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University of Georgia
1.
Scherer, Isabell Juliane.
The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system.
Degree: MS, Foods and Nutrition, 2009, University of Georgia
URL: http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms 
► Rats exposed to repeated restraint (RR) lose weight and do not return to the weight of nonstressed controls (CTRL). This study tested the effect of…
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▼ Rats exposed to repeated restraint (RR) lose weight and do not return to the weight of nonstressed controls (CTRL). This study tested the effect of corticosterone (cort) on sustained weight loss by subjecting intact, adrenalectomized (ADX) and ADX with cort replacement (ADX CORT)
rats to RR. RR ADX CORT
rats had the same initial and sustained weight loss as
RR intact
rats. CTRL ADX CORT and RR ADX
rats lost half as much weight and maintained the weight loss for less time than RR intact. Thus both stress-induced cort and an undefined aspect of RR are required for sustained weight loss. In a second set of
rats, PVN CRF mRNA expression was increased in ADX and RR
rats compared with CTRL intact
rats. Cort did not inhibit expression in ADX
rats. This suggests that cort contributes to initial and sustained weight loss in RR
rats independent of PVN CRF mRNA.
Advisors/Committee Members: Ruth Harris.
Subjects/Keywords: rats
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APA (6th Edition):
Scherer, I. J. (2009). The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms
Chicago Manual of Style (16th Edition):
Scherer, Isabell Juliane. “The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system.” 2009. Masters Thesis, University of Georgia. Accessed August 18, 2019.
http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms.
MLA Handbook (7th Edition):
Scherer, Isabell Juliane. “The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system.” 2009. Web. 18 Aug 2019.
Vancouver:
Scherer IJ. The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system. [Internet] [Masters thesis]. University of Georgia; 2009. [cited 2019 Aug 18].
Available from: http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms.
Council of Science Editors:
Scherer IJ. The effect of corticosterone on stress-induced weight loss and stress related neuropeptide mRNA expression in the limbic system. [Masters Thesis]. University of Georgia; 2009. Available from: http://purl.galileo.usg.edu/uga_etd/scherer_isabell_j_200905_ms
2.
Po, Chrystelle.
Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat.
Degree: Docteur es, Chimie, 2009, Evry-Val d'Essonne
URL: http://www.theses.fr/2009EVRY0002
► Le but de cette étude était de caractériser par IRM et SRM in vivo le développement à court et moyen terme des atteintes cérébrales consécutives…
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▼ Le but de cette étude était de caractériser par IRM et SRM in vivo le développement à court et moyen terme des atteintes cérébrales consécutives à une ischémie expérimentale transitoire focale chez le rat nouveau né (P7). Les résultats obtenus ont montré que l’IRM à court terme permettait le suivi de l’extension des aires atteintes pendant l’ischémie et la reperfusion et que ce suivi avait un caractère prédictif en ce qui concerne le devenir futur de ces tissus. Le suivi a moyen terme a permis de mettre en évidence le développement d’une cicatrice gliale dans les aires atteintes, par imagerie pondérée T2, et les réorganisations des réseaux de fibres cérébrales, par imagerie du tenseur de diffusion dans cette cicatrice et dans des aires adjacentes homolatérales. Les protocoles d’IRM développés seront donc des outils performants pour l’évaluation de traitements thérapeutiques ayant pour cible ces deux processus.
The aim of this study was to characterize by in vivo MRI and MRS the short term and middle term developments of cerebral injuries following an experimental transient focal ischemia in the newborn rat (P7). The results show the efficiency of MRI to monitor the short term extent of the injured areas during ischemia and reperfusion and to predict the extent of the middle term extent of brain damage. The middle term monitoring has shown the development of a glial scar in the injured areas, by T2 weighted imaging, and the remodeling of the cerebral fiber networks, by Diffusion Tensor Imaging both in the glial scar and in ipsilateral adjacent areas. The monitoring of cerebral ischemia by these imaging methods will be thus a useful tool to evaluate the efficiency of therapeutic treatments directed toward these two processes.
Advisors/Committee Members: Méric, Philippe (thesis director).
Subjects/Keywords: Rats
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APA (6th Edition):
Po, C. (2009). Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat. (Doctoral Dissertation). Evry-Val d'Essonne. Retrieved from http://www.theses.fr/2009EVRY0002
Chicago Manual of Style (16th Edition):
Po, Chrystelle. “Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat.” 2009. Doctoral Dissertation, Evry-Val d'Essonne. Accessed August 18, 2019.
http://www.theses.fr/2009EVRY0002.
MLA Handbook (7th Edition):
Po, Chrystelle. “Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat.” 2009. Web. 18 Aug 2019.
Vancouver:
Po C. Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat. [Internet] [Doctoral dissertation]. Evry-Val d'Essonne; 2009. [cited 2019 Aug 18].
Available from: http://www.theses.fr/2009EVRY0002.
Council of Science Editors:
Po C. Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né : Study by MRI at high field of the transient cerebral ischemia in newborn rat. [Doctoral Dissertation]. Evry-Val d'Essonne; 2009. Available from: http://www.theses.fr/2009EVRY0002
University of Hawaii
3.
Fial, Ronald Augustine.
Hippocampal structure and function in the albino rat.
Degree: PhD, 2009, University of Hawaii
URL: http://hdl.handle.net/10125/11911
► Typescript.
Bibliography: leaves [74]-79.
viii, 79 l illus., charts, tables
Theories concerning the function of the hippocampus in behavior have treated this structure as being…
(more)
▼ Typescript.
Bibliography: leaves [74]-79.
viii, 79 l illus., charts, tables
Theories concerning the function of the hippocampus in behavior have treated this structure as being homogenous in function. Inconsistencies in prior research have sometimes been attributed to differences in procedures or to extra-hippocampal damage resulting from the manipulation. While these factors have been shown to be potent variables, several writers have suggested that lesion location within the hippocampus is important and that smaller lesions are to be preferred to the generally large ones used in most earlier work. Recent work involving the organization of afferent and efferent pathways of the hippocampus has shown these to be well organized in terms of the various "fields" of the structure as distinguished by early anatomists. In the present experiment 14 control operated (HC), 14 hippocampally lesioned (BE), 16 dorsal fornix lesioned (DF) and 16 lateral fimbria lesioned (LF) albino rats were tested in a series of five behavioral tasks in order to assess the relative behavioral effects of gross hippocampal lesions and lesions of the hippocampal efferent pathways. No group differences were found in open field activity levels, or in number of approaches to novel ob.1ects placed in an open field. In an orienting shift task with subjects under 23-hour water deprivation, HE, LF and DF groups had shorter initial latencies to drink than HC subjects, and the HE group made fewer orientations to light stimuli but not to tone stimuli. In a passive avoidance task the HE and LF groups made more errors than the HC. group. In addition the HE group also made more errors than the LF and DF groups. HE and LF groups fought less than the DF and HC groups in a reflexive fighting task. The LF group also demonstrated shorter boxing-posture maintenance relative to the HC and Dr groups at the end of the reflexive fighting session. All groups were similar to each other in a shock threshold rating situation, but the HE group had a lower jump threshold than the HC group. The effects of the gross lesions were similar to those obtained in previous studies. Response perseveration, internal inhibition, and stimulus gating interpretations of hippocampal function were discussed and it was concluded that the gross lesion effects were best explained on the basis of an involvement of anxiety-defensive immobility mechanisms. The pattern of results for the behavioral tasks changed markedly as a function of the efferent path lesion location. Unitary explanations were rejected, and it was concluded that anatomical differences in hippocampal projections are accompanied by separation of function. Two multi-functional interpretations were offered to account for the differences observed.
Subjects/Keywords: Rats – Anatomy; Rats – Physiology
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APA (6th Edition):
Fial, R. A. (2009). Hippocampal structure and function in the albino rat. (Doctoral Dissertation). University of Hawaii. Retrieved from http://hdl.handle.net/10125/11911
Chicago Manual of Style (16th Edition):
Fial, Ronald Augustine. “Hippocampal structure and function in the albino rat.” 2009. Doctoral Dissertation, University of Hawaii. Accessed August 18, 2019.
http://hdl.handle.net/10125/11911.
MLA Handbook (7th Edition):
Fial, Ronald Augustine. “Hippocampal structure and function in the albino rat.” 2009. Web. 18 Aug 2019.
Vancouver:
Fial RA. Hippocampal structure and function in the albino rat. [Internet] [Doctoral dissertation]. University of Hawaii; 2009. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/10125/11911.
Council of Science Editors:
Fial RA. Hippocampal structure and function in the albino rat. [Doctoral Dissertation]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/11911
Oregon State University
4.
Tinsley, Joel Ray.
The influence of vegetable fibers on mineral balance in the rat.
Degree: MS, Food Science and Technology, 1979, Oregon State University
URL: http://hdl.handle.net/1957/27195
► Dietary fiber has been suggested as interfering with mineral utilization. The influence of broccoli florets and wastes, cauliflower heads and wastes, wheat bran and Metamucil…
(more)
▼ Dietary fiber has been suggested as interfering with
mineral utilization. The influence of broccoli florets and
wastes, cauliflower heads and wastes, wheat bran and Metamucil
on mineral uptake by the rat was determined using
balance studies. All results were compared to control
animals fed diets containing 10% hydrolyzed cellulose.
Utilization of Ca, Mg, Cu, Zn and Fe were determined to be
62, 33, 23, 42, and 52% respectively for control animals.
The uptake of Mg, Zn and Fe were significantly reduced to 12,
16 and 18% respectively from broccoli florets. Broccoli
wastes decreased absorption of Zn to 14% and created a negative
iron balance. Cauliflower heads improved Zn assimilation
to 61%. Cauliflower wastes depressed Ca absorption to
26% and caused Mg balance to be negative. Wheat bran improved
utilization of Ca and Zn to 88 and 54% respectively.
Metamucil increased uptake of Ca to 88% and Mg to 53%. Copper
balance was unaffected by any test diet. To better understand results of balance trials, the bioavailability of
Fe from some sources was measured. The relative biological
values (RBV) of endogenous Fe in broccoli, cauliflower,
Brussel sprouts and wheat bran were determined to be 93, 88,
83, 98% respectively. These values were obtained using
rats
fed control diets containing 5% hydrolyzed cellulose and
ferrous sulfate (RBV = 100). The efficiency - true bioavailability
of utilizing dietary Fe is approximately one-half
of the RBV. These values agree well with apparent uptake
of iron by animals in the balance trials for all diets
except broccoli. This exception may be due to differences
in the amount and source of broccoli fed. High dietary
levels of broccoli florets and wastes appear to interfere
with utilization of Fe and Zn. Cauliflower wastes depress
absorption of Ca and Mg. With the exceptions noted, dietary
fiber from plant sources does not appear to decrease the
utilization of minerals by the rat. The nature of mineral
complexes in plants may be more important in defining the
degree of its absorption.
Advisors/Committee Members: Gordon, Dennis T. (advisor).
Subjects/Keywords: Rats
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APA (6th Edition):
Tinsley, J. R. (1979). The influence of vegetable fibers on mineral balance in the rat. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/27195
Chicago Manual of Style (16th Edition):
Tinsley, Joel Ray. “The influence of vegetable fibers on mineral balance in the rat.” 1979. Masters Thesis, Oregon State University. Accessed August 18, 2019.
http://hdl.handle.net/1957/27195.
MLA Handbook (7th Edition):
Tinsley, Joel Ray. “The influence of vegetable fibers on mineral balance in the rat.” 1979. Web. 18 Aug 2019.
Vancouver:
Tinsley JR. The influence of vegetable fibers on mineral balance in the rat. [Internet] [Masters thesis]. Oregon State University; 1979. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/1957/27195.
Council of Science Editors:
Tinsley JR. The influence of vegetable fibers on mineral balance in the rat. [Masters Thesis]. Oregon State University; 1979. Available from: http://hdl.handle.net/1957/27195
Montana Tech
5.
Ramsey, A. Frank.
Embryology of microphthalmus in Rattus norvegicus albinus the albino rat.
Degree: MA, 1940, Montana Tech
URL: https://scholarworks.umt.edu/etd/6537
Subjects/Keywords: Rats.
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APA (6th Edition):
Ramsey, A. F. (1940). Embryology of microphthalmus in Rattus norvegicus albinus the albino rat. (Masters Thesis). Montana Tech. Retrieved from https://scholarworks.umt.edu/etd/6537
Chicago Manual of Style (16th Edition):
Ramsey, A Frank. “Embryology of microphthalmus in Rattus norvegicus albinus the albino rat.” 1940. Masters Thesis, Montana Tech. Accessed August 18, 2019.
https://scholarworks.umt.edu/etd/6537.
MLA Handbook (7th Edition):
Ramsey, A Frank. “Embryology of microphthalmus in Rattus norvegicus albinus the albino rat.” 1940. Web. 18 Aug 2019.
Vancouver:
Ramsey AF. Embryology of microphthalmus in Rattus norvegicus albinus the albino rat. [Internet] [Masters thesis]. Montana Tech; 1940. [cited 2019 Aug 18].
Available from: https://scholarworks.umt.edu/etd/6537.
Council of Science Editors:
Ramsey AF. Embryology of microphthalmus in Rattus norvegicus albinus the albino rat. [Masters Thesis]. Montana Tech; 1940. Available from: https://scholarworks.umt.edu/etd/6537
Oregon State University
6.
Shumake, James Michael.
Physiology of the corpus luteum of the rat.
Degree: MS, Zoology, 1966, Oregon State University
URL: http://hdl.handle.net/1957/48002
► Rat luteal cells from functional and non-functional corpora lutea (corpora lutea rendered non-functional by hypophysectomy) were preserved for light and electron microscopy in Bouin's and…
(more)
▼ Rat luteal cells from functional and non-functional
corpora lutea (corpora lutea rendered non-functional by
hypophysectomy) were preserved for light and electron
microscopy in Bouin's and glutaraldehyde-osmium fixation
respectively. Material for electron microscopy was dehydrated
with ethanol, embedded in Araldite and stained
with lead hydroxide or uranyl acetate-lead citrate. Examination
of functional and three day non-functional luteal
cells by the electron microscope revealed no detectable
differences in ultrastructure. The appearance of
dense bodies demarcated the one week non-functional luteal
cells which also contained a more dilated endoplasmic
reticulum and more spherical mitochondria. Luteal cells,
non-functional for two weeks, were similar to one week
non-functional cells except for more exaggerated structural
differences. Dilation of the endoplasmic reticulum
may have been due to poor fixation. Luteal cells which
were non-functional for one month showed marked changes
from functional luteal cells: i.e. mitochondria of low
density and a sparse endoplasmic reticulum; dense bodies,
and ribosomes were still evident. From these results,
functional luteal cells cannot be distinguished from early
non-functional cells by electron microscopy. Distinctions
can be noted only after a period of three to seven days
following cessation of function. Several hypotheses are
presented in relation to the mechanism of action of luteotropic
hormone.
Advisors/Committee Members: Hisaw, Frederick L. (advisor).
Subjects/Keywords: Rats
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APA (6th Edition):
Shumake, J. M. (1966). Physiology of the corpus luteum of the rat. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/48002
Chicago Manual of Style (16th Edition):
Shumake, James Michael. “Physiology of the corpus luteum of the rat.” 1966. Masters Thesis, Oregon State University. Accessed August 18, 2019.
http://hdl.handle.net/1957/48002.
MLA Handbook (7th Edition):
Shumake, James Michael. “Physiology of the corpus luteum of the rat.” 1966. Web. 18 Aug 2019.
Vancouver:
Shumake JM. Physiology of the corpus luteum of the rat. [Internet] [Masters thesis]. Oregon State University; 1966. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/1957/48002.
Council of Science Editors:
Shumake JM. Physiology of the corpus luteum of the rat. [Masters Thesis]. Oregon State University; 1966. Available from: http://hdl.handle.net/1957/48002
Oregon State University
7.
Lock, Albert.
The vagal inhibitory reflex in the rat stomach.
Degree: PhD, Pharmacology, 1971, Oregon State University
URL: http://hdl.handle.net/1957/45700
► Electrical stimulation of the vagus nerves produces an excitatory contraction response in the isolated rat stomach. This contraction response was abolished by atropine to unmask…
(more)
▼ Electrical stimulation of the vagus nerves produces an excitatory
contraction response in the isolated rat stomach. This contraction
response was abolished by atropine to unmask the vagal inhibitory
response (VIR) elicited during low frequency vagal stimulation.
Babring and Gershon (1967), after working on guinea-pigs and mice,
hypothesized that both serotonin (5-HT) and acetylcholine (ACh) are
neurotransmitters acting on the same ganglion cell in the vagal inhibitory
pathway. This hypothesis for the role of 5-HT was tested in the
rat after the VIR of the isolated stomach was characterized. The
hypothesis was tested with 5-HT depletory, parachlorophenylalanine
(PCPA) and reserpine, and a ganglionic blocking agent, hexamethonium
(C₆). If the hypothesized role for 5-HT is true, the depletion of
5-HT from stomach tissues should influence the VIR. Furthermore,
if both 5-HT and ACh are neurotransmitters acting on the same
ganglion cell in the vagal inhibitory pathway, the addition of C₆
should only block the action of ACh but not the actions of 5-HT in
the ganglia. Thus, vagal stimulation after the addition of C₆, in
the presence of atropine, should still produce a VIR due to the action
of 5-HT.
The VIR was present in all groups of
rats tested and remained
unchanged even though large amounts of 5-HT were depleted from the
stomach tissues. The possibility still exists that the small amounts
of 5-HT remaining after treatment with PCPA and reserpine could
be sufficient to maintain the vagal inhibitory pathway. However, the
VIR of the rat was completely abolished by C₆. These results indicate
that serotonin is not involved either pre- or postganglionically
in the vagal inhibitory pathway of the rat stomach.
Stimulation of the vagus nerves of the in situ rat stomach elicited a
gastric relaxation response in contrast to the contraction response
observed with the isolated stomach. This in situ relaxation response
was elicited by stimulation of the intact vagi as well as by peripheral
vagal stimulation. The in situ relaxation response was characterized
and an effort was made to determine the relationship between the
in situ relaxation response and the VIR. Some experimental conditions
which may influence the in situ relaxation response were investigated.
The influence of age and sex, lowered body temperature,
starvation and partial evisceration by removal of the intestines, on
the in situ relaxation response were examined. None of the above conditions appeared to affect this response except the partial evisceration
of the animal. The in situ relaxation response was abolished
following the removal of the intestines and succeeding stimulation
of the vagi elicited only gastric contractions. Subsequent treatment
with guanethidine, reserpine and 6-hydroxydopamine (6- OHDA), all
resulted in the reversal of the in situ relaxation response into a
contraction response to vagal stimulation. Atropine abolished the
contraction response to reveal the VIR. The evidence indicates
that the in situ…
Advisors/Committee Members: Weber, Lavern J. (advisor).
Subjects/Keywords: Rats
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APA (6th Edition):
Lock, A. (1971). The vagal inhibitory reflex in the rat stomach. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45700
Chicago Manual of Style (16th Edition):
Lock, Albert. “The vagal inhibitory reflex in the rat stomach.” 1971. Doctoral Dissertation, Oregon State University. Accessed August 18, 2019.
http://hdl.handle.net/1957/45700.
MLA Handbook (7th Edition):
Lock, Albert. “The vagal inhibitory reflex in the rat stomach.” 1971. Web. 18 Aug 2019.
Vancouver:
Lock A. The vagal inhibitory reflex in the rat stomach. [Internet] [Doctoral dissertation]. Oregon State University; 1971. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/1957/45700.
Council of Science Editors:
Lock A. The vagal inhibitory reflex in the rat stomach. [Doctoral Dissertation]. Oregon State University; 1971. Available from: http://hdl.handle.net/1957/45700
Oregon State University
8.
Koeferl, Michael Tallyn.
Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats.
Degree: PhD, Pharmacology and Toxicology, 1972, Oregon State University
URL: http://hdl.handle.net/1957/45738
► There has been no toxicologic proof that the long-term, low-level exposure of man to chlorophenothane (DDT) is linked with an increased susceptibility to toxicity or…
(more)
▼ There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of
rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the hepatotoxic response to CC1₄ is similar among
mammalian species, it was believed man's response could also be
altered by prior exposure to DDT. Chronic pretreatment of
rats with
DDT more closely duplicates man's exposure situation, which is
mainly dietary. Therefore, this present investigation was undertaken
to quantify the DDT-CCI₄ hepatotoxic interaction in
rats from the
standpoint of a chronic dietary exposure to DDT.
Chronic and acute pretreatments with DDT were compared for
their relative effects on acute CC1₄ hepatotoxicity. Subgroups of
rats
fed DDT at concentrations of 6-65 ppm for three weeks and 65 ppm
for 24 weeks attained body burdens of DDT and its metabolites ranging
from 6.1 to 30.6 ppm, compared to 0 ppm (no detectable) for controls.
In the acute study, subgroups of
rats were dosed with 35-150 mg/kg
DDT by gavage 24 hours prior to CC1₄
exposure. Doses of CC1₄
ranging from 0.125 to 1.0 mi./kg were administered by gavage. All
pretreatments with DDT, chronic or acute, resulted in a potentiated
elevation of serum transaminase (SGPT and SGOT) activities following
treatment with CC1₄. The degree of potentiation was dose-related to
CCI₄
and to the total DDT body burden. In a temporal study, the
onset of the potentiated response was noted six hours after CC1₄. All
of the above-mentioned results were confirmed by histopathology.
Plasma BSP disappearance, dose-response and temporal studies
were conducted in control and DDT-fed rat groups, utilizing the BSP
test as an index of hepatic functional impairment, CC1₄-induced BSP
retention was greatly potentiated by prior dietary exposure to DDT.
This potentiation effect was obscured at a dose of 2.0 ml/kg CC1₄, due
to the severe hepatic damage produced by this dose of CCI₄
given
alone. The onset and development of the potentiated hepatic dysfunction
paralleled that of the parenchymal cell destruction.
The potentiated CC1₄-induced increases in SGOT activity and
centrilobularly-oriented coagulative necrosis in the DDT-fed animals
were prevented by spinal cord transection at the level of the seventh cervical vertebra. Chronic DDT pretreatment did not enhance CC1₄
uptake into the blood or livers of intact
rats, and this was ruled out
as a possible mechanism for the potentiation effect. Cord-sectioning
did enhance tissue CC1₄
uptake, yet these animals were protected
against CC1₄-induced central necrosis. Neither cord-sectioning nor
the resultant hypothermia reduced the microsomal cytochrome P-450
content in control or DDT-fed
rats. Hypothermia depressed the in
vitro N-demethylation of ethylmorphine, so that oxidative drug metabolism
was probably also decreased in vivo in the cordotomized
…
Advisors/Committee Members: Larson, Robert E. (advisor), Fink, Gregory B. (committee member).
Subjects/Keywords: Rats
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APA ·
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Manager
APA (6th Edition):
Koeferl, M. T. (1972). Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45738
Chicago Manual of Style (16th Edition):
Koeferl, Michael Tallyn. “Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats.” 1972. Doctoral Dissertation, Oregon State University. Accessed August 18, 2019.
http://hdl.handle.net/1957/45738.
MLA Handbook (7th Edition):
Koeferl, Michael Tallyn. “Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats.” 1972. Web. 18 Aug 2019.
Vancouver:
Koeferl MT. Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats. [Internet] [Doctoral dissertation]. Oregon State University; 1972. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/1957/45738.
Council of Science Editors:
Koeferl MT. Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats. [Doctoral Dissertation]. Oregon State University; 1972. Available from: http://hdl.handle.net/1957/45738
Oregon State University
9.
Lu, Irene.
The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats.
Degree: PhD, Pharmacology and Toxicology, 1972, Oregon State University
URL: http://hdl.handle.net/1957/45924
► Preliminary toxicity studies of BCNU in rats revealed that significant prolongations of pentobarbital hypnosis were associated with all doses employed. Investigations were undertaken to determine…
(more)
▼ Preliminary toxicity studies of BCNU in
rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant impairment
of enzyme activities had occurred as early as 7 days following a
single dose. The effect was dose-related, and progressed through
21 days post treatment. Kinetic changes in the microsomal enzymes
were characterized by a greatly diminished maximum velocity and
an unaltered Michaelis constant. Repeated administrations of phenobarbital
for 5 days following a single dose of BCNU greatly increased
the pentobarbital metabolizing activity given on the seventh post-BCNU
day. These results suggested that the observed prolongation of pentobarbital
sleeptime in
rats following BCNU treatment could be largely
explained by impaired metabolism of the pentobarbital in these animals.
The effect of BCNU on microsomal enzyme systems was not
limited to pentobarbital oxidation. Inhibition of ethylmorphine Ndemethylation,
hexobarbital oxidation, aniline hydroxylation and p-
nitrobenzoic acid reduction were evident at 13 days after a single
dose of 30 mg/kg of BCNU. The extent of inhibition was equivalent
in all systems considered. Therefore, it was apparent that BCNU
affected both oxidation and reduction reactions. Moreover, metabolism
of both type I and type II compounds as determined by their
characteristic spectral properties upon binding to microsomes was
impaired.
The general depression of microsomal enzyme activities resulting
from BCNU treatment could not be accounted for by deficiencies
of cofactors nor actual loss of the enzymes; however, the effect
was found to be closely related to significant reductions of the microsomal
hemoprotein, cytochrome P-450, which is known to play an
important role in the final phase of the electron transport chain.
Decreases of cytochrome P-450 levels in BCNU-treated
rats were
again dose-related and prolonged, as observed through 21 days post
treatment. Interestingly, cytochrome b₅, the second of the two hemoproteins in liver microsomes, and total microsomal protein
were not significantly affected by BCNU. Parallel temporal effects
on pentobarbital metabolizing activity and levels of cytochrome P-450
gave further evidence that the major effect of BCNU on the hepatic
drug metabolizing systems was specifically upon cytochrome P-450.
A seven-day starvation in
rats resulted in severe impairment
of oxidation of pentobarbital by liver microsomes. Alterations of
enzyme kinetics, levels of cytochrome P-450, cytochrome b₅ and total protein were equivalent to
rats at 7 days following a single dose
of BCNU (30 mg/kg). Despite the fact that BCNU-treated animals
exhibited tremendous decreases in food consumption and severe weight
losses, the effect of BCNU on drug metabolism was…
Advisors/Committee Members: Larson, Robert E. (advisor).
Subjects/Keywords: Rats
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APA (6th Edition):
Lu, I. (1972). The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45924
Chicago Manual of Style (16th Edition):
Lu, Irene. “The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats.” 1972. Doctoral Dissertation, Oregon State University. Accessed August 18, 2019.
http://hdl.handle.net/1957/45924.
MLA Handbook (7th Edition):
Lu, Irene. “The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats.” 1972. Web. 18 Aug 2019.
Vancouver:
Lu I. The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats. [Internet] [Doctoral dissertation]. Oregon State University; 1972. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/1957/45924.
Council of Science Editors:
Lu I. The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats. [Doctoral Dissertation]. Oregon State University; 1972. Available from: http://hdl.handle.net/1957/45924
University of British Columbia
10.
Tomlinson, Raymond Valentine.
The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat
.
Degree: 1956, University of British Columbia
URL: http://hdl.handle.net/2429/40556
► 1,3-N¹⁵ -,2-C¹⁴ -adenine was synthesized and administered to rats by intraperitoneal injection. The compound was incorporated as both adenine and guanine into the visceral nucleic…
(more)
▼ 1,3-N¹⁵ -,2-C¹⁴ -adenine was synthesized and administered to rats by intraperitoneal injection. The compound was incorporated as both adenine and guanine into the visceral nucleic acids. Comparison of the C¹⁴/N¹⁵ ratios found in the adenine and guanine isolated from the visceral nucleic acids with that in the injected adenine indicated that for both compounds there had been a loss of C¹⁴ . The decrease in the C¹⁴/N¹⁵ ratio of the polynucleotide guanine was much greater than that in the polynucleotide adenine. The inference drawn from this marked difference was that on at least one pathway for the conversion of adenine to guanine the purine nucleus does not remain intact. The labile 2-C¹⁴ was found as C¹⁴ O₂ in the animals' expired air. Evidence that part of the C¹⁴ O₂ resulted from purine interconversion was afforded by examining the allantoin excreted in the animals’ urine. This compound had a C¹⁴/N¹⁵ ratio consistent with the source from which it was derived, the nucleic acid purine. The deficit of C¹⁴ , apparent from the C¹⁴/N¹⁵ ratio, in this excretory product for 47% of the C¹⁴ O₂ expired by the animals.
Subjects/Keywords: Rats
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APA (6th Edition):
Tomlinson, R. V. (1956). The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat
. (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/40556
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tomlinson, Raymond Valentine. “The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat
.” 1956. Thesis, University of British Columbia. Accessed August 18, 2019.
http://hdl.handle.net/2429/40556.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tomlinson, Raymond Valentine. “The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat
.” 1956. Web. 18 Aug 2019.
Vancouver:
Tomlinson RV. The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat
. [Internet] [Thesis]. University of British Columbia; 1956. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/2429/40556.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tomlinson RV. The conversion of 1,3-N15-,2-c14-adenine to polynucleotide adenine and guanine in the adult male rat
. [Thesis]. University of British Columbia; 1956. Available from: http://hdl.handle.net/2429/40556
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Michigan State University
11.
Bendixsen, Kay Reed.
A comparison of two strains of rats and the crosses between them under two environmental conditions.
Degree: PhD, Department of Animal Husbandry, 1965, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:16575
Subjects/Keywords: Rats
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Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
Bendixsen, K. R. (1965). A comparison of two strains of rats and the crosses between them under two environmental conditions. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:16575
Chicago Manual of Style (16th Edition):
Bendixsen, Kay Reed. “A comparison of two strains of rats and the crosses between them under two environmental conditions.” 1965. Doctoral Dissertation, Michigan State University. Accessed August 18, 2019.
http://etd.lib.msu.edu/islandora/object/etd:16575.
MLA Handbook (7th Edition):
Bendixsen, Kay Reed. “A comparison of two strains of rats and the crosses between them under two environmental conditions.” 1965. Web. 18 Aug 2019.
Vancouver:
Bendixsen KR. A comparison of two strains of rats and the crosses between them under two environmental conditions. [Internet] [Doctoral dissertation]. Michigan State University; 1965. [cited 2019 Aug 18].
Available from: http://etd.lib.msu.edu/islandora/object/etd:16575.
Council of Science Editors:
Bendixsen KR. A comparison of two strains of rats and the crosses between them under two environmental conditions. [Doctoral Dissertation]. Michigan State University; 1965. Available from: http://etd.lib.msu.edu/islandora/object/etd:16575
Michigan State University
12.
Barton, Louis Jesse.
Studies on the production of scaliness in rats & the effectiveness of arachidonic acid in eliminating this condition.
Degree: MS, 1940, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:8854
Subjects/Keywords: Rats
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Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Barton, L. J. (1940). Studies on the production of scaliness in rats & the effectiveness of arachidonic acid in eliminating this condition. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:8854
Chicago Manual of Style (16th Edition):
Barton, Louis Jesse. “Studies on the production of scaliness in rats & the effectiveness of arachidonic acid in eliminating this condition.” 1940. Masters Thesis, Michigan State University. Accessed August 18, 2019.
http://etd.lib.msu.edu/islandora/object/etd:8854.
MLA Handbook (7th Edition):
Barton, Louis Jesse. “Studies on the production of scaliness in rats & the effectiveness of arachidonic acid in eliminating this condition.” 1940. Web. 18 Aug 2019.
Vancouver:
Barton LJ. Studies on the production of scaliness in rats & the effectiveness of arachidonic acid in eliminating this condition. [Internet] [Masters thesis]. Michigan State University; 1940. [cited 2019 Aug 18].
Available from: http://etd.lib.msu.edu/islandora/object/etd:8854.
Council of Science Editors:
Barton LJ. Studies on the production of scaliness in rats & the effectiveness of arachidonic acid in eliminating this condition. [Masters Thesis]. Michigan State University; 1940. Available from: http://etd.lib.msu.edu/islandora/object/etd:8854
Michigan State University
13.
Erwin, William Grady.
A genetic study of dental caries in the albino rat (rattus norvegicus).
Degree: PhD, 1940, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:4868
Subjects/Keywords: Rats
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Erwin, W. G. (1940). A genetic study of dental caries in the albino rat (rattus norvegicus). (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:4868
Chicago Manual of Style (16th Edition):
Erwin, William Grady. “A genetic study of dental caries in the albino rat (rattus norvegicus).” 1940. Doctoral Dissertation, Michigan State University. Accessed August 18, 2019.
http://etd.lib.msu.edu/islandora/object/etd:4868.
MLA Handbook (7th Edition):
Erwin, William Grady. “A genetic study of dental caries in the albino rat (rattus norvegicus).” 1940. Web. 18 Aug 2019.
Vancouver:
Erwin WG. A genetic study of dental caries in the albino rat (rattus norvegicus). [Internet] [Doctoral dissertation]. Michigan State University; 1940. [cited 2019 Aug 18].
Available from: http://etd.lib.msu.edu/islandora/object/etd:4868.
Council of Science Editors:
Erwin WG. A genetic study of dental caries in the albino rat (rattus norvegicus). [Doctoral Dissertation]. Michigan State University; 1940. Available from: http://etd.lib.msu.edu/islandora/object/etd:4868
Nelson Mandela Metropolitan University
14.
Wickens, Nicolas John.
Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract.
Degree: Faculty of Health Sciences, 2012, Nelson Mandela Metropolitan University
URL: http://hdl.handle.net/10948/4742
► In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using…
(more)
▼ In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using histopathologic, morphometric and transmission electron microscopic analysis. The histopathologic changes in the duodenum, heart, kidney, liver, lung, pancreas and spleen of male Wistar rats were evaluated. Fifty-four rats were randomly divided into four groups: Group 1 – Normal diet control (ND control), n=7, Group 2 – Normal diet + plant extract (ND + p), n=9, Group 3 – High fat diet control (HFD control), n=19Group 4 – High fat diet + p (HFD + p), n=19In the high fat group male Wistar rats were fed ±55 g/day of a specialised high fat diet over a 46 week period to induce obesity and an insulin resistant state. The treatment groups (groups 2 and 4) received a dose concentration of a tea extract of the S. frutescens plant in their drinking water daily. This study showed that the consumption of S. frutescens significantly reduces weight gain in male Wistar rats on a chronic high fat diet (p≤0.001 vs. HFD control group). S. frutescens appears to propagate periportal and centrilobular glycogen storage in rat hepatocytes in the experimental groups as exemplified by a significantly (p≤0.0001 vs. control groups) increased incidences of Periodic Acid Schiff (PAS) positive staining S. frutescens also reduced intracellular lipid accumulation as made evident by the significantly lower incidence of epicardial adipose tissue (EAT), hepatic steatosis and pancreatic interstitial fat. Obesity was associated with increased fibrotic lesions such as myocardial perivascular fibrosis, centrilobular hepatic fibrosis and pancreatic periductal fibrosis. Obesity associated hypertension contributed to the widespread and significant increase in the average lesion severity of arterial congestion in all organs in the HFD control group. Pulmonary infection was equally prevalent in all rats. Despite the complex histopathology in all groups, differences in the control groups, such as, the presence of a conservative polymorphonuclear leukocyte (PMNL) infiltration, substantial intra-alveolar oedema and focal arterial wall hypertrophy in the control groups was highly suggestive of Sendai viral infection. However histopathologic evidence, in the treatment groups, suggested chronic recurrent viral infection with superimposed Mycoplasma pulmonis (M. pulmonis) bacterial infection. The impact of advanced suppurative pulmonary infection was widespread and exemplified by increased lesion incidences of spontaneous murine progressive cardiomyopathy (MCP) and spontaneous chronic progressive nephropathy (CPN) among others. In conclusion S. frutescens administered for 46 weeks to male Wistar rats significantly lowered intracellular lipid accumulation and obesity associated myocardial, renal, hepatobiliary, pulmonary and pancreatic histopathology. Moreover, duodenal, cardiovascular, hepatobiliary, pulmonary, renal, pancreatic and splenic tissue did not show histopathologic evidence of direct plant…
Subjects/Keywords: Rats – Physiology; Rats as laboratory animals
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APA (6th Edition):
Wickens, N. J. (2012). Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/4742
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wickens, Nicolas John. “Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract.” 2012. Thesis, Nelson Mandela Metropolitan University. Accessed August 18, 2019.
http://hdl.handle.net/10948/4742.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wickens, Nicolas John. “Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract.” 2012. Web. 18 Aug 2019.
Vancouver:
Wickens NJ. Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2012. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/10948/4742.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wickens NJ. Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract. [Thesis]. Nelson Mandela Metropolitan University; 2012. Available from: http://hdl.handle.net/10948/4742
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Utah
15.
Chen, Haiyan.
Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats.
Degree: MS;, Exercise & Sport Science;, 2009, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335
► The purpose of the current study was to nvestigate the effects of developmental massage therapy (DMT) during early postnatal life on growth, body composition, and…
(more)
▼ The purpose of the current study was to nvestigate the effects of developmental massage therapy (DMT) during early postnatal life on growth, body composition, and skeletal development in juvenile and young adult rats. Twenty-four rat pups received a daily session of DMT (10 minutes/day) from D6 to D10 of postnatal life and were compared to matched controls (CTL, n=24). Body composition, soft tissue lean mass, fat mass, bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured by peripheral dual energy X-ray absorptiometry (pDXA); bone strength (Peak Load) and intrinsic stiffness on femur shaft were tested by three-point bending (MTS); cortical and cancellous bone histomorphometric measurements were performed on the tibia shaft and metaphysis. Food and water intake were monitored and did not differ among groups between weaning (D21) and D60. Body weight, body length and soft tissue lean mass at D21 were significantly greater in the DMT cohort; at D60 soft tissue lean mass was still greater in DMT groups but no differences were detected in body weight and body length. Moderate to strong correlations were found between body weight and soft tissue lean mass and measured bone outcome variables. BMD by DXA was significantly higher in D21 DMT rats and BA was only greater in D60 DMT males. Femur diameter and length were significantly greater in D60 DMT males. Bone strength and the endosteal percent mineral surface were significantly increased in D60 DMT females compared to CTL. In addition, DMT treatment improved the cancellous bone mineral surface, mineral apposition rate and bone formation rate on the trabecular bone surface area in D21 female rats. Treatment and sex interactions were found for BMC and BA at D60. In summary, DMT during early postnatal life elicited anabolic effects on muscle-bone relationships in juvenile (D21) and young adult (D60) rats. These findings were confirmed histologically by increased percent mineral surface and mineral apposition rates. It is speculated that the positive skeletal outcomes were, in part, due to a modulation of stress by DMT resulting in an improved balance of the neuroendocrine system and regulation of the muscle-bone unit. The absence of biochemical markers as well as body composition and bone studies in older animals suggest a need for future studies to verify whether early life DMT has a prolonged positive impact on lifelong skeletal health.
Subjects/Keywords: Massage therapy; Rats
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APA (6th Edition):
Chen, H. (2009). Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335
Chicago Manual of Style (16th Edition):
Chen, Haiyan. “Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats.” 2009. Masters Thesis, University of Utah. Accessed August 18, 2019.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335.
MLA Handbook (7th Edition):
Chen, Haiyan. “Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats.” 2009. Web. 18 Aug 2019.
Vancouver:
Chen H. Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats. [Internet] [Masters thesis]. University of Utah; 2009. [cited 2019 Aug 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335.
Council of Science Editors:
Chen H. Developmental massage therapy (DMT) during early postnatal life: effect on bone growth, mineralization, and strength in juvenile and young rats. [Masters Thesis]. University of Utah; 2009. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1952/rec/335
University of Hawaii
16.
Philleo, William Wallace.
The effect of steroids on RNA synthesis in various tissues of the rat.
Degree: PhD, 2009, University of Hawaii
URL: http://hdl.handle.net/10125/11476
► Typescript.
Bibliography: leaves 136-144.
xii, 144 l
Single doses of aldosterone were administered to normal rats, and the effect of RNA synthesis was studied. The…
(more)
▼ Typescript.
Bibliography: leaves 136-144.
xii, 144 l
Single doses of aldosterone were administered to normal rats, and the effect of RNA synthesis was studied. The maximal stimulation of the incorporation of l4c-ATP into RNA by nuclei isolated from rat kidneys was observed 30 minutes after an intravenous injection of aldosterone. Thereafter, the RNA synthesis decreased to a level less than that of the control, reaching a minimum at 2.5 hours. The return to control level was followed by further oscillations in RNA synthesis. Likewise, in isolated brain nuclei, an oscillation in RNA synthesis was observed following an intravenous injection of aldosterone. The effect of single injections of aldosterone, cortisol, deoxycorticosterone acetate, testosterone or progesterone was studied on RNA synthesis by isolated rat spleen nuclei. It was found that the l4C-ATP incorporation was initially inhibited following the injection of aldosterone, cortisol or deoxycorticosterone acetate. The initial response to an injection of testosterone or progesterone was a stimulation in the spleen RNA synthesis. The response to the administration of aldosterone was similar to that of cortisol. Subsequent to the initial inhibition, a stimulation followed by a return to the level of the control, was observed and secondary inhibitions were found. RNA synthesis in the thymus was initially inhibited following the administration of aldosterone. RNA synthesis was studied in the nuclei isolated from the kidney and spleen of adrenalectomized or hypophysectomized rats injected with aldosterone. Oscillations were observed in the RNA synthesis of both tissues of the endocrinectomized rats. It was concluded that the oscillations in RNA synthesis were not a function of some form of homeostatic control involving the pituitary and adrenal glands. Aldactone (SC 9420) was found to modify the RNA synthesis of nuclei isolated from the kidney, spleen and thymus of intact, adrenalectomized or hypophysectomized rats. Again, oscillations in RNA synthesis were observed, however there was the suggestion that the adrenals or the pituitary might be involved in the response as observed in the kidney and the thymus. Experiments were carried out in which both aldosterone and Aldactone were injected, and their action on RNA synthesis was observed in the kidney, spleen and thymus. The results indicated that these two steroids alter RNA synthesis independently from each other. Analysis of the RNA synthesized in vitro by the isolated nuclei of the kidney and spleen indicated that only a single species of RNA was made. This 5 s RNA was identical to that species of RNA present in nuclei, prior to incubation for the incorporation of l4C-ATP.
Subjects/Keywords: Steroids; RNA; Rats
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APA (6th Edition):
Philleo, W. W. (2009). The effect of steroids on RNA synthesis in various tissues of the rat. (Doctoral Dissertation). University of Hawaii. Retrieved from http://hdl.handle.net/10125/11476
Chicago Manual of Style (16th Edition):
Philleo, William Wallace. “The effect of steroids on RNA synthesis in various tissues of the rat.” 2009. Doctoral Dissertation, University of Hawaii. Accessed August 18, 2019.
http://hdl.handle.net/10125/11476.
MLA Handbook (7th Edition):
Philleo, William Wallace. “The effect of steroids on RNA synthesis in various tissues of the rat.” 2009. Web. 18 Aug 2019.
Vancouver:
Philleo WW. The effect of steroids on RNA synthesis in various tissues of the rat. [Internet] [Doctoral dissertation]. University of Hawaii; 2009. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/10125/11476.
Council of Science Editors:
Philleo WW. The effect of steroids on RNA synthesis in various tissues of the rat. [Doctoral Dissertation]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/11476
University of Hawaii
17.
Guthrie, Helen Andrews.
Undernutrition, brain composition and behavior in rats.
Degree: 2009, University of Hawaii
URL: http://hdl.handle.net/10125/11313
► Typescript.
Bibliography: leaves [89]-97.
vii, 106 l illus., tables
The purpose of the present study was two-fold. The first was to assess the effect of…
(more)
▼ Typescript.
Bibliography: leaves [89]-97.
vii, 106 l illus., tables
The purpose of the present study was two-fold. The first was to assess the effect of varying periods of undernutrition from birth through nine weeks of age, followed by nutritional rehabilitation with an adequate diet, on growth, brain size and composition and learning capacity in mature male rats; the second was to determine if there is a critical period in the development of the brain after which it is refractory to nutritional rehabilitation. Undernutrition was achieved by feeding litters of 16 pups on a dam fed an 8 per cent casein diet and feeding a diet of 3 per cent casein at weaning. Control rats were fed in litters of eight by a dam on the same 18 per cent casein diet to which the pups were weaned at 21 days. Undernourished pups were changed to an adequate diet at three, five, seven or nine weeks of age. Rats were maintained in an environment controlled for temperature, light and stimulation. Beginning at 16 weeks the mature rats were given a series of behavioral tests – exploratory activity in a novel situation, emotionality, activity level, neuromuscular coordination and learning in an avoidance learning situation. At 19 weeks the animals were killed by ether anesthesia. The weighed brains were analyzed for DNA, RNA, cholesterol and phospholipid phosphorus content. No differences were found in learning capacity as assessed by avoidance conditioning, or in neuromuscular coordination or emotionality. The undernourished animals were significantly (p < .01) more active than the adequately nourished controls whereas the larger, well nourished animals reared on their hind legs more frequently in an exploratory situation. Data on brain composition showed that the animals undernourished during suckling had smaller brains, with fewer cells as measured by DNA content (p < .01) than those adequately nourished from birth. An adequate diet introduced at weaning did not stimulate cell proliferation. Those animals deprived five or more weeks had significantly less total brain cholesterol than those rehabilitated after deprivation during sucking only (p < .01). This confirms other findings and shows that the critical period for cholesterol deposition indicative of myelin formation is in the first five weeks of life. There were no differences in the phospholipid phosphorus content of brains of deprived and adequately nourished rats. RNA values did not differ significantly among groups but were correlated r = 0.90 with DNA values. RNA: DNA ratios were approximately 1.0 for all groups. On the basis of weight there were no differences in the chemical composition of the brains of deprived and well nourished control rats. The animals with smaller brains learned to avoid shock in a shuttle box equally as well as well-nourished controls with larger brains of similar chemical composition and were significantly (p < .01) more active.
Subjects/Keywords: Rats; Nutrition; Brain
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APA (6th Edition):
Guthrie, H. A. (2009). Undernutrition, brain composition and behavior in rats. (Thesis). University of Hawaii. Retrieved from http://hdl.handle.net/10125/11313
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Guthrie, Helen Andrews. “Undernutrition, brain composition and behavior in rats.” 2009. Thesis, University of Hawaii. Accessed August 18, 2019.
http://hdl.handle.net/10125/11313.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Guthrie, Helen Andrews. “Undernutrition, brain composition and behavior in rats.” 2009. Web. 18 Aug 2019.
Vancouver:
Guthrie HA. Undernutrition, brain composition and behavior in rats. [Internet] [Thesis]. University of Hawaii; 2009. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/10125/11313.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Guthrie HA. Undernutrition, brain composition and behavior in rats. [Thesis]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/11313
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of KwaZulu-Natal
18.
[No author].
Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
Degree: Pharmacy and pharmacology, 2008, University of KwaZulu-Natal
URL: http://hdl.handle.net/10413/1171
► Background: Evidence from our laboratories indicates that triterpene constituents of Syzygium cordatum (Hochst.) [Myrtaceae] crude leaf extracts can be used to treat diabetes mellitus. For…
(more)
▼ Background: Evidence from our laboratories indicates that triterpene constituents of Syzygium cordatum (Hochst.) [Myrtaceae] crude leaf extracts can be used to treat diabetes mellitus. For the plant derived triterpenes to have further potential in diabetes management, they should, however, additionally alleviate or prevent some of the complications of diabetes mellitus such as impaired kidney function and cardiovascular disorders. Accordingly, this study was designed to isolate the triterpene, oleanolic acid (OA) from S. cordatum leaves and evaluate its effects on blood glucose, renal function and blood pressure in streptozotocin (STZ)-induced diabetic rats. OA was studied because it is the major constituent of many African plant species used in traditional medicine. Materials and Methods S. cordatum crude leaf ethyl acetate solubles (EAS) were obtained after defatting the leaves with hexane followed by dichloromethane before maceration with ethyl acetate. Preliminary experiments indicated that EAS contained triterpenes with hypoglycaemic properties. Solvent extraction and fractionation of EAS yielded mixtures of oleanolic acid/ursolic acid (OA/UA) and methyl maslinate/methyl corosolate. Recrystallisation of the OA/UA mixture using ethanol yielded OA, the structure of which was confirmed by NMR spectroscopy ('H & 13C). Oral glucose tolerance test (OGTT) responses to various doses of OA (40, 80 and 120 mg/kg) were monitored in separate groups of non-diabetic and STZ-induced diabetic rats given a glucose load (0.86 g/kg, p.o.) after an 18-h fast. Rats treated with deionized water (3 ml/kg p.o.), or standard drugs, (insulin, 200 Hg/kg, s.c; metformin, 500 mg/kg, p.o. and glibenclamide, 500 f^g/kg, p.o.) acted as untreated and treated positive controls, respectively. To investigate the possible interaction between OA and standard drugs in lowering blood glucose, OGTT responses were studied in separate groups of animals simultaneously treated with OA at either 40 or 80 mg/kg and insulin (100 or 200 ug/kg, s.c), metformin, (250 or 500 mg/kg, p.o.) or glibenclamide (250 or 500 mg/kg, p.o.). Blood glucose was monitored at 15-min intervals for the first hour, and hourly thereafter for 3 h. Plasma insulin concentrations were measured in separate parallel groups of rats prepared as for OGTT studies to examine whether there was an association between OA treatment and pancreatic insulin secretion. Acute effects of OA on kidney function and mean arterial blood pressure (MAP) were investigated in anaesthetized rats challenged with hypotonic saline after a 3'/2-h equilibration for 4 h consisting of 1 h control, 1XA h treatment and 1 Vi h recovery periods. OA was added to the infusate during the treatment period. Short-term effects of OA were studied in individually-caged rats treated twice daily with OA (80 mg/kg, p.o.) for 5 weeks. Results OA decreased blood glucose concentrations of both non-diabetic and diabetic rats, as did some standard drugs except glibenclamide which did not exhibit any effects in STZ-induced diabetic…
Subjects/Keywords: Renal effects – Rats.;
Streptozotocin – Rats.;
Diabetes – Rats.;
Pharmacy and pharmacology.
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APA (6th Edition):
author], [. (2008). Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
(Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/1171
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
author], [No. “Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
” 2008. Thesis, University of KwaZulu-Natal. Accessed August 18, 2019.
http://hdl.handle.net/10413/1171.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
author], [No. “Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
” 2008. Web. 18 Aug 2019.
Vancouver:
author] [. Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
[Internet] [Thesis]. University of KwaZulu-Natal; 2008. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/10413/1171.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
author] [. Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
[Thesis]. University of KwaZulu-Natal; 2008. Available from: http://hdl.handle.net/10413/1171
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
The Ohio State University
20.
Howard, Richard Lee.
An exploration of the relative importance of motivation and
interference in the motivational control of retrograde amnesia in
rats.
Degree: PhD, Graduate School, 1975, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705
Subjects/Keywords: Psychology; Rats
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APA (6th Edition):
Howard, R. L. (1975). An exploration of the relative importance of motivation and
interference in the motivational control of retrograde amnesia in
rats. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705
Chicago Manual of Style (16th Edition):
Howard, Richard Lee. “An exploration of the relative importance of motivation and
interference in the motivational control of retrograde amnesia in
rats.” 1975. Doctoral Dissertation, The Ohio State University. Accessed August 18, 2019.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705.
MLA Handbook (7th Edition):
Howard, Richard Lee. “An exploration of the relative importance of motivation and
interference in the motivational control of retrograde amnesia in
rats.” 1975. Web. 18 Aug 2019.
Vancouver:
Howard RL. An exploration of the relative importance of motivation and
interference in the motivational control of retrograde amnesia in
rats. [Internet] [Doctoral dissertation]. The Ohio State University; 1975. [cited 2019 Aug 18].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705.
Council of Science Editors:
Howard RL. An exploration of the relative importance of motivation and
interference in the motivational control of retrograde amnesia in
rats. [Doctoral Dissertation]. The Ohio State University; 1975. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486992852268705
University of Utah
21.
White, Harold Steve.
In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;.
Degree: PhD, Pharmacology & Toxicology;, 1984, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667
► Various parameters of anion and cation transport were measured in the cerebral cortex of neonatal (3 days old) and adult rats following acute and chronic…
(more)
▼ Various parameters of anion and cation transport were measured in the cerebral cortex of neonatal (3 days old) and adult rats following acute and chronic treatment with PHT. Acutely, phenytoin (PHT) significantly inhibited the enzyme Na+, K+-ATPase in both neonatal and adult rats. This effect was accompanied by a significant increase in cerebral cortical sodium (Na+) content and a decrease in potassium (K+) content only in neonatal animals. Chronic treatment (bid and qid for 7 days) of adult rats with PHT significantly reduced the Na+ content without affecting the whole homogenate Na+, K+-ATPase activity. The activity of this enzyme was markedly increased in the myelin- (glial product) and slightly decreased in the synaptosomal- (neuronal) fractions following chronic (qid for 7 days) PHT treatment. These results suggest that PHT differentially affects the two forms (neuronal and glial) of the enzyme Na+, K+-ATPase. The possible relevance of this hypothesis in relationship to the anticonvulsant and excitatory properties of PHT is discussed. Chronic (bid and qid for 7 days) PHT treatment increased both DNA content and activity of the glial marker enzyme carbonic anhydrase. Activity of the mitochondrial enzyme HCO3-C1-ATPase was also increased following chronic PHT treatment. These two enzymes are intimately involved in the regulation of HCO3[-]-C1- transport across glial cell and mitochondrial membranes, and these results suggest that PHT is able to beneficially effect glial regulatory processes. The ability to enhance glial regulation of extracellular fluid anions and cations provides new and important insights into the mechanism of the anticonvulsant action of PHT. The activity of enzymes involved in anion and cation transport, the concentration of intracellular potassium (K+i), and the trans-membrane potential (Em) was determined following acute and chronic exposure of primary astroglial cultures to micro-molar concentrations of phenytoin (PHT). Na+, K+-ATPase activity of homogenates of cultured glial cells was determined in the presence of increasing K+ concentration (1-20 mM). Acutely, PHT had little effect on the K+-activation pattern of Na+, K+-ATPase. In contrast, the percent of Na+, K+-ATPase activated by elevating the K+ concentration was dose-dependently increased by chronic PHT treatment. This effect was accompanied by a marked increase in K+i and a significant membrane hyper polarization. The acute effect of PHT on the Em was biphasic, characterized by membrane hyper polarization at concentrations of 1 x 10[-6] to 1 x 10[-5] M. At concentrations between 1 x 10[-5] M and 1 x 10[-4] M, the Em progressively returned to control values. These results suggest that glial cells acutely and chronically treated with therapeutic concentrations of PHT have an enhanced capacity to control elevated extracellular potassium. Return of the Em to control values at PHT concentrations greater than 1 x 10[-5] M suggest that these cells are less able to regulate extracellular potassium. These data can partially explain the…
Subjects/Keywords: Physiology; Rats
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APA (6th Edition):
White, H. S. (1984). In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667
Chicago Manual of Style (16th Edition):
White, Harold Steve. “In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;.” 1984. Doctoral Dissertation, University of Utah. Accessed August 18, 2019.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667.
MLA Handbook (7th Edition):
White, Harold Steve. “In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;.” 1984. Web. 18 Aug 2019.
Vancouver:
White HS. In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;. [Internet] [Doctoral dissertation]. University of Utah; 1984. [cited 2019 Aug 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667.
Council of Science Editors:
White HS. In vivo and in vitro effects of phenytoin on anion and cation transport systems of the rat brain;. [Doctoral Dissertation]. University of Utah; 1984. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1393/rec/667
University of Utah
22.
Noordewier, Byron.
Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;.
Degree: PhD, Pharmacology & Toxicology;, 1976, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429
► The effect of pretreatment with penicillin on para-aminohippurate (PAH) transport by kidney of the immature rat was evaluated in vivo. After 3 days of penicillin…
(more)
▼ The effect of pretreatment with penicillin on para-aminohippurate (PAH) transport by kidney of the immature rat was evaluated in vivo. After 3 days of penicillin administration, the renal clearances of inulin (CIN), PAH(CPAH), and N-methylnicotinamide (CNMN) and the rental tubular transport maximum (Tm) for PAH were measured in rats as young as 17 days of age. The CPAH by 19- to 21-day old rats pretreated with procaine penicillin was 46% greater than that of there litter-mate controls. Similarly, CPAH of rats that received sodium penicillin was 27% greater than control. CIN was not increased after penicillin pretreatment. Pretreatment with penicillin of rats older than 24 days of age did not change CIN or CPAH. The Tm for PAH of 17-day-old rats pretreated with sodium penicillin was 51% greater than that of control rats. Sodium penicillin-pretreated rats had a lower CNMN that did control rats. These results are in contrast with the normal pattern of renal maturation in which CIN, CPAH, and PAH Tm all increase with age. It was concluded that pretreatment with penicillin stimulates the renal secretion of organic anions by the immature rat.
Subjects/Keywords: Rats; Physiology
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APA (6th Edition):
Noordewier, B. (1976). Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429
Chicago Manual of Style (16th Edition):
Noordewier, Byron. “Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;.” 1976. Doctoral Dissertation, University of Utah. Accessed August 18, 2019.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429.
MLA Handbook (7th Edition):
Noordewier, Byron. “Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;.” 1976. Web. 18 Aug 2019.
Vancouver:
Noordewier B. Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;. [Internet] [Doctoral dissertation]. University of Utah; 1976. [cited 2019 Aug 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429.
Council of Science Editors:
Noordewier B. Effects of penicillin pretreatment on renal tubular para-aminohippurate transport in the immature rat;. [Doctoral Dissertation]. University of Utah; 1976. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1579/rec/429
University of Utah
23.
Goodnight, James Edgar.
Determination of factors responsible for long-term survival of rat heart allografts;.
Degree: PhD, Pathology;, 1976, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299
► Long-term survival of whole organ allografts can be obtained without the use of chronic nonspecific immunosuppression. Administration of anti-donor antibody or donor antigen to the…
(more)
▼ Long-term survival of whole organ allografts can be obtained without the use of chronic nonspecific immunosuppression. Administration of anti-donor antibody or donor antigen to the host or short-term treatment of the host with anti-lymphocytic serum (ALS) is some of the methods most commonly used to induce this phenomenon. A steady state is produced in the host in which the allograft appears safe from rejection even though the host retains a capacity to respond to donor antigens and is able to reject allografts from other donors in normal fashion. The mechanisms underlying this phenomenon have not been completely defined. In this study, long-term survival of Ag-B compatible rat heart allografts was obtained by short-term treatment of the recipients with ALS. Graft survival apparently was based on a specific change in the hosts rather than on persistent nonspecific effects of ALS. The hosts were not fully tolerant in that they were able to reject secondary skin allografts from the heart donor strain, through in a delayed fashion. The long-surviving heart allografts retained their immunogenicity as they were rejected when retransplanted to new hosts. The passive transfer of serum from long-term heart graft acceptors to new host receiving fresh allografts delayed rejection by several days. This effect was seen only with the serum from long-term acceptors suggesting that serum-blocking factors were involved in long-term survival of the heart. allografts. However, the ability of aboptively transferred lymphoid cell to break tolerance to a heart allograft residing in a classically tolerant host was tested.. In contrast to normal lymphoid cells, cells from the long-term acceptors were unable to break tolerance, suggesting that a specific cellular tolerance had been induced in this cell population. Moreover, serum from the long-term acceptors failed to block the breakage of tolerance by normal lymphoid cells. The overriding factor in obtaining long-term heart allograft survival is a predisposition in a particular host-recipient combination towards an enhancement response. Inbred rat strains, Fischer (Fi) and Lewis (Le), share the serological Ag-B1 allele and react very weakly in a mixed lymphocyte culture (MLC). In spite of this apparent identity an Ag-B, these strains differ markedly in their immune responses to histocompatibility antigens from an Ag-B disparate third strain, Marshall (Ma) (Ag-B6). Fi recipients allowed Ma heart grafts an extended survival where as Le recipients rejected them rapidly. Fi and Ma showed a weak response to MLC in contrast to a strong response for Le and Ma. Fi produced antisera in response to Ma which had a relatively high titer of antibody but low cytotoxic activity. Fi responded to another strain, Buffalo (Buf) (also Ag-B6), in a similar fashion. Fi apparently can produce a strong allogeneic response as it was able to reject LBN (Ag-B1/3) heart grafts rapidly. The low response of Fi and Ma probably was not due to shared antigens between the two strains because Ma heart grafts underwent rapid…
Subjects/Keywords: Heart; Rats
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APA (6th Edition):
Goodnight, J. E. (1976). Determination of factors responsible for long-term survival of rat heart allografts;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299
Chicago Manual of Style (16th Edition):
Goodnight, James Edgar. “Determination of factors responsible for long-term survival of rat heart allografts;.” 1976. Doctoral Dissertation, University of Utah. Accessed August 18, 2019.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299.
MLA Handbook (7th Edition):
Goodnight, James Edgar. “Determination of factors responsible for long-term survival of rat heart allografts;.” 1976. Web. 18 Aug 2019.
Vancouver:
Goodnight JE. Determination of factors responsible for long-term survival of rat heart allografts;. [Internet] [Doctoral dissertation]. University of Utah; 1976. [cited 2019 Aug 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299.
Council of Science Editors:
Goodnight JE. Determination of factors responsible for long-term survival of rat heart allografts;. [Doctoral Dissertation]. University of Utah; 1976. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/790/rec/299
University of Utah
24.
Warren, Reed Parley.
Factors responsible for the differential survival of heart and skin allografts in inbred rats.
Degree: PhD, Pathology;, 1973, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1620/rec/480
► It is common observation that orthotopic skin allografts are rejected acutely across certain histoincompatibility barriers in which surgically anastomosed hearts often survive for many months.…
(more)
▼ It is common observation that orthotopic skin allografts are rejected acutely across certain histoincompatibility barriers in which surgically anastomosed hearts often survive for many months. In three normal or treated rat strain combinations that exhibit this pattern, neonatal heart tissue grafted in a free manner analogous to skin grafting (requiring natural vascularization, ischemic stress etc.) was also found to be rejected acutely. Consequently the differential survival of surgically anastomosed heart and skin allografts seems due to differences in the mode of grafting these tissues and not to different tissue specific antigens or inherent differential vulnerability of skin and heart. In addition the survival of these freely grafted heart as well as skin allografts were greatly extended when they were transplanted with surgically anastomosed hearts of the same inbred strain. This extension of survival appeared to result from the ability of surgically anastomosed hearts to induce unresponsiveness in their recipients. Subsequent experiments characterized this unresponsiveness as being immunological enhancement. Sera from heart organ allograft recipients passively enhanced the survival of freely grafted heart allografts. In addition, by the leucocyte migration test, lymph node cells and sera, respectively, from some of the heart recipients produced migration inhibition factor when exposed to antigen in culture and blocked production of the same.
Subjects/Keywords: Immunology; Rats
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APA ·
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APA (6th Edition):
Warren, R. P. (1973). Factors responsible for the differential survival of heart and skin allografts in inbred rats. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1620/rec/480
Chicago Manual of Style (16th Edition):
Warren, Reed Parley. “Factors responsible for the differential survival of heart and skin allografts in inbred rats.” 1973. Doctoral Dissertation, University of Utah. Accessed August 18, 2019.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1620/rec/480.
MLA Handbook (7th Edition):
Warren, Reed Parley. “Factors responsible for the differential survival of heart and skin allografts in inbred rats.” 1973. Web. 18 Aug 2019.
Vancouver:
Warren RP. Factors responsible for the differential survival of heart and skin allografts in inbred rats. [Internet] [Doctoral dissertation]. University of Utah; 1973. [cited 2019 Aug 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1620/rec/480.
Council of Science Editors:
Warren RP. Factors responsible for the differential survival of heart and skin allografts in inbred rats. [Doctoral Dissertation]. University of Utah; 1973. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1620/rec/480
University of Utah
25.
Leslie, John Gregory.
Studies on the structure and metabolism of elastin and collagen;.
Degree: PhD, Pathology;, 1980, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1402/rec/1272
► The structure and metabolism of elastin and collagen were studied in three sets of experiments. In the first experiment, porcine tropoelastin was digested with the…
(more)
▼ The structure and metabolism of elastin and collagen were studied in three sets of experiments. In the first experiment, porcine tropoelastin was digested with the endopeptidase, thermolysin. The digest contained at least 35 groups of peptides. The polydispersed peptides included large nonpolar peptides, 50-60 residues in length, and a series of gradations to polar peptides of 10 residues and less. The largest peptide sequenced was a portion of the tryptic peptide T1, which contained the pentapeptide repeat P G V G V. This region was enzyme resistant, implying that the peptide was in some sort of conformation unavailable to the thermolysin. Very likely, it is similar to the B-spiral which is composed of the pentapeptide repeat proposed by Urry. Two small polar peptides were also sequenced. One was shown to extend 2 residues amino terminal to peptide T7a. The other was previously unknown, its sequence being: I G G K P P K P G. Because of the two lysines and the rigid proline structure, it may be involved in some sort of crosslinking function. Overall, thermolysin appeared to cleave the hydrophilic crosslink regions of tropoelastin more extensively than the large hydrophobic regions. In the second experiment, elastin and collagen metabolism were analyzed from the upper thorax to the abdomen in the young pig aorta, in vitro. Tissue was incubated with either ('14)C leucine, ('14)C valine, ('3)H valine, or ('3)H proline for 1, 2, or 24 hours. The tissue was extracted with detergent, urea, and autoclaving. Total incorporated radioactivity was higher in the upper thorax than in the abdomen during the 1 or 2 hour incubations. Most of the radioactivity was seen in valine-rich soluble proteins. However, after a 24 hour incubation the abdomen was the most radioactive region. The label was primarily in the autoclaved supernate, and it reflected collagen formation as shown by ('3)H hydroxyproline production. From this, it was concluded that collagen formation did not appear to be altered significantly in vitro, while elastin formation was markedly altered. Thus, quantitative questions about elastin metabolism must be answered through experiments conducted in vivo. The third experiment involved analyzing elastin and collagen metabolism from the upper thorax to the abdomen of 4-6 week and 2 day old rat aortas, in vivo. Rats were injected intraperitoneally with ('3)H glycine and then sacrificed at specified times after injection. Soluble and insoluble elastin and collagen were isolated. In the 2 day old rat little radioactivity in tropoelastin was isolated. The elastin showed an increase in the accumulation of radioactivity in the upper thorax as compared to the abdomen. Synthesis of radioactive soluble collagen was higher in the abdomen, but this was not reflected by increased accumulation of radioactivity into insoluble collagen. Finally, radioactivity in both elastin and collagen appeared to accumulate at the same relative rates. In the 6 week old rat, again little radioactivity in tropoelastin was isolated. This indicated that…
Subjects/Keywords: Biology; Rats
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APA (6th Edition):
Leslie, J. G. (1980). Studies on the structure and metabolism of elastin and collagen;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1402/rec/1272
Chicago Manual of Style (16th Edition):
Leslie, John Gregory. “Studies on the structure and metabolism of elastin and collagen;.” 1980. Doctoral Dissertation, University of Utah. Accessed August 18, 2019.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1402/rec/1272.
MLA Handbook (7th Edition):
Leslie, John Gregory. “Studies on the structure and metabolism of elastin and collagen;.” 1980. Web. 18 Aug 2019.
Vancouver:
Leslie JG. Studies on the structure and metabolism of elastin and collagen;. [Internet] [Doctoral dissertation]. University of Utah; 1980. [cited 2019 Aug 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1402/rec/1272.
Council of Science Editors:
Leslie JG. Studies on the structure and metabolism of elastin and collagen;. [Doctoral Dissertation]. University of Utah; 1980. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1402/rec/1272
University of Utah
26.
Nagel, Timothy Lee.
In vivo surface localized phosphorous nuclear magnetic resonance spectroscopy with a slotted crossover surface coi;.
Degree: MS;, Biomedical Informatics;, 1989, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/533/rec/670
► The development of a technique for noninvasive in vivo phosphorous (31P) nuclear magnetic resonance (NMR) spectroscopy of skin tissue is presented. Tissue viability is often…
(more)
▼ The development of a technique for noninvasive in vivo phosphorous (31P) nuclear magnetic resonance (NMR) spectroscopy of skin tissue is presented. Tissue viability is often difficult to evaluate clinically. In vitro NMR of skin flaps and grafts completed by other authors via acid extractions has shown predictive correlates for clinical applications. Problems making in vivo non-invasive surface localized spectroscopy impractical for studying intact skin tissue involved inadequate SNR and localization effects. The development of the conventional crossover surface coil and its modification to form the slotted crossover surface coil has made experiments of this nature feasible for the first time. In vivo spectra have been acquired in as little as 5 minutes at 2 Tesla with localization depths from 1 to 4mm. The crossover surface coil is constructed with two turns of copper foil using a unique transposition construction that incorporates an explicit center tap ground of the widened bottom layer. The coil reduces dielectric and inductive losses by effective shielding of electric fields and uniform distribution of magnetic fields for minimum quality factor (Q) losses upon coil loading. Flexible, copper foil construction permits easy conformation to tissues of interest enhancing coil performance. Construction details of the crossover coil and Q data for coils of various sizes at a number of frequencies are given. The slotted crossover surface coil incorporates advances of the conventional crossover surface coil with a modified shape format. Enhanced signal-to-noise ratios (SNR) are achieved via reduced coil-samples loses a smaller coil radius, close probe-to-sample conformation, increased copper surface area, and maximized region-of-interest (ROI) tissue presentation to the probe. The slotted shape effectively reduces the coil diameter, thus, minimizing B1 field penetration and producing an innate localization effect. Utilization of single broad band pulse followed by acquisition eliminates SNR losses associated with pulse sequence localization schemes. Surface localized depth selection is achieved using different predetermined pulse widths. Preliminary in vivo experiments using the slotted crossover surface coil at 2 Tesla to characterize normal and burned rat skin tissue demonstrated its research and clinical implications. It appears that burn severity and tissue viability determinations are possible using PCr/Pi ratios. These rations show significant reduction proportional to burn severity. Hypermetabolic processes were also observed in a partial-thickness burn via increasing rations and PCr metabolite concentrations. This technique may provide a noninvasive tool for the collection of clinical information relevant to diagnoses, physiological status, treatment efficacy, and prognostic indices.
Subjects/Keywords: Rats; Skin
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APA (6th Edition):
Nagel, T. L. (1989). In vivo surface localized phosphorous nuclear magnetic resonance spectroscopy with a slotted crossover surface coi;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/533/rec/670
Chicago Manual of Style (16th Edition):
Nagel, Timothy Lee. “In vivo surface localized phosphorous nuclear magnetic resonance spectroscopy with a slotted crossover surface coi;.” 1989. Masters Thesis, University of Utah. Accessed August 18, 2019.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/533/rec/670.
MLA Handbook (7th Edition):
Nagel, Timothy Lee. “In vivo surface localized phosphorous nuclear magnetic resonance spectroscopy with a slotted crossover surface coi;.” 1989. Web. 18 Aug 2019.
Vancouver:
Nagel TL. In vivo surface localized phosphorous nuclear magnetic resonance spectroscopy with a slotted crossover surface coi;. [Internet] [Masters thesis]. University of Utah; 1989. [cited 2019 Aug 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/533/rec/670.
Council of Science Editors:
Nagel TL. In vivo surface localized phosphorous nuclear magnetic resonance spectroscopy with a slotted crossover surface coi;. [Masters Thesis]. University of Utah; 1989. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/533/rec/670
University of Alberta
27.
Lakey, Jonathan Robert Todd.
Determining the optimal conditions for hypothermic rat
pancreas preservation.
Degree: MS, Department of Zoology, 1990, University of Alberta
URL: https://era.library.ualberta.ca/files/8k71nk445
Subjects/Keywords: Rats – Pancreas.; Rats – Physiology.; Rats – Dissection.; Rats – Anatomy.
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Lakey, J. R. T. (1990). Determining the optimal conditions for hypothermic rat
pancreas preservation. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/8k71nk445
Chicago Manual of Style (16th Edition):
Lakey, Jonathan Robert Todd. “Determining the optimal conditions for hypothermic rat
pancreas preservation.” 1990. Masters Thesis, University of Alberta. Accessed August 18, 2019.
https://era.library.ualberta.ca/files/8k71nk445.
MLA Handbook (7th Edition):
Lakey, Jonathan Robert Todd. “Determining the optimal conditions for hypothermic rat
pancreas preservation.” 1990. Web. 18 Aug 2019.
Vancouver:
Lakey JRT. Determining the optimal conditions for hypothermic rat
pancreas preservation. [Internet] [Masters thesis]. University of Alberta; 1990. [cited 2019 Aug 18].
Available from: https://era.library.ualberta.ca/files/8k71nk445.
Council of Science Editors:
Lakey JRT. Determining the optimal conditions for hypothermic rat
pancreas preservation. [Masters Thesis]. University of Alberta; 1990. Available from: https://era.library.ualberta.ca/files/8k71nk445
University of Canterbury
28.
van Nobelen, Marion.
Fear, Pain and the Amygdaloid Complex.
Degree: Psychology, 2009, University of Canterbury
URL: http://hdl.handle.net/10092/4436
► In classical conditioning the amygdala is a critical area for the convergence of the unconditioned (US) and conditioned stimulus (CS). During this process the CS…
(more)
▼ In classical conditioning the amygdala is a critical area for the convergence of the unconditioned (US) and conditioned stimulus (CS). During this process the CS acquires some of the properties of the US. By assessing the US properties of foot-shock, namely reflex, pain and fear, the neural systems of pain and fear were evaluated in the rat basolateral and central amygdala. The central fear state produced by footshock was compared to the central fear state expressed during the fear-potentiated startle paradigm. By analysing the similarities and differences in the fear states, the effects of GABAergic, glutamatergic, and dopaminergic systems and protein synthesis inhibition on these fear states were investigated.
The basolateral amygdala was sensitive to GABAergic modulation during US and CS presentations. This was interpreted as a central fear effect. The central amygdala was sensitive to glutamate but not to GABAergic modulation. NMDA receptor antagonism prevented fear arousal to US but not CS presentation. This effect was interpreted as a deficit in pain processing. Non-NMDA receptor antagonism could significantly attenuate both US and CS fear expression. This was interpreted as an overall non-NMDA receptor inhibitory effect that affected pain and conditioned fear expression. Results of these experiments have implications for our understanding of the circuitry involved in processing the US. The basolateral amygdala appears to support emotional neural plasticity while the central amygdala appears to support pain neural plasticity. Finally and and most importantly each area processes different properties of the US.
Subjects/Keywords: fear; pain; amygdaloid complex; rats
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APA (6th Edition):
van Nobelen, M. (2009). Fear, Pain and the Amygdaloid Complex. (Thesis). University of Canterbury. Retrieved from http://hdl.handle.net/10092/4436
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
van Nobelen, Marion. “Fear, Pain and the Amygdaloid Complex.” 2009. Thesis, University of Canterbury. Accessed August 18, 2019.
http://hdl.handle.net/10092/4436.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
van Nobelen, Marion. “Fear, Pain and the Amygdaloid Complex.” 2009. Web. 18 Aug 2019.
Vancouver:
van Nobelen M. Fear, Pain and the Amygdaloid Complex. [Internet] [Thesis]. University of Canterbury; 2009. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/10092/4436.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
van Nobelen M. Fear, Pain and the Amygdaloid Complex. [Thesis]. University of Canterbury; 2009. Available from: http://hdl.handle.net/10092/4436
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
The Ohio State University
29.
Zhou, Xiaodong.
The effect of estrogen status on selenium metabolism in
female rats.
Degree: PhD, Human Nutrition and Food Management, 2007, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985
► An association between male and female sex hormones and selenium status has been reported in animals and humans. These relationships may be important in the…
(more)
▼ An association between male and female sex hormones
and selenium status has been reported in animals and humans. These
relationships may be important in the regulation of selenium
metabolism and relative to the possible use of selenium as an
adjunct for treatment of hormone-related diseases such as breast
cancer. The purpose of the first study was to examine the effect of
estrogen status on the absorption, tissue distribution and
metabolism of orally administered 75Se-selenite. Female Sprague
Dawley
rats were bilaterally ovariectomized and implanted with
either a placebo pellet (OVX) or pellet with estradiol (OVX+E2) at
7 weeks of age. At 12 weeks of age, 60 µCi of 75Se as selenite was
orally administered to each rat. Blood and organs were collected 1,
3, 6, and 24h after dosing. Although apparent absorption of 75Se
was independent of estrogen status, hormone associated differences
of 75Se levels were noted in plasma, RBC, liver, heart, kidney,
spleen, brain, and thymus at certain times. Plasma selenoprotein P
(SelP) in OVX+E2 group contained a greater percentage of
administered 75Se at 3, 6 and 24h after gavage compared to OVX
group. 75Se in plasma glutathione peroxidase (GPx) also was greater
in OVX+E2 compared to OVX group at 24h. The second aim was to
investigate the effect of estrogen status on selenium status in
tissues, and on hepatic mRNA levels of SelP and GPx1. Estrogen
significantly increased selenium status as measured by selenium
concentration and GPx activity in plasma, liver, and brain.
Selenium concentration in RBC was also increased by estrogen
treatment. Selenium status in kidney and heart was independent of
estrogen treatment. Real-time RT-PCR analysis demonstrated that
both hepatic SelP and GPx1 mRNA were significantly increased by
estrogen treatment. In conclusion, these results suggest that
estrogen status affects distribution of ingested selenium in
tissue- and time-dependent manners. Expression of hepatic SelP and
GPx was regulated by estrogen at both mRNA and protein levels. As
SelP has been shown to function as a selenium transporter, estrogen
regulation of SelP may play an important role in whole body
metabolism of selenium.
Advisors/Committee Members: Smith, Anne (Advisor).
Subjects/Keywords: selenium; estrogen; selenoproteins; ovariectomized rats
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APA (6th Edition):
Zhou, X. (2007). The effect of estrogen status on selenium metabolism in
female rats. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985
Chicago Manual of Style (16th Edition):
Zhou, Xiaodong. “The effect of estrogen status on selenium metabolism in
female rats.” 2007. Doctoral Dissertation, The Ohio State University. Accessed August 18, 2019.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985.
MLA Handbook (7th Edition):
Zhou, Xiaodong. “The effect of estrogen status on selenium metabolism in
female rats.” 2007. Web. 18 Aug 2019.
Vancouver:
Zhou X. The effect of estrogen status on selenium metabolism in
female rats. [Internet] [Doctoral dissertation]. The Ohio State University; 2007. [cited 2019 Aug 18].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985.
Council of Science Editors:
Zhou X. The effect of estrogen status on selenium metabolism in
female rats. [Doctoral Dissertation]. The Ohio State University; 2007. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1179976985
Oregon State University
30.
Warren, Edward Perrin.
Reproductive performance in the rat in relation to selection for time of puberty.
Degree: PhD, Animal Husbandry, 1951, Oregon State University
URL: http://hdl.handle.net/1957/51787
Subjects/Keywords: Rats – Reproduction
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APA ·
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APA (6th Edition):
Warren, E. P. (1951). Reproductive performance in the rat in relation to selection for time of puberty. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/51787
Chicago Manual of Style (16th Edition):
Warren, Edward Perrin. “Reproductive performance in the rat in relation to selection for time of puberty.” 1951. Doctoral Dissertation, Oregon State University. Accessed August 18, 2019.
http://hdl.handle.net/1957/51787.
MLA Handbook (7th Edition):
Warren, Edward Perrin. “Reproductive performance in the rat in relation to selection for time of puberty.” 1951. Web. 18 Aug 2019.
Vancouver:
Warren EP. Reproductive performance in the rat in relation to selection for time of puberty. [Internet] [Doctoral dissertation]. Oregon State University; 1951. [cited 2019 Aug 18].
Available from: http://hdl.handle.net/1957/51787.
Council of Science Editors:
Warren EP. Reproductive performance in the rat in relation to selection for time of puberty. [Doctoral Dissertation]. Oregon State University; 1951. Available from: http://hdl.handle.net/1957/51787
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