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Leiden University

1. Mezzadra, R. Genetic manipulation and genetic-based dissection of tumor-specific immunity.

Degree: 2019, Leiden University

URL: http://hdl.handle.net/1887/68811 

In this thesis I have firstly applied gene transfer technologies to the redirection of T cell specificity, by trying to overcome limitations related to non-viral gene transfer systems. In the second part of my PhD work, I focused on genetic screens, which, I applied to understanding molecular mechanisms of escape from T cell attack and to reveal mechanisms of PD-L1 regulation. The work presented in this thesis may on the one hand facilitate the clinical application of non-viral-based gene transfer systems in T cells. On the other hand, the more fundamental discoveries related to IFN-γ-mediated tumor cell killing and PD-L1 regulation may help to further understand resistance toward immunotherapies and how to overcome them. Advisors/Committee Members: Supervisor: Schumacher A.N.M. Co-Supervisor: Peeper D.S..

Subjects/Keywords: PD-L1; T cells; genetic screens; transposon-mediated gene-transfer; SLFN11; IFN-gamma; TCR; PD-L1; T cells; genetic screens; transposon-mediated gene-transfer; SLFN11; IFN-gamma; TCR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mezzadra, R. (2019). Genetic manipulation and genetic-based dissection of tumor-specific immunity. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/68811

Chicago Manual of Style (16th Edition):

Mezzadra, R. “Genetic manipulation and genetic-based dissection of tumor-specific immunity.” 2019. Doctoral Dissertation, Leiden University. Accessed January 19, 2021. http://hdl.handle.net/1887/68811.

MLA Handbook (7th Edition):

Mezzadra, R. “Genetic manipulation and genetic-based dissection of tumor-specific immunity.” 2019. Web. 19 Jan 2021.

Vancouver:

Mezzadra R. Genetic manipulation and genetic-based dissection of tumor-specific immunity. [Internet] [Doctoral dissertation]. Leiden University; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1887/68811.

Council of Science Editors:

Mezzadra R. Genetic manipulation and genetic-based dissection of tumor-specific immunity. [Doctoral Dissertation]. Leiden University; 2019. Available from: http://hdl.handle.net/1887/68811

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