subject:(Respiratory Tract Diseases)

University of Pretoria

1. Carstens, Ann. Radiological tracheal dimensions of the normal thoroughbred horse .

Degree: 2009, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-02182009-153116/

► Respiratory conditions causing poor performance in horses are usually as result of upper respiratory tract diseases or are of pulmonary origin. The tracheal is rarely… (more)

▼ Respiratory conditions causing poor performance in horses are usually as result of upper respiratory tract diseases or are of pulmonary origin. The tracheal is rarely a cause of primary respiratory problems in the horse, but tracheal dimensions, particularly height, may be useful in evaluating upper repiratory tract conditions cranial to the trachea and lung pathology, due to resultant change in differential pressures between these areas. The normal radiological equine tracheal height along its length has as yet not been reported. Standing lateral radiographs of the cervical and thoracic trachea of 15 clinically normal sedated Thoroughbred horses, 3-6 years old, were made at peak inspiration and end expiration. Maximum height of the larynx, and trachea at the level of the third and fifth cervical vertebra, at the level of the first thoracic vertebra, carina and the left and right primary bronchi were measured. Ratios of laryngeal height relative to the third cervical vertebral body length and tracheal heights relative to the vertebral body lengths of adjacent third and fifth cervical vertebrae and first thoracic vertebra, and carina heights relative to a mid-thoracic vertebra, respectively were made, as well as tracheal height at the fist thoracic vertebra ratio with the thoracic inlet height. Known size metallic markers were used to determine magnification corrected tracheal heights in the sagittal plane and effect of body mass and height at the withers on tracheal height was determined. The magnification corrected radiological airway heights at end expiration and peak inspiration were measured and respectively the mean values were found to be: laryngeal height: 5.89 cm and 5.86 cm, tracheal height at the third cervical vertebra: 4.17 cm and 4.04 cm, tracheal height at the fifth cervical vertebra: 3.62 cm and 3.59 cm, tracheal height at the first thoracic vertebra: 3.4 cm and 3.23 cm and carina height: 3.85 cm and 4.12 cm. The ratios of these measurements to nearby vertebral body lengths were respectively: laryngeal height at the third cervical vertebra: 0.56 and 0.56, tracheal height at the third cervical vertebra: 0.4 and 0.39, tracheal height at the fifth cervical vertebra: 0.37 and 0.37, tracheal height at the first thoracic vertebra: 0.59 and 0.59, and carina height: 0.91 and 0.94. The ratio tracheal height at the first thoracic vertebra to the thoracic inlet respectively 0.15 and 0.15. Although there was no statistical difference in the data, there was a trend towards a higher tracheal height at expiration. No correlation was found between tracheal height and body mass or tracheal height and height at the withers, and measured tracheal height was generally lower than predicted tracheal height, possibly as result of sedation used. The small range of body mass and height in this study as well as the relatively small number of horses evaluated may account for the lack of correlation to predicted tracheal height. This study in normal horses may serve as a reference when radiologically evaluating cases of upper… Advisors/Committee Members: Prof R M Kirberger (advisor).

Subjects/Keywords: Respiratory tract diseases; Horses; UCTD

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APA (6^th Edition):

Carstens, A. (2009). Radiological tracheal dimensions of the normal thoroughbred horse . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-02182009-153116/

Chicago Manual of Style (16^th Edition):

Carstens, Ann. “Radiological tracheal dimensions of the normal thoroughbred horse .” 2009. Masters Thesis, University of Pretoria. Accessed April 12, 2021. http://upetd.up.ac.za/thesis/available/etd-02182009-153116/.

MLA Handbook (7^th Edition):

Carstens, Ann. “Radiological tracheal dimensions of the normal thoroughbred horse .” 2009. Web. 12 Apr 2021.

Vancouver:

Carstens A. Radiological tracheal dimensions of the normal thoroughbred horse . [Internet] [Masters thesis]. University of Pretoria; 2009. [cited 2021 Apr 12]. Available from: http://upetd.up.ac.za/thesis/available/etd-02182009-153116/.

Council of Science Editors:

Carstens A. Radiological tracheal dimensions of the normal thoroughbred horse . [Masters Thesis]. University of Pretoria; 2009. Available from: http://upetd.up.ac.za/thesis/available/etd-02182009-153116/

Edith Cowan University

2. Yano, Yuichi. Bayesian and geostatistical analysis of the effect of air pollution on asthma hospitalisation in Perth.

Degree: 2010, Edith Cowan University

URL: https://ro.ecu.edu.au/theses/1837

► Asthma is a respiratory disease which carries a risk of hospitalisation in severe cases. Numerous studies have shown that air pollution is one of the… (more)

▼ Asthma is a respiratory disease which carries a risk of hospitalisation in severe cases. Numerous studies have shown that air pollution is one of the factors that exacerbates asthma symptoms and while population increases in asthma hospitalisation have been shown for Perth, the nature of exposure and risk across areas within the metropolitan area have not been determined. This study investigates the effect of air pollution concentrations on asthma hospitalisation through building a mathematical model which calculates the risk of asthma hospitalisation for Perth metropolitan areas. The data used in this study are: averaged emission inventory data (NO, CO and PM10) in 2006 and records of asthma hospitalisation for 75 postcodes in the Perth metropolitan region. A time series analysis of the data shows that the seasonality for NO2 and CO coincides with the health data seasonality for all years and all postcode groups. The study makes use of geostatistical and statistical techniques within the hierarchical stages of modelling procedure. The air pollutant concentration in Perth was estimated with the Gaussian Plume Model (GPM) and the lognormal kriging. The risk of asthma hospitalisation was calculated using Bayesian Hierarchical Model (BHM). The outputs from the air pollution model and asthma risk model were incorporated in a Generalised Linear Model (GLM), where the risk of asthma hospitalisation was regressed against the air pollution concentration estimate. The results of GLM analysis showed that the influence of air pollutant on asthma hospitalisation risk varied over time and space. The comparisons of the yearly GLM output suggested that the asthma hospitalisation risk has decreased over the study period, although few acute rises in the risk were observed in some years. This study has demonstrated how environmental data and health data could be integrated in a series of mathematical modelling procedures for predicting possible health hazards at a postcode level.

Subjects/Keywords: respiratory; smog; prediction; forecast; modelling; statistics; health; Respiratory Tract Diseases; Statistics and Probability

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APA (6^th Edition):

Yano, Y. (2010). Bayesian and geostatistical analysis of the effect of air pollution on asthma hospitalisation in Perth. (Thesis). Edith Cowan University. Retrieved from https://ro.ecu.edu.au/theses/1837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yano, Yuichi. “Bayesian and geostatistical analysis of the effect of air pollution on asthma hospitalisation in Perth.” 2010. Thesis, Edith Cowan University. Accessed April 12, 2021. https://ro.ecu.edu.au/theses/1837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yano, Yuichi. “Bayesian and geostatistical analysis of the effect of air pollution on asthma hospitalisation in Perth.” 2010. Web. 12 Apr 2021.

Vancouver:

Yano Y. Bayesian and geostatistical analysis of the effect of air pollution on asthma hospitalisation in Perth. [Internet] [Thesis]. Edith Cowan University; 2010. [cited 2021 Apr 12]. Available from: https://ro.ecu.edu.au/theses/1837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yano Y. Bayesian and geostatistical analysis of the effect of air pollution on asthma hospitalisation in Perth. [Thesis]. Edith Cowan University; 2010. Available from: https://ro.ecu.edu.au/theses/1837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

3. Wang, Kay Yee. Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care.

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:74b15a97-708d-4927-b0aa-ce802f4af2aa ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581065

► Background: Persistent cough following an acute respiratory tract infection is a challenging and frequently encountered problem in primary care. Mycoplasma pneumoniae (M. pneumoniae) and Bordetella… (more)

▼ Background: Persistent cough following an acute respiratory tract infection is a challenging and frequently encountered problem in primary care. Mycoplasma pneumoniae (M. pneumoniae) and Bordetella pertussis (pertussis) particularly predispose patients to persistent cough. Whilst the incidence of M. pneumoniae is highest in children, pertussis may also occur in adults. Method: Four studies were conducted for this thesis. First, a systematic review to assess the diagnostic accuracy of symptoms and signs in the clinical recognition of M. pneumoniae. Second, a retrospective analysis of a cohort of children with persistent cough to assess the prognostic value of diagnosing M. pneumoniae. Third, a prospective cohort study to estimate the prevalence of M. pneumoniae and pertussis in children with persistent cough following recent changes in vaccination policy. Fourth, a double-blind randomised placebo-controlled trial to determine the effectiveness of montelukast in the treatment of persistent cough and pertussis-induced cough in adults. Results: M. pneumoniae and pertussis can each be found in one-sixth of children who present in primary care with persistent cough. Although coverage with the preschool pertussis booster vaccine is high, its efficacy wanes rapidly, with the likelihood of pertussis increasing by 30% per year after vaccination. Montelukast is not an effective treatment for persistent cough, but may be an effective treatment for pertussis-induced cough. Median duration of cough in children with M. pneumoniae is only one-third of that in children with pertussis (39 days versus 118 days). However, the diagnostic accuracy of symptoms and signs in the clinical recognition of M. pneumoniae is limited. Since M. pneumoniae occurs in cyclical epidemics, clinicians should consider current prevalence of M. pneumoniae when making a clinical diagnosis. Conclusions: Diagnosing M. pneumoniae and pertussis can help clinicians give patients an explanation for their cough and inform them about its likely prognosis. At the moment, clinicians should adopt a conservative approach to managing postinfectious persistent cough. A further trial is needed to assess the efficacy of montelukast for the treatment of pertussis-induced cough.

Subjects/Keywords: 616.9; Infectious diseases; Respiratory medicine; Paediatrics; Respiratory Tract Infection; Cough; Whooping cough; Mycoplasma pneumoniae

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APA (6^th Edition):

Wang, K. Y. (2012). Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:74b15a97-708d-4927-b0aa-ce802f4af2aa ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581065

Chicago Manual of Style (16^th Edition):

Wang, Kay Yee. “Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care.” 2012. Doctoral Dissertation, University of Oxford. Accessed April 12, 2021. http://ora.ox.ac.uk/objects/uuid:74b15a97-708d-4927-b0aa-ce802f4af2aa ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581065.

MLA Handbook (7^th Edition):

Wang, Kay Yee. “Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care.” 2012. Web. 12 Apr 2021.

Vancouver:

Wang KY. Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care. [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2021 Apr 12]. Available from: http://ora.ox.ac.uk/objects/uuid:74b15a97-708d-4927-b0aa-ce802f4af2aa ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581065.

Council of Science Editors:

Wang KY. Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care. [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:74b15a97-708d-4927-b0aa-ce802f4af2aa ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581065

Loma Linda University

4. Sauer, Sharon Kay. Sensory Stimulation to Promote Deep Breathing in the Chronic Obstructive Pulmonary Disease Patient.

Degree: MS, Nursing, 1978, Loma Linda University

URL: https://scholarsrepository.llu.edu/etd/764

► Breathing retraining has been an integral part of respiratory rehabilitation for the patient with chronic obstructive pulmonary disease (C.O.P.D.). Techniques used for breathing retraining… (more)

Subjects/Keywords: Nursing; Respiratory Tract Diseases; Respiratory Therapy.

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APA (6^th Edition):

Sauer, S. K. (1978). Sensory Stimulation to Promote Deep Breathing in the Chronic Obstructive Pulmonary Disease Patient. (Thesis). Loma Linda University. Retrieved from https://scholarsrepository.llu.edu/etd/764

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sauer, Sharon Kay. “Sensory Stimulation to Promote Deep Breathing in the Chronic Obstructive Pulmonary Disease Patient.” 1978. Thesis, Loma Linda University. Accessed April 12, 2021. https://scholarsrepository.llu.edu/etd/764.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sauer, Sharon Kay. “Sensory Stimulation to Promote Deep Breathing in the Chronic Obstructive Pulmonary Disease Patient.” 1978. Web. 12 Apr 2021.

Vancouver:

Sauer SK. Sensory Stimulation to Promote Deep Breathing in the Chronic Obstructive Pulmonary Disease Patient. [Internet] [Thesis]. Loma Linda University; 1978. [cited 2021 Apr 12]. Available from: https://scholarsrepository.llu.edu/etd/764.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sauer SK. Sensory Stimulation to Promote Deep Breathing in the Chronic Obstructive Pulmonary Disease Patient. [Thesis]. Loma Linda University; 1978. Available from: https://scholarsrepository.llu.edu/etd/764

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Louisville

5. McAllister, Ryan Carroll. Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age.

Degree: PhD, 2018, University of Louisville

URL: 10.18297/etd/3049 ; https://ir.library.louisville.edu/etd/3049

► Obstructive Airway Diseases (OADs) affect millions of people worldwide, and are characterized by chronic inflammation and tissue remodeling in the lung. It has been… (more)

▼ Obstructive Airway Diseases (OADs) affect millions of people worldwide, and are characterized by chronic inflammation and tissue remodeling in the lung. It has been proposed that the development of OAD is greatly influenced (and perhaps pre-determined) by early life events, such as maternal smoking or a viral infection. However, direct evidence of this is limited and the mechanisms involved remain unclear. Our laboratory previously developed a murine model of perinatal nicotine exposure, and reported that nicotine leads to airway remodeling and decreased pulmonary function in the offspring. We discovered these effects were mediated through the α7 nicotinic acetylcholine receptor (nAChR). Similarly, respiratory viral infections during childhood, such as Influenza A Virus (IAV), have been implicated in the development of OADs in epidemiological and murine studies. We set out to investigate if perinatal nicotine and/or early life IAV infection could promote lung remodeling and long-term pulmonary dysfunction. We employed a previously established murine model for nicotine exposure and a newly developed model for early life IAV infection. Importantly, lung dysfunction was tested at 7-months of age, in which all other studies look at lung dysfunction at earlier times. v We show that both chronic nicotine exposure starting during embryogenesis and continuing until adulthood (but not transient exposure limited to the perinatal period) and early life IAV infection separately are capable of driving lung dysfunction with age. Interestingly, limited differences in lung dysfunction were discovered with chronic exposure and early life IAV infection alone, whereas major lung dysfunctional differences were discovered for transient perinatal nicotine exposure followed by early life IAV infection suggesting a potentiation effect. Abnormalities in lung function were accredited to increased peri-airway collagen deposition and enlarged alveolar structures; the latter appeared due to alveolar simplification during development but also perhaps destruction during aging. We discovered that α7 nAChRs partially mediated these changes. All together, we found that indeed these early life exposures resulted in abnormalities in lung structure and function that persisted into adulthood. This model of nicotine exposure and early life IAV infection in young mice provides a novel tool for studying the impact of these exposures in lung. Advisors/Committee Members: Roman, Jesse, Palmer, Kenneth, Palmer, Kenneth, Lukashevich, Igor, Hoyle, Gary, Chung, Donghoon.

Subjects/Keywords: nicotine; influenza; asthma; COPD; Respiratory Tract Diseases; Translational Medical Research

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McAllister, R. C. (2018). Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/3049 ; https://ir.library.louisville.edu/etd/3049

Chicago Manual of Style (16^th Edition):

McAllister, Ryan Carroll. “Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age.” 2018. Doctoral Dissertation, University of Louisville. Accessed April 12, 2021. 10.18297/etd/3049 ; https://ir.library.louisville.edu/etd/3049.

MLA Handbook (7^th Edition):

McAllister, Ryan Carroll. “Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age.” 2018. Web. 12 Apr 2021.

Vancouver:

McAllister RC. Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age. [Internet] [Doctoral dissertation]. University of Louisville; 2018. [cited 2021 Apr 12]. Available from: 10.18297/etd/3049 ; https://ir.library.louisville.edu/etd/3049.

Council of Science Editors:

McAllister RC. Perinatal nicotine with or without early life influenza infection leads to lung dysfunction with age. [Doctoral Dissertation]. University of Louisville; 2018. Available from: 10.18297/etd/3049 ; https://ir.library.louisville.edu/etd/3049

University of Pretoria

6. Carstens, Ann. Radiological tracheal dimensions of the normal Thoroughbred horse.

Degree: Companion Animal Clinical Studies, 2008, University of Pretoria

URL: http://hdl.handle.net/2263/30220

► Respiratory conditions causing poor performance in horses are usually as result of upper respiratory tract diseases or are of pulmonary origin. The tracheal is rarely… (more)

▼ Respiratory conditions causing poor performance in horses are usually as result of upper respiratory tract diseases or are of pulmonary origin. The tracheal is rarely a cause of primary respiratory problems in the horse, but tracheal dimensions, particularly height, may be useful in evaluating upper repiratory tract conditions cranial to the trachea and lung pathology, due to resultant change in differential pressures between these areas. The normal radiological equine tracheal height along its length has as yet not been reported. Standing lateral radiographs of the cervical and thoracic trachea of 15 clinically normal sedated Thoroughbred horses, 3-6 years old, were made at peak inspiration and end expiration. Maximum height of the larynx, and trachea at the level of the third and fifth cervical vertebra, at the level of the first thoracic vertebra, carina and the left and right primary bronchi were measured. Ratios of laryngeal height relative to the third cervical vertebral body length and tracheal heights relative to the vertebral body lengths of adjacent third and fifth cervical vertebrae and first thoracic vertebra, and carina heights relative to a mid-thoracic vertebra, respectively were made, as well as tracheal height at the fist thoracic vertebra ratio with the thoracic inlet height. Known size metallic markers were used to determine magnification corrected tracheal heights in the sagittal plane and effect of body mass and height at the withers on tracheal height was determined. The magnification corrected radiological airway heights at end expiration and peak inspiration were measured and respectively the mean values were found to be: laryngeal height: 5.89 cm and 5.86 cm, tracheal height at the third cervical vertebra: 4.17 cm and 4.04 cm, tracheal height at the fifth cervical vertebra: 3.62 cm and 3.59 cm, tracheal height at the first thoracic vertebra: 3.4 cm and 3.23 cm and carina height: 3.85 cm and 4.12 cm. The ratios of these measurements to nearby vertebral body lengths were respectively: laryngeal height at the third cervical vertebra: 0.56 and 0.56, tracheal height at the third cervical vertebra: 0.4 and 0.39, tracheal height at the fifth cervical vertebra: 0.37 and 0.37, tracheal height at the first thoracic vertebra: 0.59 and 0.59, and carina height: 0.91 and 0.94. The ratio tracheal height at the first thoracic vertebra to the thoracic inlet respectively 0.15 and 0.15. Although there was no statistical difference in the data, there was a trend towards a higher tracheal height at expiration. No correlation was found between tracheal height and body mass or tracheal height and height at the withers, and measured tracheal height was generally lower than predicted tracheal height, possibly as result of sedation used. The small range of body mass and height in this study as well as the relatively small number of horses evaluated may account for the lack of correlation to predicted tracheal height. This study in normal horses may serve as a reference when radiologically evaluating cases of upper… Advisors/Committee Members: Kirberger, Robert M. (advisor).

Subjects/Keywords: Respiratory tract diseases; Horses; UCTD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carstens, A. (2008). Radiological tracheal dimensions of the normal Thoroughbred horse. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/30220

Chicago Manual of Style (16^th Edition):

Carstens, Ann. “Radiological tracheal dimensions of the normal Thoroughbred horse.” 2008. Masters Thesis, University of Pretoria. Accessed April 12, 2021. http://hdl.handle.net/2263/30220.

MLA Handbook (7^th Edition):

Carstens, Ann. “Radiological tracheal dimensions of the normal Thoroughbred horse.” 2008. Web. 12 Apr 2021.

Vancouver:

Carstens A. Radiological tracheal dimensions of the normal Thoroughbred horse. [Internet] [Masters thesis]. University of Pretoria; 2008. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/2263/30220.

Council of Science Editors:

Carstens A. Radiological tracheal dimensions of the normal Thoroughbred horse. [Masters Thesis]. University of Pretoria; 2008. Available from: http://hdl.handle.net/2263/30220

Universidade Nova

7. Piedade, Cátia Marina Rodrigues da. Etiologia das infeções respiratórias virais em criançass em idade pré-escolar.

Degree: 2013, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9999

► RESUMO: Os vírus respiratórios continuam a ocupar um papel relevante na morbilidade e mortalidade infantil, tendo na última década sido alargado o espectro de vírus… (more)

▼ RESUMO: Os vírus respiratórios continuam a ocupar um papel relevante na morbilidade e mortalidade infantil, tendo na última década sido alargado o espectro de vírus potencialmente causadores das infeções respiratórias. O diagnóstico destas infeções pode ser efetuado por várias metodologias, sendo as técnicas de biologia molecular consideradas as mais sensíveis para este fim. No âmbito do Projeto Ambiente e Saúde em Creches e Infantários (ENVIRH) foi efetuada uma comparação da prevalência dos principais vírus respiratórios em crianças em idade pré-escolar, com critérios de infeção respiratória, recorrendo a técnicas de biologia molecular, em duas populações: crianças que se encontravam na escola/domicilio e crianças que recorreram a uma urgência hospitalar. O estudo decorreu em dois períodos, de Fevereiro a Maio de 2011 e de Outubro de 2011 a Abril de 2012. Foram efetuadas duas colheitas de zaragatoas, uma nasal e outra orofaríngea. A metodologia utilizada para a identificação viral nas amostras foi a PCR e RT-PCR multiplex em tempo real. Os vírus pesquisados foram: Influenza A e B, Parainfluenza 1-4, Metapneumovirus humano, Vírus Sincicial respiratório (VSR), Rinovírus, Enterovírus, Coronavírus e Bocavirus. Foram realizadas 100 colheitas em crianças com idades compreendidas entre os 5 meses e os 5 anos. Foram obtidas 64 amostras dos infantários/domicílios, das quais 47 foram positivas. Da urgência Hospitalar obtiveram-se 36 amostras, em que 32 foram positivas. O vírus da gripe A (H3) foi o mais frequentemente detetado nas duas populações, mas apenas durante o surto de 2012. O VSR e os adenovírus foram mais frequentes nas crianças que recorreram ao hospital, ao contrário dos enterovirus e dos coronavírus, que não foram detetados nesta população. Os bocavirus nunca foram detetados isoladamente. Este estudo reforça a importância de se utilizarem técnicas de biologia molecular para o diagnóstico etiológico das infeções respiratórias, devido à elevada sensibilidade das mesmas, o que se reflete na elevada percentagem de amostras positivas. O facto de se utilizarem técnicas “multiplex”, que permitem a pesquisa simultânea de vários vírus, facilita a deteção de um maior espectro destes agentes. A elevada prevalência de Influenza A H3N2 deveu-se ao facto de grande parte do estudo ter coincidido com um período de surto por este vírus. O sistema de alerta montado durante o projeto ENVIRH pareceu promissor para uma eventual utilização futura em períodos de atividade gripal. – – – – – ABSTRACT: In the last decade, as respiratory viruses keep representing a relevant factor in child morbidity and mortality, the spectrum of viruses that may potentially cause respiratory infections has been widened. Within the several methodologies that may be applied in the diagnosis of these types of infections, the ones that use molecular biology are considered to be the most sensitive. The Environment and Health in Daycares and Nurseries Project (ENVIRH) arranged for a study, by means of molecular biology techniques, on the main respiratory…

Subjects/Keywords: Respiratory Tract Infections; Child virus diseases; Infant Mortality; Influenza

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APA (6^th Edition):

Piedade, C. M. R. d. (2013). Etiologia das infeções respiratórias virais em criançass em idade pré-escolar. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9999

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Piedade, Cátia Marina Rodrigues da. “Etiologia das infeções respiratórias virais em criançass em idade pré-escolar.” 2013. Thesis, Universidade Nova. Accessed April 12, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9999.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Piedade, Cátia Marina Rodrigues da. “Etiologia das infeções respiratórias virais em criançass em idade pré-escolar.” 2013. Web. 12 Apr 2021.

Vancouver:

Piedade CMRd. Etiologia das infeções respiratórias virais em criançass em idade pré-escolar. [Internet] [Thesis]. Universidade Nova; 2013. [cited 2021 Apr 12]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9999.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Piedade CMRd. Etiologia das infeções respiratórias virais em criançass em idade pré-escolar. [Thesis]. Universidade Nova; 2013. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9999

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

8. Enright, Mark Charles. Molecular characterization of Moraxella catarrhalis.

Degree: Dept. of Medical Microbiology, 1994, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158242 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158242&custom_att_2=simple_viewer

Subjects/Keywords: Moraxella.; Respiratory tract diseases

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APA (6^th Edition):

Enright, M. C. (1994). Molecular characterization of Moraxella catarrhalis. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158242 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158242&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Enright, Mark Charles. “Molecular characterization of Moraxella catarrhalis.” 1994. Doctoral Dissertation, University of Aberdeen. Accessed April 12, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158242 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158242&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Enright, Mark Charles. “Molecular characterization of Moraxella catarrhalis.” 1994. Web. 12 Apr 2021.

Vancouver:

Enright MC. Molecular characterization of Moraxella catarrhalis. [Internet] [Doctoral dissertation]. University of Aberdeen; 1994. [cited 2021 Apr 12]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158242 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158242&custom_att_2=simple_viewer.

Council of Science Editors:

Enright MC. Molecular characterization of Moraxella catarrhalis. [Doctoral Dissertation]. University of Aberdeen; 1994. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158242 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158242&custom_att_2=simple_viewer

University of Aberdeen

9. Enright, Mark Charles. Molecular characterization of Moraxella catarrhalis.

Degree: PhD, 1994, University of Aberdeen

URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152970590005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259666

► <I>Moraxella catarrhalis</I> is a gram-negative diplococcus which until recently was thought to be a harmless commensal. Increasing awareness has established the pathogenic nature of this… (more)

Subjects/Keywords: 579; Moraxella; Respiratory tract diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Enright, M. C. (1994). Molecular characterization of Moraxella catarrhalis. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152970590005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259666

Chicago Manual of Style (16^th Edition):

Enright, Mark Charles. “Molecular characterization of Moraxella catarrhalis.” 1994. Doctoral Dissertation, University of Aberdeen. Accessed April 12, 2021. https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152970590005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259666.

MLA Handbook (7^th Edition):

Enright, Mark Charles. “Molecular characterization of Moraxella catarrhalis.” 1994. Web. 12 Apr 2021.

Vancouver:

Enright MC. Molecular characterization of Moraxella catarrhalis. [Internet] [Doctoral dissertation]. University of Aberdeen; 1994. [cited 2021 Apr 12]. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152970590005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259666.

Council of Science Editors:

Enright MC. Molecular characterization of Moraxella catarrhalis. [Doctoral Dissertation]. University of Aberdeen; 1994. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152970590005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259666

Universidade Estadual de Campinas

10. Vian, Bruna Scharlack, 1979-. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Clínica Médica, 2012, Universidade Estadual de Campinas

URL: VIAN, Bruna Scharlack. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. 2012. 83 f. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/311764>. Acesso em: 19 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/311764

►

Orientador: Ricardo de Lima Zollner

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-08-19T21:14:23Z (GMT). No. of… (more)

▼

Orientador: Ricardo de Lima Zollner

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-08-19T21:14:23Z (GMT). No. of bitstreams: 1 Vian_BrunaScharlack_M.pdf: 1879886 bytes, checksum: d9b52c103c4a6cca51810138e9c47e14 (MD5) Previous issue date: 2012

Resumo: A rinite alérgica (RA) é definida como uma inflamação da mucosa nasal, resultando em sintomas nasais que incluem rinorréia, obstrução, prurido e espirros. O fator de crescimento neural (NGF) está envolvido na fisiopatologia de inflamação alérgica. Soluções salinas nasais em diversas concentrações têm sido usadas para prevenir ou reduzir sintomas alérgicos, porém as concentrações ideais das soluções de cloreto de sódio nasal ainda não estão bem estabelecidas na literatura disponível. O objetivo desse estudo foi avaliar o efeito das soluções salinas: isotônica (ISO), hipertônica 3% (HIPER) e agua destilada (HIPO) em pacientes com RA persistente, comparando os escores clínicos dos sintomas nasais, avaliação do escore olfativo e a expressão gênica de NGF como marcador inflamatório do conteúdo celular nasal e considerando temperatura e umidade nos diferentes períodos em que utizaram as soluções. Trinta (30) pacientes com diagnóstico de RA persistente iniciaram o estudo, porem apenas 13 terminaram. Os pacientes foram divididos em 3 grupos aleatorizados que utilizaram as 3 soluções: ISO, HIPER e HIPO em 3 períodos diferentes (P1, P2 e P3). Os critérios clínicos de avaliação dos sintomas eram avaliados por meio de "Questionário Validado", onde somava-se o total do escore dos sintomas nasais (TESN). Para a avaliação do sintoma olfato era aplicado um escore olfativo de 0 a 8 com diluições de essência de eucalipto. Foi realizada coleta de material da mucosa nasal para o estudo da expressão gênica de NGF por meio de Reação de Polimerase em Cadeia (PCR). Os resultados observados neste estudo foram que no P1, os pacientes apresentaram melhora do TESN (p=0.004), quando comparada com a HIPER. Tanto o grupo que iniciou o tratamento com a solução ISO (p= 0,056), quanto o grupo que iniciou com HIPO (p= 0,063) tiveram uma tendência de melhora quando comparada com a HIPER. Todos os grupos no P1 apresentaram melhora do escore olfativo. O grupo que iniciou com a solução HIPER mostrou valores de expressão de NGF significativamente maiores (p=0,023). Conclui-se então, que as soluções salinas podem ser utilizadas como tratamento adjuvante na RA, pois melhorou os sintomas e melhorou o escore olfativo, porém a solução HIPER aumentou expressão de NGF na mucosa nasal

Allergic rhinitis (AR) is defined as inflammation of the nasal mucosa, resulting in nasal symptoms including rhinorrhea, obstruction, itching and sneezing. Neural growth factor (NGF) is involved in the pathophysiology of allergic inflammation. Nasal saline solutions, at various concentrations, have been used to prevent or reduce allergic symptoms, but the ideal concentration of nasal sodium chloride solutions are not well established in the…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Zollner, Ricardo de Lima, 1954-, Gusmão, Reinaldo Jordão, Junior, Persio Roxo.

Subjects/Keywords: Prevenção; Farmacologia; Doenças respiratórias; Prevention; Phamacology; Respiratory tract diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vian, Bruna Scharlack, 1. (2012). Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from VIAN, Bruna Scharlack. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. 2012. 83 f. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/311764>. Acesso em: 19 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/311764

Chicago Manual of Style (16^th Edition):

Vian, Bruna Scharlack, 1979-. “Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente.” 2012. Masters Thesis, Universidade Estadual de Campinas. Accessed April 12, 2021. VIAN, Bruna Scharlack. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. 2012. 83 f. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/311764>. Acesso em: 19 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/311764.

MLA Handbook (7^th Edition):

Vian, Bruna Scharlack, 1979-. “Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente.” 2012. Web. 12 Apr 2021.

Vancouver:

Vian, Bruna Scharlack 1. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Apr 12]. Available from: VIAN, Bruna Scharlack. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. 2012. 83 f. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/311764>. Acesso em: 19 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/311764.

Council of Science Editors:

Vian, Bruna Scharlack 1. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. [Masters Thesis]. Universidade Estadual de Campinas; 2012. Available from: VIAN, Bruna Scharlack. Efeito da aplicação nasal de diferentes soluçõeo salinas sobre os sintomas, sensibilidade olfativa e expressão de fator crescimento neural (NGF) em pacientes com rinopatia alégica persistente. 2012. 83 f. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/311764>. Acesso em: 19 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/311764

11. Lovrinic, Alexandra. Characterization of isolates and whole samples from turkeys infected with bordetellosis.

Degree: 2018, James Madison University

URL: https://commons.lib.jmu.edu/honors201019/514

► Bordetellosis is a disease in turkeys attributed to the Gram-negative bacterium, Bordetella avium. The closely related species, B. hinzii, is known to colonize in turkeys… (more)

Subjects/Keywords: bordetella hinzii; bordetella avium; bordetellosis; turkeys; Animal Diseases; Bacterial Infections and Mycoses; Respiratory Tract Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lovrinic, A. (2018). Characterization of isolates and whole samples from turkeys infected with bordetellosis. (Masters Thesis). James Madison University. Retrieved from https://commons.lib.jmu.edu/honors201019/514

Chicago Manual of Style (16^th Edition):

Lovrinic, Alexandra. “Characterization of isolates and whole samples from turkeys infected with bordetellosis.” 2018. Masters Thesis, James Madison University. Accessed April 12, 2021. https://commons.lib.jmu.edu/honors201019/514.

MLA Handbook (7^th Edition):

Lovrinic, Alexandra. “Characterization of isolates and whole samples from turkeys infected with bordetellosis.” 2018. Web. 12 Apr 2021.

Vancouver:

Lovrinic A. Characterization of isolates and whole samples from turkeys infected with bordetellosis. [Internet] [Masters thesis]. James Madison University; 2018. [cited 2021 Apr 12]. Available from: https://commons.lib.jmu.edu/honors201019/514.

Council of Science Editors:

Lovrinic A. Characterization of isolates and whole samples from turkeys infected with bordetellosis. [Masters Thesis]. James Madison University; 2018. Available from: https://commons.lib.jmu.edu/honors201019/514

12. Tacao, Guilherme Yassuyuki [UNESP]. Impacto da exposição à queima de biomassa sobre a taxa de prevalência em doenças respiratórias e cardiovasculares na região de Presidente Prudente.

Degree: 2017, Universidade Estadual Paulista (UNESP)

URL: http://hdl.handle.net/11449/152166

►

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Rejected by Luiz Galeffi ([email protected]), reason:… (more)

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Advisors/Committee Members: Universidade Estadual Paulista (UNESP), Ramos, Dionei [UNESP].

Subjects/Keywords: Poluição do ar; Doenças respiratórias; Doenças cardiovasculares; Air pollution; Respiratory tract diseases; Cardiovascular diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tacao, G. Y. [. (2017). Impacto da exposição à queima de biomassa sobre a taxa de prevalência em doenças respiratórias e cardiovasculares na região de Presidente Prudente. (Masters Thesis). Universidade Estadual Paulista (UNESP). Retrieved from http://hdl.handle.net/11449/152166

Chicago Manual of Style (16^th Edition):

Tacao, Guilherme Yassuyuki [UNESP]. “Impacto da exposição à queima de biomassa sobre a taxa de prevalência em doenças respiratórias e cardiovasculares na região de Presidente Prudente.” 2017. Masters Thesis, Universidade Estadual Paulista (UNESP). Accessed April 12, 2021. http://hdl.handle.net/11449/152166.

MLA Handbook (7^th Edition):

Tacao, Guilherme Yassuyuki [UNESP]. “Impacto da exposição à queima de biomassa sobre a taxa de prevalência em doenças respiratórias e cardiovasculares na região de Presidente Prudente.” 2017. Web. 12 Apr 2021.

Vancouver:

Tacao GY[. Impacto da exposição à queima de biomassa sobre a taxa de prevalência em doenças respiratórias e cardiovasculares na região de Presidente Prudente. [Internet] [Masters thesis]. Universidade Estadual Paulista (UNESP); 2017. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/11449/152166.

Council of Science Editors:

Tacao GY[. Impacto da exposição à queima de biomassa sobre a taxa de prevalência em doenças respiratórias e cardiovasculares na região de Presidente Prudente. [Masters Thesis]. Universidade Estadual Paulista (UNESP); 2017. Available from: http://hdl.handle.net/11449/152166

13. Repasy, Teresa S. Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation.

Degree: Interdisciplinary Graduate Program, Medicine, 2014, U of Massachusetts : Med

URL: http://escholarship.umassmed.edu/gsbs_diss/747

► Mycobacterium tuberculosis, the causative agent of tuberculosis, can manipulate host cell death pathways as virulent strains inhibit apoptosis to protect its replication niche and… (more)

▼ Mycobacterium tuberculosis, the causative agent of tuberculosis, can manipulate host cell death pathways as virulent strains inhibit apoptosis to protect its replication niche and induce necrosis as a mechanism of escape. In vitro studies revealed that similar to lytic viruses, M. tuberculosis has the ability to induce cytolysis in macrophages when it reaches an intracellular burden of ~25 bacilli. Base on this finding, we proposed the burst size hypothesis that states when M. tuberculosis invades a macrophage at a low multiplicity of infection it replicates to a burst size triggering necrosis to escape the cell and infect naïve nearby phagocytes, propagating the spread of infection. The first part of this study investigated if the in vitro observations of M. tuberculosis cytolysis were relevant to cell death of infected phagocytes during pulmonary tuberculosis in vivo. Mice infected with a low dose of M. tuberculosis revealed during TB disease, the major host cell shifted from one type of phagocyte to another. Enumeration of intracellular bacilli from infected lung cells revealed the predictions of the hypothesis were confirmed by the distribution of bacillary loads across the population of infected phagocytes. Heavily burdened cells appeared nonviable sharing distinctive features similar to infected macrophages from in vitro studies. Collectively, the data indicates that M. tuberculosis triggers necrosis in mononuclear cells when its number reaches the threshold burst size. The previous study showed during the period of logarithmic bacterial expansion, neutrophils were the primary host cell for M. tuberculosis coinciding with the timeframe of the highest rate of burst size necrosis. The second part of this study examined this link by infecting mice with one of four different M. tuberculosis strains ranging in virulence. Mice infected with the most virulent strain had the highest bacterial burden and elicited the greatest number of infected neutrophils with the most extensive lung inflammation and greater accounts of cell death. Treating these mice with a bacteriostatic agent decreased the bacterial load and infected neutrophils in a dose-dependent manner indicating necrosis induced by virulent M. tuberculosis recruited neutrophils to the lungs. Infected neutrophils can serve as a biomarker in tuberculosis as evidenced by poorly controlled infection and increased severity of lung immune pathology. Advisors/Committee Members: Hardy Kornfeld, MD.

Subjects/Keywords: Mycobacterium tuberculosis; Macrophages; Necrosis; Pulmonary Tuberculosis; Virulence; Bacterial Load; Bacteriology; Immunopathology; Respiratory Tract Diseases; Virology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Repasy, T. S. (2014). Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from http://escholarship.umassmed.edu/gsbs_diss/747

Chicago Manual of Style (16^th Edition):

Repasy, Teresa S. “Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation.” 2014. Doctoral Dissertation, U of Massachusetts : Med. Accessed April 12, 2021. http://escholarship.umassmed.edu/gsbs_diss/747.

MLA Handbook (7^th Edition):

Repasy, Teresa S. “Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation.” 2014. Web. 12 Apr 2021.

Vancouver:

Repasy TS. Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2014. [cited 2021 Apr 12]. Available from: http://escholarship.umassmed.edu/gsbs_diss/747.

Council of Science Editors:

Repasy TS. Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2014. Available from: http://escholarship.umassmed.edu/gsbs_diss/747

University of Western Ontario

14. Svenningsen, Sarah. Pulmonary Imaging to Better Understand Asthma.

Degree: 2015, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/3352

► Asthma is characterized using the spirometry measurement of the forced expiratory volume in one second (FEV1). Simple and inexpensive, FEV1 provides a global estimate of… (more)

▼ Asthma is characterized using the spirometry measurement of the forced expiratory volume in one second (FEV1). Simple and inexpensive, FEV1 provides a global estimate of lung function but this metric cannot regionally identify airways responsible for airflow limitation, asthma symptoms or control. Work that brought about an understanding that airway abnormalities are heterogeneously distributed within the lung in asthma patients has motivated the development of pulmonary imaging approaches, such as hyperpolarized helium-3 (3He) and xenon-129 (129Xe) magnetic resonance imaging (MRI). These methods provide a way to visualize and quantify lung regions accessed by gas during a breath-hold, as well as those not accessed, referred to as “ventilation defects.” Despite the strong foundation for the use of MRI in asthma clinical care, clinical translation has been inhibited in part due to the current limited clinical and physiological understanding of ventilation defects. Accordingly, our objective was to better understand the structural determinants and clinical consequences of MRI ventilation defects observed in asthma and to provide a foundation for imaging to guide clinical decisions and asthma therapy. We evaluated the effect of gas properties on ventilation defects. In asthmatics, we compared hyperpolarized 3He and 129Xe MRI before and after bronchodilator administration and showed greater gas distribution abnormalities using 129Xe compared to 3He before bronchodilation. The temporal behavior of asthma ventilation defects was then investigated by generating personalized temporal-spatial pulmonary function maps from 3He MR images acquired on three occasions. Persistent and intermittent defects were visualized and quantified using this tool and were recognized as potential intermediate endpoints or targets for treatment. We then evaluated clinical and emerging computed tomography-derived airway morphology measurements in asthmatics with and without defects. Ventilation defects were observed in two-thirds of well-controlled asthmatics who had worse lung function, increased airway inflammation, airway hyperresponsiveness and greater airway wall thickness than asthmatics without ventilation defects. Acknowledging that asthma control is the primary goal of asthma treatment, we investigated the relationship, and established a link between worse ventilation and poor control. These findings provide a better understanding of asthma ventilation defects and strongly support their potential as a novel treatment target.

Subjects/Keywords: Asthma; Lung Function; Magnetic Resonance Imaging; Hyperpolarized 3He; Hyperpolarized 129Xe; Ventilation Defect; Medical Biophysics; Respiratory System; Respiratory Tract Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Svenningsen, S. (2015). Pulmonary Imaging to Better Understand Asthma. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Svenningsen, Sarah. “Pulmonary Imaging to Better Understand Asthma.” 2015. Thesis, University of Western Ontario. Accessed April 12, 2021. https://ir.lib.uwo.ca/etd/3352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Svenningsen, Sarah. “Pulmonary Imaging to Better Understand Asthma.” 2015. Web. 12 Apr 2021.

Vancouver:

Svenningsen S. Pulmonary Imaging to Better Understand Asthma. [Internet] [Thesis]. University of Western Ontario; 2015. [cited 2021 Apr 12]. Available from: https://ir.lib.uwo.ca/etd/3352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Svenningsen S. Pulmonary Imaging to Better Understand Asthma. [Thesis]. University of Western Ontario; 2015. Available from: https://ir.lib.uwo.ca/etd/3352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

15. Paudyal, Priyamvada. Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal.

Degree: Dept. of Environmental and Occupational Medicine., 2011, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=166944 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=166944&custom_att_2=simple_viewer

Subjects/Keywords: Textile workers; Respiratory organs; Respiratory Tract Diseases.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paudyal, P. (2011). Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=166944 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=166944&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Paudyal, Priyamvada. “Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed April 12, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=166944 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=166944&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Paudyal, Priyamvada. “Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal.” 2011. Web. 12 Apr 2021.

Vancouver:

Paudyal P. Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2021 Apr 12]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=166944 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=166944&custom_att_2=simple_viewer.

Council of Science Editors:

Paudyal P. Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=166944 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=166944&custom_att_2=simple_viewer

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

16. Τσοτουλίδου, Βασιλική. Ο ρόλος των διαφόρων τύπων των κοροναϊών και του ιού του αναπνευστικού συγκυτίου, στις λοιμώξεις του αναπνευστικού συστήματος παιδιών με νεοπλασματικά νοσήματα.

Degree: 2012, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/27609

►

Cancer in childhood is uncommon, representing about 1% of all cancer cases. Patients with cancer are immunosuppressed due to humoral and cell mediated immunity disorder.… (more)

▼

Cancer in childhood is uncommon, representing about 1% of all cancer cases. Patients with cancer are immunosuppressed due to humoral and cell mediated immunity disorder. Thus, increased susceptibility to bacterial, fungal and viral infections is observed. Respiratory tract infections are common in children with malignancies. The causative agents and clinical symptoms vary. In patients with cancer, these infections can be severe or have a fatal outcome, due to the co-existing immunosuppression. Coronaviruses and respiratory syncytial virus are included among respiratory pathogens that affect these children. The purpose of this study was to evaluate the role of coronaviruses and respiratory syncytial virus in respiratory tract infections in immunocompromised children with cancer. One hundred and fifty eight respiratory tract infection of 97 children with malignancies while receiving chemotherapy (haematological malignancies and solid tumors) and 161 respiratory tract infections of 161 immunocompetent children were studied during January 2007 – May 2009. A pharyngeal swab sample was obtained and polymerase chain reaction was used for virus detection. Statistical analysis of our results was done with statistical program SPSS. Coronavirus infections are rare in children with cancer (126%). Their prevalence is equal among immunocompromised and immunocompetent children. HCoV-NL63 was the only coronavirus detected in our study. Most infections were mild upper respiratory tract infections with favourable outcome. No death was recorded. Coinfections between HCoV-NL63 and adenovirus were detected. RSV infections are common among children with cancer (8.86%). Their prevalence is almost equal among immunocompromised and immunocompetent children. Both RSVA and RSVB subtypes cause respiratory tract infections in children with cancer. There was no significant difference between the prevalence of RSVA and RSVB subtypes in children with cancer or immunocompromised and immunocompetent children. RSV positivity was strongly associated with ages ≤2 years old. Most infections were mild upper respiratory tract infections with favourable outcome. No death was recorded. The peak prevalence of RSV disease occurred during spring time, in March. Mean disease duration and mean hospital stay did not differ between immunocompromised and ιmmunocompetent children. Most RSV infections were detected in lymphopenic children. There was no indication that one serotype caused more severe infection than the other. No association was found between RSV prevalence or severity with smoking, place of residence, presence of school age children, prematurity, breastfeeding and obesity. Dual infections between the RSV and other viruses or between the RSVA and RSVB were not detected in children with cancer. In conclusion, coronaviruses and respiratory syncytial virus are included among respiratory pathogens that affect children with cancer. Most infections were mild upper respiratory tract infections with favourable outcome.

Τα νεοπλασματικά νοσήματα στην παιδική…

Subjects/Keywords: Κοροναϊοί; Ιός αναπνευστικού συγκυτίου; Λοιμώξεις αναπνευστικού συστήματος; Νεοπλασματικά νοσήματα; Παιδιά; Coronaviruses; Respiratory syncytial virus; Respiratory tract infections; Malignant diseases; Children

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Τσοτουλίδου, . �. (2012). Ο ρόλος των διαφόρων τύπων των κοροναϊών και του ιού του αναπνευστικού συγκυτίου, στις λοιμώξεις του αναπνευστικού συστήματος παιδιών με νεοπλασματικά νοσήματα. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/27609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Τσοτουλίδου, Βασιλική. “Ο ρόλος των διαφόρων τύπων των κοροναϊών και του ιού του αναπνευστικού συγκυτίου, στις λοιμώξεις του αναπνευστικού συστήματος παιδιών με νεοπλασματικά νοσήματα.” 2012. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed April 12, 2021. http://hdl.handle.net/10442/hedi/27609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Τσοτουλίδου, Βασιλική. “Ο ρόλος των διαφόρων τύπων των κοροναϊών και του ιού του αναπνευστικού συγκυτίου, στις λοιμώξεις του αναπνευστικού συστήματος παιδιών με νεοπλασματικά νοσήματα.” 2012. Web. 12 Apr 2021.

Vancouver:

Τσοτουλίδου �. Ο ρόλος των διαφόρων τύπων των κοροναϊών και του ιού του αναπνευστικού συγκυτίου, στις λοιμώξεις του αναπνευστικού συστήματος παιδιών με νεοπλασματικά νοσήματα. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2012. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10442/hedi/27609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Τσοτουλίδου �. Ο ρόλος των διαφόρων τύπων των κοροναϊών και του ιού του αναπνευστικού συγκυτίου, στις λοιμώξεις του αναπνευστικού συστήματος παιδιών με νεοπλασματικά νοσήματα. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2012. Available from: http://hdl.handle.net/10442/hedi/27609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

17. Paudyal, Priyamvada. Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal.

Degree: PhD, 2011, University of Aberdeen

URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153044260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542652

► Background: Cotton workers are highly exposed to organic dust. Inhalation of cotton based particulate has been associated with various respiratory symptoms and impaired lung function.… (more)

Subjects/Keywords: 616.2; Textile workers; Respiratory organs; Respiratory Tract Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paudyal, P. (2011). Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153044260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542652

Chicago Manual of Style (16^th Edition):

Paudyal, Priyamvada. “Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed April 12, 2021. https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153044260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542652.

MLA Handbook (7^th Edition):

Paudyal, Priyamvada. “Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal.” 2011. Web. 12 Apr 2021.

Vancouver:

Paudyal P. Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2021 Apr 12]. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153044260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542652.

Council of Science Editors:

Paudyal P. Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153044260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542652

Virginia Commonwealth University

18. Bradley, Jennifer L. Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation.

Degree: MS, Molecular Biology and Genetics, 2016, Virginia Commonwealth University

URL: https://doi.org/10.25772/EBNV-H932 ; https://scholarscompass.vcu.edu/etd/4576

► Obesity is recognized as an important risk factor for the development of many chronic diseases such as hypertension, Type 2 diabetes mellitus (T2DM) cardiovascular… (more)

Subjects/Keywords: obesity; asthma; IL-13; Adiponectin; normal human bronchial epithelial (NHBE) cells; Immune System Diseases; Respiratory Tract Diseases

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APA (6^th Edition):

Bradley, J. L. (2016). Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/EBNV-H932 ; https://scholarscompass.vcu.edu/etd/4576

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bradley, Jennifer L. “Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation.” 2016. Thesis, Virginia Commonwealth University. Accessed April 12, 2021. https://doi.org/10.25772/EBNV-H932 ; https://scholarscompass.vcu.edu/etd/4576.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bradley, Jennifer L. “Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation.” 2016. Web. 12 Apr 2021.

Vancouver:

Bradley JL. Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation. [Internet] [Thesis]. Virginia Commonwealth University; 2016. [cited 2021 Apr 12]. Available from: https://doi.org/10.25772/EBNV-H932 ; https://scholarscompass.vcu.edu/etd/4576.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bradley JL. Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation. [Thesis]. Virginia Commonwealth University; 2016. Available from: https://doi.org/10.25772/EBNV-H932 ; https://scholarscompass.vcu.edu/etd/4576

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Commonwealth University

19. Mohammed, Bassem M. Vitamin C: A potential regulator of inflammatory response.

Degree: PhD, Pharmacotherapy and Outcomes Science, 2015, Virginia Commonwealth University

URL: https://doi.org/10.25772/0KBV-0H96 ; https://scholarscompass.vcu.edu/etd/3699

► Introduction: Neutrophils (PMNs) and Macrophages are the first responders recruited consecutively to the site of injury/inflammation. PMNs’ response/fate as well as macrophage reprogramming ultimately… (more)

▼ Introduction: Neutrophils (PMNs) and Macrophages are the first responders recruited consecutively to the site of injury/inflammation. PMNs’ response/fate as well as macrophage reprogramming ultimately determine the course of resolution of inflammation. Physiologic wound healing has a significant inflammatory component. An exaggerated inflammation however is self-defeating leading to delayed healing. Parenteral vitamin C (VitC) attenuated inflammation in murine sepsis models and in patients with sepsis. However information about the mechanisms by which VitC regulates these events is limited. Methods: Humanized mice lacking VitC synthesis capability (Gulo^-/-) were used. VitC sufficient and deficient mice were challenged with sterile inflammation, or septic insults. Some VitC deficient mice received parenteral VitC (200mg/kg) following the challenge to give deficient + AscA mice up to 14 days. Using a murine model of excisional wound, two full thickness excisional wounds were created on the back of the different Gulo^-/- mice groups. Wound tissues were excised at day 7 and 14 post-wounding for analysis. Cell counts, immunohistochemistry, circulating free DNA, the expression of pro- and anti-inflammatory proteins were investigated. Additional in vitro experiments were carried out using human PMN (huPMNs), THP-1 monocyte/macrophage, and neonatal human dermal fibroblasts (HnDF). Results: VitC deficiency delayed resolution of lung inflammation and led to exaggerated pro-inflammatory responses. PMNs from VitC deficient mice demonstrated increased autophagy, histone citrullination, and NFκB activation, while inhibiting apoptosis. VitC sufficiency/supplementation restored macrophage phenotype, as well as attenuated neutrophil extracellular trap (NET) formation. VitC attenuated pro-inflammatory responses in THP-1 macrophages. In wound healing model, wounds from VitC sufficient/AscA infused mice had lower gene expression of the pro-inflammatory mediators; higher expression of genes promoting wound healing and resolution. Exposure of HnDF to AscA increased their intracellular VitC levels; promoted fibroblast proliferation and induced expression of fibroblast self-renewal genes. Conclusion: Our findings identify VitC as a novel regulator of PMN and macrophage responses. In wound healing, VitC favorably impacted the spatiotemporal expression of transcripts associated with early resolution of inflammation and tissue remodeling. Collectively, these results substantiate the protective notion of parenteral VitC and support its clinical use. Advisors/Committee Members: Donald F. Brophy, Gretchen M. Brophy, Ramesh Natarajan, Bruce Spiess, Jurgen Venitz.

Subjects/Keywords: Vitamin C; Inflammation; Resolution; Neutrophils; Macrophages; Wound healing; Cardiology; Cardiovascular Diseases; Critical Care; Other Pharmacy and Pharmaceutical Sciences; Respiratory Tract Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mohammed, B. M. (2015). Vitamin C: A potential regulator of inflammatory response. (Doctoral Dissertation). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/0KBV-0H96 ; https://scholarscompass.vcu.edu/etd/3699

Chicago Manual of Style (16^th Edition):

Mohammed, Bassem M. “Vitamin C: A potential regulator of inflammatory response.” 2015. Doctoral Dissertation, Virginia Commonwealth University. Accessed April 12, 2021. https://doi.org/10.25772/0KBV-0H96 ; https://scholarscompass.vcu.edu/etd/3699.

MLA Handbook (7^th Edition):

Mohammed, Bassem M. “Vitamin C: A potential regulator of inflammatory response.” 2015. Web. 12 Apr 2021.

Vancouver:

Mohammed BM. Vitamin C: A potential regulator of inflammatory response. [Internet] [Doctoral dissertation]. Virginia Commonwealth University; 2015. [cited 2021 Apr 12]. Available from: https://doi.org/10.25772/0KBV-0H96 ; https://scholarscompass.vcu.edu/etd/3699.

Council of Science Editors:

Mohammed BM. Vitamin C: A potential regulator of inflammatory response. [Doctoral Dissertation]. Virginia Commonwealth University; 2015. Available from: https://doi.org/10.25772/0KBV-0H96 ; https://scholarscompass.vcu.edu/etd/3699

20. Patiwael, Jiska. Interplay Between Allergy and Work.

Degree: 2012, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/77064

► markdownabstract__Abstract__ Rhinitis is acknowledged to have both a health and a socio-economic impact. Furthermore, the link between upper and lower respiratory tract - concerning rhinitis… (more)

Subjects/Keywords: rhinitis; respiratory tract diseases; asthma; occupational rhinitis; inflammatory diseases

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APA (6^th Edition):

Patiwael, J. (2012). Interplay Between Allergy and Work. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/77064

Chicago Manual of Style (16^th Edition):

Patiwael, Jiska. “Interplay Between Allergy and Work.” 2012. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 12, 2021. http://hdl.handle.net/1765/77064.

MLA Handbook (7^th Edition):

Patiwael, Jiska. “Interplay Between Allergy and Work.” 2012. Web. 12 Apr 2021.

Vancouver:

Patiwael J. Interplay Between Allergy and Work. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2012. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/1765/77064.

Council of Science Editors:

Patiwael J. Interplay Between Allergy and Work. [Doctoral Dissertation]. Erasmus University Medical Center; 2012. Available from: http://hdl.handle.net/1765/77064

McMaster University

21. Hernandez, Jeremy M. ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS.

Degree: PhD, 2011, McMaster University

URL: http://hdl.handle.net/11375/11524

►

Asthma is a disease characterized by transient airway smooth muscle contraction leading to episodes of reversible airway narrowing. It affects over 300 million people… (more)

▼

Asthma is a disease characterized by transient airway smooth muscle contraction leading to episodes of reversible airway narrowing. It affects over 300 million people worldwide and is implicated in over 250 000 deaths annually. The primary clinical features of asthma include airway inflammation, hyperresponsiveness, and remodeling. Generally, asthmatic patients experience exacerbations between periods of diminished symptoms. Interestingly, in addition to these above mentioned hallmarks, asthmatics have also been shown to react differently to ventilatory mechanical strain. This is most evident when assessing the effect of a deep inspiration (DI), clinically measured as a breath taken from functional residual capacity to total lung capacity, in healthy individuals versus asthmatics. These deep inspiratory efforts have been shown to produce a bronchodilatory response in healthy individuals, whereas in asthmatics, DIs are less effective in producing bronchodilation, can cause more rapid airway re-narrowing, and even bronchoconstriction in moderate to severe asthmatics. The mechanism by which a DI is able to cause bronchoconstriction remains ambiguous. Previous theories suggest that this phenomenon is intrinsic to airway smooth muscle (ASM) itself. However, the airway inflammation present in asthmatic airways may also add to the increased ASM contractility following stretch, by the release of mediators that can prime the contractile apparatus to react excessively in the presence of stretch. Thus, collectively, the studies contained in this thesis are linked to the general theme of greater characterization of the signalling mechanisms that regulate airway stretch-activated contractions using a pharmacological approach in intact bovine bronchial segments, with the hope of providing novel insights into the mechanisms that regulate the DI-induced bronchoconstriction seen in asthmatics.

Doctor of Philosophy (Medical Science)

Advisors/Committee Members: Janssen, Luke J., Inman, Mark, Cox, Gerard, Medical Sciences (Division of Physiology/Pharmacology).

Subjects/Keywords: asthma; airway smooth muscle contraction; deep inspiration; bronchoconstriction; airway stretch; airway hyperresponsiveness; Circulatory and Respiratory Physiology; Medical Physiology; Physiological Processes; Respiratory Tract Diseases; Circulatory and Respiratory Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hernandez, J. M. (2011). ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/11524

Chicago Manual of Style (16^th Edition):

Hernandez, Jeremy M. “ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS.” 2011. Doctoral Dissertation, McMaster University. Accessed April 12, 2021. http://hdl.handle.net/11375/11524.

MLA Handbook (7^th Edition):

Hernandez, Jeremy M. “ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS.” 2011. Web. 12 Apr 2021.

Vancouver:

Hernandez JM. ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS. [Internet] [Doctoral dissertation]. McMaster University; 2011. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/11375/11524.

Council of Science Editors:

Hernandez JM. ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS. [Doctoral Dissertation]. McMaster University; 2011. Available from: http://hdl.handle.net/11375/11524

22. Leonard, Kendra L. Bacterial co-infection in the Mojave Desert tortoise (Copherus agassizii) and its effect on upper respiratory tract disease.

Degree: MS(M.S.), Molecular Biology, 2018, Colorado State University – Pueblo

URL: http://hdl.handle.net/10217/192150

► Some species of Pasteurella are known to cause disease in vertebrates, often within the respiratory system, and in association with Mycoplasma. While Mycoplasma agassizii is… (more)

Subjects/Keywords: Mycoplasma agassizii; Pasteurella testudinis; upper respiratory tract disease; co-infection; Desert tortoise – Infections – Mojave Desert; Mycoplasma; Pasteurella; Respiratory organs – Diseases; Respiratory infections

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APA (6^th Edition):

Leonard, K. L. (2018). Bacterial co-infection in the Mojave Desert tortoise (Copherus agassizii) and its effect on upper respiratory tract disease. (Masters Thesis). Colorado State University – Pueblo. Retrieved from http://hdl.handle.net/10217/192150

Chicago Manual of Style (16^th Edition):

Leonard, Kendra L. “Bacterial co-infection in the Mojave Desert tortoise (Copherus agassizii) and its effect on upper respiratory tract disease.” 2018. Masters Thesis, Colorado State University – Pueblo. Accessed April 12, 2021. http://hdl.handle.net/10217/192150.

MLA Handbook (7^th Edition):

Leonard, Kendra L. “Bacterial co-infection in the Mojave Desert tortoise (Copherus agassizii) and its effect on upper respiratory tract disease.” 2018. Web. 12 Apr 2021.

Vancouver:

Leonard KL. Bacterial co-infection in the Mojave Desert tortoise (Copherus agassizii) and its effect on upper respiratory tract disease. [Internet] [Masters thesis]. Colorado State University – Pueblo; 2018. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10217/192150.

Council of Science Editors:

Leonard KL. Bacterial co-infection in the Mojave Desert tortoise (Copherus agassizii) and its effect on upper respiratory tract disease. [Masters Thesis]. Colorado State University – Pueblo; 2018. Available from: http://hdl.handle.net/10217/192150

23. Shapiro, Susan E. The index of respiratory distress : a clinical decision rule to assist out-of-hospital providers in caring for older patients in respiratory distress.

Degree: PhD, 2003, Oregon Health Sciences University

URL: doi:10.6083/M4J38QT9 ; http://digitalcommons.ohsu.edu/etd/3115

Subjects/Keywords: Aged; Respiratory Tract Diseases – nursing; Decision Support Techniques

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shapiro, S. E. (2003). The index of respiratory distress : a clinical decision rule to assist out-of-hospital providers in caring for older patients in respiratory distress. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4J38QT9 ; http://digitalcommons.ohsu.edu/etd/3115

Chicago Manual of Style (16^th Edition):

Shapiro, Susan E. “The index of respiratory distress : a clinical decision rule to assist out-of-hospital providers in caring for older patients in respiratory distress.” 2003. Doctoral Dissertation, Oregon Health Sciences University. Accessed April 12, 2021. doi:10.6083/M4J38QT9 ; http://digitalcommons.ohsu.edu/etd/3115.

MLA Handbook (7^th Edition):

Shapiro, Susan E. “The index of respiratory distress : a clinical decision rule to assist out-of-hospital providers in caring for older patients in respiratory distress.” 2003. Web. 12 Apr 2021.

Vancouver:

Shapiro SE. The index of respiratory distress : a clinical decision rule to assist out-of-hospital providers in caring for older patients in respiratory distress. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2003. [cited 2021 Apr 12]. Available from: doi:10.6083/M4J38QT9 ; http://digitalcommons.ohsu.edu/etd/3115.

Council of Science Editors:

Shapiro SE. The index of respiratory distress : a clinical decision rule to assist out-of-hospital providers in caring for older patients in respiratory distress. [Doctoral Dissertation]. Oregon Health Sciences University; 2003. Available from: doi:10.6083/M4J38QT9 ; http://digitalcommons.ohsu.edu/etd/3115

24. Menard, Kathleen J. Experience of Women with a Diagnosis of Obstructive Sleep Apnea (OSA): A Dissertation.

Degree: 2015, U of Massachusetts : Nursing

URL: 10.13028/721d-2s16 ; https://escholarship.umassmed.edu/gsn_diss/36

► This qualitative descriptive (QD) study examined the experience of the woman newly diagnosed with obstructive sleep apnea (OSA). The study employed Leventhal’s Self- Regulatory… (more)

▼ This qualitative descriptive (QD) study examined the experience of the woman newly diagnosed with obstructive sleep apnea (OSA). The study employed Leventhal’s Self- Regulatory Theory to understand women’s illness representation of OSA, cognitive and emotional coping, and situational appraisal skills in coming to terms with OSA. The specific aims were to: 1) Describe the illness representation of women with a recent diagnosis (within one year) of OSA; 2) Describe the cognitive perceptions and emotional response to diagnosis and treatment of OSA in this sample of women; and, 3) Describe the meaning of OSA and the coping strategies used by this sample of women. The overarching theme of this study of a life-altering diagnosis required participants to process the health threatening information in both a conceptual and concrete process for dealing with both the physical and emotional aspects. The first two subthemes that emerged were Making sense of it, and Making it work as the women came to terms with their symptoms, diagnosis, and adapted to their treatment. For this sample of women, both acceptance (acknowledging the diagnosis of OSA and embracing treatment), and denial (not convinced of diagnosis or need for treatment, seeking alternatives) were factors in how they made sense of the situation. The making it work subtheme dealt with the women’s experiences adapting to treatment both physically and emotionally, including the appraisal, reconsideration and adjustments when they encountered difficulties and delays. A fluid iterative process included women participants describing how they appraised their situation often moving back and forth between acceptance, denial, seeking alternatives, struggling with treatment and moving forward. In both of these subthemes, family support and the stigma of OSA and CPAP were involved in how the women accepted and adapted to treatment. The third subtheme that emerged was Paying it forward as many women felt the obligation to help themselves by adapting a healthier lifestyle for themselves, their families and to assist others impacted by OSA. Women spoke of paying it forward by offering information and support to others not yet diagnosed, or are struggling with diagnosis and treatment. Many of these women were staunch advocates for other women to be tested, for HCPs to be more aware, to be more attuned to women’s sleep history, and to refer women for treatment. Implications of these findings include enhancing recognition and awareness by women of OSA symptoms, the need for diagnostic evaluation, and partner awareness as an important component of diagnosis and successful treatment for women. Study findings support recognition of women’s presentation of OSA including unusual symptoms for earlier diagnosis and treatment. Sleep partner awareness and support appear to be relevant to women in acceptance of a life altering diagnosis. Further exploration of modifiable factors such as prompt diagnosis and individualized treatment of women with OSA could also impact potential… Advisors/Committee Members: Jean Boucher.

Subjects/Keywords: Sleep Apnea; Obstructive; Women's Health; Emotional Adjustment; Behavior and Behavior Mechanisms; Mental and Social Health; Nursing; Respiratory Tract Diseases; Women's Health

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APA (6^th Edition):

Menard, K. J. (2015). Experience of Women with a Diagnosis of Obstructive Sleep Apnea (OSA): A Dissertation. (Thesis). U of Massachusetts : Nursing. Retrieved from 10.13028/721d-2s16 ; https://escholarship.umassmed.edu/gsn_diss/36

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Menard, Kathleen J. “Experience of Women with a Diagnosis of Obstructive Sleep Apnea (OSA): A Dissertation.” 2015. Thesis, U of Massachusetts : Nursing. Accessed April 12, 2021. 10.13028/721d-2s16 ; https://escholarship.umassmed.edu/gsn_diss/36.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Menard, Kathleen J. “Experience of Women with a Diagnosis of Obstructive Sleep Apnea (OSA): A Dissertation.” 2015. Web. 12 Apr 2021.

Vancouver:

Menard KJ. Experience of Women with a Diagnosis of Obstructive Sleep Apnea (OSA): A Dissertation. [Internet] [Thesis]. U of Massachusetts : Nursing; 2015. [cited 2021 Apr 12]. Available from: 10.13028/721d-2s16 ; https://escholarship.umassmed.edu/gsn_diss/36.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Menard KJ. Experience of Women with a Diagnosis of Obstructive Sleep Apnea (OSA): A Dissertation. [Thesis]. U of Massachusetts : Nursing; 2015. Available from: 10.13028/721d-2s16 ; https://escholarship.umassmed.edu/gsn_diss/36

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Mato Grosso do Sul

25. Souza, Amaury de. A influência das variáveis ambientais (meteorológicas e de qualidade do ar) na morbidade respiratória na cidade de Campo Grande - MS .

Degree: 2013, Universidade Federal de Mato Grosso do Sul

URL: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2181

► O conhecimento antecipado das condições meteorológicas pode ajudar a sociedade a evitar a degradação da natureza assim como prevenir doenças do aparelho respiratório. O objetivo… (more)

Subjects/Keywords: Doenças Respiratórias; Ar - poluição; Conceitos Meteorológicos; Distribuição de Poisson; Respiratory Tract Diseases; Meteorological Concepts; Poisson Distribution; Campo Grande (MS)

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APA (6^th Edition):

Souza, A. d. (2013). A influência das variáveis ambientais (meteorológicas e de qualidade do ar) na morbidade respiratória na cidade de Campo Grande - MS . (Thesis). Universidade Federal de Mato Grosso do Sul. Retrieved from http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2181

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Souza, Amaury de. “A influência das variáveis ambientais (meteorológicas e de qualidade do ar) na morbidade respiratória na cidade de Campo Grande - MS .” 2013. Thesis, Universidade Federal de Mato Grosso do Sul. Accessed April 12, 2021. http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2181.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Souza, Amaury de. “A influência das variáveis ambientais (meteorológicas e de qualidade do ar) na morbidade respiratória na cidade de Campo Grande - MS .” 2013. Web. 12 Apr 2021.

Vancouver:

Souza Ad. A influência das variáveis ambientais (meteorológicas e de qualidade do ar) na morbidade respiratória na cidade de Campo Grande - MS . [Internet] [Thesis]. Universidade Federal de Mato Grosso do Sul; 2013. [cited 2021 Apr 12]. Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2181.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Souza Ad. A influência das variáveis ambientais (meteorológicas e de qualidade do ar) na morbidade respiratória na cidade de Campo Grande - MS . [Thesis]. Universidade Federal de Mato Grosso do Sul; 2013. Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2181

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Mônica Vasconcelos de Moraes. Função pulmonar dos trabalhadores da fundição de metais em uma indústria metalúrgica.

Degree: 2011, UNIVERSIDADE CIDADE DE SÃO PAULO

URL: http://bdtd.unicid.br/tde_busca/arquivo.php?codArquivo=204

►

Introdução: A metalurgia caracteriza-se pela manipulação dos metais desde sua extração até a formação de materiais para uso em geral. No processo de confecção das… (more)

▼

Introdução: A metalurgia caracteriza-se pela manipulação dos metais desde sua extração até a formação de materiais para uso em geral. No processo de confecção das peças metálicas, os metais são submetidos a procedimentos de fundição, onde são derretidos e moldados de acordo com as necessidades. A fundição dos metais envolve um processo de alto risco ocupacional aos colaboradores envolvidos, já que estes são expostos aos metais na forma de pó ou pequenas partículas e a vapores e altas temperaturas, no momento da fundição. Embora os equipamentos de proteção individual influenciem a exposição e o risco ocupacional, a inalação das partículas com subsequente prejuízo da função pulmonar, podem gerar uma série de doenças respiratórias. Objetivo: Avaliar o impacto da inalação dos gases, poluentes e da alta temperatura na função pulmonar dos colaboradores de uma indústria metalúrgica. Métodos: Foi realizado um estudo transversal com todos os colaboradores de uma indústria metalúrgica na cidade de Guarulhos-SP que trabalhavam diretamente no processo de fundição de metais. Dos indivíduos foi questionada a sua história clínica, hábitos de vida e realizadas avaliações espirométricas e pico de fluxo expiratório. Resultados: Os 63 colaboradores avaliados apresentaram uma faixa etária entre 18 a 59 anos, com média de idade de 33,98 8,25 anos e a média de anos trabalhados na atividade atual foi de 6,076,47 anos. De todos os colaboradores avaliados, apenas 7,93% relataram doenças respiratórias prévias e quanto à carga tabagística, apenas 14,28% dos colaboradores eram fumantes. Em relação à espirometria, os colaboradores apresentaram média de CVF de 9518% do previsto, VEF1 de 95,0615,83% do previsto, além de uma média de 0,820,09 da relação VEF1/CVF. O pico de fluxo expiratório dos colaboradores foi em média 502,06 120,74 L/min. Conclusão As provas espirométricas e de pico de fluxo expiratório dentro dos valores preditos se justificam pela média de idade dos colaboradores, bem como pela baixa média de anos trabalhados na atividade de fundição associados ainda à ausência de co-morbidades

Introduction: Metallurgy is the science of the manipulation of metals from their extraction to the formation of material for general use. During the manufacturing process, metal is subjected to casting procedures, such as melting and molding. The casting of metal involves a high occupational risk to employees involved, as they are exposed to metals in the form of powder or small particles and vapors, and high temperatures at the time of casting. The risks to which employees are exposed include inhalation of particles with subsequent loss of lung function, leading to a variety of respiratory diseases. Although the protective equipments influence the risk exposure and the occupational inhalation of particles with subsequent loss of lung function can generate a variety of respiratory diseases. Objective: To evaluate the impact of the inhalation of gases and pollutants and the high temperatures on pulmonary function of workers in the metallurgical…

Advisors/Committee Members: Luciana Dias Chiavegato, Rosimeire Simprini Padula.

Subjects/Keywords: Doenças respiratórias; Riscos ocupacionais; Fundição; Metais; Respiratory tract diseases; Occupational risks; Casting; Metals; FISIOTERAPIA E TERAPIA OCUPACIONAL

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moraes, M. V. d. (2011). Função pulmonar dos trabalhadores da fundição de metais em uma indústria metalúrgica. (Thesis). UNIVERSIDADE CIDADE DE SÃO PAULO. Retrieved from http://bdtd.unicid.br/tde_busca/arquivo.php?codArquivo=204

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moraes, Mônica Vasconcelos de. “Função pulmonar dos trabalhadores da fundição de metais em uma indústria metalúrgica.” 2011. Thesis, UNIVERSIDADE CIDADE DE SÃO PAULO. Accessed April 12, 2021. http://bdtd.unicid.br/tde_busca/arquivo.php?codArquivo=204.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moraes, Mônica Vasconcelos de. “Função pulmonar dos trabalhadores da fundição de metais em uma indústria metalúrgica.” 2011. Web. 12 Apr 2021.

Vancouver:

Moraes MVd. Função pulmonar dos trabalhadores da fundição de metais em uma indústria metalúrgica. [Internet] [Thesis]. UNIVERSIDADE CIDADE DE SÃO PAULO; 2011. [cited 2021 Apr 12]. Available from: http://bdtd.unicid.br/tde_busca/arquivo.php?codArquivo=204.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moraes MVd. Função pulmonar dos trabalhadores da fundição de metais em uma indústria metalúrgica. [Thesis]. UNIVERSIDADE CIDADE DE SÃO PAULO; 2011. Available from: http://bdtd.unicid.br/tde_busca/arquivo.php?codArquivo=204

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Lin, Ling. Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation.

Degree: Interdisciplinary Graduate Program, Molecular, Cell and Cancer Biology, 2012, U of Massachusetts : Med

URL: https://escholarship.umassmed.edu/gsbs_diss/610

► The development of methods and techniques is the driving force of scientific research. In this work, we described two large-scale screens in studying transcriptional… (more)

▼ The development of methods and techniques is the driving force of scientific research. In this work, we described two large-scale screens in studying transcriptional activation and tumor suppression. In Part I, we studied transcriptional activation mechanisms by deriving and characterizing activation defective mutants. Promoter-specific transcriptional activators stimulate transcription through direct interactions with one or more components of the transcription machinery, termed the “target.” The identification of direct in vivo targets of activators has been a major challenge. We perform a large-scale genetic screen to derive and characterize tra1 alleles that are selectively defective for interaction with Gal4 in vivo. Utilizing these mutants, we demonstrated that Tra is an essential target for Gal4 activation, Gal4 and Tra1 bind cooperatively at the promoter and the Gal4–Tra1 interaction occurs predominantly on the promoter. In addition, we demonstrated that the Gal4-interaction site on Tra1 is highly selective. In Part II, we described a functional genomics approach to discover new tumor suppressor genes. A goal of contemporary cancer research is to identify the genes responsible for neoplastic transformation. Cells that are immortalized but non-tumorigenic were stably transduced with pools of short hairpin RNAs (shRNAs) and tested for their ability to form tumors in mice. ShRNAs in any resulting tumors were identified by sequencing to reveal candidate TSGs, which were then validated both experimentally and clinically by analysis of human tumor samples. Using this approach, we identified and validated 33 candidate TSGs. We found that most candidate TSGs were down-regulated in >70% of human lung squamous cell carcinoma (hLSCC) samples, and 17 candidate TSGs negatively regulate FGFR signalling pathway, and their ectopic expression inhibited growth of hLSCC xenografts. Furthermore, we suggest that by examining at the expression level of TSGs in lung cancer patients, we can predict their drug responsiveness to FGFR inhibitors. In conclusion, we have identified many new lung squamous cell cancer TSGs, using an experimental strategy that can be broadly applied to find TSGs in other tumor types. Advisors/Committee Members: Michael R. Green.

Subjects/Keywords: Transcriptional Activation; Genes; Tumor Suppressor; Cells; Genetic Phenomena; Genetics and Genomics; Neoplasms; Nucleic Acids, Nucleotides, and Nucleosides; Respiratory Tract Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, L. (2012). Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/610

Chicago Manual of Style (16^th Edition):

Lin, Ling. “Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation.” 2012. Doctoral Dissertation, U of Massachusetts : Med. Accessed April 12, 2021. https://escholarship.umassmed.edu/gsbs_diss/610.

MLA Handbook (7^th Edition):

Lin, Ling. “Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation.” 2012. Web. 12 Apr 2021.

Vancouver:

Lin L. Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2012. [cited 2021 Apr 12]. Available from: https://escholarship.umassmed.edu/gsbs_diss/610.

Council of Science Editors:

Lin L. Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2012. Available from: https://escholarship.umassmed.edu/gsbs_diss/610

Edith Cowan University

28. Cross, Martyn. Occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site.

Degree: 2011, Edith Cowan University

URL: https://ro.ecu.edu.au/theses/418

► This thesis outlines the results of occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site. The research was conducted as part of a… (more)

▼ This thesis outlines the results of occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site. The research was conducted as part of a collaborative agreement between Edith Cowan University and Minara Resources, the overarching title of which was ‗Establishing best practice protocols in the management of occupational and environmental health in a high-risk mining and ore-processing environment‘. To form the basis of this research it was hypothesised that although the chemical hazards had been adequately identified, and the occupational exposures in each work area at Murrin Murrin were generally well below their respective occupational exposure levels, it was still possible that additive, or even synergistic biological effects could cause adverse respiratory health effects due to the exposure to a combination of these atmospheric contaminants. This was the perception and a concern voiced by the Murrin Murrin workforce. Therefore, in working through the hypothesis, a literature review concentrating on the gaps in current knowledge and research for the early detection of occupational respiratory diseases was conducted, and the research tool and experiment design determined. The case for using pulmonary function tests in conjunction with a respiratory questionnaire in assessing early respiratory changes due to occupational exposures was established. Over a period between 17 February 2004 and 21 June 2006, a longitudinal study was conducted to ascertain the prevalence of respiratory symptoms and lung function of employees at the Murrin Murrin Operation, and compared with a local control group consisting of catering staff who resided at the accommodation camp approximately eight kilometres from the mine site. Lung function data were also compared to established predicted normal values from a reference population with normal lung function. Lung function data were analysed to determine whether there was an effect due to the area worked, and the employee‘s length of service. The lung function parameters of the study group, corrected for age and height were compared using linear regression analysis with both the control group and the predicted normal values. Repeat lung function tests were conducted on a sample of the original study group approximately two years after the initial study and statistically analysed to determine whether there was an effect on lung function over this time period. In addition, lung function tests were conducted for a cohort of refinery workers at the start and end of their two-week work period to determine whether there was a before-and-after effect due to their working conditions. The prevalence of respiratory symptoms was less in the study group compared to the controls; and these respiratory symptoms were determined to be non-work-related. On statistical analysis, for the ‗presumed healthy‘ workers (minus the smokers and those with known non-work-related respiratory symptoms) there was no overall decrement in lung function. Similarly, there was no overall…

Subjects/Keywords: lung Function; Industrial safety; Leonora Region; Pulmonary function tests; Occupational Health and Industrial Hygiene; Respiratory Tract Diseases

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APA (6^th Edition):

Cross, M. (2011). Occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site. (Thesis). Edith Cowan University. Retrieved from https://ro.ecu.edu.au/theses/418

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cross, Martyn. “Occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site.” 2011. Thesis, Edith Cowan University. Accessed April 12, 2021. https://ro.ecu.edu.au/theses/418.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cross, Martyn. “Occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site.” 2011. Web. 12 Apr 2021.

Vancouver:

Cross M. Occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site. [Internet] [Thesis]. Edith Cowan University; 2011. [cited 2021 Apr 12]. Available from: https://ro.ecu.edu.au/theses/418.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cross M. Occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site. [Thesis]. Edith Cowan University; 2011. Available from: https://ro.ecu.edu.au/theses/418

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Medical Center

29. Collum, Scott Dale. ROLE OF NUDT21 MEDIATED ALTERNATIVE POLYADENYLATION AND HYALURONAN IN THE DEVELOPMENT OF PULMONARY HYPERTENSION.

Degree: PhD, 2019, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/962

► Pulmonary hypertension (PH) is a progressive disease with serious effects on quality of life and life expectancy of patients. PH is a complex disease… (more)

Subjects/Keywords: Pulmonary Hypertension; Alternative Polyadenylation; APA; Hyaluronan; HAS2; Combined Pulmonary Fibrosis and Emphysema; CPFE; HA; Medicine and Health Sciences; Respiratory Tract Diseases

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APA (6^th Edition):

Collum, S. D. (2019). ROLE OF NUDT21 MEDIATED ALTERNATIVE POLYADENYLATION AND HYALURONAN IN THE DEVELOPMENT OF PULMONARY HYPERTENSION. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/962

Chicago Manual of Style (16^th Edition):

Collum, Scott Dale. “ROLE OF NUDT21 MEDIATED ALTERNATIVE POLYADENYLATION AND HYALURONAN IN THE DEVELOPMENT OF PULMONARY HYPERTENSION.” 2019. Doctoral Dissertation, Texas Medical Center. Accessed April 12, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/962.

MLA Handbook (7^th Edition):

Collum, Scott Dale. “ROLE OF NUDT21 MEDIATED ALTERNATIVE POLYADENYLATION AND HYALURONAN IN THE DEVELOPMENT OF PULMONARY HYPERTENSION.” 2019. Web. 12 Apr 2021.

Vancouver:

Collum SD. ROLE OF NUDT21 MEDIATED ALTERNATIVE POLYADENYLATION AND HYALURONAN IN THE DEVELOPMENT OF PULMONARY HYPERTENSION. [Internet] [Doctoral dissertation]. Texas Medical Center; 2019. [cited 2021 Apr 12]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/962.

Council of Science Editors:

Collum SD. ROLE OF NUDT21 MEDIATED ALTERNATIVE POLYADENYLATION AND HYALURONAN IN THE DEVELOPMENT OF PULMONARY HYPERTENSION. [Doctoral Dissertation]. Texas Medical Center; 2019. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/962

Universidade Nova

30. Martins, Pedro Miguel Carvalho Diogo Carreiro . Mecanismos de inflamação brônquica resultantes da exposição a factores ambientais.

Degree: 2012, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8339

► RESUMO Tratando-se a asma de uma doença respiratória, desde há várias décadas que tem sido abordada a hipótese de que factores ambientais, nomeadamente os relacionados… (more)

▼ RESUMO Tratando-se a asma de uma doença respiratória, desde há várias décadas que tem sido abordada a hipótese de que factores ambientais, nomeadamente os relacionados com a qualidade do ar inalado, possam contribuir para o seu agravamento. Para além dos aeroalergenos, outros factores ambientais como a poluição atmosférica estarão associados às doenças respiratórias. O ar respirado contém uma variedade de poluentes atmosféricos, provenientes quer de fontes naturais quer de origem antropogénica, nomeadamente de actividades industriais, domésticas ou das emissões de veículos. Estes poluentes, tradicionalmente considerados como um problema de foro ambiental, têm sido cada vez mais encarados como um problema de saúde pública. Também a qualidade do ar interior, tem sido associada a queixas respiratórias, não só em termos ocupacionais mas também em exposições domésticas. Dentro dos principais poluentes, encontramos a matéria particulada (como as PM10), o O3, NO2, e os compostos orgânicos voláteis (COVs). Se é verdade que os três primeiros têm como principais fontes de exposição a combustão fóssil associada aos veículos automóveis, já os COVs (como o benzeno, tolueno, xileno, etilbenzeno e formaldeído) são poluentes mais característicos do ar interior. Os mecanismos fisiopatológicos subjacentes à agressão dos poluentes do ar não se encontram convenientemente esclarecidos. Pensa-se que após a sua inalação, induzam um grau crescente de stress oxidativo que será responsável pelo desenvolvimento da inflamação das vias aéreas. A progressão do stress oxidativo e da inflamação, associarse- ão posteriormente a lesão local (pulmonar) e sistémica. Neste trabalho pretendeu-se avaliar os efeitos da exposição individual a diversos poluentes, do ar exterior e interior, sobre as vias aéreas, recorrendo a parâmetros funcionais, inflamatórios e do estudo do stress oxidativo. Neste sentido, desenvolveu-se um estudo de painel na cidade de Viseu, em que foram acompanhadas durante 18 meses, 51 crianças com história de sibilância, identificadas pelo questionário do estudo ISAAC. As crianças foram avaliadas em quatro Visitas (quatro medidas repetidas), através de diversos exames, que incluíram execução de espirometria com broncodilatação, medição ambulatória do PEF, medição de FENO e estudo do pH no condensado brônquico do ar exalado. O estudo dos 8-isoprostanos no condensado brônquico foi efectuado somente em duas Visitas, e o do doseamento de malonaldeído urinário somente na última Visita. Para além da avaliação do grau de infestação de ácaros do pó do colchão, para cada criança foi calculado o valor de exposição individual a PM10, O3, NO2, benzeno, tolueno, xileno, etilbenzeno e formaldeído, através de uma complexa metodologia que envolveu técnicas de modelação associadas a medições directas do ar interior (na casa e escola da criança) e do ar exterior. Para a análise de dados foram utilizadas equações de estimação generalizadas com uma matriz de correlação de trabalho uniforme, com excepção do estudo das associações entre poluentes,…

Subjects/Keywords: Respiratory Tract Diseases ; Air Pollutants - adverse effects; Airway Obstruction - physiopathology ; Oxidative Stress - physiology ; Children ; Case-Control Studies; Questionnaires; Fisiopatologia

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APA (6^th Edition):

Martins, P. M. C. D. C. (2012). Mecanismos de inflamação brônquica resultantes da exposição a factores ambientais. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martins, Pedro Miguel Carvalho Diogo Carreiro . “Mecanismos de inflamação brônquica resultantes da exposição a factores ambientais.” 2012. Thesis, Universidade Nova. Accessed April 12, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martins, Pedro Miguel Carvalho Diogo Carreiro . “Mecanismos de inflamação brônquica resultantes da exposição a factores ambientais.” 2012. Web. 12 Apr 2021.

Vancouver:

Martins PMCDC. Mecanismos de inflamação brônquica resultantes da exposição a factores ambientais. [Internet] [Thesis]. Universidade Nova; 2012. [cited 2021 Apr 12]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martins PMCDC. Mecanismos de inflamação brônquica resultantes da exposição a factores ambientais. [Thesis]. Universidade Nova; 2012. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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