subject:(Realtime Intraopeative PET Imaging)

1. Huh, Sam Seoung. Preliminary Study of an Intra-operative PET Imaging Probe System.

Degree: PhD, Biomedical Engineering, 2011, University of Michigan

URL: http://hdl.handle.net/2027.42/86331

► PET imaging has gained widespread acceptance in cancer imaging because Positron Emission Tomography can identify physiological changes due to cancer. Nevertheless conventional PET imaging has… (more)

▼ PET imaging has gained widespread acceptance in cancer imaging because Positron Emission Tomography can identify physiological changes due to cancer. Nevertheless conventional PET imaging has difficulty detecting tumors less than 1cm in diameter in clinical use due mainly to background radiation, statistical noise, resolution loss due to lack of depth interaction resolution in detectors, and annihilation photon acolinearity. Conventionally if detected tumors are surgically removable, surgeons locate and remove the tumors during surgery based on the preoperative scans. One of the drawbacks of relying solely on preoperative imaging is that tumor locations could be displaced during surgery due to patient’s movement. In this dissertation, a preliminary study of an intra-operative PET imaging probe system is presented. The proposed probe system consists of a low resolution partial ring detector and a high resolution imaging probe that is equipped with a position tracker. The high resolution probe operates in coincidence with the partial ring detector. The high resolution imaging probe and its proximity to target lesions contribute to the localization of small tumors. In addition, the probe system can be used to detect occult tumors. The ultimate goal is to provide incremental 3-dimensional reconstructed images that are re-projected in real time onto a plane whose orientation is driven by the tracking device. A prototype of the PET imaging probe system was built to test the feasibility of the intra-operative PET imaging probe system. Coincidence detection efficiency of about 0.00012% was observed. A variant of 3-dimensional one-pass list-mode maximum likelihood algorithm (OP-LML) was developed to reconstruct images from the measured data. A row-action maximum likelihood algorithm was integrated with the OP-LML. To speed up image reconstruction by a factor of 30-40, the proposed algorithm was parallelized and was run on a graphics processing unit. Reconstructed images from simulated data with no intrinsic blurring showed resolution of 1.0mm~1.5mm FWHM. However as we expected, reconstructed images from the experimental set-up with limitations failed to separate two Na-22 point sources 1.5mm apart. Experimental resolutions of 4mm FWHM in the longitudinal direction and 2mm FWHM in the transverse direction were obtained for the two point sources. Advisors/Committee Members: Clinthorne, Neal H. (committee member), Rogers, W. Leslie (committee member), Fessler, Jeffrey A. (committee member), He, Zhong (committee member).

Subjects/Keywords: Realtime Intraopeative PET Imaging; Online Parallel Image Reconstruction; Modified One Pass MLEM; Surgical PET Imaging Probe System; Image Guided Surgery; Biomedical Engineering; Engineering

…91 3 .6 REAL-TIME LIST MODE PET IMAGING RECONSTRUCTION USING REGULARIZED PSEUDO-INVERSE… …140 CHAPTER 5 PROTOTYPE OF THE PET IMAGING PROBE SYSTEM ........... 141 5 .1 A PIXILATED… …246 6. 2 .1 Interpretation of the PET Imaging Probe System: Adaptive Imaging System… …248 6. 2 .6 A Second-Generation Prototype of the PET Imaging Probe System ......... 248… …29 FIGURE 2-4. ILLUSTRATION OF THE INTRA-OPERATIVE PET IMAGING PROBE SYSTEM. ...... 31…

10 more images…

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APA (6^th Edition):

Huh, S. S. (2011). Preliminary Study of an Intra-operative PET Imaging Probe System. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/86331

Chicago Manual of Style (16^th Edition):

Huh, Sam Seoung. “Preliminary Study of an Intra-operative PET Imaging Probe System.” 2011. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021. http://hdl.handle.net/2027.42/86331.

MLA Handbook (7^th Edition):

Huh, Sam Seoung. “Preliminary Study of an Intra-operative PET Imaging Probe System.” 2011. Web. 15 Jan 2021.

Vancouver:

Huh SS. Preliminary Study of an Intra-operative PET Imaging Probe System. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2027.42/86331.

Council of Science Editors:

Huh SS. Preliminary Study of an Intra-operative PET Imaging Probe System. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/86331

Rochester Institute of Technology

2. Riddle, R. Scott. Retopologizing MRI and Diffusion Tensor Tractography Datasets for Real-time Interactivity.

Degree: MFA, Medical Illustration (CHST), 2016, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/9378

► Current technology allows MRI and other patient data to be translated into voxel-based 3D models for the purpose of visualization. However, these voxel models… (more)

▼ Current technology allows MRI and other patient data to be translated into voxel-based 3D models for the purpose of visualization. However, these voxel models are extremely complex and are not suitable for rapid real-time manipulation. For true “on-the-fly” interactivity, polygon-based models must be hand-built using other methods and imported into a game engine.This project develops an algorithm to translate complex datasets into optimized models for real-time interactivity without sacrificing accuracy of the original imaging modality. A working prototype, ready for integration into game engines, has been built with brain tumor data exported from OSIRIX1 and 3D Slicer2 via Mudbox3, retopologized in 3D Coat4 and re-imported to Maya5. White matter tracts detected by Diffusion Tensor Tractography are exported as volume models using 3D Slicer.The model has been integrated into the Unreal Development Kit (UDK)6 game engine to facilitate real-time interactivity across multiple platforms, including Mac, PC, Apple iOS, Google Android, Xbox 360, and SONY PlayStation. New techniques are being explored to automate and accelerate the process of retopologizing models. 1.Osirix – Advanced Open-Source PACS Workstation DICOM Viewer http://www.osirix-viewer.com/ 2. 3D Slicer- A multi-platform, free and open source software package for visualization and medical image computing http://www.3dslicer.org 3.MudBox – Autodesk¨ Mudbox™ 3D digital sculpting and digital painting software http://usa.autodesk. com 4.3D Coat – Retopologizing and 3D sculpting software http://3d-coat.com 5.MAYA - Autodesk¨Maya¨ 3D animation software delivers an end-to-end creative workflow with compression tools for animation, modeling, simulation, visual effects, rendering, matchmoving, and compositing on a highly extensible production platform http://usa.autodesk.com 6.Unreal Engine 3 – a complete development framework for PCs, iOS, Xbox 360¨, and PlayStation¨ 3, providing a vast array of core technologies, content creation tools and support infrastructure http://www. unrealengine.com/ Advisors/Committee Members: James Perkins.

Subjects/Keywords: Biomedical; Brain; Imaging; Medical; Neurosurgery; Realtime

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APA (6^th Edition):

Riddle, R. S. (2016). Retopologizing MRI and Diffusion Tensor Tractography Datasets for Real-time Interactivity. (Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/9378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Riddle, R Scott. “Retopologizing MRI and Diffusion Tensor Tractography Datasets for Real-time Interactivity.” 2016. Thesis, Rochester Institute of Technology. Accessed January 15, 2021. https://scholarworks.rit.edu/theses/9378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Riddle, R Scott. “Retopologizing MRI and Diffusion Tensor Tractography Datasets for Real-time Interactivity.” 2016. Web. 15 Jan 2021.

Vancouver:

Riddle RS. Retopologizing MRI and Diffusion Tensor Tractography Datasets for Real-time Interactivity. [Internet] [Thesis]. Rochester Institute of Technology; 2016. [cited 2021 Jan 15]. Available from: https://scholarworks.rit.edu/theses/9378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Riddle RS. Retopologizing MRI and Diffusion Tensor Tractography Datasets for Real-time Interactivity. [Thesis]. Rochester Institute of Technology; 2016. Available from: https://scholarworks.rit.edu/theses/9378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wayne State University

3. Mchugh, Christopher. Imaging Anti-Proliferative Compounds With Flt-Pet.

Degree: PhD, Cancer Biology, 2016, Wayne State University

URL: https://digitalcommons.wayne.edu/oa_dissertations/1561

► Imaging is critical in the detection and management of malignancies, and positron emission tomography (PET) is an imaging approach that provides information regarding cancer… (more)

▼ Imaging is critical in the detection and management of malignancies, and positron emission tomography (PET) is an imaging approach that provides information regarding cancer physiology through the tracking of molecular pathways and receptors. 3’-fluoro-3’-deoxythymidine (FLT) is a PET tracer designed to image cellular proliferation, which is a hallmark of cancer. FLT has been used to study the response of cancer to a variety of treatments such as chemotherapy, targeted agents, and radiation. Here we explored FLT retention as a biomarker to monitor the anti-proliferative effect of the synthetic glucocorticoid (GC) dexamethasone (Dex) on non-small cell lung cancer (NSCLC). The basis for this work was the recent finding that Dex can cause reversible cell cycle arrest in a subset of NSCLC cells leading to chemotherapy resistance. A similar phenomenon has been shown in several other solid tumor models treated with GCs. Through studies of cell line models, human xenografts, and NSCLC patients, we observed that although the susceptibility to Dex-mediated cell cycle arrest is variable between cancers, it could be detected using FLT-PET. We also examined the FLT ‘flare’ phenomenon, in which FLT uptake is transiently increased following treatment with drugs that reduce cellular thymidine synthesis. Two routinely used chemotherapeutic agents, pemetrexed and capecitabine, were found to produce marked increases in FLT accumulation, though the effect was variable in patients treated with capecitabine. The success of FLT led to the introduction of other thymidine analog PET tracers including 1-(2’-deoxy-2’-fluoro-β-D-arabinofuranosyl) thymidine (FMAU) and 1-(2’-deoxy-2’-fluoro-β-D-arabinofuranosyl) uracil (FAU). Uptake of FMAU has been shown to be related to mitochondrial mass and cellular stress, while FAU is a prodrug that requires activation by thymidylate synthase. Although capecitabine treatment produced a change from baseline in patients imaged with FLT, tracer retention was unchanged in patients imaged with FMAU and FAU, highlighting the differences in imaging properties between the tracers. In summary, FLT continues to show promise as a tool for the non-invasive monitoring of cellular proliferation, and may be a useful biomarker for the prediction of GC sensitivity in solid tumors. Advisors/Committee Members: Anthony F. Shields.

Subjects/Keywords: Cancer; FLT; Imaging; PET; Biology

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APA (6^th Edition):

Mchugh, C. (2016). Imaging Anti-Proliferative Compounds With Flt-Pet. (Doctoral Dissertation). Wayne State University. Retrieved from https://digitalcommons.wayne.edu/oa_dissertations/1561

Chicago Manual of Style (16^th Edition):

Mchugh, Christopher. “Imaging Anti-Proliferative Compounds With Flt-Pet.” 2016. Doctoral Dissertation, Wayne State University. Accessed January 15, 2021. https://digitalcommons.wayne.edu/oa_dissertations/1561.

MLA Handbook (7^th Edition):

Mchugh, Christopher. “Imaging Anti-Proliferative Compounds With Flt-Pet.” 2016. Web. 15 Jan 2021.

Vancouver:

Mchugh C. Imaging Anti-Proliferative Compounds With Flt-Pet. [Internet] [Doctoral dissertation]. Wayne State University; 2016. [cited 2021 Jan 15]. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1561.

Council of Science Editors:

Mchugh C. Imaging Anti-Proliferative Compounds With Flt-Pet. [Doctoral Dissertation]. Wayne State University; 2016. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1561

University of Manitoba

4. Shams, Ehsan. A slow control system with gain stabilization for a small animal MR-compatible PET insert.

Degree: Biomedical Engineering, 2014, University of Manitoba

URL: http://hdl.handle.net/1993/30140

► The Biomedical Imaging Lab at the University of Manitoba is building an MR compatible PET insert system. The detectors include SensL SPM ArraySB-4 SiPMs and… (more)

Subjects/Keywords: PET; medical imaging; nuclear medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shams, E. (2014). A slow control system with gain stabilization for a small animal MR-compatible PET insert. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/30140

Chicago Manual of Style (16^th Edition):

Shams, Ehsan. “A slow control system with gain stabilization for a small animal MR-compatible PET insert.” 2014. Masters Thesis, University of Manitoba. Accessed January 15, 2021. http://hdl.handle.net/1993/30140.

MLA Handbook (7^th Edition):

Shams, Ehsan. “A slow control system with gain stabilization for a small animal MR-compatible PET insert.” 2014. Web. 15 Jan 2021.

Vancouver:

Shams E. A slow control system with gain stabilization for a small animal MR-compatible PET insert. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1993/30140.

Council of Science Editors:

Shams E. A slow control system with gain stabilization for a small animal MR-compatible PET insert. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/30140

University of Minnesota

5. Glumac, Paige M. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.

Degree: PhD, Pharmacology, 2019, University of Minnesota

URL: http://hdl.handle.net/11299/206273

► An increasing number of men are developing a lethal, non-androgen receptor (AR) driven form of prostate cancer (PCa) known as aggressive variant prostate cancer (AVPC).… (more)

Subjects/Keywords: CD133; PET imaging; Prostate Cancer

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APA (6^th Edition):

Glumac, P. M. (2019). Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/206273

Chicago Manual of Style (16^th Edition):

Glumac, Paige M. “Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.” 2019. Doctoral Dissertation, University of Minnesota. Accessed January 15, 2021. http://hdl.handle.net/11299/206273.

MLA Handbook (7^th Edition):

Glumac, Paige M. “Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.” 2019. Web. 15 Jan 2021.

Vancouver:

Glumac PM. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/11299/206273.

Council of Science Editors:

Glumac PM. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/206273

Boston University

6. Nguyen, Hoan. Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative.

Degree: MS, Bioimaging, 2014, Boston University

URL: http://hdl.handle.net/2144/14667

► Progression of Alzheimer's disease has been associated with the deposition of aggregated amyloid beta (Aβ) protein in the brain. Though first described in post-mortal tissue,… (more)

Subjects/Keywords: Medical imaging; Alzheimer; PET; Symmetry

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APA (6^th Edition):

Nguyen, H. (2014). Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14667

Chicago Manual of Style (16^th Edition):

Nguyen, Hoan. “Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative.” 2014. Masters Thesis, Boston University. Accessed January 15, 2021. http://hdl.handle.net/2144/14667.

MLA Handbook (7^th Edition):

Nguyen, Hoan. “Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative.” 2014. Web. 15 Jan 2021.

Vancouver:

Nguyen H. Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2144/14667.

Council of Science Editors:

Nguyen H. Characterizing the symmetry of amyloid beta protein retention in Alzheimer's disease using florbetapir positron emission tomography - a study using data from the Alzheimer's disease neuroimaging initiative. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14667

University of Manchester

7. Armstrong, Ian. Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography.

Degree: 2017, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784

► Positron Emission Tomography (PET) plays an essential role in the management of patients with cancer. It is used to detect and characterise malignancy as well… (more)

▼ Positron Emission Tomography (PET) plays an essential role in the management of patients with cancer. It is used to detect and characterise malignancy as well as monitor response to therapy. PET is a quantitative imaging tool, producing images that quantify the uptake of a radiotracer that has been administered to the patient. The most common measure of uptake derived from the image is known as a Standardised Uptake Value (SUV). Data acquired on the scanner is processed to produce images that are reported by clinicians. This task is known as image reconstruction and uses computational algorithms to process the scan data. The last decade has seen substantial development of these algorithms, which have become commercially available: modelling of the scanner spatial resolution (resolution modelling) and time of flight (TOF). The Biograph mCT was the first scanner from Siemens Healthcare to feature these two algorithms and the scanner at Central Manchester University Hospitals was the first Biograph mCT to go live in the UK. This PhD project, sponsored by Siemens Healthcare, aims to evaluate the effect of these algorithms on SUV in routine oncology imaging through a combination of phantom and patient studies.Resolution modelling improved visualisation of small objects and resulted in significant increases of uptake measurements. This may pose a challenge to clinicians when interpreting established uptake metrics that are used as an indication of disease status. Resolution modelling reduced the variability of SUV. This improved precision is particularly beneficial when assessing SUV changes during therapy monitoring.TOF was shown to reduce image noise with a conservation of FDG uptake measurements, relative to non-TOF algorithms. As a result of this work, TOF has been used routinely since mid-2014 at the CMUH department. This has facilitated a reduction of patient and staff radiation dose and an increase of 100 scans performed each year in the department. Advisors/Committee Members: WILLIAMS, HEATHER HA, Williams, Heather, Matthews, Julian.

Subjects/Keywords: Oncology; Medical Imaging; Image Reconstruction; PET imaging

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APA (6^th Edition):

Armstrong, I. (2017). Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784

Chicago Manual of Style (16^th Edition):

Armstrong, Ian. “Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography.” 2017. Doctoral Dissertation, University of Manchester. Accessed January 15, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784.

MLA Handbook (7^th Edition):

Armstrong, Ian. “Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography.” 2017. Web. 15 Jan 2021.

Vancouver:

Armstrong I. Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Jan 15]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784.

Council of Science Editors:

Armstrong I. Quantitative Accuracy of Iterative Reconstruction Algorithms in Positron Emission Tomography. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306784

Harvard University

8. Lacy, Jessica. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.

Degree: Doctor of Medicine, 2014, Harvard University

URL: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616

► Poly(ADP-ribose)polymerase-1 and -2 (PARP1/2) are nuclear proteins involved in DNA repair. Tumors with defects in homologous recombination, including BRCA1- and BRCA2-deficient cancers, have been shown… (more)

Subjects/Keywords: PARP; BRCA; PET imaging; PET/CT imaging; fluorescence microscopy

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APA (6^th Edition):

Lacy, J. (2014). Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. (Doctoral Dissertation). Harvard University. Retrieved from http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616

Chicago Manual of Style (16^th Edition):

Lacy, Jessica. “Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.” 2014. Doctoral Dissertation, Harvard University. Accessed January 15, 2021. http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616.

MLA Handbook (7^th Edition):

Lacy, Jessica. “Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.” 2014. Web. 15 Jan 2021.

Vancouver:

Lacy J. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. [Internet] [Doctoral dissertation]. Harvard University; 2014. [cited 2021 Jan 15]. Available from: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616.

Council of Science Editors:

Lacy J. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. [Doctoral Dissertation]. Harvard University; 2014. Available from: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616

Boston University

9. Wilson, Colin Michael. Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies.

Degree: MA, Radiology, 2011, Boston University

URL: http://hdl.handle.net/2144/33592

► The standardized uptake value (SUV) is increasingly being used for diagnosis, staging, and monitoring disease in clinical oncology. Comparing tumor SUV to background SUV is… (more)

Subjects/Keywords: Clinical oncology; PET scans; FDG PET/CT imaging

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APA (6^th Edition):

Wilson, C. M. (2011). Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/33592

Chicago Manual of Style (16^th Edition):

Wilson, Colin Michael. “Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies.” 2011. Masters Thesis, Boston University. Accessed January 15, 2021. http://hdl.handle.net/2144/33592.

MLA Handbook (7^th Edition):

Wilson, Colin Michael. “Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies.” 2011. Web. 15 Jan 2021.

Vancouver:

Wilson CM. Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies. [Internet] [Masters thesis]. Boston University; 2011. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2144/33592.

Council of Science Editors:

Wilson CM. Value of using liver FDG uptake as background activity in standardizing FDG PET/CT studies. [Masters Thesis]. Boston University; 2011. Available from: http://hdl.handle.net/2144/33592

University of Adelaide

10. Dmochowska, Nicole. Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease.

Degree: 2019, University of Adelaide

URL: http://hdl.handle.net/2440/125041

► Inflammatory bowel disease (IBD) is a chronic, relapsing and remitting inflammatory condition of the gastrointestinal tract. The diagnosis and monitoring of IBD is reliant on… (more)

▼ Inflammatory bowel disease (IBD) is a chronic, relapsing and remitting inflammatory condition of the gastrointestinal tract. The diagnosis and monitoring of IBD is reliant on endoscopic techniques which are invasive and do not provide quantification. Molecular imaging approaches such as immuno-PET have superior sensitivity and provide quantitative information of the entire body. Immuno-PET combines the superior target selectivity provided by antibodies with the sensitivity of PET. This thesis outlines the development of two novel radiolabelled antibody tracers against intestinal inflammation in a preclinical model of IBD and one novel tracer against intestinal fibrosis in a model of chronic murine IBD. Symptom flare in IBD typically corresponds with an increased activation of innate immune pathways. We aimed to compare immuno-PET of the innate immune mediators IL-1β and CD11b against standard 18F-FDG and MRI to detect colonic inflammation. For visualising intestinal inflammation, 89Zr-α-IL-1β and 89Zr-α-CD11b immuno-PET detected colonic inflammation, as did 18F-FDG, and all PET tracers were more sensitive than MRI. While 18F-FDG volumes of interest correlated with colitis severity and a strong trend was observed with 89Zr-α-IL-1β, no correlation was observed for 89Zr-α-CD11b or MRI. 89Zr-α-IL-1β was distributed mainly to the gastrointestinal tract, while 89Zr-α-CD11b was distributed in more tissue types. Intestinal fibrosis is one of the most common complications of IBD, with severe fibrosis leading to stricture and stenosis in approximately 30% of patients. Currently, intestinal fibrosis is diagnosed and monitored using endoscopies and MRI. Fibrosis is characterised by the excessive deposition of extracellular matrix (ECM) as a result of multiple periods of inflammation and subsequent healing, as seen in IBD and murine colitis. Matrix metalloproteinases (MMP) play a large role in fibrogenic pathways by regulating the deposition of ECM during tissue renewal. MMP-9 is found to be elevated in fibrotic tissue resected from IBD patients and in preclinical models of intestinal fibrosis. We aimed to visualise intestinal fibrosis by targeting pro-MMP-9 using f(ab’)2 antibody fragments, radiolabelled with zirconium-89. This was the first immuno-PET study of fibrosis in any tissue in a preclinical or clinical setting. In our preclinical model of chronic IBD, 89Zr-pro-MMP-9- f(ab’)2 successfully detected intestinal fibrosis in the absence of inflammation. Furthermore, immuno-PET and biodistribution studies indicated that the kidneys became fibrotic after multiple rounds of DSS. This was further confirmed by an increase in collagen and pro-MMP- 9 levels in the kidneys, in the absence of elevated immune markers. As the mechanisms underlying fibrosis are similar across all organs, immuno-PET of pro-MMP-9 may be a valuable addition to the detection of fibrosis in all tissues. Additionally, development of these technologies for human subjects will provide a less invasive approach than endoscopy for diagnosing and monitoring IBD. Advisors/Committee Members: Hughes, Patrick (advisor), Tieu, William (advisor), Smid, Scott (advisor), Takhar, Prab (advisor), School of Medicine (school).

Subjects/Keywords: Molecular imaging; immuno-PET; PET; gastrointestinal; colitis; fibrosis

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APA (6^th Edition):

Dmochowska, N. (2019). Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/125041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dmochowska, Nicole. “Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease.” 2019. Thesis, University of Adelaide. Accessed January 15, 2021. http://hdl.handle.net/2440/125041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dmochowska, Nicole. “Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease.” 2019. Web. 15 Jan 2021.

Vancouver:

Dmochowska N. Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease. [Internet] [Thesis]. University of Adelaide; 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2440/125041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dmochowska N. Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease. [Thesis]. University of Adelaide; 2019. Available from: http://hdl.handle.net/2440/125041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

11. McKinley, Eliot Thomas. FLT PET in colorectal cancer.

Degree: PhD, Biomedical Engineering, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/11047

► Biomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. With an increasing reliance on molecularly targeted therapies, there… (more)

▼ Biomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. With an increasing reliance on molecularly targeted therapies, there remains an equally critical challenge to develop and validate specific biomarkers that reflect target inhibition, pathway inactivation, and predict overall clinical response. Most biomarkers utilized in oncology studies require tissue sampling which is highly susceptible to sampling error due and bias from heterogeneity. These limitations highlight a critical need to accelerate the translation of novel imaging approaches that are capable of reporting cellular and molecular responses of tumor cells to therapy. Presently, a major impediment to the clinical translation of novel imaging methodology is a lack of understanding of how targeted therapy can affect uptake of molecular probes and a lack appropriate validation studies conducted within relevant biological contexts. This dissertation seeks to elucidate molecular determinants that affect 3’-deoxy-3’[18F]-fluorothymidine ([18F]-FLT) PET imaging as a biomarker of response to targeted therapeutics in colorectal cancer (CRC) in both pre-clinical models and in patients. Using pre-clinical mouse models, [18F]-FLT PET was shown to measure TK1 protein levels in a tumor, was blind to utilization of the de novo pathway of thymidine synthesis, and may not correlate with Ki67 IHC measures of total cellular proliferation in a prognostic setting. Also is preclinical mouse models of CRC, [18F]-FLT was shown to serve as an early PET biomarker that may be sensitive to activation of pro-survival mechanisms that may predict tumors that are more likely to resist treatment and ultimately may be more prone to recurrence. In the clinical setting, [18F]-FLT PET was shown to correlate with treatment response in KRAS mutant rectal cancers after EGFR targeted therapy and chemoradiotherapy. Each of these components advance the understanding the strengths and weaknesses of [18F]-FLT and how [18F]-FLT PET can best be utilized in clinical practice Advisors/Committee Members: Robert J. Coffey (committee member), John C. Gore (committee member), Melissa C. Skala (committee member), M. Kay Washington (committee member), H. Charles Manning (Committee Chair).

Subjects/Keywords: FLT; PET; colorectal cancer; imaging; oncology

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APA (6^th Edition):

McKinley, E. T. (2013). FLT PET in colorectal cancer. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11047

Chicago Manual of Style (16^th Edition):

McKinley, Eliot Thomas. “FLT PET in colorectal cancer.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed January 15, 2021. http://hdl.handle.net/1803/11047.

MLA Handbook (7^th Edition):

McKinley, Eliot Thomas. “FLT PET in colorectal cancer.” 2013. Web. 15 Jan 2021.

Vancouver:

McKinley ET. FLT PET in colorectal cancer. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1803/11047.

Council of Science Editors:

McKinley ET. FLT PET in colorectal cancer. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/11047

University of Toronto

12. MacDonald, Thomas. Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles.

Degree: 2013, University of Toronto

URL: http://hdl.handle.net/1807/43251

►

Porphyrins are naturally occurring molecules. Porphysomes are simple multimodal nanoparticles that derive their multifunctionality from porphyrin-based building-blocks. While previous studies have probed their interactions with… (more)

Subjects/Keywords: Nanomedicine; Imaging; Cancer; PET; MRI; Porphyrins; 491

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APA (6^th Edition):

MacDonald, T. (2013). Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/43251

Chicago Manual of Style (16^th Edition):

MacDonald, Thomas. “Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles.” 2013. Masters Thesis, University of Toronto. Accessed January 15, 2021. http://hdl.handle.net/1807/43251.

MLA Handbook (7^th Edition):

MacDonald, Thomas. “Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles.” 2013. Web. 15 Jan 2021.

Vancouver:

MacDonald T. Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1807/43251.

Council of Science Editors:

MacDonald T. Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/43251

Rice University

13. Valiollahzadeh, Majid. Compressive Sensing in Positron Emission Tomography (PET) Imaging.

Degree: PhD, Engineering, 2015, Rice University

URL: http://hdl.handle.net/1911/88183

► Positron emission tomography (PET) is a nuclear medicine functional imaging modality, applicable to several clinical problems, but especially in detecting the metabolic activity (as in… (more)

▼ Positron emission tomography (PET) is a nuclear medicine functional imaging modality, applicable to several clinical problems, but especially in detecting the metabolic activity (as in cancer). PET scanners use multiple rings of gamma ray detectors that surround the patient. These scanners are quite expensive (1-3 million dollars), therefore a technology that would allow the reduction in the number of detectors per ring without affecting image quality, could reduce the scanner cost, thereby making this imaging modality more accessible to patients. In this thesis , a mathematical technique known as compressive sensing is applied in an effort to decrease the number of detectors required, while maintaining good image quality. A CS model was developed based on a combination of gradient magnitude and wavelet domains to recover missing observations associated with PET data acquisition. The CS model also included a Poisson-distributed noise term. The overall model was formulated as an optimization problem wherein the cost function was a weighted sum of the total variation and the L1-norm of the wavelet coefficients. Subsequently, the cost function was minimized subject to the CS model equations, the partially observed data, and a penalty function for noise suppression (the Poisson log-likelihood function). We refer to the complete model as the WTV model. This thesis also explores an alternative reconstruction method, wherein a different CS model based on an adaptive dictionary learning (DL) technique for data recovery in PET imaging was developed. Specifically, a PET image is decomposed into small overlapped patches and the dictionary is learned from these overlapped patches. The technique has good sparsifying properties and the dictionary tends to capture local as well as structural similarities, without sacrificing resolution. Recovery is accomplished in two stages: a dictionary learning phase followed by a reconstruction step. In addition to developing optimized CS reconstruction, this thesis also investigated: (a) the limits of detector removal when using the DL CS reconstruction algorithm; and (b) the optimal detector removal configuration per ring while minimizing the impact on image quality following recovery using the CS model. Results of these investigations can serve to help make PET scanners more affordable while maintaining image quality. These results can also be used to improve patient throughput by redesigning scanners so that removed detectors can be placed in axial extent to image a larger portion of the body. This will help increase scanner throughput hence improve scanner efficiency as well as patient discomfort due to long scan time. Advisors/Committee Members: Clark, John (advisor), Veeraghavan, Ashok (committee member), Jacot, Jeffrey (committee member), Mawlawi, Osama (committee member), kelly, Kevin (committee member).

Subjects/Keywords: Compressive sensing; PET imaging; signal processing

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APA (6^th Edition):

Valiollahzadeh, M. (2015). Compressive Sensing in Positron Emission Tomography (PET) Imaging. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/88183

Chicago Manual of Style (16^th Edition):

Valiollahzadeh, Majid. “Compressive Sensing in Positron Emission Tomography (PET) Imaging.” 2015. Doctoral Dissertation, Rice University. Accessed January 15, 2021. http://hdl.handle.net/1911/88183.

MLA Handbook (7^th Edition):

Valiollahzadeh, Majid. “Compressive Sensing in Positron Emission Tomography (PET) Imaging.” 2015. Web. 15 Jan 2021.

Vancouver:

Valiollahzadeh M. Compressive Sensing in Positron Emission Tomography (PET) Imaging. [Internet] [Doctoral dissertation]. Rice University; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1911/88183.

Council of Science Editors:

Valiollahzadeh M. Compressive Sensing in Positron Emission Tomography (PET) Imaging. [Doctoral Dissertation]. Rice University; 2015. Available from: http://hdl.handle.net/1911/88183

University of Melbourne

14. HASKALI, MOHAMMAD. Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer.

Degree: 2014, University of Melbourne

URL: http://hdl.handle.net/11343/52367

► Positron Emission Tomography (PET) is a molecular imaging technique, requiring biologically active molecules that are radiolabelled with positron emitting radionuclides. [18F]Fluorine is considered an ideal… (more)

▼ Positron Emission Tomography (PET) is a molecular imaging technique, requiring biologically active molecules that are radiolabelled with positron emitting radionuclides. [18F]Fluorine is considered an ideal radionuclide utilised for PET imaging. When high affinity peptides are labelled with [18F]fluorine, they form an excellent targeting molecule that can be utilised to characterise tumours using PET imaging. This project investigated an improved radiosynthesis route for the production of 4-nitrophenyl 2-[18F]fluoropropionate ([18F]NFP), a peptide [18F]fluorination synthon. [18F]NFP was produced in a single radiochemical step and the synthesis was fully automated on both TRACERLab FXFN and iPHASE FlexLab radiosynthesis modules. The automated radiosynthesis of [18F]NFP was accomplished in 45 min and in 29% decay corrected yield. The improved synthesis route of [18F]NFP, allowed the synthesis of the gold standard tracer for αvβ3 PET imaging [18F]FP-GalactoRGD in 7% n.d.c. yield and in less than half of the reported synthesis time.1 Furthermore, [18F]FPPRGD2 was prepared in 4% n.d.c. yield from free fluoride within 94–105 min . [18F]FP-GalactoRGD and [18F]FPPRGD2 were compared in-vivo under similar conditions. [18F]FPPRGD2 exhibited improved biological character in our model for αvβ3 expression. Moreover, novel RGD peptides were synthesised for the targeting of metastatic tumours. The biological properties of the novel RGD ligands were modified by site specific sulfonation of tyrosine. Sulfonation of tyrosine was accomplished utilising readily available chlorosulfonic acid and trifluoroacetic acid. The corresponding sulfonated peptides were generated in good chemical yields (60%). Sulfonated peptides were subsequently labelled with [18F]NFP and their biological properties were investigated. This methodology was employed to prepare [18F]FP-c(RGDy(SO3)K) and [18F]FP-E-c(RGDy(SO3)K)2. [18F]FP-c(RGDy(SO3)K) exhibited comprable biological properties to [18F]FP-GalactoRGD. However, [18F]FP-E-c(RGDy(SO3)K)2 demonstrated improved biological properties over all other peptides examined for the imaging of αvβ3 Integrins in our models. The project also exploited the radiolabelling of biomolecules targetting apoptotic cells. Annexin V was labelled by [18F]SFB, to generate the [18F]FB-Annexin V, an imaging agent for in-vivo apoptosis measurement. Furthermore, duramycin (an apoptosis targeting peptide) was initially labelled with [18F]SFB to generate [18F]FB-duramycin in 16% n.d.c. yield from [18F]SFB within 150–175 min. [18F]FB-duramycin exhibited high liver accumulation presumably as a result of its hydrophobic nature. The hydrophilicity of duramycin was modified by mono-glycosylation and latter labelling with [18F]NFP to form [18F]FP-galacto-duramycin in 45% n.d.c. from [18F]NFP within 90–100 min. [18F]FP-galacto-duramycin presented improved biological properties over [18F]FB-duramycin as demonstrated by small animal imaging. The biological properties of duramycin were further enhanced by di-glycosylation. The…

Subjects/Keywords: radiochemistry; PET imaging; radiolabelling; 18-fluorine; peptides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

HASKALI, M. (2014). Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/52367

Chicago Manual of Style (16^th Edition):

HASKALI, MOHAMMAD. “Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer.” 2014. Doctoral Dissertation, University of Melbourne. Accessed January 15, 2021. http://hdl.handle.net/11343/52367.

MLA Handbook (7^th Edition):

HASKALI, MOHAMMAD. “Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer.” 2014. Web. 15 Jan 2021.

Vancouver:

HASKALI M. Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer. [Internet] [Doctoral dissertation]. University of Melbourne; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/11343/52367.

Council of Science Editors:

HASKALI M. Synthesis and [18F] fluorine-radiolabelling of peptides for positron emission tomography imaging of cancer. [Doctoral Dissertation]. University of Melbourne; 2014. Available from: http://hdl.handle.net/11343/52367

Washington University in St. Louis

15. Peng, Xin. Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET.

Degree: PhD, Chemistry, 2013, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/art_sci_etds/162

► Amide linkages are favored in medicinal chemistry to build molecule libraries because of their vast presence in biomolecules, such as peptides and proteins. In… (more)

▼ Amide linkages are favored in medicinal chemistry to build molecule libraries because of their vast presence in biomolecules, such as peptides and proteins. In addition, molecules with amide linkages have more flexible conformation, thus these molecules are more likely to orient to a conformation that fits a protein's binding pocket. Our group has been engaging in developing selective dopamine D3 receptor ligands and sigma-2 receptor ligands. In the past few years, amide linkages were employed in the majority of the dopamine D3 and sigma-2 ligands we have developed. Many of the benzamide ligands showed promising in vitro data, but few exhibit great in vivo characteristics. One of the reasons is that amide linkage was identified as a potential metabolic site for in vivo modification by proteases. My research explored new synthons as replacements for the amide linkages in dopamine D3 receptor ligands and sigma-2 receptor ligands. 5-Membered heterocycle rings, such as triazoles and isoxazoles, have been reported to exhibit resistance to metabolic degradation and represent novel isosteric substitution of an amide linkage. In addition, the hetero atoms may participate in hydrogen bonding and dipole-dipole interactions, which could result in more favorable receptor binding properties. The second step of the research reported in this thesis is the development of selective dopamine D3 receptor tracers and sigma-2 receptor tracers for non-invasive Positron Emission Tomography (PET). Dopamine D3 receptors play an important role in Central Nervous System (CNS) and may be associated with several CNS diseases and behavioral disorders, including psychostimulant abuse. Sigma-2 receptors have been shown to be expressed in a variety of human tumors, in particular, those of breast, melanoma, non-small-cell lung carcinoma, brain, prostate and tumors of neural origin. Sigma-2 receptors are the only validated biomarker for imaging the proliferative status of tumor cells. In this thesis, two dopamine D3 ligands were radiolabeled and evaluated in non-human primate microPET studies. Two sigma-2 ligands were also radiolabeled and evaluated in rodents bearing tumor cells. We have identified the two sigma-2 tracers [11C]PX-II-116]and [18F]PX-II-120]as promising PET tracers for imaging proliferative status of tumor cells. Advisors/Committee Members: Robert H Mach, Joshua Maurer, Joseph Ackerman, Peter Gaspar, Suzanne Lapi, John-Stephen Taylor.

Subjects/Keywords: cancer; CNS; Imaging; PET; Radiotracers; Chemistry

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APA (6^th Edition):

Peng, X. (2013). Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/art_sci_etds/162

Chicago Manual of Style (16^th Edition):

Peng, Xin. “Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET.” 2013. Doctoral Dissertation, Washington University in St. Louis. Accessed January 15, 2021. https://openscholarship.wustl.edu/art_sci_etds/162.

MLA Handbook (7^th Edition):

Peng, Xin. “Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET.” 2013. Web. 15 Jan 2021.

Vancouver:

Peng X. Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2013. [cited 2021 Jan 15]. Available from: https://openscholarship.wustl.edu/art_sci_etds/162.

Council of Science Editors:

Peng X. Heterocycle-Amide Isosteres: Application in the Development of Receptor-Based Imaging Agents for PET. [Doctoral Dissertation]. Washington University in St. Louis; 2013. Available from: https://openscholarship.wustl.edu/art_sci_etds/162

University of Edinburgh

16. Joshi, Nikhil Vilas. Novel molecular imaging of cardiovascular disease in man.

Degree: PhD, 2016, University of Edinburgh

URL: http://hdl.handle.net/1842/25394

► Cardiovascular disease remains the commonest cause of death worldwide. The majority of deaths are caused by atherosclerotic plaque rupture with resultant myocardial infarction or stroke,… (more)

▼ Cardiovascular disease remains the commonest cause of death worldwide. The majority of deaths are caused by atherosclerotic plaque rupture with resultant myocardial infarction or stroke, or rupture of abdominal aortic aneurysms. Conventional imaging modalities have consistently failed to identify atherosclerotic plaques or aneurysms with high-risk pathological features that are at highest risk of rupture or progression. The development of modern molecular imaging techniques targeted at these features could lead to the identification of such high-risk plaques and aneurysms in vivo and guide the development of novel treatment strategies. The aim of this thesis was to evaluate whether novel molecular modalities have a role in providing new insights into biological disease processes, and identify high-risk plaques and aneurysms. Using positron emission tomography-computed tomography (PET-CT), 18F-fluorodeoxyglucose and 18F-fluoride were utilised as markers of metabolic inflammation and active calcification. Cellular inflammation was assessed using ultrasmall superparamagnetic particles of iron oxide (USPIO) enhanced magnetic resonance imaging (MRI). In a prospective trial, 80 patients with myocardial infarction (n=40) and stable angina (n=40) underwent 18F-fluoride and 18F-fluorodeoxyglucose PET-CT, and invasive coronary angiography (Chapter 3). Intense 18F-fluoride uptake localised to recently ruptured plaque in patients with acute myocardial infarction. In patients with stable coronary artery disease, 18F-fluoride uptake identified coronary plaques with high-risk features on intravascular ultrasound. 18F-fluoride PET-CT is the first noninvasive imaging method to identify and localise ruptured and high-risk coronary plaques. Aortic vascular uptake of 18F- fluorodeoxyglucose was studied in patients with myocardial infarction and stable angina (Chapter 4). In a separate outcome of 1,003 patients enrolled in the Global Registry of Acute Coronary Events, we further evaluated whether infarct size predicted recurrent coronary events. Patients with myocardial infarction had higher remote atherosclerotic tracer uptake that correlated with the degree of myocardial necrosis, and exceeded that observed in patients with stable coronary disease. The outcome cohort demonstrated that patients with higher degree of myocardial necrosis had the highest risk of early recurrent myocardial infarction. This supports the hypothesis that acute myocardial infarction exacerbates systemic atherosclerotic inflammation and remote plaque destabilization: myocardial infarction begets myocardial infarction. In a prospective imaging cohort, the role inflammation and calcification was assessed in 63 patients with abdominal aortic aneurysms and 19 age and sex matched patients with atherosclerosis (Chapter 5). Compared to non-aneurysmal segments, enhanced inflammation and calcification was observed within the wall of aortic aneurysmal segments. In comparison to matched controls with atherosclerosis, the entire aorta in those with aortic aneurysm appears…

Subjects/Keywords: 616.1; atherosclerosis; aneurysm; molecular imaging; PET-CT

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APA (6^th Edition):

Joshi, N. V. (2016). Novel molecular imaging of cardiovascular disease in man. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/25394

Chicago Manual of Style (16^th Edition):

Joshi, Nikhil Vilas. “Novel molecular imaging of cardiovascular disease in man.” 2016. Doctoral Dissertation, University of Edinburgh. Accessed January 15, 2021. http://hdl.handle.net/1842/25394.

MLA Handbook (7^th Edition):

Joshi, Nikhil Vilas. “Novel molecular imaging of cardiovascular disease in man.” 2016. Web. 15 Jan 2021.

Vancouver:

Joshi NV. Novel molecular imaging of cardiovascular disease in man. [Internet] [Doctoral dissertation]. University of Edinburgh; 2016. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1842/25394.

Council of Science Editors:

Joshi NV. Novel molecular imaging of cardiovascular disease in man. [Doctoral Dissertation]. University of Edinburgh; 2016. Available from: http://hdl.handle.net/1842/25394

University of Georgia

17. Thom, Sarah Elisabeth. The speech-related neural activity of individual stutterers and groups of stutterers.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/25070

► Purpose: To (a) investigate neural activity of individuals who stutter, and (b) compare individual results with previously published data from groups of stutterers. Method: Three… (more)

Subjects/Keywords: Stuttering; PET; brain imaging; inter-subject averaging

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APA (6^th Edition):

Thom, S. E. (2014). The speech-related neural activity of individual stutterers and groups of stutterers. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thom, Sarah Elisabeth. “The speech-related neural activity of individual stutterers and groups of stutterers.” 2014. Thesis, University of Georgia. Accessed January 15, 2021. http://hdl.handle.net/10724/25070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thom, Sarah Elisabeth. “The speech-related neural activity of individual stutterers and groups of stutterers.” 2014. Web. 15 Jan 2021.

Vancouver:

Thom SE. The speech-related neural activity of individual stutterers and groups of stutterers. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10724/25070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thom SE. The speech-related neural activity of individual stutterers and groups of stutterers. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

18. Chowdhury, Mohammed. Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty.

Degree: PhD, 2020, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/306869

► Peripheral arterial disease (PAD) is a major cause of CVD-related death and disability. Restenosis is common, occurring in 40-60% of cases at 12 months following… (more)

▼ Peripheral arterial disease (PAD) is a major cause of CVD-related death and disability. Restenosis is common, occurring in 40-60% of cases at 12 months following lower extremity percutaneous transluminal angioplasty (PTA). No such method exists to identify patients who are at risk from restenosis before intervention. Tracers of inflammation (18F-FDG; fluorodeoxyglucose) and calcification (18F-NaF; sodium fluoride) are higher in restenosis following lower limb angioplasty in patients with peripheral arterial disease, and drug-coated balloons (DCB) dampen the inflammatory process, in an atherosclerotic rabbit model. In the prospective clinical study arm (CA), 50 patients with symptomatic PAD underwent 18F-NaF and 18F-FDG PET imaging of the superficial femoral artery (SFA), pre- and 6-weeks post-angioplasty. The primary outcome was restenosis at 12 months. DCB PTA was studied (compared to plain PTA) using near infrared fluorescence-optical coherence tomography hybrid imaging (NIRF-OCT) and plaque burden assessed by intravascular ultrasound (IVUS), in the experimental arm (EA). 40 patients were used for formal analysis. 14 patients (35%) reached the primary outcome of restenosis. Pre-PTA TBRmax in the restenosis group for 18F-FDG (2.43 [IQR 2.29 – 2.61] and 18F-NaF (2.61 [IQR 2.50 – 2.77]) were higher than the no-restenosis equivalent groups (1.63 [IQR 1.52 – 1.78] and 1.69 [IQR 1.54 – 1.77], p< 0.001). Furthermore, in the no-restenosis group there was a drop in both 18F-FDG and 18F-NaF tracer uptake (p=0.034 and 0.047, respectively) between the two timepoints; a finding not observed in the restenosis group. Experimentally, Plaque pathobiology assessment using NIRF after PTA vs. DCB treatment (42.91 nM vs 17.35 nM, p = 0.028) favoured DCB use to reduce inflammatory effects of angioplasty. Furthermore, DCB use demonstrated neointimal area regression (-2.55 % [IQR -5.35 to -0.43]) versus growth with PTA use (+6.29% [IQR 4.20 – 7.79]; p =0.002), as assessed by IVUS. Together our findings suggest that non-invasive and invasive structural-molecular imaging provide unique but complementary insights into the pathophysiology of restenosis, specifically inflammatory and calcific mediators of arterial remodelling following injury.

Subjects/Keywords: PAD; Molecular imaging; PET/CT; Restenosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chowdhury, M. (2020). Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/306869

Chicago Manual of Style (16^th Edition):

Chowdhury, Mohammed. “Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty.” 2020. Doctoral Dissertation, University of Cambridge. Accessed January 15, 2021. https://www.repository.cam.ac.uk/handle/1810/306869.

MLA Handbook (7^th Edition):

Chowdhury, Mohammed. “Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty.” 2020. Web. 15 Jan 2021.

Vancouver:

Chowdhury M. Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Jan 15]. Available from: https://www.repository.cam.ac.uk/handle/1810/306869.

Council of Science Editors:

Chowdhury M. Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://www.repository.cam.ac.uk/handle/1810/306869

University of Manchester

19. Carrascal Minino, Amaia. The use of spin traps and spin scavengers for imaging oxidative damage.

Degree: 2019, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:319465

► Spin traps and scavengers have been used to detect free radicals for decades. They react with free radical molecules forming adducts that either prolong the… (more)

▼ Spin traps and scavengers have been used to detect free radicals for decades. They react with free radical molecules forming adducts that either prolong the free radical signal (spin traps) or void it (spin scavengers). This reactivity has been exploited in electron spin resonance (ESR), a technique that despite its low sensitivity it is still considered the gold standard to detect free radicals. In this thesis the aim was to test if spin traps and spin scavengers could be adapted to other analytical modalities with more sensitivity and/or quantification capabilities. The infrastructures available allowed us to consider positron emission tomography (PET) and mass spectrometry (LC-MS and imaging). Firstly the molecules were evaluated in in vitro competition experiments using LC-MS. A simple method to evaluate oxidative damage products was developed, and commercially available spin traps and scavengers were tested. The experimental results agreed with the literature pointing towards DMPO (5,5-dimethyl-1-pyrroline- N oxide) like molecules as suitable tracers. In the second results chapters three F-18 PET tracers with spin trap or scavenger reactivity were produced and tested in cell uptake experiments. The experiments were negative for uptake. The third part of the thesis was planned for investigation of the mechanism of action of the successful PET tracer but also to develop a technique that would allow the identification of radical damaged biomolecules with mass spectrometry imaging. Only a very low intensity peak could be assigned to a possible radical oxidation. The main conclusion of these experiments is that the mass spectrometry imaging (MSI) used might not have enough sensitivity and mass resolution to study these low intensity peaks. The hypothesis that spin traps and spin scavengers could be exploited with other techniques was explored in this thesis in different ways without promising results. Advisors/Committee Members: PRENANT, CHRISTIAN C, WILLIAMS, KAYE KJ, Mcmahon, Adam, Prenant, Christian, Williams, Kaye.

Subjects/Keywords: oxidative damage; radiotherapy; PET; MSI; molecular imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carrascal Minino, A. (2019). The use of spin traps and spin scavengers for imaging oxidative damage. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:319465

Chicago Manual of Style (16^th Edition):

Carrascal Minino, Amaia. “The use of spin traps and spin scavengers for imaging oxidative damage.” 2019. Doctoral Dissertation, University of Manchester. Accessed January 15, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:319465.

MLA Handbook (7^th Edition):

Carrascal Minino, Amaia. “The use of spin traps and spin scavengers for imaging oxidative damage.” 2019. Web. 15 Jan 2021.

Vancouver:

Carrascal Minino A. The use of spin traps and spin scavengers for imaging oxidative damage. [Internet] [Doctoral dissertation]. University of Manchester; 2019. [cited 2021 Jan 15]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:319465.

Council of Science Editors:

Carrascal Minino A. The use of spin traps and spin scavengers for imaging oxidative damage. [Doctoral Dissertation]. University of Manchester; 2019. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:319465

20. Shi, Wei. Multimodality Photoacoustic and Raman Imaging.

Degree: PhD, Department of Electrical and Computer Engineering, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/c00000016h

► Tumor metastasis is referred to the spread of cancer from one to another unadjacent part of the body, which results in more than 90% of… (more)

▼ Tumor metastasis is referred to the spread of cancer from one to another unadjacent part of the body, which results in more than 90% of tumor deaths, and however is still poorly understood. Circulating tumor cells (CTCs) have been proposed as an important biomarker of tumor metastasis. Many approaches have been developed for detection of CTCs, but each has its own advantages and disadvantages. With the aid of nanoparticles (NPs), photoacoustic detection along with efficient magnetic enrichment of CTCs demonstrated high sensitivity. However, differentiation of photoacoustic signals is non-trivial hence specificity can be poor. Surface-enhanced-Raman-scattering (SERS) NPs were used for detection of CTCs with high multiplexing capability. However, the lack of enrichment of CTCs limits its application for in vivo detection. High sensitivity and high specificity in vivo methods of detecting CTCs are in urgent need. A hallmark signature of metastasis is angiogenesis, the proliferation of vessel networks growing from pre-existing vasculature. Imaging angiogenesis is important for cancer research since angiogenesis is regarded as a necessity for tumor growth and tumor metastasis. Photoacoustic imaging (PAM) is a promising technique for imaging angiogenesis due to intrinsic high optical contrast between blood and tissues, and high spatial resolution at adequate penetration depth. Optical-resolution photoacoustic imaging (OR-PAM) pushed the lateral resolution limit of PAM to micron or submicron level, which enables imaging of single capillaries, the finest vasculature elements. However, the low imaging speed of OR-PAM may limit its application in the clinic, and for practical pre-clinical imaging of animal models. A single modality tool for studies on tumor metastasis is unlikely to be able to fullfill these needs. Therefore, the long term goal of this dissertation is to develop a multimodality imaging tool for imaging tumor metastasis and detecting of CTCs with high specificity and high sensitivity. Specially, we focused on the approach of combing PAM with a Raman imaging technology for this purpose. For the task of detecting CTCs, the photoacoustic subsystem could aid in placement of a magnet for trapping of such CTCs and gaging the flow rate for optimal optical and multiplexed detection with the Raman sub-system. The photoacoustic sub-system could also be used for detecting absorption signatures from nanoparticles on tumor cells. For detecting metastases, the Raman imaging subsystem could be used to detect multiple flavors of nanoparticles targeted to (non-circulating) tumor cells and the photoacoustic sub-system could be used to detect neoplasm angiogenesis. We aimed to push limits of OR-PAM imaging frame-rate, to develop a novel CTC detection technique with high sensitivity and high specificity, and to further build a multimodality photoacoustic-Raman imaging tool for high sensitivity and high specificity molecular imaging. Our work presented in this dissertation can be divided into three parts. First, we worked on…

Subjects/Keywords: realtime imaging; surface-enhanced-Raman-scattering; photoacoustic microscopy; optical-resolution photoacoustic microscopy

11 more images…

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APA (6^th Edition):

Shi, W. (2014). Multimodality Photoacoustic and Raman Imaging. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c00000016h

Chicago Manual of Style (16^th Edition):

Shi, Wei. “Multimodality Photoacoustic and Raman Imaging.” 2014. Doctoral Dissertation, University of Alberta. Accessed January 15, 2021. https://era.library.ualberta.ca/files/c00000016h.

MLA Handbook (7^th Edition):

Shi, Wei. “Multimodality Photoacoustic and Raman Imaging.” 2014. Web. 15 Jan 2021.

Vancouver:

Shi W. Multimodality Photoacoustic and Raman Imaging. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2021 Jan 15]. Available from: https://era.library.ualberta.ca/files/c00000016h.

Council of Science Editors:

Shi W. Multimodality Photoacoustic and Raman Imaging. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/c00000016h

UCLA

21. Ye, Hu. Developing Methods for Quantitative PET: Application to Multimodal Human and Rat Brain Imaging.

Degree: Molec & Med Pharmacology, 2014, UCLA

URL: http://www.escholarship.org/uc/item/57572858

► Positron Emission Tomography (PET) is a functional medical imaging tool that enables the visualization of radio-labeled biologically active molecules (tracer) distributed inside a living body.… (more)

▼ Positron Emission Tomography (PET) is a functional medical imaging tool that enables the visualization of radio-labeled biologically active molecules (tracer) distributed inside a living body. PET is also combined with other modalities such as CT and MRI with either software or hardware methods to gain synergy. However numerous technical and biological issues remain to be addressed to improve the utility of PET in multimodal imaging for both clinical and preclinical applications. Patient movement during the PET/CT dynamic scan is one of the major problems in clinical study and automated MRI template-based volume of interest (VOI) analysis is one of the key issues in preclinical brain studies for PET. PET/CT is an imaging system that combines PET and CT, in which CT not only provides structure information but also aids attenuation correction for PET. This multimodal medical imaging has become prevalence in clinical diagnosis. However, head movements occurring during PET/CT dynamic scans can create large artifacts in CT-based attenuation corrected PET due to mismatches between CT and PET images. We have thus developed an automated movement correction (MC) procedure for PET/CT dynamic brain scans. MC method was first validated in a Hoffman phantom study and further evaluated with patient FDDNP (a tracer that binds beta-amyloid and tau-protein depositions in tissue) and FDG (a glucose analogue) scans. Results showed that the use of MC for PET/CT dynamic scan significantly improved image quality and allowed more accurate tracer quantitative analysis.To accurately analyze longitudinal FDG preclinical PET brain scans, especially to quantitate image values in small brain structures, an automated MRI template-based volume of interest (VOI) analysis method has been established. The method was applied to longitudinal rat brain FDG PET images to evaluate regional cerebral metabolic change that could not be done without such a template-based analysis methodology. A 6-month study in normal young adult rats showed stable FDG uptake in sensorimotor cortex and lateral prefrontal cortex, a linear decline of relative FDG uptake in striatum, hippocampus and medial prefrontal cortex, while a linear increase in the relative FDG uptake was observed in cerebellum and brain stem. This linear progressive change in regional brain metabolism is first elucidated in normal young adult rats. The method was also applied to rat brain FDG PET images to evaluate the acute and long-term effects of chemotherapy on regional cerebral metabolism.

Subjects/Keywords: Pharmacology; Medical imaging and radiology; Biomedical engineering; Brain Imaging; Multimodal; PET

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APA (6^th Edition):

Ye, H. (2014). Developing Methods for Quantitative PET: Application to Multimodal Human and Rat Brain Imaging. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/57572858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ye, Hu. “Developing Methods for Quantitative PET: Application to Multimodal Human and Rat Brain Imaging.” 2014. Thesis, UCLA. Accessed January 15, 2021. http://www.escholarship.org/uc/item/57572858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ye, Hu. “Developing Methods for Quantitative PET: Application to Multimodal Human and Rat Brain Imaging.” 2014. Web. 15 Jan 2021.

Vancouver:

Ye H. Developing Methods for Quantitative PET: Application to Multimodal Human and Rat Brain Imaging. [Internet] [Thesis]. UCLA; 2014. [cited 2021 Jan 15]. Available from: http://www.escholarship.org/uc/item/57572858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ye H. Developing Methods for Quantitative PET: Application to Multimodal Human and Rat Brain Imaging. [Thesis]. UCLA; 2014. Available from: http://www.escholarship.org/uc/item/57572858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rochester Institute of Technology

22. Schug, Nicholas C. Modular Synthesis of Dual- and Tri-modal Targeted Molecular Imaging Agents.

Degree: MS, School of Chemistry and Materials Science (COS), 2020, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/10424

► There are few reported methods for combining two or three different imaging dyes, metals, or dye-metal combinations, followed by the conjugation of a disease-… (more)

Subjects/Keywords: Cancer detection; Imaging agents; Molecular imaging; MRI; PET

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APA (6^th Edition):

Schug, N. C. (2020). Modular Synthesis of Dual- and Tri-modal Targeted Molecular Imaging Agents. (Masters Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/10424

Chicago Manual of Style (16^th Edition):

Schug, Nicholas C. “Modular Synthesis of Dual- and Tri-modal Targeted Molecular Imaging Agents.” 2020. Masters Thesis, Rochester Institute of Technology. Accessed January 15, 2021. https://scholarworks.rit.edu/theses/10424.

MLA Handbook (7^th Edition):

Schug, Nicholas C. “Modular Synthesis of Dual- and Tri-modal Targeted Molecular Imaging Agents.” 2020. Web. 15 Jan 2021.

Vancouver:

Schug NC. Modular Synthesis of Dual- and Tri-modal Targeted Molecular Imaging Agents. [Internet] [Masters thesis]. Rochester Institute of Technology; 2020. [cited 2021 Jan 15]. Available from: https://scholarworks.rit.edu/theses/10424.

Council of Science Editors:

Schug NC. Modular Synthesis of Dual- and Tri-modal Targeted Molecular Imaging Agents. [Masters Thesis]. Rochester Institute of Technology; 2020. Available from: https://scholarworks.rit.edu/theses/10424

University of Manchester

23. Armstrong, Ian. Quantitative accuracy of iterative reconstruction algorithms in positron emission tomography.

Degree: PhD, 2017, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/quantitative-accuracy-of-iterative-reconstruction-algorithms-in-positron-emission-tomography(512320eb-05dc-4ea5-999f-03be55de362d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703034

► Positron Emission Tomography (PET) plays an essential role in the management of patients with cancer. It is used to detect and characterise malignancy as well… (more)

Subjects/Keywords: 616.07; Oncology; Medical Imaging; Image Reconstruction; PET imaging

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APA (6^th Edition):

Armstrong, I. (2017). Quantitative accuracy of iterative reconstruction algorithms in positron emission tomography. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/quantitative-accuracy-of-iterative-reconstruction-algorithms-in-positron-emission-tomography(512320eb-05dc-4ea5-999f-03be55de362d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703034

Chicago Manual of Style (16^th Edition):

Armstrong, Ian. “Quantitative accuracy of iterative reconstruction algorithms in positron emission tomography.” 2017. Doctoral Dissertation, University of Manchester. Accessed January 15, 2021. https://www.research.manchester.ac.uk/portal/en/theses/quantitative-accuracy-of-iterative-reconstruction-algorithms-in-positron-emission-tomography(512320eb-05dc-4ea5-999f-03be55de362d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703034.

MLA Handbook (7^th Edition):

Armstrong, Ian. “Quantitative accuracy of iterative reconstruction algorithms in positron emission tomography.” 2017. Web. 15 Jan 2021.

Vancouver:

Armstrong I. Quantitative accuracy of iterative reconstruction algorithms in positron emission tomography. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Jan 15]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/quantitative-accuracy-of-iterative-reconstruction-algorithms-in-positron-emission-tomography(512320eb-05dc-4ea5-999f-03be55de362d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703034.

Council of Science Editors:

Armstrong I. Quantitative accuracy of iterative reconstruction algorithms in positron emission tomography. [Doctoral Dissertation]. University of Manchester; 2017. Available from: https://www.research.manchester.ac.uk/portal/en/theses/quantitative-accuracy-of-iterative-reconstruction-algorithms-in-positron-emission-tomography(512320eb-05dc-4ea5-999f-03be55de362d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703034

University of Edinburgh

24. Jenkins, William Stephen Arthur. Novel applications of positron emission tomography in the non-invasive assessment of cardiovascular disease.

Degree: PhD, 2018, University of Edinburgh

URL: http://hdl.handle.net/1842/31229

► Introduction. Fused Positron Emission Tomography and Computed Tomography (PET/CT) is an emerging investigative tool in cardiovascular disease that provides an imaging-based quantification of pathophysiological processes… (more)

▼ Introduction. Fused Positron Emission Tomography and Computed Tomography (PET/CT) is an emerging investigative tool in cardiovascular disease that provides an imaging-based quantification of pathophysiological processes of interest. The purpose of this thesis was to study the application of PET to identify fundamental pathophysiological processes driving 3 forms of cardiovascular disease: aortic stenosis, myocardial infarction, and atherosclerosis. Methods. Aortic Stenosis. Patients with a spectrum of calcific aortic valve disease (n=121) who underwent PET-CT imaging for the identification of valvular calcification (18Ffluoride) and inflammation (18F-fluorodeoxyglucose, 18F-FDG) underwent serial imaging and clinical follow-up over 2 years. Baseline imaging findings were compared with echocardiographic and CT markers of disease progression and clinical outcome. Myocardial Infarction. Patients underwent PET-CT imaging with 18F-fluciclatide (a novel αvβ3-selective radiotracer highlighting active angiogenesis, inflammation and fibrosis) after ST-segment elevation MI (n=21), alongside stable patients with chronic total occlusion (CTO) of a major coronary vessel (n=7), and healthy volunteers (n=9). Myocardial radiotracer uptake was compared with clinical and cardiac magnetic resonance imaging (CMR) markers of infarction and remodeling. Atherosclerosis. Patients with a spectrum of atherosclerotic disease categorized as stable or unstable (recent MI) underwent PET/CT imaging with 18F-fluciclatide (n=46). Thoracic aortic 18F-fluciclatide uptake was compared with aortic atherosclerotic burden quantified by CT plaque thickness, plaque volume and calcium scoring. Histological validation. Tissue from the aortic valve, myocardium and carotid arteries of study subjects was acquired and examined ex vivo using histology and autoradiography. Results. Aortic Stenosis. Baseline valvular 18F-fluoride uptake correlated strongly with the rate of progression in AVC (r=0.80, p < 0.001) and with haemodynamic progression (mean aortic valve gradient r=0.32, p=0.001). It emerged as independently associated with clinical outcome after age and sex-adjustment (HR 1.55 [1.33-1.81], p < 0.001). 18F-FDG demonstrated moderate correlations with disease progression as assessed by CT (r=0.43, p=0.001) and echocardiography (18F-FDG r=0.30, p=0.001), and was associated with clinical outcomes independent of age and sex (HR 1.35 [1.16-1.58], p < 0.001). Valvular 18F-fluoride uptake correlated with immunohistochemical markers of calcification activity. There was no correlation between 18F-FDG uptake and inflammation. Myocardial Infarction. 18F-Fluciclatide binding was demonstrated in ex vivo peri-infarct myocardium and uptake was increased in vivo at sites of acute infarction compared to remote myocardium (tissue-to-background ratio (TBRmean) 1.34±0.22 vs 0.85±0.17 respectively, p < 0.001) and myocardium of healthy volunteers (TBRmean 1.34±0.22 vs 0.70±0.03; p < 0.001). There was no 18F-fluciclatide uptake at sites of established prior infarction in patients…

Subjects/Keywords: 616.1; positron emission tomography; cardiovascular disease; PET/CT imaging; calcification; heart muscle repair; PET scanning

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APA (6^th Edition):

Jenkins, W. S. A. (2018). Novel applications of positron emission tomography in the non-invasive assessment of cardiovascular disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/31229

Chicago Manual of Style (16^th Edition):

Jenkins, William Stephen Arthur. “Novel applications of positron emission tomography in the non-invasive assessment of cardiovascular disease.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed January 15, 2021. http://hdl.handle.net/1842/31229.

MLA Handbook (7^th Edition):

Jenkins, William Stephen Arthur. “Novel applications of positron emission tomography in the non-invasive assessment of cardiovascular disease.” 2018. Web. 15 Jan 2021.

Vancouver:

Jenkins WSA. Novel applications of positron emission tomography in the non-invasive assessment of cardiovascular disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1842/31229.

Council of Science Editors:

Jenkins WSA. Novel applications of positron emission tomography in the non-invasive assessment of cardiovascular disease. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/31229

University of South Florida

25. Zhou, Fenger. Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes.

Degree: 2014, University of South Florida

URL: https://scholarcommons.usf.edu/etd/5339

► ABSTRACT Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor, which plays a pivotal part in the development of the central nervous system. Aberrant expression… (more)

Subjects/Keywords: Fluorine Capture; Kinase Inhibitor; PET imaging; PET Probe; Triazines; Chemistry; Organic Chemistry

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APA (6^th Edition):

Zhou, F. (2014). Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/5339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Fenger. “Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes.” 2014. Thesis, University of South Florida. Accessed January 15, 2021. https://scholarcommons.usf.edu/etd/5339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Fenger. “Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes.” 2014. Web. 15 Jan 2021.

Vancouver:

Zhou F. Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes. [Internet] [Thesis]. University of South Florida; 2014. [cited 2021 Jan 15]. Available from: https://scholarcommons.usf.edu/etd/5339.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou F. Synthesis of [1,2,4]-Triazines as Kinase Inhibitors and of Novel Fluorine Capture Reagents for PET probes. [Thesis]. University of South Florida; 2014. Available from: https://scholarcommons.usf.edu/etd/5339

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

26. Evans, Eleanor. Improved quantification in small animal PET/MR.

Degree: PhD, 2015, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/252640https://www.repository.cam.ac.uk/bitstream/1810/252640/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/3/Thesis_corrected_FINAL.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/4/Thesis_corrected_FINAL.pdf.jpg

► In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a… (more)

▼ In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a result of disease progression. The combination of magnetic resonance imaging (MRI) and positron emission tomography (PET) provides excellent soft tissue contrast from MRI with exceptional sensitivity and specificity from PET. This thesis explores the use of sequentially acquired PET and MR images to improve the quantification of small animal PET data. The primary focus was to improve image-based estimates of the arterial input function (AIF), which defines the amount of PET tracer within blood plasma over time. The AIF is required to produce physiological parameters quantifying key processes such as metabolism or perfusion from dynamic PET images. The gold standard for AIF measurement, however, requires serial blood sampling over the course of a PET scan, which is invasive in rat studies but prohibitive in mice due to small total blood volumes. To address this issue, the geometric transfer matrix (GTM) and recovery coefficient (RC) techniques were applied using anatomical MR images to enable the extraction of partial volume corrected image based AIFs from mouse PET images. A non-invasive AIF extraction method was also developed for rats, beginning with the optimization of an automated voxel selection algorithm to assist in extracting MR contrast agent signal time courses from dynamic susceptibility contrast (DSC) MRI data. This procedure was then combined with dynamic contrast enhanced (DCE) MRI to track a combined injection of Gadolinium-based contrast agent and PET tracer through the rat brain. By comparison with gold standard tracer blood sample data, it was found that normalized MRI-based AIFs could be successfully converted into PET tracer AIFs in the first pass phase when fitted with gamma variate functions. Finally, a MR image segmentation method used to provide PET attenuation correction in mice was validated using the Cambridge split magnet PET/MR scanner’s transmission scanning capabilities. This work recommends that contributions from MR hardware in the PET field of view must be accounted forto gain accurate estimates of tracer uptake and standard uptake values (SUVs). This thesis concludes that small animal MR data taken in the same imaging session can provide non-invasive methods to improve PET image quantification, giving added value to combined PET/MR studies over those conducted using PET alone.

Subjects/Keywords: Magnetic Resonance Imaging; MRI; Positron Emission Tomography; PET; Animal imaging; Arterial Input Function; Partial Volume Correction; Medical Physics; Attenuation Correction; Perfusion Imaging; Compartmental Modelling; Dynamic Imaging; PET/MR Imaging

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APA (6^th Edition):

Evans, E. (2015). Improved quantification in small animal PET/MR. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/252640https://www.repository.cam.ac.uk/bitstream/1810/252640/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/3/Thesis_corrected_FINAL.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/4/Thesis_corrected_FINAL.pdf.jpg

Chicago Manual of Style (16^th Edition):

Evans, Eleanor. “Improved quantification in small animal PET/MR.” 2015. Doctoral Dissertation, University of Cambridge. Accessed January 15, 2021. https://www.repository.cam.ac.uk/handle/1810/252640https://www.repository.cam.ac.uk/bitstream/1810/252640/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/3/Thesis_corrected_FINAL.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/4/Thesis_corrected_FINAL.pdf.jpg.

MLA Handbook (7^th Edition):

Evans, Eleanor. “Improved quantification in small animal PET/MR.” 2015. Web. 15 Jan 2021.

Vancouver:

Evans E. Improved quantification in small animal PET/MR. [Internet] [Doctoral dissertation]. University of Cambridge; 2015. [cited 2021 Jan 15]. Available from: https://www.repository.cam.ac.uk/handle/1810/252640https://www.repository.cam.ac.uk/bitstream/1810/252640/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/3/Thesis_corrected_FINAL.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/4/Thesis_corrected_FINAL.pdf.jpg.

Council of Science Editors:

Evans E. Improved quantification in small animal PET/MR. [Doctoral Dissertation]. University of Cambridge; 2015. Available from: https://www.repository.cam.ac.uk/handle/1810/252640https://www.repository.cam.ac.uk/bitstream/1810/252640/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/3/Thesis_corrected_FINAL.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/252640/4/Thesis_corrected_FINAL.pdf.jpg

University of Cambridge

27. Evans, Eleanor. Improved quantification in small animal PET/MR.

Degree: PhD, 2015, University of Cambridge

URL: https://doi.org/10.17863/CAM.13949 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675897

► In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a… (more)

▼ In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a result of disease progression. The combination of magnetic resonance imaging (MRI) and positron emission tomography (PET) provides excellent soft tissue contrast from MRI with exceptional sensitivity and specificity from PET. This thesis explores the use of sequentially acquired PET and MR images to improve the quantification of small animal PET data. The primary focus was to improve image-based estimates of the arterial input function (AIF), which defines the amount of PET tracer within blood plasma over time. The AIF is required to produce physiological parameters quantifying key processes such as metabolism or perfusion from dynamic PET images. The gold standard for AIF measurement, however, requires serial blood sampling over the course of a PET scan, which is invasive in rat studies but prohibitive in mice due to small total blood volumes. To address this issue, the geometric transfer matrix (GTM) and recovery coefficient (RC) techniques were applied using anatomical MR images to enable the extraction of partial volume corrected image based AIFs from mouse PET images. A non-invasive AIF extraction method was also developed for rats, beginning with the optimization of an automated voxel selection algorithm to assist in extracting MR contrast agent signal time courses from dynamic susceptibility contrast (DSC) MRI data. This procedure was then combined with dynamic contrast enhanced (DCE) MRI to track a combined injection of Gadolinium-based contrast agent and PET tracer through the rat brain. By comparison with gold standard tracer blood sample data, it was found that normalized MRI-based AIFs could be successfully converted into PET tracer AIFs in the first pass phase when fitted with gamma variate functions. Finally, a MR image segmentation method used to provide PET attenuation correction in mice was validated using the Cambridge split magnet PET/MR scanner?s transmission scanning capabilities. This work recommends that contributions from MR hardware in the PET field of view must be accounted forto gain accurate estimates of tracer uptake and standard uptake values (SUVs). This thesis concludes that small animal MR data taken in the same imaging session can provide non-invasive methods to improve PET image quantification, giving added value to combined PET/MR studies over those conducted using PET alone.

Subjects/Keywords: 612.8; Magnetic Resonance Imaging; MRI; Positron Emission Tomography; PET; Animal imaging; Arterial Input Function; Partial Volume Correction; Medical Physics; Attenuation Correction; Perfusion Imaging; Compartmental Modelling; Dynamic Imaging; PET/MR Imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Evans, E. (2015). Improved quantification in small animal PET/MR. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.13949 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675897

Chicago Manual of Style (16^th Edition):

Evans, Eleanor. “Improved quantification in small animal PET/MR.” 2015. Doctoral Dissertation, University of Cambridge. Accessed January 15, 2021. https://doi.org/10.17863/CAM.13949 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675897.

MLA Handbook (7^th Edition):

Evans, Eleanor. “Improved quantification in small animal PET/MR.” 2015. Web. 15 Jan 2021.

Vancouver:

Evans E. Improved quantification in small animal PET/MR. [Internet] [Doctoral dissertation]. University of Cambridge; 2015. [cited 2021 Jan 15]. Available from: https://doi.org/10.17863/CAM.13949 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675897.

Council of Science Editors:

Evans E. Improved quantification in small animal PET/MR. [Doctoral Dissertation]. University of Cambridge; 2015. Available from: https://doi.org/10.17863/CAM.13949 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675897

UCLA

28. Gu, Zheng. Towards High Sensitivity and High Spatial Resolution Positron Emission Tomography Imaging.

Degree: Biomedical Physics, 2014, UCLA

URL: http://www.escholarship.org/uc/item/4mp632hr

► High sensitivity and high resolution have been pursued as some of the most important research goals for preclinical Positron Emission Tomography (PET) imaging. PETbox4, a… (more)

▼ High sensitivity and high resolution have been pursued as some of the most important research goals for preclinical Positron Emission Tomography (PET) imaging. PETbox4, a new, fully tomographic bench top PET scanner dedicated for mouse imaging, was designed and developed in this work. The aim of the PETbox4 scanner is to achieve very high sensitivity and produce high quality PET tomographic images for molecular imaging based biomedical research. Performance of the prototype PETbox4 system was characterized using the National Electrical Manufacturers Association (NEMA) NU 4-2008 standards. Due to the different characteristics caused by the compact geometrical factors, PETbox4 requires data acquisition protocols that differ from those optimized for conventional large diameter ring systems. In this work the energy window for data acquisitions with PETbox4 was optimized using the Geant4 Application for Tomographic Emission (GATE) simulation. A lower level discriminator (LLD) of 350 keV was proposed as the optimized energy threshold. Pulse pileup is a common problem in multiplexed scintillator detectors readout by resistor divider networks. In this work, a new pileup rejection method named position shift rejection (PSR) is introduced. The PSR method is based on the detection of position shifts on event location as the signal is being integrated. Both simulations and physical measurements show that PSR performs more accurate rejection and avoids erroneous rejection and loss of sensitivity compared to the conventional leading edge rejection (LER) method.A new phoswich DOI Detector with crystal scatter identification capability is being designed and developed for implementation in a next generation small animal PET system at UCLA. Both simulations and measurements were performed to evaluate the characteristics and benefits of the proposed design. In conclusion, these results demonstrate that the proposed detector is feasible and can potentially lead to a high spatial resolution, high sensitivity and DOI PET system.

Subjects/Keywords: Biomedical engineering; Nuclear engineering; Medical imaging and radiology; detector; imaging; PET; preclinical; sensitivity; spatial resolution

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gu, Z. (2014). Towards High Sensitivity and High Spatial Resolution Positron Emission Tomography Imaging. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/4mp632hr

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gu, Zheng. “Towards High Sensitivity and High Spatial Resolution Positron Emission Tomography Imaging.” 2014. Thesis, UCLA. Accessed January 15, 2021. http://www.escholarship.org/uc/item/4mp632hr.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gu, Zheng. “Towards High Sensitivity and High Spatial Resolution Positron Emission Tomography Imaging.” 2014. Web. 15 Jan 2021.

Vancouver:

Gu Z. Towards High Sensitivity and High Spatial Resolution Positron Emission Tomography Imaging. [Internet] [Thesis]. UCLA; 2014. [cited 2021 Jan 15]. Available from: http://www.escholarship.org/uc/item/4mp632hr.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gu Z. Towards High Sensitivity and High Spatial Resolution Positron Emission Tomography Imaging. [Thesis]. UCLA; 2014. Available from: http://www.escholarship.org/uc/item/4mp632hr

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rochester Institute of Technology

29. Jones, Kelsea. Modular Synthesis of Targeted Molecular Imaging Agents for MRI, PET, and PET-MRI of Cancer.

Degree: MS, School of Chemistry and Materials Science (COS), 2019, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/10123

► Molecular imaging is a field widely used in the diagnosis and treatment of cancer. We offer here a modular method for the synthesis of… (more)

Subjects/Keywords: Magnetic resonance imaging (MRI); Organometallic synthesis; Positron emission tomography (PET); Targeted molecular imaging agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jones, K. (2019). Modular Synthesis of Targeted Molecular Imaging Agents for MRI, PET, and PET-MRI of Cancer. (Masters Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/10123

Chicago Manual of Style (16^th Edition):

Jones, Kelsea. “Modular Synthesis of Targeted Molecular Imaging Agents for MRI, PET, and PET-MRI of Cancer.” 2019. Masters Thesis, Rochester Institute of Technology. Accessed January 15, 2021. https://scholarworks.rit.edu/theses/10123.

MLA Handbook (7^th Edition):

Jones, Kelsea. “Modular Synthesis of Targeted Molecular Imaging Agents for MRI, PET, and PET-MRI of Cancer.” 2019. Web. 15 Jan 2021.

Vancouver:

Jones K. Modular Synthesis of Targeted Molecular Imaging Agents for MRI, PET, and PET-MRI of Cancer. [Internet] [Masters thesis]. Rochester Institute of Technology; 2019. [cited 2021 Jan 15]. Available from: https://scholarworks.rit.edu/theses/10123.

Council of Science Editors:

Jones K. Modular Synthesis of Targeted Molecular Imaging Agents for MRI, PET, and PET-MRI of Cancer. [Masters Thesis]. Rochester Institute of Technology; 2019. Available from: https://scholarworks.rit.edu/theses/10123

Wayne State University

30. Bonomi, Robin Edwards. Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation.

Degree: PhD, Biomedical Engineering, 2016, Wayne State University

URL: https://digitalcommons.wayne.edu/oa_dissertations/1519

► Over the past two decades, epigenetic regulation has become a rapidly growing, highly innovative and influential field of biology and medicine. Protein acetylation and… (more)

▼ Over the past two decades, epigenetic regulation has become a rapidly growing, highly innovative and influential field of biology and medicine. Protein acetylation and deacetylation, two key epigenetic regulatory mechanisms, are mediated by histone acetylase transferases (HATs) and histone deacetylases (HDACs), respectively. To date, the vast majority of studies on epigenetic regulation have been conducted in cell cultures and tissue samples using conventional methodologies of molecular and cellular biology, which contain inherent limitations for monitoring therapy and disease. Therefore, there is a growing need for novel, advanced methodologies that allow for non-invasive detection and monitoring of HDAC–mediated epigenetic regulatory processes in different organs and tissues. One such methodology is molecular imaging with positron emission tomography (PET), which allows for non-invasive visualization and quantification of spatial and temporal dynamics of expression-activity of various receptors and enzymes in different organs and tissues in norm and disease. The availability of selective substrates to various classes and isoforms of HDACs would enable the development of radiolabeled imaging agents for non-invasive in vivo PET imaging. Therefore, the aim of this work is to develop class- and/or isoform-selective radiolabeled substrates of HDACs, with particular emphasis on class III (sirtuins, SIRTs). Herein, HDAC class IIa, SIRT1 and SIRT2-selective radiotracers have been developed and validated through in vitro and in vivo characterization. Two of these tracers, 18F-TFAHA for HDAC class IIa and and 2-[18F]PhAHA for SIRT1, have also been validated in a disease model demonstrating their utility in understanding epigenetic regulation in an aggressive form of brain cancer. The development of these targeted imaging agents may help develop new therapies for disease as well as methodologies for monitoring treatment effectiveness and disease progression. Advisors/Committee Members: Juri G. Gelovani.

Subjects/Keywords: Epigenetic Regulation; Epigenetics; HDAC; Molecular Imaging; PET Imaging; Sirtuins; Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bonomi, R. E. (2016). Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation. (Doctoral Dissertation). Wayne State University. Retrieved from https://digitalcommons.wayne.edu/oa_dissertations/1519

Chicago Manual of Style (16^th Edition):

Bonomi, Robin Edwards. “Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation.” 2016. Doctoral Dissertation, Wayne State University. Accessed January 15, 2021. https://digitalcommons.wayne.edu/oa_dissertations/1519.

MLA Handbook (7^th Edition):

Bonomi, Robin Edwards. “Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation.” 2016. Web. 15 Jan 2021.

Vancouver:

Bonomi RE. Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation. [Internet] [Doctoral dissertation]. Wayne State University; 2016. [cited 2021 Jan 15]. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1519.

Council of Science Editors:

Bonomi RE. Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation. [Doctoral Dissertation]. Wayne State University; 2016. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1519

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Open Access Theses and Dissertations