subject:(Rats)

University of Georgia

1. Scherer, Isabell Juliane. The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system.

Degree: MS, Foods and Nutrition, 2009, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms

► Rats exposed to repeated restraint (RR) lose weight and do not return to the weight of nonstressed controls (CTRL). This study tested the effect of… (more)

Subjects/Keywords: rats

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APA (6^th Edition):

Scherer, I. J. (2009). The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms

Chicago Manual of Style (16^th Edition):

Scherer, Isabell Juliane. “The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system.” 2009. Masters Thesis, University of Georgia. Accessed October 22, 2018. http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms.

MLA Handbook (7^th Edition):

Scherer, Isabell Juliane. “The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system.” 2009. Web. 22 Oct 2018.

Vancouver:

Scherer IJ. The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system. [Internet] [Masters thesis]. University of Georgia; 2009. [cited 2018 Oct 22]. Available from: http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms.

Council of Science Editors:

Scherer IJ. The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system. [Masters Thesis]. University of Georgia; 2009. Available from: http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms

2. Po, Chrystelle. Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat.

Degree: Docteur es, Chimie, 2009, Evry-Val d'Essonne

URL: http://www.theses.fr/2009EVRY0002

►

Le but de cette étude était de caractériser par IRM et SRM in vivo le développement à court et moyen terme des atteintes cérébrales consécutives… (more)

Subjects/Keywords: Rats

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APA (6^th Edition):

Po, C. (2009). Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat. (Doctoral Dissertation). Evry-Val d'Essonne. Retrieved from http://www.theses.fr/2009EVRY0002

Chicago Manual of Style (16^th Edition):

Po, Chrystelle. “Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat.” 2009. Doctoral Dissertation, Evry-Val d'Essonne. Accessed October 22, 2018. http://www.theses.fr/2009EVRY0002.

MLA Handbook (7^th Edition):

Po, Chrystelle. “Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat.” 2009. Web. 22 Oct 2018.

Vancouver:

Po C. Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat. [Internet] [Doctoral dissertation]. Evry-Val d'Essonne; 2009. [cited 2018 Oct 22]. Available from: http://www.theses.fr/2009EVRY0002.

Council of Science Editors:

Po C. Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat. [Doctoral Dissertation]. Evry-Val d'Essonne; 2009. Available from: http://www.theses.fr/2009EVRY0002

University of Hawaii

3. Fial, Ronald Augustine. Hippocampal structure and function in the albino rat.

Degree: PhD, 2009, University of Hawaii

URL: http://hdl.handle.net/10125/11911

►

Typescript.

Bibliography: leaves [74]-79.

viii, 79 l illus., charts, tables

Theories concerning the function of the hippocampus in behavior have treated this structure as being… (more)

▼

Typescript.

Bibliography: leaves [74]-79.

viii, 79 l illus., charts, tables

Theories concerning the function of the hippocampus in behavior have treated this structure as being homogenous in function. Inconsistencies in prior research have sometimes been attributed to differences in procedures or to extra-hippocampal damage resulting from the manipulation. While these factors have been shown to be potent variables, several writers have suggested that lesion location within the hippocampus is important and that smaller lesions are to be preferred to the generally large ones used in most earlier work. Recent work involving the organization of afferent and efferent pathways of the hippocampus has shown these to be well organized in terms of the various "fields" of the structure as distinguished by early anatomists. In the present experiment 14 control operated (HC), 14 hippocampally lesioned (BE), 16 dorsal fornix lesioned (DF) and 16 lateral fimbria lesioned (LF) albino rats were tested in a series of five behavioral tasks in order to assess the relative behavioral effects of gross hippocampal lesions and lesions of the hippocampal efferent pathways. No group differences were found in open field activity levels, or in number of approaches to novel ob.1ects placed in an open field. In an orienting shift task with subjects under 23-hour water deprivation, HE, LF and DF groups had shorter initial latencies to drink than HC subjects, and the HE group made fewer orientations to light stimuli but not to tone stimuli. In a passive avoidance task the HE and LF groups made more errors than the HC. group. In addition the HE group also made more errors than the LF and DF groups. HE and LF groups fought less than the DF and HC groups in a reflexive fighting task. The LF group also demonstrated shorter boxing-posture maintenance relative to the HC and Dr groups at the end of the reflexive fighting session. All groups were similar to each other in a shock threshold rating situation, but the HE group had a lower jump threshold than the HC group. The effects of the gross lesions were similar to those obtained in previous studies. Response perseveration, internal inhibition, and stimulus gating interpretations of hippocampal function were discussed and it was concluded that the gross lesion effects were best explained on the basis of an involvement of anxiety-defensive immobility mechanisms. The pattern of results for the behavioral tasks changed markedly as a function of the efferent path lesion location. Unitary explanations were rejected, and it was concluded that anatomical differences in hippocampal projections are accompanied by separation of function. Two multi-functional interpretations were offered to account for the differences observed.

Subjects/Keywords: Rats – Anatomy; Rats – Physiology

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APA (6^th Edition):

Fial, R. A. (2009). Hippocampal structure and function in the albino rat. (Doctoral Dissertation). University of Hawaii. Retrieved from http://hdl.handle.net/10125/11911

Chicago Manual of Style (16^th Edition):

Fial, Ronald Augustine. “Hippocampal structure and function in the albino rat.” 2009. Doctoral Dissertation, University of Hawaii. Accessed October 22, 2018. http://hdl.handle.net/10125/11911.

MLA Handbook (7^th Edition):

Fial, Ronald Augustine. “Hippocampal structure and function in the albino rat.” 2009. Web. 22 Oct 2018.

Vancouver:

Fial RA. Hippocampal structure and function in the albino rat. [Internet] [Doctoral dissertation]. University of Hawaii; 2009. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/10125/11911.

Council of Science Editors:

Fial RA. Hippocampal structure and function in the albino rat. [Doctoral Dissertation]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/11911

Oregon State University

4. Tinsley, Joel Ray. The influence of vegetable fibers on mineral balance in the rat.

Degree: MS, Food Science and Technology, 1979, Oregon State University

URL: http://hdl.handle.net/1957/27195

► Dietary fiber has been suggested as interfering with mineral utilization. The influence of broccoli florets and wastes, cauliflower heads and wastes, wheat bran and Metamucil… (more)

▼ Dietary fiber has been suggested as interfering with mineral utilization. The influence of broccoli florets and wastes, cauliflower heads and wastes, wheat bran and Metamucil on mineral uptake by the rat was determined using balance studies. All results were compared to control animals fed diets containing 10% hydrolyzed cellulose. Utilization of Ca, Mg, Cu, Zn and Fe were determined to be 62, 33, 23, 42, and 52% respectively for control animals. The uptake of Mg, Zn and Fe were significantly reduced to 12, 16 and 18% respectively from broccoli florets. Broccoli wastes decreased absorption of Zn to 14% and created a negative iron balance. Cauliflower heads improved Zn assimilation to 61%. Cauliflower wastes depressed Ca absorption to 26% and caused Mg balance to be negative. Wheat bran improved utilization of Ca and Zn to 88 and 54% respectively. Metamucil increased uptake of Ca to 88% and Mg to 53%. Copper balance was unaffected by any test diet. To better understand results of balance trials, the bioavailability of Fe from some sources was measured. The relative biological values (RBV) of endogenous Fe in broccoli, cauliflower, Brussel sprouts and wheat bran were determined to be 93, 88, 83, 98% respectively. These values were obtained using rats fed control diets containing 5% hydrolyzed cellulose and ferrous sulfate (RBV = 100). The efficiency - true bioavailability of utilizing dietary Fe is approximately one-half of the RBV. These values agree well with apparent uptake of iron by animals in the balance trials for all diets except broccoli. This exception may be due to differences in the amount and source of broccoli fed. High dietary levels of broccoli florets and wastes appear to interfere with utilization of Fe and Zn. Cauliflower wastes depress absorption of Ca and Mg. With the exceptions noted, dietary fiber from plant sources does not appear to decrease the utilization of minerals by the rat. The nature of mineral complexes in plants may be more important in defining the degree of its absorption. Advisors/Committee Members: Gordon, Dennis T. (advisor).

Subjects/Keywords: Rats

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APA (6^th Edition):

Tinsley, J. R. (1979). The influence of vegetable fibers on mineral balance in the rat. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/27195

Chicago Manual of Style (16^th Edition):

Tinsley, Joel Ray. “The influence of vegetable fibers on mineral balance in the rat.” 1979. Masters Thesis, Oregon State University. Accessed October 22, 2018. http://hdl.handle.net/1957/27195.

MLA Handbook (7^th Edition):

Tinsley, Joel Ray. “The influence of vegetable fibers on mineral balance in the rat.” 1979. Web. 22 Oct 2018.

Vancouver:

Tinsley JR. The influence of vegetable fibers on mineral balance in the rat. [Internet] [Masters thesis]. Oregon State University; 1979. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/1957/27195.

Council of Science Editors:

Tinsley JR. The influence of vegetable fibers on mineral balance in the rat. [Masters Thesis]. Oregon State University; 1979. Available from: http://hdl.handle.net/1957/27195

University of North Carolina – Wilmington

5. Poerstel, L. Brooke. Evaluating equivalence relations in rats using an olfactory matching-to-sample procedure.

Degree: 2009, University of North Carolina – Wilmington

URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1761

► Equivalence classes can be characterized as groups of stimuli which control responding based on relations among members of the class, rather than absolute stimulus features… (more)

▼ Equivalence classes can be characterized as groups of stimuli which control responding based on relations among members of the class, rather than absolute stimulus features such as shape, size, or color. Formation of equivalence classes often includes conditional discrimination training, which establishes contingency relations between physically dissimilar, arbitrary stimuli using a Match-To-Sample (MTS) paradigm. If, through the conditional discrimination training, the arbitrary stimuli become members of predetermined equivalence classes, then four untrained properties of equivalence classes (identity or reflexivity, symmetry, transitivity, and equivalency) should also emerge during test configurations. Unlike humans, evidence of responding characteristic of equivalence class formation in nonhuman animals is rarely, if ever, found. Regardless, classification of environmental stimuli based on abstract, relational features may be a fundamental aspect in learning and adaptation, as well as a possible indication of nonhuman symbolic behavior. The equivalence model also provides a parsimonious account of the often complex social and communicative behaviors observed in nonhuman animals in natural settings. Perhaps traditional laboratory equivalence procedures require modification such that these behaviors may be more readily observed in nonhuman subjects. The current paper evaluated whether rats could demonstrate (1) acquisition of conditional discriminations, both identity and arbitrary, within the training framework and (2) relational responding in the presence of novel testing configurations (emergence of generalized identity matching, symmetry, transitivity, and equivalence relations) through a modified MTS procedure using olfactory stimuli and class-specific reinforcers. Three experiments were conducted to evaluate generalized identity MTS (Experiment 1), arbitrary MTS and emergent equivalence (Experiment 2), and training experience effects on emergent equivalence performance (extensive identity MTS pre-training versus no identity MTS pre-training, Experiment 3). Subjects, 11 Male HSD rats, were trained to retrieve reinforcers from cups of scented sand, which served as the stimuli throughout the experiment. Nine subjects were trained identity MTS discriminations during Experiment 1. Five of the nine demonstrated convincing evidence for generalized identity matching. The same five animals were then trained arbitrary MTS discriminations and given emergent equivalence tests during Experiment 2. Four of the five Experiment 2 subjects performed above chance during equivalence tests. Experiment 3 consisted of arbitrary MTS training with two naïve subjects that had no identity MTS experience. One Experiment 3 subject received an emergent equivalence test, but did not perform above chance levels. The results of the three experiments suggest that olfactory stimuli and class-specific reinforcers allow for transfer of responding during both generalized identity and emergent equivalence tests. The exact effect of pre-training on… Advisors/Committee Members: Mark Galizio (advisor).

Subjects/Keywords: Rats – Research

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APA (6^th Edition):

Poerstel, L. B. (2009). Evaluating equivalence relations in rats using an olfactory matching-to-sample procedure. (Masters Thesis). University of North Carolina – Wilmington. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1761

Chicago Manual of Style (16^th Edition):

Poerstel, L Brooke. “Evaluating equivalence relations in rats using an olfactory matching-to-sample procedure.” 2009. Masters Thesis, University of North Carolina – Wilmington. Accessed October 22, 2018. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1761.

MLA Handbook (7^th Edition):

Poerstel, L Brooke. “Evaluating equivalence relations in rats using an olfactory matching-to-sample procedure.” 2009. Web. 22 Oct 2018.

Vancouver:

Poerstel LB. Evaluating equivalence relations in rats using an olfactory matching-to-sample procedure. [Internet] [Masters thesis]. University of North Carolina – Wilmington; 2009. [cited 2018 Oct 22]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1761.

Council of Science Editors:

Poerstel LB. Evaluating equivalence relations in rats using an olfactory matching-to-sample procedure. [Masters Thesis]. University of North Carolina – Wilmington; 2009. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1761

University of North Carolina – Wilmington

6. Rayburn-Reeves, Rebecca M. A study of functional equivalence in rats using class-specific reinforcers and olfactory stimuli.

Degree: 2009, University of North Carolina – Wilmington

URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1714

► Functional equivalence has been demonstrated in some non-human animals using a repeated reversal simple discrimination procedure. The current study addressed the issue of stimulus equivalence… (more)

Subjects/Keywords: Rats – Research

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APA (6^th Edition):

Rayburn-Reeves, R. M. (2009). A study of functional equivalence in rats using class-specific reinforcers and olfactory stimuli. (Masters Thesis). University of North Carolina – Wilmington. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1714

Chicago Manual of Style (16^th Edition):

Rayburn-Reeves, Rebecca M. “A study of functional equivalence in rats using class-specific reinforcers and olfactory stimuli.” 2009. Masters Thesis, University of North Carolina – Wilmington. Accessed October 22, 2018. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1714.

MLA Handbook (7^th Edition):

Rayburn-Reeves, Rebecca M. “A study of functional equivalence in rats using class-specific reinforcers and olfactory stimuli.” 2009. Web. 22 Oct 2018.

Vancouver:

Rayburn-Reeves RM. A study of functional equivalence in rats using class-specific reinforcers and olfactory stimuli. [Internet] [Masters thesis]. University of North Carolina – Wilmington; 2009. [cited 2018 Oct 22]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1714.

Council of Science Editors:

Rayburn-Reeves RM. A study of functional equivalence in rats using class-specific reinforcers and olfactory stimuli. [Masters Thesis]. University of North Carolina – Wilmington; 2009. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1714

University of North Carolina – Wilmington

7. Thomas, Rhiannon D. Olfactory matching-to-sample in rats using a novel apparatus.

Degree: 2009, University of North Carolina – Wilmington

URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1670

► The present study used a semi-automated device to test olfactory matching-to-sample in rats. The apparatus was a modified operant chamber with three nose ports that… (more)

Subjects/Keywords: Rats – Research

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APA (6^th Edition):

Thomas, R. D. (2009). Olfactory matching-to-sample in rats using a novel apparatus. (Masters Thesis). University of North Carolina – Wilmington. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1670

Chicago Manual of Style (16^th Edition):

Thomas, Rhiannon D. “Olfactory matching-to-sample in rats using a novel apparatus.” 2009. Masters Thesis, University of North Carolina – Wilmington. Accessed October 22, 2018. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1670.

MLA Handbook (7^th Edition):

Thomas, Rhiannon D. “Olfactory matching-to-sample in rats using a novel apparatus.” 2009. Web. 22 Oct 2018.

Vancouver:

Thomas RD. Olfactory matching-to-sample in rats using a novel apparatus. [Internet] [Masters thesis]. University of North Carolina – Wilmington; 2009. [cited 2018 Oct 22]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1670.

Council of Science Editors:

Thomas RD. Olfactory matching-to-sample in rats using a novel apparatus. [Masters Thesis]. University of North Carolina – Wilmington; 2009. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=1670

Oregon State University

8. Shumake, James Michael. Physiology of the corpus luteum of the rat.

Degree: MS, Zoology, 1966, Oregon State University

URL: http://hdl.handle.net/1957/48002

► Rat luteal cells from functional and non-functional corpora lutea (corpora lutea rendered non-functional by hypophysectomy) were preserved for light and electron microscopy in Bouin's and… (more)

Subjects/Keywords: Rats

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APA (6^th Edition):

Shumake, J. M. (1966). Physiology of the corpus luteum of the rat. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/48002

Chicago Manual of Style (16^th Edition):

Shumake, James Michael. “Physiology of the corpus luteum of the rat.” 1966. Masters Thesis, Oregon State University. Accessed October 22, 2018. http://hdl.handle.net/1957/48002.

MLA Handbook (7^th Edition):

Shumake, James Michael. “Physiology of the corpus luteum of the rat.” 1966. Web. 22 Oct 2018.

Vancouver:

Shumake JM. Physiology of the corpus luteum of the rat. [Internet] [Masters thesis]. Oregon State University; 1966. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/1957/48002.

Council of Science Editors:

Shumake JM. Physiology of the corpus luteum of the rat. [Masters Thesis]. Oregon State University; 1966. Available from: http://hdl.handle.net/1957/48002

Oregon State University

9. Lock, Albert. The vagal inhibitory reflex in the rat stomach.

Degree: PhD, Pharmacology, 1971, Oregon State University

URL: http://hdl.handle.net/1957/45700

► Electrical stimulation of the vagus nerves produces an excitatory contraction response in the isolated rat stomach. This contraction response was abolished by atropine to unmask… (more)

▼ Electrical stimulation of the vagus nerves produces an excitatory contraction response in the isolated rat stomach. This contraction response was abolished by atropine to unmask the vagal inhibitory response (VIR) elicited during low frequency vagal stimulation. Babring and Gershon (1967), after working on guinea-pigs and mice, hypothesized that both serotonin (5-HT) and acetylcholine (ACh) are neurotransmitters acting on the same ganglion cell in the vagal inhibitory pathway. This hypothesis for the role of 5-HT was tested in the rat after the VIR of the isolated stomach was characterized. The hypothesis was tested with 5-HT depletory, parachlorophenylalanine (PCPA) and reserpine, and a ganglionic blocking agent, hexamethonium (C₆). If the hypothesized role for 5-HT is true, the depletion of 5-HT from stomach tissues should influence the VIR. Furthermore, if both 5-HT and ACh are neurotransmitters acting on the same ganglion cell in the vagal inhibitory pathway, the addition of C₆ should only block the action of ACh but not the actions of 5-HT in the ganglia. Thus, vagal stimulation after the addition of C₆, in the presence of atropine, should still produce a VIR due to the action of 5-HT. The VIR was present in all groups of rats tested and remained unchanged even though large amounts of 5-HT were depleted from the stomach tissues. The possibility still exists that the small amounts of 5-HT remaining after treatment with PCPA and reserpine could be sufficient to maintain the vagal inhibitory pathway. However, the VIR of the rat was completely abolished by C₆. These results indicate that serotonin is not involved either pre- or postganglionically in the vagal inhibitory pathway of the rat stomach. Stimulation of the vagus nerves of the in situ rat stomach elicited a gastric relaxation response in contrast to the contraction response observed with the isolated stomach. This in situ relaxation response was elicited by stimulation of the intact vagi as well as by peripheral vagal stimulation. The in situ relaxation response was characterized and an effort was made to determine the relationship between the in situ relaxation response and the VIR. Some experimental conditions which may influence the in situ relaxation response were investigated. The influence of age and sex, lowered body temperature, starvation and partial evisceration by removal of the intestines, on the in situ relaxation response were examined. None of the above conditions appeared to affect this response except the partial evisceration of the animal. The in situ relaxation response was abolished following the removal of the intestines and succeeding stimulation of the vagi elicited only gastric contractions. Subsequent treatment with guanethidine, reserpine and 6-hydroxydopamine (6- OHDA), all resulted in the reversal of the in situ relaxation response into a contraction response to vagal stimulation. Atropine abolished the contraction response to reveal the VIR. The evidence indicates that the in situ… Advisors/Committee Members: Weber, Lavern J. (advisor).

Subjects/Keywords: Rats

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APA (6^th Edition):

Lock, A. (1971). The vagal inhibitory reflex in the rat stomach. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45700

Chicago Manual of Style (16^th Edition):

Lock, Albert. “The vagal inhibitory reflex in the rat stomach.” 1971. Doctoral Dissertation, Oregon State University. Accessed October 22, 2018. http://hdl.handle.net/1957/45700.

MLA Handbook (7^th Edition):

Lock, Albert. “The vagal inhibitory reflex in the rat stomach.” 1971. Web. 22 Oct 2018.

Vancouver:

Lock A. The vagal inhibitory reflex in the rat stomach. [Internet] [Doctoral dissertation]. Oregon State University; 1971. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/1957/45700.

Council of Science Editors:

Lock A. The vagal inhibitory reflex in the rat stomach. [Doctoral Dissertation]. Oregon State University; 1971. Available from: http://hdl.handle.net/1957/45700

Oregon State University

10. Koeferl, Michael Tallyn. Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats.

Degree: PhD, Pharmacology and Toxicology, 1972, Oregon State University

URL: http://hdl.handle.net/1957/45738

► There has been no toxicologic proof that the long-term, low-level exposure of man to chlorophenothane (DDT) is linked with an increased susceptibility to toxicity or… (more)

▼ There has been no toxicologic proof that the long-term, low-level exposure of man to chlorophenothane (DDT) is linked with an increased susceptibility to toxicity or disease. Acute pretreatment of rats with 75-100 mg/kg DDT has been demonstrated to potentiate CCI₄-induced hepatotoxicity in that species (McLean and McLean, 1966). Since the hepatotoxic response to CC1₄ is similar among mammalian species, it was believed man's response could also be altered by prior exposure to DDT. Chronic pretreatment of rats with DDT more closely duplicates man's exposure situation, which is mainly dietary. Therefore, this present investigation was undertaken to quantify the DDT-CCI₄ hepatotoxic interaction in rats from the standpoint of a chronic dietary exposure to DDT. Chronic and acute pretreatments with DDT were compared for their relative effects on acute CC1₄ hepatotoxicity. Subgroups of rats fed DDT at concentrations of 6-65 ppm for three weeks and 65 ppm for 24 weeks attained body burdens of DDT and its metabolites ranging from 6.1 to 30.6 ppm, compared to 0 ppm (no detectable) for controls. In the acute study, subgroups of rats were dosed with 35-150 mg/kg DDT by gavage 24 hours prior to CC1₄ exposure. Doses of CC1₄ ranging from 0.125 to 1.0 mi./kg were administered by gavage. All pretreatments with DDT, chronic or acute, resulted in a potentiated elevation of serum transaminase (SGPT and SGOT) activities following treatment with CC1₄. The degree of potentiation was dose-related to CCI₄ and to the total DDT body burden. In a temporal study, the onset of the potentiated response was noted six hours after CC1₄. All of the above-mentioned results were confirmed by histopathology. Plasma BSP disappearance, dose-response and temporal studies were conducted in control and DDT-fed rat groups, utilizing the BSP test as an index of hepatic functional impairment, CC1₄-induced BSP retention was greatly potentiated by prior dietary exposure to DDT. This potentiation effect was obscured at a dose of 2.0 ml/kg CC1₄, due to the severe hepatic damage produced by this dose of CCI₄ given alone. The onset and development of the potentiated hepatic dysfunction paralleled that of the parenchymal cell destruction. The potentiated CC1₄-induced increases in SGOT activity and centrilobularly-oriented coagulative necrosis in the DDT-fed animals were prevented by spinal cord transection at the level of the seventh cervical vertebra. Chronic DDT pretreatment did not enhance CC1₄ uptake into the blood or livers of intact rats, and this was ruled out as a possible mechanism for the potentiation effect. Cord-sectioning did enhance tissue CC1₄ uptake, yet these animals were protected against CC1₄-induced central necrosis. Neither cord-sectioning nor the resultant hypothermia reduced the microsomal cytochrome P-450 content in control or DDT-fed rats. Hypothermia depressed the in vitro N-demethylation of ethylmorphine, so that oxidative drug metabolism was probably also decreased in vivo in the cordotomized … Advisors/Committee Members: Larson, Robert E. (advisor), Fink, Gregory B. (committee member).

Subjects/Keywords: Rats

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APA (6^th Edition):

Koeferl, M. T. (1972). Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45738

Chicago Manual of Style (16^th Edition):

Koeferl, Michael Tallyn. “Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats.” 1972. Doctoral Dissertation, Oregon State University. Accessed October 22, 2018. http://hdl.handle.net/1957/45738.

MLA Handbook (7^th Edition):

Koeferl, Michael Tallyn. “Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats.” 1972. Web. 22 Oct 2018.

Vancouver:

Koeferl MT. Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats. [Internet] [Doctoral dissertation]. Oregon State University; 1972. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/1957/45738.

Council of Science Editors:

Koeferl MT. Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats. [Doctoral Dissertation]. Oregon State University; 1972. Available from: http://hdl.handle.net/1957/45738

Oregon State University

11. Lu, Irene. The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats.

Degree: PhD, Pharmacology and Toxicology, 1972, Oregon State University

URL: http://hdl.handle.net/1957/45924

► Preliminary toxicity studies of BCNU in rats revealed that significant prolongations of pentobarbital hypnosis were associated with all doses employed. Investigations were undertaken to determine… (more)

▼ Preliminary toxicity studies of BCNU in rats revealed that significant prolongations of pentobarbital hypnosis were associated with all doses employed. Investigations were undertaken to determine the underlying mechanism responsible for this observed effect. Studies on the in vitro metabolism of pentobarbital by hepatic microsomes of BCNU-treated animals demonstrated that significant impairment of enzyme activities had occurred as early as 7 days following a single dose. The effect was dose-related, and progressed through 21 days post treatment. Kinetic changes in the microsomal enzymes were characterized by a greatly diminished maximum velocity and an unaltered Michaelis constant. Repeated administrations of phenobarbital for 5 days following a single dose of BCNU greatly increased the pentobarbital metabolizing activity given on the seventh post-BCNU day. These results suggested that the observed prolongation of pentobarbital sleeptime in rats following BCNU treatment could be largely explained by impaired metabolism of the pentobarbital in these animals. The effect of BCNU on microsomal enzyme systems was not limited to pentobarbital oxidation. Inhibition of ethylmorphine Ndemethylation, hexobarbital oxidation, aniline hydroxylation and p- nitrobenzoic acid reduction were evident at 13 days after a single dose of 30 mg/kg of BCNU. The extent of inhibition was equivalent in all systems considered. Therefore, it was apparent that BCNU affected both oxidation and reduction reactions. Moreover, metabolism of both type I and type II compounds as determined by their characteristic spectral properties upon binding to microsomes was impaired. The general depression of microsomal enzyme activities resulting from BCNU treatment could not be accounted for by deficiencies of cofactors nor actual loss of the enzymes; however, the effect was found to be closely related to significant reductions of the microsomal hemoprotein, cytochrome P-450, which is known to play an important role in the final phase of the electron transport chain. Decreases of cytochrome P-450 levels in BCNU-treated rats were again dose-related and prolonged, as observed through 21 days post treatment. Interestingly, cytochrome b₅, the second of the two hemoproteins in liver microsomes, and total microsomal protein were not significantly affected by BCNU. Parallel temporal effects on pentobarbital metabolizing activity and levels of cytochrome P-450 gave further evidence that the major effect of BCNU on the hepatic drug metabolizing systems was specifically upon cytochrome P-450. A seven-day starvation in rats resulted in severe impairment of oxidation of pentobarbital by liver microsomes. Alterations of enzyme kinetics, levels of cytochrome P-450, cytochrome b₅ and total protein were equivalent to rats at 7 days following a single dose of BCNU (30 mg/kg). Despite the fact that BCNU-treated animals exhibited tremendous decreases in food consumption and severe weight losses, the effect of BCNU on drug metabolism was… Advisors/Committee Members: Larson, Robert E. (advisor).

Subjects/Keywords: Rats

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APA (6^th Edition):

Lu, I. (1972). The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45924

Chicago Manual of Style (16^th Edition):

Lu, Irene. “The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats.” 1972. Doctoral Dissertation, Oregon State University. Accessed October 22, 2018. http://hdl.handle.net/1957/45924.

MLA Handbook (7^th Edition):

Lu, Irene. “The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats.” 1972. Web. 22 Oct 2018.

Vancouver:

Lu I. The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats. [Internet] [Doctoral dissertation]. Oregon State University; 1972. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/1957/45924.

Council of Science Editors:

Lu I. The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats. [Doctoral Dissertation]. Oregon State University; 1972. Available from: http://hdl.handle.net/1957/45924

Texas Tech University

12. Simmons, Horace Orion. The deposition of ingested stannous flouride in the femur of the albino rat.

Degree: 1959, Texas Tech University

URL: http://hdl.handle.net/2346/19966

Subjects/Keywords: Rats

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APA (6^th Edition):

Simmons, H. O. (1959). The deposition of ingested stannous flouride in the femur of the albino rat. (Masters Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/19966

Chicago Manual of Style (16^th Edition):

Simmons, Horace Orion. “The deposition of ingested stannous flouride in the femur of the albino rat.” 1959. Masters Thesis, Texas Tech University. Accessed October 22, 2018. http://hdl.handle.net/2346/19966.

MLA Handbook (7^th Edition):

Simmons, Horace Orion. “The deposition of ingested stannous flouride in the femur of the albino rat.” 1959. Web. 22 Oct 2018.

Vancouver:

Simmons HO. The deposition of ingested stannous flouride in the femur of the albino rat. [Internet] [Masters thesis]. Texas Tech University; 1959. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/2346/19966.

Council of Science Editors:

Simmons HO. The deposition of ingested stannous flouride in the femur of the albino rat. [Masters Thesis]. Texas Tech University; 1959. Available from: http://hdl.handle.net/2346/19966

Texas Tech University

13. Simmons, Horace Orion. The deposition of ingested stannous flouride in the femur of the albino rat.

Degree: 1959, Texas Tech University

URL: http://hdl.handle.net/2346/11435

Subjects/Keywords: Rats

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APA (6^th Edition):

Simmons, H. O. (1959). The deposition of ingested stannous flouride in the femur of the albino rat. (Masters Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/11435

Chicago Manual of Style (16^th Edition):

Simmons, Horace Orion. “The deposition of ingested stannous flouride in the femur of the albino rat.” 1959. Masters Thesis, Texas Tech University. Accessed October 22, 2018. http://hdl.handle.net/2346/11435.

MLA Handbook (7^th Edition):

Simmons, Horace Orion. “The deposition of ingested stannous flouride in the femur of the albino rat.” 1959. Web. 22 Oct 2018.

Vancouver:

Simmons HO. The deposition of ingested stannous flouride in the femur of the albino rat. [Internet] [Masters thesis]. Texas Tech University; 1959. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/2346/11435.

Council of Science Editors:

Simmons HO. The deposition of ingested stannous flouride in the femur of the albino rat. [Masters Thesis]. Texas Tech University; 1959. Available from: http://hdl.handle.net/2346/11435

14. Moon, Harold Leon. Body weight loss and peptic ulcers in the albino rat.

Degree: Psychology, 1958, Texas Tech University

URL: http://hdl.handle.net/2346/19644

Subjects/Keywords: Rats

…obtained experimentally in rats by Selye (10,11) and by Sawrey and his associates… …considered the employment of a psychological conflict situation; he restrained his rats by binding… …their legs to their bodies, causing them to struggle for freedom. Sawrey placed rats under… …formation in rats is desirable. Criticism of the Methods Employing Rats The results obtained by… …to ulcer formation in rats. In Selye's aniiials the s t x u g f ^ : l e against…

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APA (6^th Edition):

Moon, H. L. (1958). Body weight loss and peptic ulcers in the albino rat. (Masters Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/19644

Chicago Manual of Style (16^th Edition):

Moon, Harold Leon. “Body weight loss and peptic ulcers in the albino rat.” 1958. Masters Thesis, Texas Tech University. Accessed October 22, 2018. http://hdl.handle.net/2346/19644.

MLA Handbook (7^th Edition):

Moon, Harold Leon. “Body weight loss and peptic ulcers in the albino rat.” 1958. Web. 22 Oct 2018.

Vancouver:

Moon HL. Body weight loss and peptic ulcers in the albino rat. [Internet] [Masters thesis]. Texas Tech University; 1958. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/2346/19644.

Council of Science Editors:

Moon HL. Body weight loss and peptic ulcers in the albino rat. [Masters Thesis]. Texas Tech University; 1958. Available from: http://hdl.handle.net/2346/19644

University of British Columbia

15. Tomlinson, Raymond Valentine. The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat .

Degree: 1956, University of British Columbia

URL: http://hdl.handle.net/2429/40556

► 1,3-N¹⁵ -,2-C¹⁴ -adenine was synthesized and administered to rats by intraperitoneal injection. The compound was incorporated as both adenine and guanine into the visceral nucleic… (more)

Subjects/Keywords: Rats

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APA (6^th Edition):

Tomlinson, R. V. (1956). The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat . (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/40556

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tomlinson, Raymond Valentine. “The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat .” 1956. Thesis, University of British Columbia. Accessed October 22, 2018. http://hdl.handle.net/2429/40556.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tomlinson, Raymond Valentine. “The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat .” 1956. Web. 22 Oct 2018.

Vancouver:

Tomlinson RV. The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat . [Internet] [Thesis]. University of British Columbia; 1956. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/2429/40556.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tomlinson RV. The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat . [Thesis]. University of British Columbia; 1956. Available from: http://hdl.handle.net/2429/40556

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Montana

16. Ramsey, A. Frank. Embryology of microphthalmus in Rattus norvegicus albinus the albino rat.

Degree: MA, 1940, University of Montana

URL: https://scholarworks.umt.edu/etd/6537

Subjects/Keywords: Rats.

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APA (6^th Edition):

Ramsey, A. F. (1940). Embryology of microphthalmus in Rattus norvegicus albinus the albino rat. (Masters Thesis). University of Montana. Retrieved from https://scholarworks.umt.edu/etd/6537

Chicago Manual of Style (16^th Edition):

Ramsey, A Frank. “Embryology of microphthalmus in Rattus norvegicus albinus the albino rat.” 1940. Masters Thesis, University of Montana. Accessed October 22, 2018. https://scholarworks.umt.edu/etd/6537.

MLA Handbook (7^th Edition):

Ramsey, A Frank. “Embryology of microphthalmus in Rattus norvegicus albinus the albino rat.” 1940. Web. 22 Oct 2018.

Vancouver:

Ramsey AF. Embryology of microphthalmus in Rattus norvegicus albinus the albino rat. [Internet] [Masters thesis]. University of Montana; 1940. [cited 2018 Oct 22]. Available from: https://scholarworks.umt.edu/etd/6537.

Council of Science Editors:

Ramsey AF. Embryology of microphthalmus in Rattus norvegicus albinus the albino rat. [Masters Thesis]. University of Montana; 1940. Available from: https://scholarworks.umt.edu/etd/6537

Michigan State University

17. Erwin, William Grady. A genetic study of dental caries in the albino rat (rattus norvegicus).

Degree: PhD, 1940, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:4868

Subjects/Keywords: Rats

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APA (6^th Edition):

Erwin, W. G. (1940). A genetic study of dental caries in the albino rat (rattus norvegicus). (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:4868

Chicago Manual of Style (16^th Edition):

Erwin, William Grady. “A genetic study of dental caries in the albino rat (rattus norvegicus).” 1940. Doctoral Dissertation, Michigan State University. Accessed October 22, 2018. http://etd.lib.msu.edu/islandora/object/etd:4868.

MLA Handbook (7^th Edition):

Erwin, William Grady. “A genetic study of dental caries in the albino rat (rattus norvegicus).” 1940. Web. 22 Oct 2018.

Vancouver:

Erwin WG. A genetic study of dental caries in the albino rat (rattus norvegicus). [Internet] [Doctoral dissertation]. Michigan State University; 1940. [cited 2018 Oct 22]. Available from: http://etd.lib.msu.edu/islandora/object/etd:4868.

Council of Science Editors:

Erwin WG. A genetic study of dental caries in the albino rat (rattus norvegicus). [Doctoral Dissertation]. Michigan State University; 1940. Available from: http://etd.lib.msu.edu/islandora/object/etd:4868

Nelson Mandela Metropolitan University

18. Wickens, Nicolas John. Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract.

Degree: Faculty of Health Sciences, 2012, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/4742

► In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using… (more)

▼ In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using histopathologic, morphometric and transmission electron microscopic analysis. The histopathologic changes in the duodenum, heart, kidney, liver, lung, pancreas and spleen of male Wistar rats were evaluated. Fifty-four rats were randomly divided into four groups: Group 1 – Normal diet control (ND control), n=7, Group 2 – Normal diet + plant extract (ND + p), n=9, Group 3 – High fat diet control (HFD control), n=19Group 4 – High fat diet + p (HFD + p), n=19In the high fat group male Wistar rats were fed ±55 g/day of a specialised high fat diet over a 46 week period to induce obesity and an insulin resistant state. The treatment groups (groups 2 and 4) received a dose concentration of a tea extract of the S. frutescens plant in their drinking water daily. This study showed that the consumption of S. frutescens significantly reduces weight gain in male Wistar rats on a chronic high fat diet (p≤0.001 vs. HFD control group). S. frutescens appears to propagate periportal and centrilobular glycogen storage in rat hepatocytes in the experimental groups as exemplified by a significantly (p≤0.0001 vs. control groups) increased incidences of Periodic Acid Schiff (PAS) positive staining S. frutescens also reduced intracellular lipid accumulation as made evident by the significantly lower incidence of epicardial adipose tissue (EAT), hepatic steatosis and pancreatic interstitial fat. Obesity was associated with increased fibrotic lesions such as myocardial perivascular fibrosis, centrilobular hepatic fibrosis and pancreatic periductal fibrosis. Obesity associated hypertension contributed to the widespread and significant increase in the average lesion severity of arterial congestion in all organs in the HFD control group. Pulmonary infection was equally prevalent in all rats. Despite the complex histopathology in all groups, differences in the control groups, such as, the presence of a conservative polymorphonuclear leukocyte (PMNL) infiltration, substantial intra-alveolar oedema and focal arterial wall hypertrophy in the control groups was highly suggestive of Sendai viral infection. However histopathologic evidence, in the treatment groups, suggested chronic recurrent viral infection with superimposed Mycoplasma pulmonis (M. pulmonis) bacterial infection. The impact of advanced suppurative pulmonary infection was widespread and exemplified by increased lesion incidences of spontaneous murine progressive cardiomyopathy (MCP) and spontaneous chronic progressive nephropathy (CPN) among others. In conclusion S. frutescens administered for 46 weeks to male Wistar rats significantly lowered intracellular lipid accumulation and obesity associated myocardial, renal, hepatobiliary, pulmonary and pancreatic histopathology. Moreover, duodenal, cardiovascular, hepatobiliary, pulmonary, renal, pancreatic and splenic tissue did not show histopathologic evidence of direct plant…

Subjects/Keywords: Rats – Physiology; Rats as laboratory animals

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APA (6^th Edition):

Wickens, N. J. (2012). Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/4742

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wickens, Nicolas John. “Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract.” 2012. Thesis, Nelson Mandela Metropolitan University. Accessed October 22, 2018. http://hdl.handle.net/10948/4742.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wickens, Nicolas John. “Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract.” 2012. Web. 22 Oct 2018.

Vancouver:

Wickens NJ. Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2012. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/10948/4742.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wickens NJ. Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract. [Thesis]. Nelson Mandela Metropolitan University; 2012. Available from: http://hdl.handle.net/10948/4742

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

19. Chen, Haiyan. Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats.

Degree: MS;, Exercise & Sport Science;, 2009, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335

► The purpose of the current study was to nvestigate the effects of developmental massage therapy (DMT) during early postnatal life on growth, body composition, and… (more)

▼ The purpose of the current study was to nvestigate the effects of developmental massage therapy (DMT) during early postnatal life on growth, body composition, and skeletal development in juvenile and young adult rats. Twenty-four rat pups received a daily session of DMT (10 minutes/day) from D6 to D10 of postnatal life and were compared to matched controls (CTL, n=24). Body composition, soft tissue lean mass, fat mass, bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured by peripheral dual energy X-ray absorptiometry (pDXA); bone strength (Peak Load) and intrinsic stiffness on femur shaft were tested by three-point bending (MTS); cortical and cancellous bone histomorphometric measurements were performed on the tibia shaft and metaphysis. Food and water intake were monitored and did not differ among groups between weaning (D21) and D60. Body weight, body length and soft tissue lean mass at D21 were significantly greater in the DMT cohort; at D60 soft tissue lean mass was still greater in DMT groups but no differences were detected in body weight and body length. Moderate to strong correlations were found between body weight and soft tissue lean mass and measured bone outcome variables. BMD by DXA was significantly higher in D21 DMT rats and BA was only greater in D60 DMT males. Femur diameter and length were significantly greater in D60 DMT males. Bone strength and the endosteal percent mineral surface were significantly increased in D60 DMT females compared to CTL. In addition, DMT treatment improved the cancellous bone mineral surface, mineral apposition rate and bone formation rate on the trabecular bone surface area in D21 female rats. Treatment and sex interactions were found for BMC and BA at D60. In summary, DMT during early postnatal life elicited anabolic effects on muscle-bone relationships in juvenile (D21) and young adult (D60) rats. These findings were confirmed histologically by increased percent mineral surface and mineral apposition rates. It is speculated that the positive skeletal outcomes were, in part, due to a modulation of stress by DMT resulting in an improved balance of the neuroendocrine system and regulation of the muscle-bone unit. The absence of biochemical markers as well as body composition and bone studies in older animals suggest a need for future studies to verify whether early life DMT has a prolonged positive impact on lifelong skeletal health.

Subjects/Keywords: Massage therapy; Rats

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APA (6^th Edition):

Chen, H. (2009). Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335

Chicago Manual of Style (16^th Edition):

Chen, Haiyan. “Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats.” 2009. Masters Thesis, University of Utah. Accessed October 22, 2018. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335.

MLA Handbook (7^th Edition):

Chen, Haiyan. “Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats.” 2009. Web. 22 Oct 2018.

Vancouver:

Chen H. Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats. [Internet] [Masters thesis]. University of Utah; 2009. [cited 2018 Oct 22]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335.

Council of Science Editors:

Chen H. Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats. [Masters Thesis]. University of Utah; 2009. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335

University of Hawaii

20. Philleo, William Wallace. The effect of steroids on RNA synthesis in various tissues of the rat.

Degree: PhD, 2009, University of Hawaii

URL: http://hdl.handle.net/10125/11476

►

Typescript.

Bibliography: leaves 136-144.

xii, 144 l

Single doses of aldosterone were administered to normal rats, and the effect of RNA synthesis was studied. The… (more)

▼

Typescript.

Bibliography: leaves 136-144.

xii, 144 l

Single doses of aldosterone were administered to normal rats, and the effect of RNA synthesis was studied. The maximal stimulation of the incorporation of l4c-ATP into RNA by nuclei isolated from rat kidneys was observed 30 minutes after an intravenous injection of aldosterone. Thereafter, the RNA synthesis decreased to a level less than that of the control, reaching a minimum at 2.5 hours. The return to control level was followed by further oscillations in RNA synthesis. Likewise, in isolated brain nuclei, an oscillation in RNA synthesis was observed following an intravenous injection of aldosterone. The effect of single injections of aldosterone, cortisol, deoxycorticosterone acetate, testosterone or progesterone was studied on RNA synthesis by isolated rat spleen nuclei. It was found that the l4C-ATP incorporation was initially inhibited following the injection of aldosterone, cortisol or deoxycorticosterone acetate. The initial response to an injection of testosterone or progesterone was a stimulation in the spleen RNA synthesis. The response to the administration of aldosterone was similar to that of cortisol. Subsequent to the initial inhibition, a stimulation followed by a return to the level of the control, was observed and secondary inhibitions were found. RNA synthesis in the thymus was initially inhibited following the administration of aldosterone. RNA synthesis was studied in the nuclei isolated from the kidney and spleen of adrenalectomized or hypophysectomized rats injected with aldosterone. Oscillations were observed in the RNA synthesis of both tissues of the endocrinectomized rats. It was concluded that the oscillations in RNA synthesis were not a function of some form of homeostatic control involving the pituitary and adrenal glands. Aldactone (SC 9420) was found to modify the RNA synthesis of nuclei isolated from the kidney, spleen and thymus of intact, adrenalectomized or hypophysectomized rats. Again, oscillations in RNA synthesis were observed, however there was the suggestion that the adrenals or the pituitary might be involved in the response as observed in the kidney and the thymus. Experiments were carried out in which both aldosterone and Aldactone were injected, and their action on RNA synthesis was observed in the kidney, spleen and thymus. The results indicated that these two steroids alter RNA synthesis independently from each other. Analysis of the RNA synthesized in vitro by the isolated nuclei of the kidney and spleen indicated that only a single species of RNA was made. This 5 s RNA was identical to that species of RNA present in nuclei, prior to incubation for the incorporation of l4C-ATP.

Subjects/Keywords: Steroids; RNA; Rats

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APA (6^th Edition):

Philleo, W. W. (2009). The effect of steroids on RNA synthesis in various tissues of the rat. (Doctoral Dissertation). University of Hawaii. Retrieved from http://hdl.handle.net/10125/11476

Chicago Manual of Style (16^th Edition):

Philleo, William Wallace. “The effect of steroids on RNA synthesis in various tissues of the rat.” 2009. Doctoral Dissertation, University of Hawaii. Accessed October 22, 2018. http://hdl.handle.net/10125/11476.

MLA Handbook (7^th Edition):

Philleo, William Wallace. “The effect of steroids on RNA synthesis in various tissues of the rat.” 2009. Web. 22 Oct 2018.

Vancouver:

Philleo WW. The effect of steroids on RNA synthesis in various tissues of the rat. [Internet] [Doctoral dissertation]. University of Hawaii; 2009. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/10125/11476.

Council of Science Editors:

Philleo WW. The effect of steroids on RNA synthesis in various tissues of the rat. [Doctoral Dissertation]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/11476

University of Hawaii

21. Guthrie, Helen Andrews. Undernutrition, brain composition and behavior in rats.

Degree: 2009, University of Hawaii

URL: http://hdl.handle.net/10125/11313

►

Typescript.

Bibliography: leaves [89]-97.

vii, 106 l illus., tables

The purpose of the present study was two-fold. The first was to assess the effect of… (more)

▼

Typescript.

Bibliography: leaves [89]-97.

vii, 106 l illus., tables

The purpose of the present study was two-fold. The first was to assess the effect of varying periods of undernutrition from birth through nine weeks of age, followed by nutritional rehabilitation with an adequate diet, on growth, brain size and composition and learning capacity in mature male rats; the second was to determine if there is a critical period in the development of the brain after which it is refractory to nutritional rehabilitation. Undernutrition was achieved by feeding litters of 16 pups on a dam fed an 8 per cent casein diet and feeding a diet of 3 per cent casein at weaning. Control rats were fed in litters of eight by a dam on the same 18 per cent casein diet to which the pups were weaned at 21 days. Undernourished pups were changed to an adequate diet at three, five, seven or nine weeks of age. Rats were maintained in an environment controlled for temperature, light and stimulation. Beginning at 16 weeks the mature rats were given a series of behavioral tests – exploratory activity in a novel situation, emotionality, activity level, neuromuscular coordination and learning in an avoidance learning situation. At 19 weeks the animals were killed by ether anesthesia. The weighed brains were analyzed for DNA, RNA, cholesterol and phospholipid phosphorus content. No differences were found in learning capacity as assessed by avoidance conditioning, or in neuromuscular coordination or emotionality. The undernourished animals were significantly (p < .01) more active than the adequately nourished controls whereas the larger, well nourished animals reared on their hind legs more frequently in an exploratory situation. Data on brain composition showed that the animals undernourished during suckling had smaller brains, with fewer cells as measured by DNA content (p < .01) than those adequately nourished from birth. An adequate diet introduced at weaning did not stimulate cell proliferation. Those animals deprived five or more weeks had significantly less total brain cholesterol than those rehabilitated after deprivation during sucking only (p < .01). This confirms other findings and shows that the critical period for cholesterol deposition indicative of myelin formation is in the first five weeks of life. There were no differences in the phospholipid phosphorus content of brains of deprived and adequately nourished rats. RNA values did not differ significantly among groups but were correlated r = 0.90 with DNA values. RNA: DNA ratios were approximately 1.0 for all groups. On the basis of weight there were no differences in the chemical composition of the brains of deprived and well nourished control rats. The animals with smaller brains learned to avoid shock in a shuttle box equally as well as well-nourished controls with larger brains of similar chemical composition and were significantly (p < .01) more active.

Subjects/Keywords: Rats; Nutrition; Brain

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APA (6^th Edition):

Guthrie, H. A. (2009). Undernutrition, brain composition and behavior in rats. (Thesis). University of Hawaii. Retrieved from http://hdl.handle.net/10125/11313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guthrie, Helen Andrews. “Undernutrition, brain composition and behavior in rats.” 2009. Thesis, University of Hawaii. Accessed October 22, 2018. http://hdl.handle.net/10125/11313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guthrie, Helen Andrews. “Undernutrition, brain composition and behavior in rats.” 2009. Web. 22 Oct 2018.

Vancouver:

Guthrie HA. Undernutrition, brain composition and behavior in rats. [Internet] [Thesis]. University of Hawaii; 2009. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/10125/11313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guthrie HA. Undernutrition, brain composition and behavior in rats. [Thesis]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/11313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brock University

22. Mulligan, Matthew J. Glucose dynamics in rat skeletal muscle : recovery from osmotic stress .

Degree: Applied Health Sciences Program, 2008, Brock University

URL: http://hdl.handle.net/10464/1605

► The purpose of this study was to examine cell glucose kinetics in rat skeletal muscle during iso-osmotic recovery from hyper- and hypo-osmotic stress. Rat EDL… (more)

Subjects/Keywords: Blood sugar.; Rats

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APA (6^th Edition):

Mulligan, M. J. (2008). Glucose dynamics in rat skeletal muscle : recovery from osmotic stress . (Thesis). Brock University. Retrieved from http://hdl.handle.net/10464/1605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mulligan, Matthew J. “Glucose dynamics in rat skeletal muscle : recovery from osmotic stress .” 2008. Thesis, Brock University. Accessed October 22, 2018. http://hdl.handle.net/10464/1605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mulligan, Matthew J. “Glucose dynamics in rat skeletal muscle : recovery from osmotic stress .” 2008. Web. 22 Oct 2018.

Vancouver:

Mulligan MJ. Glucose dynamics in rat skeletal muscle : recovery from osmotic stress . [Internet] [Thesis]. Brock University; 2008. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/10464/1605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mulligan MJ. Glucose dynamics in rat skeletal muscle : recovery from osmotic stress . [Thesis]. Brock University; 2008. Available from: http://hdl.handle.net/10464/1605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

23. [No author]. Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.

Degree: Pharmacy and pharmacology, 2008, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/1171

► Background: Evidence from our laboratories indicates that triterpene constituents of Syzygium cordatum (Hochst.) [Myrtaceae] crude leaf extracts can be used to treat diabetes mellitus. For… (more)

▼ Background: Evidence from our laboratories indicates that triterpene constituents of Syzygium cordatum (Hochst.) [Myrtaceae] crude leaf extracts can be used to treat diabetes mellitus. For the plant derived triterpenes to have further potential in diabetes management, they should, however, additionally alleviate or prevent some of the complications of diabetes mellitus such as impaired kidney function and cardiovascular disorders. Accordingly, this study was designed to isolate the triterpene, oleanolic acid (OA) from S. cordatum leaves and evaluate its effects on blood glucose, renal function and blood pressure in streptozotocin (STZ)-induced diabetic rats. OA was studied because it is the major constituent of many African plant species used in traditional medicine. Materials and Methods S. cordatum crude leaf ethyl acetate solubles (EAS) were obtained after defatting the leaves with hexane followed by dichloromethane before maceration with ethyl acetate. Preliminary experiments indicated that EAS contained triterpenes with hypoglycaemic properties. Solvent extraction and fractionation of EAS yielded mixtures of oleanolic acid/ursolic acid (OA/UA) and methyl maslinate/methyl corosolate. Recrystallisation of the OA/UA mixture using ethanol yielded OA, the structure of which was confirmed by NMR spectroscopy ('H & 13C). Oral glucose tolerance test (OGTT) responses to various doses of OA (40, 80 and 120 mg/kg) were monitored in separate groups of non-diabetic and STZ-induced diabetic rats given a glucose load (0.86 g/kg, p.o.) after an 18-h fast. Rats treated with deionized water (3 ml/kg p.o.), or standard drugs, (insulin, 200 Hg/kg, s.c; metformin, 500 mg/kg, p.o. and glibenclamide, 500 f^g/kg, p.o.) acted as untreated and treated positive controls, respectively. To investigate the possible interaction between OA and standard drugs in lowering blood glucose, OGTT responses were studied in separate groups of animals simultaneously treated with OA at either 40 or 80 mg/kg and insulin (100 or 200 ug/kg, s.c), metformin, (250 or 500 mg/kg, p.o.) or glibenclamide (250 or 500 mg/kg, p.o.). Blood glucose was monitored at 15-min intervals for the first hour, and hourly thereafter for 3 h. Plasma insulin concentrations were measured in separate parallel groups of rats prepared as for OGTT studies to examine whether there was an association between OA treatment and pancreatic insulin secretion. Acute effects of OA on kidney function and mean arterial blood pressure (MAP) were investigated in anaesthetized rats challenged with hypotonic saline after a 3'/2-h equilibration for 4 h consisting of 1 h control, 1XA h treatment and 1 Vi h recovery periods. OA was added to the infusate during the treatment period. Short-term effects of OA were studied in individually-caged rats treated twice daily with OA (80 mg/kg, p.o.) for 5 weeks. Results OA decreased blood glucose concentrations of both non-diabetic and diabetic rats, as did some standard drugs except glibenclamide which did not exhibit any effects in STZ-induced diabetic…

Subjects/Keywords: Renal effects – Rats.; Streptozotocin – Rats.; Diabetes – Rats.; Pharmacy and pharmacology.

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APA (6^th Edition):

author], [. (2008). Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/1171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats. ” 2008. Thesis, University of KwaZulu-Natal. Accessed October 22, 2018. http://hdl.handle.net/10413/1171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats. ” 2008. Web. 22 Oct 2018.

Vancouver:

author] [. Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats. [Internet] [Thesis]. University of KwaZulu-Natal; 2008. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/10413/1171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats. [Thesis]. University of KwaZulu-Natal; 2008. Available from: http://hdl.handle.net/10413/1171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McGill University

24. Davies, Richard F. Some neurochemical and physiological factors controlling free feeding patterns in the rat.

Degree: PhD, Department of Psychology, 1976, McGill University

URL: http://digitool.library.mcgill.ca/thesisfile69186.pdf

Subjects/Keywords: Rats – Food; Rats – Physiology; Rats – Behavior

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APA (6^th Edition):

Davies, R. F. (1976). Some neurochemical and physiological factors controlling free feeding patterns in the rat. (Doctoral Dissertation). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile69186.pdf

Chicago Manual of Style (16^th Edition):

Davies, Richard F. “Some neurochemical and physiological factors controlling free feeding patterns in the rat.” 1976. Doctoral Dissertation, McGill University. Accessed October 22, 2018. http://digitool.library.mcgill.ca/thesisfile69186.pdf.

MLA Handbook (7^th Edition):

Davies, Richard F. “Some neurochemical and physiological factors controlling free feeding patterns in the rat.” 1976. Web. 22 Oct 2018.

Vancouver:

Davies RF. Some neurochemical and physiological factors controlling free feeding patterns in the rat. [Internet] [Doctoral dissertation]. McGill University; 1976. [cited 2018 Oct 22]. Available from: http://digitool.library.mcgill.ca/thesisfile69186.pdf.

Council of Science Editors:

Davies RF. Some neurochemical and physiological factors controlling free feeding patterns in the rat. [Doctoral Dissertation]. McGill University; 1976. Available from: http://digitool.library.mcgill.ca/thesisfile69186.pdf

The Ohio State University

25. Howard, Richard Lee. An exploration of the relative importance of motivation and interference in the motivational control of retrograde amnesia in rats.

Degree: PhD, Graduate School, 1975, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705

Subjects/Keywords: Psychology; Rats

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APA (6^th Edition):

Howard, R. L. (1975). An exploration of the relative importance of motivation and interference in the motivational control of retrograde amnesia in rats. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705

Chicago Manual of Style (16^th Edition):

Howard, Richard Lee. “An exploration of the relative importance of motivation and interference in the motivational control of retrograde amnesia in rats.” 1975. Doctoral Dissertation, The Ohio State University. Accessed October 22, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705.

MLA Handbook (7^th Edition):

Howard, Richard Lee. “An exploration of the relative importance of motivation and interference in the motivational control of retrograde amnesia in rats.” 1975. Web. 22 Oct 2018.

Vancouver:

Howard RL. An exploration of the relative importance of motivation and interference in the motivational control of retrograde amnesia in rats. [Internet] [Doctoral dissertation]. The Ohio State University; 1975. [cited 2018 Oct 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705.

Council of Science Editors:

Howard RL. An exploration of the relative importance of motivation and interference in the motivational control of retrograde amnesia in rats. [Doctoral Dissertation]. The Ohio State University; 1975. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705

University of Utah

26. White, Harold Steve. In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;.

Degree: PhD, Pharmacology & Toxicology;, 1984, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667

► Various parameters of anion and cation transport were measured in the cerebral cortex of neonatal (3 days old) and adult rats following acute and chronic… (more)

▼ Various parameters of anion and cation transport were measured in the cerebral cortex of neonatal (3 days old) and adult rats following acute and chronic treatment with PHT. Acutely, phenytoin (PHT) significantly inhibited the enzyme Na+, K+-ATPase in both neonatal and adult rats. This effect was accompanied by a significant increase in cerebral cortical sodium (Na+) content and a decrease in potassium (K+) content only in neonatal animals. Chronic treatment (bid and qid for 7 days) of adult rats with PHT significantly reduced the Na+ content without affecting the whole homogenate Na+, K+-ATPase activity. The activity of this enzyme was markedly increased in the myelin- (glial product) and slightly decreased in the synaptosomal- (neuronal) fractions following chronic (qid for 7 days) PHT treatment. These results suggest that PHT differentially affects the two forms (neuronal and glial) of the enzyme Na+, K+-ATPase. The possible relevance of this hypothesis in relationship to the anticonvulsant and excitatory properties of PHT is discussed. Chronic (bid and qid for 7 days) PHT treatment increased both DNA content and activity of the glial marker enzyme carbonic anhydrase. Activity of the mitochondrial enzyme HCO3-C1-ATPase was also increased following chronic PHT treatment. These two enzymes are intimately involved in the regulation of HCO3[-]-C1- transport across glial cell and mitochondrial membranes, and these results suggest that PHT is able to beneficially effect glial regulatory processes. The ability to enhance glial regulation of extracellular fluid anions and cations provides new and important insights into the mechanism of the anticonvulsant action of PHT. The activity of enzymes involved in anion and cation transport, the concentration of intracellular potassium (K+i), and the trans-membrane potential (Em) was determined following acute and chronic exposure of primary astroglial cultures to micro-molar concentrations of phenytoin (PHT). Na+, K+-ATPase activity of homogenates of cultured glial cells was determined in the presence of increasing K+ concentration (1-20 mM). Acutely, PHT had little effect on the K+-activation pattern of Na+, K+-ATPase. In contrast, the percent of Na+, K+-ATPase activated by elevating the K+ concentration was dose-dependently increased by chronic PHT treatment. This effect was accompanied by a marked increase in K+i and a significant membrane hyper polarization. The acute effect of PHT on the Em was biphasic, characterized by membrane hyper polarization at concentrations of 1 x 10[-6] to 1 x 10[-5] M. At concentrations between 1 x 10[-5] M and 1 x 10[-4] M, the Em progressively returned to control values. These results suggest that glial cells acutely and chronically treated with therapeutic concentrations of PHT have an enhanced capacity to control elevated extracellular potassium. Return of the Em to control values at PHT concentrations greater than 1 x 10[-5] M suggest that these cells are less able to regulate extracellular potassium. These data can partially explain the…

Subjects/Keywords: Physiology; Rats

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APA (6^th Edition):

White, H. S. (1984). In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667

Chicago Manual of Style (16^th Edition):

White, Harold Steve. “In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;.” 1984. Doctoral Dissertation, University of Utah. Accessed October 22, 2018. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667.

MLA Handbook (7^th Edition):

White, Harold Steve. “In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;.” 1984. Web. 22 Oct 2018.

Vancouver:

White HS. In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;. [Internet] [Doctoral dissertation]. University of Utah; 1984. [cited 2018 Oct 22]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667.

Council of Science Editors:

White HS. In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;. [Doctoral Dissertation]. University of Utah; 1984. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667

University of Utah

27. Noordewier, Byron. Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;.

Degree: PhD, Pharmacology & Toxicology;, 1976, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429

► The effect of pretreatment with penicillin on para-aminohippurate (PAH) transport by kidney of the immature rat was evaluated in vivo. After 3 days of penicillin… (more)

Subjects/Keywords: Rats; Physiology

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APA (6^th Edition):

Noordewier, B. (1976). Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429

Chicago Manual of Style (16^th Edition):

Noordewier, Byron. “Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;.” 1976. Doctoral Dissertation, University of Utah. Accessed October 22, 2018. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429.

MLA Handbook (7^th Edition):

Noordewier, Byron. “Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;.” 1976. Web. 22 Oct 2018.

Vancouver:

Noordewier B. Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;. [Internet] [Doctoral dissertation]. University of Utah; 1976. [cited 2018 Oct 22]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429.

Council of Science Editors:

Noordewier B. Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;. [Doctoral Dissertation]. University of Utah; 1976. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429

Michigan State University

28. Leffler, Edna Estella. The comparative growth response of rats to the proteins of casein, yeast, sunflower meal, wheat germ and corn germ.

Degree: MS, 1944, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:14176

Subjects/Keywords: Proteins; Rats

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APA (6^th Edition):

Leffler, E. E. (1944). The comparative growth response of rats to the proteins of casein, yeast, sunflower meal, wheat germ and corn germ. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:14176

Chicago Manual of Style (16^th Edition):

Leffler, Edna Estella. “The comparative growth response of rats to the proteins of casein, yeast, sunflower meal, wheat germ and corn germ.” 1944. Masters Thesis, Michigan State University. Accessed October 22, 2018. http://etd.lib.msu.edu/islandora/object/etd:14176.

MLA Handbook (7^th Edition):

Leffler, Edna Estella. “The comparative growth response of rats to the proteins of casein, yeast, sunflower meal, wheat germ and corn germ.” 1944. Web. 22 Oct 2018.

Vancouver:

Leffler EE. The comparative growth response of rats to the proteins of casein, yeast, sunflower meal, wheat germ and corn germ. [Internet] [Masters thesis]. Michigan State University; 1944. [cited 2018 Oct 22]. Available from: http://etd.lib.msu.edu/islandora/object/etd:14176.

Council of Science Editors:

Leffler EE. The comparative growth response of rats to the proteins of casein, yeast, sunflower meal, wheat germ and corn germ. [Masters Thesis]. Michigan State University; 1944. Available from: http://etd.lib.msu.edu/islandora/object/etd:14176

Boston University

29. Johnson, Carson Carl, Jr. Running wheel activity in the white rat as a function of activity restriction and food deprivation.

Degree: PhD, Psychology, 1963, Boston University

URL: http://hdl.handle.net/2144/29159

► The current study was conducted to determine whether restriction acts as a drive when suitable controls for the hunger drive are provided. The employment of… (more)

Subjects/Keywords: Nutrition; Rats

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APA (6^th Edition):

Johnson, Carson Carl, J. (1963). Running wheel activity in the white rat as a function of activity restriction and food deprivation. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/29159

Chicago Manual of Style (16^th Edition):

Johnson, Carson Carl, Jr. “Running wheel activity in the white rat as a function of activity restriction and food deprivation.” 1963. Doctoral Dissertation, Boston University. Accessed October 22, 2018. http://hdl.handle.net/2144/29159.

MLA Handbook (7^th Edition):

Johnson, Carson Carl, Jr. “Running wheel activity in the white rat as a function of activity restriction and food deprivation.” 1963. Web. 22 Oct 2018.

Vancouver:

Johnson, Carson Carl J. Running wheel activity in the white rat as a function of activity restriction and food deprivation. [Internet] [Doctoral dissertation]. Boston University; 1963. [cited 2018 Oct 22]. Available from: http://hdl.handle.net/2144/29159.

Council of Science Editors:

Johnson, Carson Carl J. Running wheel activity in the white rat as a function of activity restriction and food deprivation. [Doctoral Dissertation]. Boston University; 1963. Available from: http://hdl.handle.net/2144/29159

University of Utah

30. Goodnight, James Edgar. Determination of factors responsible for long-term survival of rat heart allografts;.

Degree: PhD, Pathology;, 1976, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299

► Long-term survival of whole organ allografts can be obtained without the use of chronic nonspecific immunosuppression. Administration of anti-donor antibody or donor antigen to the… (more)

▼ Long-term survival of whole organ allografts can be obtained without the use of chronic nonspecific immunosuppression. Administration of anti-donor antibody or donor antigen to the host or short-term treatment of the host with anti-lymphocytic serum (ALS) is some of the methods most commonly used to induce this phenomenon. A steady state is produced in the host in which the allograft appears safe from rejection even though the host retains a capacity to respond to donor antigens and is able to reject allografts from other donors in normal fashion. The mechanisms underlying this phenomenon have not been completely defined. In this study, long-term survival of Ag-B compatible rat heart allografts was obtained by short-term treatment of the recipients with ALS. Graft survival apparently was based on a specific change in the hosts rather than on persistent nonspecific effects of ALS. The hosts were not fully tolerant in that they were able to reject secondary skin allografts from the heart donor strain, through in a delayed fashion. The long-surviving heart allografts retained their immunogenicity as they were rejected when retransplanted to new hosts. The passive transfer of serum from long-term heart graft acceptors to new host receiving fresh allografts delayed rejection by several days. This effect was seen only with the serum from long-term acceptors suggesting that serum-blocking factors were involved in long-term survival of the heart. allografts. However, the ability of aboptively transferred lymphoid cell to break tolerance to a heart allograft residing in a classically tolerant host was tested.. In contrast to normal lymphoid cells, cells from the long-term acceptors were unable to break tolerance, suggesting that a specific cellular tolerance had been induced in this cell population. Moreover, serum from the long-term acceptors failed to block the breakage of tolerance by normal lymphoid cells. The overriding factor in obtaining long-term heart allograft survival is a predisposition in a particular host-recipient combination towards an enhancement response. Inbred rat strains, Fischer (Fi) and Lewis (Le), share the serological Ag-B1 allele and react very weakly in a mixed lymphocyte culture (MLC). In spite of this apparent identity an Ag-B, these strains differ markedly in their immune responses to histocompatibility antigens from an Ag-B disparate third strain, Marshall (Ma) (Ag-B6). Fi recipients allowed Ma heart grafts an extended survival where as Le recipients rejected them rapidly. Fi and Ma showed a weak response to MLC in contrast to a strong response for Le and Ma. Fi produced antisera in response to Ma which had a relatively high titer of antibody but low cytotoxic activity. Fi responded to another strain, Buffalo (Buf) (also Ag-B6), in a similar fashion. Fi apparently can produce a strong allogeneic response as it was able to reject LBN (Ag-B1/3) heart grafts rapidly. The low response of Fi and Ma probably was not due to shared antigens between the two strains because Ma heart grafts underwent rapid…

Subjects/Keywords: Heart; Rats

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APA (6^th Edition):

Goodnight, J. E. (1976). Determination of factors responsible for long-term survival of rat heart allografts;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299

Chicago Manual of Style (16^th Edition):

Goodnight, James Edgar. “Determination of factors responsible for long-term survival of rat heart allografts;.” 1976. Doctoral Dissertation, University of Utah. Accessed October 22, 2018. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299.

MLA Handbook (7^th Edition):

Goodnight, James Edgar. “Determination of factors responsible for long-term survival of rat heart allografts;.” 1976. Web. 22 Oct 2018.

Vancouver:

Goodnight JE. Determination of factors responsible for long-term survival of rat heart allografts;. [Internet] [Doctoral dissertation]. University of Utah; 1976. [cited 2018 Oct 22]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299.

Council of Science Editors:

Goodnight JE. Determination of factors responsible for long-term survival of rat heart allografts;. [Doctoral Dissertation]. University of Utah; 1976. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299

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