subject:(SERS substrate)

University of Alberta

1. Kandakkathara, Archana A. High Sensitivity Surface Enhanced Raman Scattering Detection of Tryptophan.

Degree: PhD, Department of Electrical and Computer Engineering, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/c247dt572

► Raman spectroscopy has the capability of providing detailed information about molecular structure, but the extremely small cross section of Raman scattering prevents this technique from… (more)

▼ Raman spectroscopy has the capability of providing detailed information about molecular structure, but the extremely small cross section of Raman scattering prevents this technique from applications requiring high sensitivity. Surface enhanced Raman scattering (SERS) on the other hand provides strongly increased Raman signal from molecules attached to metallic nanostructures and thus a promising technique for high sensitivity analytical applications. However, there are issues which have to be addressed in order to make SERS a reliable technique such as the optimization of conditions for any given analyte, understanding the kinetic processes of binding of the target molecules to the nanostructures and understanding the evolution and coagulation of the nanostructures, in the case of colloidal solutions. In the present thesis the goal was to develop very sensitive SERS techniques for the measurement of biomolecules of interest for analysis of the contents of cells. The techniques explored could be eventually be applicable to microfluidic systems with the ultimate goal of analyzing the molecular constituents of single cells. A high sensitivity detection system based on SERS has been developed and spectrum from tryptophan (Trp) amino acid at very low concentration (10^−8 M) has been detected. The concentration at which good quality SERS spectra could be detected from Trp is 4 orders of magnitude smaller than that previously reported in literature. A study on background electrolytes in the solution which has a significant role in SERS experiment has also been carried out. Optimization of electrolytes leads to the high enhancement reported in this thesis. The SERS detection has also been performed in microfluidic and flow cell geometries which enable a combination of high sensitivity of the SERS with the low volume requirements of microfluidic devices. A Teflon AF capillary was used for performing liquid core waveguide (LCW) SERS measurements and with this geometry the enhancement obtained was increased by a factor of 10. The enhanced sensitivity and better understanding of the optimum conditions for SERS developed in the thesis are important since they now could allow the possibility of assays of the chemical constituents of single cells in future microfluidic systems.

Subjects/Keywords: Surface enhanced Raman scattering (SERS); Microfluidic chip; SERS substrate; Tryptophan; Teflon AF capillary; Liquid core waveguide; Silver colloid; Raman scattering

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APA (6^th Edition):

Kandakkathara, A. A. (2012). High Sensitivity Surface Enhanced Raman Scattering Detection of Tryptophan. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c247dt572

Chicago Manual of Style (16^th Edition):

Kandakkathara, Archana A. “High Sensitivity Surface Enhanced Raman Scattering Detection of Tryptophan.” 2012. Doctoral Dissertation, University of Alberta. Accessed January 20, 2021. https://era.library.ualberta.ca/files/c247dt572.

MLA Handbook (7^th Edition):

Kandakkathara, Archana A. “High Sensitivity Surface Enhanced Raman Scattering Detection of Tryptophan.” 2012. Web. 20 Jan 2021.

Vancouver:

Kandakkathara AA. High Sensitivity Surface Enhanced Raman Scattering Detection of Tryptophan. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2021 Jan 20]. Available from: https://era.library.ualberta.ca/files/c247dt572.

Council of Science Editors:

Kandakkathara AA. High Sensitivity Surface Enhanced Raman Scattering Detection of Tryptophan. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/c247dt572

2. Dridi, Hamida. Méthodologies pour la réalisation d'un substrat SERS à base de silicium poreux pour la détection de molécules chimiques et biologiques : Methodologies used for realization SERS substrate based on porous silicon for chemical and biological molecules detection.

Degree: Docteur es, Physique, 2015, Rennes 1; Université de Tunis El Manar

URL: http://www.theses.fr/2015REN1S012

►

Le travail de cette thèse porte sur la réalisation de substrats SERS (Surface Enhanced Raman Scattering) pour la détection d'espèce chimiques et biologiques. Il s'agit… (more)

▼

Le travail de cette thèse porte sur la réalisation de substrats SERS (Surface Enhanced Raman Scattering) pour la détection d'espèce chimiques et biologiques. Il s'agit de mettre en place des méthodologies utilisant comme surface de départ celle d'une couche poreuse de silicium et un effet de Plasmon de surface induit par la présence d'un métal noble en général. Les spécificités des couches poreuses qui sont d'une part une rugosité nanométrique et d'autre part une porosité et donc une surface interne modulable ont une incidence directe sur la sensibilité de détection de molécules cibles. Nous avons développé dans ce manuscrit de thèse différentes méthodes d'élaboration de substrats SERS à base de couches poreuses de silicium. Nous avons envisagé deux voies, la première se base sur l'utilisation des nanoparticules d'or en solution colloïdale. La deuxième voie, plus originale, utilise le dépôt d'or par pulvérisation cathodique sur une couche poreuse préparée sur la face rugueuse de silicium. Des résultats SERS intéressants, concernant la détection de molécules chimique (Rhodamine 6G) et biologique (Albumine Sérum Bovin), ont été décrits et expliqués permettant d'envisager diverses solutions afin de les optimiser.

The work of this thesis focuses on the realization of SERS substrates (Surface Enhanced Raman Scattering) for the detection of chemical and biological species. This is to implement the methodologies using as the starting surface of a porous silicon layer and a surface Plasmon effect induced by the presence of a noble metal in general. The specificities of the porous layers which are firstly a nanometer roughness and secondly a porosity and therefore an inner surface have a direct impact on the target molecule detection sensitivity. We have developed in this PhD thesis different substrates development methodologies SERS-based on porous silicon layers. We considered two ways, the first is based on the use of gold nanoparticles in colloidal solution. The second route, more original, uses the deposition of gold by sputtering on a porous layer prepared on the rough side of a silicon wafer. Interesting SERS results regarding the detection of chemical (Rhodamine 6G) and biological (Bovin Serum Albumin) molecules, have been described and explained for considering various solutions to optimize them.

Advisors/Committee Members: Haji, Mohamed Lazhar (thesis director), Moadhen, Adel (thesis director).

Subjects/Keywords: Raman spectroscopie; Substrat SERS; Silicium poreux; Rugosité; Nanoparticules d'or; Bio-Détection; Raman spectroscopy; SERS substrate; Porous silicon; Gold nanoparticles; Bio-Detection

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APA (6^th Edition):

Dridi, H. (2015). Méthodologies pour la réalisation d'un substrat SERS à base de silicium poreux pour la détection de molécules chimiques et biologiques : Methodologies used for realization SERS substrate based on porous silicon for chemical and biological molecules detection. (Doctoral Dissertation). Rennes 1; Université de Tunis El Manar. Retrieved from http://www.theses.fr/2015REN1S012

Chicago Manual of Style (16^th Edition):

Dridi, Hamida. “Méthodologies pour la réalisation d'un substrat SERS à base de silicium poreux pour la détection de molécules chimiques et biologiques : Methodologies used for realization SERS substrate based on porous silicon for chemical and biological molecules detection.” 2015. Doctoral Dissertation, Rennes 1; Université de Tunis El Manar. Accessed January 20, 2021. http://www.theses.fr/2015REN1S012.

MLA Handbook (7^th Edition):

Dridi, Hamida. “Méthodologies pour la réalisation d'un substrat SERS à base de silicium poreux pour la détection de molécules chimiques et biologiques : Methodologies used for realization SERS substrate based on porous silicon for chemical and biological molecules detection.” 2015. Web. 20 Jan 2021.

Vancouver:

Dridi H. Méthodologies pour la réalisation d'un substrat SERS à base de silicium poreux pour la détection de molécules chimiques et biologiques : Methodologies used for realization SERS substrate based on porous silicon for chemical and biological molecules detection. [Internet] [Doctoral dissertation]. Rennes 1; Université de Tunis El Manar; 2015. [cited 2021 Jan 20]. Available from: http://www.theses.fr/2015REN1S012.

Council of Science Editors:

Dridi H. Méthodologies pour la réalisation d'un substrat SERS à base de silicium poreux pour la détection de molécules chimiques et biologiques : Methodologies used for realization SERS substrate based on porous silicon for chemical and biological molecules detection. [Doctoral Dissertation]. Rennes 1; Université de Tunis El Manar; 2015. Available from: http://www.theses.fr/2015REN1S012

Duke University

3. Ngo, Hoan. Development of Nucleic Acid Detection Methods and Systems Using Nanobiosensors and Surface-enhanced Raman Spectroscopy for In Vitro Molecular Diagnostics .

Degree: 2017, Duke University

URL: http://hdl.handle.net/10161/14537

► The development of new nucleic acid detection techniques for molecular diagnostics at the point-of-care (POC) and resource-limited settings has attracted great interest. Signal amplification-based… (more)

▼ The development of new nucleic acid detection techniques for molecular diagnostics at the point-of-care (POC) and resource-limited settings has attracted great interest. Signal amplification-based nucleic acid detection can be an alternative to enzymatic amplification-based methods (e.g., PCR, i.e., polymerase chain reaction). Compared to enzymatic amplification, some advantages of signal amplification include simple detection workflow without the need of nucleic acid extraction and purification, being more resistant to contamination and inhibitors, etc. However, current signal amplification methods are usually not sufficiently sensitive or too complicated and require skill operators, thus affecting its translation to POC applications. Advances in nanotechnology and nanomaterials offer new, versatile, and exciting platforms for POC diagnostics. Using nanobiosensors and surface-enhanced Raman scattering (SERS), we have been developing various novel nucleic acid detection methods for in vitro molecular diagnostics. Emphasis was placed on sensitivity and easy-to-use, two of the main requirements of POC molecular diagnostics. Two different and complementary strategies for nucleic acid detection including (1) a chip-based strategy and (2) a nanoparticle-based strategy were investigated. The chip-based strategy involves single-step multiplex detection using SERS-active Nanowave chips. The nanoparticle-based strategy involves sandwich hybridization using magnetic beads, target sequences, and SERS nanorattle nanoparticles. First, we developed a method for fabrication of large area high enhancement SERS-active Nanowave chip. Using the method, wafer scale of SERS-active Nanowave chip with particularly high enhancement factor of ~108 were achieved. Based on the Nanowave chip platform, we developed molecular sentinel-on-chip assay and inverse molecular sentinel-on-chip assay for nucleic acid detection. To show the assays’ usefulness for molecular diagnostics, genetic biomarkers for respiratory infection and a specific DNA sequence of Dengue virus were used as test models. Second, method for synthesis of ultrabright SERS nanorattles were developed. The nanorattles are suitable for sandwich hybridization-based nucleic acid detection due to its strong SERS signal and high stability. Using the synthesized nanorattles, we developed a sandwich hybridization assay to detect specific DNA sequence of malaria parasite P. falciparum and genetic biomarker of squamous cell carcinoma (SCC). For the malaria target DNA, detection limit of 3 pM using synthetic DNA was achieved. For the SCC biomarker, we could detect real biological samples by detecting real-time PCR products of RNA extracted from SCC cell lines. Sensitivity of 93% and specificity of 100% were achieved. Third, we developed an integrated device for automation of the nanorattle sandwich assay. Using the device, we could directly detect malaria RNA in malaria-infected blood lysate. The detection process was quite simple by adding nanorattles… Advisors/Committee Members: Vo-Dinh, Tuan (advisor).

Subjects/Keywords: Biomedical engineering; Molecular Diagnostics; Nanobiosensors; Nucleic acid detection; SERS nanotag; SERS substrate; Surface-enhanced Raman scattering

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APA (6^th Edition):

Ngo, H. (2017). Development of Nucleic Acid Detection Methods and Systems Using Nanobiosensors and Surface-enhanced Raman Spectroscopy for In Vitro Molecular Diagnostics . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/14537

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ngo, Hoan. “Development of Nucleic Acid Detection Methods and Systems Using Nanobiosensors and Surface-enhanced Raman Spectroscopy for In Vitro Molecular Diagnostics .” 2017. Thesis, Duke University. Accessed January 20, 2021. http://hdl.handle.net/10161/14537.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ngo, Hoan. “Development of Nucleic Acid Detection Methods and Systems Using Nanobiosensors and Surface-enhanced Raman Spectroscopy for In Vitro Molecular Diagnostics .” 2017. Web. 20 Jan 2021.

Vancouver:

Ngo H. Development of Nucleic Acid Detection Methods and Systems Using Nanobiosensors and Surface-enhanced Raman Spectroscopy for In Vitro Molecular Diagnostics . [Internet] [Thesis]. Duke University; 2017. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/10161/14537.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ngo H. Development of Nucleic Acid Detection Methods and Systems Using Nanobiosensors and Surface-enhanced Raman Spectroscopy for In Vitro Molecular Diagnostics . [Thesis]. Duke University; 2017. Available from: http://hdl.handle.net/10161/14537

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. HE SHUAI. GOLD NANOSTARS AS A SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATE FOR BIOSENSING APPLICATIONS.

Degree: 2017, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/138601

Subjects/Keywords: SERS; gold nanostar; substrate; biosensing; optimization

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APA (6^th Edition):

SHUAI, H. (2017). GOLD NANOSTARS AS A SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATE FOR BIOSENSING APPLICATIONS. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/138601

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SHUAI, HE. “GOLD NANOSTARS AS A SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATE FOR BIOSENSING APPLICATIONS.” 2017. Thesis, National University of Singapore. Accessed January 20, 2021. http://scholarbank.nus.edu.sg/handle/10635/138601.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SHUAI, HE. “GOLD NANOSTARS AS A SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATE FOR BIOSENSING APPLICATIONS.” 2017. Web. 20 Jan 2021.

Vancouver:

SHUAI H. GOLD NANOSTARS AS A SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATE FOR BIOSENSING APPLICATIONS. [Internet] [Thesis]. National University of Singapore; 2017. [cited 2021 Jan 20]. Available from: http://scholarbank.nus.edu.sg/handle/10635/138601.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SHUAI H. GOLD NANOSTARS AS A SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATE FOR BIOSENSING APPLICATIONS. [Thesis]. National University of Singapore; 2017. Available from: http://scholarbank.nus.edu.sg/handle/10635/138601

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

5. Goldshlag, Ilya. Surface wetting methods compatible with solid SERS substrates.

Degree: MS, 1200, 2013, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/42477

► Nanopatterned metal surfaces are widely used for surface-enhanced Raman spectroscopy (SERS). Effectiveness of the sensors depends on how well ligand and analyte molecules can diffuse… (more)

Subjects/Keywords: urface-enhanced Raman spectroscopy (SERS) substrate wetting; solid urface-enhanced Raman spectroscopy (SERS) substrates; nanopatterned gold surface wetting; ethanol; oxygen plasma; surfactants; hydrophilic monolayer; contact angle; DNA aptamers

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APA (6^th Edition):

Goldshlag, I. (2013). Surface wetting methods compatible with solid SERS substrates. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/42477

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Goldshlag, Ilya. “Surface wetting methods compatible with solid SERS substrates.” 2013. Thesis, University of Illinois – Urbana-Champaign. Accessed January 20, 2021. http://hdl.handle.net/2142/42477.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Goldshlag, Ilya. “Surface wetting methods compatible with solid SERS substrates.” 2013. Web. 20 Jan 2021.

Vancouver:

Goldshlag I. Surface wetting methods compatible with solid SERS substrates. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2013. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/2142/42477.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Goldshlag I. Surface wetting methods compatible with solid SERS substrates. [Thesis]. University of Illinois – Urbana-Champaign; 2013. Available from: http://hdl.handle.net/2142/42477

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

6. Benford, Melodie Elane. Development of a Surface Enhanced Raman Spectroscopy Platform Technology to Detect Cardiac Biomarkers of Myocardial Infarction.

Degree: PhD, Biomedical Engineering, 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/149427

► The clinical evaluation of people with possible myocardial infarction (MI) is often limited by atypical symptoms and inconclusive initial electrocardiograms. A recent consensus from the… (more)

Subjects/Keywords: Surface enhanced Raman spectroscopy; nanotechnology; cardiac biomarkers; gold colloid; SERS substrate; Raman spectrosopy; point-of-care diagnostics

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APA (6^th Edition):

Benford, M. E. (2013). Development of a Surface Enhanced Raman Spectroscopy Platform Technology to Detect Cardiac Biomarkers of Myocardial Infarction. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/149427

Chicago Manual of Style (16^th Edition):

Benford, Melodie Elane. “Development of a Surface Enhanced Raman Spectroscopy Platform Technology to Detect Cardiac Biomarkers of Myocardial Infarction.” 2013. Doctoral Dissertation, Texas A&M University. Accessed January 20, 2021. http://hdl.handle.net/1969.1/149427.

MLA Handbook (7^th Edition):

Benford, Melodie Elane. “Development of a Surface Enhanced Raman Spectroscopy Platform Technology to Detect Cardiac Biomarkers of Myocardial Infarction.” 2013. Web. 20 Jan 2021.

Vancouver:

Benford ME. Development of a Surface Enhanced Raman Spectroscopy Platform Technology to Detect Cardiac Biomarkers of Myocardial Infarction. [Internet] [Doctoral dissertation]. Texas A&M University; 2013. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/1969.1/149427.

Council of Science Editors:

Benford ME. Development of a Surface Enhanced Raman Spectroscopy Platform Technology to Detect Cardiac Biomarkers of Myocardial Infarction. [Doctoral Dissertation]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/149427

7. Bae, Justin. Flexible Plasmonic Sensing Substrates and their application in Explosive Sensing.

Degree: MS, Mechanical Engineering & Materials Science, 2017, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/231

► With an increasing use of improvised explosive devices in combat and terrorism, there is an urgent need for novel methods of trace explosive detection… (more)

Subjects/Keywords: Plasmonics; Nanoscience; Explosive; SERS; Flexible Substrate; Engineering

…Introduction In this chapter, we report results from cysteamine and peptide modified SERS substrate… …SERS Substrate 1. Paper-based SERS substrates The synthesized AuNRs were adsorbed onto… …for the cysteamine functionalized AuNR- paper to be used as a SERS substrate. 14… …SERS substrate, then these samples of AuNR- paper exposed to different concentrations of TNT… …SERS substrate and a sustainable material in optics and photonics, electronics and…

11 more images…

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APA (6^th Edition):

Bae, J. (2017). Flexible Plasmonic Sensing Substrates and their application in Explosive Sensing. (Thesis). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/231

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bae, Justin. “Flexible Plasmonic Sensing Substrates and their application in Explosive Sensing.” 2017. Thesis, Washington University in St. Louis. Accessed January 20, 2021. https://openscholarship.wustl.edu/eng_etds/231.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bae, Justin. “Flexible Plasmonic Sensing Substrates and their application in Explosive Sensing.” 2017. Web. 20 Jan 2021.

Vancouver:

Bae J. Flexible Plasmonic Sensing Substrates and their application in Explosive Sensing. [Internet] [Thesis]. Washington University in St. Louis; 2017. [cited 2021 Jan 20]. Available from: https://openscholarship.wustl.edu/eng_etds/231.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bae J. Flexible Plasmonic Sensing Substrates and their application in Explosive Sensing. [Thesis]. Washington University in St. Louis; 2017. Available from: https://openscholarship.wustl.edu/eng_etds/231

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tennessee – Knoxville

8. Bhandari, Deepak. Surface-Enhanced Raman Scattering: Substrate Development and Applications in Analytical Detection.

Degree: 2011, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_graddiss/949

► To advance the capabilities of surface-enhanced Raman scattering (SERS), we developed a silver modified polypropylene filter (AgPPF) substrate which acts as a pseudo stationary phase… (more)

▼ To advance the capabilities of surface-enhanced Raman scattering (SERS), we developed a silver modified polypropylene filter (AgPPF) substrate which acts as a pseudo stationary phase in harvesting SERS signatures of so called "phytochemical estrogens" and other environmentally significant chemicals. To augment electron beam lithography (EBL) in SERS research, we also introduced an interesting nanotransfer printing (nTP) technique which could circumvent the low throughput and extremely high resolution (< 10 nm) limitations of EBL in designing advanced SERS substrates. In our study, a nominal average thickness of 10 nm silver on the polypropylene microfiber produced nanoglobules of less than 100 nm in diameter. This noble metal nanoroughened layer allowed AgPPF to serve as a SERS active substrate, onto which the noted endocrine disrupting chemicals were passed through and harvested. The intense, multifeatured vibrational Raman spectra of very rarely SERS studied chemical species collected indicates the potential for useful detection via this approach of creating SERS substrates. AgPPF substrates were also used in characterizing the adsorption behavior of hydroxyl complexes of uranium. Interestingly, hydroxyl group on the uranium complexes showed slow sorption kinetics on the nanostructured silver surfaces. Understanding the adsorption behavior of aqueous solution of uranium on nanostructured silver surfaces has opened up the possibilities of SERS detection of these environmental and non-proliferation concerned species without any surface modifications. nTP is a high resolution printing technique and relies on interfacial chemistries to control the transfer of thin metal film from a "stamp" to a "substrate". In our research, high-aspect-ratio AutoCAD designed nanopatterns were created on silicon wafers using e-beam lithography and reactive ion etching. Silicon relief pillars based stamps were then used to integrate a variety of nanostructures on different dielectric materials. Thus created nanopatterns have shown their promise to hold their inherent SERS activity. For its simplicity, cost-effectiveness, and ease of operation, this hyphenated nTP-SERS technique is impressive in the selection of suitable supporting-films for better SERS enhancements and also to manipulate gap between nanodiscs (gap-plasmonic SERS effect).

Subjects/Keywords: Surface-enhanced Raman; SERS Substrate; Nanofabrication; Electron beam lithography; Nanotransfer printing; Polypropylene filter; Analytical Chemistry; Chemistry; Environmental Chemistry; Materials Chemistry

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APA (6^th Edition):

Bhandari, D. (2011). Surface-Enhanced Raman Scattering: Substrate Development and Applications in Analytical Detection. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/949

Chicago Manual of Style (16^th Edition):

Bhandari, Deepak. “Surface-Enhanced Raman Scattering: Substrate Development and Applications in Analytical Detection.” 2011. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed January 20, 2021. https://trace.tennessee.edu/utk_graddiss/949.

MLA Handbook (7^th Edition):

Bhandari, Deepak. “Surface-Enhanced Raman Scattering: Substrate Development and Applications in Analytical Detection.” 2011. Web. 20 Jan 2021.

Vancouver:

Bhandari D. Surface-Enhanced Raman Scattering: Substrate Development and Applications in Analytical Detection. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2011. [cited 2021 Jan 20]. Available from: https://trace.tennessee.edu/utk_graddiss/949.

Council of Science Editors:

Bhandari D. Surface-Enhanced Raman Scattering: Substrate Development and Applications in Analytical Detection. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2011. Available from: https://trace.tennessee.edu/utk_graddiss/949

9. Ranginwala, Saadia. Optical Detection of Immunoglobulin E.

Degree: 2013, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/9719

► Aptamers have a wide range of applications in clinical applications. A review of aptamers, and their applications has been given. Immunoglobulin E is an antibody… (more)

Subjects/Keywords: Aptamer; Antibody; Immunoglobulin E; Raman Spectroscopy; Substrate Enhanced Raman Spectroscopy; SERS

…the aptamer, in solution form, were applied to a different well in the SERS substrate. The… …minutes. The SERS substrate with the loaded samples was then taken to do SERS. The Raman imaging… …angle deposition. The SERS substrate was designed in a way that the wells in the substrate… …4.1 Raman and Surface Enhanced Raman Spectroscopy (SERS) Raman spectroscopy is the… …this enhanced scattering is called Surface Enhanced Raman Scattering (SERS) […

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APA (6^th Edition):

Ranginwala, S. (2013). Optical Detection of Immunoglobulin E. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/9719

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ranginwala, Saadia. “Optical Detection of Immunoglobulin E.” 2013. Thesis, University of Illinois – Chicago. Accessed January 20, 2021. http://hdl.handle.net/10027/9719.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ranginwala, Saadia. “Optical Detection of Immunoglobulin E.” 2013. Web. 20 Jan 2021.

Vancouver:

Ranginwala S. Optical Detection of Immunoglobulin E. [Internet] [Thesis]. University of Illinois – Chicago; 2013. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/10027/9719.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ranginwala S. Optical Detection of Immunoglobulin E. [Thesis]. University of Illinois – Chicago; 2013. Available from: http://hdl.handle.net/10027/9719

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

10. Ostovar Pour, Saeideh. Advanced vibrational spectroscopic studies of biological molecules.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/advanced-vibrational-spectroscopic-studies-of-biological-molecules(2e77df15-e7e0-4def-85f4-da996fbb6671).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555523

► Raman optical activity (ROA) is a powerful probe of the structure and behaviour of biomolecules in aqueous solution for a number of important problems in… (more)

▼ Raman optical activity (ROA) is a powerful probe of the structure and behaviour of biomolecules in aqueous solution for a number of important problems in molecular biology. Although ROA is a very sensitive technique for studying biological samples, it is a very weak effect and the conditions of high concentration and long data collection time required limit its application for a wide range of biological samples. These limitations could possibly be overcome using the principle of surface enhanced Raman scattering (SERS). The combination of ROA with SERS in the form of surface enhanced ROA (SEROA) could be a solution for widening the application of ROA. In the last few years, the generation of reliable SEROA spectra of biomolecules has been problematic due to non-homogenous colloidal systems forming and low signal-to-noise ratios which complicated detection of the true SEROA signal from the analyte. L- and D-enantiomers give full or partially mirror image chiroptical spectra, this property of enantiomers can be employed to prove the chiroptical activity of the SEROA technique. In this thesis we employed a hydrophilic polycarbopol polymer as stabilising media which has led to the first report of mirror image SEROA bands for enantiomeric structures. This new technique of incorporating the hydrogel polymer as a means to stabilise the colloidal system has proven to be reliable in obtaining high quality SEROA spectra of D- and L-enantiomers of ribose and tryptophan. In an extension of the hydrogel-stabilised SEROA work, we also demonstrate that single nanoparticle plasmonic substrate such as silver silica nanotags can enhance the weak ROA effect. These dye tagged silica coated silver nanoparticles have enabled a chiral response to be transmitted from a chiral analyte to the plasmon resonance of an achiral metallic nanostructure. The measurement of mirror image SERROA bands for the two enantiomers of each of ribose and tryptophan was confirmed for this system. The generation of SEROA for both systems was achieved and confirmed SEROA as a new sensitive tool for analysis of biomolecular structure. In a related project, Raman and ROA spectra were measured for adenosine and seven of its derivative ribonucleotides. Both of these spectroscopic techniques are shown to be sensitive to the site and degree of phosphorylation, with a considerable number of marker bands being identified for these ribonucleotides. Moreover, the SERS studies of these ribonucleotides were also performed. The obtained SERS spectra were shown similar features that confirm these analytes interact with the surface in a similar manner, hence limiting the structural sensitivity of this method towards phosphate position. Short dipeptides such as diketopiperazine (DKP) have been investigated during the last decades as both natural and synthetic DKPs have a wide variety of biological activities. Raman and ROA spectra of linear and cyclic dialanine and diserine were measured to charecterize their solution structures. Density functional theory (DFT) calculations were…

Subjects/Keywords: 535.846; Raman; Raman optical activity (ROA); Surface enhanced Raman spectroscopy (SERS); Surface enhanced ROA (SEROA); Chirality; Enantiomers; Ribose; Tryptophan; Single plasmonic substrate; Silver silica nanotag; Ribonucleotides; Phosphorylation detection; Silver colloids; Linear and cyclic short dipeptides; dialanine; diserine

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APA (6^th Edition):

Ostovar Pour, S. (2012). Advanced vibrational spectroscopic studies of biological molecules. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/advanced-vibrational-spectroscopic-studies-of-biological-molecules(2e77df15-e7e0-4def-85f4-da996fbb6671).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555523

Chicago Manual of Style (16^th Edition):

Ostovar Pour, Saeideh. “Advanced vibrational spectroscopic studies of biological molecules.” 2012. Doctoral Dissertation, University of Manchester. Accessed January 20, 2021. https://www.research.manchester.ac.uk/portal/en/theses/advanced-vibrational-spectroscopic-studies-of-biological-molecules(2e77df15-e7e0-4def-85f4-da996fbb6671).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555523.

MLA Handbook (7^th Edition):

Ostovar Pour, Saeideh. “Advanced vibrational spectroscopic studies of biological molecules.” 2012. Web. 20 Jan 2021.

Vancouver:

Ostovar Pour S. Advanced vibrational spectroscopic studies of biological molecules. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Jan 20]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/advanced-vibrational-spectroscopic-studies-of-biological-molecules(2e77df15-e7e0-4def-85f4-da996fbb6671).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555523.

Council of Science Editors:

Ostovar Pour S. Advanced vibrational spectroscopic studies of biological molecules. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/advanced-vibrational-spectroscopic-studies-of-biological-molecules(2e77df15-e7e0-4def-85f4-da996fbb6671).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555523

Youngstown State University

11. Vabbilisetty, Pratima. Fabrication and Characterization of Substrate Materials for Trace Analytical Measurements by Surface Enhanced Raman Scattering (SERS) Spectroscopy Technique.

Degree: MSin Chemistry, Department of Chemistry, 2008, Youngstown State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ysu1231794465

► The detection of various compounds using Surface enhanced Raman Scattering (SERS) from colloidal suspensions of silver and gold colloids has been attempted. Different substrates have… (more)

Subjects/Keywords: Analytical Chemistry; Chemistry; Electromagnetism; Materials Science; SERS; Raman scattering; fabrication and characterization; substrate materials; trace analytical measurements

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vabbilisetty, P. (2008). Fabrication and Characterization of Substrate Materials for Trace Analytical Measurements by Surface Enhanced Raman Scattering (SERS) Spectroscopy Technique. (Masters Thesis). Youngstown State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ysu1231794465

Chicago Manual of Style (16^th Edition):

Vabbilisetty, Pratima. “Fabrication and Characterization of Substrate Materials for Trace Analytical Measurements by Surface Enhanced Raman Scattering (SERS) Spectroscopy Technique.” 2008. Masters Thesis, Youngstown State University. Accessed January 20, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1231794465.

MLA Handbook (7^th Edition):

Vabbilisetty, Pratima. “Fabrication and Characterization of Substrate Materials for Trace Analytical Measurements by Surface Enhanced Raman Scattering (SERS) Spectroscopy Technique.” 2008. Web. 20 Jan 2021.

Vancouver:

Vabbilisetty P. Fabrication and Characterization of Substrate Materials for Trace Analytical Measurements by Surface Enhanced Raman Scattering (SERS) Spectroscopy Technique. [Internet] [Masters thesis]. Youngstown State University; 2008. [cited 2021 Jan 20]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ysu1231794465.

Council of Science Editors:

Vabbilisetty P. Fabrication and Characterization of Substrate Materials for Trace Analytical Measurements by Surface Enhanced Raman Scattering (SERS) Spectroscopy Technique. [Masters Thesis]. Youngstown State University; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ysu1231794465

12. Appelblad, André. Development of a Temperature Controlled Cell for Surface Enhanced Raman Spectroscopy for in situ Detection of Gases.

Degree: Physics, 2014, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89799

►

This work describes a master’s thesis in engineering physics at Umeå University carried out during the spring semester of 2014. In the thesis the… (more)

▼

This work describes a master’s thesis in engineering physics at Umeå University carried out during the spring semester of 2014. In the thesis the student has constructed and tested a temperature controlled cell for cooling/heating of surface-enhanced-Raman-spectroscopy (SERS) substrates for rapid detection of volatile substances. The thesis was carried out at the Swedish Defence Research Agency (FOI) in Umeå, Sweden. A Linkam Scientific Instruments TS1500 cell was equipped with a Peltier element for cooling/heating and a thermistor temperature sensor. A control system was constructed, based on an Arduino Uno microcontroller board and a pulse-width-modulated (PWM) H-bridge motor driver to control the Peltier element using a proportional-integral (PI) control algorithm. The temperature controlled cell was able to regulate the temperature of a SERS substrate within -15 to +110 °C and maintain the temperature over prolonged periods at ±0.22 °C of the set point temperature. Gas phase of 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane (isoflurane) was flowed through the cell and SERS spectra were collected at different temperatures and concentrations. This test showed that the signal is increased when the substrate is cooled and reversibly decreased when the substrate was heated. Keywords: temperature control, Raman scattering, surface enhanced Raman spectroscopy SERS, SERS substrate, volatile substances, Peltier module, thermistor, PWM, H-bridge, PI(D) control.

Detta dokument beskriver ett examensarbete för civilingenjörsexamen i teknisk fysik vid Umeå Universitet som utförts under vårterminen 2014. I examensarbetet har en kyl-/värmecell för temperaturkontroll av substratytor för ytförstärkt ramanspektroskopi (SERS) för snabb detektion av farliga flyktiga ämnen konstruerats och testats. Arbetet utfördes vid Totalförsvarets forskningsinstitut (FOI) i Umeå, Sverige. Utgångspunkten var ett Linkam Scientific Instruments TS1500 mikroskopsteg, vilket utrustades med ett Peltierelement för kylning/värmning och en termistor för temperaturövervakning. Ett styrsystem baserat på ett Arduino Uno mikrostyrenhetskort konstruerades med ett motordrivkort (H-brygga) vilket använder pulsbreddsmodulering (PWM) för att reglera spänningen till Peltierelementet utifrån en PI-regulator. Den färdiga cellen klarade att reglera temperaturen på ett SERS-substrat i ett temperaturspann på ungefär -15 till +110 °C med en temperaturstabilitet på ±0.22 °C av måltemperaturen. Cellen testades sedan på flyktiga ämnen för att visa dess funktion. Difluorometyl-2,2,2-trifluoro-1-kloroetyleter (isofluran) i gasfas, med instrumentluft som bärargas, flödades genom cellen och SERS-spektra erhölls vid olika koncentrationer och temperaturer. Vid samtliga koncentrationer visades att lägre temperatur ger ökad signalstyrka. När ytan sedan värmdes upp sjönk signalen reversibelt tillbaka till ursprungsvärdet. Nyckelord: temperaturkontroll, ytförstärkt ramanspektroskopi, SERS, flyktiga ämnen, Peltierelement, thermistor, PWM, H-brygga,…

Subjects/Keywords: temperature control; Raman scattering; surface enhanced Raman spectroscopy SERS; SERS substrate; volatile substances; Peltier module; thermistor; PWM; H-bridge; PI(D) control.; temperaturkontroll; ytförstärkt ramanspektroskopi; SERS; flyktiga ämnen; Peltierelement; thermistor; PWM; H-brygga; PI(D)-regulator.

…tested substances were easier to detect after cooling the SERS substrate, which indicates that… …oscillations that are perpendicular to the surface contributes to scattering, so SERS substrate… …heater setup, SERS substrate and temperature sensor all need to fit in that space and still… …SERS substrate will have to be less than maximum working temperature of the thermistor to… …SERS substrate (Klarite®) was placed in the temperature cell on top of the Peltier…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Appelblad, A. (2014). Development of a Temperature Controlled Cell for Surface Enhanced Raman Spectroscopy for in situ Detection of Gases. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Appelblad, André. “Development of a Temperature Controlled Cell for Surface Enhanced Raman Spectroscopy for in situ Detection of Gases.” 2014. Thesis, Umeå University. Accessed January 20, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Appelblad, André. “Development of a Temperature Controlled Cell for Surface Enhanced Raman Spectroscopy for in situ Detection of Gases.” 2014. Web. 20 Jan 2021.

Vancouver:

Appelblad A. Development of a Temperature Controlled Cell for Surface Enhanced Raman Spectroscopy for in situ Detection of Gases. [Internet] [Thesis]. Umeå University; 2014. [cited 2021 Jan 20]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Appelblad A. Development of a Temperature Controlled Cell for Surface Enhanced Raman Spectroscopy for in situ Detection of Gases. [Thesis]. Umeå University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

13. Marotta, Nicole Ella. Patterned nanoarray sers substrates for pathogen detection.

Degree: PhD, Chemistry and Biochemistry, 2010, Georgia Tech

URL: http://hdl.handle.net/1853/37274

► The objectives of the work presented were to 1) fabricate reproducible nanorod array SERS substrates, 2) detection of bacteria using nanorod substrates, 3) detection of… (more)

▼ The objectives of the work presented were to 1) fabricate reproducible nanorod array SERS substrates, 2) detection of bacteria using nanorod substrates, 3) detection of DNA hybridization using nanorod substrates and 4) critically evaluate the sensing method. Important findings from this work are as follows. A novel method for batch fabrication of substrates for surface enhanced Raman scattering (SERS) has been developed using a modified platen machined to fit in a commercial electron beam evaporator. The use of this holder enables simultaneous deposition of silver nanorod (AgNR) arrays onto six microscope slide substrates utilizing glancing angle deposition. In addition to multiple substrate fabrication, patterning of the AgNR substrates with 36 wells allows for physical isolation of low volume samples. The well-to-well, slide-to-slide, and batch-to-batch variability in both physical characteristics and SERS response of substrates prepared via this method was nominal. A critical issue in the continued development of AgNR substrates is their stability over time, and the potential impact on the SERS response. The thermal stability of the arrays was investigated and changes in surface morphology were evaluated using scanning electron microscopy and x-ray diffraction and correlated with changes in SERS enhancement. The findings suggest that the shelf-life of AgNR arrays is limited by migration of silver on the surface. Continued characterization of the AgNR arrays was carried out using fluorescent polystyrene microspheres of two different sizes. Theory suggests that enhancement between nanorods would be significantly greater than at the tops due to contributing electromagnetic fields from each nanostructure. In contrast to the theory, SERS response of microspheres confined to the tops of the AgNR array was significantly greater than that for beads located within the array. The location of the microspheres was established using optical fluorescence and scanning electron microscopy. The application of SERS to characterizing pathogens such as bacteria and viruses is an active area of investigation. AgNR array-based SERS substrates have enabled detection of pathogens present in biofluids. Specifically, several publications have focused on determining the spectral bands characteristic of bacteria from different species and cell lines. Studies were carried out on three strains of bacteria as well as the medium in which the bacteria were grown. The spectra of the bacteria and medium were surprisingly similar, so additional spectra were acquired for commonly used bacterial growth media. In many instances, these spectra were similar to published spectra purportedly characteristic of specific bacterial species. In addition to bacterial samples, nucleic acid hybridization assays were investigated. Oligonucleotide pairs specifically designed to detect respiratory syncytial virus (RSV) in nasal fluids were prepared and evaluated. SERS spectra acquired on oligos, alone or in combination, contain the… Advisors/Committee Members: Lawrence Bottomley (Committee Chair), Julia Kubanek (Committee Member), L. Andrew Lyon (Committee Member), Loren Williams (Committee Member), Mostafa El-Sayed (Committee Member).

Subjects/Keywords: Silver nanostructure; Surface enhanced Raman scattering; Silver nanorod array; Surface enhanced Raman spectroscopy; Oblique angle deposition; Glancing angle deposition; SERS substrate; Raman effect; Raman spectroscopy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marotta, N. E. (2010). Patterned nanoarray sers substrates for pathogen detection. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/37274

Chicago Manual of Style (16^th Edition):

Marotta, Nicole Ella. “Patterned nanoarray sers substrates for pathogen detection.” 2010. Doctoral Dissertation, Georgia Tech. Accessed January 20, 2021. http://hdl.handle.net/1853/37274.

MLA Handbook (7^th Edition):

Marotta, Nicole Ella. “Patterned nanoarray sers substrates for pathogen detection.” 2010. Web. 20 Jan 2021.

Vancouver:

Marotta NE. Patterned nanoarray sers substrates for pathogen detection. [Internet] [Doctoral dissertation]. Georgia Tech; 2010. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/1853/37274.

Council of Science Editors:

Marotta NE. Patterned nanoarray sers substrates for pathogen detection. [Doctoral Dissertation]. Georgia Tech; 2010. Available from: http://hdl.handle.net/1853/37274

14. Ostovar Pour, Saeideh. ADVANCED VIBRATIONAL SPECTROSCOPIC STUDIES OF BIOLOGICAL MOLECULES.

Degree: 2012, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:164952

► Raman optical activity (ROA) is a powerful probe of the structure and behaviour of biomolecules in aqueous solution for a number of important problems in… (more)

▼ Raman optical activity (ROA) is a powerful probe of the structure and behaviour of biomolecules in aqueous solution for a number of important problems in molecular biology. Although ROA is a very sensitive technique for studying biological samples, it is a very weak effect and the conditions of high concentration and long data collection time required limit its application for a wide range of biological samples. These limitations could possibly be overcome using the principle of surface enhanced Raman scattering (SERS). The combination of ROA with SERS in the form of surface enhanced ROA (SEROA) could be a solution for widening the application of ROA. In the last few years, the generation of reliable SEROA spectra of biomolecules has been problematic due to non-homogenous colloidal systems forming and low signal-to-noise ratios which complicated detection of the true SEROA signal from the analyte. L- and D-enantiomers give full or partially mirror image chiroptical spectra, this property of enantiomers can be employed to prove the chiroptical activity of the SEROA technique. In this thesis we employed a hydrophilic polycarbopol polymer as stabilising media which has led to the first report of mirror image SEROA bands for enantiomeric structures. This new technique of incorporating the hydrogel polymer as a means to stabilise the colloidal system has proven to be reliable in obtaining high quality SEROA spectra of D- and L-enantiomers of ribose and tryptophan. In an extension of the hydrogel-stabilised SEROA work, we also demonstrate that single nanoparticle plasmonic substrate such as silver silica nanotags can enhance the weak ROA effect. These dye tagged silica coated silver nanoparticles have enabled a chiral response to be transmitted from a chiral analyte to the plasmon resonance of an achiral metallic nanostructure. The measurement of mirror image SERROA bands for the two enantiomers of each of ribose and tryptophan was confirmed for this system. The generation of SEROA for both systems was achieved and confirmed SEROA as a new sensitive tool for analysis of biomolecular structure.In a related project, Raman and ROA spectra were measured for adenosine and seven of its derivative ribonucleotides. Both of these spectroscopic techniques are shown to be sensitive to the site and degree of phosphorylation, with a considerable number of marker bands being identified for these ribonucleotides. Moreover, the SERS studies of these ribonucleotides were also performed. The obtained SERS spectra were shown similar features that confirm these analytes interact with the surface in a similar manner, hence limiting the structural sensitivity of this method towards phosphate position.Short dipeptides such as diketopiperazine (DKP) have been investigated during the last decades as both natural and synthetic DKPs have a wide variety of biological activities. Raman and ROA spectra of linear and cyclic dialanine and diserine were measured to charecterize their solution structures. Density functional theory (DFT) calculations were… Advisors/Committee Members: Blanch, Ewan.

Subjects/Keywords: Raman; Raman optical activity (ROA); Surface enhanced Raman spectroscopy (SERS); Surface enhanced ROA (SEROA); Chirality; Enantiomers; Ribose; Tryptophan; Single plasmonic substrate; Silver silica nanotag; Ribonucleotides; Phosphorylation detection; Silver colloids; Linear and cyclic short dipeptides; dialanine; diserine

…SERS spectra after addition of D- and L-tryptophan (C and D), (0.0002 M)… …of Figures Figure S4.1 SERS spectra of adenosine ribonucleotides and adenosine in the… …enhanced Raman scattering (SERS). The combination of ROA with SERS in the form of… …hydrogel-stabilised SEROA work, we also demonstrate that single nanoparticle plasmonic substrate… …Moreover, the SERS studies of these ribonucleotides were also performed. The obtained SERS…

5 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ostovar Pour, S. (2012). ADVANCED VIBRATIONAL SPECTROSCOPIC STUDIES OF BIOLOGICAL MOLECULES. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:164952

Chicago Manual of Style (16^th Edition):

Ostovar Pour, Saeideh. “ADVANCED VIBRATIONAL SPECTROSCOPIC STUDIES OF BIOLOGICAL MOLECULES.” 2012. Doctoral Dissertation, University of Manchester. Accessed January 20, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:164952.

MLA Handbook (7^th Edition):

Ostovar Pour, Saeideh. “ADVANCED VIBRATIONAL SPECTROSCOPIC STUDIES OF BIOLOGICAL MOLECULES.” 2012. Web. 20 Jan 2021.

Vancouver:

Ostovar Pour S. ADVANCED VIBRATIONAL SPECTROSCOPIC STUDIES OF BIOLOGICAL MOLECULES. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Jan 20]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:164952.

Council of Science Editors:

Ostovar Pour S. ADVANCED VIBRATIONAL SPECTROSCOPIC STUDIES OF BIOLOGICAL MOLECULES. [Doctoral Dissertation]. University of Manchester; 2012. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:164952

Université de Montréal

15. Zhu, Hu. Templating gold nanoparticles on nanofibers using block copolymer thin films.

Degree: 2019, Université de Montréal

URL: http://hdl.handle.net/1866/21701

Subjects/Keywords: SERS; Nanofibres; Polystyrène-bloc-poly(4-vinylpyridine); Adsorption; Trempage; Self-Assembly; Gold Nanoparticles; Substrate Curvature; Dip-Coating; Block Copolymer Adsorption; Block Copolymer Brush Layers; Polystyrene-block-poly(4-vinylpyridine); Block Copolymers; Auto-Assemblage; Nanoparticules D'or; Courbure du Substrat; Couches Minces; Couches de Type Brosse; Thin Films; Copolymères à Blocs; Chemistry - Polymer / Chimie - Polymères (UMI : 0495)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhu, H. (2019). Templating gold nanoparticles on nanofibers using block copolymer thin films. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/21701

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhu, Hu. “Templating gold nanoparticles on nanofibers using block copolymer thin films.” 2019. Thesis, Université de Montréal. Accessed January 20, 2021. http://hdl.handle.net/1866/21701.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhu, Hu. “Templating gold nanoparticles on nanofibers using block copolymer thin films.” 2019. Web. 20 Jan 2021.

Vancouver:

Zhu H. Templating gold nanoparticles on nanofibers using block copolymer thin films. [Internet] [Thesis]. Université de Montréal; 2019. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/1866/21701.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhu H. Templating gold nanoparticles on nanofibers using block copolymer thin films. [Thesis]. Université de Montréal; 2019. Available from: http://hdl.handle.net/1866/21701

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations