subject:(Repair)

University of Hong Kong

1. 陳杰; Chen, Jie. Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair.

Degree: PhD, 2015, University of Hong Kong

URL: Chen, J. [陳杰]. (2015). Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5760913. ; http://dx.doi.org/10.5353/th_b5760913 ; http://hdl.handle.net/10722/239633

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Ubiquitylation at DNA double-strand breaks (DSBs) plays a critical role in the orchestration of DNA damage signaling and repair. However, it remains obscure how ubiquitylation… (more)

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Ubiquitylation at DNA double-strand breaks (DSBs) plays a critical role in the orchestration of DNA damage signaling and repair. However, it remains obscure how ubiquitylation reactions and the resulted products are restrained at DSBs. With a bioinformatics approach, the RING finger protein RNF169 was identified as a protein that bears a similar domain organization to RNF168, which is a pivotal E3 ligase that promotes the ubiquitin-mediated DSB response. Upon challenge by ionizing radiation (IR)-induced genotoxic stress, RNF169 migrated to DSBs and docked at RNF168-promoted ubiquitin conjugates. RNF169 competed for ubiquitin conjugates at DSBs; displaced DNA damage signaling and repair proteins, including RNF168 from DNA lesions; and relieved cell cycle arrest at the G2/M checkpoint, indicative of negative roles in the ubiquitin-mediated DSB signaling cascade. However, the cellular role of RNF169, and how RNF169 is regulated remain elusive. To better appreciate how RNF169 restrains DSB ubiquitylation and signaling events, RNF169 protein complexes were purified, and dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) was identified as an RNF169-interacting partner. DYRK1A accumulated at DSBs through its interaction with RNF169 and was crucial for cell resistance to IR-induced genotoxic stress, suggesting a role of DYRK1A in the DNA damage response. In agreement with the negative role of its interacting partner RNF169, ectopically expressed DYRK1A limited the assembly of DNA damage response proteins at neighboring DSBs via its kinase activity. Conversely, ablation of DYRK1A markedly elevated spontaneous p53 binding protein 1 (53BP1) foci, suggesting that DYRK1A might regulate chromatin accessibility. Indeed, depletion of DYRK1A not only significantly promoted DSB repair but also sensitized chromatin to micrococcal nuclease (MNase) digestion. Furthermore, my preliminary data also showed that DYRK1A readily phosphorylated histone H3 at threonine 45, a mark that alters nucleosome stability and conformation. In conclusion, we propose that DYRK1A remodels chromatin at DSB domains, and that the RNF169-DYRK1A complex employs two different mechanisms: competitive inhibition and reduced chromatin accessibility, to limit DNA damage signal from over-spreading on DSB chromatin regions.

published_or_final_version

Biomedical Sciences

Doctoral

Doctor of Philosophy

Subjects/Keywords: DNA repair

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APA (6^th Edition):

陳杰; Chen, J. (2015). Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. (Doctoral Dissertation). University of Hong Kong. Retrieved from Chen, J. [陳杰]. (2015). Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5760913. ; http://dx.doi.org/10.5353/th_b5760913 ; http://hdl.handle.net/10722/239633

Chicago Manual of Style (16^th Edition):

陳杰; Chen, Jie. “Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair.” 2015. Doctoral Dissertation, University of Hong Kong. Accessed July 23, 2019. Chen, J. [陳杰]. (2015). Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5760913. ; http://dx.doi.org/10.5353/th_b5760913 ; http://hdl.handle.net/10722/239633.

MLA Handbook (7^th Edition):

陳杰; Chen, Jie. “Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair.” 2015. Web. 23 Jul 2019.

Vancouver:

陳杰; Chen J. Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. [Internet] [Doctoral dissertation]. University of Hong Kong; 2015. [cited 2019 Jul 23]. Available from: Chen, J. [陳杰]. (2015). Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5760913. ; http://dx.doi.org/10.5353/th_b5760913 ; http://hdl.handle.net/10722/239633.

Council of Science Editors:

陳杰; Chen J. Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. [Doctoral Dissertation]. University of Hong Kong; 2015. Available from: Chen, J. [陳杰]. (2015). Functional characterization of the RNF169-DYRK1A complex in DNA double-strand break signaling and repair. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5760913. ; http://dx.doi.org/10.5353/th_b5760913 ; http://hdl.handle.net/10722/239633

Mississippi State University

2. McLaurin, David Owen. ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR.

Degree: PhD, Aerospace Engineering, 2010, Mississippi State University

URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;

► Computational analysis and design has become a fundamental part of product research, development, and manufacture in aerospace, automotive, and other industries. In general the success… (more)

▼ Computational analysis and design has become a fundamental part of product research, development, and manufacture in aerospace, automotive, and other industries. In general the success of the specific application depends heavily on the accuracy and consistency of the computational model used. The aim of this work is to reduce the time needed to prepare geometry for mesh generation. This will be accomplished by developing tools that semi-automatically repair discrete data. Providing a level of automation to the process of repairing large, complex problems in discrete data will significantly accelerate the grid generation process. The developed algorithms are meant to offer semi-automated solutions to complicated geometrical problemsspecifically discrete mesh intersections and isolated boundaries. The intersection-repair strategy presented here focuses on repairing the intersection in-place as opposed to re-discretizing the intersecting geometries. Combining robust, efficient methods of detecting intersections and then repairing intersecting geometries in-place produces a significant improvement over techniques used in current literature. The result of this intersection process is a non-manifold, non-intersecting geometry that is free of duplicate and degenerate geometry. Results are presented showing the accuracy and consistency of the intersection repair tool. Isolated boundaries are a type of gap that current research does not address directly. They are defined by discrete boundary edges that are unable to be paired with nearby discrete boundary edges in order to fill the existing gap. In this research the method of repair seeks to fill the gap by extruding the isolated boundary along a defined vector so that it is topologically adjacent to a nearby surface. The outcome of the repair process is that the isolated boundaries no longer exist because the gap has been filled. Results are presented showing the precision of the edge projection and the advantage of edge splitting in the repair of isolated boundaries. Advisors/Committee Members: David Marucm (chair), Pasquale Cinnella (chair), Eric Blades (committee member), Mike Remotigue (committee member), David Thompson (committee member).

Subjects/Keywords: mesh repair

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APA (6^th Edition):

McLaurin, D. O. (2010). ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;

Chicago Manual of Style (16^th Edition):

McLaurin, David Owen. “ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR.” 2010. Doctoral Dissertation, Mississippi State University. Accessed July 23, 2019. http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;.

MLA Handbook (7^th Edition):

McLaurin, David Owen. “ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR.” 2010. Web. 23 Jul 2019.

Vancouver:

McLaurin DO. ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR. [Internet] [Doctoral dissertation]. Mississippi State University; 2010. [cited 2019 Jul 23]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;.

Council of Science Editors:

McLaurin DO. ALGORITHMS AND METHODS FOR DISCRETE MESH REPAIR. [Doctoral Dissertation]. Mississippi State University; 2010. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07082010-161545/ ;

Wake Forest University

3. Wang, Rui. INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION.

Degree: 2015, Wake Forest University

URL: http://hdl.handle.net/10339/57276

► The spine may become unstable and fragile due to aging, trauma, or congenital defects. The instability of the spine potentially causes compression on the spinal… (more)

▼ The spine may become unstable and fragile due to aging, trauma, or congenital defects. The instability of the spine potentially causes compression on the spinal cord, which leads to permanent damage and paralysis. In order to reduce the risk of functional impairment, the current surgical treatment is spinal fusion. Spinal fusion is the most common operating room (OR) procedure among all age groups. However, the procedure has the highest total OR cost in the United States, and the high failure rate is due to non-union (Weiss et al. 2014, Rajaee et al. 2012, Stranges et al. 2009). Negative pressure wound therapy (NPWT) or vacuum assisted closure (VAC) has shown superior clinical results when used in combination with biomaterials to accelerate wound healing in treating complicated wound with exposed bone (Wijewardena et al. 2011, DeFranzo et al. 2001). However, NPWT is not established as a treatment modality for orthopedic application and its mechanistic pathways of action on cellular activities is unknown. To support proper bone healing, the goal of this study is to test the central hypothesis that an elastic osteoid mimetic bone repair material fabricated by electrospinning using composites of type I collagen (Col I), poly (1,8-octanediol citrate) (POC), and chondroitin 6-sulfate (CS) named material (BRM), or subatmospheric pressure, or synergy of both promote osteoblast proliferation and osteogenic differentiation. Results indicated that osteoblast proliferation significantly increased when cultured under subatmospheric pressure. The osteogenic gene expression of Runx2, OSX, ALP, OPN, COL1A2, and HIF-1α were elevated in fully differentiated bone marrow mesenchymal stem cells (MSCs), which were cultured on BRM and treated with subatmospheric pressure. When BRM and/or NPWT were implemented in rabbit and sheep models, the bone repair measured from CT images provided evidences for feasibly applying NPWT to repair bone with BRM electrospun materials. The in vitro and in vivo systems in this study suggest that there is a significant interaction of using BRM with NPWT for osteogenesis. Developing biomaterials with affinity to cells and soluble factors driven by pressure gradient could ultimately translate to safe and cost-effective clinical applications that accelerate bone healing for spinal fusion.

Subjects/Keywords: Bone Repair

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APA (6^th Edition):

Wang, R. (2015). INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Rui. “INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION.” 2015. Thesis, Wake Forest University. Accessed July 23, 2019. http://hdl.handle.net/10339/57276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Rui. “INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION.” 2015. Web. 23 Jul 2019.

Vancouver:

Wang R. INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/10339/57276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang R. INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

4. Atkins, Andrew James. Predicting the effects of intracellular protein variation on base excision repair capacity in human cells.

Degree: 2012, Drexel University

URL: http://hdl.handle.net/1860/3765

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Base excision repair (BER) is one of the primary means by which cells cope with genotoxic stress and DNA damage. BER is carried out by… (more)

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Base excision repair (BER) is one of the primary means by which cells cope with genotoxic stress and DNA damage. BER is carried out by a series of enzymes which excise a damaged base from a DNA strand and replace it with an undamaged base. The importance of BER to the maintenance of genomic integrity, cellular health, and the health of an individual cannot be overstated. Numerous diseases, particularly cancer, have been correlated to BER deficiencies in several ways. 1) Increased disease risk has been correlated to elevated levels of highly mutagenic lesions repaired exclusively by the BER pathway. Elevated tissue levels of reactive oxygen species (ROS) which generate such lesions has likewise been correlated to increased disease risk. 2) Some functional variants of BER enzymes have been shown to be correlated with elevated disease risk. 3) Tumor cells have been shown to express BER enzymes at altered levels compared to surrounding healthy tissue.Although the correlation between BER deficiency and disease risk has been thoroughly demonstrated it has not been well characterized. An unrepaired DNA lesion can lead to mutagenesis. Yet all cells cope with thousands of potentially mutagenic lesions each day, the majority of which are repaired without incident. Simply stated, mutagenesis can occur when a cell faces a damage load which exceeds its repair capacity. Therefore the need to characterize the quantitative relationships that govern repair capacity is central to understanding the development of diseases triggered by mutagenesis.To this end I have created a formal model of the BER pathway. To test the model, I established protocols for DNA damage measurement in cultured human cells using single cell gel electrophoresis (SCGE). I developed novel software for the quantitation of SCGE data. In order to measure the system response following a perturbation, I created three cell lines deficient in the critical BER enzyme polymerase β (polβ) using RNA interference (RNAi) on HEK 293t cells. Polβ knockdown was confirmed and quantified with Western blotting. Repair curves were generated for wild type and knockdown cell lines using SCGE. Model validity was tested by comparing model predictions and experimental results.

Ph.D., Biomedical Engineering – Drexel University, 2012

Advisors/Committee Members: Kriete, Andres.

Subjects/Keywords: Biomedical engineering; DNA repair; Base excision repair

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Atkins, A. J. (2012). Predicting the effects of intracellular protein variation on base excision repair capacity in human cells. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/3765

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Atkins, Andrew James. “Predicting the effects of intracellular protein variation on base excision repair capacity in human cells.” 2012. Thesis, Drexel University. Accessed July 23, 2019. http://hdl.handle.net/1860/3765.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Atkins, Andrew James. “Predicting the effects of intracellular protein variation on base excision repair capacity in human cells.” 2012. Web. 23 Jul 2019.

Vancouver:

Atkins AJ. Predicting the effects of intracellular protein variation on base excision repair capacity in human cells. [Internet] [Thesis]. Drexel University; 2012. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1860/3765.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Atkins AJ. Predicting the effects of intracellular protein variation on base excision repair capacity in human cells. [Thesis]. Drexel University; 2012. Available from: http://hdl.handle.net/1860/3765

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

5. Malik, Muhammad Zubair. Combining data structure repair and program repair.

Degree: Electrical and Computer Engineering, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/26034

► Bugs in code continue to pose a fundamental problem for software reliability and cause expensive failures. The process of removing known bugs is termed debugging,… (more)

▼ Bugs in code continue to pose a fundamental problem for software reliability and cause expensive failures. The process of removing known bugs is termed debugging, which is a classic methodology commonly performed before code is deployed. Traditionally, debugging is tedious, often requiring much manual effort. A more recent technique that complements debugging is data structure repair, which handles bugs that make it to deployed systems and lead to erroneous behavior at runtime by modifying erroneous program states to recover from errors. While data structure repair presents a promising basis for dealing with bugs at runtime, it remains computationally expensive. Our thesis is that debugging and data structure repair can be integrated to provide the basis of an effective approach for removing bugs before code is deployed and handling them after it is deployed. We present a bi-directional integration where ideas at the basis of data structure repair assist in automating debugging and vice versa. Our key insight is two-fold: (1)a repair action performed to mutate an erroneous object field value to repair it can be abstracted into a program statement that performs that update correctly; and (2)repair actions that are performed repeatedly to fix the same error can be memoized and re-used. We design, develop, and evaluate two techniques that embody our insight. One, we present an automated debugging technique that leverages a systematic constraint-based data structure repair technique developed in previous work and provides suggestions on how to fix a faulty program. Two, we present repair abstractions that are based on the same central ideas as in our automated debugging technique and memoize how an erroneous state was repaired, which enables prioritizing and re-using repair actions when the same error occurs again. The focus of our work is programs that operate on structurally complex data, e.g., heap-allocated data structures that have complex structural integrity constraints, such as acyclicity. Checking such constraints plays a central role in the techniques that lay at the foundation of our work. These techniques require the user to provide the constraints, which poses a burden on the user. To facilitate the use of constraint-based techniques, we present a third technique to check constraint violations at runtime using graph spectra, which have been studied extensively by mathematicians to capture properties of graphs. We view the heap of an object-oriented program as an edge-labeled graph, which allows us to apply results from graph spectra theory. Experimental results show the effectiveness of using graph spectra as a basis of capturing structural properties of a class of commonly used data structures. Advisors/Committee Members: Khurshid, Sarfraz (advisor).

Subjects/Keywords: Program repair; Data Structure repair; Graph spectra

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APA (6^th Edition):

Malik, M. Z. (2014). Combining data structure repair and program repair. (Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/26034

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Malik, Muhammad Zubair. “Combining data structure repair and program repair.” 2014. Thesis, University of Texas – Austin. Accessed July 23, 2019. http://hdl.handle.net/2152/26034.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Malik, Muhammad Zubair. “Combining data structure repair and program repair.” 2014. Web. 23 Jul 2019.

Vancouver:

Malik MZ. Combining data structure repair and program repair. [Internet] [Thesis]. University of Texas – Austin; 2014. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/2152/26034.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Malik MZ. Combining data structure repair and program repair. [Thesis]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/26034

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

6. Richards, Jody Lyn. Recognition and repair of DNA damage by bacterial adenine glycosylases.

Degree: MS;, Chemistry;, 2008, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959

► E. coli MutY is a base excision repair (BER) glycosylase that excises adenine mispaired opposite 7,8-dihydro-8-oxo-2'-deoxyguanine. MutY has helix-hairpin-helix and Gly/Pro-Asp structural motifs characteristic of… (more)

Subjects/Keywords: DNA repair; Adenine

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APA (6^th Edition):

Richards, J. L. (2008). Recognition and repair of DNA damage by bacterial adenine glycosylases. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959

Chicago Manual of Style (16^th Edition):

Richards, Jody Lyn. “Recognition and repair of DNA damage by bacterial adenine glycosylases.” 2008. Masters Thesis, University of Utah. Accessed July 23, 2019. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959.

MLA Handbook (7^th Edition):

Richards, Jody Lyn. “Recognition and repair of DNA damage by bacterial adenine glycosylases.” 2008. Web. 23 Jul 2019.

Vancouver:

Richards JL. Recognition and repair of DNA damage by bacterial adenine glycosylases. [Internet] [Masters thesis]. University of Utah; 2008. [cited 2019 Jul 23]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959.

Council of Science Editors:

Richards JL. Recognition and repair of DNA damage by bacterial adenine glycosylases. [Masters Thesis]. University of Utah; 2008. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/550/rec/959

Queens University

7. Sierant, Megan. Novel Aspects to the Role of Rad9A During the DNA Damage Response .

Degree: Biochemistry, 2010, Queens University

URL: http://hdl.handle.net/1974/6138

► The human Rad9A checkpoint protein is required for genomic stability and proper execution of the DNA damage checkpoint. Previous work has shown Rad9A to be… (more)

Subjects/Keywords: Checkpoint; DNA Repair

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APA (6^th Edition):

Sierant, M. (2010). Novel Aspects to the Role of Rad9A During the DNA Damage Response . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sierant, Megan. “Novel Aspects to the Role of Rad9A During the DNA Damage Response .” 2010. Thesis, Queens University. Accessed July 23, 2019. http://hdl.handle.net/1974/6138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sierant, Megan. “Novel Aspects to the Role of Rad9A During the DNA Damage Response .” 2010. Web. 23 Jul 2019.

Vancouver:

Sierant M. Novel Aspects to the Role of Rad9A During the DNA Damage Response . [Internet] [Thesis]. Queens University; 2010. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1974/6138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sierant M. Novel Aspects to the Role of Rad9A During the DNA Damage Response . [Thesis]. Queens University; 2010. Available from: http://hdl.handle.net/1974/6138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

8. Baddock, Hannah. Understanding the role of the SNM1B and EXD2 in DNA damage repair.

Degree: PhD, 2017, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895

► Unrepaired, or misrepaired, DNA damage can be carcinogenic or mutagenic; thus functional DNA damage repair pathways are essential for the safeguarding of the genome. SNM1B… (more)

Subjects/Keywords: DNA damage repair

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APA (6^th Edition):

Baddock, H. (2017). Understanding the role of the SNM1B and EXD2 in DNA damage repair. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895

Chicago Manual of Style (16^th Edition):

Baddock, Hannah. “Understanding the role of the SNM1B and EXD2 in DNA damage repair.” 2017. Doctoral Dissertation, University of Oxford. Accessed July 23, 2019. http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895.

MLA Handbook (7^th Edition):

Baddock, Hannah. “Understanding the role of the SNM1B and EXD2 in DNA damage repair.” 2017. Web. 23 Jul 2019.

Vancouver:

Baddock H. Understanding the role of the SNM1B and EXD2 in DNA damage repair. [Internet] [Doctoral dissertation]. University of Oxford; 2017. [cited 2019 Jul 23]. Available from: http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895.

Council of Science Editors:

Baddock H. Understanding the role of the SNM1B and EXD2 in DNA damage repair. [Doctoral Dissertation]. University of Oxford; 2017. Available from: http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895

9. O'NEILL, MAEVE. Biomechanics of Repair in Invertebrates.

Degree: School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019, Trinity College Dublin

URL: http://hdl.handle.net/2262/85998

► Repair is a ubiquitous process in nature, and it is one of the many features of biological materials that humans are constantly attempting to recreate.… (more)

▼ Repair is a ubiquitous process in nature, and it is one of the many features of biological materials that humans are constantly attempting to recreate. Though the process of repair has been studied in mammals, very little work has been done on other organisms, despite mammals representing just a minuscule percentage of global biodiversity. This thesis bridges some of these gaps in the knowledge, focusing of the repair process in two different organisms, the desert locust (Schistocerca gregaria) and the common limpet (Patella vulgata). For the locusts a link was drawn between age and repair capabilities, similar to that observed in mammals, finding that older insects are less capable of repair. Both young and old insects repair damage by the deposition of fresh material. Older cuticle was also found to have a decreased fracture toughness. This has implications for energy storage for jumping manoeuvres which was found to involve the deformation of the stiff tibial cuticle. This deformation causes microdamage to the cuticle, in addition to the viscoelastic changes in behaviour, and poses the potential risk of fatigue failure in cuticle. This damage is repaired in a week, similar to the repair of microcracks in bone. The fracture toughness of the limpet shells was similarly evaluated and found to be much higher than that of its main component, calcium carbonate. Several toughening mechanisms that help to achieve this were identified. The limpets were also found to be similarly susceptible to fatigue failure, though some remodelling process may be occurring. The limpets are also capable to repairing damage to their shells, and like the locusts they achieve this by depositing fresh material, though another unidentified mechanism is at work. Throughout this thesis comparisons were made to repair in mammalian bone. Bone has been very thoroughly studied and the mechanisms of repair are well understood. Several of the effects discussed in this thesis mirror effects observed in bone. Consequently, comparisons to bone are drawn to give greater context and enable discussion about the studies. Advisors/Committee Members: Taylor, David.

Subjects/Keywords: Repair; Ivertebrate; Biomechanics

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APA (6^th Edition):

O'NEILL, M. (2019). Biomechanics of Repair in Invertebrates. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/85998

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O'NEILL, MAEVE. “Biomechanics of Repair in Invertebrates.” 2019. Thesis, Trinity College Dublin. Accessed July 23, 2019. http://hdl.handle.net/2262/85998.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O'NEILL, MAEVE. “Biomechanics of Repair in Invertebrates.” 2019. Web. 23 Jul 2019.

Vancouver:

O'NEILL M. Biomechanics of Repair in Invertebrates. [Internet] [Thesis]. Trinity College Dublin; 2019. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/2262/85998.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O'NEILL M. Biomechanics of Repair in Invertebrates. [Thesis]. Trinity College Dublin; 2019. Available from: http://hdl.handle.net/2262/85998

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

10. Fu, Qiong, Ph. D. Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2.

Degree: Microbiology, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/46516

► In response to DNA damage, many repair and signaling molecules mobilize rapidly to the sites of DNA double-strand breaks (DSBs). This network of immediate responses… (more)

▼ In response to DNA damage, many repair and signaling molecules mobilize rapidly to the sites of DNA double-strand breaks (DSBs). This network of immediate responses is regulated at the level of post-translational modifications to coordinate DNA repair and checkpoint signaling. Here we investigate the DNA damage-induced oligomeric transitions of the Sae2 protein, an important enzyme in the initiation of DSB repair. Sae2 is a target of multiple phosphorylation events, which we identify and characterize in vivo in budding yeast. Both cell cycle-dependent and DNA damage-induced phosphorylation of Sae2 are important for the cell survival after DNA damage, and the cell cycle-regulated modifications are required to prime the damage-dependent events. We find that Sae2 exists in the form of inactive oligomers that are transiently released into smaller active units by these series of phosphorylation events. DNA damage also triggers removal of Sae2 through autophagy and proteasomal degradation, ensuring that active Sae2 is present only transiently in cells. This analysis provides evidence for a novel type of protein regulation where the activity of an enzyme is controlled dynamically by post-translational modifications that regulate its solubility and oligomeric state. Budding yeast Ess1 is a phosphorylation-specific prolyl isomerase. Its human homolog Pin1 is found to isomerize CtIP, the human functional ortholog of Sae2, and promote the proteasomal degradation of CtIP. However, I could neither detect any interaction between Ess1 and Sae2, nor observe any change in Sae2 protein level while overexpressing wild-type or mutant Ess1, suggesting Ess1 does not act on Sae2, like Pin1 does on CtIP. The increased DNA damage sensitivity of Ess1 mutants indicates that Ess1 is involved in DNA repair, but not related to Sae2. Since Ess1 plays an important role in transcription termination together with a RNA 3’ end processing factor Pcf11, I overexpressed wild-type Pcf11 and found it significantly increased the DNA damage resistance of either wild-type or H164R mutant Ess1 cells, and also the sae2Δ cells. These results imply that Ess1, Pcf11 and Sae2 might contribute to DNA damage repair through transcription termination, which links transcription termination and DNA damage repair together. Advisors/Committee Members: Paull, Tanya T. (advisor), Iyer, Vishwanath R (committee member), Jayaram, Makkuni (committee member), Johnson, Arlen W (committee member), Zhang, Yan (committee member).

Subjects/Keywords: DNA repair; Sae2

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APA (6^th Edition):

Fu, Qiong, P. D. (2014). Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2. (Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/46516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fu, Qiong, Ph D. “Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2.” 2014. Thesis, University of Texas – Austin. Accessed July 23, 2019. http://hdl.handle.net/2152/46516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fu, Qiong, Ph D. “Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2.” 2014. Web. 23 Jul 2019.

Vancouver:

Fu, Qiong PD. Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2. [Internet] [Thesis]. University of Texas – Austin; 2014. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/2152/46516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fu, Qiong PD. Regulation of the activity of a budding yeast DNA damage repair enzyme Sae2. [Thesis]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/46516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Schermerhorn, Kelly. A Kinetic Perspective on DNA Base Excision Repair.

Degree: PhD, Chemistry, 2014, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:386264/

► The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β)… (more)

▼ The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β) and a DNA ligase, and is responsible for repairing single nucleobase and AP site lesions. These enzymes must complete their required task and coordinate with one another to faithfully repair DNA. Deficiencies and incorrect coordination of BER enzymes has been linked to development of several cancers and neurological disorders. Repair of an 8-oxo-7,8-dihydroguanine (8oxoG) lesion within the CAG trinucleotide repeat tract of the huntingtin gene by BER, is implicated in expansion of the repeat tract leading to Huntington’s disease (HD). In this work, we employ transient-state and steady-state kinetic techniques to provide insight into the molecular mechanisms and substrate specificity of BER enzymes to better understand the disorders that arise due to incorrect repair. Moreover, we center our work on examining kinetics of BER enzymes on CAG repeat containing DNA to provide insight into the molecular mechanism of repeat expansion seen in HD. Through examination of kinetics of removal of an 8oxoG lesion by the DNA glycosylase oxoguanine glycosylase 1 (OGG1) from CAG repeat and non-repetitive sequences, and of coordination of OGG1 with APE1, we revealed that BER is initiated by OGG1 and coordinated with APE1 on CAG repeat sequences as well as on non-repetitive sequences. We further examined kinetics of APE1 cleaving DNA on authentic DNA substrates, and commonly used DNA analogs. Kinetics revealed APE1 incises DNA at rate ≥ 700 s-1, making APE1 one of the faster BER enzymes. We observed differences in the rate of APE1 incision on authentic DNA substrate, compared to commonly used analogs. Finally, we examined kinetics of pol β incorporating single and multiple nucleotides on CAG repeat and non-repetitive DNA sequences. While we observed similar kinetics for pol β single-nucleotide incorporation on CAG repeat and non-repetitive sequences, we observed difference in multinucleotide incorporation on CAG repeat versus non-repetitive sequences. The experiments performed here expand our understanding of the action of several BER enzymes, and provide further insight into the molecular mechanism of CAG repeat expansion seen in HD. Advisors/Committee Members: Delaney, Sarah (Director), Cane, David (Reader), Basu, Amit (Reader).

Subjects/Keywords: Base Excision Repair

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APA (6^th Edition):

Schermerhorn, K. (2014). A Kinetic Perspective on DNA Base Excision Repair. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:386264/

Chicago Manual of Style (16^th Edition):

Schermerhorn, Kelly. “A Kinetic Perspective on DNA Base Excision Repair.” 2014. Doctoral Dissertation, Brown University. Accessed July 23, 2019. https://repository.library.brown.edu/studio/item/bdr:386264/.

MLA Handbook (7^th Edition):

Schermerhorn, Kelly. “A Kinetic Perspective on DNA Base Excision Repair.” 2014. Web. 23 Jul 2019.

Vancouver:

Schermerhorn K. A Kinetic Perspective on DNA Base Excision Repair. [Internet] [Doctoral dissertation]. Brown University; 2014. [cited 2019 Jul 23]. Available from: https://repository.library.brown.edu/studio/item/bdr:386264/.

Council of Science Editors:

Schermerhorn K. A Kinetic Perspective on DNA Base Excision Repair. [Doctoral Dissertation]. Brown University; 2014. Available from: https://repository.library.brown.edu/studio/item/bdr:386264/

Brock University

12. Page, Melissa Maire. Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates .

Degree: Department of Biological Sciences, 2011, Brock University

URL: http://hdl.handle.net/10464/3425

► In animals, both stress resistance and longevity appear to be influenced by the insulin/insulin-like growth factor-l signaling (lIS) pathway, the basic organization of which is… (more)

▼ In animals, both stress resistance and longevity appear to be influenced by the insulin/insulin-like growth factor-l signaling (lIS) pathway, the basic organization of which is highly conserved from invertebrates to vertebrates. Reduced lIS or genetic disruption of the lIS pathway leads to the activation of forkhead box transcription factors, which is thought to upregulate the expression of genes involved in enhancing stress resistance, including perhaps key antioxidant enzymes as well as DNA repair enzymes. Enhanced antioxidant and DNA repair capacities may underlie the enhanced cellular stress resistance observed in long-lived animals, however little data is available that directly supports this idea. I used three. experimental approaches to test the association of intracellular antioxidant and DNA base excision repair (BER) capacities with stress resistance and longevity: (1) a comparison of multiple vertebrate endotherm species of varying body masses and longevities; (2) a comparison of long-lived Snell dwarf mice and their normallittermates; and (3) a comparison of hypometabolic animals undergoing hibernation or estivation with their active counterparts. The activities of the five major intracellular antioxidant enzymes as well as the two rate-limiting enzymes in the BER pathway, apurininc/apyrimidinic (AP) endonuclease and polymerase ~, were measured. These measurements were performed in one or more of the following: (1) cultured dermal fibroblasts; (2) brain tissue; (3) heart tissue; (4) liver tissue. My results indicate that antioxidant enzymes are not universally upregulated in association with enhanced stress resistance and longevity. I also did not find that BER enzyme activity was positively correlated with longevity, in an inter-species context, though there was evidence for enhanced BER in long-lived Snell dwarf mice. Thus, while there were instances in which enhanced antioxidant and BER enzyme activities were associated with increased stress resistance and/or longevity, this was not universally the case, indicating that other mechanisms must be involved. These results suggest the need to re-examine existing 'oxidative stress' hypotheses of longevity and probe further into the molecular physiology of longevity to discover its mechanistic basis.

Subjects/Keywords: DNA repair; Longevity

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APA (6^th Edition):

Page, M. M. (2011). Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates . (Thesis). Brock University. Retrieved from http://hdl.handle.net/10464/3425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Page, Melissa Maire. “Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates .” 2011. Thesis, Brock University. Accessed July 23, 2019. http://hdl.handle.net/10464/3425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Page, Melissa Maire. “Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates .” 2011. Web. 23 Jul 2019.

Vancouver:

Page MM. Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates . [Internet] [Thesis]. Brock University; 2011. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/10464/3425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Page MM. Intracellular antioxidant and DNA repair enzymes as correlates of stress resistance and longevity in vertebrates . [Thesis]. Brock University; 2011. Available from: http://hdl.handle.net/10464/3425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Onken, Andrew Garrett. Development Of A High Strength Laminate Repair System.

Degree: MS, Chemical Engineering, 2012, University of North Dakota

URL: https://commons.und.edu/theses/1310

► Composite manufacturing often requires repairs at some point during the life of the part. Working with LM Wind Power, the Chemical and Mechanical Engineering… (more)

▼ Composite manufacturing often requires repairs at some point during the life of the part. Working with LM Wind Power, the Chemical and Mechanical Engineering Departments at the University of North Dakota worked to develop a new laminate repair system to be used in composite repairs. Both chemical and mechanical test methods were explored to analyze various resins in an attempt to increase the interface toughness between the parent laminate and repair laminate. A total of six resins from four suppliers were tested. Differential scanning calorimetry and dynamic mechanical rheological testing were performed to analyze the curing kinetics of each resin tested. Static double cantilever beam and tension-tension fatigue tests were performed to measure the mechanical performance of each resin. All specimens were prepared to mimic that of a large-scale wind turbine blade. Each resin tested was compared to the current repair resin system to determine which choice was best to meet the requirements set for by LM Wind Power for repair laminate improvement. The results indicated that toughened resin performance is superior to that of the current resin system. Along with the analysis of new repair resins, an initiator study was performed. The initiator study was done on the blade resin used for vacuum assisted resin transfer molding (VARTM). Four initiators were tested and compared to the current initiator. Methods included differential scanning calorimetry and rheology. The goal with testing these initiators was to see if changing the initiator would increase the working time while decreasing the overall curing time. To achieve this, the initial viscosity of the resin needed to remain low to ensure a full wet out of the part and once wet out was complete a sharp increase in viscosity would indicate a fast cure. Of the initiators tested, Pulcat from Syrgis Performance Initiators performed better than the others. However, without testing it in production, it is unclear whether or not it is superior to the current initiator MCP-75. Advisors/Committee Members: Brian M. Tande.

Subjects/Keywords: Composites; Laminates; Repair

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APA (6^th Edition):

Onken, A. G. (2012). Development Of A High Strength Laminate Repair System. (Masters Thesis). University of North Dakota. Retrieved from https://commons.und.edu/theses/1310

Chicago Manual of Style (16^th Edition):

Onken, Andrew Garrett. “Development Of A High Strength Laminate Repair System.” 2012. Masters Thesis, University of North Dakota. Accessed July 23, 2019. https://commons.und.edu/theses/1310.

MLA Handbook (7^th Edition):

Onken, Andrew Garrett. “Development Of A High Strength Laminate Repair System.” 2012. Web. 23 Jul 2019.

Vancouver:

Onken AG. Development Of A High Strength Laminate Repair System. [Internet] [Masters thesis]. University of North Dakota; 2012. [cited 2019 Jul 23]. Available from: https://commons.und.edu/theses/1310.

Council of Science Editors:

Onken AG. Development Of A High Strength Laminate Repair System. [Masters Thesis]. University of North Dakota; 2012. Available from: https://commons.und.edu/theses/1310

Louisiana State University

14. Li, Mingyang. DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast.

Degree: PhD, Laboratory and Basic Science Research, 2017, Louisiana State University

URL: https://digitalcommons.lsu.edu/gradschool_dissertations/4186

► In eukaryotes, DNA repair mechanisms detect and repair damaged DNA. DNA damage is primarily caused by a variety of exogenous and endogenous sources. Several… (more)

Subjects/Keywords: DNA repair; DNA damage; Base excision repair; Double-strand break repair

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APA (6^th Edition):

Li, M. (2017). DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast. (Doctoral Dissertation). Louisiana State University. Retrieved from https://digitalcommons.lsu.edu/gradschool_dissertations/4186

Chicago Manual of Style (16^th Edition):

Li, Mingyang. “DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast.” 2017. Doctoral Dissertation, Louisiana State University. Accessed July 23, 2019. https://digitalcommons.lsu.edu/gradschool_dissertations/4186.

MLA Handbook (7^th Edition):

Li, Mingyang. “DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast.” 2017. Web. 23 Jul 2019.

Vancouver:

Li M. DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast. [Internet] [Doctoral dissertation]. Louisiana State University; 2017. [cited 2019 Jul 23]. Available from: https://digitalcommons.lsu.edu/gradschool_dissertations/4186.

Council of Science Editors:

Li M. DNA Base Excision Repair and Double Strand Break Repair in Human Fibroblast. [Doctoral Dissertation]. Louisiana State University; 2017. Available from: https://digitalcommons.lsu.edu/gradschool_dissertations/4186

The Ohio State University

15. Lin, Horng-Jiun. An Illustrated Basic Flute Repair Manual for Professionals.

Degree: DMA, Music, 2008, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1211871566

► This document is a comprehensive flute repair manual for the modern Boehm and Brögger flute mechanisms. Written for college professors and students, as opposed… (more)

Subjects/Keywords: Music; flute; music; flute repair; modern flute mechanism; flute repair manual; illustrated repair manual

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APA (6^th Edition):

Lin, H. (2008). An Illustrated Basic Flute Repair Manual for Professionals. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1211871566

Chicago Manual of Style (16^th Edition):

Lin, Horng-Jiun. “An Illustrated Basic Flute Repair Manual for Professionals.” 2008. Doctoral Dissertation, The Ohio State University. Accessed July 23, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211871566.

MLA Handbook (7^th Edition):

Lin, Horng-Jiun. “An Illustrated Basic Flute Repair Manual for Professionals.” 2008. Web. 23 Jul 2019.

Vancouver:

Lin H. An Illustrated Basic Flute Repair Manual for Professionals. [Internet] [Doctoral dissertation]. The Ohio State University; 2008. [cited 2019 Jul 23]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1211871566.

Council of Science Editors:

Lin H. An Illustrated Basic Flute Repair Manual for Professionals. [Doctoral Dissertation]. The Ohio State University; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1211871566

Louisiana State University

16. Tatum, Danielle Marie. Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast.

Degree: PhD, Medicine and Health Sciences, 2011, Louisiana State University

URL: etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57

► ABSTRACT Nucleotide excision repair (NER) is a highly conserved DNA repair mechanism which deals with a wide variety of bulky, helix-distorting lesions, such as UV-induced… (more)

▼ ABSTRACT Nucleotide excision repair (NER) is a highly conserved DNA repair mechanism which deals with a wide variety of bulky, helix-distorting lesions, such as UV-induced cyclobutane pyrimidine dimers (CPDs). NER is traditionally grouped into two pathways: global genomic repair (GGR), which is operative throughout the genome, and transcription coupled repair (TCR), which is dedicated to rapid repair of the transcribed strand of actively transcribed genes. Though most of the core NER proteins are known, the exact biochemical mechanism of eukaryotic NER remains elusive. This dissertation focused on identifying novel core and accessory factors which function in NER. In the budding yeast Saccharomyces cerevisiae, GGR has previously been shown to be dependent on Rad7 and Rad16. We revealed Elc1, the yeast homolog of human elongin C, as a novel GGR-specific factor. Elc1 is required for GGR, but has no role in TCR. The precise role of Elc1 in GGR remains unknown. Dot1 is a histone methyltransferase whose sole substrate is histone H3 lysine 79 (H3K79). We identified Dot1 as another GGR-specific factor, as deletion of Dot1 or mutation of H3K79 abolishes GGR, but has no effect on TCR. H3K79 can accept up to 3 methyl groups, but Dot1 can only add one by itself. The PAF transcription elongation complex, through facilitating histone modifications, is partially required for dimethylation and fully required for trimethylation of H3K79 by Dot1. We demonstrated that through facilitating these histone modifications, PAF is partially required for GGR. TCR is believed to be triggered by a stalled elongating RNA polymerase II (Pol II) complex. Rad26, the homolog of the human CSB gene, and Rpb9, a nonessential subunit of Pol II, play important roles in TCR. We identified a dual role for PAF in TCR. In the presence of Rad26, PAF plays a positive role, facilitating TCR. In the absence of Rad26, PAF functions as a suppressor of TCR. PAF appears to be a part of a “megasuppressor” complex which includes Rpb4 and the Spt4/Spt5 complex, which also suppress Rad26-independent TCR. The interactions among Pol II, Rad26 and the various TCR suppressors remain to be elucidated.

Subjects/Keywords: nucleotide excision repair; transcription coupled repair; global genomic repair; cyclobutane pyrimidine dimers; RNA polymerase II

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APA (6^th Edition):

Tatum, D. M. (2011). Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57

Chicago Manual of Style (16^th Edition):

Tatum, Danielle Marie. “Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast.” 2011. Doctoral Dissertation, Louisiana State University. Accessed July 23, 2019. etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57.

MLA Handbook (7^th Edition):

Tatum, Danielle Marie. “Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast.” 2011. Web. 23 Jul 2019.

Vancouver:

Tatum DM. Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast. [Internet] [Doctoral dissertation]. Louisiana State University; 2011. [cited 2019 Jul 23]. Available from: etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57.

Council of Science Editors:

Tatum DM. Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast. [Doctoral Dissertation]. Louisiana State University; 2011. Available from: etd-06202011-122520 ; https://digitalcommons.lsu.edu/gradschool_dissertations/57

University of Tennessee – Knoxville

17. Deland, Susan Gail. The Characteristics of Underground Utility Repairs Made in Asphaltic Roadways – Comparing the Use of Grade D Aggregate as a Viable Backfill Option.

Degree: MS, Civil Engineering, 2010, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_gradthes/789

► Abstract Given that most utilities are located beneath public right of ways, it is difficult to perform repairs to the utility without significantly disturbing the… (more)

Subjects/Keywords: Utility Repair; Asphalt Repair; Underground Utility Repair; Utility; Asphalt; Asphalt Restoration; Civil Engineering

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APA (6^th Edition):

Deland, S. G. (2010). The Characteristics of Underground Utility Repairs Made in Asphaltic Roadways – Comparing the Use of Grade D Aggregate as a Viable Backfill Option. (Thesis). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_gradthes/789

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Deland, Susan Gail. “The Characteristics of Underground Utility Repairs Made in Asphaltic Roadways – Comparing the Use of Grade D Aggregate as a Viable Backfill Option.” 2010. Thesis, University of Tennessee – Knoxville. Accessed July 23, 2019. https://trace.tennessee.edu/utk_gradthes/789.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Deland, Susan Gail. “The Characteristics of Underground Utility Repairs Made in Asphaltic Roadways – Comparing the Use of Grade D Aggregate as a Viable Backfill Option.” 2010. Web. 23 Jul 2019.

Vancouver:

Deland SG. The Characteristics of Underground Utility Repairs Made in Asphaltic Roadways – Comparing the Use of Grade D Aggregate as a Viable Backfill Option. [Internet] [Thesis]. University of Tennessee – Knoxville; 2010. [cited 2019 Jul 23]. Available from: https://trace.tennessee.edu/utk_gradthes/789.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Deland SG. The Characteristics of Underground Utility Repairs Made in Asphaltic Roadways – Comparing the Use of Grade D Aggregate as a Viable Backfill Option. [Thesis]. University of Tennessee – Knoxville; 2010. Available from: https://trace.tennessee.edu/utk_gradthes/789

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Mayuga, Gian Paolo Topico. Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールドデノジコシュウフクアヤマリテイセイレッカケンチオクミアワセタコウシンライメモリアーキテクチャ.

Degree: 博士(工学), 2016, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/11007

Subjects/Keywords: memory repair

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APA (6^th Edition):

Mayuga, G. P. T. (2016). Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールドデノジコシュウフクアヤマリテイセイレッカケンチオクミアワセタコウシンライメモリアーキテクチャ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/11007

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mayuga, Gian Paolo Topico. “Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールドデノジコシュウフクアヤマリテイセイレッカケンチオクミアワセタコウシンライメモリアーキテクチャ.” 2016. Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed July 23, 2019. http://hdl.handle.net/10061/11007.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mayuga, Gian Paolo Topico. “Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールドデノジコシュウフクアヤマリテイセイレッカケンチオクミアワセタコウシンライメモリアーキテクチャ.” 2016. Web. 23 Jul 2019.

Vancouver:

Mayuga GPT. Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールドデノジコシュウフクアヤマリテイセイレッカケンチオクミアワセタコウシンライメモリアーキテクチャ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; 2016. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/10061/11007.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mayuga GPT. Highly Reliable Memory Architectures Using Combination of In-Field Self-Repair, ECC and Aging Test : フィールドでの自己修復、誤り訂正、劣化検知を組み合わせた高信頼メモリアーキテクチャ; フィールドデノジコシュウフクアヤマリテイセイレッカケンチオクミアワセタコウシンライメモリアーキテクチャ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; 2016. Available from: http://hdl.handle.net/10061/11007

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Limerick

19. Davis, Niall Francis. Xenogenic extracellular matrices as potential biomaterials for reconstruction of the urinary bladder.

Degree: 2011, University of Limerick

URL: http://hdl.handle.net/10344/1957

►

peer-reviewed

Surgical repair for end stage bladder disease often utilises vascularised, autogenous, mucus-secreting gastrointestinal tissue to either replace the diseased organ or to augment inadequate… (more)

▼

peer-reviewed

Surgical repair for end stage bladder disease often utilises vascularised, autogenous, mucus-secreting gastrointestinal tissue to either replace the diseased organ or to augment inadequate bladder tissue. Postoperatively, the compliance of the bowel is often sufficient to restore the basic shape, structure and function of the urinary bladder, however lifelong postoperative complications are common. Comorbidities that result from interposition of intestinal tissue are classified as metabolic or neuromechanical and their incidence approaches 100%. The debilitating comorbidities and inherent limitations associated with these urological procedures may be mitigated by the availability of alternative, readily available, animal derived extracellular matrix (ECM) scaffolds. ECMs are decellularised, biocompatible, biodegradable biomaterials usually derived from porcine organs. This thesis aims to investigate the potential for replacing and augmenting defective bladder tissue with a biocompatible, porcine derived ECM scaffold in place of autogenous gastrointestinal tissue. In this thesis I found that ECM scaffolds possess important biomechanical limitations for bladder reconstructive purposes. Implantation of ECM into ovine bladder models resulted in significant decreases in bladder capacity and compliance. Therefore, a novel ‘surface-area’ was developed to prevent these biomechanical complications from occurring. After applying this concept to bladder models, results demonstrated that an increase in ECM scaffold surface-area relative to the resected segment of gastrointestinal tissue leads to improved capacity and compliance values after bladder augmentation. The biological properties of two different FDA approved ECM scaffolds were also investigated with particular emphasis on their urological regenerative potential. Findings demonstrated that porcine urinary bladder matrix (UBM) demonstrates significantly greater regenerative potential for bladder tissue compared to porcine small intestinal submucosa (SIS). However, exposure of both ECM scaffolds to a simulated in vivo urine environment significantly impaired their ability to induce effective urothelial regeneration. This led to the development of an in vitro bladder bioreactor that mimicked the urinary bladder’s physiological environment. The bioreactor facilitated the growth of a stratified urothelium on the ECM’s surface and therefore protected the scaffold against the cytotoxic effects of urine prior to in vivo implantation. Findings from this thesis may have important clinical implications as metabolic, infective and malignant complications precipitated by autogenous mucus-secreting epithelium are avoided with porcine ECM scaffolds.

Advisors/Committee Members: McGloughlin, Timothy M., Flood, Hugh D..

Subjects/Keywords: bladder disease; surgical repair

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Davis, N. F. (2011). Xenogenic extracellular matrices as potential biomaterials for reconstruction of the urinary bladder. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/1957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Davis, Niall Francis. “Xenogenic extracellular matrices as potential biomaterials for reconstruction of the urinary bladder.” 2011. Thesis, University of Limerick. Accessed July 23, 2019. http://hdl.handle.net/10344/1957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Davis, Niall Francis. “Xenogenic extracellular matrices as potential biomaterials for reconstruction of the urinary bladder.” 2011. Web. 23 Jul 2019.

Vancouver:

Davis NF. Xenogenic extracellular matrices as potential biomaterials for reconstruction of the urinary bladder. [Internet] [Thesis]. University of Limerick; 2011. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/10344/1957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Davis NF. Xenogenic extracellular matrices as potential biomaterials for reconstruction of the urinary bladder. [Thesis]. University of Limerick; 2011. Available from: http://hdl.handle.net/10344/1957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Shamsuddin , Sharifah Hamimah. Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam.

Degree: Fakulti Kejuruteraan Awam dan Alam Sekitar, 2011, Universiti Tun Hussein Onn Malaysia

URL: http://eprints.uthm.edu.my/1645/

► Penyelenggaraan adalah aktiviti yang dilakukan secara berterusan bagi memastikan fungsi bangunan dapat dilaksanakan sebagaimana fungsinya secara normal. Penyelenggaraan bangunan sekolah adalah aktiviti rutin yang harus… (more)

Subjects/Keywords: TH3301-3411 Maintenance and repair

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APA (6^th Edition):

Shamsuddin , S. H. (2011). Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam. (Masters Thesis). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/1645/

Chicago Manual of Style (16^th Edition):

Shamsuddin , Sharifah Hamimah. “Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam.” 2011. Masters Thesis, Universiti Tun Hussein Onn Malaysia. Accessed July 23, 2019. http://eprints.uthm.edu.my/1645/.

MLA Handbook (7^th Edition):

Shamsuddin , Sharifah Hamimah. “Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam.” 2011. Web. 23 Jul 2019.

Vancouver:

Shamsuddin SH. Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam. [Internet] [Masters thesis]. Universiti Tun Hussein Onn Malaysia; 2011. [cited 2019 Jul 23]. Available from: http://eprints.uthm.edu.my/1645/.

Council of Science Editors:

Shamsuddin SH. Pembangunan dan penganalisisan aplikasi permohonan peruntukkan penyelenggaraan bangunan sekolah berasaskan proses pengurusan dalam kejuruteraan awam. [Masters Thesis]. Universiti Tun Hussein Onn Malaysia; 2011. Available from: http://eprints.uthm.edu.my/1645/

21. Abdul Rahman, Mohammad Ashraf. Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia.

Degree: PhD, Fakulti Kejuruteraan Awam dan Alam Sekitar, 2013, Universiti Tun Hussein Onn Malaysia

URL: http://eprints.uthm.edu.my/4336/

► Pendekatan penyenggaraan seringkali dianggap sebagai aktiviti yang remeh sehinggakan dalam praktis semasa, pendekatan ini tidak dapat menarik perhatian kebanyakkan golongan berpengetahuan dan berkemahiran. Senario ini… (more)

Subjects/Keywords: TH3301-3411 Maintenance and repair

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APA (6^th Edition):

Abdul Rahman, M. A. (2013). Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia. (Doctoral Dissertation). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/4336/

Chicago Manual of Style (16^th Edition):

Abdul Rahman, Mohammad Ashraf. “Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia.” 2013. Doctoral Dissertation, Universiti Tun Hussein Onn Malaysia. Accessed July 23, 2019. http://eprints.uthm.edu.my/4336/.

MLA Handbook (7^th Edition):

Abdul Rahman, Mohammad Ashraf. “Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia.” 2013. Web. 23 Jul 2019.

Vancouver:

Abdul Rahman MA. Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia. [Internet] [Doctoral dissertation]. Universiti Tun Hussein Onn Malaysia; 2013. [cited 2019 Jul 23]. Available from: http://eprints.uthm.edu.my/4336/.

Council of Science Editors:

Abdul Rahman MA. Model kejayaan utama amalan terbaik pengurusan penyenggaraan bangunan warisan di Malaysia. [Doctoral Dissertation]. Universiti Tun Hussein Onn Malaysia; 2013. Available from: http://eprints.uthm.edu.my/4336/

22. Ismail, Zul-Atfi. DMOSYS: defect monitoring system for building maintenance at polytechnic.

Degree: Fakulti Pengurusan Teknologi dan Perniagaan, 2013, Universiti Tun Hussein Onn Malaysia

URL: http://eprints.uthm.edu.my/5456/

► Maintenance management could be a complex subject if implementation and planning issues of the building facility are not handled properly. In this context, the current… (more)

▼ Maintenance management could be a complex subject if implementation and planning issues of the building facility are not handled properly. In this context, the current maintenance management method has affected the efficiency of the building facility management at Polytechnics. Many issues such as poor service delivery, inadequate finance, poor maintenance planning and maintenance backlogs were emerged due to the usage of conventional method application (paper-based form and unsystematic database). Therefore, this research is to review existing maintenance management practices, and subsequently develop a prototype system based on the stated problems related to the conventional method in improving the maintenance management processes. Literature review and semi-structured interview was carried out to achieve the objectives. Eight Polytechnics are selected based on major problems of using conventional method in the comparison to investigate the maintenance management practices in each Polytechnic. There are around 32 Polytechnics in Malaysia and almost are using conventional methods. The number is considered very big indicating that the use of modern Information and Communication Technology (ICT) is still very limited compared to other institutions of higher learning in Malaysia. The results revealed that the practice of maintenance management at Polytechnics needs to be improved and a computerised system was proposed based on the requirements of a maintenance management system identified through the case studies. The framework was encapsulated in a computer-based prototype system based on Microsoft Visual Basic.Net as a graphical user-interface while for the database design, the Microsoft Access is used to deploy the information for maintenance management processes. The computerised system was developed using Data Flow Diagram (DFD) and vi coding. Subsequently, the prototype system was tested by running it until the critical problems were fixed and its functional requirements work correctly. This system will help with the building diagnosis and decision making process approaches. It will assist staff in facilitating the maintenance identification, assessment, planning and execution in relation to building facility. In conclusion, the developed prototype system can improve the maintenance management practices effectiveness for building facility to provide high- quality building facility for safe and healthy environment.

Subjects/Keywords: TH3301-3411 Maintenance and repair

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ismail, Z. (2013). DMOSYS: defect monitoring system for building maintenance at polytechnic. (Masters Thesis). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/5456/

Chicago Manual of Style (16^th Edition):

Ismail, Zul-Atfi. “DMOSYS: defect monitoring system for building maintenance at polytechnic.” 2013. Masters Thesis, Universiti Tun Hussein Onn Malaysia. Accessed July 23, 2019. http://eprints.uthm.edu.my/5456/.

MLA Handbook (7^th Edition):

Ismail, Zul-Atfi. “DMOSYS: defect monitoring system for building maintenance at polytechnic.” 2013. Web. 23 Jul 2019.

Vancouver:

Ismail Z. DMOSYS: defect monitoring system for building maintenance at polytechnic. [Internet] [Masters thesis]. Universiti Tun Hussein Onn Malaysia; 2013. [cited 2019 Jul 23]. Available from: http://eprints.uthm.edu.my/5456/.

Council of Science Editors:

Ismail Z. DMOSYS: defect monitoring system for building maintenance at polytechnic. [Masters Thesis]. Universiti Tun Hussein Onn Malaysia; 2013. Available from: http://eprints.uthm.edu.my/5456/

23. Zuraidi , Siti Nor Fatimah. Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah.

Degree: Fakulti Kejuruteraan Awam dan Alam Sekitar, 2014, Universiti Tun Hussein Onn Malaysia

URL: http://eprints.uthm.edu.my/6331/

► Malaysia merupakan sebuah negara yang sedang pesat membangun. Arus pembangunan yang pesat ini terdapat bangunan yang penuh dengan kesan sejarah yang menarik. Hasil daripada penyelidikan,… (more)

▼ Malaysia merupakan sebuah negara yang sedang pesat membangun. Arus pembangunan yang pesat ini terdapat bangunan yang penuh dengan kesan sejarah yang menarik. Hasil daripada penyelidikan, didapati bahawa ada di antara bangunan bersejarah ini tidak dipulihara dengan baik malah ada yang telah dirobohkan kerana terdapat banyak kesan kecacatan yang berlaku dan keadaan seumpama ini telah mencacatkan keindahan dan keunikan rupa bentuknya. Kajian ini menggunakan kaedah soal selidik dan tinjauan tapak. Soal selidik diedarkan kepada 35 responden dan telah dikembalikan sebanyak 34 responden yang terdiri daripada pihak pengurusan, kontraktor, arkitek, juruukur bahan dan perunding. Data kajian dianalisis menggunakan Statistical Packages for Social Sciences (SPSS) dengan berpandukan statistik deskriptif dan frekuensi untuk mendapatkan nilai peratusan, min dan kekerapan. Hasil analisis objektif pertama telah mengenal pasti sebanyak 8 jenis kerosakan dan kecacatan yang sering berlaku pada elemen bangunan bersejarah iaitu bumbung, dinding, siling, lantai, pintu, tingkap, tangga dan tiang. Hasil análisis objektif kedua telah menemui sebanyak 13 punca kerosakan dan kecacatan iaitu kelemahan pada rekabentuk, mutu kerja rendah, kualiti bahan yang rendah, kelembapan, kecuaian, projek pembinaan berdekatan kawasan bangunan, serangan serangga perosak, pergerakan dalam tanah, kegagalan pada bahagian sambungan, ketidakstabilan struktur bangunan, ketidakseimbangan bahan binaan pada fasad bangunan, kehadiran garam yang terhasil daripada proses penghabluran dan pengecutan bahan binaan. Hasil daripada analisis, beberapa cadangan telah dirangkakan bagi kerja pemuliharaan struktur fabrik pada bangunan bersejarah untuk dijadikan sebagai rujukan dan garis panduan kepada pihak pengurusan, kontraktor, arkitek, juruukur bahan dan perunding dalam usaha untuk memulihara bangunan bersejarah. Diharapkan kajian ini akan diteruskan oleh penyelidik dalam mengkaji implikasi undang-undang dan garis panduan bagi kerja- kerja pemuliharaan bangunan bersejarah.

Subjects/Keywords: TH3301-3411 Maintenance and repair

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zuraidi , S. N. F. (2014). Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah. (Masters Thesis). Universiti Tun Hussein Onn Malaysia. Retrieved from http://eprints.uthm.edu.my/6331/

Chicago Manual of Style (16^th Edition):

Zuraidi , Siti Nor Fatimah. “Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah.” 2014. Masters Thesis, Universiti Tun Hussein Onn Malaysia. Accessed July 23, 2019. http://eprints.uthm.edu.my/6331/.

MLA Handbook (7^th Edition):

Zuraidi , Siti Nor Fatimah. “Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah.” 2014. Web. 23 Jul 2019.

Vancouver:

Zuraidi SNF. Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah. [Internet] [Masters thesis]. Universiti Tun Hussein Onn Malaysia; 2014. [cited 2019 Jul 23]. Available from: http://eprints.uthm.edu.my/6331/.

Council of Science Editors:

Zuraidi SNF. Model rangka kerja pemuliharaan struktur fabrik bagi bangunan bersejarah. [Masters Thesis]. Universiti Tun Hussein Onn Malaysia; 2014. Available from: http://eprints.uthm.edu.my/6331/

University of Alberta

24. Leung, Charles. Molecular basis of TopBP1 BRCT domain interactions in the DNA damage response.

Degree: PhD, Department of Biochemistry, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/jw827c22z

► Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication… (more)

▼ Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication stress, TopBP1 participates in a series of protein interactions to collectively activate the key Ser/Thr kinase, Ataxia telangiectasia and Rad3 related (ATR), and control the DNA replication checkpoint. These phosphorylation-dependent interactions are mediated by the numerous conserved BRCT domains within TopBP1. Our studies utilize X-ray crystallography in combination with other biochemical and biophysical techniques to elucidate the molecular basis underlying various TopBP1 BRCT-mediated interactions in DNA damage response signalling. Contrary to previous studies suggesting that the single BRCT6 domain of TopBP1 recognizes a phospho-peptide of the transcription factor, E2F1, and binds to poly(ADP-ribose) chains, the crystal structure of BRCT6 provides evidence that both the phospho-peptide binding pocket and PAR-binding motif are non-functional. Our studies of distinct phospho-peptide interactions involving the tandem BRCT7/8 and BRCT4/5 repeats of TopBP1 shed light on critical interactions required for activation of ATR and the DNA replication checkpoint. In addition, the mode of phospho-peptide recognition presented by these BRCT repeats uncover new and exciting perspectives in BRCT domain function that were previously unknown. Analysis of the structures of TopBP1 BRCT7/8 and in complex with a BACH1 phospho-peptide provides the first demonstration of pThr specificity and an uncharacteristic plasticity at the BRCT domain interface for canonical tandem BRCT domains. Our structural investigations of interactions between TopBP1 BRCT4/5 and a MDC1 phospho-peptide reveal a novel tandem BRCT domain packing arrangement, as well as an unexpected dimerization of two BRCT4/5 domains needed to stabilize interactions with a single phospho-peptide. Taken together, our studies of TopBP1 BRCT domain interactions provide molecular insights into crucial protein interactions involved in DNA replication checkpoint signalling and also highlight the extraordinary functional diversity of BRCT domains.

Subjects/Keywords: DNA repair; X-ray crystallography

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APA (6^th Edition):

Leung, C. (2011). Molecular basis of TopBP1 BRCT domain interactions in the DNA damage response. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/jw827c22z

Chicago Manual of Style (16^th Edition):

Leung, Charles. “Molecular basis of TopBP1 BRCT domain interactions in the DNA damage response.” 2011. Doctoral Dissertation, University of Alberta. Accessed July 23, 2019. https://era.library.ualberta.ca/files/jw827c22z.

MLA Handbook (7^th Edition):

Leung, Charles. “Molecular basis of TopBP1 BRCT domain interactions in the DNA damage response.” 2011. Web. 23 Jul 2019.

Vancouver:

Leung C. Molecular basis of TopBP1 BRCT domain interactions in the DNA damage response. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2019 Jul 23]. Available from: https://era.library.ualberta.ca/files/jw827c22z.

Council of Science Editors:

Leung C. Molecular basis of TopBP1 BRCT domain interactions in the DNA damage response. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/jw827c22z

25. Jarvis,Kimberly D. An Exploration of a Culture of Reintegration with Women Who Have Experienced Obstetrical Fistula Repair in Northern Ghana, West Africa.

Degree: PhD, Faculty of Nursing, 2016, University of Alberta

URL: https://era.library.ualberta.ca/files/ct435gd21c

► More than two million women in Asia and sub-Saharan Africa live with untreated obstetric fistula (OF). Factors contributing to and affecting the care of OF… (more)

▼ More than two million women in Asia and sub-Saharan Africa live with untreated obstetric fistula (OF). Factors contributing to and affecting the care of OF are embedded in the social determinants of health. A three-pronged approach to OF care has been suggested, including awareness, treatment, and social reintegration; however, women’s health organizations have argued that social reintegration is the most important aspect of care next to the surgery itself. The aim of this study was to explore a culture of reintegration for women who experience an OF repair in northern Ghana. A critical ethnography was employed, using a health equity/social justice lens to discern the meaning and point of view of participants about a culture of reintegration post-OF. Ninety-nine participants were recruited from 24 rural communities in northern Ghana using convenience, purposive and snowball sampling. Study participants included: • Women who had experienced an OF repair a minimum of three months prior to being interviewed. • Family members of women who had experienced an OF repair and were involved in their care pre- and post-OF repair, or post-OF repair only. Only those identified as family members of women interviewed were considered. • Health-care providers (HCPs) who cared for women who experienced an OF repair (i.e. nurses, doctors, traditional birth attendants, traditional healers). • Community stakeholders, those in leadership positions, or who provided service to the community, and were involved in OF care at the community, regional or national level (i.e. government officials, nongovernmental organizations, religious leaders, women leaders). Observation, field notes, personal reflections, semi-structured interviews, and the assessment of relevant public policy documents were methods utilized. Data was analysed according to Hammersley and Atkinson’s (2007) approach to ethnographic analysis. Nvivo 10.0 software was used for data management. Ethics approval was received from the Human Research Ethics Review Board at the University of Alberta, Canada and at the Navrongo Health Research Center, Institutional Review Board, Ghana. Findings suggest that reintegration does not occur in isolation of the other two components of care; awareness and treatment. Although most families are excited to have their family member return home post-OF, women, families, and communities do express feelings of uncertainty. Women, their families, HCPs, and community stakeholders identify that OF health teaching, skills training, community follow-up, community awareness, family support, and existing health policies are important factors in the success of reintegration. Despite this fact, participants describe the economic, societal, systemic and cultural constraints to a woman’s ability to reintegrate, and offer solutions for change. Additionally, family members describe the impact OF had on them, drawing attention to the need for formal care-giving supports in light of the changing role of the family in Ghanaian society. Research findings provide…

Subjects/Keywords: Obstetrical Fistula Repair; Ghana; Reintegration

11 more images…

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APA (6^th Edition):

D, J. (2016). An Exploration of a Culture of Reintegration with Women Who Have Experienced Obstetrical Fistula Repair in Northern Ghana, West Africa. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/ct435gd21c

Chicago Manual of Style (16^th Edition):

D, Jarvis,Kimberly. “An Exploration of a Culture of Reintegration with Women Who Have Experienced Obstetrical Fistula Repair in Northern Ghana, West Africa.” 2016. Doctoral Dissertation, University of Alberta. Accessed July 23, 2019. https://era.library.ualberta.ca/files/ct435gd21c.

MLA Handbook (7^th Edition):

D, Jarvis,Kimberly. “An Exploration of a Culture of Reintegration with Women Who Have Experienced Obstetrical Fistula Repair in Northern Ghana, West Africa.” 2016. Web. 23 Jul 2019.

Vancouver:

D J. An Exploration of a Culture of Reintegration with Women Who Have Experienced Obstetrical Fistula Repair in Northern Ghana, West Africa. [Internet] [Doctoral dissertation]. University of Alberta; 2016. [cited 2019 Jul 23]. Available from: https://era.library.ualberta.ca/files/ct435gd21c.

Council of Science Editors:

D J. An Exploration of a Culture of Reintegration with Women Who Have Experienced Obstetrical Fistula Repair in Northern Ghana, West Africa. [Doctoral Dissertation]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/ct435gd21c

Texas A&M University

26. Shao, Shuo. Fundamental Limits of Exact-Repair Regenerating Codes.

Degree: 2017, Texas A&M University

URL: http://hdl.handle.net/1969.1/161617

► Understanding the fundamental limits of communication systems involves both constructing efficient coding schemes as well as proving mathematically that certain performance is impossible to achieve;… (more)

▼ Understanding the fundamental limits of communication systems involves both constructing efficient coding schemes as well as proving mathematically that certain performance is impossible to achieve; the latter is known as the converse problem in information theory. This thesis focused on the converse problems for complex information systems such as self-repair distributed storage and coded caching systems, and our goal was to establish tight converse results for such systems by exploiting problem-specific combinatorial structures. The main part of this thesis dealt with exact-repair regenerating codes, which were first proposed by Dimakis et al. in 2010. In particular, we considered two extensions of the original setting of Dimakis et al., namely 1) multilevel diversity coding with regeneration and 2) secure exact-repair regenerating codes. For the problem of multilevel diversity coding with regeneration, we showed, via the proposed combinatorial approach, that the natural separate encoding strategy can achieve the optimal tradeoff between the normalized storage capacity and repair bandwidth at the minimum-bandwidth rate (MBR) point. This settled a conjecture by Tian and Liu in 2015. For the problem of secure exact-repair regenerating codes, all known results from the literature showed that the achievable tradeoff regions between the normalized storage capacity and repair bandwidth have a single corner point, achieved by a scheme proposed by Shah, Rashmi and Kumar (the SRK point). Since the achievable tradeoff regions of the exact-repair regenerating code problem without any secrecy constraints were known to have multiple corner points in general, these existing results suggested a phase-change-like behavior, i.e., enforcing a secrecy constraint immediately reduces the tradeoff region to one with a single corner point. In our work, we first showed that when the secrecy parameter is sufficiently large, the SRK point is indeed the only corner point of the tradeoff region. However, when the secrecy parameter is small, we showed that the tradeoff region can, in fact, have multiple corner points. In particular, we established a precise characterization of the tradeoff region for a particular problem instance, which has exactly two corner points. Thus, a smooth transition, instead of a phase-change-type of transition, should be expected as the secrecy constraint is gradually strengthened. Advisors/Committee Members: Liu, Tie (advisor), Chamberland-Tremblay, Jean-Francois (committee member), Qian, Xiaoning (committee member), Anshelevich, Michael (committee member).

Subjects/Keywords: exact-repair regenerating codes

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APA (6^th Edition):

Shao, S. (2017). Fundamental Limits of Exact-Repair Regenerating Codes. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/161617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shao, Shuo. “Fundamental Limits of Exact-Repair Regenerating Codes.” 2017. Thesis, Texas A&M University. Accessed July 23, 2019. http://hdl.handle.net/1969.1/161617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shao, Shuo. “Fundamental Limits of Exact-Repair Regenerating Codes.” 2017. Web. 23 Jul 2019.

Vancouver:

Shao S. Fundamental Limits of Exact-Repair Regenerating Codes. [Internet] [Thesis]. Texas A&M University; 2017. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1969.1/161617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shao S. Fundamental Limits of Exact-Repair Regenerating Codes. [Thesis]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/161617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

27. Alexander, Christopher Richard. Development of a composite repair system for reinforcing offshore risers.

Degree: 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2534

► A research program was conducted to investigate the application of composite materials in repairing corroded offshore risers, leading to the development of an optimized repair… (more)

▼ A research program was conducted to investigate the application of composite materials in repairing corroded offshore risers, leading to the development of an optimized repair using a hybrid carbon/E-glass system. The objective of this research program was to investigate the feasibility of extending onshore composite repair techniques to offshore risers by developing integrated analytical and experimental methods. The study considered loads typical for offshore risers including internal pressure, tension, and bending. To fulfill this objective efforts included a state of the art assessment of current composite repair technology, designing a carbon-based composite repair system optimized by numerical simulation with prototype testing, and providing guidelines for industry in repairing and reinforcing offshore risers using composite materials. Research efforts integrated numerical modeling, as well as full-scale testing that included four composite repair manufacturers to assess the current state of the art on pipe samples with simulated corrosion reinforced with composite materials. Analysis and testing were also performed on the optimized carbon/E-glass system. The results of this program demonstrated that composite materials are a viable means for repairing corroded offshore steel risers as adequate reinforcement ensures that the steel risers are not loaded beyond acceptable design limits. For corroded risers, the results demonstrated through analysis and full-scale testing efforts that properly designed composite repair systems can provide adequate structural reinforcement to ensure that excessive strains are not induced in the steel when subjected to internal pressure, axial tension, and bending design loads. This was verified experimentally using strain gages placed beneath the composite repair. This program is the first of its kind and is thought to contribute significantly to the future of offshore riser repairs. It is likely that the findings of this program will foster future investigations involving operators by integrating their insights regarding the need for composite repair based on emerging technology. One of the most significant contributions to the existing body of work is the use of limit analysis in developing design limits for the repair of steel pipes using composite materials. Advisors/Committee Members: Hogan, Harry (advisor), Ochoa, Ozden (advisor), Keating, Peter (committee member), Lalk, Thomas (committee member).

Subjects/Keywords: offshore; riser; repair; composite

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APA (6^th Edition):

Alexander, C. R. (2009). Development of a composite repair system for reinforcing offshore risers. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alexander, Christopher Richard. “Development of a composite repair system for reinforcing offshore risers.” 2009. Thesis, Texas A&M University. Accessed July 23, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-2534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alexander, Christopher Richard. “Development of a composite repair system for reinforcing offshore risers.” 2009. Web. 23 Jul 2019.

Vancouver:

Alexander CR. Development of a composite repair system for reinforcing offshore risers. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alexander CR. Development of a composite repair system for reinforcing offshore risers. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

28. Mokarram-Dorri, Nassir. Modulating immune response inside biomaterial-based nerve conduits to stimulate endogenous peripheral nerve regeneration.

Degree: PhD, Materials Science and Engineering, 2015, Georgia Tech

URL: http://hdl.handle.net/1853/54860

► Injuries to the peripheral nervous system (PNS) are major and common source of disability, impairing the ability to move muscles and/or feel normal sensations, or… (more)

▼ Injuries to the peripheral nervous system (PNS) are major and common source of disability, impairing the ability to move muscles and/or feel normal sensations, or resulting in painful neuropathies. Annually traumatic nerve injuries resulting from collisions, gunshot wounds, fractures, motor vehicle accidents, lacerations, and other forms of penetrating trauma, affected more than 250,000 patients just in the U.S. The clinical gold standard to bridge long non-healing nerve gaps is to use a nerve autograft- typically the patient’s own sural nerve. However, autografts are not ideal because of the need for secondary surgery to ‘source’ the nerve, loss of function at the donor site, lack of appropriate source nerve in diabetic patients, neuroma formation, and the need for multiple graft segments. Despite our best efforts, finding alternative ‘nerve bridges’ for peripheral nerve repair remains challenging – of the four nerve ‘tubes’ FDA approved for use in the clinic, none is typically used to bridge gaps longer than 10 mm due to poor outcomes. Hence, there is a compelling need to design alternatives that match or exceed the performance of autografts across critically sized nerve gaps. Here we demonstrate that early modulation of innate immune response at the site of peripheral nerve injury inside biomaterials-based conduit can favorably bias the endogenous regenerative potential after injury that obviates the need for the downstream modulation of multiple factors and has significant implications for the treatment of long peripheral nerve gaps. Moreover, our study strongly suggests that more than the extent of macrophage presence, their specific phenotype at the site of injury influence the regenerative outcomes. This research will advance our knowledge regarding peripheral nerve regeneration, and help developing technologies that are likely to improve clinical outcomes after peripheral nerve injury. The significant results presented here are complementary to a growing body of evidence showing the direct correlation between macrophage phenotype and the regeneration outcome of injured tissues. Advisors/Committee Members: Bellamkonda, Ravi V. (advisor), Botchwey, Edward A. (committee member), English, Arthur W. (committee member), García, Andrés J. (committee member), Milam, Valeria (committee member).

Subjects/Keywords: Nerve repair; Immunomodulation; Macrophage

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mokarram-Dorri, N. (2015). Modulating immune response inside biomaterial-based nerve conduits to stimulate endogenous peripheral nerve regeneration. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/54860

Chicago Manual of Style (16^th Edition):

Mokarram-Dorri, Nassir. “Modulating immune response inside biomaterial-based nerve conduits to stimulate endogenous peripheral nerve regeneration.” 2015. Doctoral Dissertation, Georgia Tech. Accessed July 23, 2019. http://hdl.handle.net/1853/54860.

MLA Handbook (7^th Edition):

Mokarram-Dorri, Nassir. “Modulating immune response inside biomaterial-based nerve conduits to stimulate endogenous peripheral nerve regeneration.” 2015. Web. 23 Jul 2019.

Vancouver:

Mokarram-Dorri N. Modulating immune response inside biomaterial-based nerve conduits to stimulate endogenous peripheral nerve regeneration. [Internet] [Doctoral dissertation]. Georgia Tech; 2015. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1853/54860.

Council of Science Editors:

Mokarram-Dorri N. Modulating immune response inside biomaterial-based nerve conduits to stimulate endogenous peripheral nerve regeneration. [Doctoral Dissertation]. Georgia Tech; 2015. Available from: http://hdl.handle.net/1853/54860

University of Zambia

29. Makawa, Daniel. To determine the short-term outcome of combined Ventriculoperitoneal Shunting and Myelomeningocele repair at the University Teaching Hospital .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/980

► Background and Objective: There is paucity of data on the outcome of combined VPS insertion and myelomeningocoele repair, and whether this will reduce morbidity and… (more)

Subjects/Keywords: Ventriculoperitoneal Shunting; Myelomeningocele Repair

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Makawa, D. (2012). To determine the short-term outcome of combined Ventriculoperitoneal Shunting and Myelomeningocele repair at the University Teaching Hospital . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Makawa, Daniel. “To determine the short-term outcome of combined Ventriculoperitoneal Shunting and Myelomeningocele repair at the University Teaching Hospital .” 2012. Thesis, University of Zambia. Accessed July 23, 2019. http://hdl.handle.net/123456789/980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Makawa, Daniel. “To determine the short-term outcome of combined Ventriculoperitoneal Shunting and Myelomeningocele repair at the University Teaching Hospital .” 2012. Web. 23 Jul 2019.

Vancouver:

Makawa D. To determine the short-term outcome of combined Ventriculoperitoneal Shunting and Myelomeningocele repair at the University Teaching Hospital . [Internet] [Thesis]. University of Zambia; 2012. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/123456789/980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Makawa D. To determine the short-term outcome of combined Ventriculoperitoneal Shunting and Myelomeningocele repair at the University Teaching Hospital . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

30. Cousins, Fiona Lyndsay. Regulation of endometrial regeneration : mechanisms contributing to repair and restoration of tissue integrity following menses.

Degree: PhD, 2014, University of Edinburgh

URL: http://hdl.handle.net/1842/10055

► The human endometrium is a dynamic, multi-cellular tissue that lines the inside of the uterine cavity. During a woman’s reproductive lifespan the endometrium is subjected… (more)

▼ The human endometrium is a dynamic, multi-cellular tissue that lines the inside of the uterine cavity. During a woman’s reproductive lifespan the endometrium is subjected to cyclical episodes of proliferation, angiogenesis, differentiation/decidualisation, shedding (menstruation), repair and regeneration in response to fluctuating levels of oestrogen and progesterone secreted by the ovaries. The endometrium displays unparalleled, tightly regulated, tissue remodelling resulting in a healed, scar-free tissue following menses or parturition. Mechanisms responsible for initiation of menses have been well documented: following progesterone withdrawal there is an increase in inflammatory mediators, focal hypoxia and induction and activation of matrix-degrading enzymes. In contrast, the molecular and cellular changes responsible for rapid, regulated, tissue repair at a time when oestrogen and progesterone are low are poorly understood. Histological studies using human menstrual phase endometrium have revealed that tissue destruction and shedding occur in close proximity to re-epithelialisation/repair. It has been proposed that re-epithelialisation involves proliferation of glandular epithelial cells in the remaining basal compartment; there is also evidence for a contribution from the underlying stroma. A role for androgens in the regulation of apoptosis of endometrial stromal cells has been proposed but the impact of androgens on tissue repair has not been investigated. Studies using human xenografts and primates have been used to model some aspects of the impact of progesterone withdrawal but simultaneous shedding (menses) and repair have not been modelled in mice; the species of choice for translational biomedical research. In the course of the studies described in this thesis, the following aims have been addressed: 1. To establish a model of menses in the mouse which mimics menses in women, namely; simultaneous breakdown and repair, overt menstruation, immune cell influx, tissue necrosis and re-epithelialisation. 2. To use this model to determine if the stromal cell compartment contributes to endometrial repair. 3. To examine the impact of androgens on the regulation of menses (shedding) and repair. An informative mouse model of endometrial breakdown that was characterised by overt menses, as well as rapid repair, was developed. Immunohistological evidence for extensive tissue remodelling including active angiogenesis, transient hypoxia, epithelial cell-specific proliferation and re-epithelialisation were obtained by examining uterine tissues recovered during an “early window of breakdown and repair” (4 to 24 hours after progesterone withdrawal). Novel data included identification of stromal cells that expressed epithelial cell markers, close to the luminal surface following endometrial shedding, suggesting a role for mesenchymal to epithelial transition (MET) in re-epithelialisation of the endometrium. In support of this idea, array and qRTPCR analyses revealed dynamic changes in expression of mRNAs encoded by genes…

Subjects/Keywords: 618.1; endometrium; repair; regeneration; menses

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cousins, F. L. (2014). Regulation of endometrial regeneration : mechanisms contributing to repair and restoration of tissue integrity following menses. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/10055

Chicago Manual of Style (16^th Edition):

Cousins, Fiona Lyndsay. “Regulation of endometrial regeneration : mechanisms contributing to repair and restoration of tissue integrity following menses.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed July 23, 2019. http://hdl.handle.net/1842/10055.

MLA Handbook (7^th Edition):

Cousins, Fiona Lyndsay. “Regulation of endometrial regeneration : mechanisms contributing to repair and restoration of tissue integrity following menses.” 2014. Web. 23 Jul 2019.

Vancouver:

Cousins FL. Regulation of endometrial regeneration : mechanisms contributing to repair and restoration of tissue integrity following menses. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1842/10055.

Council of Science Editors:

Cousins FL. Regulation of endometrial regeneration : mechanisms contributing to repair and restoration of tissue integrity following menses. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/10055

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Open Access Theses and Dissertations