to 5’
EXORIBONUCLEASE. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1278525341
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