subject:(SIRS)

1. Spanaki, Anna-Maria. Διαχρονικές μεταβολές βιοενέργειας, μεταβολισμού και ανοσολογικής απόκρισης στην οξεία φάση της σοβαρής σήψης.

Degree: 2018, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/44242

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Background: Cell stress induced by severe sepsis (SS) or systemic inflammatory response syndrome (SIRS) presents with acute inflammatory, hormonal, immune and metabolic derangements. Their relation… (more)

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Background: Cell stress induced by severe sepsis (SS) or systemic inflammatory response syndrome (SIRS) presents with acute inflammatory, hormonal, immune and metabolic derangements. Their relation with mitochondrial dysfunction has not been adequately studied.Objectives: The purpose of the study was to evaluate the longitudinal changes of inflammatory-hormonal response, innate-immunity, bioenergetics and metabolism in critically ill patients, adults and children with severe sepsis and to compare them with patients groups with SIRS and healthy groups (H), adults and children.Materials / Methods: We studied 68 children (SS / 18, SIRS / 23, H / 27) and 79 adults (SS / 23, SIRS / 23, H / 33) on 1, 3 and 5 day of hospitalization. Body Mass Index (BMI) z-scores and disease severity scores (PeLOD, APACHE, TISS, SOFA) were calculated. Cardiac contractility (EF, SF), troponin (Tn) and lactate were measured, as well as energy consumption (EE) with Gas Module E-COVX, ATP in white blood cells with luciferase luminescent assay, glutamine and NO2 / NO3 levels with high-pressure liquid chromatography (HPLC), lipid peroxidation products (TBARS) by colorimetric assay, resistin, serum antiponectin and extracellular Heat Shock Proteins (HSP) HSP90α, serum HSP72, adiponectin and resistin by ELISA.Intracellular Heat Shock Proteins (HSP72, HSP90α) expressions by flow cytometry.Results: Longitudinal both in adults (ICU) and children (PICU), resistin, dexponcepin, extracellular HPS72 and 90a values showed a sustained pattern of stimulation throughout the acute 5-day phase. In this period, VO2, VCO2, EE showed a hypometabolic pattern similar in children and adults.The increased expression of NO3, NO2, TBARS and adiponectin in sepsis showed a diffuse pattern relating to their age-related expression per age group. Mitochondrial bioenergy was longitudinal reduced in adults and children who did not survive compared to survivors, and was accompanied by significantly reduced metabolism and hypometabolic patterns on days 3 and 5 (p <0.05). Surviving patients had a significant variation in baseline BVR, lactate, EU, VO2, VCO2 and metabolic profile compared to patients who died, who showed inability to recover hypometabolism or antioxidant status on day 5.Conclusion: SS is characterized from longitudinally stronger intracellular repression of ATP, HPS72, HSP90α, metabolism (EE, albumin, glutamine) and extracellular induction of inflammatory hormones (resistin) and innate immunity proteins signaling acute stress danger (HSP72) compared to SIRS. A pattern of early longitudinal induction of metabolic-hormones and eHSP72/HSP90α, repression of bioenergetics and innate immunity, hypo-metabolism, and amino-acid kinetics changes discriminate sepsis from SIRS; malnutrition, hypometabolism, and persistently increased resistin and adiponectin are associated with poor outcome.KEY WORDS: sepsis, SIRS, bioenergy, HSP, resistin, metabolism, calorimetry; amino acids; nitric oxide; heat shock proteins; ATP; resistin; adiponectin; sepsis; trauma

Εισαγωγή: Το…

Subjects/Keywords: Σήψη; SIRS; Βιοενέργεια; Sepsis; SIRS; Bioenergy

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APA (6^th Edition):

Spanaki, A. (2018). Διαχρονικές μεταβολές βιοενέργειας, μεταβολισμού και ανοσολογικής απόκρισης στην οξεία φάση της σοβαρής σήψης. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/44242

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Spanaki, Anna-Maria. “Διαχρονικές μεταβολές βιοενέργειας, μεταβολισμού και ανοσολογικής απόκρισης στην οξεία φάση της σοβαρής σήψης.” 2018. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed January 22, 2021. http://hdl.handle.net/10442/hedi/44242.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Spanaki, Anna-Maria. “Διαχρονικές μεταβολές βιοενέργειας, μεταβολισμού και ανοσολογικής απόκρισης στην οξεία φάση της σοβαρής σήψης.” 2018. Web. 22 Jan 2021.

Vancouver:

Spanaki A. Διαχρονικές μεταβολές βιοενέργειας, μεταβολισμού και ανοσολογικής απόκρισης στην οξεία φάση της σοβαρής σήψης. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10442/hedi/44242.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spanaki A. Διαχρονικές μεταβολές βιοενέργειας, μεταβολισμού και ανοσολογικής απόκρισης στην οξεία φάση της σοβαρής σήψης. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2018. Available from: http://hdl.handle.net/10442/hedi/44242

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

2. Ranta, Noora. The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study .

Degree: 2016, Tampere University

URL: https://trepo.tuni.fi/handle/10024/98637

► Infektiotaudit ovat tavallinen ongelma päivystysklinikalla. Erityisesti sepsiksen diagnosointi on hankalaa, sillä taudille ei tällä hetkellä ole olemassa sopivaa biomarkkeria. Sepsis on melko yleinen, nopeasti etenevä… (more)

▼ Infektiotaudit ovat tavallinen ongelma päivystysklinikalla. Erityisesti sepsiksen diagnosointi on hankalaa, sillä taudille ei tällä hetkellä ole olemassa sopivaa biomarkkeria. Sepsis on melko yleinen, nopeasti etenevä systeeminen infektio, johon liittyy merkittävän suuri kuolleisuus. Jo parissa päivässä oireiden alkamisesta kehittyvään vakavaan sepsikseen menehtyy noin 70 % potilaista. Tämän vuoksi varhaisen vaiheen diagnostiikka ja nopea, tehokkaan mikrobilääkehoidon aloitus ovat elintärkeitä sepsispotilaille. Biomarkkerin puuttumisen vuoksi hoidon aloitus viivästyy ja potilaan ennuste heikkenee. Aiemmissa tutkimuksissa on havaittu elimistössä laaja-alaisesti esiintyvän proproteiini konvertaasi furiinin yhteys monenlaisiin tulehdustiloihin. Furiini on proteaasientsyymi, joka säätelee muun muassa T auttaja 1 -solujen aktiivisuutta sekä TLR7 reseptorien määrää. Lisäksi lipopolysakkaridi (LPS) lisää sen ilmentymistä makrofageissa. Tutkimuksen tavoitteena on selvittää voitaisiinko päivystyksessä potilaiden plasmanäytteistä mitattuja furiinipitoisuuksia käyttää hyväksi infektion varhaisen vaiheen diagnostiikassa, vakavuuden arvioinnissa, kuolleisuuden ennustamisessa ja/tai oikeanlaisen antibioottihoidon valitsemisessa. Potilasaineisto kerättiin Satakunnan keskussairaalasta vuosina 2004 ja 2005. Se koostuu täysi-ikäisistä, päivystyspoliklinikalle saapuneista infektioepäilypotilaista. Verinäytteet kerättiin päivystyksessä ja muu data haastattelusta ja sairaskertomuksista. Plasman furiinipitoisuus määritettiin kaupallisella ELISA-menetelmällä (Human Furin Enzyme Linked Immunosorbent Assay, Sigma-Aldrich®) ja tulokset jaettiin korkean ja matalan pitoisuuden ryhmiin. Myös potilaat jaoteltiin infektiotyypin perusteella viiteen diagnostiseen ryhmään. Tilastolliset analyysit suoritettiin SPSS-ohjelmalla (IBM, versio 22). Tilastollisesti merkitsevää yhteyttä ei havaittu verrattaessa sepsiksen yleisyyttä (P = 0,421), diagnostista ryhmää (P = 0,737) sekä veriviljelyn tulosta (P = 0,351) potilaan furiinitasoon. Furiinipitoisuus ja kuolleisuus eivät myöskään liittyneet toisiinsa (P = 0,898). Merkitsevät korrelaatiot löydettiin korkean furiinitason ja tupakoimattomuuden (P = 0,034) sekä reumasairauksien (P < 0,001) väliltä. Furiini ei sovellu infektiomarkkeriksi päivystyspoliklinikalla eikä sen plasmapitoisuudesta voida tehdä johtopäätöksiä liittyen taudin vakavuuteen tai potilaan ennusteeseen. Pitoisuuksien määrittämisestä ei myöskään ole apua oikean mikrobilääkkeen valinnassa. Toisaalta, furiinitasojen jakautumista olisi jatkossa mielenkiintoista tutkia erityisesti reumapotilaista koostuvassa aineistossa.

Subjects/Keywords: biomarkkeri; SIRS; sepsis; tapauskuolleisuus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ranta, N. (2016). The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study . (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/98637

Chicago Manual of Style (16^th Edition):

Ranta, Noora. “The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study .” 2016. Masters Thesis, Tampere University. Accessed January 22, 2021. https://trepo.tuni.fi/handle/10024/98637.

MLA Handbook (7^th Edition):

Ranta, Noora. “The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study .” 2016. Web. 22 Jan 2021.

Vancouver:

Ranta N. The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study . [Internet] [Masters thesis]. Tampere University; 2016. [cited 2021 Jan 22]. Available from: https://trepo.tuni.fi/handle/10024/98637.

Council of Science Editors:

Ranta N. The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room; A prospective cohort study . [Masters Thesis]. Tampere University; 2016. Available from: https://trepo.tuni.fi/handle/10024/98637

Universitat de Valencia

3. León Carsí, Irene María. Estudio comparativo de la respuesta inflamatoria en diferentes estrategias de cirugía de revascularización coronaria .

Degree: 2012, Universitat de Valencia

URL: http://hdl.handle.net/10550/26183

► INTRODUCCIÓN: La Cirugía de Revascularización Coronaria con derivación cardiopulmonar, es causa de una potente respuesta inflamatoria sistémica, que puede afectar a la evolución del postoperatorio.… (more)

▼ INTRODUCCIÓN: La Cirugía de Revascularización Coronaria con derivación cardiopulmonar, es causa de una potente respuesta inflamatoria sistémica, que puede afectar a la evolución del postoperatorio. El objetivo fundamental, ha sido estudiar las diferencias en el comportamiento de la respuesta inflamatoria en las primeras 48 horas del postoperatorio, en la cirugía de revascularización coronaria con circulación extracorpórea convencional, y determinar la modulación de la respuesta inflamatoria cuando se añaden corticoides a la CEC o bien cuando se evita realizando una cirugía sin circulación extracorpórea. MATERIAL Y MÉTODO: Diseñamos un estudio unicéntrico, prospectivo, comparativo. Se incluyeron 68 pacientes sometidos a cirugía de revascularización coronaria de forma programada, y fueron divididos en 3 grupos: Grupo A cirugía de revascularización coronaria sin CEC; Grupo B cirugía de revascularización coronaria con CEC y administración de 1 g metilprednisolona; Grupo C cirugía de revascularización coronaria con CEC. Se analizaron las citocinas séricas proinflamatorias (IL-6, IL-8) y antiinflamatoria (IL-10) mediante ténica ELISA y otros parámetros más inespecíficos inflamatorios (PCR, fibrinógeno y fórmula leucocitaria), en diferentes tiempos T0 (basal), T1 (1h postoperatoria), T2 (24h), T3 (48h). También se analizaron otros biomarcadores como NT-proBNP, troponina T , CPK-MB y ácido láctico y se correlacionaron con la respuesta inflamatoria. Todos los grupos fueron homogéneos en cuanto a sexo, edad, IMC y factores de riesgo cardiovascular. RESULTADOS: La cirugía de revascularización coronaria con circulación extracorpórea y un bolo único de metilprednisolona, fue el grupo que presentó de forma global una respuesta inflamatoria menor en las primeras 48 h del postoperatorio, cuando se comparó con la cirugía cardiaca con circulación extracorpórea sin corticoides y la cirugía sin circulación extracorpórea. En el grupo B se observó un pico IL-10 en T1 (532±151,238 pg/ml) con una p=0,00. Las cifras de IL-6 también fueron menores en todos los tiempos respecto a los otros dos grupos siendo estadísticamente significativas T2 (69,69±51,31) p=0,00 y T3 (56,34±41,96) p=0,00. Los valores de IL-8 fueron menores en el grupo B, especialmente observaron diferencias en T1 (86,47±60,02) con una p=0,037. El ratio IL-6/IL-10 fue menor en el grupo B en todos los tiempos de análisis, p<0,001. Los valores PCR también fueron menores en el grupo B en T1, T2, T3; y el fibrinógeno en T2 y T3, con diferencias significativas. El ácido láctico fue mayor en el grupo B en T1 p=0,00 y T2 p=0,014; no hubo diferencias con el NT-proBNP en los tres grupos; la CPK-MB y Troponina T fueron menores en el grupo sin CEC, siendo estadísticamente significativos en T1 p=0,02; p=0,00. Se encontraron correlaciones positivas en las citoquinas proinflamatorias IL-6 e IL-8, con los biomarcadores, NT-proBNP, troponina T , CPK-MB. CONCLUSIÓN: La administración de 1 g de metilprednisolona tiene la capacidad de modular la respuesta inflamatoria de una forma más… Advisors/Committee Members: Ortega Serrano, Joaquín (advisor).

Subjects/Keywords: cirugía cardiaca; SIRS; inflamación; citoquinas

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APA (6^th Edition):

León Carsí, I. M. (2012). Estudio comparativo de la respuesta inflamatoria en diferentes estrategias de cirugía de revascularización coronaria . (Doctoral Dissertation). Universitat de Valencia. Retrieved from http://hdl.handle.net/10550/26183

Chicago Manual of Style (16^th Edition):

León Carsí, Irene María. “Estudio comparativo de la respuesta inflamatoria en diferentes estrategias de cirugía de revascularización coronaria .” 2012. Doctoral Dissertation, Universitat de Valencia. Accessed January 22, 2021. http://hdl.handle.net/10550/26183.

MLA Handbook (7^th Edition):

León Carsí, Irene María. “Estudio comparativo de la respuesta inflamatoria en diferentes estrategias de cirugía de revascularización coronaria .” 2012. Web. 22 Jan 2021.

Vancouver:

León Carsí IM. Estudio comparativo de la respuesta inflamatoria en diferentes estrategias de cirugía de revascularización coronaria . [Internet] [Doctoral dissertation]. Universitat de Valencia; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10550/26183.

Council of Science Editors:

León Carsí IM. Estudio comparativo de la respuesta inflamatoria en diferentes estrategias de cirugía de revascularización coronaria . [Doctoral Dissertation]. Universitat de Valencia; 2012. Available from: http://hdl.handle.net/10550/26183

4. Tylicki, Jessica Lynn. Comparability of SIRS and SIRS-2 Classifications with External Response Bias Criteria.

Degree: MS, Psychology, 2016, Encompass Digital Archive, Eastern Kentucky University

URL: https://encompass.eku.edu/etd/439

The current study compared the classification groups between the SIRS and SIRS-2 using samples of disability claimants and criminal defendants. Results suggest that the newly revised SIRS-2 may have less clinical utility than the original SIRS. Implications of these results for both clinical and forensic settings are discussed.

Subjects/Keywords: Forensic; Malingering; MMPI-2-RF; SIRS; SIRS-2; Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tylicki, J. L. (2016). Comparability of SIRS and SIRS-2 Classifications with External Response Bias Criteria. (Masters Thesis). Encompass Digital Archive, Eastern Kentucky University. Retrieved from https://encompass.eku.edu/etd/439

Chicago Manual of Style (16^th Edition):

Tylicki, Jessica Lynn. “Comparability of SIRS and SIRS-2 Classifications with External Response Bias Criteria.” 2016. Masters Thesis, Encompass Digital Archive, Eastern Kentucky University. Accessed January 22, 2021. https://encompass.eku.edu/etd/439.

MLA Handbook (7^th Edition):

Tylicki, Jessica Lynn. “Comparability of SIRS and SIRS-2 Classifications with External Response Bias Criteria.” 2016. Web. 22 Jan 2021.

Vancouver:

Tylicki JL. Comparability of SIRS and SIRS-2 Classifications with External Response Bias Criteria. [Internet] [Masters thesis]. Encompass Digital Archive, Eastern Kentucky University; 2016. [cited 2021 Jan 22]. Available from: https://encompass.eku.edu/etd/439.

Council of Science Editors:

Tylicki JL. Comparability of SIRS and SIRS-2 Classifications with External Response Bias Criteria. [Masters Thesis]. Encompass Digital Archive, Eastern Kentucky University; 2016. Available from: https://encompass.eku.edu/etd/439

5. Mathisen, Martine. Sykepleieres ivaretakelse av pasienter med mistenkt sepsis i et akuttmottak.

Degree: Sophiahemmet University, 2016, Sophiahemmet University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2636

► Slik det norske helsevesenet fungerer er oftest sykepleier tettest på pasienten over tid samt er den første til å møte pasienten ved ankomst i… (more)

▼ Slik det norske helsevesenet fungerer er oftest sykepleier tettest på pasienten over tid samt er den første til å møte pasienten ved ankomst i et akuttmottak. Det er sykepleier som triagerer pasienten ved ankomst og det er en sykepleier som gjør de primære undersøkelsene. Kunnskap om SIRS og sepsis er viktig å inneha for og kunne plukke opp tegnene i en tidlig fase og dermed kunne kommunisere funnene til ansvarlig lege slik at behandling kan igangsettes raskt. I tillegg må sykepleiere ha kunnskap om prioriteringen av de viktigste primære behandlingstiltakene som bør igangsettes hos pasienter med mistanke om sepsis. Kommunikasjon er også viktig opp mot pasienten for jevnlig å kunne vurdere pasientens tilstand og en eventuelt forverring. Om strukturerte metoder for bedømming ikke er tilstede hos ansvarlig sykepleier kan dette få store konsekvenser for pasienten ved at sepsis kan utvikle seg til alvorlig sepsis eller septisk sjokk som har høy mortalitet. Hensikten med studien var å undersøke sykepleieres ivaretakelse av pasienter med mistenkt sepsis i et akuttmottak. Metoden var kvantitativ og data ble samlet inn ved hjelp av en spørreundersøkelse på ett akuttmottak hvor 36 sykepleiere besvarte skjemaet. Den innsamlede dataen ble analysert ved hjelp av deskriptiv statistikk og presentert i prosentform i tabell, diagrammer og løpende tekst. Resultatet viste at en stor andel av sykepleierne hadde god kunnskap om evidensbasert forskning og benyttet denne så vel som i undersøkelsen som i behandlingen av pasienten med mistenkt sepsis. Det kom samtidig frem at så mange som ca. 30 prosent ikke var sikre på hva SIRS kriteriene er og hva som er definisjonen på sepsis. Åtti prosent var sikre på primære behandlingstiltak, mens 20 prosent var usikre. Dette viser at det er behov for forbedring. Videre viser undersøkelsen at 75 prosent mener at triage er et godt verktøy for å oppdage mistanke om sepsis i en tidlig fase. I all hovedsak viste undersøkelsen at det var oppfattet å være god kommunikasjonen både mellom sykepleier og lege samt mellom sykepleier og pasient. Konklusjonen var at det var en høy andel sykepleiere i avdelingen som har god kunnskap om evidensbasert forskning samt lokale og internasjonale retningslinjer for både ivaretakelse og behandling av pasienter med sepsis. Sykepleierne visste hvilke kriterier de skal se etter for å oppdage sepsis i en tidlig fase samt hvilke målinger og tiltak som burde gjøres for å unngå utviklingen av alvorlig sepsis og septisk sjokk. Det er allikevel fortsatt rom for forbedringspotensialet da det burde være tett opp mot 100 prosent som sitter inne med denne kunnskapen. Kommunikasjonen mellom sykepleier og lege ved behandling av pasienter med mistenkt sepsis viste seg å oppfattes som god, bortsett fra ved bruk av medisinsk team hvor det fremgikk at ikke alles roller var godt nok kjent. Når det gjelder kommunikasjonen mellom sykepleier og pasient ble denne oppfattet god fra sykepleiers side ved at de hadde tid til å formidle trygghet…

Subjects/Keywords: SIRS; Sepsis; Emergency department; Communication; SIRS; Sepsis; Akuttmottak; Kommunikasjon; Nursing; Omvårdnad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mathisen, M. (2016). Sykepleieres ivaretakelse av pasienter med mistenkt sepsis i et akuttmottak. (Thesis). Sophiahemmet University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mathisen, Martine. “Sykepleieres ivaretakelse av pasienter med mistenkt sepsis i et akuttmottak.” 2016. Thesis, Sophiahemmet University. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mathisen, Martine. “Sykepleieres ivaretakelse av pasienter med mistenkt sepsis i et akuttmottak.” 2016. Web. 22 Jan 2021.

Vancouver:

Mathisen M. Sykepleieres ivaretakelse av pasienter med mistenkt sepsis i et akuttmottak. [Internet] [Thesis]. Sophiahemmet University; 2016. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mathisen M. Sykepleieres ivaretakelse av pasienter med mistenkt sepsis i et akuttmottak. [Thesis]. Sophiahemmet University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

6. Kovács, Lilla. A szisztémás gyulladásos válaszreakció és a súlyos szepszis kezelésének lehetőségei .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/230301

► Világszerte óriási problémát jelent a szisztémás gyulladásos válaszreakció és az ezzel asszociált kórképek (acut pancreatitis, szepszis, égés, polytrauma stb.) megfelelő kezelése. Mai napig az intenzív… (more)

Subjects/Keywords: SIRS; szepszis; immunmoduláció

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APA (6^th Edition):

Kovács, L. (n.d.). A szisztémás gyulladásos válaszreakció és a súlyos szepszis kezelésének lehetőségei . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/230301

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kovács, Lilla. “A szisztémás gyulladásos válaszreakció és a súlyos szepszis kezelésének lehetőségei .” Thesis, University of Debrecen. Accessed January 22, 2021. http://hdl.handle.net/2437/230301.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kovács, Lilla. “A szisztémás gyulladásos válaszreakció és a súlyos szepszis kezelésének lehetőségei .” Web. 22 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Kovács L. A szisztémás gyulladásos válaszreakció és a súlyos szepszis kezelésének lehetőségei . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2437/230301.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Kovács L. A szisztémás gyulladásos válaszreakció és a súlyos szepszis kezelésének lehetőségei . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/230301

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

7. Coelho, Ana Maria de Mendonça. Mecanismos de ação da solução salina hipertônica na pancreatite aguda experimental.

Degree: PhD, Cirurgia do Aparelho Digestivo, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5154/tde-07052010-170926/ ;

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INTRODUÇÃO: A pancreatite aguda (PA) grave é um processo inflamatório do pâncreas caracterizado por alterações hemodinâmicas e resposta inflamatória sistêmica com altos níveis de mortalidade.… (more)

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INTRODUÇÃO: A pancreatite aguda (PA) grave é um processo inflamatório do pâncreas caracterizado por alterações hemodinâmicas e resposta inflamatória sistêmica com altos níveis de mortalidade. A ativação inapropriada intrapancreática das enzimas pancreáticas desempenha papel importante no desencadeamento dos mecanismos inflamatórios responsáveis pelas manifestações locais e sistêmicas da doença. Em trabalho anterior observamos redução significativa da mortalidade após administração de solução salina hipertônica em ratos, através de redução das alterações hemodinâmicas e da resposta inflamatória sistêmica, mas os efeitos da solução salina hipertônica na ativação das enzimas pancreáticas e na própria lesão pancreática não foram estudados. O objetivo deste estudo foi avaliar se o mecanismo de ação da solução salina hipertônica, reduzindo a gravidade da pancreatite aguda em ratos, ocorre devido à redução da intensidade da lesão pancreática e/ou à redução da resposta inflamatória sistêmica e seus efeitos. MÉTODOS: Foi utilizado um modelo experimental de pancreatite aguda grave através da injeção intraductal de taurocolato de sódio a 2,5%. Cento e quarenta e dois ratos Wistar machos foram divididos em quatro grupos: Controle (animais que não foram submetidos à indução da PA), Grupo ST (animais que não receberam tratamento após a indução da PA), Grupo SSF (animais que receberam 34ml/Kg de solução salina fisiológica de NaCl 0,9% por via endovenosa, 1 hora após a indução da PA) e grupo SSH (animais que receberam 4ml/Kg de solução salina hipertônica de NaCl 7,5% por via endovenosa, 1 hora após a indução da PA). Após 2, 12 e 24 horas da indução da PA os animais foram sacrificados e os materiais foram coletados para análise. Foram efetuadas a quantificação do volume de líquido ascítico e as determinações no líquido ascítico e no soro dos peptídeos liberados na ativação do tripsinogênio (TAP) e da atividade da amilase. No tecido pancreático foram realizadas as análises da peroxidação lipídica (MDA), da atividade da mieloperoxidase (MPO) e a análise histológica. Os níveis de citocinas (TNF-, IL-6 e IL-10) foram analisados no líquido ascítico, soro e tecido pancreático. RESULTADOS: Os níveis de TAP e amilase no líquido ascítico e soro, de MDA e MPO no tecido pancreático e a análise histológica mostraram resultados iguais nos três grupos de animais que foram submetidos a PA (ST, SSF e SSH). Observamos redução do volume de líquido ascítico e dos níveis de TNF- , IL-6 e IL-10 no líquido ascítico, soro e tecido pancreático nos animais nos quais foi administrada solução salina hipertônica (grupo SSH) quando comparados com os animais tratados com solução salina fisiológica (grupo SSF) e os animais sem tratamento (grupo ST) (p<0,05). CONCLUSÕES: A administração de solução salina hipertônica (NaCl 7,5%) na pancreatite aguda experimental foi capaz de reduzir a resposta inflamatória local e sistêmica, sem modificar contudo a intensidade das lesões pancreáticas.

INTRODUCTION: Severe acute pancreatitis (AP) is characterized by hemodynamic…

Advisors/Committee Members: Jukemura, José.

Subjects/Keywords: Citocinas; Cytokines; Inflamação; Inflammation; Pancreatite; Pancreatitis; Saline solution hypertonic; SIRS; SIRS; Solução salina hipertônica

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Coelho, A. M. d. M. (2010). Mecanismos de ação da solução salina hipertônica na pancreatite aguda experimental. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5154/tde-07052010-170926/ ;

Chicago Manual of Style (16^th Edition):

Coelho, Ana Maria de Mendonça. “Mecanismos de ação da solução salina hipertônica na pancreatite aguda experimental.” 2010. Doctoral Dissertation, University of São Paulo. Accessed January 22, 2021. http://www.teses.usp.br/teses/disponiveis/5/5154/tde-07052010-170926/ ;.

MLA Handbook (7^th Edition):

Coelho, Ana Maria de Mendonça. “Mecanismos de ação da solução salina hipertônica na pancreatite aguda experimental.” 2010. Web. 22 Jan 2021.

Vancouver:

Coelho AMdM. Mecanismos de ação da solução salina hipertônica na pancreatite aguda experimental. [Internet] [Doctoral dissertation]. University of São Paulo; 2010. [cited 2021 Jan 22]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5154/tde-07052010-170926/ ;.

Council of Science Editors:

Coelho AMdM. Mecanismos de ação da solução salina hipertônica na pancreatite aguda experimental. [Doctoral Dissertation]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/5/5154/tde-07052010-170926/ ;

8. Rodrigues, Luís Miguel Manita. Coagulopathy in sepsis and the prognostic value of abnormal coagulation times.

Degree: 2017, Universidade de Évora

URL: https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/21771

► Sepsis is a hard to define condition associated with the deleterious systemic inflammatory response syndrome (SIRS) which ultimately leads to the failure of multiple organs.… (more)

▼ Sepsis is a hard to define condition associated with the deleterious systemic inflammatory response syndrome (SIRS) which ultimately leads to the failure of multiple organs. The mediators released throughout this exaggerated inflammatory reaction activate coagulation pathways and generate a dysfunctional response that results in coagulopathy. The present dissertation includes a literature review regarding the subject of sepsis and associated coagulopathy, along with a study that primarily aims to investigate the use of abnormal coagulation times as biological markers of coagulation dysfunction and as predictors of outcome in veterinary patients who are at risk of developing sepsis. The results suggest that pairing coagulation time data with an organ failure scoring system may be advantageous in the prediction of outcome. Furthermore, critically ill patients should be given a five-day time frame following admission before euthanasia is considered, as most tend to survive their illnesses once they get past this period; RESUMO: COAGULOPATIA NA SÉPSIS E O VALOR DE PROGNÓSTICO DE TEMPOS DE COAGULAÇÃO ALTERADOS A sépsis é uma síndrome de difícil definição e que está associada à síndrome da resposta inflamatória sistémica (SIRS) que leva à falha de múltiplos órgãos. Os mediadores libertados durante esta reação inflamatória exagerada levam à ativação disfuncional da coagulação sanguínea, o que resulta em coagulopatia. A presente dissertação inclui uma revisão bibliográfica sobre o tema da sépsis e a coagulopatia associada, bem como um estudo cujo objetivo primário é o de investigar a utilização de tempos de coagulação alterados, tanto como marcadores biológicos de disfunção da coagulação sanguínea bem como fatores de prognóstico em pacientes veterinários em risco de sépsis. Os resultados do estudo realizado mostram vantagem em associar a avaliação dos tempos de coagulação com sistemas de pontuação de falha orgânica para a realização do prognóstico. Estes sugerem também que os pacientes críticos que ultrapassam os primeiros cinco dias após a sua admissão hospitalar tendem a sobreviver. Advisors/Committee Members: Branco, Sandra Maria da Silva, Martins, Ângela.

Subjects/Keywords: Sepsis; Coagulation; SIRS; Emergency; Critical care; Sépsis; Coagulação; SIRS; Urgências; Cuidados intensivos

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodrigues, L. M. M. (2017). Coagulopathy in sepsis and the prognostic value of abnormal coagulation times. (Thesis). Universidade de Évora. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/21771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rodrigues, Luís Miguel Manita. “Coagulopathy in sepsis and the prognostic value of abnormal coagulation times.” 2017. Thesis, Universidade de Évora. Accessed January 22, 2021. https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/21771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rodrigues, Luís Miguel Manita. “Coagulopathy in sepsis and the prognostic value of abnormal coagulation times.” 2017. Web. 22 Jan 2021.

Vancouver:

Rodrigues LMM. Coagulopathy in sepsis and the prognostic value of abnormal coagulation times. [Internet] [Thesis]. Universidade de Évora; 2017. [cited 2021 Jan 22]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/21771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rodrigues LMM. Coagulopathy in sepsis and the prognostic value of abnormal coagulation times. [Thesis]. Universidade de Évora; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/21771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Ferreira, André de Brito Cavaco. Clínica e cirurgia de animais de companhia.

Degree: 2017, Universidade de Évora

URL: https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/22430

► Este relatório foi elaborado no âmbito do estágio curricular efetuado no Hospital Veterinário Muralha de Évora, que decorreu entre 1 de Outubro de 2016 e… (more)

Subjects/Keywords: SIRS; Sepsis; MODS; Inflamação; Paciente crítico; SIRS; Sepsis; MODS; Inflammation; Critical patient

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferreira, A. d. B. C. (2017). Clínica e cirurgia de animais de companhia. (Thesis). Universidade de Évora. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/22430

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferreira, André de Brito Cavaco. “Clínica e cirurgia de animais de companhia.” 2017. Thesis, Universidade de Évora. Accessed January 22, 2021. https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/22430.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferreira, André de Brito Cavaco. “Clínica e cirurgia de animais de companhia.” 2017. Web. 22 Jan 2021.

Vancouver:

Ferreira AdBC. Clínica e cirurgia de animais de companhia. [Internet] [Thesis]. Universidade de Évora; 2017. [cited 2021 Jan 22]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/22430.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferreira AdBC. Clínica e cirurgia de animais de companhia. [Thesis]. Universidade de Évora; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:dspace.uevora.pt:10174/22430

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Souza Fonseca Guimaraes, Fernando de. Natural killer cells responsiveness to Toll-like receptor agonists during bacterial sepsis : Les cellules de l’immunité innée sensibles aux récepteurs Toll-like au cours d’une infection bactérienne.

Degree: Docteur es, Immunologie, 2012, Université Paris Descartes – Paris V

URL: http://www.theses.fr/2012PA05T049

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Au cours d’une infection, les cellules de l’immunité innée sont capables de reconnaître via les Toll-like receptors (TLR) des motifs appelés pathogen-associated molecular patterns. Les… (more)

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Au cours d’une infection, les cellules de l’immunité innée sont capables de reconnaître via les Toll-like receptors (TLR) des motifs appelés pathogen-associated molecular patterns. Les cellules natural killer (NK) contribuent au processus inflammatoire en produisant de nombreuses cytokines. Chez la souris, nous avons montré que l’expression du TLR2 et du TLR4 dans les cellules NK spléniques est intracellulaire, comme pour le TLR9. La réponse des NK aux agonistes des TLR2, 4 et 9 nécessite la présence de cytokines accessoires (IL-15 et IL-18), afin d’obtenir une production significative des cytokines pro-inflammatoires IFN- et GM-CSF. En revanche, dans un modèle de sepsis polymicrobial, les NK spléniques de souris présentent une diminution dramatique de leur production d’IFN- et de GM-CSF en réponse aux agonistes des TLR. Cette diminution est sous le contrôle des cellules T régulatrices (Treg) et due au TGF-1. L’analyse des voies de signalisation nous a permis de montrer que la production de GM-CSF est abolie chez les cellules NK de souris déficientes pour STING en réponse au CpG-DNA. Ces résultats mettent en lumière une voie alternative et cytoplasmique pour la détection de l’ADN bactérien dans les cellules NK, différente de la voie classique TLR9-MyD88 dépendante. De plus, nous avons montré un trafic du récepteur TLR2 depuis l’intérieur vers la surface des cellules NK. La migration du TLR2 à la surface des NK nécessite la molécule UNC93B1, précédemment décrite comme transporteur endosomal de TLR.Chez les cellules NK humaines circulantes (sous-populations CD3-CD56bright et CD3-CD56dim), nous avons montré que l’expression des TLR2 et 4 est majoritairement intracellulaire, comme pour le TLR9 et comme chez la souris. La production d’IFN- par les NK de sujets sains en réponse aux agonistes des TLR nécessite également la présence de cytokines accessoires. Nous montrons que cette production est fortement altérée pour les NK des patients admis en soins intensifs et ayant un sepsis ou un syndrome de réponse inflammatoire systémique (SIRS). De même nous avons trouvé des différences entre les patients et les sujets sains dans l’expression du CD69 (marqueur d’activation précoce) et des TLR eux-mêmes. Cette étude indique que les NK des patients sepsis et SIRS deviennent tolérants aux agonistes des TLR en terme de production d’IFN-, de manière similaire à ce qui a été décrit pour d’autres cellules comme les monocytes

As sensors of infection, innate immune cells are able to recognize pathogen-associated molecular patterns by receptors such as Toll-like receptors (TLR). NK cells contribute to inflammatory processes by the production of numerous cytokines. In mice, we have shown that the protein expression of TLR2 and TLR4 in naive NK cells from spleen is predominantly intracellular, similarly to TLR9. The responsiveness of purified NK cells to TLR2, 4 or 9 agonists in vitro requires the presence of accessory cytokines (IL-15 and 18) to trigger a significant production of IFN- and GM-CSF. In contrast, NK cells purified from…

Advisors/Committee Members: Adib-Conquy, Minou (thesis director).

Subjects/Keywords: TLR; IFN-y; GM-CSF; SIRS; UNC93B1; STING; NK cell; TLR; Sepsis; SIRS; STING

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza Fonseca Guimaraes, F. d. (2012). Natural killer cells responsiveness to Toll-like receptor agonists during bacterial sepsis : Les cellules de l’immunité innée sensibles aux récepteurs Toll-like au cours d’une infection bactérienne. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2012PA05T049

Chicago Manual of Style (16^th Edition):

Souza Fonseca Guimaraes, Fernando de. “Natural killer cells responsiveness to Toll-like receptor agonists during bacterial sepsis : Les cellules de l’immunité innée sensibles aux récepteurs Toll-like au cours d’une infection bactérienne.” 2012. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed January 22, 2021. http://www.theses.fr/2012PA05T049.

MLA Handbook (7^th Edition):

Souza Fonseca Guimaraes, Fernando de. “Natural killer cells responsiveness to Toll-like receptor agonists during bacterial sepsis : Les cellules de l’immunité innée sensibles aux récepteurs Toll-like au cours d’une infection bactérienne.” 2012. Web. 22 Jan 2021.

Vancouver:

Souza Fonseca Guimaraes Fd. Natural killer cells responsiveness to Toll-like receptor agonists during bacterial sepsis : Les cellules de l’immunité innée sensibles aux récepteurs Toll-like au cours d’une infection bactérienne. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2012. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2012PA05T049.

Council of Science Editors:

Souza Fonseca Guimaraes Fd. Natural killer cells responsiveness to Toll-like receptor agonists during bacterial sepsis : Les cellules de l’immunité innée sensibles aux récepteurs Toll-like au cours d’une infection bactérienne. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2012. Available from: http://www.theses.fr/2012PA05T049

11. Monteiro Sousa, Claudio. Exploration transcriptomique et logique de la voie TLR4 dans le contexte physiopathologique du sepsis : Transcriptomic and logic exploration of the TLR4 signaling pathway in the pathophysiology context of sepsis.

Degree: Docteur es, Biomathématiques. Bioinformatique. Génomique évolutive, 2016, Lyon

URL: http://www.theses.fr/2016LYSE1098

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Le sepsis est un syndrome observé chez des patients associant une infection documentée (microbiologiquement ou cliniquement suspectée) à une réponse inflammatoire systémique (Systemic Inflammatory Response… (more)

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Le sepsis est un syndrome observé chez des patients associant une infection documentée (microbiologiquement ou cliniquement suspectée) à une réponse inflammatoire systémique (Systemic Inflammatory Response Syndrome : SIRS).Celui-ci peut évoluer vers un sepsis sévère s'il est associé à la défaillance d'un ou de plusieurs organes. Le choc septique est l'association d'un état septique grave et d'une défaillance hémodynamique caractérisée par une chute aiguë de la pression artérielle ne pouvant pas être corrigée par une procédure standard de remplissage vasculaire. Les syndromes septiques sont aujourd'hui la première cause de mortalité en unités de réanimation. Cette mortalité élevée, en particulier pour les cas les plus graves tels que les chocs septiques, témoigne d'une absence de traitements curatifs pour cette pathologie. Partant de l'hypothèse que les syndromes septiques graves sont la conséquence d'une perte de contrôle précoce de la régulation de la réponse inflammatoire, nous avons étudié, via deux démarches complémentaires, l'initiation de la voie de signalisation TLR4 et les mécanismes intracellulaires contribuant à sa régulation. Dans un premier temps, l'utilisation d'approches transcriptomiques nous a permis d'identifier la voie de signalisation mTOR comme discriminante entre des patients sains (SIRS induit par l'injection d'endotoxines) et des patients souffrant de syndromes septiques graves. Nous avons ensuite développé et utilisé des techniques de modélisation logique pour simuler in silico le rôle joué par la voie mTOR dans la résolution d'une réponse inflammatoire. Ces résultats encourageants ouvrent des perspectives pour de nouvelles applications thérapeutiques dans le domaine du sepsis

Sepsis is a syndrome observed in patients combining a documented infection (microbiologically or clinically suspected) with a systemic inflammatory response (Systemic Inflammatory Response Syndrome : SIRS). It may progress to severe sepsis if it is associated with failures of one or more organs. Septic shock is the combination of a severe sepsis and a hemodynamic dysfunction characterized by an acute fall in blood pressure that cannot be corrected by a procedure of vascular filling.Sepsis syndromes represent today the first cause of mortality in intensive care units around the world. This poor survival rate, in particular for the most severe cases, such as septic shock, testifies a real curative therapeutic demand.Based on the assumption that severe sepsis syndromes are the consequence of a loss of control in early mechanisms of inflammatory response regulation, we studied via two complementary approaches the initiation of TLR4 signaling pathway and the intracellular mechanisms contributing to its regulation.First, the use of transcriptomic approaches allowed us to identify the mTOR signaling pathway as discriminating between healthy patients (SIRS induced by the infusion of endotoxins) and patients with severe septic syndromes. We then developed and used logic modeling approaches to in silico simulate the role played…

Advisors/Committee Members: Gueyffier, François (thesis director), Tod, Michel (thesis director).

Subjects/Keywords: SIRS; Sepsis; Modélisation; Physiopathologie; Transcriptome; Logique booléenne; Logique floue; SIRS; Sepsis; Modeling; Pathophysiology; Transcriptome; Boolean logic; Fuzzy logic; 570.15

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Monteiro Sousa, C. (2016). Exploration transcriptomique et logique de la voie TLR4 dans le contexte physiopathologique du sepsis : Transcriptomic and logic exploration of the TLR4 signaling pathway in the pathophysiology context of sepsis. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2016LYSE1098

Chicago Manual of Style (16^th Edition):

Monteiro Sousa, Claudio. “Exploration transcriptomique et logique de la voie TLR4 dans le contexte physiopathologique du sepsis : Transcriptomic and logic exploration of the TLR4 signaling pathway in the pathophysiology context of sepsis.” 2016. Doctoral Dissertation, Lyon. Accessed January 22, 2021. http://www.theses.fr/2016LYSE1098.

MLA Handbook (7^th Edition):

Monteiro Sousa, Claudio. “Exploration transcriptomique et logique de la voie TLR4 dans le contexte physiopathologique du sepsis : Transcriptomic and logic exploration of the TLR4 signaling pathway in the pathophysiology context of sepsis.” 2016. Web. 22 Jan 2021.

Vancouver:

Monteiro Sousa C. Exploration transcriptomique et logique de la voie TLR4 dans le contexte physiopathologique du sepsis : Transcriptomic and logic exploration of the TLR4 signaling pathway in the pathophysiology context of sepsis. [Internet] [Doctoral dissertation]. Lyon; 2016. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2016LYSE1098.

Council of Science Editors:

Monteiro Sousa C. Exploration transcriptomique et logique de la voie TLR4 dans le contexte physiopathologique du sepsis : Transcriptomic and logic exploration of the TLR4 signaling pathway in the pathophysiology context of sepsis. [Doctoral Dissertation]. Lyon; 2016. Available from: http://www.theses.fr/2016LYSE1098

Universidade do Rio Grande do Sul

12. Dal Ponte, Silvana Teixeira. Valor diagnóstico e prognóstico do CD64 na sepse.

Degree: 2015, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/129642

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INTRODUÇÃO: A sepse é uma resposta inflamatória sistêmica causada por infecção suspeita ou confirmada. As avaliações clínicas são essenciais para a sua detecção e tratamento… (more)

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INTRODUÇÃO: A sepse é uma resposta inflamatória sistêmica causada por infecção suspeita ou confirmada. As avaliações clínicas são essenciais para a sua detecção e tratamento precoce. Hemoculturas podem demorar até dois dias para produzir um resultado, e nem sempre são confiáveis. No entanto, estudos recentes sugeriram que a expressão de CD64 de neutrófilos pode ser uma alternativa sensível e específica para o diagnóstico de uma infecção sistêmica. OBJETIVO: Analisar a diferença de valores entre CD64 de indivíduos com síndrome de resposta inflamatória sistêmica (SIRS), e sepse suspeita ou confirmada, que satisfazem os critérios de diagnóstico para SIRS ao chegar na unidade de emergência. MÉTODO: Este foi um estudo de coorte prospectivo observacional. A amostra foi composta de 109 pacientes com idade de 18 anos ou mais, com critérios de SIRS na chegada ao serviço de emergência. Expressão CD64 foi medida no prazo de 6 horas de internação, e novamente após 48 h. RESULTADOS: A análise da curva ROC sugeriu que um corte de 1.45 dos níveis de CD64 poderia diagnosticar sepse com uma sensibilidade de 0,85, especificidade de 0,75, uma precisão de 82,08%, um valor preditivo positivo de 0,964, um valor preditivo negativo de 0,375 e uma razão de verossimilhança de 3,3381. A área sob a curva foi de 0,832. CONCLUSÃO: CD64 parece ser útil como biomarcador, sensível e específico para discriminar entre SRIS e sépsis.

INTRODUCTION: Sepsis is a systemic inflammatory response to suspected or confirmed infection. Clinical evaluations are essential for its early detection and treatment. Blood cultures may take as long as two days to yield a result, and are not always reliable. However, recent studies have suggested that neutrophil CD64 expression may be a sensitive and specific alternative for the diagnosis of systemic infection. OBJECTIVE: To analyze the difference in CD64 values between subjects with systemic inflammatory response syndrome (SIRS), suspected or confirmed sepsis, who meet diagnostic criteria for SIRS upon arriving at an emergency unit. METHOD: This was a prospective observational cohort study. The sample consisted of 109 patients aged 18 years with criteria for SIRS on arrival to Emergency department. CD64 expression was measured within 6 hours of hospital admission, and once again after 48 h. RESULTS: ROC curve analysis suggested that a cutoff of 1.45 for CD64 expression could diagnose sepsis with a sensitivity of 0.85, a specificity of 0.75, an accuracy of 82.08%, a positive predictive value of 0.964, a negative predictive value of 0.375 and a positive likelihood ratio of 3.3381. The area under the curve was 0.832. CONCLUSION: CD64 appears to be a useful, sensitive and specific biomarker in discriminating between SIRS and sepsis.

Advisors/Committee Members: Goldani, Luciano Zubaran.

Subjects/Keywords: SIRS; Receptores de IgG; Sepsis; Sepse; Biomarkers; CD64

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dal Ponte, S. T. (2015). Valor diagnóstico e prognóstico do CD64 na sepse. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/129642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dal Ponte, Silvana Teixeira. “Valor diagnóstico e prognóstico do CD64 na sepse.” 2015. Thesis, Universidade do Rio Grande do Sul. Accessed January 22, 2021. http://hdl.handle.net/10183/129642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dal Ponte, Silvana Teixeira. “Valor diagnóstico e prognóstico do CD64 na sepse.” 2015. Web. 22 Jan 2021.

Vancouver:

Dal Ponte ST. Valor diagnóstico e prognóstico do CD64 na sepse. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10183/129642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dal Ponte ST. Valor diagnóstico e prognóstico do CD64 na sepse. [Thesis]. Universidade do Rio Grande do Sul; 2015. Available from: http://hdl.handle.net/10183/129642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Fonseca, João Pedro Montenegro Máximo. Importância da PCT no Diagnóstico de Sépsis em Pacientes Oncológicos Internados na UCI.

Degree: 2016, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2542

► No presente estudo foi avaliado o comportamento de biomarcadores na condição de sépsis, numa série de doentes internados entre 2012 e 2013 na Unidade de… (more)

▼ No presente estudo foi avaliado o comportamento de biomarcadores na condição de sépsis, numa série de doentes internados entre 2012 e 2013 na Unidade de Cuidados Intensivos (UCI) do Instituto Português de Oncologia do Porto Francisco Gentil (IPOPFG). O objetivo principal do mesmo foi associar os valores séricos dos biomarcadores como a Procalcitonina (PCT), Proteína-C reativa (PCR) e contagem de Leucócitos (WBC) com o diagnóstico de sépsis. Para tal foi necessário alcançar outros objetivos: analisar os resultados de PCT, PCR e WBC na série de doentes em estudo; estudar a associação entre os valores destes biomarcadores com os resultados microbiológicos, nomeadamente com as hemoculturas; avaliar a sensibilidade e especificidade dos valores cut off de PCT, PCR e WBC, adotados pela Instituição, para a condição de sépsis. Do total de 273 pacientes incluídos neste estudo, foram selecionados para análise estatística 225 com exame microbiológico realizado e não sujeitos a transplante de medula óssea. Da análise dos resultados foi possível concluir que tanto a PCT como a PCR, estavam associadas com o diagnóstico precoce de sépsis. A contagem de WBC revelou não ser uma mais valia para este diagnóstico. Nenhum biomarcador em estudo revelou uma associação estatisticamente significativa para os agentes microbiológicos, registando-se, no entanto, um ligeiro aumento das bactérias Gram-negativas nos casos com PCT alta. Verificou-se também que em relação aos produtos microbiológicos, particularmente para as hemoculturas, mais de metade dos casos com PCT alta revelaram hemoculturas negativas apesar do diagnóstico de sépsis. A análise da sensibilidade e especificidade dos vários biomarcadores, revelou que apenas a PCT apresentou um comportamento estatisticamente satisfatório (AUC de 0,788) possibilitando, ao diagnóstico, a distinção entre sépsis e SIRS. Neste sentido, o valor cut off em uso nesta Instituição para esta variável, revelou para a PCT baixa uma sensibilidade e especificidade de 0,811 e 0,543 respetivamente, e para PCT alta uma sensibilidade e especificidade de 0,632 e 0,853, respetivamente. O cut off da PCT (19ng/mL), encontrado neste estudo, revelou ser um coadjuvante no diagnóstico de sépsis com capacidade de orientar de uma forma mais precisa qual o agente etiológico causador desta infeção, uma vez que: todos os pacientes com concentrações de PCT acima deste valor apresentaram o diagnóstico de sépsis e, na sua grande maioria (80,7%), estavam associados a infeções por bactérias Gram-negativas, especialmente, Enterobacteriaceae Advisors/Committee Members: Sousa, Carlos Alberto Palmeira de.

Subjects/Keywords: Biomarcadores; PCT; Sépsis; SIRS; UCI; Gram-negativas; Enterobacteriaceae

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fonseca, J. P. M. M. (2016). Importância da PCT no Diagnóstico de Sépsis em Pacientes Oncológicos Internados na UCI. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2542

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fonseca, João Pedro Montenegro Máximo. “Importância da PCT no Diagnóstico de Sépsis em Pacientes Oncológicos Internados na UCI.” 2016. Thesis, RCAAP. Accessed January 22, 2021. https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2542.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fonseca, João Pedro Montenegro Máximo. “Importância da PCT no Diagnóstico de Sépsis em Pacientes Oncológicos Internados na UCI.” 2016. Web. 22 Jan 2021.

Vancouver:

Fonseca JPMM. Importância da PCT no Diagnóstico de Sépsis em Pacientes Oncológicos Internados na UCI. [Internet] [Thesis]. RCAAP; 2016. [cited 2021 Jan 22]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2542.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fonseca JPMM. Importância da PCT no Diagnóstico de Sépsis em Pacientes Oncológicos Internados na UCI. [Thesis]. RCAAP; 2016. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2542

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Commonwealth University

14. Henry, Courtney. Population Based Model of Gonorrhea and Interventions Against Increased Antibiotic Resistance.

Degree: MS, Mathematical Sciences, 2012, Virginia Commonwealth University

URL: https://doi.org/10.25772/6AMZ-TH61 ; https://scholarscompass.vcu.edu/etd/2784

► Gonnorrhea is an infectious sexually transmitted disease (STD) caused by the bacterium Neisseria gonorrhoeae that commonly reproduces in the reproductive tract.The Centers of Disease Control… (more)

Subjects/Keywords: gonorrhea; STD; epidemiology; SIR; SIRS; Physical Sciences and Mathematics

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APA (6^th Edition):

Henry, C. (2012). Population Based Model of Gonorrhea and Interventions Against Increased Antibiotic Resistance. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/6AMZ-TH61 ; https://scholarscompass.vcu.edu/etd/2784

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Henry, Courtney. “Population Based Model of Gonorrhea and Interventions Against Increased Antibiotic Resistance.” 2012. Thesis, Virginia Commonwealth University. Accessed January 22, 2021. https://doi.org/10.25772/6AMZ-TH61 ; https://scholarscompass.vcu.edu/etd/2784.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Henry, Courtney. “Population Based Model of Gonorrhea and Interventions Against Increased Antibiotic Resistance.” 2012. Web. 22 Jan 2021.

Vancouver:

Henry C. Population Based Model of Gonorrhea and Interventions Against Increased Antibiotic Resistance. [Internet] [Thesis]. Virginia Commonwealth University; 2012. [cited 2021 Jan 22]. Available from: https://doi.org/10.25772/6AMZ-TH61 ; https://scholarscompass.vcu.edu/etd/2784.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Henry C. Population Based Model of Gonorrhea and Interventions Against Increased Antibiotic Resistance. [Thesis]. Virginia Commonwealth University; 2012. Available from: https://doi.org/10.25772/6AMZ-TH61 ; https://scholarscompass.vcu.edu/etd/2784

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

15. McIlroy, Daniel. The role of mitochondrial DNA in the post-injury inflammatory response following major trauma.

Degree: PhD, 2018, University of Newcastle

URL: http://hdl.handle.net/1959.13/1389042

►

Research Doctorate - Doctor of Philosophy (PhD)

Trauma is the leading cause of death in the developed world in those aged under 45 years. The… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Trauma is the leading cause of death in the developed world in those aged under 45 years. The main potentially modifiable cause of late death after injury is post-injury multiple organ failure (MOF). Early MOF is characterised by a lethal combination of systemic inflammatory response syndrome (SIRS) which underpinned by neutrophil proliferation and “priming” as a result of the initial injury and haemorrhagic shock. If primed neutrophils are then exposed to “second hit” then dysregulated neutrophil driven inflammation can occur, resulting in end organ sequestration, parenchymal damage, MOF and ultimately death. Interest has increased in endogenous drivers of the innate immune system that exert a potent pro-inflammatory effect by activating pathogen recognition receptors (PRR’s), which are designed to respond to pathogen associated molecular patterns (PAMPs) found in bacteria. Endogenous factors that can trigger this response in the absence of sepsis have been termed “alarmins” or damage associated molecular patterns (DAMPs). Mitochondrial DNA (mtDNA) is a potently proinflammatory DAMP, which has been found to be highly elevated in the post-injury state. Mitochondrial DAMPs have also been associated with neutrophil mediated end organ injury. Primary aims: The primary aim of this thesis was to characterise the effect of post-injury non-life saving orthopaedic surgery on circulating mtDNA levels. No study had looked at the effect of surgical intervention on levels of mtDNA after initial injury and possible sources of mtDNA release. Initially a pilot study of 35 trauma patients who subsequently underwent orthopaedic surgery was performed primarily measuring cell-free mtDNA and nuclear DNA (nDNA) with sequential plasma measurements over a 5-day perioperative period with comparison to 20 healthy control subjects. MtDNA levels continued to rise over the 5-day observation period following surgery and had no correlation to markers of cell-necrosis either in the form of direct musculoskeletal injury, or secondary inflammatory end organ injury. Whilst nDNA levels were elevated when compared to healthy controls no increase was observed in the 5-day observation period. Elevated mtDNA perioperative levels were directly correlated with the magnitude and early timing of surgical intervention. MtDNA levels were inversely proportional to the volume of crystalloid infused indicating a possible role for adequate resuscitation in modulating circulating mtDNA levels. A positive trend between mtDNA levels and incidence of post injury SIRS and MOF was observed but this failed to reach statistical significance. This lead to the genesis of the hypothesis that the persistently elevated mtDNA levels may have a primary inflammatory source. Secondary aims: The secondary aims of this thesis were threefold. Firstly, to determine whether there was a primary inflammatory source of mtDNA, namely focussing on possible neutrophil extracellular trap (NET) formation or “NETosis”. Secondly, to determine…

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: SIRS; MOF; mtDNA; DNase; NETs; trauma; injury; thesis by publication

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APA (6^th Edition):

McIlroy, D. (2018). The role of mitochondrial DNA in the post-injury inflammatory response following major trauma. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1389042

Chicago Manual of Style (16^th Edition):

McIlroy, Daniel. “The role of mitochondrial DNA in the post-injury inflammatory response following major trauma.” 2018. Doctoral Dissertation, University of Newcastle. Accessed January 22, 2021. http://hdl.handle.net/1959.13/1389042.

MLA Handbook (7^th Edition):

McIlroy, Daniel. “The role of mitochondrial DNA in the post-injury inflammatory response following major trauma.” 2018. Web. 22 Jan 2021.

Vancouver:

McIlroy D. The role of mitochondrial DNA in the post-injury inflammatory response following major trauma. [Internet] [Doctoral dissertation]. University of Newcastle; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1959.13/1389042.

Council of Science Editors:

McIlroy D. The role of mitochondrial DNA in the post-injury inflammatory response following major trauma. [Doctoral Dissertation]. University of Newcastle; 2018. Available from: http://hdl.handle.net/1959.13/1389042

University of Iowa

16. Whitmore, Laura Christine. Neutrophil priming and host inflammation: The roles of NOX2 and toll-like receptors.

Degree: PhD, Molecular and Cell Biology, 2014, University of Iowa

URL: https://ir.uiowa.edu/etd/3215

► Neutrophils, essential innate immune cells, recognize danger signals through receptors on their surface. Upon receptor ligation, neutrophils may undergo priming, a process involving limited… (more)

▼ Neutrophils, essential innate immune cells, recognize danger signals through receptors on their surface. Upon receptor ligation, neutrophils may undergo priming, a process involving limited reactive oxygen species (ROS) generation and partial degranulation. Priming facilitates neutrophil migration and prepares the cell for an enhanced response to a secondary stimulus, including a spike in ROS generation by NADPH oxidase 2 (NOX2). It is well established that NOX2-derived oxidants are involved in pathogen killing and that off-target effects can cause host tissue damage; however, several lines of recent evidence also support an anti-inflammatory function for NOX2 oxidants. First, patients with chronic granulomatous disease exhibit sterile inflammatory phenomena. Second, neutrophils lacking NOX2 function (genetically or pharmacologically) have an inflammatory phenotype under resting conditions. Finally, NOX2-deficient mice exhibit enhanced localized inflammation in several disease models. The goals of this thesis were to investigate an anti-inflammatory function for NOX2 during systemic inflammation and to further elucidate mechanisms of neutrophil priming, with particular focus on priming through Toll-like receptor 2 (TLR2). Using a murine model of sterile systemic inflammatory response syndrome (SIRS), we observed that NOX2-deficient mice had dramatically increased mortality compared to WT mice. While both genotypes developed SIRS, characterized by hypothermia, hypotension, and leukopenia, the WT mice recovered within 48 h whereas the NOX2-deficient mice did not. Moreover, NOX2 function limited the extent of pulmonary pathology as significant lung injury was noted in the NOX2-deficient mice compared to the WT mice. Plasma analysis revealed that several inflammatory cytokines were persistently elevated in the NOX2-deficient mice, likely contributing to the ongoing inflammatory response. One of the complications seen in human SIRS patients is the development of multiple organ dysfunction syndrome (MODS). Thus, we next investigated the role of NOX2 in the progression from SIRS to MODS. Cellular analysis revealed continued neutrophil recruitment to the peritoneum and lungs of the NOX2-deficient mice and altered activation states of both neutrophils and macrophages. Histology showed multiple organ pathology indicative of MODS in the NOX2-deficient mice, and several inflammatory cytokines were elevated in lungs of the NOX2-deficient mice. Overall, these data suggest that NOX2 function protects against the development of MODS and is required for normal resolution of systemic inflammation. As we utilized a TLR2/6 agonist (zymosan) to induce SIRS in our in vivo model, we wanted to investigate neutrophil priming through TLR2 in an in vitro model. Notably, we determined that a TLR2/6 agonist, FSL-1, primed neutrophils from all donors to a similar extent, evidenced by direct and primed ROS generation, MAPK signaling, limited degranulation, and cytokine secretion. Surprisingly, Pam₃CSK₄, a… Advisors/Committee Members: Moreland, Jessica G. (supervisor).

Subjects/Keywords: Inflammation; NADPH oxidase; Neutrophil; SIRS; Toll-like receptor; Cell Biology

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APA (6^th Edition):

Whitmore, L. C. (2014). Neutrophil priming and host inflammation: The roles of NOX2 and toll-like receptors. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/3215

Chicago Manual of Style (16^th Edition):

Whitmore, Laura Christine. “Neutrophil priming and host inflammation: The roles of NOX2 and toll-like receptors.” 2014. Doctoral Dissertation, University of Iowa. Accessed January 22, 2021. https://ir.uiowa.edu/etd/3215.

MLA Handbook (7^th Edition):

Whitmore, Laura Christine. “Neutrophil priming and host inflammation: The roles of NOX2 and toll-like receptors.” 2014. Web. 22 Jan 2021.

Vancouver:

Whitmore LC. Neutrophil priming and host inflammation: The roles of NOX2 and toll-like receptors. [Internet] [Doctoral dissertation]. University of Iowa; 2014. [cited 2021 Jan 22]. Available from: https://ir.uiowa.edu/etd/3215.

Council of Science Editors:

Whitmore LC. Neutrophil priming and host inflammation: The roles of NOX2 and toll-like receptors. [Doctoral Dissertation]. University of Iowa; 2014. Available from: https://ir.uiowa.edu/etd/3215

Boston University

17. Mathias, Jason. Modern approaches to sepsis - evolving definitions, clinician roles, and AI-based diagnostic aids.

Degree: MS, Medical Sciences, 2018, Boston University

URL: http://hdl.handle.net/2144/33022

► Sepsis is an ongoing concern in critical care. It is hard to quickly detect, and rapid deterioration of a patient into septic shock causes death… (more)

Subjects/Keywords: Biostatistics; Sepsis; SIRS; SOFA; Artifical intelligence; Infectious disease; Machine learning

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APA (6^th Edition):

Mathias, J. (2018). Modern approaches to sepsis - evolving definitions, clinician roles, and AI-based diagnostic aids. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/33022

Chicago Manual of Style (16^th Edition):

Mathias, Jason. “Modern approaches to sepsis - evolving definitions, clinician roles, and AI-based diagnostic aids.” 2018. Masters Thesis, Boston University. Accessed January 22, 2021. http://hdl.handle.net/2144/33022.

MLA Handbook (7^th Edition):

Mathias, Jason. “Modern approaches to sepsis - evolving definitions, clinician roles, and AI-based diagnostic aids.” 2018. Web. 22 Jan 2021.

Vancouver:

Mathias J. Modern approaches to sepsis - evolving definitions, clinician roles, and AI-based diagnostic aids. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2144/33022.

Council of Science Editors:

Mathias J. Modern approaches to sepsis - evolving definitions, clinician roles, and AI-based diagnostic aids. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/33022

Universitat Autònoma de Barcelona

18. Torrente Artero, Carlos. Aspectos diagnósticos y pronósticos de la concentración de albúmina en el paciente canino con síndrome de respuesta inflamatoria sistémica.

Degree: Departament de Medicina i Cirurgia Animals, 2014, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/284391

► Acid-base disturbances have been reported in the veterinary literature concerning the field of the small animal intensive care. Such disorders have diagnostic, therapeutic, and prognostic… (more)

▼ Acid-base disturbances have been reported in the veterinary literature concerning the field of the small animal intensive care. Such disorders have diagnostic, therapeutic, and prognostic implications in terms of morbidity and mortality in such population. Besides albumin is a weak acid that can affect pH and plays a key role in the metabolic component of the acid-base balance often is not taken into account during the acid-base assessment. The main goal of the first study was to compare the traditional and the quantitative approaches for the assessment of acid-base imbalances in hypoalbuminemic dogs. This study was designed as a prospective observational clinical study and included the evaluation of 105 critically ill patients and 135 healthy patients as controls. Jugular venous-blood samples were collected from each patient on admission to determine: TP, Alb , BUN, Glu , hematocrit, , Na+ , Cl- , K +, Pi , pH , pCO2 , HCO3 - , AG, AGalb and /or AGalb-phos, SBE, SID, Atot , and SIG. Patients were divided into two groups according to the severity of hypoalbuminemia: mild hypoalbuminemia (Alb = 2.1 to 2.5 g /dL) and severe hypoalbuminemia (Alb ≤ 2.0 g/dL). According to the HH approach most frequent imbalances were simple disorders (51.4 %) mainly metabolic acidosis (84.7%), in most cases associated to a high AG acidosis. However, when using the quantitative method 58.1% were complex disorders, and SIG acidosis (74.3 %) and Atot alkalosis (33.3 %) were the most frequent acid -base imbalances. The second study allowed us to conclude that the agreement between the traditional and quantitative methods of interpretation of acid-base balance was poor, and many imbalances were detected using the quantitative approach but would remain undetected using the traditional approach to acid-base status. Moreover, these alterations were different according to the severity of hypoalbuminemia and characteristics of the disease in each hypoalbuminemic patient, especially in SIRS/septic patients. In humans, SIRS is relatively frequent condition and is associated with high mortality rates. However, data on the incidence of SIRS and the usefulness of biomarkers in veterinary medicine is scarce. The main goal of the second study was to determine the diagnostic and prognostic value of plasma iron vs the inflammatory markers albumin, CRP and fibrinogen on admission and over the ICU stay of dogs with SIRS. This study was designed as prospective observational study and included 116 client-owned dogs: 54 dogs with SIRS/sepsis, 42 with local inflammation and 20 clinically healthy dogs as a control group. Blood samples were taken on admission in all study groups, and then on alternate days until discharge or death in both inflammation groups. On admission, dogs with SIRS had significantly lower plasma iron (65 ± 5.8 µg/dL, p=0.001) concentrations than dogs with local inflammation (89.5 ± 6.2 µg/dL, p=0.001). Plasma iron, albumin, and CRP were able to separate dogs in the SIRS/sepsis group from those presenting local inflammation with… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Ruiz de Gopegui i Fernández, Rafael (director), true (authorsendemail).

Subjects/Keywords: Ácido-base; Sirs; Hierro serico; Ciències de la Salut; 619

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APA (6^th Edition):

Torrente Artero, C. (2014). Aspectos diagnósticos y pronósticos de la concentración de albúmina en el paciente canino con síndrome de respuesta inflamatoria sistémica. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/284391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Torrente Artero, Carlos. “Aspectos diagnósticos y pronósticos de la concentración de albúmina en el paciente canino con síndrome de respuesta inflamatoria sistémica.” 2014. Thesis, Universitat Autònoma de Barcelona. Accessed January 22, 2021. http://hdl.handle.net/10803/284391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Torrente Artero, Carlos. “Aspectos diagnósticos y pronósticos de la concentración de albúmina en el paciente canino con síndrome de respuesta inflamatoria sistémica.” 2014. Web. 22 Jan 2021.

Vancouver:

Torrente Artero C. Aspectos diagnósticos y pronósticos de la concentración de albúmina en el paciente canino con síndrome de respuesta inflamatoria sistémica. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10803/284391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Torrente Artero C. Aspectos diagnósticos y pronósticos de la concentración de albúmina en el paciente canino con síndrome de respuesta inflamatoria sistémica. [Thesis]. Universitat Autònoma de Barcelona; 2014. Available from: http://hdl.handle.net/10803/284391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Corconan, Lea. Reducing False Positive Feigning Classifications on the SIRS among Criminal Defendants with a History of Trauma.

Degree: MA, Psychology, 2012, City University of New York

URL: https://academicworks.cuny.edu/cc_etds_theses/119

► Clinical research has demonstrated that individuals with a traumatic history elevate scales on the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992)… (more)

Subjects/Keywords: Malingering; SIRS; Trauma; Medicine and Health Sciences; Psychiatry and Psychology

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APA (6^th Edition):

Corconan, L. (2012). Reducing False Positive Feigning Classifications on the SIRS among Criminal Defendants with a History of Trauma. (Masters Thesis). City University of New York. Retrieved from https://academicworks.cuny.edu/cc_etds_theses/119

Chicago Manual of Style (16^th Edition):

Corconan, Lea. “Reducing False Positive Feigning Classifications on the SIRS among Criminal Defendants with a History of Trauma.” 2012. Masters Thesis, City University of New York. Accessed January 22, 2021. https://academicworks.cuny.edu/cc_etds_theses/119.

MLA Handbook (7^th Edition):

Corconan, Lea. “Reducing False Positive Feigning Classifications on the SIRS among Criminal Defendants with a History of Trauma.” 2012. Web. 22 Jan 2021.

Vancouver:

Corconan L. Reducing False Positive Feigning Classifications on the SIRS among Criminal Defendants with a History of Trauma. [Internet] [Masters thesis]. City University of New York; 2012. [cited 2021 Jan 22]. Available from: https://academicworks.cuny.edu/cc_etds_theses/119.

Council of Science Editors:

Corconan L. Reducing False Positive Feigning Classifications on the SIRS among Criminal Defendants with a History of Trauma. [Masters Thesis]. City University of New York; 2012. Available from: https://academicworks.cuny.edu/cc_etds_theses/119

20. Koutroulis, Ioannis. Η εφαρμογή της προκαλσιτονίνης στη διαγνωστική των λοιμώξεων.

Degree: 2015, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/38979

► Γενικά: Τελευταία, η χρήση της προκαλσιτονίνης (PCT) έχει καθιερωθεί ως διαγνωστικός και προγνωστικός βιοδείκτης στις λοιμώξεις των παίδων και των ενηλίκων, η χρήση της όμως… (more)

▼ Γενικά: Τελευταία, η χρήση της προκαλσιτονίνης (PCT) έχει καθιερωθεί ως διαγνωστικός και προγνωστικός βιοδείκτης στις λοιμώξεις των παίδων και των ενηλίκων, η χρήση της όμως σε παιδιά με τραύμα είναι πολύ περιορισμένη σύμφωνα με τα υπάρχοντα στοιχεία.Σκοπός: Ο σκοπός της παρούσας διατριβής είναι να μελετηθεί η προκαλσιτονίνη στον ορό του αίματος ως διαγνωστικός και προγνωστικός δείκτης σε παιδιά με τραύμα. Συγκεκριμένα ο στόχος της μελέτης είναι να διερευνηθεί εάν η προκαλσιτονίνη του ορού θα μπορούσε να χρησιμοποιηθεί ως αξιόπιστος διαγνωστικός και προγνωστικός δείκτης σε παιδιά με τραύμα και κυρίως στο διαχωρισμό μεταξύ σήψης και συνδρόμου συστηματικής φλεγμονώδους αντίδρασης(SIRS) στα παιδιά με τραύμα και να συγκριθεί με άλλους ευρέως χρησιμοποιούμενους βιοδείκτες όπως η CRP.Μέθοδοι: Αρχικά, έγινε εμπεριστατωμένη ανασκόπηση της βιβλιογραφίας, χρησιμοποιώντας τη βάση δεδομένων Pubmed. Επικεντρωθήκαμε στη χρήση μετα-ανάλυσης από πληθυσμούς ενηλίκων, εξετάζοντας την ερμηνεία και τη μεθοδολογία κάθε έρευνας και όπου ήταν δυνατόν,βρήκαμε αντίστοιχες παιδιατρικές μελέτες για να καθοριστεί εάν τα ίδια αποτελέσματα ισχύουν και στον παιδικό πληθυσμό. Οι πιο σημαντικές ερευνητικές εργασίες αναλύθηκαν διεξοδικά.Στη μελέτη περιλήφθησαν παιδιά ηλικίας 0-18 ετών που μεταφέρθηκαν στο Τμήμα Επειγόντων Περιστατικών του SCHC (Pensylvannia, PA, USA) και για τα οποία έγινε μερική ή πλήρης ενεργοποίηση της ομάδας τραύματος και άμεση εισαγωγή στη Μονάδα Εντατικής Θεραπείας Παίδων (ΜΕΘ). Οι μετρήσεις PCT έγιναν στους ασθενείς στις ώρες 0, 6, 12, 24 από την εισαγωγή στο νοσοκομείο και στη συνέχεια καθημερινά μέχρι την οριστική έξοδο από την ΜΕΘ ή το θάνατο.Οι ασθενείς με τραύμα ανάλογα με την κλινική διάγνωση χωρίστηκαν σε τρεις ομάδες: α) παιδιά με τραύμα και σήψη, β) παιδιά με τραύμα και σύνδρομο συστηματικής φλεγμονώδους αντίδρασης (SIRS) και γ) παιδιά με τραύμα άνευ σήψης ή SIRS.Αποτελέσματα: Στην παρούσα μελέτη περιελήφθησαν 90 παιδιά με τραύμα με εύρος ηλικίας από 13 μήνες μέχρι 18 έτη και μέση ηλικία τα 7 έτη. Οι περισσότεροι εκ των ασθενών ήταν άρρενες σε ποσοστό 62% (n=52). Τα αμβλέα τραύματα (86 %) κυριάρχησαν στους ασθενείς της μελέτης κυρίως από τροχαία ατυχήματα. Ο μέσος όρος στην κλίμακα σοβαρότητας των τραυματισμών (ISS) ήταν 18, ενώ η θνησιμότητα έφτασε το 11%. Ποσοστό 33% (n=29) των ασθενών πληρούσε τα κριτήρια για διάγνωση σήψης και 22% (n=20) τα κριτήρια για διάγνωση SIRS. Ο μέσος χρόνος παραμονής στη ΜΕΘ ήταν 8 ημέρες και η αναπνευστική υποστήριξη κατά μέσο όρο για 5 ημέρες. Οι κύριες λοιμώξεις που διαγνώστηκαν ήταν πνευμονία, λοιμώξεις του ουροποιητικού συστήματος και βακτηριαιμία.Σημειώθηκε παροδική αύξηση των επιπέδων PCT σε όλες τις ομάδες κατά τη διάρκεια των πρώτων 24 με 48 ωρών μετά την εισαγωγή στο νοσοκομείο. Μια δεύτερη κορυφή με ακόμα υψηλότερα επίπεδα PCΤ, παρατηρήθηκε σε ασθενείς με τραύμα και σήψη μεταξύ των ημερών 6 και 9. Αυξημένα PCT επίπεδα μετά τις πρώτες 48 ώρες δεν παρατηρήθηκαν στην ομάδα με τραύμα και SIRS αλλά ούτε στην ομάδα με ασθενείς με τραύμα και άνευ σήψης ή SIRS. Η μέση τιμή PCT ήταν…

Subjects/Keywords: Προκαλσιτονίνη; Τραύμα; Παιδιά; Σήψη; Λοιμώξεις; Procalcitonin; Sepsis; SIRS; Trauma; Children

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koutroulis, I. (2015). Η εφαρμογή της προκαλσιτονίνης στη διαγνωστική των λοιμώξεων. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/38979

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koutroulis, Ioannis. “Η εφαρμογή της προκαλσιτονίνης στη διαγνωστική των λοιμώξεων.” 2015. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 22, 2021. http://hdl.handle.net/10442/hedi/38979.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koutroulis, Ioannis. “Η εφαρμογή της προκαλσιτονίνης στη διαγνωστική των λοιμώξεων.” 2015. Web. 22 Jan 2021.

Vancouver:

Koutroulis I. Η εφαρμογή της προκαλσιτονίνης στη διαγνωστική των λοιμώξεων. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10442/hedi/38979.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koutroulis I. Η εφαρμογή της προκαλσιτονίνης στη διαγνωστική των λοιμώξεων. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. Available from: http://hdl.handle.net/10442/hedi/38979

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Antonopoulos, Nikolaos. Μελέτη της απόπτωσης υποπληθυσμών λευκοκυττάρων σε καρδιοχειρουργικούς ασθενείς.

Degree: 2014, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/41317

► Background: Cardiac surgery under cardiopulmonary bypass (CPB) induces a major postoperative systemic inflammatory response (SIRS) causing variations on apoptotic potential of leukocyte subpopulations. The purpose… (more)

▼ Background: Cardiac surgery under cardiopulmonary bypass (CPB) induces a major postoperative systemic inflammatory response (SIRS) causing variations on apoptotic potential of leukocyte subpopulations. The purpose of this study is the qualitative and quantitative study of apoptosis in six leukocyte subpopulations [T (CD3+/CD4+) / T (CD3+/CD8+) / Β (CD19+) / NK (CD16+/56+) / CD14+ monocytes and CD16+ granulocytes], the study of expression of seven pro- and anti-apoptotic genes (BCLA2A1, BCL2L1, MCL1, BAX, BID, XIAP και BIRC3), the correlation of apoptosis with the levels of pro- and anti-inflammatory cytokines (IL-1b, Il-6, IL-7, IL-8, IL-10, sFasL και TNFa) and its prognostic value for the postoperative development of cardiac patients.Methods: We studied 56 patients undergoing various cardiac surgery procedures with cardiopulmonary bypass (CPB). Apoptotic cells were double stained with Annexin V and propidium iodide and then analyzed by flow cytometry method. Expression of pro- and anti-apoptotic genes was studied with microarrays’ analysis and use of quantitative RT-PCR. Serum cytokine levels were measured using Luminex-xMap method. Blood sampling carried out at the point of induction of anaesthesia (T0), immediately after surgery (T1), 6 h (T2), 24 h (T3) and 48 h postoperatively (T4).Results: Apoptosis in leukocyte subpopulations, except in the case of B-(CD19+) lymphocytes, inhibited immediately after surgery (T1) (p < 0.001) showing an increase at 24 hours postoperatively (T3) (p < 0.001) and a stabilization at 48 hours postoperatively (T4) (p < 0.001). Percentage of neutrophil apoptosis correlated negatively (Spearman’s ratio : -0,450) with its absolute number immediately after surgery (T1). Additionaly, there was a negative significant correlation between the percentage of neutrophil apoptosis at induction of anaesthesia (T0) and development of postoperative atrial fibrillation (Spearman’s ratio: - 0,469) in coronary patients. Expression of antiapoptotic gene BCL2A1 significantly increased immediately postoperatively (T1) in granulocytes and peripheral blood mononuclear cells (p = 0.008 and 0.021 respectively). Concentrations of inflammatory cytokines IL-6 and IL-8 showed their peak value immediately postoperatively (T1) (p < 0.001), followed by a gradual postoperative decrease 24 h (T3) (p < 0.001) and 48h postoperatively (T4) (p < 0.001 and p = 0.022 respectively). Concentration of IL-10 showed its peak value 6 h postoperatively (T2) (p < 0.001), followed by a gradual postoperative decrease 24 h (T3) (p < 0.001) and 48h postoperatively (T4) (p < 0.001).Conclusions: Inhibition of apoptosis immediately after surgery (T1) was observed in the majority of leukocyte subpopulations, followed by gradual increase 24 h (T3) and 48 h (T4) postoperatively in values similar of those at the point of induction of anaesthesia. Preoperative percentage of neutrophil apoptosis could be a biomarker predicting the susceptibility of patient for the development of postoperative atrial fibrillation (POAF). Inhibition of…

Subjects/Keywords: Καρδιοχειρουργική; Aπόπτωση λευκοκυτταρικών υποπληθυσμών; Σύνδρομο συστηματικής φλεγμονώδους αντίδρασης (SIRS); Εξωσωματική κυκλοφορία; Κυτοκίνες; Cardiac surgery; Leukocyte subpopulation apoptosis; Systemic inflammatory response syndrome (SIRS); Cardiopulmonary bypass; Cytokines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Antonopoulos, N. (2014). Μελέτη της απόπτωσης υποπληθυσμών λευκοκυττάρων σε καρδιοχειρουργικούς ασθενείς. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/41317

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Antonopoulos, Nikolaos. “Μελέτη της απόπτωσης υποπληθυσμών λευκοκυττάρων σε καρδιοχειρουργικούς ασθενείς.” 2014. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 22, 2021. http://hdl.handle.net/10442/hedi/41317.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Antonopoulos, Nikolaos. “Μελέτη της απόπτωσης υποπληθυσμών λευκοκυττάρων σε καρδιοχειρουργικούς ασθενείς.” 2014. Web. 22 Jan 2021.

Vancouver:

Antonopoulos N. Μελέτη της απόπτωσης υποπληθυσμών λευκοκυττάρων σε καρδιοχειρουργικούς ασθενείς. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10442/hedi/41317.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Antonopoulos N. Μελέτη της απόπτωσης υποπληθυσμών λευκοκυττάρων σε καρδιοχειρουργικούς ασθενείς. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2014. Available from: http://hdl.handle.net/10442/hedi/41317

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

22. Schadenberg, A.W.L. Immune regulation following pediatric cardiac surgery - What goes up must come down.

Degree: 2013, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/287634

► The immune system is a dynamic system that is designed to respond rapidly to potential harmful stimuli. Following activation tight control mechanisms are in place… (more)

▼ The immune system is a dynamic system that is designed to respond rapidly to potential harmful stimuli. Following activation tight control mechanisms are in place to avoid collateral damage. Cardiac surgery is well known to induce an acute systemic inflammatory response and therefore, elective cardiac surgery creates an opportunity to study the inflammatory response in human in detail, from its initiation through the peak of inflammation up to recovery. So to restore the dynamic immunological equilibrium; ‘What goes up must come down’. In this thesis we illustrate how the immune system of children responds to two different aspects of pediatric cardiac surgery, both known to disturb the immunological equilibrium. In the first part of this thesis the immediate inflammatory response due to surgery is investigated with an emphasis on endogenous feedback mechanisms. In the second part of this thesis we investigate how the developing immune system copes with total thymectomy due to neonatal cardiac surgery. We describe two intrinsic regulatory mechanisms detectable immediately after the onset of the systemic inflammatory response due to pediatric cardiac surgery. First, monocytes exhibit a reduced responsiveness to toll like receptor stimulation. This reduced responsiveness is due to active regulation maintained predominantly through the IL-10/STAT3 pathway. Secondly, the regulatory transcription factor FOXP3 is upregulated in T cells. These FOXP3+ T cells remain unresponsive to TCR stimulation, like true FOXP3+ regulatory T cells (Treg), though show a reduced capacity to inhibit effector T cells. A reduced regulatory capacity of healthy Treg can be induced through exposure to plasma taken from patients after cardiac surgery. This implies a plasma mediated regulation of Treg during the peak of a systemic inflammatory response after pediatric cardiac surgery. Neonatal cardiac surgery often necessitates removal of the complete thymus to gain access to the surgical site. We studied the short and long term effects of neonatal thymectomy. In the first years after neonatal thymectomy, the immune system is unable to maintain naive T cell numbers. From approximately 5 years onwards we found evidence of renewed thymic activity. Although naive T cells subsequently return to normal healthy numbers, the effect of neonatal thymectomy on functionality of the T cell compartment requires further studies. The FOXP3+ Treg population is crucial for immune homeostasis in most inflammatory conditions. Peripheral proliferation of Treg cells counteracts the effect of loss of thymopoiesis, which illustrates the relative plasticity of the human immune system. However, changes in composition of the Treg population do warrant further investigation in the long-term functional effects of neonatal thymectomy following cardiac surgery. Advisors/Committee Members: Prakken, A.B.J., Jansen, N.J.G..

Subjects/Keywords: Geneeskunde; pediatric cardiac surgery; inflammation; regulation; Treg; SIRS; T-cell; monocyte; thymectomy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schadenberg, A. W. L. (2013). Immune regulation following pediatric cardiac surgery - What goes up must come down. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/287634

Chicago Manual of Style (16^th Edition):

Schadenberg, A W L. “Immune regulation following pediatric cardiac surgery - What goes up must come down.” 2013. Doctoral Dissertation, Universiteit Utrecht. Accessed January 22, 2021. http://dspace.library.uu.nl:8080/handle/1874/287634.

MLA Handbook (7^th Edition):

Schadenberg, A W L. “Immune regulation following pediatric cardiac surgery - What goes up must come down.” 2013. Web. 22 Jan 2021.

Vancouver:

Schadenberg AWL. Immune regulation following pediatric cardiac surgery - What goes up must come down. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2013. [cited 2021 Jan 22]. Available from: http://dspace.library.uu.nl:8080/handle/1874/287634.

Council of Science Editors:

Schadenberg AWL. Immune regulation following pediatric cardiac surgery - What goes up must come down. [Doctoral Dissertation]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/287634

23. Μπαξεβάνος, Νικόλαος. Πειραματικό μοντέλο πολυτραυματία: ανοσοπαρεμβατική θεραπεία με νεώτερους αντιοξειδωτικούς παράγοντες.

Degree: 2013, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/37338

►

Severe trauma patients are in increased risk of multiple organ failure as aresult of excessive inflammatory response aggravating bacterial translocation.An experimental model of severe trauma… (more)

▼

Severe trauma patients are in increased risk of multiple organ failure as aresult of excessive inflammatory response aggravating bacterial translocation.An experimental model of severe trauma was utilized to define the impact ofbacterial translocation on survival and on inflammatory response. In thepresent study forty-one rabbits were divided into two groups: A, femurmyotomy alone (sham); and B, femur facture (injury). Vital signs and survivalwere recorded. Serum circulating endotoxins (LPS) were determined andtissue cultures were performed at autopsy. A subgroup of animals wassacrificed at 48 h post injury: LPS was determined in abdominal aorta andportal vein, apoptosis rate of spleen cells was assessed by flow cytometry,and ex vivo production of tumor necrosis factor-alpha (TNF-α) by spleen cellswas measured. Tissue bacterial burden was increased in animals that diedearly i.e. within 48 hours after injury than in rabbits that died later. Portal veinLPS at 48 hours was increased in injury rabbits compared to animalssubjected to femur myotomy, whereas circulating LPS disclosed nodifference. No difference on apoptosis rate of either macrophage-bearing orlymphocyte-bearing spleen cells was detected in injury animals compared tofemur myotomy ones. Following stimulation with LPS or phytohaemagglutinin(PHA), TNFα production by spleen cells of injury animals was higher than thatby sham animals. Thus, it is concluded that bacterial translocation inducespro-inflammatory responses and is associated with early death in severetrauma.

Οι σοβαρά τραυματισμένοι ασθενείς αντιμετωπίζουν αυξημένο κίνδυνο για τηνανάπτυξη οργανικής ανεπάρκειας ως αποτέλεσμα μιας υπέρμετρηςφλεγμονώδους ανταπόκρισης που μπορεί να επιβαρυνθεί από τη βακτηριακήαλλόθεση. Ένα πειραματικό πρότυπο τραύματος σε κονίκλουςχρησιμοποιήθηκε για τη διερεύνηση της επίδρασης της βακτηριακήςαλλόθεσης στην επιβίωση και στη φλεγμονώδη ανταπόκριση. Στην παρούσαεργασία σαράντα ένας κόνικλες διαχωρίστηκαν σε δύο ομάδες: Α. κόνικλοιστους οποίους έγινε μόνο διατομή του έξω πλατέος μηριαίου μυ (εικονικόχειρουργείο) και Β, κόνικλοι στους οποίους προκλήθηκε κάταγμα στο μηριαίοοστό (τραυματισμός). Έγινε καταγραφή των ζωτικών σημείων και τηςεπιβίωσης, μετρήθηκαν οι κυκλοφορούσες στον ορό ενδοτοξίνες (LPS) καιδιενεργήθηκαν κυτταρικές καλλιέργειες μετά από νεκροτομή. Μια υποομάδαζωικών προτύπων θυσιάστηκε 48 ώρες μετά τον τραυματισμό: μετρήθηκαν οιτιμές LPS από δείγματα που λήφθηκαν από την κοιλιακή αορτή και τηνπυλαία φλέβα, ο ρυθμός απόπτωσης των σπληνικών κυττάρων μεκυταρρομετρία ροής και επίσης υπολογίστηκε η ex vivo παραγωγή τουπαράγοντα νέκρωσης α (TNF-α) σε κύτταρα που προέρχονταν από τοσπλήνα. Το βακτηριακό φορτίο ήταν αυξημένο στα ζωικά πρότυπα πουαπεβίωσαν ταχέως, δηλαδή μέσα στις πρώτες 48 ώρες μετά τον τραυματισμόσε σχέση με τα πειραματικά πρότυπα που απεβίωσαν όψιμα. Οι τιμές LPSαπό την πυλαία φλέβα ήταν αυξημένες στις 48 ώρες στους κονίκλους πουυπέστησαν κάταγμα συγκριτικά με τους κονίκλους που υποβλήθηκαν σεεικονικό χειρουργείο. Δεν ανιχνεύθηκε διαφορά στο ποσοστό…

Subjects/Keywords: Πολυτραυματίας; Σύνδρομο συστηματικής φλεγμονώδους αντίδρασης; Πολυοργανική δυσλειτουργία; Βακτηριακή αλλόθεση; Multiple trauma; SIRS; MODS; Bacterial translocation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Μπαξεβάνος, . �. (2013). Πειραματικό μοντέλο πολυτραυματία: ανοσοπαρεμβατική θεραπεία με νεώτερους αντιοξειδωτικούς παράγοντες. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/37338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Μπαξεβάνος, Νικόλαος. “Πειραματικό μοντέλο πολυτραυματία: ανοσοπαρεμβατική θεραπεία με νεώτερους αντιοξειδωτικούς παράγοντες.” 2013. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 22, 2021. http://hdl.handle.net/10442/hedi/37338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Μπαξεβάνος, Νικόλαος. “Πειραματικό μοντέλο πολυτραυματία: ανοσοπαρεμβατική θεραπεία με νεώτερους αντιοξειδωτικούς παράγοντες.” 2013. Web. 22 Jan 2021.

Vancouver:

Μπαξεβάνος �. Πειραματικό μοντέλο πολυτραυματία: ανοσοπαρεμβατική θεραπεία με νεώτερους αντιοξειδωτικούς παράγοντες. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10442/hedi/37338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Μπαξεβάνος �. Πειραματικό μοντέλο πολυτραυματία: ανοσοπαρεμβατική θεραπεία με νεώτερους αντιοξειδωτικούς παράγοντες. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. Available from: http://hdl.handle.net/10442/hedi/37338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Mitchell, Evan. Network structures and their effect on a stochastic SIRS model of epilepsy EEG data.

Degree: MSc, 2017, McMaster University

URL: http://hdl.handle.net/11375/22173

►

In this thesis, we consider a stochastic SIRS model of EEG data. The model is built over three different network structures: a random network, a… (more)

Subjects/Keywords: mathematical model; SIRS; epilepsy; EEG

…List of Abbreviations EEG → electroencephalogram SIRS → susceptible-infected-recovered… …stages and the stages of the typical SIRS epidemiological model: as an action potential (… …to address a couple of questions. First: Can the stochastic SIRS model built over certain… …time series characteristics of a SIRS system. 2 2.1 Methods Collecting and preparing the… …Thesis - E. Mitchell 2.3 McMaster University - Mathematics The stochastic SIRS model and…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mitchell, E. (2017). Network structures and their effect on a stochastic SIRS model of epilepsy EEG data. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/22173

Chicago Manual of Style (16^th Edition):

Mitchell, Evan. “Network structures and their effect on a stochastic SIRS model of epilepsy EEG data.” 2017. Masters Thesis, McMaster University. Accessed January 22, 2021. http://hdl.handle.net/11375/22173.

MLA Handbook (7^th Edition):

Mitchell, Evan. “Network structures and their effect on a stochastic SIRS model of epilepsy EEG data.” 2017. Web. 22 Jan 2021.

Vancouver:

Mitchell E. Network structures and their effect on a stochastic SIRS model of epilepsy EEG data. [Internet] [Masters thesis]. McMaster University; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11375/22173.

Council of Science Editors:

Mitchell E. Network structures and their effect on a stochastic SIRS model of epilepsy EEG data. [Masters Thesis]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/22173

Univerzitet u Beogradu

25. Milić, Ljiljana, 1969-. Prognostički značaj proteina HMGB1 u difuznom sekundarnom peritonitisu.

Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:13291/bdef:Content/get

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Medicina / Medicine

Sekundarni peritonitis je hirurško stanje koje iziskuje neodložno operativno lečenje. Često je praćen sepsom sa relativno visokom incidencom i stopom smrtnosti. Intraabdominalna… (more)

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Medicina / Medicine

Sekundarni peritonitis je hirurško stanje koje iziskuje neodložno operativno lečenje. Često je praćen sepsom sa relativno visokom incidencom i stopom smrtnosti. Intraabdominalna infekcija kao izvor sepse aktivira zapaljenje tokom kog brojni medijatori određuju patogenetski tok i ishod sekundarnog peritonitisa. U ovoj doktorskoj disertaciji smo istraživali povezanost nivoa HMGB1 (engl. high mobility group box 1) proteina preoperativno i postoperativno do otpusta iz bolnice, kao i akutne markere inflamacije: serum amiloid A (SAA) i češće ispitivane markere, kao što su C-reaktivni protein (CRP) i prokalcitonin (PCT), sa razvojem sindroma sistemskog inflamatornog odgovora (SIRS) i sepse kod pacijenata sa sekundarnim peritonitisom. Uticaj operativnog lečenja na kinetiku ovih markera je poređen sa nivoima kod pacijenata sa preponskim kilama bez znakova inflamacije. Nađene su značajno više preoperativne vrednosti svih ispitivanih markera u grupi sa peritonitisom u odnosu na pacijente sa kilama. U grupi sa peritonitisom, preoperativne vrednosti i vremenski obrazac promene HMGB1 su se značajno visoko razlikovale u grupi pacijenata koji su razvili sepsu, u odnosu na grupu kod koje SIRS nije bio praćen infekcijom. Kod septičnih pacijenata, vrednosti HMGB1 su blago opadale prvih dana posle operacije, dosežući najnižu tačku trećeg dana praćenja. Potom su rasle do sedmog postoperativnog dana, da bi nakon toga vrednosti opadale. Sa druge strane, u grupi SIRS, najniže vrednosti se registruju već prvog postoperativnog dana praćenja, da bi potom postepeno porasle, sa maksimumom u trećem postoperativnom danu i oscilirale između te dve vrednosti do kraja perioda praćenja. Preoperativne vrednosti SAA se nisu razlikovale kod septičnih pacijenata i pacijenata sa SIRS-om, ali se obrazac promene SAA postoperativno značajno razlikovao među ovim grupama. Kod septičnih pacijenata su vrednosti vrlo značajno porasle nakon prvog postoperativnog dana, a zatim kontinuirano opadale do kraja perioda hospitalizacije. Nasuprot tome, kod pacijenata sa SIRS-om, vrednosti su opadale u odnosu na preoperativnu vrednost, što je bilo visoko značajno različito, u odnosu na grupu septičnih pacijenata. Preoperativne vrednosti CRP-a i PCT-a su bile značajno više u grupi septičnih pacijenata u odnosu na grupu sa SIRS-om. Vrednosti CRP-a dostižu maksimalne vrednosti drugog postopertivnog dana, a PCT-a prvog postoperativnog dana...

Advisors/Committee Members: Peško, Predrag, 1955-.

Subjects/Keywords: secondary peritonitis; HMGB1; C-reactive protein; procalcitonin; serum amyloid A; markers of inflammation; sepsis; SIRS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Milić, Ljiljana, 1. (2016). Prognostički značaj proteina HMGB1 u difuznom sekundarnom peritonitisu. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:13291/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Milić, Ljiljana, 1969-. “Prognostički značaj proteina HMGB1 u difuznom sekundarnom peritonitisu.” 2016. Thesis, Univerzitet u Beogradu. Accessed January 22, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:13291/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Milić, Ljiljana, 1969-. “Prognostički značaj proteina HMGB1 u difuznom sekundarnom peritonitisu.” 2016. Web. 22 Jan 2021.

Vancouver:

Milić, Ljiljana 1. Prognostički značaj proteina HMGB1 u difuznom sekundarnom peritonitisu. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Jan 22]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:13291/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Milić, Ljiljana 1. Prognostički značaj proteina HMGB1 u difuznom sekundarnom peritonitisu. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:13291/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

26. Hamad, Abdul Aziz (author). Modelling epidemic spreading phenomena processes on networks.

Degree: 2018, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:0a29e4da-649a-4919-9c13-00da4aa061ef

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Spreading processes are ubiquitous in nature and societies, e.g. spreading of diseases and computer virus, propagation of messages, and activation of neurons. Computer viruses cause… (more)

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Spreading processes are ubiquitous in nature and societies, e.g. spreading of diseases and computer virus, propagation of messages, and activation of neurons. Computer viruses cause an enormous economic loss. Moreover, many illnesses/diseases still causing a serious threat to public health. For example, the outbreaks of circulating influenza strains cause millions of illness and deaths worldwide every year. Pronounced outbreaks of flu usually occur during winter. This recognized timing allows public health agencies to organize their flu-related mitigation and response activities to prepare for the winter flu season. Although the general wintertime peak of influenza incidence in temperate regions can be easily forecast, the specific intensity, duration, and time of individual local outbreaks are quite changeable. Even after an outbreak has begun, it is still difficult to predict the future characteristics of the epidemic curve. If the diseases/viruses outbreak characteristics could be reliably predicted, the public health response will be better coordinated.The goal is to develop a fast and accurate epidemic model to estimate, fit and forecast the spreading of an epidemic on a defined network. The aim is to conduct a study over viruses spreading phenomena both theoretically and numerically, then create a general model/algorithm that can be easily applied to different diseases and computer viruses. In this master thesis, we propose a new approach which can be used on real illness/viruses data (such as influenza) to estimate and forecast the epidemic more accurately. The approach is to use a model-inference system combining the network science, susceptible-infected-recovered-susceptible (SIRS) model, statistical filtering techniques and gradient descent. We are able to fit and estimate with a relatively low error compared to other algorithms. Moreover, we forecast the out-breaker with a high accuracy, four weeks before the true out-breaker on synthetic epidemic data. The model is evaluated on a regular graph, Erdös-Rényi graph, Watts-Strogatz small-world graph, & Barabási-Albert graph. Furthermore, the model is carried out on real-world epidemic data (influenza data) for four countries (the Netherlands, Germany, Belgium and the United Kingdom), from the years 2012 to 2017.

Electrical Engineer | Telecommunications and sensing systems

Advisors/Committee Members: Van Mieghem, Piet (mentor), Liu, Qiang (mentor), Ma, Long (mentor), Delft University of Technology (degree granting institution).

Subjects/Keywords: Epidemic; SIRS; Ensemble Kalman filter; Gradient descent; Real-world epidemic data (influenza data)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamad, A. A. (. (2018). Modelling epidemic spreading phenomena processes on networks. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:0a29e4da-649a-4919-9c13-00da4aa061ef

Chicago Manual of Style (16^th Edition):

Hamad, Abdul Aziz (author). “Modelling epidemic spreading phenomena processes on networks.” 2018. Masters Thesis, Delft University of Technology. Accessed January 22, 2021. http://resolver.tudelft.nl/uuid:0a29e4da-649a-4919-9c13-00da4aa061ef.

MLA Handbook (7^th Edition):

Hamad, Abdul Aziz (author). “Modelling epidemic spreading phenomena processes on networks.” 2018. Web. 22 Jan 2021.

Vancouver:

Hamad AA(. Modelling epidemic spreading phenomena processes on networks. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Jan 22]. Available from: http://resolver.tudelft.nl/uuid:0a29e4da-649a-4919-9c13-00da4aa061ef.

Council of Science Editors:

Hamad AA(. Modelling epidemic spreading phenomena processes on networks. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:0a29e4da-649a-4919-9c13-00da4aa061ef

Freie Universität Berlin

27. Jäger, Tom Philipp. Quantification and detailed characterization of low-density granulocytes in systemic vasculitides and inflammations.

Degree: 2020, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-27442

► Neutrophil granulocytes (PMNs) are an essential in innate immunity, they act primarily proinflammatory. Granulocytes are not homogeneous in functions and characteristics, therefore the term "neutrophilic… (more)

▼ Neutrophil granulocytes (PMNs) are an essential in innate immunity, they act primarily proinflammatory. Granulocytes are not homogeneous in functions and characteristics, therefore the term "neutrophilic heterogeneity" has been created. There is a distinct subpopulation of low-density granulocytes (LDGs). LDGs were isolated in autoimmune diseases and sepsis, they have been attributed both pro- and anti-inflammatory characteristics. In systemic lupus erythematosus (SLE), the proportion of LDG correlates with disease activity and the prevalence of vasculitis. In sepsis associations between LDGs and disease severity were found. The aim of this work is to analyse the relationships between LDGs and systemic vasculitis as well as between LDGs and systemic inflammations. The exact characterization and quantification of LDGs should also provide information on the unclear origin of LDGs. Whole blood samples of test persons with systemic vasculitis and systemic inflammation were taken and compared with those from healthy controls. Density gradient centrifugation has been used to separate PMNs from PBMCs, which contain LDGs. Both were stained with fluorescently labelled antibodies against surface antigens of CD14, CD16, CD86, CD66b, CD177 and HLA-DR. Then the receptor expression was measured by flow cytometry. The resulting data were statistically analysed. We found increased LDG levels in patients with systemic vasculitis and inflammation. Compared to PMNs, LDGs generally show increased expressions of CD14, CD16 and HLA-DR. The presence of systemic vasculitis and inflammation results in decreased expressions of CD16. The incidence of CD14-positive LDGs in systemic vasculitis is increased. In systemic inflammations, a negative correlation between LDG level and CRP, disease activity, and mortality was found. In vitro stimulation of whole blood from healthy individuals caused increased LDG levels. Increased LDG levels are a characteristic of systemic vasculitis and inflammation, so it could indicate increased immune activity. High LDG levels in systemic inflammations represent a more favourable prognosis regarding disease severity and mortality, therefore the LDG level could be a potential prognostic marker. The increased expression of CD14, CD16 and HLA-DR appears to be an inherent feature of LDGs over PMNs, 12 occurring independently in all test groups. In this regard, LDGs have similarities to monocytes. In systemic inflammations and vasculitis, lower expression of CD16 were shown on LDGs, which may be considered an indication of immunosuppressive functions. In vitro stimulation of whole blood can provoke higher LDG levels. This indicates that LDGs are not progenitor cells but mature, possibly degranulated granulocytes. Advisors/Committee Members: male (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: LDG; low density granulocytes; systemic vasculitides; ANCA; SIRS; Sepsis; vasculitis; systemic inflammation; ddc:610

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jäger, T. P. (2020). Quantification and detailed characterization of low-density granulocytes in systemic vasculitides and inflammations. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-27442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jäger, Tom Philipp. “Quantification and detailed characterization of low-density granulocytes in systemic vasculitides and inflammations.” 2020. Thesis, Freie Universität Berlin. Accessed January 22, 2021. http://dx.doi.org/10.17169/refubium-27442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jäger, Tom Philipp. “Quantification and detailed characterization of low-density granulocytes in systemic vasculitides and inflammations.” 2020. Web. 22 Jan 2021.

Vancouver:

Jäger TP. Quantification and detailed characterization of low-density granulocytes in systemic vasculitides and inflammations. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Jan 22]. Available from: http://dx.doi.org/10.17169/refubium-27442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jäger TP. Quantification and detailed characterization of low-density granulocytes in systemic vasculitides and inflammations. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-27442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Technical University of Lisbon

28. Prata, Sara Azevedo. Modelo canino para sépsis : contribuição para a classificação e estratificação em doentes sépticos.

Degree: 2017, Technical University of Lisbon

URL: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14334

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Dissertação de Mestrado Integrado em Medicina Veterinária

A sépsis é uma síndrome grave que pode surgir por diversos motivos, afetando muitos seres Humanos e animais.… (more)

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Dissertação de Mestrado Integrado em Medicina Veterinária

A sépsis é uma síndrome grave que pode surgir por diversos motivos, afetando muitos seres Humanos e animais. Devido à sua elevada prevalência e às elevadas taxas de mortalidade que lhe podem estar associadas, é importantíssimo o seu estudo. A Parvovirose canina predispõe à ocorrência de sépsis secundária a translocação bacteriana de origem gastrointestinal. Estudos com animais naturalmente infetados por Parvovírus podem ser úteis no estudo da sépsis, não só em animais, mas também em seres humanos. O principal objetivo do estudo foi propor e aplicar um sistema de classificação de pacientes sépticos baseado no modelo PIRO (Predisposition, Insult, Response, Organ failure). Em paralelo, foram estudadas as diferenças entre dois métodos de avaliação de SRIS (Síndrome de Resposta Inflamatória Sistémica). Foram avaliados alguns mediadores inflamatórios e a presença de DNA bacteriano no sangue de animais com Parvovirose. Os 31 animais da amostra foram classificados segundo o sistema proposto no que toca à Predisposição, Resposta, e Disfunção orgânica (para o elemento Infeção foi atribuída a todos a mesma classificação). Os dados foram recolhidos a partir de registos clínicos obtidos na UIDI do HEV-FMV-UL e sujeitos a dois conjuntos de critérios para diagnóstico de SRIS. Em 13 animais foi quantificada a concentração de CRP, e em 12 animais a expressão de mRNA de IL-6 e TNF-α, em relação a animais controlo. Foi investigada a presença de DNA bacteriano de E. coli e de Staphylococcus spp. no sangue de 12 animais. As concentrações de CRP medidas no sangue de cães com Parvovirose foram mais elevadas em relação às medidas no sangue de cães do grupo controlo (p<0.001), tendo sido determinado um valor de concentração de CRP (83,8 mg/L) a partir do qual é possível dizer que está em curso um processo de SRIS (AUC=0.85). As diferenças entre a utilização de diferentes conjuntos de critérios de diagnóstico de SRIS, tanto à entrada como às 48h após internamento, revelaram-se significativas (p<0,01). Não houve diferenças entre as classificações PIRO no início do internamento e após 48h (p=0,187). Não foi verificada uma correlação entre o aumento da concentração sérica de CRP e o aumento da classificação PIRO (rs=0,187; p=0,540). Foi detetada expressão de IL-6 e TNF-α em, respetivamente, 5 e 6 animais com Parvovirose, apesar de não ter sido possível o estudo das medições de IL-6 e TNF-α. Foi detetado DNA bacteriano em 3 dos cães com Parvovirose. Este trabalho representa uma contribuição para o desenvolvimento de um sistema de classificação de doentes sépticos da espécie canina. Foi possível estabelecer um valor de uma proteína de fase aguda (CRP) a partir do qual podemos afirmar que ocorre SRIS. É premente descobrir outros biomarcadores capazes de monitorizar mais objetivamente pacientes Humanos e animais e permitir uma intervenção mais precoce no decurso do agravamento clínico.

ABSTRACT - Canine model for sepsis: a contribution to the classification and stratification of septic…

Advisors/Committee Members: Gil, Solange Judite Roque Coelho Alves, Silva, Frederico Nuno Castanheira Aires da.

Subjects/Keywords: Parvovirose; sépsis; SRIS; PIRO; CRP; IL-6; TNF-α; bDNA; Hospital escolar veterinário; CPV; Parvovirus; SIRS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Prata, S. A. (2017). Modelo canino para sépsis : contribuição para a classificação e estratificação em doentes sépticos. (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Prata, Sara Azevedo. “Modelo canino para sépsis : contribuição para a classificação e estratificação em doentes sépticos.” 2017. Thesis, Technical University of Lisbon. Accessed January 22, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Prata, Sara Azevedo. “Modelo canino para sépsis : contribuição para a classificação e estratificação em doentes sépticos.” 2017. Web. 22 Jan 2021.

Vancouver:

Prata SA. Modelo canino para sépsis : contribuição para a classificação e estratificação em doentes sépticos. [Internet] [Thesis]. Technical University of Lisbon; 2017. [cited 2021 Jan 22]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prata SA. Modelo canino para sépsis : contribuição para a classificação e estratificação em doentes sépticos. [Thesis]. Technical University of Lisbon; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

29. Kapitanov, Eszter. Egyszerű járványterjedési modelleket bemutató szoftver fejlesztése .

Degree: DE – Informatikai Kar, University of Debrecen

URL: http://hdl.handle.net/2437/201806

► A dolgozatban ismertetem az SI, SIR, SIS és SIRS járványterjedési modelleket és ismertetem ezek egyéb alkalmazási területeit. Ezek például a vélemény és innováció terjedése szociális… (more)

Subjects/Keywords: járvány; terjedés; modell; si; sir; sis; sirs; java

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APA (6^th Edition):

Kapitanov, E. (n.d.). Egyszerű járványterjedési modelleket bemutató szoftver fejlesztése . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/201806

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kapitanov, Eszter. “Egyszerű járványterjedési modelleket bemutató szoftver fejlesztése .” Thesis, University of Debrecen. Accessed January 22, 2021. http://hdl.handle.net/2437/201806.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kapitanov, Eszter. “Egyszerű járványterjedési modelleket bemutató szoftver fejlesztése .” Web. 22 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Kapitanov E. Egyszerű járványterjedési modelleket bemutató szoftver fejlesztése . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2437/201806.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Kapitanov E. Egyszerű járványterjedési modelleket bemutató szoftver fejlesztése . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/201806

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Freie Universität Berlin

30. Weimann, Andreas. Use of dynamic fluorescence-flowcytometric parameters for the diagnostics of anemia and sepsis as well as mortalitiy prediction.

Degree: 2017, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6913

► Background: Dynamic fluorescence-flowzytometric parameters of the extended full blood count help with the differential diagnosis of different types of anemia, distinguish patients with and without… (more)

▼ Background: Dynamic fluorescence-flowzytometric parameters of the extended full blood count help with the differential diagnosis of different types of anemia, distinguish patients with and without infection, differentiate between bacterial and viral infections and particularly serve for realtime theragnostics and guidance of anti-infective chemotherapy in sepsis. Additionally, these cellular parameters can be employed for prognosis assessment and mortality prediction in newborns as well as in adult patients. Methods: Cohorts of patients with different types of anemia as well as „blood- healthy“ newborns and adults were compared to each other. Reference values were established for Ret-He and Delta-He for the different patient populations and kinetics of those parameters were depicted in the 9-field hemaplot for single patients under therapy. In addition, the ICIS Score (Intensive Care Infection Score), consisting of a couple of cellular parameters, was tested in a clinical study and was compared to protein biomarkers (CRP und PCT) for infectious medical diagnostics and therapeutic guidance in ICU patients. Finally, the predictive value of NRBC-concentrations (erythroblasts) was determined for VLBW (very low birth weight) newborns regarding mortality and outcome. Results: By use of the parameters Ret-He and Delta-He differentiating between different types of anemia was possible. Both markers significantly differentiated between „blood-healthy“ adults and newborns, as well as patients suffering from iron deficiency anemia (IDA) from chronic anemia (ACD), hemoglobinopathy/thalassemia and their respective states without or under therapy. The hemaplot allowed for the kinetic tracking of Ret-He and Delta-He of anemic patients under therapy. The ICIS-score and its parameters made it possible to distinguish between inflammation and infection, between bacterial and viral infection, enabled monitoring of the effectivity of an anti-infective chemotherapy as well as assessing the patient‘s prognosis. NRBC-concentrations of > 2/nL proved to be the best cut-off value for mortality prediction with a sensitivity of 85% and a specificity of 75% in newborns. Conclusions: Cellular markers of the extended full blood count are a form of analytics which is fast, standardized and available at a 24/7 basis for the differential diagnosis of anemia, realtime-theragnostics in patients with SIRS and sepsis as well as for prognosis assessment and mortality prediction in newborns. Advisors/Committee Members: m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: hemaplot; ICIS, SIRS, sepsis; diagnostics of anemia; Ret-Hb; delta-Hb; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Weimann, A. (2017). Use of dynamic fluorescence-flowcytometric parameters for the diagnostics of anemia and sepsis as well as mortalitiy prediction. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6913

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weimann, Andreas. “Use of dynamic fluorescence-flowcytometric parameters for the diagnostics of anemia and sepsis as well as mortalitiy prediction.” 2017. Thesis, Freie Universität Berlin. Accessed January 22, 2021. http://dx.doi.org/10.17169/refubium-6913.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weimann, Andreas. “Use of dynamic fluorescence-flowcytometric parameters for the diagnostics of anemia and sepsis as well as mortalitiy prediction.” 2017. Web. 22 Jan 2021.

Vancouver:

Weimann A. Use of dynamic fluorescence-flowcytometric parameters for the diagnostics of anemia and sepsis as well as mortalitiy prediction. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Jan 22]. Available from: http://dx.doi.org/10.17169/refubium-6913.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weimann A. Use of dynamic fluorescence-flowcytometric parameters for the diagnostics of anemia and sepsis as well as mortalitiy prediction. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-6913

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations