You searched for subject:(Recurrence).
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University of Alberta
1.
Wu, Xuan.
Analysis of risk factors for Tuberculosis Recurrence using a
population-based TB/HIV integrated surveillance database in Chiang
Rai, Thailand.
Degree: MS, Public Health Sciences, 2010, University of Alberta
URL: https://era.library.ualberta.ca/files/6m311p651 
► TB recurrence is defined as a new episode of bacteriologically positive TB in a patient previously declared “successfully completed treatment.” Our study objective was to…
(more)
▼ TB recurrence is defined as a new episode of
bacteriologically positive TB in a patient previously declared
“successfully completed treatment.” Our study objective was to
identify risk factors of recurrence among HIV-infected and
HIV-uninfected TB patients. Based on a population-based TB/HIV
surveillance database of Chiang Rai Province, Thailand, a
retrospective cohort of TB patients with successful completions of
treatment between 1997 and 2008 was constructed. Poisson regression
was used to model independent effects of risk factors. TB
recurrence rates were 5.4/1,000 PYs and 9.7/1,000 PYs for
HIV-uninfected and infected TB patients, respectively. We
identified that among HIV-uninfected patients, older age, being
hilltribe, being prisoners, were at higher risk of recurrence.
While among HIV-infected patients, younger age, being male, and
having been cured from initial episode were associated with higher
recurrence rates. Targeted, practical preventive and treatment
strategies for those patients need to be implemented to lower the
TB recurrence rates.
Subjects/Keywords: risk factors; recurrence rate; Tuberculosis recurrence; HIV
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APA (6th Edition):
Wu, X. (2010). Analysis of risk factors for Tuberculosis Recurrence using a
population-based TB/HIV integrated surveillance database in Chiang
Rai, Thailand. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/6m311p651
Chicago Manual of Style (16th Edition):
Wu, Xuan. “Analysis of risk factors for Tuberculosis Recurrence using a
population-based TB/HIV integrated surveillance database in Chiang
Rai, Thailand.” 2010. Masters Thesis, University of Alberta. Accessed February 27, 2021.
https://era.library.ualberta.ca/files/6m311p651.
MLA Handbook (7th Edition):
Wu, Xuan. “Analysis of risk factors for Tuberculosis Recurrence using a
population-based TB/HIV integrated surveillance database in Chiang
Rai, Thailand.” 2010. Web. 27 Feb 2021.
Vancouver:
Wu X. Analysis of risk factors for Tuberculosis Recurrence using a
population-based TB/HIV integrated surveillance database in Chiang
Rai, Thailand. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2021 Feb 27].
Available from: https://era.library.ualberta.ca/files/6m311p651.
Council of Science Editors:
Wu X. Analysis of risk factors for Tuberculosis Recurrence using a
population-based TB/HIV integrated surveillance database in Chiang
Rai, Thailand. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/6m311p651
University of Saskatchewan
2.
Groot, Gary.
Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin.
Degree: 2011, University of Saskatchewan
URL: http://hdl.handle.net/10388/etd-07212011-140147
► Introduction Controversy continues over the extent of surgical resection margin required to minimize the risk of local recurrence (LR) in breast conserving therapy (BCT) for…
(more)
▼ Introduction
Controversy continues over the extent of surgical resection margin required to minimize the risk of local
recurrence (LR) in breast conserving therapy (BCT) for stage I and II breast cancer. This thesis explores whether or not a narrow (less than or equal to 2 mm) but negative resection margin in BCT for stage I and II breast cancer affects LR. Methodology
To address the question, all patients registered at the Saskatoon Cancer Center between January 1, 1991 and December 31, 2000 with a diagnosis of stage I or II invasive duct carcinoma of the breast treated with BCT were examined. All charts and pathology reports were reviewed with a review of the pathology for all cases where the resection margin was unclear in the original report. Other factors know or thought to effect LR (age, radiation boost, grade, extensive duct carcinoma in situ, ER/PR receptor status, tumor size, and systemic adjuvant therapy) were considered in the statistical analysis. Results
Amongst the 200 narrow margin cases 19 LR were detected (19/200=9.5%) while 52 LR were detected in the 491 wide margin cases (52/491=10.6%). This difference was not statistically significant.
Conclusions
A narrow (less than or equal to 2 mm) surgical resection margin does not result in an increase in local
recurrence compared to a surgical resection margin greater than 2 mm in breast conserving therapy for early stage duct carcinoma and does not warrant re-excision.
Advisors/Committee Members: Pahwa, Punum, Muhajarine, Nazeem, Leong, Wey, Rees, Henny, Thorpe, Lilian, Decoteau, John.
Subjects/Keywords: Local recurrence; Breast neoplasm
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APA (6th Edition):
Groot, G. (2011). Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/etd-07212011-140147
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Groot, Gary. “Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin.” 2011. Thesis, University of Saskatchewan. Accessed February 27, 2021.
http://hdl.handle.net/10388/etd-07212011-140147.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Groot, Gary. “Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin.” 2011. Web. 27 Feb 2021.
Vancouver:
Groot G. Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin. [Internet] [Thesis]. University of Saskatchewan; 2011. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10388/etd-07212011-140147.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Groot G. Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin. [Thesis]. University of Saskatchewan; 2011. Available from: http://hdl.handle.net/10388/etd-07212011-140147
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
강, 기관.
conventional cytology is not beneficial for prediciting peritoneal recurrence after curative surgery for gastric cancer.
Degree: 2015, Ajou University
URL: http://repository.ajou.ac.kr/handle/201003/11846
;
http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018789
► Purpose: The role of peritoneal washing cytology in determining further treatment strategies after gastric cancer surgery is still unclear. One reason for this is that…
(more)
▼ Purpose: The role of peritoneal washing cytology in determining further treatment strategies after gastric cancer surgery is still unclear. One reason for this is that optimal procedures to increase the accuracy of predicting peritoneal metastasis have not been established. The aim of this study was to evaluate the efficacy of cytology using samples harvested from 2 different abdominal cavity sites during gastric cancer surgery.
Materials and Methods: We prospectively recruited 110 patients who were clinically diagnosed with locally advanced gastric cancer (higher than cT1 stage disease). Peritoneal washing fluids were collected from the Douglas pouch and the subphrenic area. Patients were prospectively followed up for 2 years to determine the rates of recurrence and survival.
Results: Thirty-three patients dropped out of the study for several reasons, and 75 patients were finally included in the analysis. Seven patients (9.3%) showed positive cytology, of whom, 3 patients showed peritoneal recurrence. Tumor size was the only factor associated with positive cytology (P = 0.043). The accuracy and specificity of cytology for predicting peritoneal recurrence were 90.1% and 94.2%, respectively, whereas the sensitivity was 50.1%. The survival rate did not differ between patients with positive and those with negative cytology (P = 0.081).
Conclusions: Peritoneal washing cytology was not able to predict peritoneal recurrence or survival in gastric cancer patients. Thus, conventional cytology during gastric cancer surgery seems to be a superfluous procedure
TABLE OF CONTENTS
ABSTRACT ⅰ
TABLE OF CONTENTS ⅲ
LIST OF FIGURES ⅳ
LIST OF TABLES v
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 2
Ⅲ. RESULTS 7
Ⅳ.DISCUSSION 14
REFERENCES 18
Master
Advisors/Committee Members: 대학원 의학과, 201124108, 강, 기관.
Subjects/Keywords: Gastric Neoplasm; Cytology; Peritoneal recurrence
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APA (6th Edition):
강, . (2015). conventional cytology is not beneficial for prediciting peritoneal recurrence after curative surgery for gastric cancer. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/11846 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018789
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
강, 기관. “conventional cytology is not beneficial for prediciting peritoneal recurrence after curative surgery for gastric cancer.” 2015. Thesis, Ajou University. Accessed February 27, 2021.
http://repository.ajou.ac.kr/handle/201003/11846 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018789.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
강, 기관. “conventional cytology is not beneficial for prediciting peritoneal recurrence after curative surgery for gastric cancer.” 2015. Web. 27 Feb 2021.
Vancouver:
강 . conventional cytology is not beneficial for prediciting peritoneal recurrence after curative surgery for gastric cancer. [Internet] [Thesis]. Ajou University; 2015. [cited 2021 Feb 27].
Available from: http://repository.ajou.ac.kr/handle/201003/11846 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018789.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
강 . conventional cytology is not beneficial for prediciting peritoneal recurrence after curative surgery for gastric cancer. [Thesis]. Ajou University; 2015. Available from: http://repository.ajou.ac.kr/handle/201003/11846 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018789
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
4.
Wendler, Astrid Svenja.
The Evolution of Glioblastoma: A Single Case Study.
Degree: PhD, 2019, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/291699
► Glioblastoma multiforme (GBM) is the most malignant and common primary brain cancer in adults, with a 2.5-year survival of only ~8%. In this single case…
(more)
▼ Glioblastoma multiforme (GBM) is the most malignant and common primary brain cancer in adults, with a 2.5-year survival of only ~8%. In this single case study we have analysed the development of a primary GBM over four years. We performed WGS and RNAseq on three, spatially distinct samples of the treatment naïve primary tumour, the first recurrence and the fatal second recurrence. We observed a massive increase in mutations from the first to the second recurrence, showing predominantly C>T and A>G transitions, which is a pattern typical of TMZ treatment. The fact that the hypermutation did not appear until the second recurrence raises questions about the mechanism of hypermutation. The therapeutic apoptotic action of TMZ relies on the function of the mismatch repair (MMR) pathway. In the second recurrence we observed disruptive mutations of MSH6, MSH2, PMS2 and MLH1 all of which are crucial to the MMR pathway. The pattern of mutations of these genes varied between the samples taken from the second recurrence, however, all three samples showed hypermutation. This suggests that the hypermutation observed after TMZ treatment only occurs if the MMR is damaged, but that this damage does not need to be at a specific locus.
Using the CRISPR-Cas9 technology we explored the impact of MMR mutations on patient derived GBM cell lines. Results on MSH2 and MSH6 knockout cell lines treated with TMZ showed the reproduction of the hypermutation phenotype in vitro, but only in MGMT promoter methylated cell lines.
Moreover, the DNA analysis of the patient showed one shared mutation in high copy number in all of the nine samples: a mutation in EGFR G598V. We hypothesise that subsequent tumours developed from an original clone bearing this mutation. This mutated oncogene is located on an extrachromosomal circular DNA structure known as a double minute (DM), which is found in an estimated 40% of GBM. We performed linked-read sequencing using the 10X Genomics Chromium technology to reconstruct the DM and shed light on its emergence.
Subjects/Keywords: Glioblastoma; Genetics; Evolution; Hypermutation; Recurrence
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APA ·
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Manager
APA (6th Edition):
Wendler, A. S. (2019). The Evolution of Glioblastoma: A Single Case Study. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/291699
Chicago Manual of Style (16th Edition):
Wendler, Astrid Svenja. “The Evolution of Glioblastoma: A Single Case Study.” 2019. Doctoral Dissertation, University of Cambridge. Accessed February 27, 2021.
https://www.repository.cam.ac.uk/handle/1810/291699.
MLA Handbook (7th Edition):
Wendler, Astrid Svenja. “The Evolution of Glioblastoma: A Single Case Study.” 2019. Web. 27 Feb 2021.
Vancouver:
Wendler AS. The Evolution of Glioblastoma: A Single Case Study. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Feb 27].
Available from: https://www.repository.cam.ac.uk/handle/1810/291699.
Council of Science Editors:
Wendler AS. The Evolution of Glioblastoma: A Single Case Study. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/291699
Duke University
5.
Mabe, Nathaniel Wesley.
Defining and Targeting Epigenetic Rewiring During Tumor Progression
.
Degree: 2019, Duke University
URL: http://hdl.handle.net/10161/18682
► Tumor recurrence following initial treatment is the leading cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression…
(more)
▼ Tumor
recurrence following initial treatment is the leading cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression and to facilitate appropriate responses to environmental cues. However, it is increasingly appreciated that epigenetic dysregulation directly promotes therapeutic resistance and tumor progression. While genetic alterations have been shown to promote tumor progression, the contribution of non-genetic drivers of
recurrence remains unexplored. In the current work, we utilized genetically engineered mouse models of breast cancer
recurrence to evaluate the contribution of epigenetic plasticity to tumor
recurrence and chemoresistance. First, we found that recurrent tumors undergo dramatic epigenetic and transcriptional reprogramming, partially through acquisition of an epithelial-to-mesenchymal transition (EMT). EMT promoted epigenetic silencing of tumor suppressor Par-4 through a unique, bivalent histone configuration. This bivalent configuration conferred plasticity to Par-4, and Par-4 silencing was reversed with epigenetic inhibitors of EHZ2 and HDAC. Further, Par-4 re-expression sensitized recurrent tumors to commonly utilized microtubule-targeting chemotherapeutics through altered cytoskeletal regulation. Second, we found that recurrent tumor epigenetic and transcriptional rewiring conferred sensitivity to G9a inhibitors. G9a inhibition promoted recurrent tumor cell necroptosis through demethylation of genes involved in a pro-inflammatory cytokine program. Further, knockout of G9a protein delayed the time until mammary tumors recurred in vivo. Collectively, our studies demonstrate that epigenetic dysregulation is a key feature of breast cancer progression, and pharmacologic strategies designed to target epigenetic enzymes underlying these processes may be of clinical value in the treatment of recurrent breast cancer.
Advisors/Committee Members: Alvarez, James (advisor).
Subjects/Keywords: Pharmacology;
Cancer;
Epigenetics;
Recurrence
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APA ·
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CSE |
Export
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Manager
APA (6th Edition):
Mabe, N. W. (2019). Defining and Targeting Epigenetic Rewiring During Tumor Progression
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/18682
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mabe, Nathaniel Wesley. “Defining and Targeting Epigenetic Rewiring During Tumor Progression
.” 2019. Thesis, Duke University. Accessed February 27, 2021.
http://hdl.handle.net/10161/18682.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mabe, Nathaniel Wesley. “Defining and Targeting Epigenetic Rewiring During Tumor Progression
.” 2019. Web. 27 Feb 2021.
Vancouver:
Mabe NW. Defining and Targeting Epigenetic Rewiring During Tumor Progression
. [Internet] [Thesis]. Duke University; 2019. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10161/18682.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mabe NW. Defining and Targeting Epigenetic Rewiring During Tumor Progression
. [Thesis]. Duke University; 2019. Available from: http://hdl.handle.net/10161/18682
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
6.
Wendler, Astrid Svenja.
The evolution of glioblastoma : a single case study.
Degree: PhD, 2019, University of Cambridge
URL: https://doi.org/10.17863/CAM.38859
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774726
► Glioblastoma multiforme (GBM) is the most malignant and common primary brain cancer in adults, with a 2.5-year survival of only ~8%. In this single case…
(more)
▼ Glioblastoma multiforme (GBM) is the most malignant and common primary brain cancer in adults, with a 2.5-year survival of only ~8%. In this single case study we have analysed the development of a primary GBM over four years. We performed WGS and RNAseq on three, spatially distinct samples of the treatment naïve primary tumour, the first recurrence and the fatal second recurrence. We observed a massive increase in mutations from the first to the second recurrence, showing predominantly C > T and A > G transitions, which is a pattern typical of TMZ treatment. The fact that the hypermutation did not appear until the second recurrence raises questions about the mechanism of hypermutation. The therapeutic apoptotic action of TMZ relies on the function of the mismatch repair (MMR) pathway. In the second recurrence we observed disruptive mutations of MSH6, MSH2, PMS2 and MLH1 all of which are crucial to the MMR pathway. The pattern of mutations of these genes varied between the samples taken from the second recurrence, however, all three samples showed hypermutation. This suggests that the hypermutation observed after TMZ treatment only occurs if the MMR is damaged, but that this damage does not need to be at a specific locus. Using the CRISPR-Cas9 technology we explored the impact of MMR mutations on patient derived GBM cell lines. Results on MSH2 and MSH6 knockout cell lines treated with TMZ showed the reproduction of the hypermutation phenotype in vitro, but only in MGMT promoter methylated cell lines. Moreover, the DNA analysis of the patient showed one shared mutation in high copy number in all of the nine samples: a mutation in EGFR G598V. We hypothesise that subsequent tumours developed from an original clone bearing this mutation. This mutated oncogene is located on an extrachromosomal circular DNA structure known as a double minute (DM), which is found in an estimated 40% of GBM. We performed linked-read sequencing using the 10X Genomics Chromium technology to reconstruct the DM and shed light on its emergence.
Subjects/Keywords: Glioblastoma; Genetics; Evolution; Hypermutation; Recurrence
Record Details
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wendler, A. S. (2019). The evolution of glioblastoma : a single case study. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.38859 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774726
Chicago Manual of Style (16th Edition):
Wendler, Astrid Svenja. “The evolution of glioblastoma : a single case study.” 2019. Doctoral Dissertation, University of Cambridge. Accessed February 27, 2021.
https://doi.org/10.17863/CAM.38859 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774726.
MLA Handbook (7th Edition):
Wendler, Astrid Svenja. “The evolution of glioblastoma : a single case study.” 2019. Web. 27 Feb 2021.
Vancouver:
Wendler AS. The evolution of glioblastoma : a single case study. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Feb 27].
Available from: https://doi.org/10.17863/CAM.38859 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774726.
Council of Science Editors:
Wendler AS. The evolution of glioblastoma : a single case study. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://doi.org/10.17863/CAM.38859 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774726
University of Sydney
7.
Shammugasamy, Balakrishnan.
Citrus Peel in Maintaining Cellular Quiescence of Prostate Cancer
.
Degree: 2019, University of Sydney
URL: http://hdl.handle.net/2123/19977
► Cancer recurrence remains a major concern for cancer patients despite the significant advancement in cancer treatment. Cell cycle re-entry of quiescent cancer cells has been…
(more)
▼ Cancer recurrence remains a major concern for cancer patients despite the significant advancement in cancer treatment. Cell cycle re-entry of quiescent cancer cells has been implicated as a key factor for cancer recurrence. The slow progression of prostate cancer allows a window of opportunity for intervention through diet. Therefore, the aim of this thesis was to evaluate the potential use of citrus peel extract in halting the cell cycle re-entry of quiescent prostate cancer cells. Firstly, water extract and hexane extract of citrus peel were prepared using a maceration technique. The anticancer activity of the extracts was evaluated on prostate cancer PC-3 and LNCaP cells using in-vitro assays. The cell viability analysis showed that hexane extract was more effective in reducing cell viability compared to water extract in both cell lines. For cell cycle analysis, quiescent prostate cancer PC-3 and LNCAP cells were released to re-enter cell cycle in the presence of extract. Water extract completely inhibited the entry of quiescent cells from G0/G1 phase to S phase upon release from quiescence. In contrast, the hexane extract completely allowed the cells progress to S and G2/M phase. However, both extracts significantly decreased the DNA synthesis rate in PC-3 cells compared to the control when analysed using EdU incorporation assay. Hesperidin and naringin, the predominant flavonoid compounds in water extract, exhibited negligible cell cycle re-entry inhibitory effect on quiescent PC-3 cells suggesting the contribution of other bioactive compounds in the extract. More importantly, the water extract showed no toxicity when tested on the normal human fibroblast cells. Subsequently, solvent extraction and chromatography techniques were used to identify the compounds in water extract that are responsible for the cell cycle re-entry inhibitory effect. The results showed that the water fraction exhibited the highest inhibitory effect among the fractions tested. Not only that, the inhibitory activity of fractions was lower than the water extract suggesting the compounds exhibited a greater effect in combination and the presence of a synergic effect. Using various analytical methods, citric acid was identified as one of the cell cycle re-entry inhibitor compounds present in water extract. The cell viability assay showed the IC50 of citric acid for prostate cancer PC-3 cells and normal epithelial prostate RWPE-1 cells were almost similar. However, citric acid significantly exhibited higher cell toxicity effect on PC-3 cells than RWPE-1 cells at a concentration above 1 mg/mL indicating the specific toxicity of citric acid on cancer cells. Not only that, the citric acid showed no significant toxicity effect on human normal fibroblast GM3348 cells when tested on similar concentration. As the mechanisms of cell cycle re-entry of quiescent cells remain largely unclear, a study was attempted to elucidate the protein changes by the citric acid at the cellular level. The proteomic experiment results revealed several proteins…
Subjects/Keywords: prostate;
cancer;
citrus;
recurrence;
food
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Shammugasamy, B. (2019). Citrus Peel in Maintaining Cellular Quiescence of Prostate Cancer
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/19977
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shammugasamy, Balakrishnan. “Citrus Peel in Maintaining Cellular Quiescence of Prostate Cancer
.” 2019. Thesis, University of Sydney. Accessed February 27, 2021.
http://hdl.handle.net/2123/19977.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shammugasamy, Balakrishnan. “Citrus Peel in Maintaining Cellular Quiescence of Prostate Cancer
.” 2019. Web. 27 Feb 2021.
Vancouver:
Shammugasamy B. Citrus Peel in Maintaining Cellular Quiescence of Prostate Cancer
. [Internet] [Thesis]. University of Sydney; 2019. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2123/19977.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shammugasamy B. Citrus Peel in Maintaining Cellular Quiescence of Prostate Cancer
. [Thesis]. University of Sydney; 2019. Available from: http://hdl.handle.net/2123/19977
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Western Ontario
8.
Rabbani, Mahnaz.
The Recurrence-Based Analysis of Intracranial Pressure.
Degree: 2017, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/5156
► Modern computational approaches tied together with the power of mathematical science has pushed us closer to reach a deeper understanding of complex dynamical systems. Real-world…
(more)
▼ Modern computational approaches tied together with the power of mathematical science has pushed us closer to reach a deeper understanding of complex dynamical systems. Real-world biological and physiological systems now can be studied on account of the accessibility to fast, cheap and powerful computers. In particular, the field of neuroscience and brain data analysis has grown significantly in the recent years. Recurrence plots (RPs) are a relatively new approach for the analysis of nonlinear, non-stationary and noisy data. Rooted in topological properties of the system, RP visualizes the recurrence states of the dynamical system. Armed with the recurrence quantification measures, RP is even more rigorous in exploring and quantifying real-world dynamical system.
In the present work, we benefit from the RP and RQA methods to study the behavior of intracranial pressure (ICP) waveforms. ICP is defined as the fluid pressure inside the skull which carries important information associated with the status of the patient. Our main goal is to detect sudden changes or extreme regime changing in these signals. Patterns appearing in RP can shed light on fundamental characteristics of the system. Our results suggest distinguishable patterns in the RPs of some subjects which are not detectable in the raw ICP signals. This work sets up the workflow for using RP analysis in online ICP monitoring of brain-injured patients.
Subjects/Keywords: Intracranial pressure (ICP) analysis; recurrence plot (RP); recurrence quantification analysis (RQA)
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APA (6th Edition):
Rabbani, M. (2017). The Recurrence-Based Analysis of Intracranial Pressure. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5156
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rabbani, Mahnaz. “The Recurrence-Based Analysis of Intracranial Pressure.” 2017. Thesis, University of Western Ontario. Accessed February 27, 2021.
https://ir.lib.uwo.ca/etd/5156.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rabbani, Mahnaz. “The Recurrence-Based Analysis of Intracranial Pressure.” 2017. Web. 27 Feb 2021.
Vancouver:
Rabbani M. The Recurrence-Based Analysis of Intracranial Pressure. [Internet] [Thesis]. University of Western Ontario; 2017. [cited 2021 Feb 27].
Available from: https://ir.lib.uwo.ca/etd/5156.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rabbani M. The Recurrence-Based Analysis of Intracranial Pressure. [Thesis]. University of Western Ontario; 2017. Available from: https://ir.lib.uwo.ca/etd/5156
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Rochester
9.
Aldersley, Jordan.
Shared Role for Critical Mediator Genes in Ras-Dependent
and Ras-Independent Malignant Cell Transformation.
Degree: PhD, 2015, University of Rochester
URL: http://hdl.handle.net/1802/29353
► Diverse types of cancer cells share a common set of critical properties that emerge in response to distinct oncogenic mutations. This suggests a role for…
(more)
▼ Diverse types of cancer cells share a common set of
critical properties that emerge in response to distinct oncogenic
mutations. This suggests a role for common underlying mechanisms
that mediate malignant cell transformation downstream of a variety
of oncogenic drivers. Consistent with this idea, our lab has
uncovered a set of genes responding synergistically to cooperating
p53 and ras mutations that are critical to the cancer phenotype,
and have an expression signature conserved among various types of
cancers (Cooperation Response Genes, or CRGs). Using genetic models
that permit modulation of oncogenic driver activities and/or
identities in cancer cells, we show that the critical role of CRG
expression is, at least in part, independent of the identity of
given oncogenic drivers. In a conditional KrasG12D-driven model of
pancreatic ductal adenocarcinoma (PDAC), the sustained loss of
KrasG12D in vivo results in reductions in tumor volume commonly
followed by c-Met pathway activation and tumor recurrence. In this
model, CRG expression and functional relevance appear conserved
together with key features of the metabolic phenotype established
by Kras in the Met-driven recurrent cells. Oncogenic mutations play
a continuous role in the maintenance of the cancer phenotype, and
consistent with this notion expression of ~75% of CRGs tracks with
ras attenuation after 3 days in vitro, in both the aforementioned
PDAC model and a second independent model in which abrogation of
the driving HrasG12V allele in transformed murine colon cells is
achieved by cre/loxp-mediated recombination. Notably, expression of
the other 25% of CRGs remains unaltered following attenuation of
the primary oncogenic driver, providing evidence for hitherto
unknown mechanisms which function to maintain the transformed state
independently of the continuous presence of oncogenic mutations.
Genetic perturbation of CRGs that are unresponsive to the
alteration of oncogenic mutations resulted in tumor inhibition in
secondary xenograft assays, suggesting that CRGs may represent an
attractive new class of intervention targets, particularly in
scenarios where molecular targeting of cancer mutations rapidly
selects for treatment-resistant cancer cells that activate
alternate oncogenic drivers.
Subjects/Keywords: Acquired Oncogene Independence; Oncogene Addiction Recurrence
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APA (6th Edition):
Aldersley, J. (2015). Shared Role for Critical Mediator Genes in Ras-Dependent
and Ras-Independent Malignant Cell Transformation. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/29353
Chicago Manual of Style (16th Edition):
Aldersley, Jordan. “Shared Role for Critical Mediator Genes in Ras-Dependent
and Ras-Independent Malignant Cell Transformation.” 2015. Doctoral Dissertation, University of Rochester. Accessed February 27, 2021.
http://hdl.handle.net/1802/29353.
MLA Handbook (7th Edition):
Aldersley, Jordan. “Shared Role for Critical Mediator Genes in Ras-Dependent
and Ras-Independent Malignant Cell Transformation.” 2015. Web. 27 Feb 2021.
Vancouver:
Aldersley J. Shared Role for Critical Mediator Genes in Ras-Dependent
and Ras-Independent Malignant Cell Transformation. [Internet] [Doctoral dissertation]. University of Rochester; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1802/29353.
Council of Science Editors:
Aldersley J. Shared Role for Critical Mediator Genes in Ras-Dependent
and Ras-Independent Malignant Cell Transformation. [Doctoral Dissertation]. University of Rochester; 2015. Available from: http://hdl.handle.net/1802/29353
McMaster University
10.
Adile, Ashley Ann.
Therapeutic targeting of metastatic recurrences of pediatric medulloblastoma by selective kinase and histone deacetylase inhibitors.
Degree: MSc, 2020, McMaster University
URL: http://hdl.handle.net/11375/25512
► Medulloblastoma (MB) is the most common malignant pediatric brain tumour. Of its four distinct molecular subgroups (WNT, SHH, Group 3, and Group 4), Group 3…
(more)
▼ Medulloblastoma (MB) is the most common malignant pediatric brain tumour. Of its four distinct molecular subgroups (WNT, SHH, Group 3, and Group 4), Group 3 MB patients hold the worst clinical prognosis due to their high incidence of tumour recurrence and metastasis to the spinal leptomeninges. Relapsed Group 3 MB patients, particularly those with MYC amplification (known as Group 3𝛾), carry a mortality rate of nearly 100%, given the paucity of effective therapeutic options currently available. The most common cause of mortality amongst these patients is leptomeningeal metastasis, yet this metastatic disease is poorly characterized. Our understanding of MB tumour recurrence and leptomeningeal metastasis is further encumbered by the rare clinical opportunities at which specimens may be collected from relapsed patients. We were able to circumvent this obstacle by establishing a patient-derived xenograft mouse-adapted therapy model, which mimics the treatments administered in the clinic and in turn, recapitulates both local and metastatic human MB recurrence. This model system enabled the collection of valuable, patient-derived Group 3𝛾 MB tumour cells from the spinal leptomeninges at relapse. It provides an opportunity for chemical screening, with the aim of identifying small molecule inhibitors capable of eradicating these cells. Existing studies on MB leptomeningeal dissemination at diagnosis suggest that effective treatments may target signalling proteins, such as phosphatidylinositol 3-kinases and histone deacetylases (HDACs). Therefore, I hypothesized that selective kinase and HDAC inhibitors would pose as effective therapies against Group 3𝛾 MB metastatic recurrences.
In this thesis, I conducted a high-throughput screen of 640 kinase inhibitors and robust testing of novel HDAC6-selective inhibitors against these treatment-refractory, metastatic cells. Here, I showed that metastatic recurrences of Group 3𝛾 MB are therapeutically vulnerable to selective inhibitors of checkpoint kinase 1 (CHK1), platelet-derived growth factor receptor beta (PDGFRβ), and HDAC6. Functional studies demonstrated that these inhibitors selectively target the aggressive, migratory Group 3𝛾 MB cells, while sparing healthy neural stem cells. They also showed effective blood-brain-barrier penetration in silico and in vitro, while significantly reducing MB tumour cell properties that are often associated with treatment failure. Taken together, my thesis highlights specific inhibitors of CHK1, PDGFRβ, and HDAC6 that effectively target MB tumour cells that fuel treatment-refractory leptomeningeal metastases. With additional preclinical validation, these compounds may serve as potent therapeutic options to extend survival and improve the quality of life for patients that are ostensibly limited to palliation.
Thesis
Master of Science (MSc)
Medulloblastoma is an aggressive brain cancer in children. While current standard treatment improves patient survival, 30-40% of all medulloblastoma patients relapse at local (brain) or metastatic…
Advisors/Committee Members: Singh, Sheila Kumari, Biochemistry and Biomedical Sciences.
Subjects/Keywords: Medulloblastoma; Metastatic recurrence; Targeted therapy; Leptomeningeal metastasis
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APA (6th Edition):
Adile, A. A. (2020). Therapeutic targeting of metastatic recurrences of pediatric medulloblastoma by selective kinase and histone deacetylase inhibitors. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/25512
Chicago Manual of Style (16th Edition):
Adile, Ashley Ann. “Therapeutic targeting of metastatic recurrences of pediatric medulloblastoma by selective kinase and histone deacetylase inhibitors.” 2020. Masters Thesis, McMaster University. Accessed February 27, 2021.
http://hdl.handle.net/11375/25512.
MLA Handbook (7th Edition):
Adile, Ashley Ann. “Therapeutic targeting of metastatic recurrences of pediatric medulloblastoma by selective kinase and histone deacetylase inhibitors.” 2020. Web. 27 Feb 2021.
Vancouver:
Adile AA. Therapeutic targeting of metastatic recurrences of pediatric medulloblastoma by selective kinase and histone deacetylase inhibitors. [Internet] [Masters thesis]. McMaster University; 2020. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11375/25512.
Council of Science Editors:
Adile AA. Therapeutic targeting of metastatic recurrences of pediatric medulloblastoma by selective kinase and histone deacetylase inhibitors. [Masters Thesis]. McMaster University; 2020. Available from: http://hdl.handle.net/11375/25512
Universiteit Utrecht
11.
Zierikzee, D.
ACTH profiles in dogs after transsphenoidal hypophysectomy as an indicator for recurrence.
Degree: 2015, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/308315
► One of the most encountered endocrinological disorders in dogs in the veterinary practice is Cushing’s syndrome or hypercortisolism a disorder of the pituitary gland or…
(more)
▼ One of the most encountered endocrinological disorders in dogs in the veterinary practice is Cushing’s syndrome or hypercortisolism a disorder of the pituitary gland or adrenal glands which causes the adrenal glands to secrete an excess of cortisol. Hypercortisolism causes a wide variety of symptoms and not all are always seen in every patient.
Dogs with this disease can be treated with medication or in case of pituitary-dependent hypercortisolism a surgical procedure called a transsphenoidal hypofysectomy can be performed. In Europe this surgery is only performed at the University Clinic of companion animals in Utrecht, the Netherlands. One of the most common complications of a transsphenoidal hypophysectomy is the possibility of the
recurrence of hypercortisolism due to regrowth of the pituitary cells.
The objective of this study is to assess immediate postoperative ACTH profiles of dogs that underwent hypophysectomy and correlate peri-operative ACTH levels with the
recurrence of pituitary-dependent hypercortisolism in the long-term follow up.
Advisors/Committee Members: Rijn, S.J. van, Meij, B.P..
Subjects/Keywords: ACTH; hypophysectomy; dogs; Cushing; recurrence; hypercortisolism
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APA ·
Chicago ·
MLA ·
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CSE |
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Manager
APA (6th Edition):
Zierikzee, D. (2015). ACTH profiles in dogs after transsphenoidal hypophysectomy as an indicator for recurrence. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/308315
Chicago Manual of Style (16th Edition):
Zierikzee, D. “ACTH profiles in dogs after transsphenoidal hypophysectomy as an indicator for recurrence.” 2015. Masters Thesis, Universiteit Utrecht. Accessed February 27, 2021.
http://dspace.library.uu.nl:8080/handle/1874/308315.
MLA Handbook (7th Edition):
Zierikzee, D. “ACTH profiles in dogs after transsphenoidal hypophysectomy as an indicator for recurrence.” 2015. Web. 27 Feb 2021.
Vancouver:
Zierikzee D. ACTH profiles in dogs after transsphenoidal hypophysectomy as an indicator for recurrence. [Internet] [Masters thesis]. Universiteit Utrecht; 2015. [cited 2021 Feb 27].
Available from: http://dspace.library.uu.nl:8080/handle/1874/308315.
Council of Science Editors:
Zierikzee D. ACTH profiles in dogs after transsphenoidal hypophysectomy as an indicator for recurrence. [Masters Thesis]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/308315
Addis Ababa University
12.
Fitsum, Dagmawi.
FACTORS DETERMINING RHEUMATIC FEVER RECURRENCE AMONG RHEUMATIC HEART DISEASE PATIENTS WHO ARE TAKING MONTHLY BENZANTHINE G PENICILLIN PROPHYLAXIS AT PEDIATRIC CARDIAC CLINIC, TIKUR ANBESSA SPEICIALIZED TEACHING HOSPITAL, ADDIS ABABA UNIVERSITY, COLLEGE OF HEALTH SCIENCES, DEPARTMENT OF PEDIATRICS AND CHILD HEALTH ADDIS ABABA, 2014
.
Degree: 2014, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/5855
► ABSTRACT Introduction: Rheumatic fever is a major cause of acquired heart disease in children worldwide, with the disease occurring most frequently in underdeveloped countries. ARF…
(more)
▼ ABSTRACT Introduction: Rheumatic fever is a major cause of acquired heart disease in children worldwide, with the disease occurring most frequently in underdeveloped countries. ARF and its chronic sequela RHD remain significant causes of morbidity and mortality in Ethiopia. The main priority of long-term management of ARF or RHD is to ensure secondary prophylaxis is adhered to. Despite its importance, the rate and risk factors of rheumatic fever
recurrence is not known in Ethiopian children with ARF/RHD. This study will identify ARF
recurrence rates and the extent to which ARF is concentrated in certain populations based on age, sex, education, income, and types of valves involved. Objectives: The objective of this study was to identify risk factors for rheumatic
recurrence in patients receiving monthly benzanthine G penicillin prophylaxis. Method: We conducted a retrospective review of medical records of 211 eligible patients with rheumatic heart disease at TASH, pediatric cardiac clinic from April /2014 to Aug. 2014. A descriptive and analytic statistics was used as applicable. Statistically significant associations were set at P-value of <0.05. Results: A total of 211 children’s medical records were reviewed. Rheumatic fever
recurrence occurred in 22 (10.4%) of the 211 patients. Patients with
recurrence of RF were less adherent to monthly BGP prophylaxis than patients without
recurrence of RF the odds of nonadherent patients was 19.42 (odds ratio= 19.42, CI= (6.885, 54.766) P= 0.000). Non-adherence to BGP prophylaxis at any time during follow up was detected in 10.9% (23 of the 211) of study subjects. Rates of non-adherence were higher in the group of patients that were younger (27.3%, 9.6%, and 7.4% for children less than or equal to 5 year, 6 to 10 year, and 11 to 15 year of age, respectively) than in the group of patients who were older (p=0.046). Conclusion: We recommend implementation of a registry, and a system of active search of missing patients in every service responsible for the follow-up of RHD/RF patients. Measures to increase adherence to secondary prophylaxis need to be implemented formally, once non-adherence to secondary prophylaxis is the main cause of RF
recurrence. Key words: Rheumatic fever
recurrence, rheumatic heart disease.
Advisors/Committee Members: Amha Mekasha,( MD, MSc Associate professor of pediatrics & child health) (advisor).
Subjects/Keywords: Rheumatic fever recurrence; rheumatic heart disease
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Manager
APA (6th Edition):
Fitsum, D. (2014). FACTORS DETERMINING RHEUMATIC FEVER RECURRENCE AMONG RHEUMATIC HEART DISEASE PATIENTS WHO ARE TAKING MONTHLY BENZANTHINE G PENICILLIN PROPHYLAXIS AT PEDIATRIC CARDIAC CLINIC, TIKUR ANBESSA SPEICIALIZED TEACHING HOSPITAL, ADDIS ABABA UNIVERSITY, COLLEGE OF HEALTH SCIENCES, DEPARTMENT OF PEDIATRICS AND CHILD HEALTH ADDIS ABABA, 2014
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5855
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fitsum, Dagmawi. “FACTORS DETERMINING RHEUMATIC FEVER RECURRENCE AMONG RHEUMATIC HEART DISEASE PATIENTS WHO ARE TAKING MONTHLY BENZANTHINE G PENICILLIN PROPHYLAXIS AT PEDIATRIC CARDIAC CLINIC, TIKUR ANBESSA SPEICIALIZED TEACHING HOSPITAL, ADDIS ABABA UNIVERSITY, COLLEGE OF HEALTH SCIENCES, DEPARTMENT OF PEDIATRICS AND CHILD HEALTH ADDIS ABABA, 2014
.” 2014. Thesis, Addis Ababa University. Accessed February 27, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/5855.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fitsum, Dagmawi. “FACTORS DETERMINING RHEUMATIC FEVER RECURRENCE AMONG RHEUMATIC HEART DISEASE PATIENTS WHO ARE TAKING MONTHLY BENZANTHINE G PENICILLIN PROPHYLAXIS AT PEDIATRIC CARDIAC CLINIC, TIKUR ANBESSA SPEICIALIZED TEACHING HOSPITAL, ADDIS ABABA UNIVERSITY, COLLEGE OF HEALTH SCIENCES, DEPARTMENT OF PEDIATRICS AND CHILD HEALTH ADDIS ABABA, 2014
.” 2014. Web. 27 Feb 2021.
Vancouver:
Fitsum D. FACTORS DETERMINING RHEUMATIC FEVER RECURRENCE AMONG RHEUMATIC HEART DISEASE PATIENTS WHO ARE TAKING MONTHLY BENZANTHINE G PENICILLIN PROPHYLAXIS AT PEDIATRIC CARDIAC CLINIC, TIKUR ANBESSA SPEICIALIZED TEACHING HOSPITAL, ADDIS ABABA UNIVERSITY, COLLEGE OF HEALTH SCIENCES, DEPARTMENT OF PEDIATRICS AND CHILD HEALTH ADDIS ABABA, 2014
. [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Feb 27].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/5855.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fitsum D. FACTORS DETERMINING RHEUMATIC FEVER RECURRENCE AMONG RHEUMATIC HEART DISEASE PATIENTS WHO ARE TAKING MONTHLY BENZANTHINE G PENICILLIN PROPHYLAXIS AT PEDIATRIC CARDIAC CLINIC, TIKUR ANBESSA SPEICIALIZED TEACHING HOSPITAL, ADDIS ABABA UNIVERSITY, COLLEGE OF HEALTH SCIENCES, DEPARTMENT OF PEDIATRICS AND CHILD HEALTH ADDIS ABABA, 2014
. [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5855
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
13.
Ehman, Dylan Alexander.
Investigating Differential Expression of MicroRNAs Related to Recurrence in the Luminal Breast Cancer Subtype.
Degree: 2014, University of Toronto
URL: http://hdl.handle.net/1807/67924
► Breast cancer is a heterogeneous disease, and patients with the luminal subtype have a range of outcomes unable to be predicted by current clinical methods.…
(more)
▼ Breast cancer is a heterogeneous disease, and patients with the luminal subtype have a range of outcomes unable to be predicted by current clinical methods. My hypothesis was that microRNA (miRNA) expression profiling might provide a method of discriminating tumours of this subtype into good and poor prognosis groups, and reveal miRNAs involved in recurrence.Expression profiling revealed nine miRNAs significantly differentially expressed in luminal tumours from patients with recurrence compared to patients without recurrence. Four, miR-135a-5p, miR-140-5p, miR-218-5p, and miR-200a-3p, selected for technical validation were confirmed as differentially expressed. Functional analysis in an in vitro breast cancer model revealed a reduction in cellular migration when miR-218-5p was ectopically overexpressed in two different assays, suggesting a possible association of miR-218-5p with metastasis, an important factor in recurrence. The expression of these miRNAs may allow improved prognostication in luminal tumours, and provide avenues of further research in breast cancer pathology.
M.Sc.
Advisors/Committee Members: Andrulis, Irene L, Molecular and Medical Genetics.
Subjects/Keywords: breast; expression; luminal; microRNA; prognosis; recurrence; 0369
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APA (6th Edition):
Ehman, D. A. (2014). Investigating Differential Expression of MicroRNAs Related to Recurrence in the Luminal Breast Cancer Subtype. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/67924
Chicago Manual of Style (16th Edition):
Ehman, Dylan Alexander. “Investigating Differential Expression of MicroRNAs Related to Recurrence in the Luminal Breast Cancer Subtype.” 2014. Masters Thesis, University of Toronto. Accessed February 27, 2021.
http://hdl.handle.net/1807/67924.
MLA Handbook (7th Edition):
Ehman, Dylan Alexander. “Investigating Differential Expression of MicroRNAs Related to Recurrence in the Luminal Breast Cancer Subtype.” 2014. Web. 27 Feb 2021.
Vancouver:
Ehman DA. Investigating Differential Expression of MicroRNAs Related to Recurrence in the Luminal Breast Cancer Subtype. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1807/67924.
Council of Science Editors:
Ehman DA. Investigating Differential Expression of MicroRNAs Related to Recurrence in the Luminal Breast Cancer Subtype. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/67924
University of Toronto
14.
Malik, Atiqa.
Recurrence of Inguinal Hernia in General and Hernia Specialty Hospitals in Ontario, Canada.
Degree: 2012, University of Toronto
URL: http://hdl.handle.net/1807/33437
► BACKGROUND: We compared hernia recurrence rates in patients undergoing primary elective inguinal hernia repair at general hospitals with the Shouldice Hospital in Ontario, Canada. METHODS:…
(more)
▼ BACKGROUND:
We compared hernia recurrence rates in patients undergoing primary elective inguinal hernia repair at general hospitals with the Shouldice Hospital in Ontario, Canada.
METHODS:
We conducted an administrative data analysis of persons who underwent inguinal hernia repair in Ontario, Canada from 1993-2007. Risk of recurrent hernia repair was estimated according to hospital type and volume, using Cox proportional-hazards regression models.
RESULTS:
Recurrence risk in the lowest volume quartile was 5.7%, compared to 3.9% at high volume general hospitals and 1.1% at the Shouldice hospital. Compared to persons who had surgery at the lowest volume hospitals, hernia recurrence among Shouldice Hospital patients was substantially lower after adjustment for confounding variables (hazard ratio 0.18, CI (0.16 to 0.19), P <0.001).
CONCLUSIONS:
Persons who had elective primary inguinal hernia repair at the Shouldice Hospital had a substantially lower risk of recurrence than those treated at general hospitals, including high volume general hospitals.
MAST
Advisors/Committee Members: Urbach, David Robert, Medical Science.
Subjects/Keywords: Surgery; Inguinal Hernia; Shouldice; Recurrence; 0564
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APA (6th Edition):
Malik, A. (2012). Recurrence of Inguinal Hernia in General and Hernia Specialty Hospitals in Ontario, Canada. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/33437
Chicago Manual of Style (16th Edition):
Malik, Atiqa. “Recurrence of Inguinal Hernia in General and Hernia Specialty Hospitals in Ontario, Canada.” 2012. Masters Thesis, University of Toronto. Accessed February 27, 2021.
http://hdl.handle.net/1807/33437.
MLA Handbook (7th Edition):
Malik, Atiqa. “Recurrence of Inguinal Hernia in General and Hernia Specialty Hospitals in Ontario, Canada.” 2012. Web. 27 Feb 2021.
Vancouver:
Malik A. Recurrence of Inguinal Hernia in General and Hernia Specialty Hospitals in Ontario, Canada. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1807/33437.
Council of Science Editors:
Malik A. Recurrence of Inguinal Hernia in General and Hernia Specialty Hospitals in Ontario, Canada. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/33437
Virginia Commonwealth University
15.
Philip, Alexander.
Association between T Cells-Related Gene Expression and Fibrosis Progression in HCV Recurrence disease.
Degree: MS, Physiology, 2011, Virginia Commonwealth University
URL: https://doi.org/10.25772/24Z5-B719
;
https://scholarscompass.vcu.edu/etd/2548
► Hepatitis C virus (HCV) is the major cause of chronic hepatitis worldwide and a leading cause for liver transplant. Unfortunately, graft HCV infection is a…
(more)
▼ Hepatitis C virus (HCV) is the major cause of chronic hepatitis worldwide and a leading cause for liver transplant. Unfortunately, graft HCV infection is a universal phenomenon despite of pre-transplant prophylactic strategies. Acute HCV infection and innate immune responses elicit an inflammatory scenario that triggers the recruitment of adaptive immune response cells. Of those chronically infected, 30% experience accelerated fibrosis with concomitant cirrhosis development within 5 years post-LT and require re-transplant. With many patients responding unfavorably to antivirals and ineffective vaccines, much attention is now placed on T cell immunity in controlling HCV infection.
This study represents a retrospective analysis that examined the association of T cells with respect to liver fibrosis severity progression in a prospective cohort of biopsy samples taken from 27 patients at the time of HCV
recurrence disease diagnosis post-LT. For those patients, the fibrosis progression was scored 36 months post-LT by Metavir scoring system. Liver biopsies were classified based on fibrosis severity as Mild (G1; n = 12), Moderate (G2; n = 6), and Severe (G3; n = 9). Additionally, an independent set of liver biopsy samples, taken according to fibrosis severity progression, was classified (G1; n =3, G3; n = 4) and used as a validation set for CD4 gene expression.
Real time PCR was performed to study the expression of immune-related genes using the Taqman® probe system. From the results analysis, the CD4 T cell marker encoding gene was down-regulated (2.9-fold) in G3 with respect to G1; although, only borderline significant (p = 0.052). This suggests an inverse relationship of CD4+T cell related-genes expression with respect to worse fibrosis progression in HCV
recurrence diagnosed recipients. The validation samples showed a similar trend (1.8 fold decrease in G3 with respect to G1), although not significant. This may be due to impaired T cell function resulting from T cell exhaustion, poor dendritic cell priming and activation, or the use of immunosuppressant drugs. To conclude, CD4 could be a potential biomarker to help in identifying HCV recurrent patients with a high risk of fibrosis development soon after LT.
Advisors/Committee Members: Valeria Mas.
Subjects/Keywords: HCV Recurrence T-Cells; Life Sciences; Physiology
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APA (6th Edition):
Philip, A. (2011). Association between T Cells-Related Gene Expression and Fibrosis Progression in HCV Recurrence disease. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/24Z5-B719 ; https://scholarscompass.vcu.edu/etd/2548
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Philip, Alexander. “Association between T Cells-Related Gene Expression and Fibrosis Progression in HCV Recurrence disease.” 2011. Thesis, Virginia Commonwealth University. Accessed February 27, 2021.
https://doi.org/10.25772/24Z5-B719 ; https://scholarscompass.vcu.edu/etd/2548.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Philip, Alexander. “Association between T Cells-Related Gene Expression and Fibrosis Progression in HCV Recurrence disease.” 2011. Web. 27 Feb 2021.
Vancouver:
Philip A. Association between T Cells-Related Gene Expression and Fibrosis Progression in HCV Recurrence disease. [Internet] [Thesis]. Virginia Commonwealth University; 2011. [cited 2021 Feb 27].
Available from: https://doi.org/10.25772/24Z5-B719 ; https://scholarscompass.vcu.edu/etd/2548.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Philip A. Association between T Cells-Related Gene Expression and Fibrosis Progression in HCV Recurrence disease. [Thesis]. Virginia Commonwealth University; 2011. Available from: https://doi.org/10.25772/24Z5-B719 ; https://scholarscompass.vcu.edu/etd/2548
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Washington State University
16.
[No author].
Recurrence Representations
.
Degree: 2012, Washington State University
URL: http://hdl.handle.net/2376/4099
► A new method of representing positive integers using recurrence sequences, related to tiling a 1 x n board, is developed for recurrences with positive coefficients.…
(more)
▼ A new method of representing positive integers using
recurrence sequences, related to tiling a 1 x n board, is developed for recurrences with positive coefficients. This is then extended to many sequences that have negative coefficients. The densities of individual digits in such representations are then calculated in terms of the dominant root. Finally, we discuss an application of these sequences and representations to cryptography.
Advisors/Committee Members: Webb, William A (advisor).
Subjects/Keywords: Mathematics;
cryptography;
cryptology;
density;
recurrence;
sequence
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APA (6th Edition):
author], [. (2012). Recurrence Representations
. (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/4099
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
author], [No. “Recurrence Representations
.” 2012. Thesis, Washington State University. Accessed February 27, 2021.
http://hdl.handle.net/2376/4099.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
author], [No. “Recurrence Representations
.” 2012. Web. 27 Feb 2021.
Vancouver:
author] [. Recurrence Representations
. [Internet] [Thesis]. Washington State University; 2012. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2376/4099.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
author] [. Recurrence Representations
. [Thesis]. Washington State University; 2012. Available from: http://hdl.handle.net/2376/4099
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queensland University of Technology
17.
Finlayson, Kathleen Joy.
Identification of factors contributing to recurrence of venous leg ulcers.
Degree: 2010, Queensland University of Technology
URL: https://eprints.qut.edu.au/39531/
► Background and Significance Venous leg ulcers are a significant cause of chronic ill-health for 1–3% of those aged over 60 years, increasing in incidence with…
(more)
▼ Background and Significance Venous leg ulcers are a significant cause of chronic ill-health for 1–3% of those aged over 60 years, increasing in incidence with age. The condition is difficult and costly to heal, consuming 1–2.5% of total health budgets in developed countries and up to 50% of community nursing time. Unfortunately after healing, there is a recurrence rate of 60 to 70%, frequently within the first 12 months after heaing. Although some risk factors associated with higher recurrence rates have been identified (e.g. prolonged ulcer duration, deep vein thrombosis), in general there is limited evidence on treatments to effectively prevent recurrence. Patients are generally advised to undertake activities which aim to improve the impaired venous return (e.g. compression therapy, leg elevation, exercise). However, only compression therapy has some evidence to support its effectiveness in prevention and problems with adherence to this strategy are well documented. Aim The aim of this research was to identify factors associated with recurrence by determining relationships between recurrence and demographic factors, health, physical activity, psychosocial factors and self-care activities to prevent recurrence. Methods Two studies were undertaken: a retrospective study of participants diagnosed with a venous leg ulcer which healed 12 to 36 months prior to the study (n=122); and a prospective longitudinal study of participants recruited as their ulcer healed and data collected for 12 months following healing (n=80). Data were collected from medical records on demographics, medical history and ulcer history and treatments; and from self-report questionnaires on physical activity, nutrition, psychosocial measures, ulcer history, compression and other self-care activities. Follow-up data for the prospective study were collected every three months for 12 months after healing. For the retrospective study, a logistic regression model determined the independent influences of variables on recurrence. For the prospective study, median time to recurrence was calculated using the Kaplan-Meier method and a Cox proportional-hazards regression model was used to adjust for potential confounders and determine effects of preventive strategies and psychosocial factors on recurrence. Results In total, 68% of participants in the retrospective study and 44% of participants in the prospective study suffered a recurrence. After mutual adjustment for all variables in multivariable regression models, leg elevation, compression therapy, self efficacy and physical activity were found to be consistently related to recurrence in both studies. In the retrospective study, leg elevation, wearing Class 2 or 3 compression hosiery, the level of physical activity, cardiac disease and self efficacy scores remained significantly associated (p<0.05) with recurrence. The model was significant (p <0.001); with a R2 equivalent of 0.62. Examination of relationships between psychosocial factors and adherence to wearing compression hosiery found wearing…
Subjects/Keywords: venous leg ulcer, recurrence, prevention; ODTA
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APA (6th Edition):
Finlayson, K. J. (2010). Identification of factors contributing to recurrence of venous leg ulcers. (Thesis). Queensland University of Technology. Retrieved from https://eprints.qut.edu.au/39531/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Finlayson, Kathleen Joy. “Identification of factors contributing to recurrence of venous leg ulcers.” 2010. Thesis, Queensland University of Technology. Accessed February 27, 2021.
https://eprints.qut.edu.au/39531/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Finlayson, Kathleen Joy. “Identification of factors contributing to recurrence of venous leg ulcers.” 2010. Web. 27 Feb 2021.
Vancouver:
Finlayson KJ. Identification of factors contributing to recurrence of venous leg ulcers. [Internet] [Thesis]. Queensland University of Technology; 2010. [cited 2021 Feb 27].
Available from: https://eprints.qut.edu.au/39531/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Finlayson KJ. Identification of factors contributing to recurrence of venous leg ulcers. [Thesis]. Queensland University of Technology; 2010. Available from: https://eprints.qut.edu.au/39531/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
18.
陣内, 進也.
Surgical outcomes in cases of postoperative recurrence of primary oral cancer that required reconstruction : 再建術を要した口腔癌術後原発巣再発例の手術成績.
Degree: 博士(医学), 2017, Nagasaki University / 長崎大学
URL: http://hdl.handle.net/10069/37573
► [Purpose] In order to clarify prognostic factors of recurrent oral cancer, [Patients and Methods] In 17 oral cancer patients with their age ranging from 28…
(more)
▼ [Purpose] In order to clarify prognostic factors of recurrent oral cancer, [Patients and Methods] In 17 oral cancer patients with their age ranging from 28 to 86 years old, who underwent extensive resection accompanied by reconstruction for recurrence of a primary oral cancer, correlations between survival rate after salvage surgery and subsite, T classification and N classification of their initial and recurrent tumors, and time of recurrence were analyzed by using Kaplan-Meier method and kai-square analysis. [Results] Tongue cancer (10 patients) was found to have the poorest prognosis among all the subsites, and especially those who had recurrence within 3 months after previous surgery had extremely poor prognoses; 30% (3/10) of them died without being discharged from the hospital after salvage surgery, and in 40% of them QOL was remarkably impaired losing their voice and
chance of peroral food intake, etc. While T classification and N classification of initial and recurrent tumors were found to have
no correlations with the prognosis. [Conclusion] More appropriate and realistic information should be provided to those patients to assist them to make a fully informed decision prior to surgery.
Subjects/Keywords: oral cancer; postoperative recurrence; salvage surgery
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APA (6th Edition):
陣内, . (2017). Surgical outcomes in cases of postoperative recurrence of primary oral cancer that required reconstruction : 再建術を要した口腔癌術後原発巣再発例の手術成績. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/37573
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
陣内, 進也. “Surgical outcomes in cases of postoperative recurrence of primary oral cancer that required reconstruction : 再建術を要した口腔癌術後原発巣再発例の手術成績.” 2017. Thesis, Nagasaki University / 長崎大学. Accessed February 27, 2021.
http://hdl.handle.net/10069/37573.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
陣内, 進也. “Surgical outcomes in cases of postoperative recurrence of primary oral cancer that required reconstruction : 再建術を要した口腔癌術後原発巣再発例の手術成績.” 2017. Web. 27 Feb 2021.
Vancouver:
陣内 . Surgical outcomes in cases of postoperative recurrence of primary oral cancer that required reconstruction : 再建術を要した口腔癌術後原発巣再発例の手術成績. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2017. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10069/37573.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
陣内 . Surgical outcomes in cases of postoperative recurrence of primary oral cancer that required reconstruction : 再建術を要した口腔癌術後原発巣再発例の手術成績. [Thesis]. Nagasaki University / 長崎大学; 2017. Available from: http://hdl.handle.net/10069/37573
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Adelaide
19.
Singh, Kuljit.
Natural history and pathogenesis of Takotsubo cardiomyopathy.
Degree: 2015, University of Adelaide
URL: http://hdl.handle.net/2440/104055
► Introduction: Takotsubo cardiomyopathy (TTC) is a transient left ventricular (LV) systolic dysfunction of uncertain pathogenesis, which occurs predominantly in ageing women. Although there is considerable…
(more)
▼ Introduction: Takotsubo cardiomyopathy (TTC) is a transient left ventricular (LV) systolic dysfunction of uncertain pathogenesis, which occurs predominantly in ageing women. Although there is considerable uncertainty about the pathogenesis of TTC, pronounced catecholamine release and an acute inflammatory process is implicated. Furthermore, natural history of TTC is unknown and correlates of acute complications and incomplete recovery have not been evaluated. Methods: In the 5 experimental chapters, this thesis examines aspects of (a) pathogenesis and (b) natural history of TTC. As regard the pathogenesis, we hypothesized that increased release of nitric oxide (NO) in patients with TTC potentially induces the formation of peroxynitrite (ONOO⁻) anion with associated redox stress, protein nitration and downstream activation of thioredoxin interacting protein (TXNIP). Evaluation of presence of nitrosative stress was performed in a rat model of TTC in parallel with human experiments looking at the local and systemic rise in the 3-nitrotyrosine (3-NT) as a footmark of ONOO⁻ formation. As a part of clinical investigations, we evaluated the role of RV involvement in early hemodynamic derangement. We performed a meta-analysis to assess the impact of “secondary” TTC, male gender, advancing age and catecholamine use on mortality in TTC. We used a similar approach to assess the correlates of
recurrence rate of TTC. Results: A. Pathogenesis: In rat model of TTC, there was substantially increased myocardial 3-NT (2.9 ± 0.6 % and 0.3 ± 0.1 %; p< 0.01) and TXNIP content (16.5 ± 5.2 vs 0.5± 0.2%; p < 0.01). Furthermore, use of poly (ADP) ribose polymerase (PARP)-1 inhibitor attenuated the isoprenaline induced LV systolic dysfunction. In human experiments, plasma concentrations of 3-NT did not differ significantly between TTC (2.26 ± 0.22 nmol/L) and control subjects (2.20 ± 0.25 nmol/L). However, myocardial 3-NT and TxNIP content were increased 4-fold and 10-fold respectively. Furthermore, myocardial content for poly (ADP) ribose (PAR) activity was increased 4 folds. B. Clinical investigations: RV involvement occurred in 1/3rd of TTC patients. Hypotension was noted in 21% of TTC patients, while shock occurred in 16%. RV involvement was a univariate but not a multivariate correlate of either hypotension or shock and did not result in prolonged hospital stay. RV involvement predicted more extensive LV hypokinesis and LV systolic dysfunction. C. Meta-Analysis: In-hospital mortality among patients with TTC was 4.5% (95% CI, 3.1%- 6.2%). Male gender was associated with higher mortality (OR 2.6, 95% CI, 1.5-4.6, p=0.0008) so was “secondary” TTC (RD-0.11, 95%CI; -0.18 to -0.04, p=0.003). TTC had 1-2% annual
recurrence rate, which was independent of clinic utilization of betablocker prescription, but inversely correlated (r =-0.45, p = 0.016) with ACEi/ARB prescription. Patients with severe TTC at index admission were noted to have more recurrences. Conclusion: A. TTC is associated with evidence of nitrosative stress within left ventricular…
Advisors/Committee Members: Horowitz, John David (advisor), Chirkov, Yuliy (advisor), School of Medicine (school).
Subjects/Keywords: Takotsubo cardiomyopathy; nitrosative stress; mortality; recurrence
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Manager
APA (6th Edition):
Singh, K. (2015). Natural history and pathogenesis of Takotsubo cardiomyopathy. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/104055
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Singh, Kuljit. “Natural history and pathogenesis of Takotsubo cardiomyopathy.” 2015. Thesis, University of Adelaide. Accessed February 27, 2021.
http://hdl.handle.net/2440/104055.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Singh, Kuljit. “Natural history and pathogenesis of Takotsubo cardiomyopathy.” 2015. Web. 27 Feb 2021.
Vancouver:
Singh K. Natural history and pathogenesis of Takotsubo cardiomyopathy. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2440/104055.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Singh K. Natural history and pathogenesis of Takotsubo cardiomyopathy. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/104055
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Marmet, Bastien.
Long time behavior of stochastic population models.
Degree: 2014, Université de Neuchâtel
URL: http://doc.rero.ch/record/210275
► L'objectif de cette thèse est l'étude du comportement asymptotique de deux classes de modèles stochastiques de population qui peuvent être vu comme des petites perturbations…
(more)
▼ L'objectif de cette thèse est l'étude du comportement
asymptotique de deux classes de modèles stochastiques de population
qui peuvent être vu comme des petites perturbations aléatoires
d'une dynamique de population déterministe. Le premier de ces deux
modèles est une chaîne de Markov à temps discret qui modélise
l'évolution d'un jeu de population à N joueurs et d types. Le
second modèle est un processus de diffusion sur un compact qui
modélise l'évolution d'un système de population à d espèces avec du
bruit. Ces deux processus modélisent des systèmes de population où,
à l'infini, toutes les espèces sauf une s'éteignent. Ce
travail consiste en l'étude du comportement transitoire de ces
processus avant extinction. Plus précisément on donnera des
résultats concernant les temps d'absorption et les mesures
quasi-stationnaires en reliant le comportement de nos processus
avec celui du système dynamique déterministe qu'ils approximent.
Dans le premier modèle les outils idoines viennent de la théorie
des algorithmes d'approximation stochastiques à pas constant,
tandis que, dans le second cas, notre modèle manquant de
régularité, nous serons amené à prouver des résultats à la
Freidlin-Wentzell.
Advisors/Committee Members: Michel (Dir.).
Subjects/Keywords: Chain Recurrence
…1T <+∞ EXT [f (X)]
Proposition 2.1.6 (Recurrence classes) :
A… …R into equivalence classes for the relation
recurrence classes. A chain where E = R is… …recurrence classes are {C, D, E} and {F, G, H}.
Proposition 2.1.7 :
We have the… …following properties about recurrence classes, let C be a recurrence class
– For all x ∈ C, all y… …else x will be said said to have period k. Every element in a recurrence class has the
same…
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APA ·
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MLA ·
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CSE |
Export
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APA (6th Edition):
Marmet, B. (2014). Long time behavior of stochastic population models. (Thesis). Université de Neuchâtel. Retrieved from http://doc.rero.ch/record/210275
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Marmet, Bastien. “Long time behavior of stochastic population models.” 2014. Thesis, Université de Neuchâtel. Accessed February 27, 2021.
http://doc.rero.ch/record/210275.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Marmet, Bastien. “Long time behavior of stochastic population models.” 2014. Web. 27 Feb 2021.
Vancouver:
Marmet B. Long time behavior of stochastic population models. [Internet] [Thesis]. Université de Neuchâtel; 2014. [cited 2021 Feb 27].
Available from: http://doc.rero.ch/record/210275.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Marmet B. Long time behavior of stochastic population models. [Thesis]. Université de Neuchâtel; 2014. Available from: http://doc.rero.ch/record/210275
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Univerzitet u Beogradu
21.
Medić, Sanja D., 1967-.
Prognostička studija akutnog ishemijskog moždanog
udara.
Degree: Medicinski fakultet, 2013, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:5549/bdef:Content/get
► Medicina - Neurologija / Medicine - Neurology
Iako je akutni ishemijski moţdani udar (AIMU) jedan od vodećih uzroka obolevanja, invaliditeta i umiranja u populaciji Beograda,…
(more)
▼ Medicina - Neurologija / Medicine -
Neurology
Iako je akutni ishemijski moţdani udar (AIMU) jedan
od vodećih uzroka obolevanja, invaliditeta i umiranja u populaciji
Beograda, podaci o prognostičkim karakteristikama ove bolesti su
gotovo nepoznati. Identifikovanje najznačajnijih faktora koji utiču
na preţivljavanje, rizik od invaliditeta i recidiva značajno je za
planiranje duţine lečenja i rehabilitacije, kreiranje optimalnih
dijagnostičkih, terapijskih i preventivnih strategija, kao i za
organizaciju odgovarajućih grana zdravstvene sluţbe. Ciljevi rada
su bili: procena stopa preţivljavanja bolesnika sa prvim AIMU,
procena stopa fatalnosti AIMU u prvih 28 dana i nakon 1. godine
praćenja, procena stopa recidiva AIMU, funkcionalnog statusa
bolesnika koji preţive AIMU i prognostičkog značaja odabranih
varijabli. Prospektivna kohortna studija obuhvatila je 300
bolesnika sa prvim AIMU, koji su se sukcesivno javljali u periodu
od mesec dana (2008. godine) u dve glavne neurološke ustanove za
lečenje moţdanog udara u Beogradu (Odeljenje Urgentne neurologije
Klinike za neurologiju, KCS, i Specijalna bolnica za prevenciju i
lečenje cerebrovaskularnih bolesti ''Sveti Sava''). Kod svih
pacijenata je pri prijemu primenjen standardizovan dijagnostički
protokol koji je obuhvatao prikupljanje svih relevantnih podataka,
uključujući informacije o sociodemiografskim karakteristikama i
vaskularnim faktorima rizika, neurološki i internistički pregled,
uzimanje uzoraka krvi za laboratorijske analize i CT ili MR pregled
endokranijuma. Za razmatranje etiologije od značaja su bile i
neurovaskularne dijagnostičke metode kao i ehokardiografija. Teţina
AIMU je odreĎena prema NIHSS skali, a stepen funkcionalne
zavisnosti i invaliditeta na osnovu modifikovanog Rankinovog skora
(mRS) i Barthel indexa (BI). Za odreĎivanje tipa AIMU primenjena je
etiopatogenetska TOAST klasifikacija. Informacije o ishodu
prikupljene su posle prvih 28 dana i po završetku prve godine
praćenja. Posle godinu dana od nastanka AIMU ponovo je procenjen
funkcionalni status bolesnika, na osnovu mRS i BI.
..
Advisors/Committee Members: Pekmezović, Tatjana, 1964-.
Subjects/Keywords: stroke; prognosis; mortality; recurrence; functional
recovery
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APA (6th Edition):
Medić, Sanja D., 1. (2013). Prognostička studija akutnog ishemijskog moždanog
udara. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:5549/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Medić, Sanja D., 1967-. “Prognostička studija akutnog ishemijskog moždanog
udara.” 2013. Thesis, Univerzitet u Beogradu. Accessed February 27, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:5549/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Medić, Sanja D., 1967-. “Prognostička studija akutnog ishemijskog moždanog
udara.” 2013. Web. 27 Feb 2021.
Vancouver:
Medić, Sanja D. 1. Prognostička studija akutnog ishemijskog moždanog
udara. [Internet] [Thesis]. Univerzitet u Beogradu; 2013. [cited 2021 Feb 27].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:5549/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Medić, Sanja D. 1. Prognostička studija akutnog ishemijskog moždanog
udara. [Thesis]. Univerzitet u Beogradu; 2013. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:5549/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Boston University
22.
Torres, Alexandra.
Dietary and lifestyle modifications in the prevention of epithelial ovarian cancer recurrence.
Degree: MS, Physician Assistant Program, 2017, Boston University
URL: http://hdl.handle.net/2144/26949
► BACKGROUND: Advanced stage epithelial ovarian cancer (EOC) presents with an extremely poor prognosis. While some patients respond well to standard treatments of chemotherapy and cytoreductive…
(more)
▼ BACKGROUND: Advanced stage epithelial ovarian cancer (EOC) presents with an extremely poor
prognosis. While some patients respond well to standard treatments of chemotherapy and
cytoreductive surgery, the recurrence rate is high and five-year survival is low. The
importance of nutritional eating and a healthy lifestyle has been recognized as a
protective factor against the development of many cancers. There may be a role for
dietary and lifestyle interventions on reducing the recurrence of EOC, thereby prolonging
survival.
LITERATURE REVIEW FINDINGS: A review of the literature was performed, focusing on dietary and lifestyle patterns and
their effects on the development and recurrence of epithelial ovarian cancers. In general,
carotenoids, flavonoids, cruciferous vegetables, and flaxseed rich diets have all been
proposed to reduce the risk of developing ovarian cancer. Conversely, red and processed
meats, and foods with high glycemic index have been associated with an increased risk of
ovarian cancer development. Additionally, obesity and high Body Mass Index (BMI)
have been linked to increased cancer risk as well as increased mortality rates from cancer.
PROPOSE METHODS: Given the broad spectrum of dietary and lifestyle recommendations for prevention of
EOC, many providers are not aware of what information they can give to their patients
regarding this topic. A Continuing Medical Education (CME) lecture summarizing the
most up-to-date literature on the topic of lifestyle interventions to increase EOC survival
would be beneficial. A one hour long course will be offered for CME credit to expand the
knowledge base of providers and equip them with the resources necessary to educate
patients on healthy lifestyle modifications in order to minimize ovarian cancer
recurrence.
CONCLUSIONS: With a lack of definitive cure and poor overall prognosis for women diagnosed with
advanced stage epithelial ovarian cancer, there is a need for alternative treatment options
when traditional methods fail. There is promising evidence that a diet high in carotenoids,
cruciferous vegetables, flaxseed, and several other nutritional components is beneficial in
preventing development of ovarian cancer. A diet containing processed foods, red meats,
dairy, and high sugar content has been associated with increased ovarian cancer risk. It is
possible that these dietary recommendations may apply to prevention of recurrence of
EOC as well. The CME lecture will present the most up-to-date knowledge in the area of
lifestyle interventions for the prevention of EOC. A curriculum for primary care and
oncology health care providers will provide them with the tools necessary to provide their
patients with nutrition and lifestyle recommendations that may prevent cancer recurrence.
Subjects/Keywords: Oncology; Llifestyle; Nutrition; Ovarian cancer; Prevention; Recurrence
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Manager
APA (6th Edition):
Torres, A. (2017). Dietary and lifestyle modifications in the prevention of epithelial ovarian cancer recurrence. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/26949
Chicago Manual of Style (16th Edition):
Torres, Alexandra. “Dietary and lifestyle modifications in the prevention of epithelial ovarian cancer recurrence.” 2017. Masters Thesis, Boston University. Accessed February 27, 2021.
http://hdl.handle.net/2144/26949.
MLA Handbook (7th Edition):
Torres, Alexandra. “Dietary and lifestyle modifications in the prevention of epithelial ovarian cancer recurrence.” 2017. Web. 27 Feb 2021.
Vancouver:
Torres A. Dietary and lifestyle modifications in the prevention of epithelial ovarian cancer recurrence. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2144/26949.
Council of Science Editors:
Torres A. Dietary and lifestyle modifications in the prevention of epithelial ovarian cancer recurrence. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/26949
University of Gothenburg / Göteborgs Universitet
23.
Sundberg, Jonas.
Oral leukoplakia, human papillomavirus and cancer transformation.
Degree: 2020, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/66194
► Oral leukoplakia (OL) is clinically diagnosed as a white oral lesion that cannot be scraped of or diagnosed as any other type of oral lesion.…
(more)
▼ Oral leukoplakia (OL) is clinically diagnosed as a white oral lesion that cannot be scraped of or diagnosed as any other type of oral lesion. OL has the potential to transform into oral squamous cell carcinoma (OSCC). The gold standard treatment is a combination of surgical excision if possible, and surveillance. Despite complete removal, the risk of cancer or recurrence remains high. A major clinical problem is to predict which patients that have an OL that turns into OSCC. Infection with human papillomavirus (HPV), especially high risk (HR) HPV types has been attributed a role in cancer transformation of OL. HPV is a ubiquitous virus transmissible between humans and with a global variation in prevalence and known to cause cancer of the cervix uteri but also an important factor in oropharyngeal cancer. The overall aim of this thesis was to investigate the influence of HPV infection in OL, which clinical-, histopathological and treatment factors that affect the recurrence rate after surgical removal and to investigate molecular markers connected to cell proliferation and cancer transformation.
The thesis is based on five scientific questions addressed in four different studies:
Study I: Is there a correlation between overexpression of the tumour suppressor protein p16 and high-risk HPV infection in leukoplakia and OSCC? In this study the level expression of p16 in OL was assessed by immunohistochemistry and in the same group of patients OL tissue samples were analysed by Real-Time polymerase chain reaction (RT-PCR) for presence of twelve high-risk and two low-risk HPV types. In parallel, p16-expressing OSCC were analysed for the same HPV types.
Study II: Has the prevalence of high-risk HPV in leukoplakia changed over time? Does the prevalence differ between Sweden, Romania and Brazil? In contemporary and historical patient cohorts from the three countries OL samples were analysed with RT-PCR for 12 high-risk and two low-risk HPV types. In patients with cancer transformation of their OL tumour samples were also screened for presence of the same HPV types.
Study III: Which clinical and anamnestic factors correlate with the recurrence of leukoplakia after surgical removal? Patients with OL that were surgically removed comprised the study cohort. At inclusion anamnestic and clinical factors were registered together with results of the histopathological examination. Study subjects underwent follow-up visits at 3-6 months post-surgery according to the study protocol. Recurrence was defined as reappearance of OL at the primary lesion site.
Study IV: Can expression of the cell proliferation biomarkers p53, p63, podoplanin and Ki-67 predict the recurrence of leukoplakia after surgical excision? In this study patients with recurring vs non-recurring OL were compared regarding molecules known to be part of or influence cycle regulation. Immunohistochemistry was utilized and cell quantification was performed on digitalised images.
The results showed that:
• A high expression level of the tumour suppressor protein p16 is not…
Subjects/Keywords: potentially malignant oral disorders; HPV; recurrence
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APA (6th Edition):
Sundberg, J. (2020). Oral leukoplakia, human papillomavirus and cancer transformation. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/66194
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sundberg, Jonas. “Oral leukoplakia, human papillomavirus and cancer transformation.” 2020. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 27, 2021.
http://hdl.handle.net/2077/66194.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sundberg, Jonas. “Oral leukoplakia, human papillomavirus and cancer transformation.” 2020. Web. 27 Feb 2021.
Vancouver:
Sundberg J. Oral leukoplakia, human papillomavirus and cancer transformation. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2077/66194.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sundberg J. Oral leukoplakia, human papillomavirus and cancer transformation. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. Available from: http://hdl.handle.net/2077/66194
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of South Florida
24.
Lucas, Jean Marie.
Factors Associated with Fear of Breast Cancer Recurrence Among Survivors.
Degree: 2013, University of South Florida
URL: https://scholarcommons.usf.edu/etd/4720
► The purpose of this cross-sectional, secondary data analysis was to explore, non-modifiable (stable) trait factors and modifiable (transient) state factors associated with fear of recurrence…
(more)
▼ The purpose of this cross-sectional, secondary data analysis was to explore, non-modifiable (stable) trait factors and modifiable (transient) state factors associated with fear of recurrence (FOR) in breast cancer survivors. Antecedent trait factors included demographic, clinical, social/behavioral factors, postulated mediator state factors included pain, fatigue, sleep disturbances, depression, state anxiety and perceived stress, and FOR was the outcome variable. The study used baseline data from an R-21 NCI funded (grantR21CA109168) randomized control trial that examined the effects of mindfulness based stress reduction in early stage breast cancer recovery. Instruments from this study for antecedent variables (trait factors) included a Demographic and Clinical History Form, STAI; instruments used for mediator variable (state factors) included CES-D, STAI, PSS and MDASI subscales for pain and fatigue, sleep; the instruments used for the outcome variable FOR - CARS overall fear and nature of worry. The study sample included 82 women within 18 months post breast cancer treatment (stage 0, I, II, III). The Theoretical Model for psychosocial nursing research was used as a heuristic framework to examine the associations between trait factors and state factors and their mediating effects on FOR. Aim 1 explored the relationship between the antecedent (trait) variables associated with FOR (CARS overall fear and CARS nature of worry) using Pearson's and Spearman's correlations and analysis of variance (ANOVA). The findings revealed a negative association between age and FOR, CARS overall fear (r = -.236, p = .033) and FOR, CARS nature of worry (r = -.269, p = .015). Trait anxiety was positively associated with FOR, CARS overall fear (r = .433, p = .000) and FOR, CARS nature of worry (r = .358, p < 0.001). Race/ethnicity, education, marital status, employment, exercise, cancer stage, cancer treatment, exercise, smoking, drinking, hormone use and family history of breast cancer were not associated with FOR. Aim 2 explored the relationship between postulated mediator (state) variables, such as pain, fatigue, sleep disturbances, state anxiety, depression, perceived stress associated with FOR (CARS overall fear and CARS nature of worry) using Pearson's correlations. Findings revealed that depression (r = .347, p = .001), state anxiety (r = .467, p < 0.001), perceived stress (r = .365, p = .001) were positively associated with FOR, CARS overall fear of recurrence, and that pain (r = .220, p = .047), fatigue (r = .247, p = .025), state anxiety (r = .369, p = .001), and perceived stress (r = .410, p < 0.001) were positively associated with FOR, CARS nature of worry. Aim 3 used a mediation analysis (bootstrapping method) to examine the indirect effects of the statistically significant modifiable mediator state factors on the statistically significant antecedent trait factors and FOR (CARS overall fear and CARS nature of worry). With trait anxiety as the antecedent variable, state anxiety was indirectly associated (a mediating…
Subjects/Keywords: Breast; Cancer; Fear; Recurrence; Survivorship; Nursing; Oncology
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APA (6th Edition):
Lucas, J. M. (2013). Factors Associated with Fear of Breast Cancer Recurrence Among Survivors. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/4720
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lucas, Jean Marie. “Factors Associated with Fear of Breast Cancer Recurrence Among Survivors.” 2013. Thesis, University of South Florida. Accessed February 27, 2021.
https://scholarcommons.usf.edu/etd/4720.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lucas, Jean Marie. “Factors Associated with Fear of Breast Cancer Recurrence Among Survivors.” 2013. Web. 27 Feb 2021.
Vancouver:
Lucas JM. Factors Associated with Fear of Breast Cancer Recurrence Among Survivors. [Internet] [Thesis]. University of South Florida; 2013. [cited 2021 Feb 27].
Available from: https://scholarcommons.usf.edu/etd/4720.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lucas JM. Factors Associated with Fear of Breast Cancer Recurrence Among Survivors. [Thesis]. University of South Florida; 2013. Available from: https://scholarcommons.usf.edu/etd/4720
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
25.
Mask, Kyle Evan.
Eternal recurrence and nature.
Degree: MA, Philosophy, 2008, Texas A&M University
URL: http://hdl.handle.net/1969.1/86057
► Nietzsche has often been interpreted as the champion of heroic, self-sufficient individuals, who manage to fashion some order out of the raw material of Nature…
(more)
▼ Nietzsche has often been interpreted as the champion of heroic, self-sufficient
individuals, who manage to fashion some order out of the raw material of Nature
through the exercise of free will. On the face of things, Nietzsche's doctrine of eternal
recurrence creates a problem for such an interpretation. If history must eternally repeat
itself, then it can take only one possible route. Individuals' future actions would then be
constrained by the sole possible path of history, and free will would seem to be
undermined.
In order to avoid the conclusion that eternal
recurrence obviates free will,
scholars have attempted to show that: (1) Nietzsche does not wish to establish a link
between eternal
recurrence and cosmology - that is, eternal
recurrence should not be
read as the cyclical repetition of history; (2) eternal
recurrence can be construed so that it
aggrandizes the importance of free choice. Contrary to these two trends in scholarship
about eternal
recurrence, I believe that Nietzsche intends to draw a connection between
eternal
recurrence and cosmology, and this connection undermines free will. In order to
establish this, I examine the textual evidence on eternal
recurrence from The Gay Science and Zarathustra to show that Nietzsche employs eternal
recurrence as a
metaphor for determinism in those works. As a metaphor for a deterministic cosmos,
eternal
recurrence undercuts free will. Turning to Nietzsche's late works, I show that
Nietzsche broadens the scope of eternal
recurrence. Eternal
recurrence comes to serve
as a metaphor for the Dionysian character of Nature. Only by relinquishing one's desire
for free will and submitting to necessity and to the trans-individual potency of Nature
can the individual see herself as powerful. Hence, it is argued that Nietzsche does not
believe individuals manifest strength by asserting their free wills against Nature, as
commentators often maintain. Instead, Nietzsche enjoins individuals to cede their
desires for free will and to participate in the trans-individual vitality of Nature.
Advisors/Committee Members: Conway, Daniel (advisor), Swift, Christopher (committee member), George, Theodore (committee member).
Subjects/Keywords: Eternal; Recurrence
…his doctrine of
eternal recurrence. He believes that affirming eternal recurrence signifies… …traditionally
attempted to show three things about eternal recurrence. The first is that it does not… …recurs in precisely the same pattern. If proven that Nietzsche does not
propound a recurrence… …recurrence,” namely, “that we have no reason to
accept its truth.”5 In an effort to save Nietzsche… …discusses eternal recurrence
commits him to a recurrence cosmology. Similarly, in order to provide…
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APA (6th Edition):
Mask, K. E. (2008). Eternal recurrence and nature. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/86057
Chicago Manual of Style (16th Edition):
Mask, Kyle Evan. “Eternal recurrence and nature.” 2008. Masters Thesis, Texas A&M University. Accessed February 27, 2021.
http://hdl.handle.net/1969.1/86057.
MLA Handbook (7th Edition):
Mask, Kyle Evan. “Eternal recurrence and nature.” 2008. Web. 27 Feb 2021.
Vancouver:
Mask KE. Eternal recurrence and nature. [Internet] [Masters thesis]. Texas A&M University; 2008. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1969.1/86057.
Council of Science Editors:
Mask KE. Eternal recurrence and nature. [Masters Thesis]. Texas A&M University; 2008. Available from: http://hdl.handle.net/1969.1/86057
26.
Grevenstein, W.M.U.
Surgery and Peritoneal Tumor Recurrence: pathways studies 'in vitro'.
Degree: 2007, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/10433
► De incidentie van colon carcinomen (kwaadaardige tumoren van de dikke darm) neemt toe in de westerse wereld. In Europa wordt jaarlijks bij 400 000 patiënten…
(more)
▼ De incidentie van colon carcinomen (kwaadaardige tumoren van de dikke darm) neemt
toe in de westerse wereld. In Europa wordt jaarlijks bij 400 000 patiënten dikke darm
kanker vastgesteld en overlijden er jaarlijks 200 000 patiënten met deze vorm van
kanker. Van alle vormen van kanker staan colon carcinomen met een incidentie van 14%
op de derde plaats na long- en prostaatkanker. De overall 5-jaarsoverleving is ongeveer
60-70%, indien er sprake is van lokale uitzaaiing (lokaal recidief) daalt de 5-jaarsoverleving
naar 35% en bij uitzaaiingen in andere organen (metastasen) naar 25%.
Kwaadaardige tumoren van de alvleesklier (pancreas) hebben een zeer slechte prognose.
Na chirurgische resectie zal meer dan 50% van de patiënten een metastase
ontwikkelen. Minder dan 15% van de patiënten met een pancreas carcinoom overleeft
het eerste jaar en de 5-jaarsoverleving is kleiner dan 5%.
De behandeling van keuze bij colon of pancreas carcinomen is chirurgische resectie.
Het nadeel van deze chirurgische behandeling is dat tijdens de operatie tumorcellen
kunnen los raken door manipulatie van de primaire tumor (‘spilled tumour cells’). Deze
tumorcellen kunnen aanhechten op het resetievlak of op een andere plaats in de buik en
op deze manier uitgroeien tot een recidief tumor. Bij zowel colon als pancreas carcinomen
komt lokaal tumor recidief vaak voor. Daarom is kennis van het ontstaan van lokaal
tumor recidief zeer belangrijk. Dit proces kan uitgesplitst worden in tumorcel aanhechting
en tumor groei. Het proces van aanhechting van een tumorcel is afhankelijk van een
groot aantal factoren. De experimenten beschreven in dit proefschrift bestuderen het
proces van aanhechting van de tumorcel en de invloed van factoren, die postoperatief
intra-abdominaal (in de buik) worden geproduceerd op deze aanhechting.
Subjects/Keywords: surgery; tumor recurrence
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Export
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APA (6th Edition):
Grevenstein, W. M. U. (2007). Surgery and Peritoneal Tumor Recurrence: pathways studies 'in vitro'. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/10433
Chicago Manual of Style (16th Edition):
Grevenstein, W M U. “Surgery and Peritoneal Tumor Recurrence: pathways studies 'in vitro'.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed February 27, 2021.
http://hdl.handle.net/1765/10433.
MLA Handbook (7th Edition):
Grevenstein, W M U. “Surgery and Peritoneal Tumor Recurrence: pathways studies 'in vitro'.” 2007. Web. 27 Feb 2021.
Vancouver:
Grevenstein WMU. Surgery and Peritoneal Tumor Recurrence: pathways studies 'in vitro'. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1765/10433.
Council of Science Editors:
Grevenstein WMU. Surgery and Peritoneal Tumor Recurrence: pathways studies 'in vitro'. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/10433
Universiteit Utrecht
27.
Grimm, R.M.
Assessing the impact of frequency and local adaptation mechanisms on child-caregiver language: a recurrence-quantificational approach.
Degree: 2014, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/296351
► The degree to which the prevalence of words and syntactic structures in child-caregiver language is influenced by (1) their frequency in the other interlocutor's speech…
(more)
▼ The degree to which the prevalence of words and syntactic structures in child-caregiver language is influenced by (1) their frequency in the other interlocutor's speech and (2) their involvement in local adaptation processes is investigated. Utilizing the relatively novel technique of
recurrence-quantificational analysis, quantitative measures are constructed in order to tease apart and independently measure the impact of these two factors. Three corpora from the CHILDES database reveal that within both child and caregiver speech, the frequency of most words and syntactic structures is more strongly determined by their frequency in the other interlocutor's speech. However, this changes when considering only high-frequency words and structures, where local adaption mechanisms appear to exert a stronger influence on usage. Across corpora and interlocutors, there is both variance and remarkable homogeneity in how usage is affected.
Advisors/Committee Members: Fernández, R., Nouwen, R.W.F., Meroni, L..
Subjects/Keywords: recurrence-quantificational analysis; recurrence plots; child-caregiver dialogue; local adaptation; convergence; child-directed speech
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APA ·
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APA (6th Edition):
Grimm, R. M. (2014). Assessing the impact of frequency and local adaptation mechanisms on child-caregiver language: a recurrence-quantificational approach. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/296351
Chicago Manual of Style (16th Edition):
Grimm, R M. “Assessing the impact of frequency and local adaptation mechanisms on child-caregiver language: a recurrence-quantificational approach.” 2014. Masters Thesis, Universiteit Utrecht. Accessed February 27, 2021.
http://dspace.library.uu.nl:8080/handle/1874/296351.
MLA Handbook (7th Edition):
Grimm, R M. “Assessing the impact of frequency and local adaptation mechanisms on child-caregiver language: a recurrence-quantificational approach.” 2014. Web. 27 Feb 2021.
Vancouver:
Grimm RM. Assessing the impact of frequency and local adaptation mechanisms on child-caregiver language: a recurrence-quantificational approach. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2021 Feb 27].
Available from: http://dspace.library.uu.nl:8080/handle/1874/296351.
Council of Science Editors:
Grimm RM. Assessing the impact of frequency and local adaptation mechanisms on child-caregiver language: a recurrence-quantificational approach. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/296351
University of Toronto
28.
Berger-Richardson, David.
Surgical Gloves and Instruments: Potential Vectors of Cancer Cell Seeding.
Degree: 2017, University of Toronto
URL: http://hdl.handle.net/1807/76651
► Cancer recurrence in surgical wounds occurs by unknown mechanisms. My hypothesis is that tumour cells are harboured on surgical gloves and instruments during the extirpative…
(more)
▼ Cancer recurrence in surgical wounds occurs by unknown mechanisms. My hypothesis is that tumour cells are harboured on surgical gloves and instruments during the extirpative phase of a cancer resection and can exfoliate into the wound during reconstruction, with potential for growth. A systematic review revealed that the incidence of port-site metastasis in gallbladder cancer is especially high. A survey of practising surgeons found that there is no consensus as to whether specific intraoperative protective strategies are warranted. An analysis of washings from gloves and instruments used intraoperatively during cancer resections identified malignant cells on approximately half of gloves and instruments that had directly handled malignant tissue (debulking of peritoneal malignancy, incisional biopsy of extremity sarcoma). No malignant cells were identified on a glove or instrument used in margin-negative sarcoma resection. These results suggest that specific protective strategies may not be warranted in curative resections.
M.Sc.
Advisors/Committee Members: Swallow, Carol J, Medical Science.
Subjects/Keywords: cancer seeding; mechanisms of seeding; surgical oncology; tumour recurrence; wound recurrence; 0576
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APA (6th Edition):
Berger-Richardson, D. (2017). Surgical Gloves and Instruments: Potential Vectors of Cancer Cell Seeding. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/76651
Chicago Manual of Style (16th Edition):
Berger-Richardson, David. “Surgical Gloves and Instruments: Potential Vectors of Cancer Cell Seeding.” 2017. Masters Thesis, University of Toronto. Accessed February 27, 2021.
http://hdl.handle.net/1807/76651.
MLA Handbook (7th Edition):
Berger-Richardson, David. “Surgical Gloves and Instruments: Potential Vectors of Cancer Cell Seeding.” 2017. Web. 27 Feb 2021.
Vancouver:
Berger-Richardson D. Surgical Gloves and Instruments: Potential Vectors of Cancer Cell Seeding. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1807/76651.
Council of Science Editors:
Berger-Richardson D. Surgical Gloves and Instruments: Potential Vectors of Cancer Cell Seeding. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/76651
Freie Universität Berlin
29.
Vogel, Nina.
Results of curativ surgery of rectal cancer.
Degree: 2014, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-6210
► Colorectal cancer is the second most frequent cancer. Diagnostic and therapy has experienced an enormous change in the last decades. With the total mesorectal excision…
(more)
▼ Colorectal cancer is the second most frequent cancer. Diagnostic and therapy
has experienced an enormous change in the last decades. With the total
mesorectal excision an optimized technique of operation was developed and also
the adjuvant therapy was changed in the last decades. Thus lower local
recurrence rates and better survival dates were possible. Aim of this study
was to review local
recurrence rates and survival data of our own patients and
to compare the results with the current data in literature. The data of 135
patients who underwent surgery of rectal cancer at the Department of General,
Vascular and Thoracic Surgery, Charité Berlin, Campus Benjamin Franklin, from
1995 to 2002 were analyzed. After the description of the pre-, intra- and
post-operative data the follow-up data was analyzed regarding
recurrence and
survival rates and prognostic factors were detected. The
recurrence rate after
2 years was 11.2% and after 5 years 29.9%. The 2-years-rate of local
recurrence was 5.3% and the 5-years-local-
recurrence-rate was 14.9%. The 2
-years-rate of distant metastasis was 10.5% and the 5-years rate was 23.7%.
The overall survival rate was 90.8% after 2 years and 74.7% after 5 years.
Age, UICC-Stade, gender, operation-method and adjuvant therapy were detected
as prognostic factors. The
recurrence-free survival rate was 84.6% after 2
years and 65.8% after 5 years. UICC-Stade, age and gender were prognostic
factors. The local
recurrence-free survival rate was 93.7% after 2 years and
82.6% after 5 years. Operation-method, age and UICC- Stade were found as
prognostic factors. The distant metastasis-free survival rate after 2 years
was 87.6% and after 5 years 73.7%. Only the UICC-Stade was perceived as a
prognostic factor. The analysis showed that short- and long-term results of
this study are comparable with the data of current literature. Further factors
like circumferential margin and the surgeon himself are described in current
literature as prognostic factors. The analysis of these factors need further
own studies. Due to the enormous change of the multimodal therapy, lower
recurrence and better survival rates could be achieved. Although the patients
in this study were treated with an adjuvant radiochemotherapy, the results
were comparable to those of the current literature with a neoadjuvant
radiochemotherapy. Due to significant side effects like the low anterior
resection syndrome (LARS) and lower life quality it is advisable to select the
patients carefully.
Advisors/Committee Members: w (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: rectal cancer; recurrence; local recurrence; survival; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
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APA (6th Edition):
Vogel, N. (2014). Results of curativ surgery of rectal cancer. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6210
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vogel, Nina. “Results of curativ surgery of rectal cancer.” 2014. Thesis, Freie Universität Berlin. Accessed February 27, 2021.
http://dx.doi.org/10.17169/refubium-6210.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vogel, Nina. “Results of curativ surgery of rectal cancer.” 2014. Web. 27 Feb 2021.
Vancouver:
Vogel N. Results of curativ surgery of rectal cancer. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Feb 27].
Available from: http://dx.doi.org/10.17169/refubium-6210.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vogel N. Results of curativ surgery of rectal cancer. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-6210
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Lund
30.
Sevonius, Dan.
Recurrent groin hernia - Outcome after surgery.
Degree: 2014, University of Lund
URL: https://lup.lub.lu.se/record/4778912
;
https://portal.research.lu.se/ws/files/3914383/4778913.pdf
► Background: According to the Swedish Hernia Register (SHR), the reoperation rate after recurrent groin hernia is more than twice that following primary hernia repair. Aims:…
(more)
▼ Background: According to the Swedish Hernia
Register (SHR), the reoperation rate after recurrent groin hernia
is more than twice that following primary hernia repair. Aims: To
study the impact of method of mesh repair used in recurrent groin
hernia surgery on re-recurrence as well as chronic pain and
physical disability. Methods: Papers 1 and 2 were based on
nationwide data from the SHR 1992-2008. In Paper 1 the cumulative
risk for reoperation was studied after repeated surgery for
recurrent hernia. In Paper 2 the risk for reoperation was analysed
in relation to the mesh method used for recurrent hernia repair,
taking the previous (index) repair into account. Papers 3 and 4
were based on a cohort of 1st and 2nd recurrent repairs performed
at 5 hospitals in the south-west region of Sweden 1998-2007. A
follow-up was performed 2009 using the Inguinal Pain Questionnaire
(IPQ) and a selective clinical examination. In Paper 3 the risk for
a 2nd recurrence was studied in relation to Anterior (AMR) and
Posterior Mesh Repairs (PMR) and in Paper 4 the hazard ratio for
chronic pain and physical disability was studied in relation to
type of mesh repair and mean surgeon´s annual volume. Results:
Paper 1 The risk for a further reoperation increased with the
number of recurrent repairs (p<0.001). Paper 2 Endoscopic
(E-PMR) and open PMR (O-PMR) were associated with the lowest risk
for reoperation when the index repair was an anterior repair
(p<0.001) Paper 3. PMR was associated with a decreased 2nd
recurrence rate compared with AMR (p=0.025). An increased risk for
a subsequent 2nd recurrence was seen an after anterior index repair
followed by an AMR (HR 3.21 (CI 1.33-7.44), p=0.009)) and a
decreased risk after posterior index repair followed by an AMR (HR
0.08 (CI 0.01-0.94), p=0.045). In the O-PMR group there was a lower
2nd recurrence rate after a Nyhus approach (2.5 %) compared to a
trans inguinal approach (TIPP) (28 %) (p=0.001). A mean surgeon´s
annual volume ≤ 5 O-PMR resulted in a higher risk for a 2nd
recurrence (p<0.001). Paper 4 The E-PMR was associated with a
lower risk for chronic pain and physical disability compared to
AMR, after a previous anterior index repair (OR 0.54 (CI
0.30-0.97), p=0.039). A mean surgeon´s annual volume > 5 O-PMR
correlated with a lower risk for chronic pain compared to an
surgeon´s annual volume ≤ 5 (OR 0.42 (CI 0.19-0.94), p=0.034).
Having a 2nd recurrent repair was associated with a higher risk for
chronic pain compared to a 1st recurrent repair (OR 2.89 (CI
1.21-6.88), p=0.017). Conclusions: A posterior mesh repair for
recurrent groin hernia surgery was associated with a lower 2nd
recurrence rate compared to anterior mesh repair. A posterior mesh
repair for the 1st recurrent operation is recommended after an
anterior index repair and an anterior mesh repair after a posterior
index operation. Endoscopic repairs have the lowest risk for both a
2nd recurrence and chronic groin pain and physical disability. An
O-PMR performed trough a Nyhus incision is preferred and the TIPP
procedure should be…
Subjects/Keywords: Surgery; Groin hernia; inguinal hernia; recurrence; re-recurrence; mesh repair; chronic pain; hernia register
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APA (6th Edition):
Sevonius, D. (2014). Recurrent groin hernia - Outcome after surgery. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/4778912 ; https://portal.research.lu.se/ws/files/3914383/4778913.pdf
Chicago Manual of Style (16th Edition):
Sevonius, Dan. “Recurrent groin hernia - Outcome after surgery.” 2014. Doctoral Dissertation, University of Lund. Accessed February 27, 2021.
https://lup.lub.lu.se/record/4778912 ; https://portal.research.lu.se/ws/files/3914383/4778913.pdf.
MLA Handbook (7th Edition):
Sevonius, Dan. “Recurrent groin hernia - Outcome after surgery.” 2014. Web. 27 Feb 2021.
Vancouver:
Sevonius D. Recurrent groin hernia - Outcome after surgery. [Internet] [Doctoral dissertation]. University of Lund; 2014. [cited 2021 Feb 27].
Available from: https://lup.lub.lu.se/record/4778912 ; https://portal.research.lu.se/ws/files/3914383/4778913.pdf.
Council of Science Editors:
Sevonius D. Recurrent groin hernia - Outcome after surgery. [Doctoral Dissertation]. University of Lund; 2014. Available from: https://lup.lub.lu.se/record/4778912 ; https://portal.research.lu.se/ws/files/3914383/4778913.pdf
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