subject:(Retina)

University of Hawaii

1. Kato, Susumu. Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus.

Degree: 2015, University of Hawaii

URL: http://hdl.handle.net/10125/36006

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Typescript.

Bibliography: leaves 63-67.

v, 67 leaves mounted illustrations (part color) tables

This thesis is concerned with the retinal histology of two species of sharks… (more)

Subjects/Keywords: Sharks; Retina; Retina; Sharks

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APA (6^th Edition):

Kato, S. (2015). Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus. (Thesis). University of Hawaii. Retrieved from http://hdl.handle.net/10125/36006

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kato, Susumu. “Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus.” 2015. Thesis, University of Hawaii. Accessed December 14, 2019. http://hdl.handle.net/10125/36006.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kato, Susumu. “Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus.” 2015. Web. 14 Dec 2019.

Vancouver:

Kato S. Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus. [Internet] [Thesis]. University of Hawaii; 2015. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10125/36006.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kato S. Histology of the retinas of the Pacific sharks Carcharhinus melanopterus and Triaenodon obesus. [Thesis]. University of Hawaii; 2015. Available from: http://hdl.handle.net/10125/36006

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

2. Buttery, Robert Gordon. Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels.

Degree: 1990, University of Tasmania

URL: https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf

► The physical requirements necessary for the perception of light have produced peculiar adaptions to the way in which the eye is nourished. In many mammals… (more)

▼ The physical requirements necessary for the perception of light have produced peculiar adaptions to the way in which the eye is nourished. In many mammals there is a dual blood supply to the retina derived from both choroidal and intraretinal circulations. Interestingly, some species have only a choroidal blood supply. This study has addressed the coping strategies of those retinae which lack intraretinal blood vessels. Placental guinea pigs and diprotodont marsupial brushtail possums and sugar gliders, all of which lack retinal circulation (avascular retinae) have been compared with placental rats and polyprotodont marsupial quolls, Virginia opossums and Tasmanian devils, all of which possess intraretinal blood vessels (vascular retinae). Functional angiographic study has documented vascular patterns and demonstrated the close arteriovenous pairing within the polyprotodont marsupial retina. Avascular retinae are thinner than their vascular counterparts. The difference is not great (170Am versus 220gm): The limitation in thickness is borne by most retinal laminae but more so by those layers furthest from the choroidal supply. Morphological analysis suggests that spatial visual acuity is comparable in vascular and avascular species. Corrosion casting and microscopy of the ocular vasculature has shown that the choroid of the avascular species examined has no obvious morphological specialisations which might offset the lack of retinal vessels. However, the metabolic pathways within the inner layers of avascular retinae are markedly different, with limited oxidative metabolism as indicated by the activity of the mitochondrial enzyme, cytochrome oxidase. However, ATPase activity, as a measure of overall energy consumption, is known to be high within the inner layers of the avascular guinea pig retina (Ueno et al. 1981). This suggests that low cytochrome oxidase activity need not mean limited functional metabolic capacity. As a morphological accompaniment of oxidative activity, ultrastructural analysis would suggest that mitochondrial numbers may be reduced within the inner retinal layers of avascular retinae when compared with similar regions in vascular retinae. Central to these observations is the clinical question of whether the human retina can mimic the coping strategies of avascular retinae following pathological disruption of its intrinsic vasculature.

Subjects/Keywords: Retina; Retina

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APA (6^th Edition):

Buttery, R. G. (1990). Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Buttery, Robert Gordon. “Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels.” 1990. Thesis, University of Tasmania. Accessed December 14, 2019. https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Buttery, Robert Gordon. “Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels.” 1990. Web. 14 Dec 2019.

Vancouver:

Buttery RG. Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels. [Internet] [Thesis]. University of Tasmania; 1990. [cited 2019 Dec 14]. Available from: https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Buttery RG. Vascularity of mammalian retinae : a comparative anatomical study of mammals with and without intraretinal blood vessels. [Thesis]. University of Tasmania; 1990. Available from: https://eprints.utas.edu.au/18967/1/whole_ButteryRobertGordon1990_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

3. Felder, Anthony E. Multi-modal Imaging of Retinal Oxygenation.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21910

► The retina is a light-sensitive tissue located at the back of the eye and plays a key role in vision. To maintain visual function, the… (more)

▼ The retina is a light-sensitive tissue located at the back of the eye and plays a key role in vision. To maintain visual function, the amount of oxygen in the retina (retinal oxygenation) is highly regulated under normal physiological conditions. However, alteration of retinal oxygenation is implicated in common vision-threatening retinal diseases including diabetic retinopathy, glaucoma and macular degeneration. Additionally, retinal oxygenation can be perturbed and characterized by the physiological challenge of diffuse light flicker stimulation (DLFS). Therefore, research that characterizes retinal oxygenation and its response to DLFS in health and disease is essential. To date, available techniques for the direct assessment of retinal oxygenation are invasive and cannot be used in humans. Therefore, markers of retinal oxygenation in humans – retinal vessel diameter (D), retinal vessel oxygen saturation of hemoglobin (SO2) and the inner retinal oxygen extraction fraction (OEF) – are measured non-invasively instead. However, in animals, retinal oxygenation may be directly assessed by measurement of retinal tissue oxygen tension (tPO2). This thesis describes novel techniques to assess retinal oxygenation markers in humans and tPO2 in rats. An optical imaging system for the non-invasive measurement of retinal oxygenation markers in humans was developed and then applied to assess the effects of diabetic retinopathy disease stage and DLFS on markers. Additionally, the system was modified to measure and mathematically model the temporal dynamic responses of retinal oxygenation markers to DLFS. To address limitations in subjects’ fixation during the assessment of these temporal dynamics, a system for real-time image stabilization was developed. Finally, a technique for the three-dimensional assessment of retinal tPO2 in rats was developed, permitting the evaluation and assessment of multifocal retinal oxygenation abnormalities. Advisors/Committee Members: Shahidi, Mahnaz (advisor).

Subjects/Keywords: retina; oxygenation

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APA (6^th Edition):

Felder, A. E. (2017). Multi-modal Imaging of Retinal Oxygenation. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Felder, Anthony E. “Multi-modal Imaging of Retinal Oxygenation.” 2017. Thesis, University of Illinois – Chicago. Accessed December 14, 2019. http://hdl.handle.net/10027/21910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Felder, Anthony E. “Multi-modal Imaging of Retinal Oxygenation.” 2017. Web. 14 Dec 2019.

Vancouver:

Felder AE. Multi-modal Imaging of Retinal Oxygenation. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10027/21910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Felder AE. Multi-modal Imaging of Retinal Oxygenation. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/21910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

4. Ronellenfitch, Kara. Investigating the possibility of Notch signalling in the adult retina.

Degree: Dept. of Biology, 2013, University of Victoria

URL: http://hdl.handle.net/1828/4858

► The Notch signalling pathway is a highly conserved cell-to-cell signalling pathway involved in developmental cell fate determination in all metazons. When Notch is signalling, differentiation… (more)

▼ The Notch signalling pathway is a highly conserved cell-to-cell signalling pathway involved in developmental cell fate determination in all metazons. When Notch is signalling, differentiation is inhibited and a progenitor-like state is favoured. This signalling pathway has been implicated in the developing retina, where the inhibition of Notch has been shown to skew the proportion of different retinal neuronal cell types. Although functional knockout studies have allowed us to characterize some of the roles of Notch in the retina, low protein levels have made it difficult to characterize the location of Notch receptors and ligands in neuronal tissue. Here we sought to characterize the localization of the Notch signalling pathway components in both the developing and the adult mouse retina. Using RT-PCR we were able to show the presence of mRNA for Notch receptors, ligands, and DNA binding cofactors for the Notch intracellular domain, CBF1, throughout postnatal development as well as in the adult retina. In situ hybridization confirmed the presence of Notch1, Notch2, and CBF1 mRNA in the embryonic (E14.5) and early postnatal (P1.5) retina similar to what has been reported in earlier studies, but in the adult retina (P40), levels were below detection. To further explore the role of Notch in the adult retina we used two transgenic mouse reporter models in which a Notch responsive element directs the expression of EGFP or Venus. In the adult retina of the NTR line (Tg(Cp-EGFP)25Gaia/J) reporter expression was detected in rod ON and cone type 2 OFF bipolar cells, as well as in a subset of both amacrine and ganglion cells. In the CBFRE:H2B-Venus line adult reporter expression was detected in photoreceptors, and a large proportion of both amacrine and ganglion cells. Together this data supports the conclusion that Notch is expressed and actively signalling in the retina throughout development and possibly in the adult retina, although below levels of in situ hybridization detection. These results represent the possibility of a previously unknown role for Notch in the adult retina. Advisors/Committee Members: Chow, Robert Lewis (supervisor).

Subjects/Keywords: retina; notch

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APA (6^th Edition):

Ronellenfitch, K. (2013). Investigating the possibility of Notch signalling in the adult retina. (Masters Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/4858

Chicago Manual of Style (16^th Edition):

Ronellenfitch, Kara. “Investigating the possibility of Notch signalling in the adult retina.” 2013. Masters Thesis, University of Victoria. Accessed December 14, 2019. http://hdl.handle.net/1828/4858.

MLA Handbook (7^th Edition):

Ronellenfitch, Kara. “Investigating the possibility of Notch signalling in the adult retina.” 2013. Web. 14 Dec 2019.

Vancouver:

Ronellenfitch K. Investigating the possibility of Notch signalling in the adult retina. [Internet] [Masters thesis]. University of Victoria; 2013. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/1828/4858.

Council of Science Editors:

Ronellenfitch K. Investigating the possibility of Notch signalling in the adult retina. [Masters Thesis]. University of Victoria; 2013. Available from: http://hdl.handle.net/1828/4858

Universidade Estadual de Campinas

5. Duarte, Mario Antonio. Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves .

Degree: 2000, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252

Subjects/Keywords: Retina

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APA (6^th Edition):

Duarte, M. A. (2000). Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves . (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Duarte, Mario Antonio. “Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves .” 2000. Thesis, Universidade Estadual de Campinas. Accessed December 14, 2019. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Duarte, Mario Antonio. “Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves .” 2000. Web. 14 Dec 2019.

Vancouver:

Duarte MA. Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves . [Internet] [Thesis]. Universidade Estadual de Campinas; 2000. [cited 2019 Dec 14]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Duarte MA. Uma tecnica para o estudo do sinal optico intrinseco da depressão alastrante em retina de aves . [Thesis]. Universidade Estadual de Campinas; 2000. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/261252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Hernandez Matas, Carlos. Retinal image registration through 3D eye modelling and pose estimation.

Degree: 2017, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/42160

►

The in vivo assessment of small vessels can promote accurate diagnosis and progression monitoring of diseases related to vasculopathy, such as hypertension and diabetes. Given… (more)

▼

The in vivo assessment of small vessels can promote accurate diagnosis and progression monitoring of diseases related to vasculopathy, such as hypertension and diabetes. Given that the human eye retina contains small vessels that can be directly imaged via fundoscopy, the analysis of retinal structures becomes very important for non-invasive approaches. This is also important for the diagnosis of illnesses that affect eyesight, such as macular edema, age-related macular degeneration or glaucoma. This analysis can be greatly facilitated by accurate retinal image registration.Image registration is applied upon a pair of images, the reference and the test image. The goal is to warp the test image so that it images retinal points at the same 2D locations as the reference image. This is a challenging task, mainly for two reasons. The first is related to the perspective distortions due to the curved shape of the retina and change of the camera pose relative to the eye between image acquisitions. The second relates to potential changes in the retina that occur due to retinopathy between temporally distant image acquisitions. In addition, the nature of the application demands for high registration accuracy. Registration methods may benefit from knowledge of the type of images to be registered. In this work, we proposed a registration framework that simultaneously estimates the relative pose of the cameras that acquired the retinal images as well as the shape and the pose of the eye. The proposed framework is evaluated quantitatively and is shown to outperform state-of-the-art methods. In the context of this work, we also developed a set of tools for generating realistic 3D eye models. These tools were used to render synthetic retinal image pairs, utilized for testing and evaluating the proposed registration approach. Additionally, FIRE, a dataset comprised of pairs of real retinal images has been compiled and made publicly available. FIRE consists of three types of images, each one covering different challenges in retinal image registration. To enable the experimental, quantitative evaluation of the accuracy of a registration method, FIRE is annotated with ground truth point correspondences. In this work, we also explored the suitability of the proposed registration framework for applications such as longitudinal studies, image mosaicing and super resolution. Additionally, the fitness of the framework for performing eye shape estimation is studied. Pertinent experiments show encouraging results as well as ample room for further improvement.

Η μελέτη των λεπτών αιμοφόρων αγγείων μπορεί να βοηθήσει την ακριβή διάγνωση και την παρακολούθηση νόσων που σχετίζονται με αγγειοπάθεια, όπως η υπέρταση και ο διαβήτης. Η ευκολία απεικόνισης τέτοιων αγγείων στον αμφιβληστροειδή χιτώνα μέσω βυθοσκόπισης καθιστά την ανάλυση των δομικών χαρακτηριστικών του ιδιαίτερα σημαντική. Η ανάλυση αυτή είναι επίσης σημαντική για τη διάγνωση ασθενειών που επηρεάζουν την όραση, όπως το οίδημα της ωχράς κηλίδας, η ηλικιακή εκφύλιση της ωχράς κηλίδας…

Subjects/Keywords: Αντιστοίχιση; Retina

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APA (6^th Edition):

Hernandez Matas, C. (2017). Retinal image registration through 3D eye modelling and pose estimation. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/42160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hernandez Matas, Carlos. “Retinal image registration through 3D eye modelling and pose estimation.” 2017. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed December 14, 2019. http://hdl.handle.net/10442/hedi/42160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hernandez Matas, Carlos. “Retinal image registration through 3D eye modelling and pose estimation.” 2017. Web. 14 Dec 2019.

Vancouver:

Hernandez Matas C. Retinal image registration through 3D eye modelling and pose estimation. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2017. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10442/hedi/42160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hernandez Matas C. Retinal image registration through 3D eye modelling and pose estimation. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2017. Available from: http://hdl.handle.net/10442/hedi/42160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. González del Pozo, María. Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados.

Degree: 2014, Universidad de Sevilla

URL: http://hdl.handle.net/11441/23909

► Diagnosticar genéticamente a las familias afectas de alguna de las distrofias hereditarias de retina (DHR) es, desde el punto de vista del genetista, una tarea… (more)

Subjects/Keywords: Retina; Ojo

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APA (6^th Edition):

González del Pozo, M. (2014). Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados. (Thesis). Universidad de Sevilla. Retrieved from http://hdl.handle.net/11441/23909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

González del Pozo, María. “Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados.” 2014. Thesis, Universidad de Sevilla. Accessed December 14, 2019. http://hdl.handle.net/11441/23909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

González del Pozo, María. “Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados.” 2014. Web. 14 Dec 2019.

Vancouver:

González del Pozo M. Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados. [Internet] [Thesis]. Universidad de Sevilla; 2014. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/11441/23909.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

González del Pozo M. Aproximación genómica al diagnóstico genético de las distrofias hereditarias de retina y búsqueda de nuevos genes relacionados. [Thesis]. Universidad de Sevilla; 2014. Available from: http://hdl.handle.net/11441/23909

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Notre Dame

8. Sean C. Kassen. Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>.

Degree: PhD, Biological Sciences, 2008, University of Notre Dame

URL: https://curate.nd.edu/show/qn59q239w5t

► The zebrafish retina is an excellent model to study the molecular basis of neural cell regeneration. Dark-treated albino zebrafish exposed to intense light undergo… (more)

▼ The zebrafish retina is an excellent model to study the molecular basis of neural cell regeneration. Dark-treated albino zebrafish exposed to intense light undergo rod and cone photoreceptor apoptosis, which triggers MÌÄå_ller glia proliferation and the generation of neuronal progenitor cells. Next, multiple neuronal progenitor cells will either migrate to the outer nuclear layer and regenerate lost rods and cones or will remain in the inner nuclear layer to repopulate lost Müller glia. To identify candidate genes encode critical proteins required during photoreceptor regeneration, I performed a time course microarray of six time points representing different cellular events during the regeneration response. qRT-PCR verified the expression profiles for selected genes in the microarray data set. To examine genes involved in Müller glial cell proliferation and progenitor cell differentiation, I performed temporal and functional gene cluster analysis. I selected three genes for further analysis: i) Stat3, which functions through the Jak/Stat pathway, ii) CNTF, a growth factor that is known to activate the Jak/Stat pathway, and iii) Olig2, a transcription factor that regulates neuron and glial cell fates. Immunoblots verified increased total and activated Stat3 protein expression during the time course. Immunolocalization demonstrated increased Stat3 expression in Müller glial cells by 31 hours, and some Stat3-positive Müller glial cells expressed PCNA. To determine protein function during regeneration, I electroporated morpholinos into the adult retina to knockdown expression of target proteins. Stat3 knockdown significantly reduced the number of PCNA-labeled Müller glial cells during the light treatment, which demonstrated a role for Stat3 during light-induced retinal regeneration. Intravitreal CNTF injections suppressed light-induced photoreceptor apoptosis. Injection of CNTF into the undamaged zebrafish eye induced Stat3 expression in Müller cells, and Müller glia proliferation. However, knockdown of Stat3 in the CNTF-injected undamaged eye still induced Müller glia proliferation, which demonstrates CNTF’s mode of action is independent of Stat3. These data suggest Stat3 and CNTF possess independent roles in the damaged and undamaged zebrafish retina. Olig2 was expressed in dedifferentiated Müller glia and INL neuronal progenitor cells between 51 and 96 hrs of light treatment. Electroporation of anti-olig2 morpholinos knocked down Olig2 during zebrafish retinal regeneration. However, knockdown of Olig2 did not effect either cell proliferation, migration, or photoreceptor cell differentiation. Advisors/Committee Members: David Hyde, Committee Chair, Kevin Vaughan, Committee Member, Joe OTousa, Committee Member, Lei Li, Committee Member.

Subjects/Keywords: retina

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APA (6^th Edition):

Kassen, S. C. (2008). Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>. (Doctoral Dissertation). University of Notre Dame. Retrieved from https://curate.nd.edu/show/qn59q239w5t

Chicago Manual of Style (16^th Edition):

Kassen, Sean C.. “Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>.” 2008. Doctoral Dissertation, University of Notre Dame. Accessed December 14, 2019. https://curate.nd.edu/show/qn59q239w5t.

MLA Handbook (7^th Edition):

Kassen, Sean C.. “Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>.” 2008. Web. 14 Dec 2019.

Vancouver:

Kassen SC. Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>. [Internet] [Doctoral dissertation]. University of Notre Dame; 2008. [cited 2019 Dec 14]. Available from: https://curate.nd.edu/show/qn59q239w5t.

Council of Science Editors:

Kassen SC. Characterization of Light-Induced Zebrafish Retinal Regeneration and the Role of Stat3, CNTF, and Olig2 During Light-Induced Zebrafish Retinal Regeneration</h1>. [Doctoral Dissertation]. University of Notre Dame; 2008. Available from: https://curate.nd.edu/show/qn59q239w5t

University of Adelaide

9. Sosula, Leo. The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer.

Degree: 1969, University of Adelaide

URL: http://hdl.handle.net/2440/20416

Subjects/Keywords: Retina.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sosula, L. (1969). The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/20416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sosula, Leo. “The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer.” 1969. Thesis, University of Adelaide. Accessed December 14, 2019. http://hdl.handle.net/2440/20416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sosula, Leo. “The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer.” 1969. Web. 14 Dec 2019.

Vancouver:

Sosula L. The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer. [Internet] [Thesis]. University of Adelaide; 1969. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/2440/20416.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sosula L. The structure and function of the rat retina with particular reference to the acetylcholinesterase system in the inner plexiform layer. [Thesis]. University of Adelaide; 1969. Available from: http://hdl.handle.net/2440/20416

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

10. Kobamoto, Naotada, 1940-. The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes.

Degree: PhD, 1970, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:35281

Subjects/Keywords: Retina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kobamoto, Naotada, 1. (1970). The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:35281

Chicago Manual of Style (16^th Edition):

Kobamoto, Naotada, 1940-. “The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes.” 1970. Doctoral Dissertation, Michigan State University. Accessed December 14, 2019. http://etd.lib.msu.edu/islandora/object/etd:35281.

MLA Handbook (7^th Edition):

Kobamoto, Naotada, 1940-. “The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes.” 1970. Web. 14 Dec 2019.

Vancouver:

Kobamoto, Naotada 1. The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes. [Internet] [Doctoral dissertation]. Michigan State University; 1970. [cited 2019 Dec 14]. Available from: http://etd.lib.msu.edu/islandora/object/etd:35281.

Council of Science Editors:

Kobamoto, Naotada 1. The effect of temperature on the biphasic photopotentials of all-trans-retinal bimolecular lipid membranes. [Doctoral Dissertation]. Michigan State University; 1970. Available from: http://etd.lib.msu.edu/islandora/object/etd:35281

Universidad de Valladolid

11. Martínez Matesanz, Cristina Beatriz. Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios.

Degree: 2010, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/846

► Se ha diseñado un dispositivo basado en un sistema de doble visión maxwelliana, con una resolución temporal del orden del milisegundo y resolución espacial del… (more)

Subjects/Keywords: Luminancia; Retina

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APA (6^th Edition):

Martínez Matesanz, C. B. (2010). Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martínez Matesanz, Cristina Beatriz. “Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios.” 2010. Thesis, Universidad de Valladolid. Accessed December 14, 2019. http://uvadoc.uva.es/handle/10324/846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martínez Matesanz, Cristina Beatriz. “Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios.” 2010. Web. 14 Dec 2019.

Vancouver:

Martínez Matesanz CB. Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios. [Internet] [Thesis]. Universidad de Valladolid; 2010. [cited 2019 Dec 14]. Available from: http://uvadoc.uva.es/handle/10324/846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martínez Matesanz CB. Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios. [Thesis]. Universidad de Valladolid; 2010. Available from: http://uvadoc.uva.es/handle/10324/846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

12. Pastor Idoate, Salvador. Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4.

Degree: 2015, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/16655

► Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreoretinopatía proliferante. Tesis elaborada bajo la modalidad… (more)

Subjects/Keywords: Retina-Desprendimiento

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APA (6^th Edition):

Pastor Idoate, S. (2015). Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/16655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pastor Idoate, Salvador. “Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4.” 2015. Thesis, Universidad de Valladolid. Accessed December 14, 2019. http://uvadoc.uva.es/handle/10324/16655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pastor Idoate, Salvador. “Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4.” 2015. Web. 14 Dec 2019.

Vancouver:

Pastor Idoate S. Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4. [Internet] [Thesis]. Universidad de Valladolid; 2015. [cited 2019 Dec 14]. Available from: http://uvadoc.uva.es/handle/10324/16655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pastor Idoate S. Genética en la inflamación, apoptosis y otras vías de muerte celular en el desprendimiento de retina y la vitreorretinopatía proliferante: Proyecto Retina-4. [Thesis]. Universidad de Valladolid; 2015. Available from: http://uvadoc.uva.es/handle/10324/16655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

13. Haines, Richard Foster. A study of retinal intensity gradients.

Degree: PhD, Department of Psychology, 1964, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:40718

Subjects/Keywords: Retina

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haines, R. F. (1964). A study of retinal intensity gradients. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:40718

Chicago Manual of Style (16^th Edition):

Haines, Richard Foster. “A study of retinal intensity gradients.” 1964. Doctoral Dissertation, Michigan State University. Accessed December 14, 2019. http://etd.lib.msu.edu/islandora/object/etd:40718.

MLA Handbook (7^th Edition):

Haines, Richard Foster. “A study of retinal intensity gradients.” 1964. Web. 14 Dec 2019.

Vancouver:

Haines RF. A study of retinal intensity gradients. [Internet] [Doctoral dissertation]. Michigan State University; 1964. [cited 2019 Dec 14]. Available from: http://etd.lib.msu.edu/islandora/object/etd:40718.

Council of Science Editors:

Haines RF. A study of retinal intensity gradients. [Doctoral Dissertation]. Michigan State University; 1964. Available from: http://etd.lib.msu.edu/islandora/object/etd:40718

University of Hong Kong

14. 王可; Wang, Ke. Exploration of drug therapy in mouse models of human retinal diseases.

Degree: PhD, 2015, University of Hong Kong

URL: Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370

►

Retinitis pigmentosa (RP) is a series of inherited retinal degenerative diseases mostly caused by the gene mutations in rod photoreceptors, which lead to the primary… (more)

▼

Retinitis pigmentosa (RP) is a series of inherited retinal degenerative diseases mostly caused by the gene mutations in rod photoreceptors, which lead to the primary loss of rod photoreceptors, and the secondary loss of cone photoreceptors. More than 1.5 million people worldwide lose their sight every year as a result of RP disorder. RP is a hereditary disease with complex causes, there are currently no ideal treatments that are either against primary gene mutations or against the secondary neuronal degeneration. Therapies that aim to preserve photoreceptor function may represent an effective alternative for improving the quality of life of many RP patients. The main focus of this thesis was to investigate the pathological mechanism of RP and to explore possible therapeutic strategies for it. Although the mechanisms of photoreceptor death remain elusive in RP, multiple mechanisms are suggested to have a role in photoreceptor death. To confirm the involvement of multiple pathways in RP, we systemically applied three multi-target iron-chelator based compounds: VK28, M30, VAR10303and one multi-target traditional Chinese medicine LBP (Lycium barbarum polysaccharides)to the rd10 mouse model of RP. The effectiveness of these drugs was evaluated by morphological, electrophysiological, behavioral and molecular biological analysis. We found thatVK28, M30, VAR10303and LBP appeared to have both short-term and long-term neuroprotective effects on photoreceptor cell. We further identified that these compounds exerted their effects through anti-apoptotic, antioxidant and anti-inflammatory mechanisms. The findings provided more evidence on the involvement of multiple mechanisms in photoreceptor degeneration of RP, suggesting a multi-target drug therapy is more sufficient than a single-targeted manipulation in protecting photoreceptors from degeneration in RP treatment. Neuroinflammation is suggested to be involved in pathology of glaucoma, but the mechanisms regulating microglia activation are not yet clear. We thus investigated the mechanisms underlying microglia activation in a mouse model of glaucoma. We found that microglia activation played a pathogenic role in AOH-caused retinal ganglion cell (RGC).We also demonstrated that chemokine receptorCX3CR1 in microglia played an important role in regulating microglia activation. Our findings indicate that suppressing neuroinflammation might be a therapeutic option for improving RGC survival in patients with glaucoma.

published_or_final_version

Biomedical Sciences

Doctoral

Doctor of Philosophy

Subjects/Keywords: Retina - Diseases - Treatment; Retina - Diseases - Animal models

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APA (6^th Edition):

王可; Wang, K. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Doctoral Dissertation). University of Hong Kong. Retrieved from Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370

Chicago Manual of Style (16^th Edition):

王可; Wang, Ke. “Exploration of drug therapy in mouse models of human retinal diseases.” 2015. Doctoral Dissertation, University of Hong Kong. Accessed December 14, 2019. Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370.

MLA Handbook (7^th Edition):

王可; Wang, Ke. “Exploration of drug therapy in mouse models of human retinal diseases.” 2015. Web. 14 Dec 2019.

Vancouver:

王可; Wang K. Exploration of drug therapy in mouse models of human retinal diseases. [Internet] [Doctoral dissertation]. University of Hong Kong; 2015. [cited 2019 Dec 14]. Available from: Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370.

Council of Science Editors:

王可; Wang K. Exploration of drug therapy in mouse models of human retinal diseases. [Doctoral Dissertation]. University of Hong Kong; 2015. Available from: Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370

15. Kobayashi Gamboa, Jorge Fernando. Degeneraciones predisponentes de roturas retinianas en el ojo contralateral de los pacientes con desprendimiento de retina regmatógeno.

Degree: 2014, National University of San Marcos

URL: http://cybertesis.unmsm.edu.pe/handle/cybertesis/10974

► Determina la proporción de ojos sanos con degeneraciones predisponentes de roturas retinianas del total de pacientes con desprendimiento de retina regmatógeno en el ojo contra… (more)

Subjects/Keywords: Desprendimiento de la retina; Retina - Enfermedades

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APA (6^th Edition):

Kobayashi Gamboa, J. F. (2014). Degeneraciones predisponentes de roturas retinianas en el ojo contralateral de los pacientes con desprendimiento de retina regmatógeno. (Thesis). National University of San Marcos. Retrieved from http://cybertesis.unmsm.edu.pe/handle/cybertesis/10974

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kobayashi Gamboa, Jorge Fernando. “Degeneraciones predisponentes de roturas retinianas en el ojo contralateral de los pacientes con desprendimiento de retina regmatógeno.” 2014. Thesis, National University of San Marcos. Accessed December 14, 2019. http://cybertesis.unmsm.edu.pe/handle/cybertesis/10974.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kobayashi Gamboa, Jorge Fernando. “Degeneraciones predisponentes de roturas retinianas en el ojo contralateral de los pacientes con desprendimiento de retina regmatógeno.” 2014. Web. 14 Dec 2019.

Vancouver:

Kobayashi Gamboa JF. Degeneraciones predisponentes de roturas retinianas en el ojo contralateral de los pacientes con desprendimiento de retina regmatógeno. [Internet] [Thesis]. National University of San Marcos; 2014. [cited 2019 Dec 14]. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/10974.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kobayashi Gamboa JF. Degeneraciones predisponentes de roturas retinianas en el ojo contralateral de los pacientes con desprendimiento de retina regmatógeno. [Thesis]. National University of San Marcos; 2014. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/10974

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

16. Sukumaran, Sujita. Analysis of photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 intraflagellar transport mutants.

Degree: 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-3116

► Vertebrate photoreceptors are polarized cells that consist of a specialized sensory structure termed the outer segment required for phototransduction and an inner segment that contains… (more)

▼ Vertebrate photoreceptors are polarized cells that consist of a specialized sensory structure termed the outer segment required for phototransduction and an inner segment that contains the cellular organelles. Proteins synthesized in the inner segment are transported to the outer segment via a connecting cilium by a process called Intraflagellar Transport (IFT). The IFT mechanism refers to the movement of a multisubunit complex along the flagellar axoneme, and mutations in some IFT components cause retinal degeneration. To better understand the role of IFT in early photoreceptor development, we studied zebrafish with mutations in genes encoding three specific subunits of the IFT particle: IFT57, IFT88 and IFT172. These mutants exhibit photoreceptor defects by five days post fertilization (dpf); however, it is not known whether outer segment formation initiates at earlier time points and then degeneration occurs or if outer segments never form at all. To understand this, we performed transmission electron microscopy to study the ultrastructure of photoreceptors at 60, 72 and 96 hours post fertilization (hpf). At 60 hpf, developing outer segments were seen in IFT57 mutant and wild type embryos, however, disorganized membranous structures were observed in IFT88 and IFT172 mutants. At 72 hpf, the number of outer segments in the IFT57 mutants was reduced by 88% when compared to wild type, indicating a defect in initiation of outer segment formation. By 96 hpf we see a reduction in both outer segment length and number in IFT57 mutants. In comparison, the IFT88 and IFT172 mutants do not grow outer segments at any time point. To complement our ultrastructural analysis, we performed immunohistochemistry to understand cell morphology and protein trafficking in these mutants. Zpr1, a marker for cone morphology, showed the presence of normal cones initially that began to degenerate at later time points. Immunohistochemistry with rhodopsin, a phototransduction protein that localizes to the outer segment, revealed that rhodopsin was mislocalized in all the three mutants by 96 hpf. Connecting cilia labeled with acetylated tubulin were highly reduced in IFT57 mutants whereas none were observed in IFT88 and IFT172 mutants. Together these data indicate that IFT57 is required for maintenance and growth of outer segments whereas IFT88 and IFT172 are required for initiating outer segment formation. Advisors/Committee Members: Perkins, Brian D. (advisor), Gumienny, Tina L. (committee member), Riley, Bruce (committee member).

Subjects/Keywords: Retina; Intraflagellar transport

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sukumaran, S. (2009). Analysis of photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 intraflagellar transport mutants. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-3116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sukumaran, Sujita. “Analysis of photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 intraflagellar transport mutants.” 2009. Thesis, Texas A&M University. Accessed December 14, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-3116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sukumaran, Sujita. “Analysis of photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 intraflagellar transport mutants.” 2009. Web. 14 Dec 2019.

Vancouver:

Sukumaran S. Analysis of photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 intraflagellar transport mutants. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sukumaran S. Analysis of photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 intraflagellar transport mutants. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

17. Slick, Nathalie Rose. Ocular manifestations of chronic traumatic encephalopathy.

Degree: MS, Medical Sciences, 2014, Boston University

URL: http://hdl.handle.net/2144/14360

► Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that is characterized by a tauopathy in the form of aggregates of hyperphosphorylated tau throughout the… (more)

Subjects/Keywords: Neurosciences; CTE; Retina

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APA (6^th Edition):

Slick, N. R. (2014). Ocular manifestations of chronic traumatic encephalopathy. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14360

Chicago Manual of Style (16^th Edition):

Slick, Nathalie Rose. “Ocular manifestations of chronic traumatic encephalopathy.” 2014. Masters Thesis, Boston University. Accessed December 14, 2019. http://hdl.handle.net/2144/14360.

MLA Handbook (7^th Edition):

Slick, Nathalie Rose. “Ocular manifestations of chronic traumatic encephalopathy.” 2014. Web. 14 Dec 2019.

Vancouver:

Slick NR. Ocular manifestations of chronic traumatic encephalopathy. [Internet] [Masters thesis]. Boston University; 2014. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/2144/14360.

Council of Science Editors:

Slick NR. Ocular manifestations of chronic traumatic encephalopathy. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14360

University of New South Wales

18. Yin, Shijie. Computational model of the retinal network.

Degree: Graduate School of Biomedical Engineering, 2012, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true

► The loss of vision through degenerative retinal diseases is a tragic human condition affecting millions around the world. Development of a visual prosthetic device hoping… (more)

▼ The loss of vision through degenerative retinal diseases is a tragic human condition affecting millions around the world. Development of a visual prosthetic device hoping to restore vision to these patients is underway by electrically stimulating the retinal ganglion cells of the retina with nearby electrodes. These neurons responsible for the transmission of electrical signals to the visual cortex of the brain are thought to be largely intact even in patients who have been blind for many years. The pursuit of eliciting useful vision faces a great number of challenges in both device design and stimulation strategy. Powerful tools such as mathematical models can assist by redirecting the focus of implant and stimulus algorithm design to critical areas.Previous retinal models primarily focused on either a compartmental approach employing active descriptions of cellular membrane mechanisms or discrete network models. However, the extent of spatial activation of the retina on a large scale is not considered, nor are the effects of the network in shaping spiking activity taken into account in a continuum sense. The development of a novel pseudo-bidomain model incorporating presynaptic inputs from deeper retinal neurons will be presented in this thesis. Model parameters are tuned to reflect feasible responses to epiretinal stimulation and validated against suprachoroidal stimulation and various electrode and stimulus configurations.Simulation findings suggest a threshold charge density for activation of 50 ± 2 µC/cm2 for epiretinal stimulation with a disc electrode of 200 µm radius and a rectangular cathodic stimulus of 100 µs pulse width. For suprachoroidal stimulation, this was observed to be 137 ± 2 µC/cm2. Inclusion of presynaptic inputs elicited stimulus-locked and network driven action potentials. For epiretinal stimulation presence of early and late onset action potentials were observed with latencies of 0.3 and 7 ms respectively with a charge density of 398 - 438 µC/cm2. In comparison suprachoroidal stimulation displayed an earlier network driven response (6.4 ms) at a lower charge density of 223 - 231 µC/cm2. These near threshold and latency findings were consistent with published works and present a novel approach to examining retinal activation in a spatiotemporal setting.

Subjects/Keywords: Stimulation; Retina; Model

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yin, S. (2012). Computational model of the retinal network. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Yin, Shijie. “Computational model of the retinal network.” 2012. Doctoral Dissertation, University of New South Wales. Accessed December 14, 2019. http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Yin, Shijie. “Computational model of the retinal network.” 2012. Web. 14 Dec 2019.

Vancouver:

Yin S. Computational model of the retinal network. [Internet] [Doctoral dissertation]. University of New South Wales; 2012. [cited 2019 Dec 14]. Available from: http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true.

Council of Science Editors:

Yin S. Computational model of the retinal network. [Doctoral Dissertation]. University of New South Wales; 2012. Available from: http://handle.unsw.edu.au/1959.4/52473 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11146/SOURCE01?view=true

Harvard University

19. Liu, Jinyue. Molecular Determinants of Dendritic Patterning in the Mammalian Retina.

Degree: PhD, 2017, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224

►

The architecture of dendritic arbors is a critical element in neuronal connectivity and function, influencing partner choice, synaptic wiring and computational properties. Unraveling core principles… (more)

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The architecture of dendritic arbors is a critical element in neuronal connectivity and function, influencing partner choice, synaptic wiring and computational properties. Unraveling core principles in dendritic patterning is thus an outstanding objective in neurodevelopment research. Here, I report my efforts towards this goal, utilizing the morphological diversity of retinal ganglion cells (RGCs) in mammalian retina to elucidate the cellular and molecular logic behind dendritic patterning. To begin, I characterized how RGCs belonging to one type, called J-RGC, coordinate dendritic patterning across time and space to produce a stereotyped morphology. I showed that ventral asymmetry of J-RGC dendrites develops in a protracted dorsoventral wave while their lamination within the inner plexiform layer (IPL) develops rapidly in a centrifugal wave. Each ventrally-asymmetric, lamina-restricted arbor bears an asymmetric distribution of inhibitory synapses, the formation of which, surprisingly, lags behind that of excitatory synapses. Thus, distinct mechanisms operate in different dimensions of J-RGC dendritic patterning to generate the appropriate substrate for highly specific modes of synaptogenesis. Next, I present work on the intrinsic control of dendritic patterning in RGCs like J-RGCs. Using transcriptomic profiling with molecular, transgenic and spatial mosaic analyses, I discovered that the transcription factor T-box Brain 1 (Tbr1) is selectively expressed by J-RGCs and three other RGC types. All of them send dendrites to the outer half of the IPL. Using loss- and gain-of-function approaches, I demonstrated that Tbr1 is both necessary and instructive for laminar specification of RGC dendrites. Therefore, Tbr1 is a transcriptional determinant of laminar identity for RGC dendrites. Finally, I describe the roles of cell-surface molecules in Tbr1-driven, type-specific dendritic patterning. I showed that a classical cadherin, Cdh8, and a growth factor receptor, Sorcs3, are localized to J-RGC dendrites, regulated by Tbr1 and capable of affecting lamination by themselves. Thus Tbr1 acts in part via Cdh8 and Sorcs3 to specify the laminar identity of J-RGC dendrites. My work puts forth the concept that a single transcriptional determinant can drive a common dendritic lamination pattern presented by different RGC types. Each determinant can then employ multiple and type-specific mediators to establish key aspects of that lamination program.

Medical Sciences

Advisors/Committee Members: Sanes, Joshua (advisor), Goodrich, Lisa (committee member), Arlotta, Paola (committee member), Mason, Carol (committee member).

Subjects/Keywords: Retina; Dendritic patterning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, J. (2017). Molecular Determinants of Dendritic Patterning in the Mammalian Retina. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224

Chicago Manual of Style (16^th Edition):

Liu, Jinyue. “Molecular Determinants of Dendritic Patterning in the Mammalian Retina.” 2017. Doctoral Dissertation, Harvard University. Accessed December 14, 2019. http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224.

MLA Handbook (7^th Edition):

Liu, Jinyue. “Molecular Determinants of Dendritic Patterning in the Mammalian Retina.” 2017. Web. 14 Dec 2019.

Vancouver:

Liu J. Molecular Determinants of Dendritic Patterning in the Mammalian Retina. [Internet] [Doctoral dissertation]. Harvard University; 2017. [cited 2019 Dec 14]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224.

Council of Science Editors:

Liu J. Molecular Determinants of Dendritic Patterning in the Mammalian Retina. [Doctoral Dissertation]. Harvard University; 2017. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41140224

Rutgers University

20. Pavlou, Michael J., 1989-. A mechanics based analytical model of vitreous motion and vitreous detachment in the human eye when subjected to saccadic movement.

Degree: PhD, Mechanical and Aerospace Engineering, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57674/

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In the human eye, the detachment behavior of the vitreous cortex from the sensory retina is clinically significant as this pathology is highly correlated with… (more)

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In the human eye, the detachment behavior of the vitreous cortex from the sensory retina is clinically significant as this pathology is highly correlated with rhegmatogenous retinal detachment, a serious eye condition that can result in vision loss. A mechanics based mathematical model for vitreo-retinal detachment in the human eye when subjected to saccadic eye motion is presented in this dissertation. The problem is formulated as a two-dimensional propagating boundary value viscoelasticity problem in the calculus of variations. This formulation yields the governing equations of the vitreous body, boundary conditions, matching conditions and a transversality condition which, in turn, yields the detachment criterion during a saccade. The first part of the dissertation studies a constrained two-dimensional model where only the dominant motion of the vitreous is considered. Closed form analytical solutions of the coupled set of partial differential equations are obtained via modal analysis of a vibrating two-dimensional continuum with non-periodic loading. Results of numerical simulations are presented, ultimately revealing the evolution of the detachment of the vitreo-retinal interface. In the second part of the dissertation, fully two-dimensional motion of the vitreous is considered. A semi-analytical solution is obtained via the Rayleigh-Ritz method in combination with modal analysis. Results are compared to the constrained two-dimensional model, as well as to clinically observed data and previously published experimental and numerical studies. The material properties of the human vitreous are both difficult to study, and change significantly with age and other factors. The effects of these properties on the motion of the vitreous and the detachment behavior of the vitreo-retinal interface are studied. The results of the present study indicate that if a saccade is large enough to cause further detachment of the vitreous from the retina, then the detachment will progress until it reaches a point of abnormal vitreo-retinal adhesion.

Advisors/Committee Members: Bottega, William J (chair), Benaroya, Haym (internal member), Baruh, Haim (internal member), Fine, Howard (outside member), School of Graduate Studies.

Subjects/Keywords: Eye – Physiology; Retina

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APA (6^th Edition):

Pavlou, Michael J., 1. (2018). A mechanics based analytical model of vitreous motion and vitreous detachment in the human eye when subjected to saccadic movement. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57674/

Chicago Manual of Style (16^th Edition):

Pavlou, Michael J., 1989-. “A mechanics based analytical model of vitreous motion and vitreous detachment in the human eye when subjected to saccadic movement.” 2018. Doctoral Dissertation, Rutgers University. Accessed December 14, 2019. https://rucore.libraries.rutgers.edu/rutgers-lib/57674/.

MLA Handbook (7^th Edition):

Pavlou, Michael J., 1989-. “A mechanics based analytical model of vitreous motion and vitreous detachment in the human eye when subjected to saccadic movement.” 2018. Web. 14 Dec 2019.

Vancouver:

Pavlou, Michael J. 1. A mechanics based analytical model of vitreous motion and vitreous detachment in the human eye when subjected to saccadic movement. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2019 Dec 14]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57674/.

Council of Science Editors:

Pavlou, Michael J. 1. A mechanics based analytical model of vitreous motion and vitreous detachment in the human eye when subjected to saccadic movement. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57674/

Rutgers University

21. Rayaji, Rameshwari, 1990-. Effect of Top2b inhibition on cadherin expression in developing chicken retina.

Degree: MS, Biomedical Engineering, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51439/

► Retinal development involves defined guidance of neuronal axons to their destined cells through cell adhesion molecules, by compilation of cell-cell connections at synapses. Cell adhesion… (more)

▼ Retinal development involves defined guidance of neuronal axons to their destined cells through cell adhesion molecules, by compilation of cell-cell connections at synapses. Cell adhesion molecules promote oriented axonal outgrowth and help in target synaptic specificity to maintain histoarchitecture of retina. Cell adhesion molecules like cadherins are the products of expression of long genes >200 kilobases of genomic DNA. Topoisomerase II beta (Top2b) involved in modulating DNA supercoiling by catalyzing the double strand breaks and passing the stands through one another. Top2b is pervasively expressed in all terminally differentiated cells and participates in gene transcription. Recent studies have shown that Top2b facilitates the expression of long genes. However, its particular role in transcription of cadherins and effect on organization of retinal cells such as retinal ganglion cells and horizontal cells remain unclear. In current study, the role of Top2b in expression of cadherin genes was analyzed in iii developing chick retina via immunohistochemistry and real-time PCR. Top2b function in developing retina was inhibited by injections of 500µM Top2b catalytic inhibitor (ICRF-193) into sub-retinal space at embryonic day 4 (E4). Retinal tissues were analyzed by immunohistochemistry using cell specific markers, e.g., Brn3a for ganglion cells, 4F2 for horizontal cells, and Tuj1 for neuronal processes at E6, E8, E10, and E12. We showed that inhibition of Top2b by ICRF-193 i) reduced the expression level of cadherin genes, e.g., N-cadherin (Cdh2), Cadherin-6B (Cad6B), Cadherin-7 (Cdh7), and Cadhrin-8 (Cdh8)in developing retina; ii)led to a disoriented cellular organization; and iii) delayed migration of RGCs and HCs. The results from immunohistochemistry were confirmed by quantitative real-time PCR (qRT-PCR). Results from qRT-PCR showed significant reduction in expression levels of cadherin genes, e.g., Cad6B and Cdh7 with an average fold reduction of 2.5 prominent at embryonic day 10 (E10) (p <0.02, p<0.006), respectively and Cdh8 with an average fold reduction of 4 prominent at embryonic day 8 (E8) (p <0.02), however expression of Cdh2 was not effected by Top2b inhibition at E6-E12. This study helps to understand the molecular basis of vertebrate retinal development via calcium-dependent intercellular cell adhesion molecules and revealed the vital role of Top2b in expression of cadherin genes. Advisors/Committee Members: Cai, Li (chair).

Subjects/Keywords: Cadherins; Retina – Growth

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rayaji, Rameshwari, 1. (2016). Effect of Top2b inhibition on cadherin expression in developing chicken retina. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51439/

Chicago Manual of Style (16^th Edition):

Rayaji, Rameshwari, 1990-. “Effect of Top2b inhibition on cadherin expression in developing chicken retina.” 2016. Masters Thesis, Rutgers University. Accessed December 14, 2019. https://rucore.libraries.rutgers.edu/rutgers-lib/51439/.

MLA Handbook (7^th Edition):

Rayaji, Rameshwari, 1990-. “Effect of Top2b inhibition on cadherin expression in developing chicken retina.” 2016. Web. 14 Dec 2019.

Vancouver:

Rayaji, Rameshwari 1. Effect of Top2b inhibition on cadherin expression in developing chicken retina. [Internet] [Masters thesis]. Rutgers University; 2016. [cited 2019 Dec 14]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51439/.

Council of Science Editors:

Rayaji, Rameshwari 1. Effect of Top2b inhibition on cadherin expression in developing chicken retina. [Masters Thesis]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51439/

Universidad de Valladolid

22. Kumar Singh, Amar. The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases.

Degree: 2013, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/4380

► Este trabajo se propone la utilización del potencial de diferenciación hacia células con fenotipo EPR que poseen las hAD‐MSCs, simultáneamente con sus beneficiosos efectos paracrinos… (more)

Subjects/Keywords: Retina-enfermedades; Oftalmología

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APA (6^th Edition):

Kumar Singh, A. (2013). The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/4380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kumar Singh, Amar. “The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases.” 2013. Thesis, Universidad de Valladolid. Accessed December 14, 2019. http://uvadoc.uva.es/handle/10324/4380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kumar Singh, Amar. “The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases.” 2013. Web. 14 Dec 2019.

Vancouver:

Kumar Singh A. The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases. [Internet] [Thesis]. Universidad de Valladolid; 2013. [cited 2019 Dec 14]. Available from: http://uvadoc.uva.es/handle/10324/4380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kumar Singh A. The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases. [Thesis]. Universidad de Valladolid; 2013. Available from: http://uvadoc.uva.es/handle/10324/4380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

23. Muñoz Cuéllar, Juan Manuel. Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá.

Degree: 2017, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/25770

► Introducción: Las distrofias retinianas son determinadas genéticamente e implican una gran variabilidad fenotípica y genotípica. En Iberoamérica hay poca literatura sobre sus aspectos fenotípicos, genotípicos… (more)

Subjects/Keywords: Retina-Enfermedades-Panamá

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Muñoz Cuéllar, J. M. (2017). Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/25770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Muñoz Cuéllar, Juan Manuel. “Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá.” 2017. Thesis, Universidad de Valladolid. Accessed December 14, 2019. http://uvadoc.uva.es/handle/10324/25770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Muñoz Cuéllar, Juan Manuel. “Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá.” 2017. Web. 14 Dec 2019.

Vancouver:

Muñoz Cuéllar JM. Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá. [Internet] [Thesis]. Universidad de Valladolid; 2017. [cited 2019 Dec 14]. Available from: http://uvadoc.uva.es/handle/10324/25770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Muñoz Cuéllar JM. Caracterización clínica y frecuencia de observación de enfermedades hereditarias de la retina en un estudio multicéntrico en Panamá. [Thesis]. Universidad de Valladolid; 2017. Available from: http://uvadoc.uva.es/handle/10324/25770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

24. Jones, Alicia R. Retinal mophology and intelligence.

Degree: MS, Kinesiology, 2018, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/101035

► Objective: To investigate the relationship between retinal morphometric measures and intellectual abilities among adults with overweight and obesity. Methods: Adults between 25-45 years (N=55, 38… (more)

Subjects/Keywords: Retina; IQ; OCT

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APA (6^th Edition):

Jones, A. R. (2018). Retinal mophology and intelligence. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/101035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, Alicia R. “Retinal mophology and intelligence.” 2018. Thesis, University of Illinois – Urbana-Champaign. Accessed December 14, 2019. http://hdl.handle.net/2142/101035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, Alicia R. “Retinal mophology and intelligence.” 2018. Web. 14 Dec 2019.

Vancouver:

Jones AR. Retinal mophology and intelligence. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2018. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/2142/101035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones AR. Retinal mophology and intelligence. [Thesis]. University of Illinois – Urbana-Champaign; 2018. Available from: http://hdl.handle.net/2142/101035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

25. Martínez Matesanz, Cristina Beatriz. Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios.

Degree: 2018, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/846

Subjects/Keywords: Luminancia; Retina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martínez Matesanz, C. B. (2018). Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martínez Matesanz, Cristina Beatriz. “Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios.” 2018. Thesis, Universidad de Valladolid. Accessed December 14, 2019. http://uvadoc.uva.es/handle/10324/846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martínez Matesanz, Cristina Beatriz. “Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios.” 2018. Web. 14 Dec 2019.

Vancouver:

Martínez Matesanz CB. Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios. [Internet] [Thesis]. Universidad de Valladolid; 2018. [cited 2019 Dec 14]. Available from: http://uvadoc.uva.es/handle/10324/846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martínez Matesanz CB. Diseño y puesta a punto de una técnica de medida de sensibilidad retiniana: Aplicación al estudio del comportamiento de la adaptación de retina periférica frente a campos luminosos estacionarios y transitorios. [Thesis]. Universidad de Valladolid; 2018. Available from: http://uvadoc.uva.es/handle/10324/846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

26. Takasaka, Iuuki, 1980-. Ensaio clínico aleatorizado de crioterapia intra-operatória versus fotocoagulação pós-operatória a laser para retinopexia na cirurgia de introflexão escleral .

Degree: 2012, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311824

► Resumo: Introdução: O descolamento de retina regmatogênico (DRR), uma das causas de cegueira, tem uma incidência anual de cerca de 6,3 - 17,9/100.000 habitantes na… (more)

▼ Resumo: Introdução: O descolamento de retina regmatogênico (DRR), uma das causas de cegueira, tem uma incidência anual de cerca de 6,3 - 17,9/100.000 habitantes na população mundial, e se não tratado pode levar a cegueira devido a degeneração das camadas retinianas. O uso de introflexão em conjunto com as adesões coriorretinianas em torno da rotura retiniana forma a base do tratamento para muitos DRR simples. A crioterapia realizada para retinopexia intra-operatoria tem sido implicada no desenvolvimento de pucker macular e vitreorretinopatia proliferativa. Eliminar a crioterapia da cirurgia convencional de introflexão poderia não afetar o resultado do sucesso anatômico e melhorar a recuperação visual. Objetivo: O objetivo primário deste ensaio clínico randomizado foi comparar a taxa de reaplicação retiniana e secundariamente os resultados da acuidade visual em pacientes com DRR que se submeteram a cirurgia de introflexão escleral e retinopexia com a crioterapia intra-operatória versus fotocoagulação a laser pós-operatório (um mês após a cirurgia). Método: É um ensaio clínico aleatorizado, mascarado, realizado em um único centro, composto por 86 pacientes submetidos à cirurgia de introflexão escleral. Os pacientes foram aleatorizados para serem submetidos à cirurgia de introflexão escleral e retinopexia com crioterapia intraoperatória (criopexia) ou retinopexia com fotocoagulação a laser pós operatória de 30 dias (laserpexia) após o procedimento. O desfecho primário foi avaliar a taxa de reaplicação retiniana no seguimento pós-operatório em 1 semana. Os desfechos secundários foram avaliar as taxas de reaplicação retiniana, as taxas de reoperação, as taxas de complicações pós-operatórias e recuperação da acuidade visual, em 1 mês e 6 meses de seguimento pós-operatório. Resultados: Foram incluídos 86 olhos de 86 pacientes a serem submetidos introflexão escleral. A amostra foi constituída de 43 pacientes pertencentes ao grupo laserpexia e 43 pacientes atribuídos ao grupo criopexia. Os dados demográficos foram semelhantes nos dois grupos. A taxa de sucesso anatômico em 1 semana, 1 mês e 6 meses foram semelhantes nos dois grupos, respectivamente, 93% (40 pacientes), 100% e 100% no grupo criopexia e 95,3% (41 pacientes), 100% e 100% no grupo da laserpexia (P, respectivamente, 0,5; 1,0 e 1,0). Três pacientes do grupo criopexia e 2 do laserpexia foram submetidos a uma cirurgia adicional (vitrectomia via pars plana) após a falha primária em 1 semana de seguimento. As complicações pós-operatórias foram semelhantes nos dois grupos, com exceção do edema de pálpebras. A recuperação visual foi mais lenta no grupo da crioterapia. A diferença na AV após 6 meses não foi significativa. Conclusão: Em pacientes com descolamento de retina regmatogênico sem complicações, ambas as técnicas de retinopexia mostraram resultados anatômico e funcional satisfatórios. A opção por laserpexia oferece recuperação visual mais rápida com menos complicações, porém requer uma segunda intervenção e maior custo em relação a criopexia; Abstract:… Advisors/Committee Members: Lira, Rodrigo Pessoa Cavalcanti, 1973- (advisor), Arieta, Carlos Eduardo Leite, 1956- (advisor), Cella, Wener Pssarinho (committee member), Vasconcellos, Jose Paulo Cabral de (committee member).

Subjects/Keywords: Descolamento de retina; Laser; Crioterapia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Takasaka, Iuuki, 1. (2012). Ensaio clínico aleatorizado de crioterapia intra-operatória versus fotocoagulação pós-operatória a laser para retinopexia na cirurgia de introflexão escleral . (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/311824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Takasaka, Iuuki, 1980-. “Ensaio clínico aleatorizado de crioterapia intra-operatória versus fotocoagulação pós-operatória a laser para retinopexia na cirurgia de introflexão escleral .” 2012. Thesis, Universidade Estadual de Campinas. Accessed December 14, 2019. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Takasaka, Iuuki, 1980-. “Ensaio clínico aleatorizado de crioterapia intra-operatória versus fotocoagulação pós-operatória a laser para retinopexia na cirurgia de introflexão escleral .” 2012. Web. 14 Dec 2019.

Vancouver:

Takasaka, Iuuki 1. Ensaio clínico aleatorizado de crioterapia intra-operatória versus fotocoagulação pós-operatória a laser para retinopexia na cirurgia de introflexão escleral . [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2019 Dec 14]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Takasaka, Iuuki 1. Ensaio clínico aleatorizado de crioterapia intra-operatória versus fotocoagulação pós-operatória a laser para retinopexia na cirurgia de introflexão escleral . [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

27. Tchernookova, Boriana Krassimirova. Characterization of Extracellular H+ Fluxes from Isolated Glia and Slices of the Vertebrate Retina.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21812

► Active glia-neuron interactions are crucial for the proper development and function of the nervous system. Bidirectional communication between neurons and glial cells has been shown… (more)

▼ Active glia-neuron interactions are crucial for the proper development and function of the nervous system. Bidirectional communication between neurons and glial cells has been shown to have modulatory effects on neuronal signaling. The exact mechanisms which glial cells employ to influence the behavior of neurons have not been fully understood. In the vertebrate retina, extracellular pH can act as a modulator of neuronal signaling by altering the activity of calcium channels, particularly on photoreceptor terminals. Experiments have demonstrated that when the pH of the extracellular medium is lowered to more acidic values, the calcium flux into photoreceptors is lessened. The exact cell type, which mediates these changes in extracellular pH, is still debatable with mounting evidence pointing to the role of horizontal cells in this process. This work presents evidence that retina Müller glial cells of tiger salamander are capable of mediating changes in extracellular proton concentration. Müller glia respond to extracellular ATP with a robust extracellular acidification measured with ion-selective microelectrodes. The mechanism through which these cells change the extracellular acidity involves the activation of membrane ATP receptors and the mobilization of intracellular signaling molecules with resulting intracellular calcium increases. The ATP-induced sustained acidifications are observed from isolated Müller glia as well as in retinal slices. Interestingly, Müller cells of the retinae of many other vertebrates tested, including Macaques and human, also respond to extracellular ATP through acidifications of the extracellular space, suggesting that this is a conserved and potentially physiologically important response. Müller cells respond to extracellular glutamate as well, but the changes in extracellular acidity are opposite of these evoked by ATP: glutamate induces Müller cell-mediated extracellular transient alkalinization, which seems to be due to the activity of membrane glutamate transporters. In slices, the initial transient alkalinization induced by glutamate is followed by a pronounced, sustained acidification, whose mechanism is independent of the glutamate transporters’ activity. This data suggest Müller glia could potentially play a role in extracellular proton modulation of neuronal activity in the vertebrate retina Advisors/Committee Members: Malchow, Robert P (advisor).

Subjects/Keywords: retina; glia; ATP; pH

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tchernookova, B. K. (2017). Characterization of Extracellular H+ Fluxes from Isolated Glia and Slices of the Vertebrate Retina. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21812

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tchernookova, Boriana Krassimirova. “Characterization of Extracellular H+ Fluxes from Isolated Glia and Slices of the Vertebrate Retina.” 2017. Thesis, University of Illinois – Chicago. Accessed December 14, 2019. http://hdl.handle.net/10027/21812.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tchernookova, Boriana Krassimirova. “Characterization of Extracellular H+ Fluxes from Isolated Glia and Slices of the Vertebrate Retina.” 2017. Web. 14 Dec 2019.

Vancouver:

Tchernookova BK. Characterization of Extracellular H+ Fluxes from Isolated Glia and Slices of the Vertebrate Retina. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10027/21812.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tchernookova BK. Characterization of Extracellular H+ Fluxes from Isolated Glia and Slices of the Vertebrate Retina. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/21812

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

28. Dreyer, Samuel. Design, Fabricate, and Test an in vitro System to Investigate Therapeutic Hypothermia in Porcine Eyes.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/22030

► Traumatic eye injuries are 4th in volume behind traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), and hearing loss for serious injuries among active duty… (more)

Subjects/Keywords: Therapeutic hypothermia; ischemia; retina; eye

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dreyer, S. (2017). Design, Fabricate, and Test an in vitro System to Investigate Therapeutic Hypothermia in Porcine Eyes. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dreyer, Samuel. “Design, Fabricate, and Test an in vitro System to Investigate Therapeutic Hypothermia in Porcine Eyes.” 2017. Thesis, University of Illinois – Chicago. Accessed December 14, 2019. http://hdl.handle.net/10027/22030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dreyer, Samuel. “Design, Fabricate, and Test an in vitro System to Investigate Therapeutic Hypothermia in Porcine Eyes.” 2017. Web. 14 Dec 2019.

Vancouver:

Dreyer S. Design, Fabricate, and Test an in vitro System to Investigate Therapeutic Hypothermia in Porcine Eyes. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10027/22030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dreyer S. Design, Fabricate, and Test an in vitro System to Investigate Therapeutic Hypothermia in Porcine Eyes. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

29. Ferreira, Thiago Vernetti. Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil.

Degree: 2012, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/61904

►

O estudo Elsa-Brasil visa à investigação de fatores de risco para saúde da população adulta, sendo realizado em seis estados brasileiros. Os participantes foram submetidos,… (more)

▼

O estudo Elsa-Brasil visa à investigação de fatores de risco para saúde da população adulta, sendo realizado em seis estados brasileiros. Os participantes foram submetidos, na linha de base, a diferentes exames, entre os quais a retinografia. A análise da retinografia foi realizada para identificar anormalidades de fundo de olho como retinopatia diabética, degeneração macular relacionada à idade, entre outros. Participantes com tais anomalias foram notificados em conformidade. O centro de leitura de retinografia tinha seis leitores certificados disponíveis para analisar as fotografias do fundo de olho. Os leitores foram treinados de acordo com a sua formação profissional prévia. Entre os oftalmologistas a padronização enfatizou a classificação de resultados anormais e estabelecimento dos resultados. Para estudantes de medicina, um mínimo de três meses de treinamento com um oftalmologista foi necessário antes de iniciar as leituras. O supervisor realizou controle periódico de qualidade das imagens no Centro de leitura de retinografia. No total, foram avaliadas mais de 40.000 imagens de fundo (cerca de quatro por participante). Análise de confiabilidade intra e interobservador foram realizadas para legibilidade das imagens e presença de achados anormais. Avaliaram-se as fotografias de fundo de olho de 10.648 participantes do estudo ELSA, com 52,8 ±9.2 anos, 53,5% eram mulheres e mais de 60% tinha iniciado ou concluído uma licenciatura. Os centros com maior número de participantes foram São Paulo, Minas Gerais, Rio Grande do Sul, Rio de Janeiro, Bahia e Espírito Santo, respectivamente. Cerca de 91% das imagens, tanto para olho direito como olho esquerdo, foram legíveis, 12% dos participantes apresentaram achados compatíveis com alteração ocular, demandando confirmação diagnóstica por especialista. A concordância interobservador para legibilidade e resultado da leitura (normal, alterado ou inconclusivo) obteve um coeficiente kappa moderado para ambos os olhos (entre 0,4 e 0,6). Em relação à análise intraobservador, o kappa obtido para resultado da leitura foi bom (entre 0,6 e 0,8) e para legibilidade foi moderado. Diferenças de formação e experiência entre leitores poderiam explicar tanto a variação nos coeficientes kappa para o intraobservador, quanto o kappa global. O coeficiente kappa para análise intraobservador de resultado foi bom, sendo que entre os leitores experientes houve maior concordância. Por outro lado, maior número de leitores, incluindo os com maior e menor experiência, permitiu obter coeficiente kappa moderado para análise interobservador de avaliação de anormalidades. Finalmente, os resultados mostraram adequada concordância entre observadores e os achados da retina podem ser usados para avaliar associações com desfechos clínicos incidentes nesta coorte. Os resultados indicam que a avaliação de confiabilidade intraobservador é necessária e que os leitores devem ser experientes ou treinados de forma mais consistente e por mais tempo.

The ELSA-Brasil study aims to investigate risk factors for health…

Advisors/Committee Members: Fuchs, Sandra Cristina Pereira Costa.

Subjects/Keywords: Reprodutibilidade dos testes; Retina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferreira, T. V. (2012). Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/61904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferreira, Thiago Vernetti. “Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil.” 2012. Thesis, Universidade do Rio Grande do Sul. Accessed December 14, 2019. http://hdl.handle.net/10183/61904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferreira, Thiago Vernetti. “Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil.” 2012. Web. 14 Dec 2019.

Vancouver:

Ferreira TV. Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2012. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10183/61904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferreira TV. Reprodutibilidade de leitura de retinografias digitais do ELSA Brasil. [Thesis]. Universidade do Rio Grande do Sul; 2012. Available from: http://hdl.handle.net/10183/61904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

30. Frame, Allan. Digital analysis of the retinal image.

Degree: PhD, 2000, University of Aberdeen

URL: http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602026 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340629

► This thesis considers two distinct but related topics concerned with the analysis of images of the ophthalmic fundus. The first involved the differentiation of automatically… (more)

Subjects/Keywords: 621.3994; Retina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Frame, A. (2000). Digital analysis of the retinal image. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602026 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340629

Chicago Manual of Style (16^th Edition):

Frame, Allan. “Digital analysis of the retinal image.” 2000. Doctoral Dissertation, University of Aberdeen. Accessed December 14, 2019. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602026 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340629.

MLA Handbook (7^th Edition):

Frame, Allan. “Digital analysis of the retinal image.” 2000. Web. 14 Dec 2019.

Vancouver:

Frame A. Digital analysis of the retinal image. [Internet] [Doctoral dissertation]. University of Aberdeen; 2000. [cited 2019 Dec 14]. Available from: http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602026 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340629.

Council of Science Editors:

Frame A. Digital analysis of the retinal image. [Doctoral Dissertation]. University of Aberdeen; 2000. Available from: http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602026 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340629

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Open Access Theses and Dissertations