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You searched for subject:(Remodeling enzyme). Showing records 1 – 2 of 2 total matches.

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1. Sabariragian, Jayaraj. Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -.

Degree: Biochemistry, 2011, Bharathidasan University

Acute lung injury (ALI) or its most severe form, acute respiratory distress syndrome (ARDS) is a clinically devastating and life threatening syndrome, which is caused mainly by dysfunctioning of pulmonary surfactants. Despite advances made in understanding the intricate molecular pathogenesis of ARDS for the past 3 decades, the mortality associated with ARDS still remains at ~ 40-50%. Lipopolysaccharide (LPS), is an endotoxin, a well known inducer compound for ALI/ARDS. In order to understand its pathogenic mechanism, alteration of phospholipid metabolism in pulmonary system in the current work is well studied. Previous reports have focussed mainly on phosphatidylcholine (PC), especially dipalmitoyl-PC (DPPC) and phosphatidylglycerol (PG) but the regulation of phospholipids in lungs during endotoxemia have not been elucidated. The immunological effect of LPS is also well documented in spleen and thymus; however impact on lipids particularly phospholipid metabolism is yet to be studied. Hence the present study was undertaken to investigate the role of phospholipids in lung, spleen and thymus during ARDS. Our objective was first initiated by in vitro metabolic labelling studies with [32P]orthophosphate followed by in vivo experiments. Labelling studies revealed significant impairments in PC and PG of lung, spleen and PC in thymus. The fatty acid (FA) analysis also showed marked alterations. To further understand the PL metabolism we have developed an animal model for ALI/ARDS [Sabarirajan et al., 2010]. Rats were divided into four groups. Group I, Control animals (24 h saline treated); Group II, III and IV were given LPS (10 mg/kg body wt.) intraperitoneally and sacrificed after 6, 12 and 24 h respectively. We observed reduced phospholipid content especially PC, PG in lung and major PL in spleen and thymus. FA distribution of individual PL shows an overall increase in unsaturated/saturated FA in lung, spleen and thymus. This might be due to the sensitive/adaptive response of the organ.

Bibliography p.123-141

Advisors/Committee Members: Vasanthi Nachiappan.

Subjects/Keywords: Fatty acids; ALI/ARDS; LPS; Lung; Spleen; Thymus; Phospholipid; Remodeling enzyme; Biochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sabariragian, J. (2011). Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -. (Thesis). Bharathidasan University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/9457

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Sabariragian, Jayaraj. “Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -.” 2011. Thesis, Bharathidasan University. Accessed October 23, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/9457.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Sabariragian, Jayaraj. “Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -.” 2011. Web. 23 Oct 2019.

Vancouver:

Sabariragian J. Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -. [Internet] [Thesis]. Bharathidasan University; 2011. [cited 2019 Oct 23]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/9457.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sabariragian J. Impaired phosphoglyceride metabolism in lung, spleen and thymus during lipopolysaccaride - induced acute respiratory distress syndrome in male wistar rats; -. [Thesis]. Bharathidasan University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/9457

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Rita de Cássia Marqueti. Efeitos dos esteróides anabólicos-androgênicos (EAA) associados ao exercício de carga no remodelamento do tendão de Aquiles em ratos.

Degree: 2005, Universidade Federal de São Carlos

O uso indiscriminado de esteróides anabólicos-androgênicos (EAA) tem sido descrito em diversas situações como causadores de patologias em tendão. O objetivo deste trabalho foi avaliar o remodelamento de tendão em ratos tratados com EAA associando exercício de alta intensidade. Os animais foram divididos em quatro grupos: Grupo I (GI) (sedentário); GII (não treinado, mas recebia injeção de EAA); GIII (treinado sem EAA) and GIV (treinado e também com injeção de EAA). O treinamento foi constituído por saltos em meio líquido à 32C: 4 séries de 10 saltos cada, com intervalo de 30 segundos entre as séries, em 5 dias da semana, durante 6 semanas, com carga variando de 50 -70 % da massa corporal do animal. Os EAA (Decadurabolin e Durateston 5 mg/kg) foram injetados via subcutânea atravessando o tríceps sural, na pata direita posterior do animal. As análises morfológicas dos cortes de tendões mostraram que no grupo somente com administração de EAA a camada mais externa que reveste o tendão ficou mais espessa apresentando também uma mistura de fibras e fibrose. No grupo treinado, visualiza-se um grande número de fibroblastos no epitendão. Nos animais que fizeram associação de EAA e exercício foi encontrado infiltrado inflamatório na região que recobre o tendão, bem como, áreas com fibrose. O protocolo de treinamento aumenta a atividade de MMPs (metalopeptidases) enquanto o tratamento com EAA induz a uma significante diminuição na atividade de MMPs. Em ambos os grupos que receberam injeção de EAA (GII e GIV), observou-se aumento na concentração da ECA (enzima conversora de angiotensina) no soro dos animais. Em conclusão o tratamento com EAA pode induzir severas lesões no tendão, principalmente quando associado ao exercício, alterando a quantidade de MMPs e atrapalhando o remodelamento do tecido.

The indiscriminate use of anabolic-androgenic steroids (AAS) is very spread out in the sportive world. The AAS have been described to induce tendon pathology in some situations. The aim of this work was to evaluate the tendon remodeling in rats treated with AAS associated with physical exercise. Male Wistar rats were divided into four groups: Group I (GI) (sedentary); G II (not trained, but injected with AAS); G III (trained without AAS) and G IV (both trained and injected with AAS). The trained groups have carried out jumps in water at 32C: 4 series of 10 jumps each, with a 30-second interval among series, for 6 weeks, with 50-70% overload of the animal corporal mass. The AAS (Decadurabolin and Durateston - 5mg/Kg) were injected via subcutaneous intersect the triceps sural on the posterior right paw. Morphological analyses of the excised tendons showed that in the group with AAS, the most external layer that covers the tendon was thicker. Can be a mix interspersed fibers and fibrotic tissue next to the epitendon. In the trained group, a greater number of young fibroblasts in the region that covers the tendon was observed. In the group with association of the AAS and exercise an inflammatory infiltrate was found in the region that…

Advisors/Committee Members: Heloísa Sobreiro Selistre de Araujo.

Subjects/Keywords: FISIOLOGIA; Metalopeptidases de matrizes; Tendão de Aquiles; Esteróides anabólicos; Medicina experimental - rato; Remodeling; Metallopeptidases; Angiotensin converging enzyme; Androgenic-anabolic steroids; Tendon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Marqueti, R. d. C. (2005). Efeitos dos esteróides anabólicos-androgênicos (EAA) associados ao exercício de carga no remodelamento do tendão de Aquiles em ratos. (Thesis). Universidade Federal de São Carlos. Retrieved from http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Marqueti, Rita de Cássia. “Efeitos dos esteróides anabólicos-androgênicos (EAA) associados ao exercício de carga no remodelamento do tendão de Aquiles em ratos.” 2005. Thesis, Universidade Federal de São Carlos. Accessed October 23, 2019. http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Marqueti, Rita de Cássia. “Efeitos dos esteróides anabólicos-androgênicos (EAA) associados ao exercício de carga no remodelamento do tendão de Aquiles em ratos.” 2005. Web. 23 Oct 2019.

Vancouver:

Marqueti RdC. Efeitos dos esteróides anabólicos-androgênicos (EAA) associados ao exercício de carga no remodelamento do tendão de Aquiles em ratos. [Internet] [Thesis]. Universidade Federal de São Carlos; 2005. [cited 2019 Oct 23]. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marqueti RdC. Efeitos dos esteróides anabólicos-androgênicos (EAA) associados ao exercício de carga no remodelamento do tendão de Aquiles em ratos. [Thesis]. Universidade Federal de São Carlos; 2005. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.