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You searched for subject:(Remodeling enzyme). One record found.

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1. Sabariragian, Jayaraj. Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -.

Degree: Biochemistry, 2011, Bharathidasan University

Acute lung injury (ALI) or its most severe form, acute respiratory distress syndrome (ARDS) is a clinically devastating and life threatening syndrome, which is caused mainly by dysfunctioning of pulmonary surfactants. Despite advances made in understanding the intricate molecular pathogenesis of ARDS for the past 3 decades, the mortality associated with ARDS still remains at ~ 40-50%. Lipopolysaccharide (LPS), is an endotoxin, a well known inducer compound for ALI/ARDS. In order to understand its pathogenic mechanism, alteration of phospholipid metabolism in pulmonary system in the current work is well studied. Previous reports have focussed mainly on phosphatidylcholine (PC), especially dipalmitoyl-PC (DPPC) and phosphatidylglycerol (PG) but the regulation of phospholipids in lungs during endotoxemia have not been elucidated. The immunological effect of LPS is also well documented in spleen and thymus; however impact on lipids particularly phospholipid metabolism is yet to be studied. Hence the present study was undertaken to investigate the role of phospholipids in lung, spleen and thymus during ARDS. Our objective was first initiated by in vitro metabolic labelling studies with [32P]orthophosphate followed by in vivo experiments. Labelling studies revealed significant impairments in PC and PG of lung, spleen and PC in thymus. The fatty acid (FA) analysis also showed marked alterations. To further understand the PL metabolism we have developed an animal model for ALI/ARDS [Sabarirajan et al., 2010]. Rats were divided into four groups. Group I, Control animals (24 h saline treated); Group II, III and IV were given LPS (10 mg/kg body wt.) intraperitoneally and sacrificed after 6, 12 and 24 h respectively. We observed reduced phospholipid content especially PC, PG in lung and major PL in spleen and thymus. FA distribution of individual PL shows an overall increase in unsaturated/saturated FA in lung, spleen and thymus. This might be due to the sensitive/adaptive response of the organ.

Bibliography p.123-141

Advisors/Committee Members: Vasanthi Nachiappan.

Subjects/Keywords: Fatty acids; ALI/ARDS; LPS; Lung; Spleen; Thymus; Phospholipid; Remodeling enzyme; Biochemistry

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APA (6th Edition):

Sabariragian, J. (2011). Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -. (Thesis). Bharathidasan University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/9457

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Sabariragian, Jayaraj. “Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -.” 2011. Thesis, Bharathidasan University. Accessed November 11, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/9457.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Sabariragian, Jayaraj. “Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -.” 2011. Web. 11 Nov 2019.

Vancouver:

Sabariragian J. Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -. [Internet] [Thesis]. Bharathidasan University; 2011. [cited 2019 Nov 11]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/9457.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sabariragian J. Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -. [Thesis]. Bharathidasan University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/9457

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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