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Kansas State University
1.
Sharpe, Emily.
Effect of
oral administration of robenacoxib on experimentally-induced
anterior uveitis in normal cats: Effect of oral administration of robenacoxib on
inhibition of paracentesis-induced blood-aqueous barrier breakdown
in normal cats.
Degree: MSin Biomedical Sciences, Department of Clinical
Sciences, 2018, Kansas State University
URL: http://hdl.handle.net/2097/39015 
► Objectives- To determine the effect of oral robenacoxib on experimentally-induced anterior uveitis, and to evaluate the ability of robenacoxib to cross an intact blood-aqueous barrier.…
(more)
▼ Objectives- To determine the effect of oral
robenacoxib on experimentally-induced anterior uveitis, and to
evaluate the ability of
robenacoxib to cross an intact
blood-aqueous barrier.
Animals- Twelve healthy adult domestic
shorthair cats.
Procedures- Cats in the treatment group (n=6)
received oral
robenacoxib (1.51 ± 0.36 mg/kg ) once daily beginning
1 day before experimental induction of uveitis by anterior chamber
paracentesis (ACP) and continuing 1 day after paracentesis.
Anterior chamber paracentesis was performed using a 30 g needle
attached to a 1 mL syringe, and 100 µL of aqueous humor were
aspirated over 3-5 seconds. Anterior chamber fluorophotometry was
performed in both eyes of each cat immediately before ACP (time 0),
and at 6, 24, and 48 hours after ACP. An independent t-test was
used to compare percent fluorescein increase in treatment versus
control cats at each time point. Values of p<0.05 were
considered significant. Concentrations of
robenacoxib in aqueous
humor were measured using liquid chromatography and mass
spectrometry.
Results- There was no statistically significant
difference between the ACP and control eye at time 0 (p=0.322).
When comparing the percent fluorescein increase between treatment
and control groups, there was no statistically significant
difference at any time point (p>0.05).
Robenacoxib was present
in small but detectable levels in 5/6 cats in the treatment group.
Conclusions and clinical relevance- Administration of oral
robenacoxib did not significantly lessen experimentally-induced
anterior uveitis in normal cats, as assessed by fluorophotometry.
Low concentrations of aqueous humor
robenacoxib were detectable in
the majority of cats receiving the drug.
Advisors/Committee Members: Jessica Meekins.
Subjects/Keywords: Robenacoxib;
Blood-aqueous barrier;
Feline;
Fluorophotometry
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APA (6th Edition):
Sharpe, E. (2018). Effect of
oral administration of robenacoxib on experimentally-induced
anterior uveitis in normal cats: Effect of oral administration of robenacoxib on
inhibition of paracentesis-induced blood-aqueous barrier breakdown
in normal cats. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/39015
Chicago Manual of Style (16th Edition):
Sharpe, Emily. “Effect of
oral administration of robenacoxib on experimentally-induced
anterior uveitis in normal cats: Effect of oral administration of robenacoxib on
inhibition of paracentesis-induced blood-aqueous barrier breakdown
in normal cats.” 2018. Masters Thesis, Kansas State University. Accessed March 03, 2021.
http://hdl.handle.net/2097/39015.
MLA Handbook (7th Edition):
Sharpe, Emily. “Effect of
oral administration of robenacoxib on experimentally-induced
anterior uveitis in normal cats: Effect of oral administration of robenacoxib on
inhibition of paracentesis-induced blood-aqueous barrier breakdown
in normal cats.” 2018. Web. 03 Mar 2021.
Vancouver:
Sharpe E. Effect of
oral administration of robenacoxib on experimentally-induced
anterior uveitis in normal cats: Effect of oral administration of robenacoxib on
inhibition of paracentesis-induced blood-aqueous barrier breakdown
in normal cats. [Internet] [Masters thesis]. Kansas State University; 2018. [cited 2021 Mar 03].
Available from: http://hdl.handle.net/2097/39015.
Council of Science Editors:
Sharpe E. Effect of
oral administration of robenacoxib on experimentally-induced
anterior uveitis in normal cats: Effect of oral administration of robenacoxib on
inhibition of paracentesis-induced blood-aqueous barrier breakdown
in normal cats. [Masters Thesis]. Kansas State University; 2018. Available from: http://hdl.handle.net/2097/39015
Technical University of Lisbon
2.
Sousa, Sofia Palacim Terreiro de.
Utilização da escala multidimensional composta para avaliação de dor aguda pós-cirúrgica em gato para comparação de eficácia de três protocolos analgésicos no modelo cirúrgico de ovariohisterectomia eletiva felina.
Degree: 2014, Technical University of Lisbon
URL: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6529
► Dissertação de Mestrado Integrado em Medicina Veterinária
O alívio da dor pericirúrgica é uma temática essencial em Medicina Veterinária, não só pela promoção do bem-estar…
(more)
▼ Dissertação de Mestrado Integrado em Medicina Veterinária
O alívio da dor pericirúrgica é uma temática essencial em Medicina Veterinária, não só pela
promoção do bem-estar dos animais, como de uma melhor recuperação da anestesia. O
gato (Felis silvestris catus) é uma das espécies sobre as quais há um menor domínio do
reconhecimento e do controlo da dor. Recentemente, foi desenvolvida a “Escala
Multidimensional Composta Para Avaliação de Dor Aguda Pós-Cirúrgica em Gato”, que
constitui uma nova ferramenta no maneio da dor felina.
O presente estudo teve como objetivo a utilização da referida escala para comparar a
eficácia de três protocolos analgésicos, administrados em gatas saudáveis (n=30),
submetidas a ovariohisterectomia eletiva. Para efeitos de avaliação de dor peri-cirúrgica
consideraram-se as pontuações de dor no pré-cirúrgico (T0) e às 1h (T1), 2h (T2), 3h (T3),
4h (T4), 24h (T24) e 48h (T48) após a recuperação anestésica.
Os grupos de estudo – GR, GB e GRB – foram, respetivamente, pré-medicados com
robenacoxib (SC, 2mg/Kg) (n=10), buprenorfina (EV, 0.02mg/Kg) (n=10) e a combinação de
ambos os fármacos (n=10), 30-45 minutos antes da cirurgia. Durante o procedimento,
monitorizaram-se variáveis fisiológicas, como a pressão arterial sistólica, a frequência
cardíaca e a frequência respiratória. No pós-cirúrgico, pontuações de dor iguais ou
superiores a 8, com avaliação clínica concordante, remetiam para analgesia de resgate
(buprenorfina IM, 0,02mg/Kg). A análise estatística foi realizada com o software SAS 9.3
(SAS Institute, 2004), com recurso à análise de variância “One Way ANOVA”, ao teste de
comparação de médias, utilizando um teste t, e ao teste de qui-quadrado.
Os resultados revelaram pontuações de dor mais elevadas no grupo GB, seguido do GR e,
finalmente, do GRB. Quanto às analgesias de resgate, foram efetuadas em 2 gatas do grupo
GR, 3 do grupo GB e 0 do grupo GRB. Ainda que não se tivesse encontrado diferença
significativa entre os protocolos analgésicos, quando se analisaram as repetições das
analgesias de resgate, verificou-se maior exigência das mesmas no grupo GB. Da análise
das variáveis fisiológicas, retirou-se que apenas para a pressão arterial sistólica houve
diferenças significativas entre grupos.
Concluiu-se que a analgesia multimodal se mostrou mais eficiente, embora ambos os
protocolos com robenacoxib se tenham mostrado eficazes. Podemos também referir que a
presente escala de dor permitiu uma pontuação fidedigna e uma abordagem à dor póscirúrgica
do gato bem-sucedida.
ABSTRACT - Perioperative pain relief is a major subject in veterinary practice as it determines the level of
well being of the animals and provides a better anesthetic recovery. Nowadays there is still
lack of knowledge about pain detection and management in the domestic cat (Felis silvestris
catus). Recently a multidimensional composite scale for use in assessing acute
postoperative pain in cats was developed and represents a new tool for feline pain
management.
The purpose of the present study was to use this new pain…
Advisors/Committee Members: São Braz, Berta Maria Fernandes Ferreira, Vicente, Gonçalo Eduardo Vítor.
Subjects/Keywords: Gato; Ovariohisterectomia; Dor; Buprenorfina; Robenacoxib; Cat; Ovariohysterectomy; Pain; Buprenorphine
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APA (6th Edition):
Sousa, S. P. T. d. (2014). Utilização da escala multidimensional composta para avaliação de dor aguda pós-cirúrgica em gato para comparação de eficácia de três protocolos analgésicos no modelo cirúrgico de ovariohisterectomia eletiva felina. (Thesis). Technical University of Lisbon. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6529
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sousa, Sofia Palacim Terreiro de. “Utilização da escala multidimensional composta para avaliação de dor aguda pós-cirúrgica em gato para comparação de eficácia de três protocolos analgésicos no modelo cirúrgico de ovariohisterectomia eletiva felina.” 2014. Thesis, Technical University of Lisbon. Accessed March 03, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6529.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sousa, Sofia Palacim Terreiro de. “Utilização da escala multidimensional composta para avaliação de dor aguda pós-cirúrgica em gato para comparação de eficácia de três protocolos analgésicos no modelo cirúrgico de ovariohisterectomia eletiva felina.” 2014. Web. 03 Mar 2021.
Vancouver:
Sousa SPTd. Utilização da escala multidimensional composta para avaliação de dor aguda pós-cirúrgica em gato para comparação de eficácia de três protocolos analgésicos no modelo cirúrgico de ovariohisterectomia eletiva felina. [Internet] [Thesis]. Technical University of Lisbon; 2014. [cited 2021 Mar 03].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6529.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sousa SPTd. Utilização da escala multidimensional composta para avaliação de dor aguda pós-cirúrgica em gato para comparação de eficácia de três protocolos analgésicos no modelo cirúrgico de ovariohisterectomia eletiva felina. [Thesis]. Technical University of Lisbon; 2014. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6529
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universiteit Utrecht
3.
Hoeven, L.M.A. van der.
Comparison of Robenacoxib and carprofen in palliative management of cancer pain.
Degree: 2014, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/297059
► When dogs with cancer are no longer (or not at all) treated for their illness, a palliative treatment should be given to increase the wellbeing…
(more)
▼ When dogs with cancer are no longer (or not at all) treated for their illness, a palliative treatment should be given to increase the wellbeing of the dog. Dogs express pain in many different ways, sometimes by very subtle changes in behaviour. A brochure was created to inform owners about dogs that suffer from pain due to cancer and how to recognize this pain.
A blinded cross-over study was performed on 6 dogs with untreated tumors comparing
Robenacoxib and carporal as a palliative therapy. These two NSAIDs were compared using three forms (scoring pain, quality of life and adverse events), filled in weekly by the owners of the dogs. During 4 weeks every dog received either carprofen or
Robenacoxib, they then had a wash-out period of one day without pain medication. Subsequently the other medication (either
Robenacoxib or carprofen) was given during the next 4 weeks.
When looking at the interim results, using a paired samples t-test and an independent samples t-test no significant differences between the two medications were found. Further research by examining more dogs is necessary to obtain more data. It is important to see whether or not a significant difference could be acquired between the medications in the future.
Advisors/Committee Members: Nimwegen, S.A. van.
Subjects/Keywords: dogs; palliative treatment; cancer; Robenacoxib; carprofen; pain; NSAID
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APA ·
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APA (6th Edition):
Hoeven, L. M. A. v. d. (2014). Comparison of Robenacoxib and carprofen in palliative management of cancer pain. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/297059
Chicago Manual of Style (16th Edition):
Hoeven, L M A van der. “Comparison of Robenacoxib and carprofen in palliative management of cancer pain.” 2014. Masters Thesis, Universiteit Utrecht. Accessed March 03, 2021.
http://dspace.library.uu.nl:8080/handle/1874/297059.
MLA Handbook (7th Edition):
Hoeven, L M A van der. “Comparison of Robenacoxib and carprofen in palliative management of cancer pain.” 2014. Web. 03 Mar 2021.
Vancouver:
Hoeven LMAvd. Comparison of Robenacoxib and carprofen in palliative management of cancer pain. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2021 Mar 03].
Available from: http://dspace.library.uu.nl:8080/handle/1874/297059.
Council of Science Editors:
Hoeven LMAvd. Comparison of Robenacoxib and carprofen in palliative management of cancer pain. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/297059
Universiteit Utrecht
4.
Spierenburg, J.E.
Comparison of robenacoxib and carprofen in the palliative management of cancer pain.
Degree: 2013, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/287210
► Robenacoxib is a nonsteroidal anti-inflammatory drug and a selective cyclooxygenase (COX) -2 inhibitor, registered for treatment of osteoarthritis and post-operative pain in dogs. In a…
(more)
▼ Robenacoxib is a nonsteroidal anti-inflammatory drug and a selective cyclooxygenase (COX) -2 inhibitor, registered for treatment of osteoarthritis and post-operative pain in dogs. In a randomized cross over investigator-blinded trial with client-owned dogs diagnosed with a form of cancer, we compare treatment with
robenacoxib versus carprofen. Adverse effects (AEs), pain and Quality of Life (QoL) are assessed to determine which drug is the better choice in palliative management of the canine cancer patient. In the pain study, dogs were treated 28 days with one NSAID, had a wash out period of 1 day and were treated 28 days with the other NSAID. Physical examination and blood analysis were performed during a clinic visit every two weeks and every week forms assessing AEs, pain and QoL were filled out by the owner.
This research project report discusses results of the first four patients participating in this pain study. Results in this paper are blinded, because of continuation of the study.
The first patient showed no differences between treatments and only mild AEs and changes in scores, which were most likely caused by the effects of radiation therapy. The second dog survived 6 weeks and showed a difference in the two periods of the pain study, which may have been an idiosyncratic reaction of the dog to the NSAID secondly used. The third dog survived 3 weeks, thus was only treated with one NSAID; AEs and poor scores were most likely caused by progression of the tumour. The fourth dog showed no differences between treatments; AEs and changes in scores were most likely related to other causes than treatment.
Recruitment of patients and use of the forms are discussed and recommendations are given for the continuation of the pain study.
Advisors/Committee Members: Kirpensteijn, Prof. Dr. J.K..
Subjects/Keywords: robenacoxib; carprofen; NSAIDs; cancer; pain; pain management; palliative care; dogs; tumour
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APA (6th Edition):
Spierenburg, J. E. (2013). Comparison of robenacoxib and carprofen in the palliative management of cancer pain. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/287210
Chicago Manual of Style (16th Edition):
Spierenburg, J E. “Comparison of robenacoxib and carprofen in the palliative management of cancer pain.” 2013. Masters Thesis, Universiteit Utrecht. Accessed March 03, 2021.
http://dspace.library.uu.nl:8080/handle/1874/287210.
MLA Handbook (7th Edition):
Spierenburg, J E. “Comparison of robenacoxib and carprofen in the palliative management of cancer pain.” 2013. Web. 03 Mar 2021.
Vancouver:
Spierenburg JE. Comparison of robenacoxib and carprofen in the palliative management of cancer pain. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Mar 03].
Available from: http://dspace.library.uu.nl:8080/handle/1874/287210.
Council of Science Editors:
Spierenburg JE. Comparison of robenacoxib and carprofen in the palliative management of cancer pain. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/287210
5.
Paulo, Marta Niceia André.
Avaliação da dor na cirurgia e pós-operatório em cadelas submetidas a ovariohisterectomia eletiva.
Degree: 2014, Repositório Científico Lusófona
URL: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5768
► Nos últimos anos tem aumentado o interesse e as preocupações sobre a eficácia analgésica no período pós-operatório. A ovariohisterectomia é um exemplo de intervenção cirúrgica…
(more)
▼ Nos últimos anos tem aumentado o interesse e as preocupações sobre a eficácia analgésica no período pós-operatório. A ovariohisterectomia é um exemplo de intervenção cirúrgica que resulta em dor aguda moderada, constituindo um procedimento de rotina em cães que necessita de um tratamento analgésico adequado.
Atualmente, existem diversas escalas que auxiliam no reconhecimento e quantificação da dor em animais.
O presente estudo teve como objetivo avaliar a analgesia promovida pelo robenacoxib, um anti-inflamatório não esteróide, usado em veterinária para o tratamento da dor aguda e inflamação.
Para o efeito, foram utilizadas 11 cadelas saudáveis, sem raça definida, submetidas a ovariohisterectomia eletiva. Todos os animais foram pré-medicados com hidrocloreto de medetomidina e a anestesia induzida com cetamina. O isoflurano foi utilizado para manutenção da anestesia.
Durante o procedimento cirúrgico foram registados os valores da frequência cardíaca e respiratória, pressão arterial sistólica, pressão arterial média e pressão arterial diastólica para avaliar as alterações hemodinâmicas nos momentos cirúrgicos considerados mais dolorosos.
De forma a avaliar a dor pós-operatória, foram utilizadas a Escala de Dor da Universidade de Melbourne e a Escala Composta de Dor da Universidade de Glasgow (forma abreviada). Consideraram-se as pontuações de dor aos 30, 60, 120 180 e 240 minutos após a recuperação anestésica. Em relação à avaliação da dor, observou-se que não existiram sinais marcados de dor e de desconforto, tanto em animais com idade inferior a 1 ano como os com idade igual ou superior a 1 ano.
Com base nos resultados obtidos, pode concluir-se que a analgesia promovida pelo robenacoxib foi satisfatória, o que demonstra a eficácia deste fármaco no tratamento da dor pós-operatória em cadelas submetidas a ovariohisterectomia eletiva.
During the last years, the interest and concerning on the analgesic efficacy in the post-operative period have increased. The ovariohysterectomy is an example of a surgery that results in moderate acute pain and constitutes a routine procedure in dogs, in need of an adjusted analgesic treatment.
Nowadays there are several scales that help recognizing and quantifying pain in animals.
The aim of this study consists in evaluating the analgesia promoted by the robenacoxib, a non steroidal anti-inflammatory, used in veterinary practice to treat acute pain and inflammation.
For this purpose, eleven healthy female mixed breed dogs were submitted to elective ovariohysterectomy. All animals were premedicated with medetomidine hydrochloride and anesthesia was induced with ketamine. Isoflurane was also used to maintain anesthesia.
The values of cardiac and respiratory frequencies, systolic arterial pressure, average arterial pressure and diastolic arterial pressure were registered during the surgical procedure to evaluate the hemodynamic changes in the most painful surgical moments. To evaluate the effects of postoperative analgesia were used the pain scale from the University of Melbourne and the…
Advisors/Committee Members: Requicha, João Filipe, orient..
Subjects/Keywords: VETERINÁRIA; CÃES; OVARIOHISTERECTOMIA; CANÍDEOS; AVALIAÇÃO DA DOR; CANIDS; DOGS; OVARIOHYSTERECTOMY; PAIN EVALUATION; ROBENACOXIB; ROBENACOXIB; MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA; ANALGESIA; MEDICINA VETERINÁRIA; VETERINARY MEDICINE
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APA ·
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APA (6th Edition):
Paulo, M. N. A. (2014). Avaliação da dor na cirurgia e pós-operatório em cadelas submetidas a ovariohisterectomia eletiva. (Thesis). Repositório Científico Lusófona. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5768
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Paulo, Marta Niceia André. “Avaliação da dor na cirurgia e pós-operatório em cadelas submetidas a ovariohisterectomia eletiva.” 2014. Thesis, Repositório Científico Lusófona. Accessed March 03, 2021.
https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5768.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Paulo, Marta Niceia André. “Avaliação da dor na cirurgia e pós-operatório em cadelas submetidas a ovariohisterectomia eletiva.” 2014. Web. 03 Mar 2021.
Vancouver:
Paulo MNA. Avaliação da dor na cirurgia e pós-operatório em cadelas submetidas a ovariohisterectomia eletiva. [Internet] [Thesis]. Repositório Científico Lusófona; 2014. [cited 2021 Mar 03].
Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5768.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Paulo MNA. Avaliação da dor na cirurgia e pós-operatório em cadelas submetidas a ovariohisterectomia eletiva. [Thesis]. Repositório Científico Lusófona; 2014. Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5768
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Nunes, Diogo João da Silva Alves Grosso.
Avaliação do efeito analgésico do robenacoxib comparativamente com o meloxican no maneio da dor em cadelas submetidas a ovariohisterectomia.
Degree: 2013, Repositório Científico Lusófona
URL: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5748
► Os anti-inflamatórios não esteróides constituem uma parte integrante no controlo da dor peri-operatória em casos de cirurgia de tecidos moles. O objectivo deste estudo consistiu…
(more)
▼ Os anti-inflamatórios não esteróides constituem uma parte integrante no controlo da dor peri-operatória em casos de cirurgia de tecidos moles.
O objectivo deste estudo consistiu na comparação de dois anti-inflamatórios não esteroides, o robenocoxib e o meloxican na analgesia peri-operatória em cadelas submetidas a ovario-histerectomia.
Vinte cadelas submetidas a ovariohisterectomia eletiva, sem doenças concomitantes, com média de idades de 2,67 anos e média de peso de 14,45 kg, foram incluídas no estudo e separadas de forma aleatória em dois grupos. O primeiro grupo recebeu meloxicam na dose de 0,2 mg/kg e o segundo grupo recebeu robenacoxib na dose de 0,2 mg/kg. Os fármacos foram incluídos nos grupos enquanto parte integrante de um protocolo analgésico multimodal.
A avaliação da dor foi realizada intra-operativamente através do registo de parâmetros intracirurgicos frequência cardíaca, frequência respiratória e nível de consumo de isoflurano. A avaliação da dor foi realizada pós operatoriamente com recurso à escala de dor visual modificada da Universidade de Colorado. A avaliação pós cirúrgica foi realizada às 0H e 2H.
Não foram identificadas diferenças com significado estatístico em qualquer momento intra e pós cirúrgico para cada um dos parâmetros registados. Os resultados para os momentos 0 e 2 horas pós cirúrgicos para o grupo tratado com robenocoxib foi respectivamente de 7,3 e 4,1. Para o meloxican foi de 8,1 e 4 respectivamente. Não foram verificadas diferenças com significado estatístico entre os dois grupos.
Os anti-inflamatórios meloxican e robenocoxib possuem uma eficácia analgésica semelhante.
Nonsteroidal anti-inflammatory drugs are an important part in the control of perioperative pain in cases of soft tissue surgery.
The aim of this study was to compare two anti-inflammatory drugs, the robenocoxib and meloxicam in perioperative analgesia in dogs undergoing ovarian hysterectomy.
Twenty bitches undergoing elective ovariohysterectomy without concomitant diseases, with an average age of 2.67 years and an average weight of 14.45 kg were included in the study and randomly separated into two groups. The first group received meloxicam in a dose of 0.2 mg / kg, the second group received robenacoxib in a dose of 0.2 mg/kg. The drugs were included in the groups as part of a multimodal analgesic protocol.
Pain assessment was performed intra-operatively by recording the following parameters: intraoperative heart rate, respiratory rate and level of consumption of isoflurane. Pain assessment was performed post operatively using the modified visual pain scale from the University of Colorado. A post surgical evaluation was performed at 0H and 2H.
No statistically significant differences were at any time register during and after surgery for each parameter recorded. Results for times 0 and 2 hours post-surgery for the treated group with robenocoxib were 7.3 and 4.1 respectively. For meloxicam group was 8.1 and 4 respectively. There were no differences with statistical significance between the two groups.
Robenacoxib…
Advisors/Committee Members: Cardoso, Nuno Gonçalo Ferreira, orient..
Subjects/Keywords: VETERINÁRIA; CÃES; DOGS; ANTI-INFLAMATÓRIOS; ROBENACOXIB; OVARIOHISTERECTOMIA; ANTI-INFLAMMATORY DRUGS; ROBENACOXIB; OVARIOHYSTERECTOMY; MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA; CANÍDEOS; CANIDS; MELOXICAM; MEDICINA VETERINÁRIA; VETERINARY MEDICINE
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APA (6th Edition):
Nunes, D. J. d. S. A. G. (2013). Avaliação do efeito analgésico do robenacoxib comparativamente com o meloxican no maneio da dor em cadelas submetidas a ovariohisterectomia. (Thesis). Repositório Científico Lusófona. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5748
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nunes, Diogo João da Silva Alves Grosso. “Avaliação do efeito analgésico do robenacoxib comparativamente com o meloxican no maneio da dor em cadelas submetidas a ovariohisterectomia.” 2013. Thesis, Repositório Científico Lusófona. Accessed March 03, 2021.
https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5748.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nunes, Diogo João da Silva Alves Grosso. “Avaliação do efeito analgésico do robenacoxib comparativamente com o meloxican no maneio da dor em cadelas submetidas a ovariohisterectomia.” 2013. Web. 03 Mar 2021.
Vancouver:
Nunes DJdSAG. Avaliação do efeito analgésico do robenacoxib comparativamente com o meloxican no maneio da dor em cadelas submetidas a ovariohisterectomia. [Internet] [Thesis]. Repositório Científico Lusófona; 2013. [cited 2021 Mar 03].
Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5748.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nunes DJdSAG. Avaliação do efeito analgésico do robenacoxib comparativamente com o meloxican no maneio da dor em cadelas submetidas a ovariohisterectomia. [Thesis]. Repositório Científico Lusófona; 2013. Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5748
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
. 
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