subject:(Retina)

University of Tasmania

1. Buttery, Robert Gordon. Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels.

Degree: 1990, University of Tasmania

URL: https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf

► The physical requirements necessary for the perception of light have produced peculiar adaptions to the way in which the eye is nourished. In many mammals… (more)

▼ The physical requirements necessary for the perception of light have produced peculiar adaptions to the way in which the eye is nourished. In many mammals there is a dual blood supply to the retina derived from both choroidal and intraretinal circulations. Interestingly, some species have only a choroidal blood supply. This study has addressed the coping strategies of those retinae which lack intraretinal blood vessels. Placental guinea pigs and diprotodont marsupial brushtail possums and sugar gliders, all of which lack retinal circulation (avascular retinae) have been compared with placental rats and polyprotodont marsupial quolls, Virginia opossums and Tasmanian devils, all of which possess intraretinal blood vessels (vascular retinae). Functional angiographic study has documented vascular patterns and demonstrated the close arteriovenous pairing within the polyprotodont marsupial retina. Avascular retinae are thinner than their vascular counterparts. The difference is not great (170Am versus 220gm): The limitation in thickness is borne by most retinal laminae but more so by those layers furthest from the choroidal supply. Morphological analysis suggests that spatial visual acuity is comparable in vascular and avascular species. Corrosion casting and microscopy of the ocular vasculature has shown that the choroid of the avascular species examined has no obvious morphological specialisations which might offset the lack of retinal vessels. However, the metabolic pathways within the inner layers of avascular retinae are markedly different, with limited oxidative metabolism as indicated by the activity of the mitochondrial enzyme, cytochrome oxidase. However, ATPase activity, as a measure of overall energy consumption, is known to be high within the inner layers of the avascular guinea pig retina (Ueno et al. 1981). This suggests that low cytochrome oxidase activity need not mean limited functional metabolic capacity. As a morphological accompaniment of oxidative activity, ultrastructural analysis would suggest that mitochondrial numbers may be reduced within the inner retinal layers of avascular retinae when compared with similar regions in vascular retinae. Central to these observations is the clinical question of whether the human retina can mimic the coping strategies of avascular retinae following pathological disruption of its intrinsic vasculature.

Subjects/Keywords: Retina; Retina

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APA (6^th Edition):

Buttery, R. G. (1990). Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Buttery, Robert Gordon. “Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels.” 1990. Thesis, University of Tasmania. Accessed March 07, 2021. https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Buttery, Robert Gordon. “Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels.” 1990. Web. 07 Mar 2021.

Vancouver:

Buttery RG. Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels. [Internet] [Thesis]. University of Tasmania; 1990. [cited 2021 Mar 07]. Available from: https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Buttery RG. Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels. [Thesis]. University of Tasmania; 1990. Available from: https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hawaii

2. Kato, Susumu. Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus.

Degree: 2015, University of Hawaii

URL: http://hdl.handle.net/10125/36006

►

Typescript.

Bibliography: leaves 63-67.

v, 67 leaves mounted illustrations (part color) tables

This thesis is concerned with the retinal histology of two species of sharks… (more)

Subjects/Keywords: Sharks; Retina; Retina; Sharks

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APA (6^th Edition):

Kato, S. (2015). Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus. (Thesis). University of Hawaii. Retrieved from http://hdl.handle.net/10125/36006

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kato, Susumu. “Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus.” 2015. Thesis, University of Hawaii. Accessed March 07, 2021. http://hdl.handle.net/10125/36006.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kato, Susumu. “Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus.” 2015. Web. 07 Mar 2021.

Vancouver:

Kato S. Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus. [Internet] [Thesis]. University of Hawaii; 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10125/36006.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kato S. Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus. [Thesis]. University of Hawaii; 2015. Available from: http://hdl.handle.net/10125/36006

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. González del Pozo, María. Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados.

Degree: 2014, Universidad de Sevilla

URL: http://hdl.handle.net/11441/23909

► Diagnosticar genéticamente a las familias afectas de alguna de las distrofias hereditarias de retina (DHR) es, desde el punto de vista del genetista, una tarea… (more)

Subjects/Keywords: Retina; Ojo

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APA (6^th Edition):

González del Pozo, M. (2014). Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados. (Thesis). Universidad de Sevilla. Retrieved from http://hdl.handle.net/11441/23909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

González del Pozo, María. “Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados.” 2014. Thesis, Universidad de Sevilla. Accessed March 07, 2021. http://hdl.handle.net/11441/23909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

González del Pozo, María. “Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados.” 2014. Web. 07 Mar 2021.

Vancouver:

González del Pozo M. Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados. [Internet] [Thesis]. Universidad de Sevilla; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/11441/23909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

González del Pozo M. Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados. [Thesis]. Universidad de Sevilla; 2014. Available from: http://hdl.handle.net/11441/23909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Hernandez Matas, Carlos. Retinal image registration through 3D eye modelling and pose estimation.

Degree: 2017, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/42160

►

The in vivo assessment of small vessels can promote accurate diagnosis and progression monitoring of diseases related to vasculopathy, such as hypertension and diabetes. Given… (more)

▼

The in vivo assessment of small vessels can promote accurate diagnosis and progression monitoring of diseases related to vasculopathy, such as hypertension and diabetes. Given that the human eye retina contains small vessels that can be directly imaged via fundoscopy, the analysis of retinal structures becomes very important for non-invasive approaches. This is also important for the diagnosis of illnesses that affect eyesight, such as macular edema, age-related macular degeneration or glaucoma. This analysis can be greatly facilitated by accurate retinal image registration.Image registration is applied upon a pair of images, the reference and the test image. The goal is to warp the test image so that it images retinal points at the same 2D locations as the reference image. This is a challenging task, mainly for two reasons. The first is related to the perspective distortions due to the curved shape of the retina and change of the camera pose relative to the eye between image acquisitions. The second relates to potential changes in the retina that occur due to retinopathy between temporally distant image acquisitions. In addition, the nature of the application demands for high registration accuracy. Registration methods may benefit from knowledge of the type of images to be registered. In this work, we proposed a registration framework that simultaneously estimates the relative pose of the cameras that acquired the retinal images as well as the shape and the pose of the eye. The proposed framework is evaluated quantitatively and is shown to outperform state-of-the-art methods. In the context of this work, we also developed a set of tools for generating realistic 3D eye models. These tools were used to render synthetic retinal image pairs, utilized for testing and evaluating the proposed registration approach. Additionally, FIRE, a dataset comprised of pairs of real retinal images has been compiled and made publicly available. FIRE consists of three types of images, each one covering different challenges in retinal image registration. To enable the experimental, quantitative evaluation of the accuracy of a registration method, FIRE is annotated with ground truth point correspondences. In this work, we also explored the suitability of the proposed registration framework for applications such as longitudinal studies, image mosaicing and super resolution. Additionally, the fitness of the framework for performing eye shape estimation is studied. Pertinent experiments show encouraging results as well as ample room for further improvement.

Η μελέτη των λεπτών αιμοφόρων αγγείων μπορεί να βοηθήσει την ακριβή διάγνωση και την παρακολούθηση νόσων που σχετίζονται με αγγειοπάθεια, όπως η υπέρταση και ο διαβήτης. Η ευκολία απεικόνισης τέτοιων αγγείων στον αμφιβληστροειδή χιτώνα μέσω βυθοσκόπισης καθιστά την ανάλυση των δομικών χαρακτηριστικών του ιδιαίτερα σημαντική. Η ανάλυση αυτή είναι επίσης σημαντική για τη διάγνωση ασθενειών που επηρεάζουν την όραση, όπως το οίδημα της ωχράς κηλίδας, η ηλικιακή εκφύλιση της ωχράς κηλίδας…

Subjects/Keywords: Αντιστοίχιση; Retina

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APA (6^th Edition):

Hernandez Matas, C. (2017). Retinal image registration through 3D eye modelling and pose estimation. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/42160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hernandez Matas, Carlos. “Retinal image registration through 3D eye modelling and pose estimation.” 2017. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed March 07, 2021. http://hdl.handle.net/10442/hedi/42160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hernandez Matas, Carlos. “Retinal image registration through 3D eye modelling and pose estimation.” 2017. Web. 07 Mar 2021.

Vancouver:

Hernandez Matas C. Retinal image registration through 3D eye modelling and pose estimation. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2017. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10442/hedi/42160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hernandez Matas C. Retinal image registration through 3D eye modelling and pose estimation. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2017. Available from: http://hdl.handle.net/10442/hedi/42160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

5. Pastor Idoate, Salvador. Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4.

Degree: 2015, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/16655

► Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreoretinopatía proliferante. Tesis elaborada bajo la modalidad… (more)

Subjects/Keywords: Retina-Desprendimiento

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APA (6^th Edition):

Pastor Idoate, S. (2015). Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/16655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pastor Idoate, Salvador. “Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4.” 2015. Thesis, Universidad de Valladolid. Accessed March 07, 2021. http://uvadoc.uva.es/handle/10324/16655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pastor Idoate, Salvador. “Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4.” 2015. Web. 07 Mar 2021.

Vancouver:

Pastor Idoate S. Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4. [Internet] [Thesis]. Universidad de Valladolid; 2015. [cited 2021 Mar 07]. Available from: http://uvadoc.uva.es/handle/10324/16655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pastor Idoate S. Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4. [Thesis]. Universidad de Valladolid; 2015. Available from: http://uvadoc.uva.es/handle/10324/16655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

6. Sosula, Leo. The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer.

Degree: 1969, University of Adelaide

URL: http://hdl.handle.net/2440/20416

Subjects/Keywords: Retina.

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APA (6^th Edition):

Sosula, L. (1969). The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/20416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sosula, Leo. “The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer.” 1969. Thesis, University of Adelaide. Accessed March 07, 2021. http://hdl.handle.net/2440/20416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sosula, Leo. “The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer.” 1969. Web. 07 Mar 2021.

Vancouver:

Sosula L. The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer. [Internet] [Thesis]. University of Adelaide; 1969. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2440/20416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sosula L. The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer. [Thesis]. University of Adelaide; 1969. Available from: http://hdl.handle.net/2440/20416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

7. Felder, Anthony E. Multi-modal Imaging of Retinal Oxygenation.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21910

► The retina is a light-sensitive tissue located at the back of the eye and plays a key role in vision. To maintain visual function, the… (more)

▼ The retina is a light-sensitive tissue located at the back of the eye and plays a key role in vision. To maintain visual function, the amount of oxygen in the retina (retinal oxygenation) is highly regulated under normal physiological conditions. However, alteration of retinal oxygenation is implicated in common vision-threatening retinal diseases including diabetic retinopathy, glaucoma and macular degeneration. Additionally, retinal oxygenation can be perturbed and characterized by the physiological challenge of diffuse light flicker stimulation (DLFS). Therefore, research that characterizes retinal oxygenation and its response to DLFS in health and disease is essential. To date, available techniques for the direct assessment of retinal oxygenation are invasive and cannot be used in humans. Therefore, markers of retinal oxygenation in humans – retinal vessel diameter (D), retinal vessel oxygen saturation of hemoglobin (SO2) and the inner retinal oxygen extraction fraction (OEF) – are measured non-invasively instead. However, in animals, retinal oxygenation may be directly assessed by measurement of retinal tissue oxygen tension (tPO2). This thesis describes novel techniques to assess retinal oxygenation markers in humans and tPO2 in rats. An optical imaging system for the non-invasive measurement of retinal oxygenation markers in humans was developed and then applied to assess the effects of diabetic retinopathy disease stage and DLFS on markers. Additionally, the system was modified to measure and mathematically model the temporal dynamic responses of retinal oxygenation markers to DLFS. To address limitations in subjects’ fixation during the assessment of these temporal dynamics, a system for real-time image stabilization was developed. Finally, a technique for the three-dimensional assessment of retinal tPO2 in rats was developed, permitting the evaluation and assessment of multifocal retinal oxygenation abnormalities. Advisors/Committee Members: Shahidi, Mahnaz (advisor), Blair, Norman P (committee member), Hetling, John R (committee member), Kotche, Miiri A (committee member), Royston, Thomas J (committee member), Shahidi, Mahnaz (chair).

Subjects/Keywords: retina; oxygenation

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APA (6^th Edition):

Felder, A. E. (2017). Multi-modal Imaging of Retinal Oxygenation. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Felder, Anthony E. “Multi-modal Imaging of Retinal Oxygenation.” 2017. Thesis, University of Illinois – Chicago. Accessed March 07, 2021. http://hdl.handle.net/10027/21910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Felder, Anthony E. “Multi-modal Imaging of Retinal Oxygenation.” 2017. Web. 07 Mar 2021.

Vancouver:

Felder AE. Multi-modal Imaging of Retinal Oxygenation. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10027/21910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Felder AE. Multi-modal Imaging of Retinal Oxygenation. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/21910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

8. Ronellenfitch, Kara. Investigating the possibility of Notch signalling in the adult retina.

Degree: Dept. of Biology, 2013, University of Victoria

URL: http://hdl.handle.net/1828/4858

► The Notch signalling pathway is a highly conserved cell-to-cell signalling pathway involved in developmental cell fate determination in all metazons. When Notch is signalling, differentiation… (more)

▼ The Notch signalling pathway is a highly conserved cell-to-cell signalling pathway involved in developmental cell fate determination in all metazons. When Notch is signalling, differentiation is inhibited and a progenitor-like state is favoured. This signalling pathway has been implicated in the developing retina, where the inhibition of Notch has been shown to skew the proportion of different retinal neuronal cell types. Although functional knockout studies have allowed us to characterize some of the roles of Notch in the retina, low protein levels have made it difficult to characterize the location of Notch receptors and ligands in neuronal tissue. Here we sought to characterize the localization of the Notch signalling pathway components in both the developing and the adult mouse retina. Using RT-PCR we were able to show the presence of mRNA for Notch receptors, ligands, and DNA binding cofactors for the Notch intracellular domain, CBF1, throughout postnatal development as well as in the adult retina. In situ hybridization confirmed the presence of Notch1, Notch2, and CBF1 mRNA in the embryonic (E14.5) and early postnatal (P1.5) retina similar to what has been reported in earlier studies, but in the adult retina (P40), levels were below detection. To further explore the role of Notch in the adult retina we used two transgenic mouse reporter models in which a Notch responsive element directs the expression of EGFP or Venus. In the adult retina of the NTR line (Tg(Cp-EGFP)25Gaia/J) reporter expression was detected in rod ON and cone type 2 OFF bipolar cells, as well as in a subset of both amacrine and ganglion cells. In the CBFRE:H2B-Venus line adult reporter expression was detected in photoreceptors, and a large proportion of both amacrine and ganglion cells. Together this data supports the conclusion that Notch is expressed and actively signalling in the retina throughout development and possibly in the adult retina, although below levels of in situ hybridization detection. These results represent the possibility of a previously unknown role for Notch in the adult retina. Advisors/Committee Members: Chow, Robert Lewis (supervisor).

Subjects/Keywords: retina; notch

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APA (6^th Edition):

Ronellenfitch, K. (2013). Investigating the possibility of Notch signalling in the adult retina. (Masters Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/4858

Chicago Manual of Style (16^th Edition):

Ronellenfitch, Kara. “Investigating the possibility of Notch signalling in the adult retina.” 2013. Masters Thesis, University of Victoria. Accessed March 07, 2021. http://hdl.handle.net/1828/4858.

MLA Handbook (7^th Edition):

Ronellenfitch, Kara. “Investigating the possibility of Notch signalling in the adult retina.” 2013. Web. 07 Mar 2021.

Vancouver:

Ronellenfitch K. Investigating the possibility of Notch signalling in the adult retina. [Internet] [Masters thesis]. University of Victoria; 2013. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1828/4858.

Council of Science Editors:

Ronellenfitch K. Investigating the possibility of Notch signalling in the adult retina. [Masters Thesis]. University of Victoria; 2013. Available from: http://hdl.handle.net/1828/4858

Michigan State University

9. Kobamoto, Naotada, 1940-. The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes.

Degree: PhD, 1970, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:35281

Subjects/Keywords: Retina

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APA (6^th Edition):

Kobamoto, Naotada, 1. (1970). The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:35281

Chicago Manual of Style (16^th Edition):

Kobamoto, Naotada, 1940-. “The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes.” 1970. Doctoral Dissertation, Michigan State University. Accessed March 07, 2021. http://etd.lib.msu.edu/islandora/object/etd:35281.

MLA Handbook (7^th Edition):

Kobamoto, Naotada, 1940-. “The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes.” 1970. Web. 07 Mar 2021.

Vancouver:

Kobamoto, Naotada 1. The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes. [Internet] [Doctoral dissertation]. Michigan State University; 1970. [cited 2021 Mar 07]. Available from: http://etd.lib.msu.edu/islandora/object/etd:35281.

Council of Science Editors:

Kobamoto, Naotada 1. The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes. [Doctoral Dissertation]. Michigan State University; 1970. Available from: http://etd.lib.msu.edu/islandora/object/etd:35281

Michigan State University

10. Haines, Richard Foster. A study of retinal intensity gradients.

Degree: PhD, Department of Psychology, 1964, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:40718

Subjects/Keywords: Retina

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APA (6^th Edition):

Haines, R. F. (1964). A study of retinal intensity gradients. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:40718

Chicago Manual of Style (16^th Edition):

Haines, Richard Foster. “A study of retinal intensity gradients.” 1964. Doctoral Dissertation, Michigan State University. Accessed March 07, 2021. http://etd.lib.msu.edu/islandora/object/etd:40718.

MLA Handbook (7^th Edition):

Haines, Richard Foster. “A study of retinal intensity gradients.” 1964. Web. 07 Mar 2021.

Vancouver:

Haines RF. A study of retinal intensity gradients. [Internet] [Doctoral dissertation]. Michigan State University; 1964. [cited 2021 Mar 07]. Available from: http://etd.lib.msu.edu/islandora/object/etd:40718.

Council of Science Editors:

Haines RF. A study of retinal intensity gradients. [Doctoral Dissertation]. Michigan State University; 1964. Available from: http://etd.lib.msu.edu/islandora/object/etd:40718

University of Notre Dame

11. Sean C. Kassen. Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>.

Degree: Biological Sciences, 2008, University of Notre Dame

URL: https://curate.nd.edu/show/qn59q239w5t

► The zebrafish retina is an excellent model to study the molecular basis of neural cell regeneration. Dark-treated albino zebrafish exposed to intense light undergo… (more)

▼ The zebrafish retina is an excellent model to study the molecular basis of neural cell regeneration. Dark-treated albino zebrafish exposed to intense light undergo rod and cone photoreceptor apoptosis, which triggers MÌÄå_ller glia proliferation and the generation of neuronal progenitor cells. Next, multiple neuronal progenitor cells will either migrate to the outer nuclear layer and regenerate lost rods and cones or will remain in the inner nuclear layer to repopulate lost Müller glia. To identify candidate genes encode critical proteins required during photoreceptor regeneration, I performed a time course microarray of six time points representing different cellular events during the regeneration response. qRT-PCR verified the expression profiles for selected genes in the microarray data set. To examine genes involved in Müller glial cell proliferation and progenitor cell differentiation, I performed temporal and functional gene cluster analysis. I selected three genes for further analysis: i) Stat3, which functions through the Jak/Stat pathway, ii) CNTF, a growth factor that is known to activate the Jak/Stat pathway, and iii) Olig2, a transcription factor that regulates neuron and glial cell fates. Immunoblots verified increased total and activated Stat3 protein expression during the time course. Immunolocalization demonstrated increased Stat3 expression in Müller glial cells by 31 hours, and some Stat3-positive Müller glial cells expressed PCNA. To determine protein function during regeneration, I electroporated morpholinos into the adult retina to knockdown expression of target proteins. Stat3 knockdown significantly reduced the number of PCNA-labeled Müller glial cells during the light treatment, which demonstrated a role for Stat3 during light-induced retinal regeneration. Intravitreal CNTF injections suppressed light-induced photoreceptor apoptosis. Injection of CNTF into the undamaged zebrafish eye induced Stat3 expression in Müller cells, and Müller glia proliferation. However, knockdown of Stat3 in the CNTF-injected undamaged eye still induced Müller glia proliferation, which demonstrates CNTF’s mode of action is independent of Stat3. These data suggest Stat3 and CNTF possess independent roles in the damaged and undamaged zebrafish retina. Olig2 was expressed in dedifferentiated Müller glia and INL neuronal progenitor cells between 51 and 96 hrs of light treatment. Electroporation of anti-olig2 morpholinos knocked down Olig2 during zebrafish retinal regeneration. However, knockdown of Olig2 did not effect either cell proliferation, migration, or photoreceptor cell differentiation. Advisors/Committee Members: David Hyde, Committee Chair, Kevin Vaughan, Committee Member, Joe OTousa, Committee Member, Lei Li, Committee Member.

Subjects/Keywords: retina

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APA (6^th Edition):

Kassen, S. C. (2008). Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>. (Thesis). University of Notre Dame. Retrieved from https://curate.nd.edu/show/qn59q239w5t

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kassen, Sean C.. “Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>.” 2008. Thesis, University of Notre Dame. Accessed March 07, 2021. https://curate.nd.edu/show/qn59q239w5t.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kassen, Sean C.. “Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>.” 2008. Web. 07 Mar 2021.

Vancouver:

Kassen SC. Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>. [Internet] [Thesis]. University of Notre Dame; 2008. [cited 2021 Mar 07]. Available from: https://curate.nd.edu/show/qn59q239w5t.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kassen SC. Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>. [Thesis]. University of Notre Dame; 2008. Available from: https://curate.nd.edu/show/qn59q239w5t

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

12. -8288-8714. Factors Regulating Initiation of Retina Regeneration in Zebrafish.

Degree: PhD, Biological Sciences, 2020, Vanderbilt University

URL: http://hdl.handle.net/1803/15933

► Retina regeneration has been proposed as a potential treatment for retinal diseases. Unlike mammals, zebrafish are capable of naturally regenerating the retina in response to… (more)

Subjects/Keywords: retina; regeneration

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APA (6^th Edition):

-8288-8714. (2020). Factors Regulating Initiation of Retina Regeneration in Zebrafish. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15933

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-8288-8714. “Factors Regulating Initiation of Retina Regeneration in Zebrafish.” 2020. Doctoral Dissertation, Vanderbilt University. Accessed March 07, 2021. http://hdl.handle.net/1803/15933.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-8288-8714. “Factors Regulating Initiation of Retina Regeneration in Zebrafish.” 2020. Web. 07 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-8288-8714. Factors Regulating Initiation of Retina Regeneration in Zebrafish. [Internet] [Doctoral dissertation]. Vanderbilt University; 2020. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1803/15933.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-8288-8714. Factors Regulating Initiation of Retina Regeneration in Zebrafish. [Doctoral Dissertation]. Vanderbilt University; 2020. Available from: http://hdl.handle.net/1803/15933

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Universidade Estadual de Campinas

13. Duarte, Mario Antonio. Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves.

Degree: 2000, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252

Subjects/Keywords: Retina

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APA (6^th Edition):

Duarte, M. A. (2000). Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Duarte, Mario Antonio. “Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves.” 2000. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Duarte, Mario Antonio. “Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves.” 2000. Web. 07 Mar 2021.

Vancouver:

Duarte MA. Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves. [Internet] [Thesis]. Universidade Estadual de Campinas; 2000. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Duarte MA. Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves. [Thesis]. Universidade Estadual de Campinas; 2000. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

14. Arthur, Angélica Moises, 1979-. Contribuições para medidas de eficiência de protocolos fisioterapêuticos e exercícios físico e diagnóstico automático de patologias usando imagens de alta resolução da retina humana: Contributions to physical therapy protocols efficiency measures and physical exercise and pathologies automatic diagnosis using high definition images of the human retina.

Degree: 2016, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330555

► Abstract: This thesis aims to propose methodologies for automatic diagnosis or propensity to disease and methodologies to measure the effectiveness of treatments and exercise using… (more)

▼ Abstract: This thesis aims to propose methodologies for automatic diagnosis or propensity to disease and methodologies to measure the effectiveness of treatments and exercise using high-resolution images of the human retina. The images used in this work were taken by a retinographer called Retinal Function Imager (RFI), acquired through a thematic research project FAPESP MHR (Medical School) in partnership with the FEEC (School of Electrical and Computer Engineering), both from Unicamp. The microvasculature of the human retina has a unique and important feature of allowing the visualization of the human circulation directly, non-invasively and in vivo promptly photographed and subjected to digital image analysis. The RFI used here allows viewing of previously inaccessible structures. We investigated initially from a group of athletes, the ratio of physical exercise with the flow rate of the retinal microcirculation and intraocular pressure. Comparing before and after exercise, there was an average 40% increase in the venous flow rate, and a 27.2% decrease intraocular pressure. Next, we investigated the blood flow velocity in tetraplegic patients undergoing treatment by electrostimulation, comparing with the average flow velocity obtained by healthy patients. The blood flow rate in the tetraplegic was about 28% lower than the average healthy patients. An investigation of the individual flow rates was also performed from the pathological features and treatment of patients. These results may be relevant in the proposed new protocols and outcome measures of treatment in patients with glaucoma and spinal cord injuries, respectively. Finally, an automatic method is proposed to identify and quantify the region of the foveal avascular zone of the retina. For this, we used alternating sequential morphological filter, followed by the watershed transformed with markers. Using a database of sequences 38 of 20 volunteers, the segmentation was successful in all cases, from the comparison of manual selection experts. Using as a descriptor invariant moments of Hu and as the KNN classifier (K-Nearest Neighbor) was possible to differentiate between healthy and diabetic patients in 78% of cases. This can be an important tool for the early diagnosis of diseases. The results show that the information of the topology and behavior of retinal flows can play an important role in helping health professionals in different condition levels, from prevention and propensity to disease even to measure the evolution of a treatment Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Iano, Yuzo, 1950- (advisor), Universidade Estadual de Campinas. Faculdade de Engenharia Elétrica e de Computação (institution), Programa de Pós-Graduação em Engenharia Elétrica (nameofprogram), Pelaes, Evaldo Gonçalves (committee member), Higa, Rogerio Seiji (committee member), Martini, Luiz César (committee member), Sunemi, Mariana Maia de Oliveira (committee member).

Subjects/Keywords: Processamento de imagens; Retina; Image processing; Retina

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APA (6^th Edition):

Arthur, Angélica Moises, 1. (2016). Contribuições para medidas de eficiência de protocolos fisioterapêuticos e exercícios físico e diagnóstico automático de patologias usando imagens de alta resolução da retina humana: Contributions to physical therapy protocols efficiency measures and physical exercise and pathologies automatic diagnosis using high definition images of the human retina. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/330555

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arthur, Angélica Moises, 1979-. “Contribuições para medidas de eficiência de protocolos fisioterapêuticos e exercícios físico e diagnóstico automático de patologias usando imagens de alta resolução da retina humana: Contributions to physical therapy protocols efficiency measures and physical exercise and pathologies automatic diagnosis using high definition images of the human retina.” 2016. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/330555.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arthur, Angélica Moises, 1979-. “Contribuições para medidas de eficiência de protocolos fisioterapêuticos e exercícios físico e diagnóstico automático de patologias usando imagens de alta resolução da retina humana: Contributions to physical therapy protocols efficiency measures and physical exercise and pathologies automatic diagnosis using high definition images of the human retina.” 2016. Web. 07 Mar 2021.

Vancouver:

Arthur, Angélica Moises 1. Contribuições para medidas de eficiência de protocolos fisioterapêuticos e exercícios físico e diagnóstico automático de patologias usando imagens de alta resolução da retina humana: Contributions to physical therapy protocols efficiency measures and physical exercise and pathologies automatic diagnosis using high definition images of the human retina. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330555.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arthur, Angélica Moises 1. Contribuições para medidas de eficiência de protocolos fisioterapêuticos e exercícios físico e diagnóstico automático de patologias usando imagens de alta resolução da retina humana: Contributions to physical therapy protocols efficiency measures and physical exercise and pathologies automatic diagnosis using high definition images of the human retina. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330555

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

15. Kumar Singh, Amar. The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases.

Degree: 2013, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/4380

► Este trabajo se propone la utilización del potencial de diferenciación hacia células con fenotipo EPR que poseen las hAD‐MSCs, simultáneamente con sus beneficiosos efectos paracrinos… (more)

Subjects/Keywords: Retina-enfermedades; Oftalmología

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APA (6^th Edition):

Kumar Singh, A. (2013). The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/4380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kumar Singh, Amar. “The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases.” 2013. Thesis, Universidad de Valladolid. Accessed March 07, 2021. http://uvadoc.uva.es/handle/10324/4380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kumar Singh, Amar. “The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases.” 2013. Web. 07 Mar 2021.

Vancouver:

Kumar Singh A. The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases. [Internet] [Thesis]. Universidad de Valladolid; 2013. [cited 2021 Mar 07]. Available from: http://uvadoc.uva.es/handle/10324/4380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kumar Singh A. The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases. [Thesis]. Universidad de Valladolid; 2013. Available from: http://uvadoc.uva.es/handle/10324/4380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

16. Muñoz Cuéllar, Juan Manuel. Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá.

Degree: 2017, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/25770

► Introducción: Las distrofias retinianas son determinadas genéticamente e implican una gran variabilidad fenotípica y genotípica. En Iberoamérica hay poca literatura sobre sus aspectos fenotípicos, genotípicos… (more)

Subjects/Keywords: Retina-Enfermedades-Panamá

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APA (6^th Edition):

Muñoz Cuéllar, J. M. (2017). Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/25770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Muñoz Cuéllar, Juan Manuel. “Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá.” 2017. Thesis, Universidad de Valladolid. Accessed March 07, 2021. http://uvadoc.uva.es/handle/10324/25770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Muñoz Cuéllar, Juan Manuel. “Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá.” 2017. Web. 07 Mar 2021.

Vancouver:

Muñoz Cuéllar JM. Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá. [Internet] [Thesis]. Universidad de Valladolid; 2017. [cited 2021 Mar 07]. Available from: http://uvadoc.uva.es/handle/10324/25770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Muñoz Cuéllar JM. Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá. [Thesis]. Universidad de Valladolid; 2017. Available from: http://uvadoc.uva.es/handle/10324/25770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Harvard University

17. Liu, Jinyue. Molecular Determinants of Dendritic Patterning in the Mammalian Retina.

Degree: PhD, 2017, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224

►

The architecture of dendritic arbors is a critical element in neuronal connectivity and function, influencing partner choice, synaptic wiring and computational properties. Unraveling core principles… (more)

▼

The architecture of dendritic arbors is a critical element in neuronal connectivity and function, influencing partner choice, synaptic wiring and computational properties. Unraveling core principles in dendritic patterning is thus an outstanding objective in neurodevelopment research. Here, I report my efforts towards this goal, utilizing the morphological diversity of retinal ganglion cells (RGCs) in mammalian retina to elucidate the cellular and molecular logic behind dendritic patterning. To begin, I characterized how RGCs belonging to one type, called J-RGC, coordinate dendritic patterning across time and space to produce a stereotyped morphology. I showed that ventral asymmetry of J-RGC dendrites develops in a protracted dorsoventral wave while their lamination within the inner plexiform layer (IPL) develops rapidly in a centrifugal wave. Each ventrally-asymmetric, lamina-restricted arbor bears an asymmetric distribution of inhibitory synapses, the formation of which, surprisingly, lags behind that of excitatory synapses. Thus, distinct mechanisms operate in different dimensions of J-RGC dendritic patterning to generate the appropriate substrate for highly specific modes of synaptogenesis. Next, I present work on the intrinsic control of dendritic patterning in RGCs like J-RGCs. Using transcriptomic profiling with molecular, transgenic and spatial mosaic analyses, I discovered that the transcription factor T-box Brain 1 (Tbr1) is selectively expressed by J-RGCs and three other RGC types. All of them send dendrites to the outer half of the IPL. Using loss- and gain-of-function approaches, I demonstrated that Tbr1 is both necessary and instructive for laminar specification of RGC dendrites. Therefore, Tbr1 is a transcriptional determinant of laminar identity for RGC dendrites. Finally, I describe the roles of cell-surface molecules in Tbr1-driven, type-specific dendritic patterning. I showed that a classical cadherin, Cdh8, and a growth factor receptor, Sorcs3, are localized to J-RGC dendrites, regulated by Tbr1 and capable of affecting lamination by themselves. Thus Tbr1 acts in part via Cdh8 and Sorcs3 to specify the laminar identity of J-RGC dendrites. My work puts forth the concept that a single transcriptional determinant can drive a common dendritic lamination pattern presented by different RGC types. Each determinant can then employ multiple and type-specific mediators to establish key aspects of that lamination program.

Medical Sciences

Advisors/Committee Members: Sanes, Joshua (advisor), Goodrich, Lisa (committee member), Arlotta, Paola (committee member), Mason, Carol (committee member).

Subjects/Keywords: Retina; Dendritic patterning

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APA (6^th Edition):

Liu, J. (2017). Molecular Determinants of Dendritic Patterning in the Mammalian Retina. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224

Chicago Manual of Style (16^th Edition):

Liu, Jinyue. “Molecular Determinants of Dendritic Patterning in the Mammalian Retina.” 2017. Doctoral Dissertation, Harvard University. Accessed March 07, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224.

MLA Handbook (7^th Edition):

Liu, Jinyue. “Molecular Determinants of Dendritic Patterning in the Mammalian Retina.” 2017. Web. 07 Mar 2021.

Vancouver:

Liu J. Molecular Determinants of Dendritic Patterning in the Mammalian Retina. [Internet] [Doctoral dissertation]. Harvard University; 2017. [cited 2021 Mar 07]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224.

Council of Science Editors:

Liu J. Molecular Determinants of Dendritic Patterning in the Mammalian Retina. [Doctoral Dissertation]. Harvard University; 2017. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224

Boston University

18. Slick, Nathalie Rose. Ocular manifestations of chronic traumatic encephalopathy.

Degree: MS, Medical Sciences, 2014, Boston University

URL: http://hdl.handle.net/2144/14360

► Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that is characterized by a tauopathy in the form of aggregates of hyperphosphorylated tau throughout the… (more)

Subjects/Keywords: Neurosciences; CTE; Retina

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APA (6^th Edition):

Slick, N. R. (2014). Ocular manifestations of chronic traumatic encephalopathy. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14360

Chicago Manual of Style (16^th Edition):

Slick, Nathalie Rose. “Ocular manifestations of chronic traumatic encephalopathy.” 2014. Masters Thesis, Boston University. Accessed March 07, 2021. http://hdl.handle.net/2144/14360.

MLA Handbook (7^th Edition):

Slick, Nathalie Rose. “Ocular manifestations of chronic traumatic encephalopathy.” 2014. Web. 07 Mar 2021.

Vancouver:

Slick NR. Ocular manifestations of chronic traumatic encephalopathy. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2144/14360.

Council of Science Editors:

Slick NR. Ocular manifestations of chronic traumatic encephalopathy. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14360

University of Illinois – Urbana-Champaign

19. Jones, Alicia R. Retinal mophology and intelligence.

Degree: MS, Kinesiology, 2018, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/101035

► Objective: To investigate the relationship between retinal morphometric measures and intellectual abilities among adults with overweight and obesity. Methods: Adults between 25-45 years (N=55, 38… (more)

Subjects/Keywords: Retina; IQ; OCT

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APA (6^th Edition):

Jones, A. R. (2018). Retinal mophology and intelligence. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/101035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, Alicia R. “Retinal mophology and intelligence.” 2018. Thesis, University of Illinois – Urbana-Champaign. Accessed March 07, 2021. http://hdl.handle.net/2142/101035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, Alicia R. “Retinal mophology and intelligence.” 2018. Web. 07 Mar 2021.

Vancouver:

Jones AR. Retinal mophology and intelligence. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2142/101035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones AR. Retinal mophology and intelligence. [Thesis]. University of Illinois – Urbana-Champaign; 2018. Available from: http://hdl.handle.net/2142/101035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Altavilla, Cesare. Efectos del cannabinoide HU210 y la nicotina en un modelo de degeneración de la retina .

Degree: 2015, University of Alicante

URL: http://hdl.handle.net/10045/51229

► La retina es un tejido sensible a la luz que recubre la superficie interna del ojo. La complejidad estructural y funcional de la retina hacen… (more)

▼ La retina es un tejido sensible a la luz que recubre la superficie interna del ojo. La complejidad estructural y funcional de la retina hacen de este tejido uno de los más vulnerables a alteraciones provocadas por todo tipo de lesión o enfermedad. Las enfermedades del sistema visual conllevan para los sujetos afectados una mengua en la calidad de vida. Entre las enfermedades degenerativas de tipo genético del sistema visual, la retinosis pigmentaria (RP) es una de las más importantes por incidencia y porque al día de hoy no existe terapia curativa efectiva. La RP comprende un conjunto de enfermedades neurodegenerativas de la retina que afectan principalmente a los fotorreceptores, produciendo una pérdida gradual de la visión y desembocando paulatinamente en ceguera. Sin embargo, son varias las alternativas terapéuticas que se están investigando en la actualidad con el fin curar la enfermedad. La terapia génica, las células encapsuladas, la optogenética, el trasplante de células madre y, por último, los chips electrónicos, son estrategias con un futuro esperanzador en la curación de la enfermedad. Mientras tanto, con el objetivo de retardar la evolución de la enfermedad y la degeneración del sistema visual, se ha planteado estudiar otros posibles tratamientos que puedan retrasar la evolución de la RP y mejorar la calidad de vida de los sujetos afectados. La investigación en los últimos 20 años, gracias a las nuevas tecnologías disponibles, ha demostrado que las sustancias antiapoptóticas, antioxidantes, factores tróficos y neuroprotectores influencian la degeneración retiniana. El presente trabajo persigue estudiar 2 sustancias, una de origen natural y otra sintética, con el objetivo de encontrar agentes capaces de enlentecer el decurso degenerativo de la retina en el modelo murino de retinosis pigmentaria P23H, siempre teniendo en cuenta la inquietud de encontrar un tratamiento terapéutico aplicable a seres humanos en el futuro. El objetivo de este trabajo es determinar el posible potencial terapéutico, en tratamiento crónico, de las sustancias elegidas. El Cannabinoide sintético HU210 podría retrasar o prevenir la degeneración y la muerte de los fotorreceptores y del entramado sináptico de la retina. En anteriores estudios publicados, HU210 protege las células neuronales en varias enfermedades neurodegenerativas como la enfermedad de Alzheimer, la enfermedad de Parkinson y el estrés isquémico. Además, se han descrito efectos sobre la reducción de la presión intraocular en relación con el glaucoma. La nicotina podría retrasar o prevenir la degeneración y la muerte de los fotorreceptores y otras neuronas de la retina, actuando sobre los receptores nicotínicos. En este caso la bibliografía es un poco más escasa y ambigua, pero quisimos comprobar si la suministración crónica de nicotina podría tener algún efecto positivo sobre el transcurso de la enfermedad retiniana. La eficacia de los tratamientos fue evaluada mediante registros electrorretinográficos, con objeto de medir la actividad funcional de la retina. También… Advisors/Committee Members: Lax Zapata, Pedro (advisor), Cuenca Navarro, Nicolás (advisor).

Subjects/Keywords: Retina; Neuroprotección; Fotorreceptores

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APA (6^th Edition):

Altavilla, C. (2015). Efectos del cannabinoide HU210 y la nicotina en un modelo de degeneración de la retina . (Thesis). University of Alicante. Retrieved from http://hdl.handle.net/10045/51229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Altavilla, Cesare. “Efectos del cannabinoide HU210 y la nicotina en un modelo de degeneración de la retina .” 2015. Thesis, University of Alicante. Accessed March 07, 2021. http://hdl.handle.net/10045/51229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Altavilla, Cesare. “Efectos del cannabinoide HU210 y la nicotina en un modelo de degeneración de la retina .” 2015. Web. 07 Mar 2021.

Vancouver:

Altavilla C. Efectos del cannabinoide HU210 y la nicotina en un modelo de degeneración de la retina . [Internet] [Thesis]. University of Alicante; 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10045/51229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Altavilla C. Efectos del cannabinoide HU210 y la nicotina en un modelo de degeneración de la retina . [Thesis]. University of Alicante; 2015. Available from: http://hdl.handle.net/10045/51229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

21. WAUGH, MICHELLE. The role of chemokines in the retina.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/38187

► This thesis investigates mice with genetic knock-outs in certain chemokines or their receptors which have shown signs of Age Related Macula Degeneration (AMD) by causing… (more)

Subjects/Keywords: chemokines; inflammation; retina

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APA (6^th Edition):

WAUGH, M. (2013). The role of chemokines in the retina. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38187

Chicago Manual of Style (16^th Edition):

WAUGH, MICHELLE. “The role of chemokines in the retina.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 07, 2021. http://hdl.handle.net/11343/38187.

MLA Handbook (7^th Edition):

WAUGH, MICHELLE. “The role of chemokines in the retina.” 2013. Web. 07 Mar 2021.

Vancouver:

WAUGH M. The role of chemokines in the retina. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/11343/38187.

Council of Science Editors:

WAUGH M. The role of chemokines in the retina. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38187

University of Melbourne

22. van Koeverden, Anna Kiara. The effect of chronic hypertension on retinal susceptibility to chronic intraocular pressure elevation.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/115280

► Higher blood pressure and thus better blood flow should protect the eye against glaucoma, but epidemiological studies suggest the opposite. This thesis provides direct experimental… (more)

Subjects/Keywords: retina; glaucoma; hypertension

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APA (6^th Edition):

van Koeverden, A. K. (2016). The effect of chronic hypertension on retinal susceptibility to chronic intraocular pressure elevation. (Masters Thesis). University of Melbourne. Retrieved from http://hdl.handle.net/11343/115280

Chicago Manual of Style (16^th Edition):

van Koeverden, Anna Kiara. “The effect of chronic hypertension on retinal susceptibility to chronic intraocular pressure elevation.” 2016. Masters Thesis, University of Melbourne. Accessed March 07, 2021. http://hdl.handle.net/11343/115280.

MLA Handbook (7^th Edition):

van Koeverden, Anna Kiara. “The effect of chronic hypertension on retinal susceptibility to chronic intraocular pressure elevation.” 2016. Web. 07 Mar 2021.

Vancouver:

van Koeverden AK. The effect of chronic hypertension on retinal susceptibility to chronic intraocular pressure elevation. [Internet] [Masters thesis]. University of Melbourne; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/11343/115280.

Council of Science Editors:

van Koeverden AK. The effect of chronic hypertension on retinal susceptibility to chronic intraocular pressure elevation. [Masters Thesis]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/115280

University of Melbourne

23. Wang, Jiang Hui. Role of microRNAs in retinal neovascularization.

Degree: 2018, University of Melbourne

URL: http://hdl.handle.net/11343/213898

► MicroRNAs (miRNAs) are master gene regulators that have been widely implicated in many biological processes as well as pathogenesis of many diseases in the eye.… (more)

▼ MicroRNAs (miRNAs) are master gene regulators that have been widely implicated in many biological processes as well as pathogenesis of many diseases in the eye. The identification of miRNAs that are altered in human diseases as well as in animal models has led to new avenues to develop novel therapeutic targets for ocular disorders. The broad focus of studies described in this thesis is the identification of miRNAs that have altered expression during neovascularization of the retina using a rat model of oxygen-induced retinopathy (OIR). miRNA-Seq studies carried out in rats, mice and humans show that retinal miRNAs in rats and mice are highly homologous with humans. In exploring the altered miRNAs in retinal neovascularization, we found four miRNAs of interest (miR-143, miR-126, miR-150 and miR-145) that were down-regulated in the retina preceding neovascularization in OIR rats. Further investigation suggested that transforming growth factor-beta activated kinase 1 (TAK1), a target gene of miRNA-143, was highly up-regulated in the retina of OIR rats. Selectively pharmacological inhibition of TAK1 activity by 5Z-7-Oxozeaenol led to significant reduction of angiogenic capability of human endothelial cells, as measured by cell proliferation, cell migration and tube formation. Moreover, 5Z-7-Oxozeaenol greatly suppressed vascular spouting of mice aortic explants. In vivo intravitreal administration of 5Z-7-Oxozeaenol profoundly attenuated the retinal neovascularization in OIR rats. Previous studies have reported the down-regulation of miR-126 and miR-150 in OIR mice, and the restoration of these altered miRNAs led to significant suppression of retinal neovascularization in vivo. Here we focus on miR-143 rather than miR-126 and miR-150 to explore its therapeutic potential and underlying mechanisms in retinal neovascularization. Intravitreal administration of a synthetic miR-143 mimic into the eyes of OIR rats suppressed retinal neovascularization by ~50%. Further RNA-Seq identified that a gene cluster mediated by Fos, an inflammatory and stress gene, plays a crucial role in the suppression of retinal neovascularization in OIR rats by the restoration of miR-143. Plasmid vectors of reporter genes and corresponding elements of altered miRNAs such as miR-143, miR-126 and miR-150 were devised. Co-transfecting the devised plasmids with corresponding mimic of the altered miRNAs in HEK293A cells inhibited reporter gene expression. In the context of gene therapy for retinal neovascularization, the results indicate that therapeutic gene expression could be regulated in accordance with the disease activity through altered miRNAs.

Subjects/Keywords: microRNA; neovascularization; retina

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APA (6^th Edition):

Wang, J. H. (2018). Role of microRNAs in retinal neovascularization. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/213898

Chicago Manual of Style (16^th Edition):

Wang, Jiang Hui. “Role of microRNAs in retinal neovascularization.” 2018. Doctoral Dissertation, University of Melbourne. Accessed March 07, 2021. http://hdl.handle.net/11343/213898.

MLA Handbook (7^th Edition):

Wang, Jiang Hui. “Role of microRNAs in retinal neovascularization.” 2018. Web. 07 Mar 2021.

Vancouver:

Wang JH. Role of microRNAs in retinal neovascularization. [Internet] [Doctoral dissertation]. University of Melbourne; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/11343/213898.

Council of Science Editors:

Wang JH. Role of microRNAs in retinal neovascularization. [Doctoral Dissertation]. University of Melbourne; 2018. Available from: http://hdl.handle.net/11343/213898

University of Melbourne

24. Waugh, Hayley Shian. Amyloid precursor protein-mediated neuroprotection and processing in the aged retina.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/38425

► The world’s population is ageing and this means an increase in diseases in which age is a risk factor including Alzheimer’s disease (AD), Parkinson’s disease… (more)

▼ The world’s population is ageing and this means an increase in diseases in which age is a risk factor including Alzheimer’s disease (AD), Parkinson’s disease (PD), age-related macular degeneration (AMD) and glaucoma. Classic pathological hallmarks of AD include intracellular neurofibrillary tangles (NFTs), rich in phosphorylated tau protein, and extracellular amyloid plaques containing amyloid beta (Aβ). This is accompanied by neuronal loss and decline in cognitive function. Neuronal loss is also a feature of glaucoma with the selective death of retinal ganglion cells (RGCs) and there is RGC loss observed in AD patients. There is also evidence of increased incidence of glaucoma in AD patients compared to control populations. Aβ is produced as part of amyloidogenic cleavage of the amyloid precursor protein (APP); a large membrane bound protein with a putative receptor-type function. An alternative cleavage pathway, termed non-amyloidogenic, prevents Aβ formation and instead produces the neuroprotective and neurotrophic molecule soluble APPα (sAPPα). The majority of APP cleavage is via the non-amyloidogenic pathway but conditions such as oxidative stress drive increased cleavage through the amyloidogenic pathway. This reduces the pool of protective sAPPα available and may render neurons, including ageing neurons more susceptible to injury. Soluble APPα has demonstrated protection against a wide range of insults including the mitochondrial complex I inhibitor rotenone and this protection is linked to activation of the PI3K/Akt pathway. The work described in this thesis aimed to further elucidate mechanisms of APP-driven neuroprotection against mitochondrial insult, and whether this may represent a drug target in the retina. To examine the mechanism by which sAPPα acts we used rotenone toxicity in human neuronal cells. Cells overexpressing wild-type APP695 (APPwt) displayed increased survival after exposure to rotenone and a second complex I inhibitor MPP+. APPwt overexpression lead to activation of Akt in rotenone treated cells. Akt is a serine/threonine kinase central to survival and apoptosis pathways. We found that APPwt overexpressing cells also showed inactivation of pro-apoptotic Gsk3β downstream of Akt while a second downstream target Bad was not affected by APP. Control cells did show Bad inactivation suggesting that sAPPα-mediated protection overcomes the need for this aspect of the PI3K pathway to be utilised. Intravitreal delivery of rotenone in rodents induces an optic neuropathy specifically targeting the inner retina. We found that sAPPα treatment post-rotenone injury reduced apoptosis in both the ganglion cell and inner nuclear layers. Soluble APPα treatment also reduced levels of the stress response indicator protein, heme oxygenase-1 (HO-1), in a second retinal stress model of mild intraocular pressure elevation. Together these studies suggest that sAPPα has therapeutic value worthy of further exploration. …

Subjects/Keywords: APP; ageing; retina

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APA (6^th Edition):

Waugh, H. S. (2013). Amyloid precursor protein-mediated neuroprotection and processing in the aged retina. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38425

Chicago Manual of Style (16^th Edition):

Waugh, Hayley Shian. “Amyloid precursor protein-mediated neuroprotection and processing in the aged retina.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 07, 2021. http://hdl.handle.net/11343/38425.

MLA Handbook (7^th Edition):

Waugh, Hayley Shian. “Amyloid precursor protein-mediated neuroprotection and processing in the aged retina.” 2013. Web. 07 Mar 2021.

Vancouver:

Waugh HS. Amyloid precursor protein-mediated neuroprotection and processing in the aged retina. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/11343/38425.

Council of Science Editors:

Waugh HS. Amyloid precursor protein-mediated neuroprotection and processing in the aged retina. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38425

University of New South Wales

25. Yin, Shijie. Computational model of the retinal network.

Degree: Graduate School of Biomedical Engineering, 2012, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true

► The loss of vision through degenerative retinal diseases is a tragic human condition affecting millions around the world. Development of a visual prosthetic device hoping… (more)

▼ The loss of vision through degenerative retinal diseases is a tragic human condition affecting millions around the world. Development of a visual prosthetic device hoping to restore vision to these patients is underway by electrically stimulating the retinal ganglion cells of the retina with nearby electrodes. These neurons responsible for the transmission of electrical signals to the visual cortex of the brain are thought to be largely intact even in patients who have been blind for many years. The pursuit of eliciting useful vision faces a great number of challenges in both device design and stimulation strategy. Powerful tools such as mathematical models can assist by redirecting the focus of implant and stimulus algorithm design to critical areas.Previous retinal models primarily focused on either a compartmental approach employing active descriptions of cellular membrane mechanisms or discrete network models. However, the extent of spatial activation of the retina on a large scale is not considered, nor are the effects of the network in shaping spiking activity taken into account in a continuum sense. The development of a novel pseudo-bidomain model incorporating presynaptic inputs from deeper retinal neurons will be presented in this thesis. Model parameters are tuned to reflect feasible responses to epiretinal stimulation and validated against suprachoroidal stimulation and various electrode and stimulus configurations.Simulation findings suggest a threshold charge density for activation of 50 ± 2 µC/cm2 for epiretinal stimulation with a disc electrode of 200 µm radius and a rectangular cathodic stimulus of 100 µs pulse width. For suprachoroidal stimulation, this was observed to be 137 ± 2 µC/cm2. Inclusion of presynaptic inputs elicited stimulus-locked and network driven action potentials. For epiretinal stimulation presence of early and late onset action potentials were observed with latencies of 0.3 and 7 ms respectively with a charge density of 398 - 438 µC/cm2. In comparison suprachoroidal stimulation displayed an earlier network driven response (6.4 ms) at a lower charge density of 223 - 231 µC/cm2. These near threshold and latency findings were consistent with published works and present a novel approach to examining retinal activation in a spatiotemporal setting.

Subjects/Keywords: Stimulation; Retina; Model

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APA (6^th Edition):

Yin, S. (2012). Computational model of the retinal network. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Yin, Shijie. “Computational model of the retinal network.” 2012. Doctoral Dissertation, University of New South Wales. Accessed March 07, 2021. http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Yin, Shijie. “Computational model of the retinal network.” 2012. Web. 07 Mar 2021.

Vancouver:

Yin S. Computational model of the retinal network. [Internet] [Doctoral dissertation]. University of New South Wales; 2012. [cited 2021 Mar 07]. Available from: http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true.

Council of Science Editors:

Yin S. Computational model of the retinal network. [Doctoral Dissertation]. University of New South Wales; 2012. Available from: http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true

Rutgers University

26. Rayaji, Rameshwari, 1990-. Effect of Top2b inhibition on cadherin expression in developing chicken retina.

Degree: MS, Biomedical Engineering, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51439/

► Retinal development involves defined guidance of neuronal axons to their destined cells through cell adhesion molecules, by compilation of cell-cell connections at synapses. Cell adhesion… (more)

▼ Retinal development involves defined guidance of neuronal axons to their destined cells through cell adhesion molecules, by compilation of cell-cell connections at synapses. Cell adhesion molecules promote oriented axonal outgrowth and help in target synaptic specificity to maintain histoarchitecture of retina. Cell adhesion molecules like cadherins are the products of expression of long genes >200 kilobases of genomic DNA. Topoisomerase II beta (Top2b) involved in modulating DNA supercoiling by catalyzing the double strand breaks and passing the stands through one another. Top2b is pervasively expressed in all terminally differentiated cells and participates in gene transcription. Recent studies have shown that Top2b facilitates the expression of long genes. However, its particular role in transcription of cadherins and effect on organization of retinal cells such as retinal ganglion cells and horizontal cells remain unclear. In current study, the role of Top2b in expression of cadherin genes was analyzed in iii developing chick retina via immunohistochemistry and real-time PCR. Top2b function in developing retina was inhibited by injections of 500µM Top2b catalytic inhibitor (ICRF-193) into sub-retinal space at embryonic day 4 (E4). Retinal tissues were analyzed by immunohistochemistry using cell specific markers, e.g., Brn3a for ganglion cells, 4F2 for horizontal cells, and Tuj1 for neuronal processes at E6, E8, E10, and E12. We showed that inhibition of Top2b by ICRF-193 i) reduced the expression level of cadherin genes, e.g., N-cadherin (Cdh2), Cadherin-6B (Cad6B), Cadherin-7 (Cdh7), and Cadhrin-8 (Cdh8)in developing retina; ii)led to a disoriented cellular organization; and iii) delayed migration of RGCs and HCs. The results from immunohistochemistry were confirmed by quantitative real-time PCR (qRT-PCR). Results from qRT-PCR showed significant reduction in expression levels of cadherin genes, e.g., Cad6B and Cdh7 with an average fold reduction of 2.5 prominent at embryonic day 10 (E10) (p <0.02, p<0.006), respectively and Cdh8 with an average fold reduction of 4 prominent at embryonic day 8 (E8) (p <0.02), however expression of Cdh2 was not effected by Top2b inhibition at E6-E12. This study helps to understand the molecular basis of vertebrate retinal development via calcium-dependent intercellular cell adhesion molecules and revealed the vital role of Top2b in expression of cadherin genes. Advisors/Committee Members: Cai, Li (chair).

Subjects/Keywords: Cadherins; Retina – Growth

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APA (6^th Edition):

Rayaji, Rameshwari, 1. (2016). Effect of Top2b inhibition on cadherin expression in developing chicken retina. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51439/

Chicago Manual of Style (16^th Edition):

Rayaji, Rameshwari, 1990-. “Effect of Top2b inhibition on cadherin expression in developing chicken retina.” 2016. Masters Thesis, Rutgers University. Accessed March 07, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/51439/.

MLA Handbook (7^th Edition):

Rayaji, Rameshwari, 1990-. “Effect of Top2b inhibition on cadherin expression in developing chicken retina.” 2016. Web. 07 Mar 2021.

Vancouver:

Rayaji, Rameshwari 1. Effect of Top2b inhibition on cadherin expression in developing chicken retina. [Internet] [Masters thesis]. Rutgers University; 2016. [cited 2021 Mar 07]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51439/.

Council of Science Editors:

Rayaji, Rameshwari 1. Effect of Top2b inhibition on cadherin expression in developing chicken retina. [Masters Thesis]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51439/

Rutgers University

27. Demmin, Docia L., 1991-. The relationship between retinal and cognitive functioning in schizophrenia.

Degree: MS, Psychology, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/61728/

► The retina may provide a unique window into brain structure and function as an accessible part of the central nervous system. Abnormalities in retinal cell… (more)

▼ The retina may provide a unique window into brain structure and function as an accessible part of the central nervous system. Abnormalities in retinal cell structure and function have been associated with brain pathology (e.g., brain volume loss, cognitive impairment, functional disability) in several neuropsychiatric disorders (e.g., Multiple Sclerosis, Alzheimer’s disease, Parkinson’s disease). A number of prior studies using flash electroretinography (fERG) have observed a reduction in retinal cell activity in schizophrenia (SZ). Impairments in cognitive functioning are a core feature of SZ and deficits in executive control processes involving prefrontal cortex (PFC) activity (i.e., working memory, attention, executive functioning), are strong indicators of functional capacity. However, it is not known how anomalies in retinal cell signaling may relate to cognitive changes in SZ. This study examined whether retinal cell functioning is related to brain function, as indexed by cognitive function, in SZ, and if these relationships were stronger in particular domains (e.g., PFC dependent functions vs. less PFC dependent functions). Twenty-six SZ participants and 24 healthy controls (HC) completed an fERG protocol and cognitive test battery. fERG measurements included a-wave (photoreceptor cells), b-wave (bipolar-Müller cell cells), and oscillatory potential (OP; amacrine cells) amplitudes and implicit times. Cognitive tests assessed executive control processes such as attention/speed of information processing, behavior initiation, response inhibition, and working memory, and non-executive control processes such as emotion recognition and discrimination. fERG and cognitive test data were examined for between-group differences. The relationship between fERG variables and cognitive test scores within each group was assessed with Pearson correlations and hierarchical multiple regression analyses. Canonical correlations were also performed to determine if a set of fERG variables was significantly related to a set of cognitive functioning variables. Our results confirm those of prior studies demonstrating anomalies in a-wave and b-wave activity and lower cognitive test performance in SZ, in comparison to controls. In the HC group, a-wave amplitude was correlated with cognitive test scores and OP amplitude was related to cognitive test performance in the SZ group. However, overall, retinal cell activity did not appear to be strongly related to scores on cognitive tasks, regardless of whether or not they involved frontal brain regions. Thus, impairments in retinal and cognitive functioning may reflect distinct disease mechanisms in schizophrenia. Additional studies of larger sample sizes are needed in order to determine the similarity between retinal cell functioning and cognitive functioning in SZ. Advisors/Committee Members: Silverstein, Steven M (chair), Shors, Tracey (internal member), Kusnecov, Alexander (internal member), School of Graduate Studies.

Subjects/Keywords: Schizophrenia – Diagnosis; Retina

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APA (6^th Edition):

Demmin, Docia L., 1. (2019). The relationship between retinal and cognitive functioning in schizophrenia. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/61728/

Chicago Manual of Style (16^th Edition):

Demmin, Docia L., 1991-. “The relationship between retinal and cognitive functioning in schizophrenia.” 2019. Masters Thesis, Rutgers University. Accessed March 07, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/61728/.

MLA Handbook (7^th Edition):

Demmin, Docia L., 1991-. “The relationship between retinal and cognitive functioning in schizophrenia.” 2019. Web. 07 Mar 2021.

Vancouver:

Demmin, Docia L. 1. The relationship between retinal and cognitive functioning in schizophrenia. [Internet] [Masters thesis]. Rutgers University; 2019. [cited 2021 Mar 07]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61728/.

Council of Science Editors:

Demmin, Docia L. 1. The relationship between retinal and cognitive functioning in schizophrenia. [Masters Thesis]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61728/

Universidade do Rio Grande do Sul

28. Ferreira, Thiago Vernetti. Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil.

Degree: 2012, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/61904

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O estudo Elsa-Brasil visa à investigação de fatores de risco para saúde da população adulta, sendo realizado em seis estados brasileiros. Os participantes foram submetidos,… (more)

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O estudo Elsa-Brasil visa à investigação de fatores de risco para saúde da população adulta, sendo realizado em seis estados brasileiros. Os participantes foram submetidos, na linha de base, a diferentes exames, entre os quais a retinografia. A análise da retinografia foi realizada para identificar anormalidades de fundo de olho como retinopatia diabética, degeneração macular relacionada à idade, entre outros. Participantes com tais anomalias foram notificados em conformidade. O centro de leitura de retinografia tinha seis leitores certificados disponíveis para analisar as fotografias do fundo de olho. Os leitores foram treinados de acordo com a sua formação profissional prévia. Entre os oftalmologistas a padronização enfatizou a classificação de resultados anormais e estabelecimento dos resultados. Para estudantes de medicina, um mínimo de três meses de treinamento com um oftalmologista foi necessário antes de iniciar as leituras. O supervisor realizou controle periódico de qualidade das imagens no Centro de leitura de retinografia. No total, foram avaliadas mais de 40.000 imagens de fundo (cerca de quatro por participante). Análise de confiabilidade intra e interobservador foram realizadas para legibilidade das imagens e presença de achados anormais. Avaliaram-se as fotografias de fundo de olho de 10.648 participantes do estudo ELSA, com 52,8 ±9.2 anos, 53,5% eram mulheres e mais de 60% tinha iniciado ou concluído uma licenciatura. Os centros com maior número de participantes foram São Paulo, Minas Gerais, Rio Grande do Sul, Rio de Janeiro, Bahia e Espírito Santo, respectivamente. Cerca de 91% das imagens, tanto para olho direito como olho esquerdo, foram legíveis, 12% dos participantes apresentaram achados compatíveis com alteração ocular, demandando confirmação diagnóstica por especialista. A concordância interobservador para legibilidade e resultado da leitura (normal, alterado ou inconclusivo) obteve um coeficiente kappa moderado para ambos os olhos (entre 0,4 e 0,6). Em relação à análise intraobservador, o kappa obtido para resultado da leitura foi bom (entre 0,6 e 0,8) e para legibilidade foi moderado. Diferenças de formação e experiência entre leitores poderiam explicar tanto a variação nos coeficientes kappa para o intraobservador, quanto o kappa global. O coeficiente kappa para análise intraobservador de resultado foi bom, sendo que entre os leitores experientes houve maior concordância. Por outro lado, maior número de leitores, incluindo os com maior e menor experiência, permitiu obter coeficiente kappa moderado para análise interobservador de avaliação de anormalidades. Finalmente, os resultados mostraram adequada concordância entre observadores e os achados da retina podem ser usados para avaliar associações com desfechos clínicos incidentes nesta coorte. Os resultados indicam que a avaliação de confiabilidade intraobservador é necessária e que os leitores devem ser experientes ou treinados de forma mais consistente e por mais tempo.

The ELSA-Brasil study aims to investigate risk factors for health…

Advisors/Committee Members: Fuchs, Sandra Cristina Pereira Costa.

Subjects/Keywords: Reprodutibilidade dos testes; Retina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferreira, T. V. (2012). Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/61904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferreira, Thiago Vernetti. “Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil.” 2012. Thesis, Universidade do Rio Grande do Sul. Accessed March 07, 2021. http://hdl.handle.net/10183/61904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferreira, Thiago Vernetti. “Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil.” 2012. Web. 07 Mar 2021.

Vancouver:

Ferreira TV. Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2012. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10183/61904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferreira TV. Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil. [Thesis]. Universidade do Rio Grande do Sul; 2012. Available from: http://hdl.handle.net/10183/61904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

29. Firl, Alana. Mechanisms underlying spontaneous glutamatergic activity in developing mouse retina.

Degree: Vision Science, 2014, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/3nx6s267

► Throughout the developing nervous system, spontaneous oscillatory patterns of activity have been observed. The developing murine retina is no exception, where spontaneous activity manifests as… (more)

Subjects/Keywords: Neurosciences; development; glutamate; retina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Firl, A. (2014). Mechanisms underlying spontaneous glutamatergic activity in developing mouse retina. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/3nx6s267

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Firl, Alana. “Mechanisms underlying spontaneous glutamatergic activity in developing mouse retina.” 2014. Thesis, University of California – Berkeley. Accessed March 07, 2021. http://www.escholarship.org/uc/item/3nx6s267.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Firl, Alana. “Mechanisms underlying spontaneous glutamatergic activity in developing mouse retina.” 2014. Web. 07 Mar 2021.

Vancouver:

Firl A. Mechanisms underlying spontaneous glutamatergic activity in developing mouse retina. [Internet] [Thesis]. University of California – Berkeley; 2014. [cited 2021 Mar 07]. Available from: http://www.escholarship.org/uc/item/3nx6s267.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Firl A. Mechanisms underlying spontaneous glutamatergic activity in developing mouse retina. [Thesis]. University of California – Berkeley; 2014. Available from: http://www.escholarship.org/uc/item/3nx6s267

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Quesada Ruiz, Adela. Evolución histogenética de las células bipolares de la retina un estudio en el embrión de pollo.

Degree: 1982, Universidad de Sevilla

URL: http://hdl.handle.net/11441/23835

► La estructura retiniana representa, aún hoy día, uno de los problemas del sistema nervioso que sigue ofreciendo lagunas y planteando incógnitas. Ramón y Cajal en… (more)

Subjects/Keywords: Retina; Ojo

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Quesada Ruiz, A. (1982). Evolución histogenética de las células bipolares de la retina un estudio en el embrión de pollo. (Thesis). Universidad de Sevilla. Retrieved from http://hdl.handle.net/11441/23835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Quesada Ruiz, Adela. “Evolución histogenética de las células bipolares de la retina un estudio en el embrión de pollo.” 1982. Thesis, Universidad de Sevilla. Accessed March 07, 2021. http://hdl.handle.net/11441/23835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Quesada Ruiz, Adela. “Evolución histogenética de las células bipolares de la retina un estudio en el embrión de pollo.” 1982. Web. 07 Mar 2021.

Vancouver:

Quesada Ruiz A. Evolución histogenética de las células bipolares de la retina un estudio en el embrión de pollo. [Internet] [Thesis]. Universidad de Sevilla; 1982. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/11441/23835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Quesada Ruiz A. Evolución histogenética de las células bipolares de la retina un estudio en el embrión de pollo. [Thesis]. Universidad de Sevilla; 1982. Available from: http://hdl.handle.net/11441/23835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations