You searched for subject:(Repair)
.
Showing records 1 – 30 of
3679 total matches.
◁ [1] [2] [3] [4] [5] … [123] ▶

Wake Forest University
1.
Wang, Rui.
INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION.
Degree: 2015, Wake Forest University
URL: http://hdl.handle.net/10339/57276
► The spine may become unstable and fragile due to aging, trauma, or congenital defects. The instability of the spine potentially causes compression on the spinal…
(more)
▼ The spine may become unstable and fragile due to aging, trauma, or congenital defects. The instability of the spine potentially causes compression on the spinal cord, which leads to permanent damage and paralysis. In order to reduce the risk of functional impairment, the current surgical treatment is spinal fusion. Spinal fusion is the most common operating room (OR) procedure among all age groups. However, the procedure has the highest total OR cost in the United States, and the high failure rate is due to non-union (Weiss et al. 2014, Rajaee et al. 2012, Stranges et al. 2009). Negative pressure wound therapy (NPWT) or vacuum assisted closure (VAC) has shown superior clinical results when used in combination with biomaterials to accelerate wound healing in treating complicated wound with exposed bone (Wijewardena et al. 2011, DeFranzo et al. 2001). However, NPWT is not established as a treatment modality for orthopedic application and its mechanistic pathways of action on cellular activities is unknown. To support proper bone healing, the goal of this study is to test the central hypothesis that an elastic osteoid mimetic bone repair material fabricated by electrospinning using composites of type I collagen (Col I), poly (1,8-octanediol citrate) (POC), and chondroitin 6-sulfate (CS) named material (BRM), or subatmospheric pressure, or synergy of both promote osteoblast proliferation and osteogenic differentiation. Results indicated that osteoblast proliferation significantly increased when cultured under subatmospheric pressure. The osteogenic gene expression of Runx2, OSX, ALP, OPN, COL1A2, and HIF-1α were elevated in fully differentiated bone marrow mesenchymal stem cells (MSCs), which were cultured on BRM and treated with subatmospheric pressure. When BRM and/or NPWT were implemented in rabbit and sheep models, the bone repair measured from CT images provided evidences for feasibly applying NPWT to repair bone with BRM electrospun materials. The in vitro and in vivo systems in this study suggest that there is a significant interaction of using BRM with NPWT for osteogenesis. Developing biomaterials with affinity to cells and soluble factors driven by pressure gradient could ultimately translate to safe and cost-effective clinical applications that accelerate bone healing for spinal fusion.
Subjects/Keywords: Bone Repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wang, R. (2015). INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57276
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Rui. “INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION.” 2015. Thesis, Wake Forest University. Accessed April 12, 2021.
http://hdl.handle.net/10339/57276.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Rui. “INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION.” 2015. Web. 12 Apr 2021.
Vancouver:
Wang R. INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/10339/57276.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang R. INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57276
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University
2.
Rodriguez-Colon, Lizahira, 1987-.
Role of G9a methyltransferase in the dna damage response signal.
Degree: PhD, Pharmacology, Cellular and Molecular, 2018, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57687/
► DNA damage induces a choreographed set of local changes in histone modifications which leads to efficient recruitment of DNA repair factors. The regulation of these…
(more)
▼ DNA damage induces a choreographed set of local changes in histone modifications which leads to efficient recruitment of DNA repair factors. The regulation of these chromatin modifications at DNA breaks is critical to maintain genome integrity. Recent studies in our lab have identified a role for G9a methyltransferase in regulating DNA repair. The overall aim of this project was to elucidate how G9a activity regulates this pathway and to identify the effects of its inhibition in this process. It was shown that G9a localizes to sites of DNA damage in an ATM-dependent fashion and that inhibition of G9a activity affects early recruitment of multiple DNA repair factors. We found that catalytic inhibition of G9a using UNC0638 results in increased ATM activation. This led to increased "spreading" of pH2AX and MDC1 signals seen at regions of localized DNA breaks induced by UV-laser scissors, which was dependent upon ATM activation. This was also associated with increased levels of H3K36me2 and H3K56Ac. Biochemical data showed that G9a interacts and regulates HDAC1/2 activity during the DNA damage response. G9a inhibition led to decreased HDAC1 methylation, and increased ATM acetylation. These data suggest that G9a activity regulates the extent of ATM activation induced by DNA breaks and is required for efficient recruitment of downstream DNA repair factors. Overall our data suggests that G9a plays a critical role in regulation of ATM-dependent signaling during the DNA damage response and raises the possibility of using G9a inhibitors in the clinical setting as part of novel cancer therapies.
Advisors/Committee Members: Xia, Bing (chair), Pine, Sharon (internal member), Ganesan, Shridar (internal member), Langer, Jerome (outside member), School of Graduate Studies.
Subjects/Keywords: DNA repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rodriguez-Colon, Lizahira, 1. (2018). Role of G9a methyltransferase in the dna damage response signal. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57687/
Chicago Manual of Style (16th Edition):
Rodriguez-Colon, Lizahira, 1987-. “Role of G9a methyltransferase in the dna damage response signal.” 2018. Doctoral Dissertation, Rutgers University. Accessed April 12, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/57687/.
MLA Handbook (7th Edition):
Rodriguez-Colon, Lizahira, 1987-. “Role of G9a methyltransferase in the dna damage response signal.” 2018. Web. 12 Apr 2021.
Vancouver:
Rodriguez-Colon, Lizahira 1. Role of G9a methyltransferase in the dna damage response signal. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Apr 12].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57687/.
Council of Science Editors:
Rodriguez-Colon, Lizahira 1. Role of G9a methyltransferase in the dna damage response signal. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57687/

University of Texas – Austin
3.
Malik, Muhammad Zubair.
Combining data structure repair and program repair.
Degree: PhD, Electrical and Computer Engineering, 2014, University of Texas – Austin
URL: http://hdl.handle.net/2152/26034
► Bugs in code continue to pose a fundamental problem for software reliability and cause expensive failures. The process of removing known bugs is termed debugging,…
(more)
▼ Bugs in code continue to pose a fundamental problem for software reliability and cause expensive failures. The process of removing known bugs is termed debugging, which is a classic methodology commonly performed before code is deployed. Traditionally, debugging is tedious, often requiring much manual effort. A more recent technique that complements debugging is data structure
repair, which handles bugs that make it to deployed systems and lead to erroneous behavior at runtime by modifying erroneous program states to recover from errors. While data structure
repair presents a promising basis for dealing with bugs at runtime, it remains computationally expensive. Our thesis is that debugging and data structure
repair can be integrated to provide the basis of an effective approach for removing bugs before code is deployed and handling them after it is deployed. We present a bi-directional integration where ideas at the basis of data structure
repair assist in automating debugging and vice versa. Our key insight is two-fold: (1)a
repair action performed to mutate an erroneous object field value to
repair it can be abstracted into a program statement that performs that update correctly; and (2)
repair actions that are performed repeatedly to fix the same error can be memoized and re-used. We design, develop, and evaluate two techniques that embody our insight. One, we present an automated debugging technique that leverages a systematic constraint-based data structure
repair technique developed in previous work and provides suggestions on how to fix a faulty program. Two, we present
repair abstractions that are based on the same central ideas as in our automated debugging technique and memoize how an erroneous state was repaired, which enables prioritizing and re-using
repair actions when the same error occurs again. The focus of our work is programs that operate on structurally complex data, e.g., heap-allocated data structures that have complex structural integrity constraints, such as acyclicity. Checking such constraints plays a central role in the techniques that lay at the foundation of our work. These techniques require the user to provide the constraints, which poses a burden on the user. To facilitate the use of constraint-based techniques, we present a third technique to check constraint violations at runtime using graph spectra, which have been studied extensively by mathematicians to capture properties of graphs. We view the heap of an object-oriented program as an edge-labeled graph, which allows us to apply results from graph spectra theory. Experimental results show the effectiveness of using graph spectra as a basis of capturing structural properties of a class of commonly used data structures.
Advisors/Committee Members: Khurshid, Sarfraz (advisor).
Subjects/Keywords: Program repair; Data Structure repair; Graph spectra
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Malik, M. Z. (2014). Combining data structure repair and program repair. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/26034
Chicago Manual of Style (16th Edition):
Malik, Muhammad Zubair. “Combining data structure repair and program repair.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed April 12, 2021.
http://hdl.handle.net/2152/26034.
MLA Handbook (7th Edition):
Malik, Muhammad Zubair. “Combining data structure repair and program repair.” 2014. Web. 12 Apr 2021.
Vancouver:
Malik MZ. Combining data structure repair and program repair. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/2152/26034.
Council of Science Editors:
Malik MZ. Combining data structure repair and program repair. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/26034

Drexel University
4.
Atkins, Andrew James.
Predicting the effects of intracellular protein variation on base excision repair capacity in human cells.
Degree: 2012, Drexel University
URL: http://hdl.handle.net/1860/3765
► Base excision repair (BER) is one of the primary means by which cells cope with genotoxic stress and DNA damage. BER is carried out by…
(more)
▼ Base excision repair (BER) is one of the primary means by which cells cope with genotoxic stress and DNA damage. BER is carried out by a series of enzymes which excise a damaged base from a DNA strand and replace it with an undamaged base. The importance of BER to the maintenance of genomic integrity, cellular health, and the health of an individual cannot be overstated. Numerous diseases, particularly cancer, have been correlated to BER deficiencies in several ways. 1) Increased disease risk has been correlated to elevated levels of highly mutagenic lesions repaired exclusively by the BER pathway. Elevated tissue levels of reactive oxygen species (ROS) which generate such lesions has likewise been correlated to increased disease risk. 2) Some functional variants of BER enzymes have been shown to be correlated with elevated disease risk. 3) Tumor cells have been shown to express BER enzymes at altered levels compared to surrounding healthy tissue.Although the correlation between BER deficiency and disease risk has been thoroughly demonstrated it has not been well characterized. An unrepaired DNA lesion can lead to mutagenesis. Yet all cells cope with thousands of potentially mutagenic lesions each day, the majority of which are repaired without incident. Simply stated, mutagenesis can occur when a cell faces a damage load which exceeds its repair capacity. Therefore the need to characterize the quantitative relationships that govern repair capacity is central to understanding the development of diseases triggered by mutagenesis.To this end I have created a formal model of the BER pathway. To test the model, I established protocols for DNA damage measurement in cultured human cells using single cell gel electrophoresis (SCGE). I developed novel software for the quantitation of SCGE data. In order to measure the system response following a perturbation, I created three cell lines deficient in the critical BER enzyme polymerase β (polβ) using RNA interference (RNAi) on HEK 293t cells. Polβ knockdown was confirmed and quantified with Western blotting. Repair curves were generated for wild type and knockdown cell lines using SCGE. Model validity was tested by comparing model predictions and experimental results.
Ph.D., Biomedical Engineering – Drexel University, 2012
Advisors/Committee Members: Kriete, Andres.
Subjects/Keywords: Biomedical engineering; DNA repair; Base excision repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Atkins, A. J. (2012). Predicting the effects of intracellular protein variation on base excision repair capacity in human cells. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/3765
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Atkins, Andrew James. “Predicting the effects of intracellular protein variation on base excision repair capacity in human cells.” 2012. Thesis, Drexel University. Accessed April 12, 2021.
http://hdl.handle.net/1860/3765.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Atkins, Andrew James. “Predicting the effects of intracellular protein variation on base excision repair capacity in human cells.” 2012. Web. 12 Apr 2021.
Vancouver:
Atkins AJ. Predicting the effects of intracellular protein variation on base excision repair capacity in human cells. [Internet] [Thesis]. Drexel University; 2012. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1860/3765.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Atkins AJ. Predicting the effects of intracellular protein variation on base excision repair capacity in human cells. [Thesis]. Drexel University; 2012. Available from: http://hdl.handle.net/1860/3765
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah
5.
Richards, Jody Lyn.
Recognition and repair of DNA damage by bacterial adenine glycosylases.
Degree: MS;, Chemistry;, 2008, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959
► E. coli MutY is a base excision repair (BER) glycosylase that excises adenine mispaired opposite 7,8-dihydro-8-oxo-2'-deoxyguanine. MutY has helix-hairpin-helix and Gly/Pro-Asp structural motifs characteristic of…
(more)
▼ E. coli MutY is a base excision repair (BER) glycosylase that excises adenine mispaired opposite 7,8-dihydro-8-oxo-2'-deoxyguanine. MutY has helix-hairpin-helix and Gly/Pro-Asp structural motifs characteristic of the BER glycosylase superfamily. In addition, it has an iron-sulfur cluster that is critical for substrate binding and catalytic activity. In the absence of DNA this cluster is not redox active; however, in the presence of DNA, its redox potential shifts dramatically. Here, the effects of DNA binding on the 4Fe-4S cluster of MutY are analyzed by two spectroscopic methods: Electron Paramagnetic Resonance (EPR) and X-ray Absorption Spectroscopy (XAS). By EPR, no difference in levels of cluster oxidation is observed when MutY is bound to a DNA oligonucleotide duplex containing either a G:C or G:THF central base pair, despite much tighter binding of the latter. EPR also shows that oxidation of the cluster is affected by the identity of the oxidant presented. XAS on MutY bound to DNA shows an increase in covalency of the Fe-S bonds relative to the cluster in the absence of DNA. MutY from a thermophilic bacterium B. stearothermophilus (BsMY) was expressed, purified, and characterized kinetically. Its glycosylase activity showed both temperature and salt dependence. In addition, BsMY discriminated more stringently than E. coli MutY between OG:A and G:A substrates.
Subjects/Keywords: DNA repair; Adenine
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Richards, J. L. (2008). Recognition and repair of DNA damage by bacterial adenine glycosylases. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959
Chicago Manual of Style (16th Edition):
Richards, Jody Lyn. “Recognition and repair of DNA damage by bacterial adenine glycosylases.” 2008. Masters Thesis, University of Utah. Accessed April 12, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959.
MLA Handbook (7th Edition):
Richards, Jody Lyn. “Recognition and repair of DNA damage by bacterial adenine glycosylases.” 2008. Web. 12 Apr 2021.
Vancouver:
Richards JL. Recognition and repair of DNA damage by bacterial adenine glycosylases. [Internet] [Masters thesis]. University of Utah; 2008. [cited 2021 Apr 12].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959.
Council of Science Editors:
Richards JL. Recognition and repair of DNA damage by bacterial adenine glycosylases. [Masters Thesis]. University of Utah; 2008. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959
6.
Schermerhorn, Kelly.
A Kinetic Perspective on DNA Base Excision Repair.
Degree: PhD, Chemistry, 2014, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:386264/
► The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β)…
(more)
▼ The DNA base excision
repair (BER) pathway is
compromised of several enzymes, including DNA glycosylases,
apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β
(pol β) and a DNA ligase, and is responsible for repairing single
nucleobase and AP site lesions. These enzymes must complete their
required task and coordinate with one another to faithfully
repair
DNA. Deficiencies and incorrect coordination of BER enzymes has
been linked to development of several cancers and neurological
disorders.
Repair of an 8-oxo-7,8-dihydroguanine (8oxoG) lesion
within the CAG trinucleotide repeat tract of the huntingtin gene by
BER, is implicated in expansion of the repeat tract leading to
Huntington’s disease (HD). In this work, we employ transient-state
and steady-state kinetic techniques to provide insight into the
molecular mechanisms and substrate specificity of BER enzymes to
better understand the disorders that arise due to incorrect
repair.
Moreover, we center our work on examining kinetics of BER enzymes
on CAG repeat containing DNA to provide insight into the molecular
mechanism of repeat expansion seen in HD. Through examination of
kinetics of removal of an 8oxoG lesion by the DNA glycosylase
oxoguanine glycosylase 1 (OGG1) from CAG repeat and non-repetitive
sequences, and of coordination of OGG1 with APE1, we revealed that
BER is initiated by OGG1 and coordinated with APE1 on CAG repeat
sequences as well as on non-repetitive sequences. We further
examined kinetics of APE1 cleaving DNA on authentic DNA substrates,
and commonly used DNA analogs. Kinetics revealed APE1 incises DNA
at rate ≥ 700 s-1, making APE1 one of the faster BER enzymes. We
observed differences in the rate of APE1 incision on authentic DNA
substrate, compared to commonly used analogs. Finally, we examined
kinetics of pol β incorporating single and multiple nucleotides on
CAG repeat and non-repetitive DNA sequences. While we observed
similar kinetics for pol β single-nucleotide incorporation on CAG
repeat and non-repetitive sequences, we observed difference in
multinucleotide incorporation on CAG repeat versus non-repetitive
sequences. The experiments performed here expand our understanding
of the action of several BER enzymes, and provide further insight
into the molecular mechanism of CAG repeat expansion seen in
HD.
Advisors/Committee Members: Delaney, Sarah (Director), Cane, David (Reader), Basu, Amit (Reader).
Subjects/Keywords: Base Excision Repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schermerhorn, K. (2014). A Kinetic Perspective on DNA Base Excision Repair. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:386264/
Chicago Manual of Style (16th Edition):
Schermerhorn, Kelly. “A Kinetic Perspective on DNA Base Excision Repair.” 2014. Doctoral Dissertation, Brown University. Accessed April 12, 2021.
https://repository.library.brown.edu/studio/item/bdr:386264/.
MLA Handbook (7th Edition):
Schermerhorn, Kelly. “A Kinetic Perspective on DNA Base Excision Repair.” 2014. Web. 12 Apr 2021.
Vancouver:
Schermerhorn K. A Kinetic Perspective on DNA Base Excision Repair. [Internet] [Doctoral dissertation]. Brown University; 2014. [cited 2021 Apr 12].
Available from: https://repository.library.brown.edu/studio/item/bdr:386264/.
Council of Science Editors:
Schermerhorn K. A Kinetic Perspective on DNA Base Excision Repair. [Doctoral Dissertation]. Brown University; 2014. Available from: https://repository.library.brown.edu/studio/item/bdr:386264/
7.
Onken, Andrew Garrett.
Development Of A High Strength Laminate Repair System.
Degree: MS, Chemical Engineering, 2012, University of North Dakota
URL: https://commons.und.edu/theses/1310
► Composite manufacturing often requires repairs at some point during the life of the part. Working with LM Wind Power, the Chemical and Mechanical Engineering…
(more)
▼ Composite manufacturing often requires repairs at some point during the life of the part. Working with LM Wind Power, the Chemical and Mechanical Engineering Departments at the University of North Dakota worked to develop a new laminate
repair system to be used in composite repairs. Both chemical and mechanical test methods were explored to analyze various resins in an attempt to increase the interface toughness between the parent laminate and
repair laminate. A total of six resins from four suppliers were tested. Differential scanning calorimetry and dynamic mechanical rheological testing were performed to analyze the curing kinetics of each resin tested. Static double cantilever beam and tension-tension fatigue tests were performed to measure the mechanical performance of each resin. All specimens were prepared to mimic that of a large-scale wind turbine blade. Each resin tested was compared to the current
repair resin system to determine which choice was best to meet the requirements set for by LM Wind Power for
repair laminate improvement. The results indicated that toughened resin performance is superior to that of the current resin system.
Along with the analysis of new
repair resins, an initiator study was performed. The initiator study was done on the blade resin used for vacuum assisted resin transfer molding (VARTM). Four initiators were tested and compared to the current initiator. Methods included differential scanning calorimetry and rheology. The goal with testing these initiators was to see if changing the initiator would increase the working time while decreasing the overall curing time. To achieve this, the initial viscosity of the resin needed to remain low to ensure a full wet out of the part and once wet out was complete a sharp increase in viscosity would indicate a fast cure. Of the initiators tested, Pulcat from Syrgis Performance Initiators performed better than the others. However, without testing it in production, it is unclear whether or not it is superior to the current initiator MCP-75.
Advisors/Committee Members: Brian M. Tande.
Subjects/Keywords: Composites; Laminates; Repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Onken, A. G. (2012). Development Of A High Strength Laminate Repair System. (Masters Thesis). University of North Dakota. Retrieved from https://commons.und.edu/theses/1310
Chicago Manual of Style (16th Edition):
Onken, Andrew Garrett. “Development Of A High Strength Laminate Repair System.” 2012. Masters Thesis, University of North Dakota. Accessed April 12, 2021.
https://commons.und.edu/theses/1310.
MLA Handbook (7th Edition):
Onken, Andrew Garrett. “Development Of A High Strength Laminate Repair System.” 2012. Web. 12 Apr 2021.
Vancouver:
Onken AG. Development Of A High Strength Laminate Repair System. [Internet] [Masters thesis]. University of North Dakota; 2012. [cited 2021 Apr 12].
Available from: https://commons.und.edu/theses/1310.
Council of Science Editors:
Onken AG. Development Of A High Strength Laminate Repair System. [Masters Thesis]. University of North Dakota; 2012. Available from: https://commons.und.edu/theses/1310
8.
O'NEILL, MAEVE.
Biomechanics of Repair in Invertebrates.
Degree: School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019, Trinity College Dublin
URL: http://hdl.handle.net/2262/85998
► Repair is a ubiquitous process in nature, and it is one of the many features of biological materials that humans are constantly attempting to recreate.…
(more)
▼ Repair is a ubiquitous process in nature, and it is one of the many features of biological materials that humans are constantly attempting to recreate. Though the process of
repair has been studied in mammals, very little work has been done on other organisms, despite mammals representing just a minuscule percentage of global biodiversity. This thesis bridges some of these gaps in the knowledge, focusing of the
repair process in two different organisms, the desert locust (Schistocerca gregaria) and the common limpet (Patella vulgata).
For the locusts a link was drawn between age and
repair capabilities, similar to that observed in mammals, finding that older insects are less capable of
repair. Both young and old insects
repair damage by the deposition of fresh material. Older cuticle was also found to have a decreased fracture toughness. This has implications for energy storage for jumping manoeuvres which was found to involve the deformation of the stiff tibial cuticle. This deformation causes microdamage to the cuticle, in addition to the viscoelastic changes in behaviour, and poses the potential risk of fatigue failure in cuticle. This damage is repaired in a week, similar to the
repair of microcracks in bone. The fracture toughness of the limpet shells was similarly evaluated and found to be much higher than that of its main component, calcium carbonate. Several toughening mechanisms that help to achieve this were identified. The limpets were also found to be similarly susceptible to fatigue failure, though some remodelling process may be occurring. The limpets are also capable to repairing damage to their shells, and like the locusts they achieve this by depositing fresh material, though another unidentified mechanism is at work.
Throughout this thesis comparisons were made to
repair in mammalian bone. Bone has been very thoroughly studied and the mechanisms of
repair are well understood. Several of the effects discussed in this thesis mirror effects observed in bone. Consequently, comparisons to bone are drawn to give greater context and enable discussion about the studies.
Advisors/Committee Members: Taylor, David.
Subjects/Keywords: Repair; Ivertebrate; Biomechanics
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
O'NEILL, M. (2019). Biomechanics of Repair in Invertebrates. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/85998
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
O'NEILL, MAEVE. “Biomechanics of Repair in Invertebrates.” 2019. Thesis, Trinity College Dublin. Accessed April 12, 2021.
http://hdl.handle.net/2262/85998.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
O'NEILL, MAEVE. “Biomechanics of Repair in Invertebrates.” 2019. Web. 12 Apr 2021.
Vancouver:
O'NEILL M. Biomechanics of Repair in Invertebrates. [Internet] [Thesis]. Trinity College Dublin; 2019. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/2262/85998.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
O'NEILL M. Biomechanics of Repair in Invertebrates. [Thesis]. Trinity College Dublin; 2019. Available from: http://hdl.handle.net/2262/85998
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brock University
9.
Page, Melissa Maire.
Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates
.
Degree: Department of Biological Sciences, 2011, Brock University
URL: http://hdl.handle.net/10464/3425
► In animals, both stress resistance and longevity appear to be influenced by the insulin/insulin-like growth factor-l signaling (lIS) pathway, the basic organization of which is…
(more)
▼ In animals, both stress resistance and longevity appear to be influenced by the
insulin/insulin-like growth factor-l signaling (lIS) pathway, the basic organization of
which is highly conserved from invertebrates to vertebrates. Reduced lIS or genetic
disruption of the lIS pathway leads to the activation of forkhead box transcription factors,
which is thought to upregulate the expression of genes involved in enhancing stress
resistance, including perhaps key antioxidant enzymes as well as DNA repair enzymes.
Enhanced antioxidant and DNA repair capacities may underlie the enhanced cellular
stress resistance observed in long-lived animals, however little data is available that
directly supports this idea. I used three. experimental approaches to test the association of
intracellular antioxidant and DNA base excision repair (BER) capacities with stress
resistance and longevity: (1) a comparison of multiple vertebrate endotherm species of
varying body masses and longevities; (2) a comparison of long-lived Snell dwarf mice
and their normallittermates; and (3) a comparison of hypometabolic animals undergoing
hibernation or estivation with their active counterparts. The activities of the five major
intracellular antioxidant enzymes as well as the two rate-limiting enzymes in the BER
pathway, apurininc/apyrimidinic (AP) endonuclease and polymerase ~, were measured.
These measurements were performed in one or more of the following: (1) cultured
dermal fibroblasts; (2) brain tissue; (3) heart tissue; (4) liver tissue. My results indicate
that antioxidant enzymes are not universally upregulated in association with enhanced
stress resistance and longevity. I also did not find that BER enzyme activity was
positively correlated with longevity, in an inter-species context, though there was
evidence for enhanced BER in long-lived Snell dwarf mice. Thus, while there were instances in which enhanced antioxidant and BER enzyme activities were associated with
increased stress resistance and/or longevity, this was not universally the case, indicating
that other mechanisms must be involved. These results suggest the need to re-examine
existing 'oxidative stress' hypotheses of longevity and probe further into the molecular
physiology of longevity to discover its mechanistic basis.
Subjects/Keywords: DNA repair;
Longevity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Page, M. M. (2011). Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates
. (Thesis). Brock University. Retrieved from http://hdl.handle.net/10464/3425
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Page, Melissa Maire. “Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates
.” 2011. Thesis, Brock University. Accessed April 12, 2021.
http://hdl.handle.net/10464/3425.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Page, Melissa Maire. “Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates
.” 2011. Web. 12 Apr 2021.
Vancouver:
Page MM. Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates
. [Internet] [Thesis]. Brock University; 2011. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/10464/3425.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Page MM. Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates
. [Thesis]. Brock University; 2011. Available from: http://hdl.handle.net/10464/3425
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin
10.
Fu, Qiong, Ph. D.
Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2.
Degree: PhD, Microbiology, 2014, University of Texas – Austin
URL: http://hdl.handle.net/2152/46516
► In response to DNA damage, many repair and signaling molecules mobilize rapidly to the sites of DNA double-strand breaks (DSBs). This network of immediate responses…
(more)
▼ In response to DNA damage, many
repair and signaling molecules mobilize rapidly to the sites of DNA double-strand breaks (DSBs). This network of immediate responses is regulated at the level of post-translational modifications to coordinate DNA
repair and checkpoint signaling. Here we investigate the DNA damage-induced oligomeric transitions of the Sae2 protein, an important enzyme in the initiation of DSB
repair. Sae2 is a target of multiple phosphorylation events, which we identify and characterize in vivo in budding yeast. Both cell cycle-dependent and DNA damage-induced phosphorylation of Sae2 are important for the cell survival after DNA damage, and the cell cycle-regulated modifications are required to prime the damage-dependent events. We find that Sae2 exists in the form of inactive oligomers that are transiently released into smaller active units by these series of phosphorylation events. DNA damage also triggers removal of Sae2 through autophagy and proteasomal degradation, ensuring that active Sae2 is present only transiently in cells. This analysis provides evidence for a novel type of protein regulation where the activity of an enzyme is controlled dynamically by post-translational modifications that regulate its solubility and oligomeric state. Budding yeast Ess1 is a phosphorylation-specific prolyl isomerase. Its human homolog Pin1 is found to isomerize CtIP, the human functional ortholog of Sae2, and promote the proteasomal degradation of CtIP. However, I could neither detect any interaction between Ess1 and Sae2, nor observe any change in Sae2 protein level while overexpressing wild-type or mutant Ess1, suggesting Ess1 does not act on Sae2, like Pin1 does on CtIP. The increased DNA damage sensitivity of Ess1 mutants indicates that Ess1 is involved in DNA
repair, but not related to Sae2. Since Ess1 plays an important role in transcription termination together with a RNA 3’ end processing factor Pcf11, I overexpressed wild-type Pcf11 and found it significantly increased the DNA damage resistance of either wild-type or H164R mutant Ess1 cells, and also the sae2Δ cells. These results imply that Ess1, Pcf11 and Sae2 might contribute to DNA damage
repair through transcription termination, which links transcription termination and DNA damage
repair together.
Advisors/Committee Members: Paull, Tanya T. (advisor), Iyer, Vishwanath R (committee member), Jayaram, Makkuni (committee member), Johnson, Arlen W (committee member), Zhang, Yan (committee member).
Subjects/Keywords: DNA repair; Sae2
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fu, Qiong, P. D. (2014). Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/46516
Chicago Manual of Style (16th Edition):
Fu, Qiong, Ph D. “Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed April 12, 2021.
http://hdl.handle.net/2152/46516.
MLA Handbook (7th Edition):
Fu, Qiong, Ph D. “Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2.” 2014. Web. 12 Apr 2021.
Vancouver:
Fu, Qiong PD. Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/2152/46516.
Council of Science Editors:
Fu, Qiong PD. Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/46516

University of Toronto
11.
Campbell, Brittany B.
Studies on DNA Replication Repair and Cancer: Insights from Biallelic Mismatch Repair Deficiency Syndrome.
Degree: PhD, 2018, University of Toronto
URL: http://hdl.handle.net/1807/89691
► Biallelic Mismatch Repair Deficiency Syndrome (bMMRD) is an aggressive childhood inherited cancer predisposition syndrome. Individuals harboring biallelic germline mutations in the mismatch repair genes (MSH2,…
(more)
▼ Biallelic Mismatch
Repair Deficiency Syndrome (bMMRD) is an aggressive childhood inherited cancer predisposition syndrome. Individuals harboring biallelic germline mutations in the mismatch
repair genes (MSH2, MSH6, MLH1, or PMS2) develop a myriad of cancers in all tissues; predominantly brain tumors, hematological malignancies and gastrointestinal cancers. Due to the rarity of the syndrome, the origin and progression of bMMRD cancers is not yet clearly understood. The focus of this thesis work is to elucidate the clinical and biological aspects of bMMRD cancers and to apply these findings across other tumors with replication
repair deficiency. Chapter 1 delivers an overview of various aspects of DNA replication
repair and their implications to cancer development and therapies. Chapter 2 describes recent advances in our understanding of both clinical and biological aspects of bMMRD, including prevalence of the syndrome, techniques for diagnosis, tumor spectrum and onset, and surveillance recommendations. Chapter 3 focuses on genomic profiling of tumors arising from bMMRD, including the discovery of the first pediatric ultrahypermutant tumors, secondary somatic driving mutations unique to bMMRD tumors, and the implications of the genomic findings as they pertain to tumor onset and progression. Chapter 4 expands the discovery of hypermutant tumors beyond the syndrome to a wide variety of pediatric and adult tumor types, thereby revealing the greater role that replication
repair deficiency plays in tumor onset and progression across cancers in general. In Chapter 5, the hypermutant phenotype in bMMRD tumors is used to justify the administration of a novel immune-based therapy. The aim of this thesis is to utilize bMMRD as a model system for replication
repair deficiency as it pertains to cancer in general, while also applying the findings to improve patient care.
Advisors/Committee Members: Tabori, Uri, Medical Science.
Subjects/Keywords: Cancer; CMMRD; DNA repair; Glioblastoma Multiforme; Mismatch repair; Replication repair; 0564
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Campbell, B. B. (2018). Studies on DNA Replication Repair and Cancer: Insights from Biallelic Mismatch Repair Deficiency Syndrome. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89691
Chicago Manual of Style (16th Edition):
Campbell, Brittany B. “Studies on DNA Replication Repair and Cancer: Insights from Biallelic Mismatch Repair Deficiency Syndrome.” 2018. Doctoral Dissertation, University of Toronto. Accessed April 12, 2021.
http://hdl.handle.net/1807/89691.
MLA Handbook (7th Edition):
Campbell, Brittany B. “Studies on DNA Replication Repair and Cancer: Insights from Biallelic Mismatch Repair Deficiency Syndrome.” 2018. Web. 12 Apr 2021.
Vancouver:
Campbell BB. Studies on DNA Replication Repair and Cancer: Insights from Biallelic Mismatch Repair Deficiency Syndrome. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1807/89691.
Council of Science Editors:
Campbell BB. Studies on DNA Replication Repair and Cancer: Insights from Biallelic Mismatch Repair Deficiency Syndrome. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89691

Louisiana State University
12.
Li, Mingyang.
DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast.
Degree: PhD, Laboratory and Basic Science Research, 2017, Louisiana State University
URL: https://digitalcommons.lsu.edu/gradschool_dissertations/4186
► In eukaryotes, DNA repair mechanisms detect and repair damaged DNA. DNA damage is primarily caused by a variety of exogenous and endogenous sources. Several…
(more)
▼ In eukaryotes, DNA repair mechanisms detect and repair damaged DNA. DNA damage is primarily caused by a variety of exogenous and endogenous sources. Several types of damage to DNA are repaired by different kinds of DNA repair pathways. This dissertation focused on repair of N-methylpurines (NMPs) and double-strand breaks (DSBs) in human fibroblasts.
NMPs, including N7-methylguanine (7MeG) and N3-methyladenine (3MeA), can be induced by environmental methylating agents (e.g. the soil fumigant methyl bromide), chemotherapeutics (e.g. nitrogen mustards), and natural cellular methyl donors like S-adenosylmethionine. In human cells, NMPs are repaired by the multi-step base excision repair pathway initiated by human alkyladenine glycosylase (hAAG). Repair of NMPs has been shown to be affected by DNA sequence contexts. However, the nature of the sequence contexts has been poorly understood. We developed a sensitive method, LAF-Seq (Lesion-Adjoining Fragment Sequencing), which allows nucleotide-resolution digital mapping of DNA damage and repair in multiple genomic fragments of interest in human cells. We also developed a strategy that allows accurate measurement of the excision kinetics of NMP bases in vitro. We demonstrate that 3MeAs are induced to a much lower level by the S<em>N</em>2 methylating agent dimethyl sulfate (DMS) and repaired much faster than 7MeGs in human fibroblasts. Induction of 7MeGs by DMS is affected by nearest-neighbor nucleotides, being enhanced at sites neighbored by a G or T on the 3’ side, but impaired at sites neighbored by a G on the 5’ side. Repair of 7MeGs is also affected by nearest-neighbor nucleotides, being slow if the lesions are between purines, especially Gs, and fast if the lesions are between pyrimidines, especially Ts. Excision of 7MeG bases from the DNA backbone by hAAG in vitro is similarly affected by nearest-neighbor nucleotides, suggesting that the effect of nearest-neighbor nucleotides on repair of 7MeGs in the cells is primarily achieved by modulating the initial step of the base excision repair process.
DSBs can be induced by hydrogen peroxide (H2O2), endonuclease I-PpoI and ionizing radiation. Senataxin is a putative RNA/DNA helicase. We demonstrate that senataxin facilitates repair of DSBs and modulates the activation of DNA damage response pathway of ATM-Chk2 and ATR-Chk1 upon DSB damage.
Subjects/Keywords: DNA repair; DNA damage; Base excision repair; Double-strand break repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Li, M. (2017). DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast. (Doctoral Dissertation). Louisiana State University. Retrieved from https://digitalcommons.lsu.edu/gradschool_dissertations/4186
Chicago Manual of Style (16th Edition):
Li, Mingyang. “DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast.” 2017. Doctoral Dissertation, Louisiana State University. Accessed April 12, 2021.
https://digitalcommons.lsu.edu/gradschool_dissertations/4186.
MLA Handbook (7th Edition):
Li, Mingyang. “DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast.” 2017. Web. 12 Apr 2021.
Vancouver:
Li M. DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast. [Internet] [Doctoral dissertation]. Louisiana State University; 2017. [cited 2021 Apr 12].
Available from: https://digitalcommons.lsu.edu/gradschool_dissertations/4186.
Council of Science Editors:
Li M. DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast. [Doctoral Dissertation]. Louisiana State University; 2017. Available from: https://digitalcommons.lsu.edu/gradschool_dissertations/4186

Louisiana State University
13.
Tatum, Danielle Marie.
Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast.
Degree: PhD, Medicine and Health Sciences, 2011, Louisiana State University
URL: etd-06202011-122520
;
https://digitalcommons.lsu.edu/gradschool_dissertations/57
► ABSTRACT Nucleotide excision repair (NER) is a highly conserved DNA repair mechanism which deals with a wide variety of bulky, helix-distorting lesions, such as UV-induced…
(more)
▼ ABSTRACT Nucleotide excision repair (NER) is a highly conserved DNA repair mechanism which deals with a wide variety of bulky, helix-distorting lesions, such as UV-induced cyclobutane pyrimidine dimers (CPDs). NER is traditionally grouped into two pathways: global genomic repair (GGR), which is operative throughout the genome, and transcription coupled repair (TCR), which is dedicated to rapid repair of the transcribed strand of actively transcribed genes. Though most of the core NER proteins are known, the exact biochemical mechanism of eukaryotic NER remains elusive. This dissertation focused on identifying novel core and accessory factors which function in NER. In the budding yeast Saccharomyces cerevisiae, GGR has previously been shown to be dependent on Rad7 and Rad16. We revealed Elc1, the yeast homolog of human elongin C, as a novel GGR-specific factor. Elc1 is required for GGR, but has no role in TCR. The precise role of Elc1 in GGR remains unknown. Dot1 is a histone methyltransferase whose sole substrate is histone H3 lysine 79 (H3K79). We identified Dot1 as another GGR-specific factor, as deletion of Dot1 or mutation of H3K79 abolishes GGR, but has no effect on TCR. H3K79 can accept up to 3 methyl groups, but Dot1 can only add one by itself. The PAF transcription elongation complex, through facilitating histone modifications, is partially required for dimethylation and fully required for trimethylation of H3K79 by Dot1. We demonstrated that through facilitating these histone modifications, PAF is partially required for GGR. TCR is believed to be triggered by a stalled elongating RNA polymerase II (Pol II) complex. Rad26, the homolog of the human CSB gene, and Rpb9, a nonessential subunit of Pol II, play important roles in TCR. We identified a dual role for PAF in TCR. In the presence of Rad26, PAF plays a positive role, facilitating TCR. In the absence of Rad26, PAF functions as a suppressor of TCR. PAF appears to be a part of a “megasuppressor” complex which includes Rpb4 and the Spt4/Spt5 complex, which also suppress Rad26-independent TCR. The interactions among Pol II, Rad26 and the various TCR suppressors remain to be elucidated.
Subjects/Keywords: nucleotide excision repair; transcription coupled repair; global genomic repair; cyclobutane pyrimidine dimers; RNA polymerase II
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tatum, D. M. (2011). Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57
Chicago Manual of Style (16th Edition):
Tatum, Danielle Marie. “Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast.” 2011. Doctoral Dissertation, Louisiana State University. Accessed April 12, 2021.
etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57.
MLA Handbook (7th Edition):
Tatum, Danielle Marie. “Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast.” 2011. Web. 12 Apr 2021.
Vancouver:
Tatum DM. Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast. [Internet] [Doctoral dissertation]. Louisiana State University; 2011. [cited 2021 Apr 12].
Available from: etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57.
Council of Science Editors:
Tatum DM. Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast. [Doctoral Dissertation]. Louisiana State University; 2011. Available from: etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57
14.
Mayuga, Gian Paolo Topico.
Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールド デノ ジコ シュウフク アヤマリ テイセイ レッカ ケンチ オ クミアワセタ コウシンライ メモリ アーキテクチャ.
Degree: 博士(工学), 2016, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学
URL: http://hdl.handle.net/10061/11007
Subjects/Keywords: memory repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mayuga, G. P. T. (2016). Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールド デノ ジコ シュウフク アヤマリ テイセイ レッカ ケンチ オ クミアワセタ コウシンライ メモリ アーキテクチャ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/11007
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mayuga, Gian Paolo Topico. “Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールド デノ ジコ シュウフク アヤマリ テイセイ レッカ ケンチ オ クミアワセタ コウシンライ メモリ アーキテクチャ.” 2016. Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed April 12, 2021.
http://hdl.handle.net/10061/11007.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mayuga, Gian Paolo Topico. “Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールド デノ ジコ シュウフク アヤマリ テイセイ レッカ ケンチ オ クミアワセタ コウシンライ メモリ アーキテクチャ.” 2016. Web. 12 Apr 2021.
Vancouver:
Mayuga GPT. Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールド デノ ジコ シュウフク アヤマリ テイセイ レッカ ケンチ オ クミアワセタ コウシンライ メモリ アーキテクチャ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; 2016. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/10061/11007.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mayuga GPT. Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールド デノ ジコ シュウフク アヤマリ テイセイ レッカ ケンチ オ クミアワセタ コウシンライ メモリ アーキテクチャ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; 2016. Available from: http://hdl.handle.net/10061/11007
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester
15.
DeRan, Michael.
The Role of NPAT in S-Phase-Dependent Histone Gene
Transcription and DNA Double-Strand Break Repair.
Degree: PhD, 2011, University of Rochester
URL: http://hdl.handle.net/1802/14593
► In eukaryotic cells, DNA is packaged into chromatin by the histone proteins. The bulk of histone synthesis occurs in S-phase in order to package the…
(more)
▼ In eukaryotic cells, DNA is packaged into chromatin
by the histone proteins. The bulk of histone synthesis occurs in
S-phase in order to package the nascent DNA. Thus, the core
histones, H2A, H2B, H3, and H4 and the linker histone H1 are termed
the replication-dependent histones. The expression of the
replication-dependent histones is coordinately controlled and
tightly coupled to DNA replication in S-phase. It is clear that
coordination and coupling are critical. Perturbations to
coordination result in chromosome loss and uncoupling of histone
gene expression from DNA replication lead to developmental arrest.
The mechanisms through which coordination is achieved are poorly
understood. It has been shown previously that the cyclin E/Cdk2
substrate NPAT plays an essential role in activating transcription
of all of the replication-dependent histone genes at the G1-S
transition. Here we show that NPAT regulates the transcription of
the replication-dependent histone genes through a novel amino acid
motif that is functionally conserved in E2F and E1A proteins.
Through this motif, NPAT interacts with members of the Tip60
histone acetyltransferase complex. Two members of this complex,
TRRAP and Tip60, are recruited to replication-dependent histone
gene promoters at the G1-S transition, in an NPAT-dependent manner.
Concurrent with the recruitment of TRRAP and Tip60 to these
promoters, levels of histone H4 acetylation are increased.
Additionally, the suppression of TRRAP or Tip60 by RNAi, inhibits
the activation of these promoters. These data show that NPAT
regulates the transcription of the replication-dependent histone
genes through the recruitment of the Tip60 histone
acetyltransferase complex to these promoters at the G1-S
transition, thus inducing histone H4 acetylation and gene
expression.
Eukaryotes have evolved a complex DNA damage response
that integrates mechanisms of DNA surveillance and repair with the
induction of proliferative arrest via cell cycle checkpoints.
Defects in the detection and repair of DNA lesions have been
implicated in a number of human malignancies. DNA double-strand
breaks, which are a severe threat to genomic stability, are
primarily repaired by either homology-directed recombination (HR)
or non-homologous end joining (NHEJ) in eukaryotic cells. In
addition to the role of NPAT in replication-dependent histone gene
expression, several pieces of evidence indicate that NPAT plays a
critical role in DNA double-strand break repair. We have observed
that NPAT interacts with a number of proteins involved in DNA
double-strand break repair. Notably, NPAT-deficient cells exhibit
delayed kinetics of DNA repair and prolonged accumulation of
phosphorylated histone H2AX, a marker for damaged DNA. Furthermore,
suppression of NPAT expression by NPAT-specific shRNA leads to
decreased repair by HR and NHEJ, as well as decreased accumulation
of ubiquitinated proteins and several repair factors at the sites
of DNA lesions. These results demonstrate a novel function of NPAT
in DNA double-strand break repair in…
Subjects/Keywords: Histone; Transcription; DNA Repair; NPAT
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
DeRan, M. (2011). The Role of NPAT in S-Phase-Dependent Histone Gene
Transcription and DNA Double-Strand Break Repair. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/14593
Chicago Manual of Style (16th Edition):
DeRan, Michael. “The Role of NPAT in S-Phase-Dependent Histone Gene
Transcription and DNA Double-Strand Break Repair.” 2011. Doctoral Dissertation, University of Rochester. Accessed April 12, 2021.
http://hdl.handle.net/1802/14593.
MLA Handbook (7th Edition):
DeRan, Michael. “The Role of NPAT in S-Phase-Dependent Histone Gene
Transcription and DNA Double-Strand Break Repair.” 2011. Web. 12 Apr 2021.
Vancouver:
DeRan M. The Role of NPAT in S-Phase-Dependent Histone Gene
Transcription and DNA Double-Strand Break Repair. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1802/14593.
Council of Science Editors:
DeRan M. The Role of NPAT in S-Phase-Dependent Histone Gene
Transcription and DNA Double-Strand Break Repair. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/14593

Mississippi State University
16.
McLaurin, David Owen.
ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR.
Degree: PhD, Aerospace Engineering, 2010, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/
;
► Computational analysis and design has become a fundamental part of product research, development, and manufacture in aerospace, automotive, and other industries. In general the success…
(more)
▼ Computational analysis and design has become a fundamental part of product research, development, and manufacture in aerospace, automotive, and other industries. In general the success of the specific application depends heavily on the accuracy and consistency of the computational model used. The aim of this work is to reduce the time needed to prepare geometry for mesh generation. This will be accomplished by developing tools that semi-automatically
repair discrete data. Providing a level of automation to the process of repairing large, complex problems in discrete data will significantly accelerate the grid generation process. The developed algorithms are meant to offer semi-automated solutions to complicated geometrical problemsspecifically discrete mesh intersections and isolated boundaries.
The intersection-
repair strategy presented here focuses on repairing the intersection in-place as opposed to re-discretizing the intersecting geometries. Combining robust, efficient methods of detecting intersections and then repairing intersecting geometries in-place produces a significant improvement over techniques used in current literature. The result of this intersection process is a non-manifold, non-intersecting geometry that is free of duplicate and degenerate geometry. Results are presented showing the accuracy and consistency of the intersection
repair tool.
Isolated boundaries are a type of gap that current research does not address directly. They are defined by discrete boundary edges that are unable to be paired with nearby discrete boundary edges in order to fill the existing gap. In this research the method of
repair seeks to fill the gap by extruding the isolated boundary along a defined vector so that it is topologically adjacent to a nearby surface. The outcome of the
repair process is that the isolated boundaries no longer exist because the gap has been filled. Results are presented showing the precision of the edge projection and the advantage of edge splitting in the
repair of isolated boundaries.
Advisors/Committee Members: David Marucm (chair), Pasquale Cinnella (chair), Eric Blades (committee member), Mike Remotigue (committee member), David Thompson (committee member).
Subjects/Keywords: mesh repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McLaurin, D. O. (2010). ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;
Chicago Manual of Style (16th Edition):
McLaurin, David Owen. “ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR.” 2010. Doctoral Dissertation, Mississippi State University. Accessed April 12, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;.
MLA Handbook (7th Edition):
McLaurin, David Owen. “ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR.” 2010. Web. 12 Apr 2021.
Vancouver:
McLaurin DO. ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR. [Internet] [Doctoral dissertation]. Mississippi State University; 2010. [cited 2021 Apr 12].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;.
Council of Science Editors:
McLaurin DO. ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR. [Doctoral Dissertation]. Mississippi State University; 2010. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;

University of Alberta
17.
Leung, Charles.
Molecular basis of TopBP1 BRCT domain interactions in the
DNA damage response.
Degree: PhD, Department of Biochemistry, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/jw827c22z
► Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication…
(more)
▼ Topoisomerase II-beta binding protein 1 (TopBP1) is a
critical regulatory protein that integrates diverse signals in the
DNA damage response. In response to DNA replication stress, TopBP1
participates in a series of protein interactions to collectively
activate the key Ser/Thr kinase, Ataxia telangiectasia and Rad3
related (ATR), and control the DNA replication checkpoint. These
phosphorylation-dependent interactions are mediated by the numerous
conserved BRCT domains within TopBP1. Our studies utilize X-ray
crystallography in combination with other biochemical and
biophysical techniques to elucidate the molecular basis underlying
various TopBP1 BRCT-mediated interactions in DNA damage response
signalling. Contrary to previous studies suggesting that the single
BRCT6 domain of TopBP1 recognizes a phospho-peptide of the
transcription factor, E2F1, and binds to poly(ADP-ribose) chains,
the crystal structure of BRCT6 provides evidence that both the
phospho-peptide binding pocket and PAR-binding motif are
non-functional. Our studies of distinct phospho-peptide
interactions involving the tandem BRCT7/8 and BRCT4/5 repeats of
TopBP1 shed light on critical interactions required for activation
of ATR and the DNA replication checkpoint. In addition, the mode of
phospho-peptide recognition presented by these BRCT repeats uncover
new and exciting perspectives in BRCT domain function that were
previously unknown. Analysis of the structures of TopBP1 BRCT7/8
and in complex with a BACH1 phospho-peptide provides the first
demonstration of pThr specificity and an uncharacteristic
plasticity at the BRCT domain interface for canonical tandem BRCT
domains. Our structural investigations of interactions between
TopBP1 BRCT4/5 and a MDC1 phospho-peptide reveal a novel tandem
BRCT domain packing arrangement, as well as an unexpected
dimerization of two BRCT4/5 domains needed to stabilize
interactions with a single phospho-peptide. Taken together, our
studies of TopBP1 BRCT domain interactions provide molecular
insights into crucial protein interactions involved in DNA
replication checkpoint signalling and also highlight the
extraordinary functional diversity of BRCT domains.
Subjects/Keywords: DNA repair; X-ray crystallography
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Leung, C. (2011). Molecular basis of TopBP1 BRCT domain interactions in the
DNA damage response. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/jw827c22z
Chicago Manual of Style (16th Edition):
Leung, Charles. “Molecular basis of TopBP1 BRCT domain interactions in the
DNA damage response.” 2011. Doctoral Dissertation, University of Alberta. Accessed April 12, 2021.
https://era.library.ualberta.ca/files/jw827c22z.
MLA Handbook (7th Edition):
Leung, Charles. “Molecular basis of TopBP1 BRCT domain interactions in the
DNA damage response.” 2011. Web. 12 Apr 2021.
Vancouver:
Leung C. Molecular basis of TopBP1 BRCT domain interactions in the
DNA damage response. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Apr 12].
Available from: https://era.library.ualberta.ca/files/jw827c22z.
Council of Science Editors:
Leung C. Molecular basis of TopBP1 BRCT domain interactions in the
DNA damage response. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/jw827c22z
18.
Jarvis,Kimberly D.
An Exploration of a Culture of Reintegration with Women Who
Have Experienced Obstetrical Fistula Repair in Northern Ghana, West
Africa.
Degree: PhD, Faculty of Nursing, 2016, University of Alberta
URL: https://era.library.ualberta.ca/files/ct435gd21c
► More than two million women in Asia and sub-Saharan Africa live with untreated obstetric fistula (OF). Factors contributing to and affecting the care of OF…
(more)
▼ More than two million women in Asia and sub-Saharan
Africa live with untreated obstetric fistula (OF). Factors
contributing to and affecting the care of OF are embedded in the
social determinants of health. A three-pronged approach to OF care
has been suggested, including awareness, treatment, and social
reintegration; however, women’s health organizations have argued
that social reintegration is the most important aspect of care next
to the surgery itself. The aim of this study was to explore a
culture of reintegration for women who experience an OF repair in
northern Ghana. A critical ethnography was employed, using a health
equity/social justice lens to discern the meaning and point of view
of participants about a culture of reintegration post-OF.
Ninety-nine participants were recruited from 24 rural communities
in northern Ghana using convenience, purposive and snowball
sampling. Study participants included: • Women who had experienced
an OF repair a minimum of three months prior to being interviewed.
• Family members of women who had experienced an OF repair and were
involved in their care pre- and post-OF repair, or post-OF repair
only. Only those identified as family members of women interviewed
were considered. • Health-care providers (HCPs) who cared for women
who experienced an OF repair (i.e. nurses, doctors, traditional
birth attendants, traditional healers). • Community stakeholders,
those in leadership positions, or who provided service to the
community, and were involved in OF care at the community, regional
or national level (i.e. government officials, nongovernmental
organizations, religious leaders, women leaders). Observation,
field notes, personal reflections, semi-structured interviews, and
the assessment of relevant public policy documents were methods
utilized. Data was analysed according to Hammersley and Atkinson’s
(2007) approach to ethnographic analysis. Nvivo 10.0 software was
used for data management. Ethics approval was received from the
Human Research Ethics Review Board at the University of Alberta,
Canada and at the Navrongo Health Research Center, Institutional
Review Board, Ghana. Findings suggest that reintegration does not
occur in isolation of the other two components of care; awareness
and treatment. Although most families are excited to have their
family member return home post-OF, women, families, and communities
do express feelings of uncertainty. Women, their families, HCPs,
and community stakeholders identify that OF health teaching, skills
training, community follow-up, community awareness, family support,
and existing health policies are important factors in the success
of reintegration. Despite this fact, participants describe the
economic, societal, systemic and cultural constraints to a woman’s
ability to reintegrate, and offer solutions for change.
Additionally, family members describe the impact OF had on them,
drawing attention to the need for formal care-giving supports in
light of the changing role of the family in Ghanaian society.
Research findings provide…
Subjects/Keywords: Obstetrical Fistula Repair; Ghana; Reintegration
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
D, J. (2016). An Exploration of a Culture of Reintegration with Women Who
Have Experienced Obstetrical Fistula Repair in Northern Ghana, West
Africa. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/ct435gd21c
Chicago Manual of Style (16th Edition):
D, Jarvis,Kimberly. “An Exploration of a Culture of Reintegration with Women Who
Have Experienced Obstetrical Fistula Repair in Northern Ghana, West
Africa.” 2016. Doctoral Dissertation, University of Alberta. Accessed April 12, 2021.
https://era.library.ualberta.ca/files/ct435gd21c.
MLA Handbook (7th Edition):
D, Jarvis,Kimberly. “An Exploration of a Culture of Reintegration with Women Who
Have Experienced Obstetrical Fistula Repair in Northern Ghana, West
Africa.” 2016. Web. 12 Apr 2021.
Vancouver:
D J. An Exploration of a Culture of Reintegration with Women Who
Have Experienced Obstetrical Fistula Repair in Northern Ghana, West
Africa. [Internet] [Doctoral dissertation]. University of Alberta; 2016. [cited 2021 Apr 12].
Available from: https://era.library.ualberta.ca/files/ct435gd21c.
Council of Science Editors:
D J. An Exploration of a Culture of Reintegration with Women Who
Have Experienced Obstetrical Fistula Repair in Northern Ghana, West
Africa. [Doctoral Dissertation]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/ct435gd21c

Oregon State University
19.
Smith-Roe, Stephanie L.
DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse.
Degree: PhD, Toxicology, 2006, Oregon State University
URL: http://hdl.handle.net/1957/29017
Subjects/Keywords: DNA repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Smith-Roe, S. L. (2006). DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/29017
Chicago Manual of Style (16th Edition):
Smith-Roe, Stephanie L. “DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse.” 2006. Doctoral Dissertation, Oregon State University. Accessed April 12, 2021.
http://hdl.handle.net/1957/29017.
MLA Handbook (7th Edition):
Smith-Roe, Stephanie L. “DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse.” 2006. Web. 12 Apr 2021.
Vancouver:
Smith-Roe SL. DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse. [Internet] [Doctoral dissertation]. Oregon State University; 2006. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1957/29017.
Council of Science Editors:
Smith-Roe SL. DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse. [Doctoral Dissertation]. Oregon State University; 2006. Available from: http://hdl.handle.net/1957/29017
20.
Shamsuddin , Sharifah Hamimah.
Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam.
Degree: Fakulti Kejuruteraan Awam dan Alam Sekitar, 2011, Universiti Tun Hussein Onn Malaysia
URL: http://eprints.uthm.edu.my/id/eprint/1645/
► Penyelenggaraan adalah aktiviti yang dilakukan secara berterusan bagi memastikan fungsi bangunan dapat dilaksanakan sebagaimana fungsinya secara normal. Penyelenggaraan bangunan sekolah adalah aktiviti rutin yang harus…
(more)
▼ Penyelenggaraan adalah aktiviti yang dilakukan secara berterusan bagi memastikan fungsi bangunan dapat dilaksanakan sebagaimana fungsinya secara normal. Penyelenggaraan bangunan sekolah adalah aktiviti rutin yang harus dijalankan memandangkan sekolah adalah lokasi pertama dalam pengembangan minda kanak-kanak. Namun begitu, kajian literatur menunjukkan terdapat beberapa masalah dalam pengurusan penyelenggaraan yang lazimnya diselia oleh ahli jawatankuasa penyelenggaraan sekolah. Antaranya ialah kegagalan mereka mematuhi Pekeliling Am Bil.2 Tahun 1995 dalam proses permohonan penyelenggaraan. Disebabkan permasalahan tersebut, tesis ini diwujudkan bagi membantu mereka dalam menyelesaikan sebahagian masalah yang dihadapi dengan cara membangunkan satu aplikasi permohonan penyelenggaraan sekolah berkomputer. Pembangunan aplikasi adalah menggunakan Microsoft Access. Aplikasi pertama yang dibangunkan adalah CoRTMaS di mana ia hanya tertumpu kepada penyelenggaraan bumbung dan tandas berdasarkan kepada kajian literatur yang mengatakan 2 komponen ini paling kerap mengalami kerosakan. Hasil soal selidik diuji menggunakan SPSS dan mendapati kadar ketepatan hasil kajian adalah α = 0.893. Walaupun hasil kajian CoRTMaS amat memuaskan, aplikasi SiPBaS dibangunkan bagi menambah baik fungsi aplikasi dalam CoRTMaS. Kesimpulannya, pembangunan aplikasi dapat menyumbang kepada kelancaran proses permohonan penyelenggaraan sekolah namun terdapat beberapa cadangan lanjutan yang dicadangkan bagi memantapkan aplikasi SiPBaS iaitu menjadikan aplikasi ini berfungsi secara atas talian, mewujudkan ruangan bagi memuat turun gambar kerosakan serta mewujudkan kod keselamatan untuk kontraktor terlibat.
Subjects/Keywords: TH3301-3411 Maintenance and repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Shamsuddin , S. H. (2011). Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam. (Masters Thesis). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/id/eprint/1645/
Chicago Manual of Style (16th Edition):
Shamsuddin , Sharifah Hamimah. “Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam.” 2011. Masters Thesis, Universiti Tun Hussein Onn Malaysia. Accessed April 12, 2021.
http://eprints.uthm.edu.my/id/eprint/1645/.
MLA Handbook (7th Edition):
Shamsuddin , Sharifah Hamimah. “Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam.” 2011. Web. 12 Apr 2021.
Vancouver:
Shamsuddin SH. Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam. [Internet] [Masters thesis]. Universiti Tun Hussein Onn Malaysia; 2011. [cited 2021 Apr 12].
Available from: http://eprints.uthm.edu.my/id/eprint/1645/.
Council of Science Editors:
Shamsuddin SH. Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam. [Masters Thesis]. Universiti Tun Hussein Onn Malaysia; 2011. Available from: http://eprints.uthm.edu.my/id/eprint/1645/
21.
Abdul Rahman, Mohammad Ashraf.
Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia.
Degree: phd, Fakulti Kejuruteraan Awam dan Alam Sekitar, 2013, Universiti Tun Hussein Onn Malaysia
URL: http://eprints.uthm.edu.my/id/eprint/4336/
► Pendekatan penyenggaraan seringkali dianggap sebagai aktiviti yang remeh sehinggakan dalam praktis semasa, pendekatan ini tidak dapat menarik perhatian kebanyakkan golongan berpengetahuan dan berkemahiran. Senario ini…
(more)
▼ Pendekatan penyenggaraan seringkali dianggap sebagai aktiviti yang remeh
sehinggakan dalam praktis semasa, pendekatan ini tidak dapat menarik perhatian
kebanyakkan golongan berpengetahuan dan berkemahiran. Senario ini memberikan
justifikasi awal mengenai budaya semasa penyenggaraan yang tidak lagi diterapkan
secara cekap dan berkesan. Sehubungan dengan itu matlamat kajian ini adalah untuk
meneroka perspektif semasa amalan pengurusan warisan dalam industri pengekalan
dan pemuliharaan bangunan warisan di Malaysia, mengenalpasti faktor yang
mempengaruhi amalan semasa dan membentuk faktor kejayaan utama amalan terbaik
pengurusan penyenggaraan bangunan warisan di Malaysia. Dalam mencapai
matlamat tersebut, satu model penilaian amalan terbaik pengurusan penyenggaraan
bangunan warisan telah dibangunkan menggunakan kaedah Analytic Hierarchy
Process (AHP) berpandukan kepada elemen kriteria amalan terbaik. Model penilaian
ini telah diuji di enam buah organisasi pengurusan penyenggaraan bangunan warisan.
Hasil penemuan mendapati bahawa indikasi amalan semasa pengurusan
penyenggaraan bangunan warisan di Malaysia telah dikategorikan sebagai lemah
(59.05%). Kajian seterusnya adalah untuk mengenalpasti masalah yang menyumbang
kepada kelemahan amalan semasa di mana maklumbalas dari 63 responden yang
terdiri daripada ahli akademik dan profesional industri mendapati bahawa masalah
kewangan, kekurangan institusi serta kemudahan latihan, masalah alat ganti dan
sikap manusia sebagai faktor yang amat signifikan. Sebagai refleks kepada masalah
yang telah dikenalpasti, model kejayaan utama amalan terbaik pengurusan
penyenggaraan bangunan warisan telah direkabentuk bagi proses menambahbaik
praktis amalan semasa. Kesimpulannya, model kejayaan utama yang dibentuk
berpotensi membantu ke arah mengubah amalan semasa yang lemah kepada amalan
yang lebih baik dan berkesan di masa hadapan.
Subjects/Keywords: TH3301-3411 Maintenance and repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Abdul Rahman, M. A. (2013). Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia. (Doctoral Dissertation). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/id/eprint/4336/
Chicago Manual of Style (16th Edition):
Abdul Rahman, Mohammad Ashraf. “Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia.” 2013. Doctoral Dissertation, Universiti Tun Hussein Onn Malaysia. Accessed April 12, 2021.
http://eprints.uthm.edu.my/id/eprint/4336/.
MLA Handbook (7th Edition):
Abdul Rahman, Mohammad Ashraf. “Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia.” 2013. Web. 12 Apr 2021.
Vancouver:
Abdul Rahman MA. Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia. [Internet] [Doctoral dissertation]. Universiti Tun Hussein Onn Malaysia; 2013. [cited 2021 Apr 12].
Available from: http://eprints.uthm.edu.my/id/eprint/4336/.
Council of Science Editors:
Abdul Rahman MA. Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia. [Doctoral Dissertation]. Universiti Tun Hussein Onn Malaysia; 2013. Available from: http://eprints.uthm.edu.my/id/eprint/4336/
22.
Ismail, Zul-Atfi.
DMOSYS: defect monitoring system for building maintenance at polytechnic.
Degree: Fakulti Pengurusan Teknologi dan Perniagaan, 2013, Universiti Tun Hussein Onn Malaysia
URL: http://eprints.uthm.edu.my/id/eprint/5456/
► Maintenance management could be a complex subject if implementation and planning issues of the building facility are not handled properly. In this context, the current…
(more)
▼ Maintenance management could be a complex subject if implementation and planning
issues of the building facility are not handled properly. In this context, the current
maintenance management method has affected the efficiency of the building facility
management at Polytechnics. Many issues such as poor service delivery, inadequate
finance, poor maintenance planning and maintenance backlogs were emerged due to the
usage of conventional method application (paper-based form and unsystematic database).
Therefore, this research is to review existing maintenance management practices, and
subsequently develop a prototype system based on the stated problems related to the
conventional method in improving the maintenance management processes.
Literature review and semi-structured interview was carried out to achieve the
objectives. Eight Polytechnics are selected based on major problems of using
conventional method in the comparison to investigate the maintenance management
practices in each Polytechnic. There are around 32 Polytechnics in Malaysia and almost
are using conventional methods. The number is considered very big indicating that the
use of modern Information and Communication Technology (ICT) is still very limited
compared to other institutions of higher learning in Malaysia. The results revealed that
the practice of maintenance management at Polytechnics needs to be improved and a
computerised system was proposed based on the requirements of a maintenance
management system identified through the case studies.
The framework was encapsulated in a computer-based prototype system based on
Microsoft Visual Basic.Net as a graphical user-interface while for the database design,
the Microsoft Access is used to deploy the information for maintenance management
processes. The computerised system was developed using Data Flow Diagram (DFD) and
vi
coding. Subsequently, the prototype system was tested by running it until the critical
problems were fixed and its functional requirements work correctly. This system will
help with the building diagnosis and decision making process approaches. It will assist
staff in facilitating the maintenance identification, assessment, planning and execution in
relation to building facility. In conclusion, the developed prototype system can improve
the maintenance management practices effectiveness for building facility to provide high-
quality building facility for safe and healthy environment.
Subjects/Keywords: TH3301-3411 Maintenance and repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ismail, Z. (2013). DMOSYS: defect monitoring system for building maintenance at polytechnic. (Masters Thesis). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/id/eprint/5456/
Chicago Manual of Style (16th Edition):
Ismail, Zul-Atfi. “DMOSYS: defect monitoring system for building maintenance at polytechnic.” 2013. Masters Thesis, Universiti Tun Hussein Onn Malaysia. Accessed April 12, 2021.
http://eprints.uthm.edu.my/id/eprint/5456/.
MLA Handbook (7th Edition):
Ismail, Zul-Atfi. “DMOSYS: defect monitoring system for building maintenance at polytechnic.” 2013. Web. 12 Apr 2021.
Vancouver:
Ismail Z. DMOSYS: defect monitoring system for building maintenance at polytechnic. [Internet] [Masters thesis]. Universiti Tun Hussein Onn Malaysia; 2013. [cited 2021 Apr 12].
Available from: http://eprints.uthm.edu.my/id/eprint/5456/.
Council of Science Editors:
Ismail Z. DMOSYS: defect monitoring system for building maintenance at polytechnic. [Masters Thesis]. Universiti Tun Hussein Onn Malaysia; 2013. Available from: http://eprints.uthm.edu.my/id/eprint/5456/
23.
Zuraidi, Siti Nor Fatimah.
Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah.
Degree: Fakulti Kejuruteraan Awam dan Alam Sekitar, 2014, Universiti Tun Hussein Onn Malaysia
URL: http://eprints.uthm.edu.my/id/eprint/6331/
► Malaysia merupakan sebuah negara yang sedang pesat membangun. Arus pembangunan yang pesat ini terdapat bangunan yang penuh dengan kesan sejarah yang menarik. Hasil daripada penyelidikan,…
(more)
▼ Malaysia merupakan sebuah negara yang sedang pesat membangun. Arus pembangunan yang pesat ini terdapat bangunan yang penuh dengan kesan sejarah yang menarik. Hasil daripada penyelidikan, didapati bahawa ada di antara bangunan bersejarah ini tidak dipulihara dengan baik malah ada yang telah dirobohkan kerana terdapat banyak kesan kecacatan yang berlaku dan keadaan seumpama ini telah mencacatkan keindahan dan keunikan rupa bentuknya. Kajian ini menggunakan kaedah soal selidik dan tinjauan tapak. Soal selidik diedarkan kepada 35 responden dan telah dikembalikan sebanyak 34 responden yang terdiri daripada pihak pengurusan, kontraktor, arkitek, juruukur bahan dan perunding. Data kajian dianalisis menggunakan Statistical Packages for Social Sciences (SPSS) dengan berpandukan statistik deskriptif dan frekuensi untuk mendapatkan nilai peratusan, min dan kekerapan. Hasil analisis objektif pertama telah mengenal pasti sebanyak 8 jenis kerosakan dan kecacatan yang sering berlaku pada elemen bangunan bersejarah iaitu bumbung, dinding, siling, lantai, pintu, tingkap, tangga dan tiang. Hasil análisis objektif kedua telah menemui sebanyak 13 punca kerosakan dan kecacatan iaitu kelemahan pada rekabentuk, mutu kerja rendah, kualiti bahan yang rendah, kelembapan, kecuaian, projek pembinaan berdekatan kawasan bangunan, serangan serangga perosak, pergerakan dalam tanah, kegagalan pada bahagian sambungan, ketidakstabilan struktur bangunan, ketidakseimbangan bahan binaan pada fasad bangunan, kehadiran garam yang terhasil daripada proses penghabluran dan pengecutan bahan binaan. Hasil daripada analisis, beberapa cadangan telah dirangkakan bagi kerja pemuliharaan struktur fabrik pada bangunan bersejarah untuk dijadikan sebagai rujukan dan garis panduan kepada pihak pengurusan, kontraktor, arkitek, juruukur bahan dan perunding dalam usaha untuk memulihara bangunan bersejarah. Diharapkan kajian ini akan diteruskan oleh penyelidik dalam mengkaji implikasi undang-undang dan garis panduan bagi kerja- kerja pemuliharaan bangunan bersejarah.
Subjects/Keywords: TH3301-3411 Maintenance and repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zuraidi, S. N. F. (2014). Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah. (Masters Thesis). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/id/eprint/6331/
Chicago Manual of Style (16th Edition):
Zuraidi, Siti Nor Fatimah. “Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah.” 2014. Masters Thesis, Universiti Tun Hussein Onn Malaysia. Accessed April 12, 2021.
http://eprints.uthm.edu.my/id/eprint/6331/.
MLA Handbook (7th Edition):
Zuraidi, Siti Nor Fatimah. “Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah.” 2014. Web. 12 Apr 2021.
Vancouver:
Zuraidi SNF. Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah. [Internet] [Masters thesis]. Universiti Tun Hussein Onn Malaysia; 2014. [cited 2021 Apr 12].
Available from: http://eprints.uthm.edu.my/id/eprint/6331/.
Council of Science Editors:
Zuraidi SNF. Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah. [Masters Thesis]. Universiti Tun Hussein Onn Malaysia; 2014. Available from: http://eprints.uthm.edu.my/id/eprint/6331/

Cornell University
24.
Hartford, Suzanne.
The Role For Dna Replication And Repair Genes In Germ-Line Maintenance And Tumor Suppression.
Degree: PhD, Genetics, 2012, Cornell University
URL: http://hdl.handle.net/1813/29477
► : Faithful DNA replication and repair of DNA damage is important for prevention of disease and birth defects. My thesis work utilized reverse and forward…
(more)
▼ : Faithful DNA replication and
repair of DNA damage is important for prevention of disease and birth defects. My thesis work utilized reverse and forward genetic approaches to identify novel genes involved in these processes. In one set of studies, I investigated the function of MCM9, a protein specific to multicellular eukaryotes that is related to subunits of the DNA replicative helicase. Utilizing multiple mouse disruption alleles, I have shown MCM9 is dispensable for DNA replication, however it has a role in germ-line stem cell maintenance and/or proliferation. Additionally, in the soma, Mcm9 mutation leads to increased cancer susceptibility, particularly hepatocellular carcinoma in males. The phenotypes of MCM9 mutant mice and cells suggest that MCM9 evolved a specialized but nonessential role in DNA replication or replication-linked quality-control mechanisms. In a second set of studies, I identified a hypomorphic allele of Fancm in a forward genetic screen for GIN mutations in mice. Fancm is a member of the Fanconi Anemia complementation group and facilitates
repair of lesions at the DNA replication fork. Similar to Mcm9, Fancm is required for producing a normal germ-line stem cell pool and for tumor suppression in the soma. Together, these genetic studies underscore the importance of accurate DNA replication and
repair of replication-associated damage in mammalian reproduction and cancer.
Advisors/Committee Members: Schimenti, John C. (chair), Weiss, Robert S. (committee member), Tye, Bik-Kwoon (committee member).
Subjects/Keywords: DNA Replication; DNA Repair; mcm9
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hartford, S. (2012). The Role For Dna Replication And Repair Genes In Germ-Line Maintenance And Tumor Suppression. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/29477
Chicago Manual of Style (16th Edition):
Hartford, Suzanne. “The Role For Dna Replication And Repair Genes In Germ-Line Maintenance And Tumor Suppression.” 2012. Doctoral Dissertation, Cornell University. Accessed April 12, 2021.
http://hdl.handle.net/1813/29477.
MLA Handbook (7th Edition):
Hartford, Suzanne. “The Role For Dna Replication And Repair Genes In Germ-Line Maintenance And Tumor Suppression.” 2012. Web. 12 Apr 2021.
Vancouver:
Hartford S. The Role For Dna Replication And Repair Genes In Germ-Line Maintenance And Tumor Suppression. [Internet] [Doctoral dissertation]. Cornell University; 2012. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1813/29477.
Council of Science Editors:
Hartford S. The Role For Dna Replication And Repair Genes In Germ-Line Maintenance And Tumor Suppression. [Doctoral Dissertation]. Cornell University; 2012. Available from: http://hdl.handle.net/1813/29477

Cornell University
25.
Plys, Aaron.
Analysis Of The Movement Of Saccharomyces Cerevisiae Mismatch Repair Proteins On Dna.
Degree: PhD, Biochemistry, 2011, Cornell University
URL: http://hdl.handle.net/1813/30604
► Replication errors that escape DNA polymerase proof-reading activity are efficientl y recognized and repaired by conserved DNA mismatch repair factors. The overall result is a…
(more)
▼ Replication errors that escape DNA polymerase proof-reading activity are efficientl y recognized and repaired by conserved DNA mismatch
repair factors. The overall result is a drastic reduction in deletion mutations. The mechanistic details of how mismatch
repair proteins execute mismatch removal have not been elucidated. The aim of my thesis is to better understand how mismatch
repair factors interact with DNA in order to identify mismatch sites. My work reveals that the mismatch
repair complex, MLH1-PMS1, has unique DNA diffusion characteristics facilitated by structural features of the two subunits. Through bulk assays and total internal reflectance fluorescence microscopy (TIRFM), I found that MLH1PMS1 could independently bind DNA and rapidly diffuse using the thermal energy of the system. Furthermore, MLH1-PMS1 was shown to be the first passively diffusing protein that could bypass stationary nucleosomes. In contrast, the DNA diffusion activity of the mismatch recognition complex MSH2-MSH6 was blocked by nucleosomes. The timing and nature of mismatch
repair is linked with replication and is thus proposed that the differences seen for the two complexes have important implications for
repair in the context of the chromatin state directly at the replication fork. Each subunit of the MLH1-PMS1 complex is composed of two defined globular domains connected by an unstructured linker arm. The linker arms of the complex are proposed to facilitate topological DNA binding and diffusion along DNA in a hopping/stepping mechanism. I found that TEV protease cleavage within the linker arms of MLH1-PMS1 disrupted DNA binding and mismatch
repair in vitro and in vivo. Using a genetic mismatch
repair assay I found that shortening of the linker arms in MLH1 had a drastic effect on function whereas similar changes in PMS1 had little or no effect. Purified truncated complexes were able to interact with DNA and form ternary complexes with MSH2-MSH6 at a mismatch. Future studies should focus on the diffusion characteristic for these complexes. Together, my work has important implications for understanding how mismatch
repair proteins can rapidly identify their targets in a chromatin landscape.
Advisors/Committee Members: Alani, Eric E (chair), Collins, Ruth N. (coChair), Weiss, Robert S. (committee member).
Subjects/Keywords: DNA mismatch repair; Replication; Cancer
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Plys, A. (2011). Analysis Of The Movement Of Saccharomyces Cerevisiae Mismatch Repair Proteins On Dna. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/30604
Chicago Manual of Style (16th Edition):
Plys, Aaron. “Analysis Of The Movement Of Saccharomyces Cerevisiae Mismatch Repair Proteins On Dna.” 2011. Doctoral Dissertation, Cornell University. Accessed April 12, 2021.
http://hdl.handle.net/1813/30604.
MLA Handbook (7th Edition):
Plys, Aaron. “Analysis Of The Movement Of Saccharomyces Cerevisiae Mismatch Repair Proteins On Dna.” 2011. Web. 12 Apr 2021.
Vancouver:
Plys A. Analysis Of The Movement Of Saccharomyces Cerevisiae Mismatch Repair Proteins On Dna. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1813/30604.
Council of Science Editors:
Plys A. Analysis Of The Movement Of Saccharomyces Cerevisiae Mismatch Repair Proteins On Dna. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/30604
26.
Mohd Abdullah, Muhamad Shahril.
The criteria and potential adaptive reuse of pre-war shophouses.
Degree: mphil, Faculty of Civil and Environmental Engineering, 2018, Universiti Tun Hussein Onn Malaysia
URL: http://eprints.uthm.edu.my/id/eprint/12623/
► Pre-war shophouses in some town areas of Malaysia are among national heritage buildings which require conservation efforts, among other through adaptive reuse. Adaptive reuse, in…
(more)
▼ Pre-war shophouses in some town areas of Malaysia are among national heritage
buildings which require conservation efforts, among other through adaptive reuse.
Adaptive reuse, in line with sustainability principles, is a process to revitalise or
reinvent disused or ineffective existing buildings including old or historical buildings
for new use, purpose or function. The aim of this study is to propose the decisionmaking
in selecting the optimal reuse of pre-war shophouses by considering the
importance criteria that are influenced the adaptive reuse process. A questionnaire
survey among four (4) selective respondents consist of town planner from local
authorities, valuer from valuation and property service department (JPPH), architects
and building owners conducted to achieve the objectives. From the analysis, five (5)
potential new uses which are new shophouses, pharmacy hotel, rental house anda
restaurant were identified as a very suitable. Thirty-three (33) criteria were classified
into six aspects which are economic, environment, social, architecture, technology,
and legislative. Out of them, sixteen (16) criteria were identified as very important to
be considered in deciding adaptive reuse for pre-war shophouses. The outcome of
this study is a conceptual framework that can assist stakeholders, especially local
authorities, Valuation and Property Service Department (JPPH), architects and
building owners, in adaptive reuse decision-making process. This conceptual
framework proposedly can be used by architects as the main actors in adaptive reuse
process, building owners since they are the most entitle person to decide any
conversion on their buildings, and government bodies since they are involved
directly in preparing the guidelines for conservation of pre-war shophouse.
Subjects/Keywords: TH3301-3411 Maintenance and repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mohd Abdullah, M. S. (2018). The criteria and potential adaptive reuse of pre-war shophouses. (Masters Thesis). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/id/eprint/12623/
Chicago Manual of Style (16th Edition):
Mohd Abdullah, Muhamad Shahril. “The criteria and potential adaptive reuse of pre-war shophouses.” 2018. Masters Thesis, Universiti Tun Hussein Onn Malaysia. Accessed April 12, 2021.
http://eprints.uthm.edu.my/id/eprint/12623/.
MLA Handbook (7th Edition):
Mohd Abdullah, Muhamad Shahril. “The criteria and potential adaptive reuse of pre-war shophouses.” 2018. Web. 12 Apr 2021.
Vancouver:
Mohd Abdullah MS. The criteria and potential adaptive reuse of pre-war shophouses. [Internet] [Masters thesis]. Universiti Tun Hussein Onn Malaysia; 2018. [cited 2021 Apr 12].
Available from: http://eprints.uthm.edu.my/id/eprint/12623/.
Council of Science Editors:
Mohd Abdullah MS. The criteria and potential adaptive reuse of pre-war shophouses. [Masters Thesis]. Universiti Tun Hussein Onn Malaysia; 2018. Available from: http://eprints.uthm.edu.my/id/eprint/12623/

Vanderbilt University
27.
Sugitani, Norie.
Structural and Biophysical Characterization of the Nucleotide Excision Repair Factor XPA.
Degree: PhD, Chemistry, 2017, Vanderbilt University
URL: http://hdl.handle.net/1803/11009
► Maintaining the integrity of the genome is critical for the survival of all organisms. Genome maintenance must be efficient because we are constantly under exposure…
(more)
▼ Maintaining the integrity of the genome is critical for the survival of all organisms. Genome maintenance must be efficient because we are constantly under exposure to genotoxic agents including UV-light, endogenous and exogenous reactive oxygen species, and chemical compounds from the environment. These toxins give rise to a variety of DNA lesions ranging from single strand breaks, abasic sites, cross-links and covalent adducts. Persistence of these lesions in the genome can lead directly to apoptosis of the cell or result in mutations, which in turn can lead to carcinogenesis. To combat genetic instability, multiple pathways have evolved to efficiently
repair different types of DNA lesions. Nucleotide excision
repair (NER) is a
repair pathway specialized for removing bulky DNA lesions, typically arising from exposure to sun light, chemical carcinogens in the environment, and certain natural metabolites.
Xeroderma pigmentosum complementation group A (XPA) protein is an essential scaffolding protein in the NER machinery. Its importance is underscored by the observation that XPA mutations are frequently associated with severe clinical symptoms of genetic disorder xeroderma pigmentosum (XP). The interaction of XPA with DNA is a core function and a number of mutations in the DNA binding domain are associated with XP disease, suggesting the importance of XPA-DNA interaction in human NER. Although early NMR structures of human XPA and complementary data on DNA binding are available, molecular details of how human XPA binds DNA remain unclear. Moreover, DNA binding of XPA is likely linked to its interaction with another NER factor replication protein A (RPA).
This dissertation focused on elucidating the molecular basis of XPA-DNA interaction in the context of human NER. A combination of sequence analysis and a series of DNA binding assays redefined the DNA binding construct of XPA (XPA DBD), which had been misidentified for nearly 20 years. NMR studies identified key residues within the XPA DBD that are involved in interactions with DNA and RPA70AB. Moreover, biochemical studies of mutations within XPA DBD provided initial insights into genotype-phenotype correlations for these mutations and XP disease. Findings from this study enhance the mechanistic understanding of human NER and XP disorders.
Advisors/Committee Members: Dr. David Cortez (committee member), Dr. Brandt Eichman (committee member), Dr. Carmelo Rizzo (committee member), Dr. Jens Meiler (committee member), Dr. Walter J. Chazin (Committee Chair).
Subjects/Keywords: NER; XPA; DNA repair; RPA
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sugitani, N. (2017). Structural and Biophysical Characterization of the Nucleotide Excision Repair Factor XPA. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11009
Chicago Manual of Style (16th Edition):
Sugitani, Norie. “Structural and Biophysical Characterization of the Nucleotide Excision Repair Factor XPA.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed April 12, 2021.
http://hdl.handle.net/1803/11009.
MLA Handbook (7th Edition):
Sugitani, Norie. “Structural and Biophysical Characterization of the Nucleotide Excision Repair Factor XPA.” 2017. Web. 12 Apr 2021.
Vancouver:
Sugitani N. Structural and Biophysical Characterization of the Nucleotide Excision Repair Factor XPA. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1803/11009.
Council of Science Editors:
Sugitani N. Structural and Biophysical Characterization of the Nucleotide Excision Repair Factor XPA. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/11009

Vanderbilt University
28.
Adeleke, Adeola.
Logic repair and soft error rate reduction using approximate logic functions.
Degree: MS, Electrical Engineering, 2012, Vanderbilt University
URL: http://hdl.handle.net/1803/10736
► Continuing CMOS devices scaling causes an increase in the vulnerability of integrated circuits to radiation-induced soft errors. Furthermore, as transistor density increases, the probability of…
(more)
▼ Continuing CMOS devices scaling causes an increase in the vulnerability of integrated circuits to radiation-induced soft errors. Furthermore, as transistor density increases, the probability of transistors failing increases accordingly. Consequently, design approaches that address these threats to architectural reliability are required. Existing techniques for providing hardware robustness often require incurring significant area, power, speed, and weight penalties. Moreover, many of the existing techniques are only applicable to memory elements. In this project, a new technique for soft error rate reduction and logic
repair using approximate logic functions has been developed. By utilizing this technique, designers can flexibly select the protection level of logic circuits while balancing out design trade-offs
Advisors/Committee Members: Lloyd W. Massengill (committee member), Bharat L. Bhuva (Committee Chair).
Subjects/Keywords: functions; logic; approximate; logic; repair
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Adeleke, A. (2012). Logic repair and soft error rate reduction using approximate logic functions. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10736
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Adeleke, Adeola. “Logic repair and soft error rate reduction using approximate logic functions.” 2012. Thesis, Vanderbilt University. Accessed April 12, 2021.
http://hdl.handle.net/1803/10736.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Adeleke, Adeola. “Logic repair and soft error rate reduction using approximate logic functions.” 2012. Web. 12 Apr 2021.
Vancouver:
Adeleke A. Logic repair and soft error rate reduction using approximate logic functions. [Internet] [Thesis]. Vanderbilt University; 2012. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1803/10736.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Adeleke A. Logic repair and soft error rate reduction using approximate logic functions. [Thesis]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/10736
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University
29.
McNutt, Jacob Noel.
Damage repair of bridge superstructures using bonded composite patching.
Degree: MS, Civil Engineering, 2011, Vanderbilt University
URL: http://hdl.handle.net/1803/13376
► Many of the steel and concrete bridges built in the 20th century are reaching the end of their planned service life in the early part…
(more)
▼ Many of the steel and concrete bridges built in the 20th century are reaching the end of their planned service life in the early part of the new century. Corrosion and fatigue fracture of steel, and cracking, spalling, or delamination of concrete are common deteriorations due to harsh environments. The structural deficiency of these bridges is further aggravated by heavier and faster traffic loads than what they were originally designed. Effective life management of the large number of deficient and/or obsolete bridges with limited budgets requires post-strengthening, retrofitting, or
repair, with minimum interference of traffic and cost. In some cases, localized
repair can extend the life for a period of time using a
repair method based on bonded fiber-reinforced polymers (FRP) patches for both steel and concrete bridges. This
repair solution may prove effective for excessive flexural and shear cracks in concrete beams, and section loss of steel beams.This thesis is concerned with predicting the performance of such patch repaired beams using mechanistic modeling and experimental testing. Steel, reinforced concrete, and prestressed concrete beams test beams are utilized and the predicted response values are compared and validated.
Advisors/Committee Members: Curtis Byers (committee member), P.K. Basu (Committee Chair).
Subjects/Keywords: repair; bridge; composite; FRP
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McNutt, J. N. (2011). Damage repair of bridge superstructures using bonded composite patching. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13376
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McNutt, Jacob Noel. “Damage repair of bridge superstructures using bonded composite patching.” 2011. Thesis, Vanderbilt University. Accessed April 12, 2021.
http://hdl.handle.net/1803/13376.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McNutt, Jacob Noel. “Damage repair of bridge superstructures using bonded composite patching.” 2011. Web. 12 Apr 2021.
Vancouver:
McNutt JN. Damage repair of bridge superstructures using bonded composite patching. [Internet] [Thesis]. Vanderbilt University; 2011. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1803/13376.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McNutt JN. Damage repair of bridge superstructures using bonded composite patching. [Thesis]. Vanderbilt University; 2011. Available from: http://hdl.handle.net/1803/13376
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University
30.
Shao, Shuo.
Fundamental Limits of Exact-Repair Regenerating Codes.
Degree: PhD, Electrical Engineering, 2017, Texas A&M University
URL: http://hdl.handle.net/1969.1/161617
► Understanding the fundamental limits of communication systems involves both constructing efficient coding schemes as well as proving mathematically that certain performance is impossible to achieve;…
(more)
▼ Understanding the fundamental limits of communication systems involves both constructing efficient coding schemes as well as proving mathematically that certain performance is impossible to achieve; the latter is known as the converse problem in information theory. This thesis focused on the converse problems for complex information systems such as self-
repair distributed storage and coded caching systems, and our goal was to establish tight converse results for such systems by exploiting problem-specific combinatorial structures.
The main part of this thesis dealt with exact-
repair regenerating codes, which were first proposed by Dimakis et al. in 2010. In particular, we considered two extensions of the original setting of Dimakis et al., namely 1) multilevel diversity coding with regeneration and 2) secure exact-
repair regenerating codes. For the problem of multilevel diversity coding with regeneration, we showed, via the proposed combinatorial approach, that the natural separate encoding strategy can achieve the optimal tradeoff between the normalized storage capacity and
repair bandwidth at the minimum-bandwidth rate (MBR) point. This settled a conjecture by Tian and Liu in 2015.
For the problem of secure exact-
repair regenerating codes, all known results from the literature showed that the achievable tradeoff regions between the normalized storage capacity and
repair bandwidth have a single corner point, achieved by a scheme proposed by Shah, Rashmi and Kumar (the SRK point). Since the achievable tradeoff regions of the exact-
repair regenerating code problem without any secrecy constraints were known to have multiple corner points in general, these existing results suggested a phase-change-like behavior, i.e., enforcing a secrecy constraint immediately reduces the tradeoff region to one with a single corner point. In our work, we first showed that when the secrecy parameter is sufficiently large, the SRK point is indeed the only corner point of the tradeoff region. However, when the secrecy parameter is small, we showed that the tradeoff region can, in fact, have multiple corner points. In particular, we established a precise characterization of the tradeoff region for a particular problem instance, which has exactly two corner points. Thus, a smooth transition, instead of a phase-change-type of transition, should be expected as the secrecy constraint is gradually strengthened.
Advisors/Committee Members: Liu, Tie (advisor), Chamberland-Tremblay, Jean-Francois (committee member), Qian, Xiaoning (committee member), Anshelevich, Michael (committee member).
Subjects/Keywords: exact-repair regenerating codes
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Shao, S. (2017). Fundamental Limits of Exact-Repair Regenerating Codes. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/161617
Chicago Manual of Style (16th Edition):
Shao, Shuo. “Fundamental Limits of Exact-Repair Regenerating Codes.” 2017. Doctoral Dissertation, Texas A&M University. Accessed April 12, 2021.
http://hdl.handle.net/1969.1/161617.
MLA Handbook (7th Edition):
Shao, Shuo. “Fundamental Limits of Exact-Repair Regenerating Codes.” 2017. Web. 12 Apr 2021.
Vancouver:
Shao S. Fundamental Limits of Exact-Repair Regenerating Codes. [Internet] [Doctoral dissertation]. Texas A&M University; 2017. [cited 2021 Apr 12].
Available from: http://hdl.handle.net/1969.1/161617.
Council of Science Editors:
Shao S. Fundamental Limits of Exact-Repair Regenerating Codes. [Doctoral Dissertation]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/161617
◁ [1] [2] [3] [4] [5] … [123] ▶
.