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Texas A&M University
1.
Redmond, Jeremy Scott.
Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb.
Degree: MS, Physiology of Reproduction, 2012, Texas A&M University
URL: http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8928
► Increased pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is critical for pubertal initiation of ovarian cycles in female mammals. Kisspeptin, a peptide…
(more)
▼ Increased pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is critical for pubertal initiation of ovarian cycles in female mammals. Kisspeptin, a peptide product of the Kiss1 gene, is required for normal
puberty. In Experiment 1, ovariectomized ewe lambs bearing subcutaneous estradiol implants were used to investigate Kiss1 gene expression in the preoptic area (POA) and hypothalamus during pubertal maturation of the reproductive neuroendocrine system. Brain tissue was collected from ewes at 25, 30, and 35 wk of age (n=6/group). Patterns of LH release in circulation were determined on the day before euthanasia and cells containing Kiss1-mRNA were identified by in situ hybridization. Mean concentrations of LH and the frequency of LH pulses increased (P < 0.01) as ewe lambs matured. In the POA/Periventricular area (PEV), the number of Kiss1-expressing cells was greater (P < 0.04) in 30- and 35-wk-old than in 25-wk-old ewe lambs. In the arcuate nucleus (ARC), although no significant changes in number Kiss1-expressing cells were observed among age groups, the number of Kiss1 cells increased (P < 0.02) with increased frequency of LH release. This resulted in greater (P < 0.01) number of Kiss1 cells in the ARC of ewes demonstrating elevated frequency (> 6 pulses/12 h) of LH pulses. In Experiment 2, 28-wk-old ewe lambs were used to determine the effects of intermittent injections of kisspeptin on the release of LH and stimulation of gonadal function in peripubertal ewe lambs. Ewe lambs were treated intravenously with saline (Controls; n=6) or kisspeptin (n=6) hourly for 24 h. Blood samples were collected throughout the experiment for hormone analysis. Kisspeptin-treated lambs had greater (P < 0.02) mean circulating concentrations of LH, and frequency and amplitude of LH pulses than controls. Four of six kisspeptin-treated ewe lambs exhibited LH surge and luteal activity in response to treatments. However, onset of regular estrous cycles was not established immediately following kisspeptin-induced ovulation and no difference in age at onset of
puberty was observed between groups. In conclusion, activation of the hypothalamic kisspeptin system may support elevated episodic release of LH critical for establishment of normal estrous cycle during pubertal development.
Advisors/Committee Members: Amstalden, Marcel (advisor), Williams, Gary L. (committee member), Abbott, Louise (committee member).
Subjects/Keywords: Kisspeptin; Puberty
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APA (6th Edition):
Redmond, J. S. (2012). Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8928
Chicago Manual of Style (16th Edition):
Redmond, Jeremy Scott. “Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb.” 2012. Masters Thesis, Texas A&M University. Accessed April 10, 2021.
http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8928.
MLA Handbook (7th Edition):
Redmond, Jeremy Scott. “Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb.” 2012. Web. 10 Apr 2021.
Vancouver:
Redmond JS. Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb. [Internet] [Masters thesis]. Texas A&M University; 2012. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8928.
Council of Science Editors:
Redmond JS. Kiss1 Gene Expression and the Effects of Kisspeptin During Pubertal Development in the Ewe Lamb. [Masters Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8928

University of Melbourne
2.
Sayer, Timothy Alexander.
Influence of female pubertal development and athletic footwear on lower limb biomechanics: implications for non-contact ACL injury and patellofemoral pain.
Degree: 2017, University of Melbourne
URL: http://hdl.handle.net/11343/208063
► Adolescent girls are susceptible to knee injuries such as non-contact anterior cruciate ligament (ACL) rupture and patellofemoral pain (PFP). Adolescence is synonymous with pubertal development…
(more)
▼ Adolescent girls are susceptible to knee injuries such as non-contact anterior cruciate ligament (ACL) rupture and patellofemoral pain (PFP). Adolescence is synonymous with pubertal development which drives substantial growth and maturation of the musculoskeletal system, and is thought to contribute to poor knee biomechanics associated with both of these injuries. Specifically, higher tri-planar knee moments during puberty (external peak knee abduction moment (KAbM), flexion moment (KFM) and internal rotation moment (KIRM)) are thought to contribute to a higher incidence of these injuries; however, there are still gaps in our understanding of female pubertal biomechanics. For instance, variations in dynamic tasks (i.e., bilateral vs single limb), unreliable pubertal classification methods, small sample sizes, conflicting findings and data normalisation methods (i.e., mixed between body mass or body mass by height) highlight the need for additional, better designed pubertal studies.
The role of athletic footwear is also an important consideration, given it may alter tri-planar knee moments relevant to both non-contact ACL rupture or PFP. Specifically, high-support footwear is thought to control excessive foot pronation, which may transfer up the kinetic chain and confer protection at the proximal knee joint by modifying tri-planar knee moments during dynamic tasks. By contrast, low-support shoes do not possess the same stability features, potentially allowing for greater foot pronation that may have a clinically meaningful effect on tri-planar knee moments compared to high-support shoes. Surprisingly, no studies have explored the effects of these shoes during female pubertal development, which is concerning as many adolescent girls are likely wearing these types of shoes during the various sports in which the aforementioned knee injuries occur.
To address the current limitations in pubertal and footwear biomechanical research, four cross-sectional studies are reported in this thesis. Ninety-three girls aged between 7-25 years old were categorised into three key stages of puberty: pre-pubertal (n = 31, mean age = 9.4 ± 1.2), early/mid-pubertal (n = 31, mean age = 11.1 ± 1.4) and late/post-pubertal (n = 31, mean age = 19.8 ± 4.0). Tri-planar knee moments normalised to body mass (Nm/kg) and body mass by height (Nm/kg/m) were analysed across landing and running-related tasks in each pubertal group. These were initially observed barefoot, and then subsequently, the effect of high- and low-support footwear was explored across both tasks.
The primary aim of Study 1 was to determine whether peak tri-planar knee moments differed between three stages of female pubertal development during a barefoot single limb drop lateral jumping (DLJ) task. The secondary aim was to explore the hip adduction moment (HAM) at time of peak KAbM and the hip flexion moment (HFM) at time of peak KFM between pubertal groups. In the frontal plane, a higher peak KAbM was found for the late/post- compared to the pre-pubertal group when…
Subjects/Keywords: puberty; biomechanics; footwear
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sayer, T. A. (2017). Influence of female pubertal development and athletic footwear on lower limb biomechanics: implications for non-contact ACL injury and patellofemoral pain. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/208063
Chicago Manual of Style (16th Edition):
Sayer, Timothy Alexander. “Influence of female pubertal development and athletic footwear on lower limb biomechanics: implications for non-contact ACL injury and patellofemoral pain.” 2017. Doctoral Dissertation, University of Melbourne. Accessed April 10, 2021.
http://hdl.handle.net/11343/208063.
MLA Handbook (7th Edition):
Sayer, Timothy Alexander. “Influence of female pubertal development and athletic footwear on lower limb biomechanics: implications for non-contact ACL injury and patellofemoral pain.” 2017. Web. 10 Apr 2021.
Vancouver:
Sayer TA. Influence of female pubertal development and athletic footwear on lower limb biomechanics: implications for non-contact ACL injury and patellofemoral pain. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/11343/208063.
Council of Science Editors:
Sayer TA. Influence of female pubertal development and athletic footwear on lower limb biomechanics: implications for non-contact ACL injury and patellofemoral pain. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/208063

Texas A&M University
3.
Lee, Bo Yeon.
Action of manganese on puberty.
Degree: PhD, Toxicology, 2007, Texas A&M University
URL: http://hdl.handle.net/1969.1/5871
► Manganese (Mn) is considered important for normal growth and reproduction. Because Mn can cross the blood brain barrier and accumulate in the hypothalamus, and because…
(more)
▼ Manganese (Mn) is considered important for normal growth and reproduction. Because Mn can cross the blood brain barrier and accumulate in the hypothalamus, and because it has been suggested that infants and children are potentially more sensitive to Mn than adults, we wanted to determine the effects of Mn exposure on
puberty-related hormones and the onset of
puberty, and discern the site and mechanism of Mn action. We demonstrated that the central administration of manganese chloride (MnCl2) stimulated luteinizing hormone (LH) release in prepubertal rats. Incubation of medial basal hypothalamus (MBH) in vitro showed this effect was due to a Mn-induced stimulation of luteinizing hormone releasing hormone (LHRH). Further demonstration that this is a hypothalamic site of action was shown by in vivo blockade of LHRH receptors and the lack of a direct pituitary action of Mn to stimulate LH release in vitro. Chronic supplementation of low dose of MnCl2 caused elevated serum levels of LH, follicle stimulating hormone (FSH) and estradiol or testosterone. Importantly, Mn supplementation advanced the timing of
puberty in both sexes. We investigated the mechanism by which Mn induces LHRH/LH release from the hypothalamus. Blocking the NMDA receptor, IGF1 receptor, or inhibiting nitric oxide synthase in vivo was ineffective in altering Mn-induced LH release. Dose-response, pharmacological blockade and nitrite assessments indicated that the lowest doses of Mn used stimulated LHRH release, but did not induce nitric oxide (NO) production, while only the highest dose of Mn stimulated NO. Conversely, a dose-dependent inhibition of Mn-induced LHRH release was observed in the presence of ODQ, a specific blocker of soluble guanylyl cyclase. Furthermore, Mn stimulated the release of cyclic GMP (cGMP) and LHRH from the same MBH, and a protein kinase G (PKG) inhibitor, KT5823, blocked Mn-induced LHRH release. Collectively, these data demonstrate that Mn can stimulate specific
puberty-related hormones both acutely and chronically, and furthermore, suggest that low levels of Mn facilitate the normal onset of
puberty. The principal action of Mn within the hypothalamus is to facilitate the activation of guanylyl cyclase, which subsequently stimulates the cGMP/PKG pathway resulting in the stimulation of prepubertal LHRH secretion.
Advisors/Committee Members: Dees, William Les (advisor), Bratton, Gerald R. (committee member), Porter, Weston William (committee member), Ramaiah, Shashi (committee member).
Subjects/Keywords: Manganese; Puberty
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, B. Y. (2007). Action of manganese on puberty. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/5871
Chicago Manual of Style (16th Edition):
Lee, Bo Yeon. “Action of manganese on puberty.” 2007. Doctoral Dissertation, Texas A&M University. Accessed April 10, 2021.
http://hdl.handle.net/1969.1/5871.
MLA Handbook (7th Edition):
Lee, Bo Yeon. “Action of manganese on puberty.” 2007. Web. 10 Apr 2021.
Vancouver:
Lee BY. Action of manganese on puberty. [Internet] [Doctoral dissertation]. Texas A&M University; 2007. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1969.1/5871.
Council of Science Editors:
Lee BY. Action of manganese on puberty. [Doctoral Dissertation]. Texas A&M University; 2007. Available from: http://hdl.handle.net/1969.1/5871

Texas A&M University
4.
Bedenbaugh, Michelle Nichole.
Regulation of ESR1 in Kisspeptin Neurons during Reproductive Maturation in Ewe Lambs.
Degree: MS, Physiology of Reproduction, 2014, Texas A&M University
URL: http://hdl.handle.net/1969.1/153860
► The pubertal initiation of a high-frequency, pulsatile release of gonadotropin-releasing hormone (GnRH) involves an escape from estradiol negative feedback. Kisspeptin neurons are proposed to mediate…
(more)
▼ The pubertal initiation of a high-frequency, pulsatile release of gonadotropin-releasing hormone (GnRH) involves an escape from estradiol negative feedback. Kisspeptin neurons are proposed to mediate the effects of estradiol, and estrogen receptor alpha (ESR1) may play a role in this process. The present study investigated the hypothesis that reduced ESR1 expression in kisspeptin neurons is associated with decreased sensitivity to estradiol negative feedback that underlies reproductive maturation. Ewe lambs were ovariectomized at approximately 24 wk of age and received no implant (OVX; n=7) or received a subcutaneous implant containing estradiol (OVX+E; n=14). At 30 wk of age, blood samples were collected to characterize the pattern of luteinizing hormone (LH) secretion. Lambs were then euthanized and a block of tissue containing the preoptic area (POA) and hypothalamus was collected. Detection of ESR1 mRNA and kisspeptin was performed by dual-label in situ hybridization/immunocytochemistry. The abundance of ESR1 mRNA in the middle arcuate nucleus (mARC) was greater in OVX than in OVX+E ewe lambs but did not differ between groups in any other hypothalamic area investigated. Posthoc analysis of the LH data obtained from OVX+E lambs indicated three distinct patterns of LH release: low (1-2 pulses/12 h; n=3), moderate (6-7 pulses/12 h; n=6) and high (>10 pulses/12 h; n=5) frequency of LH pulses. The proportion of kisspeptin cells containing ESR1 mRNA in the POA/periventricular area did not differ among OVX+E lambs exhibiting low, moderate and high frequency of LH pulses. However, the proportion of kisspeptin cells containing ESR1 mRNA in the mid ARC was greater in OVX+E lambs exhibiting high frequency of LH pulses (0.57) than in lambs exhibiting moderate (0.36) or low (0.27) LH pulsatility, and did not differ from OVX (0.50) lambs. Contrary to our hypothesis, the increase in LH pulsatility in maturing ewe lambs is associated with enhanced ESR1 expression in kisspeptin neurons in the ARC. This indicates that the mechanism of decreased sensitivity to estradiol negative feedback during maturation of the reproductive neuroendocrine axis does not involve limiting ESR1 transcription in kisspeptin neurons.
Advisors/Committee Members: Amstalden, Marcel (advisor), Sohrabji, Farida (committee member), Williams, Gary L (committee member).
Subjects/Keywords: Neuroendocrinology; Kisspeptin; ESR1; Sheep; Puberty
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bedenbaugh, M. N. (2014). Regulation of ESR1 in Kisspeptin Neurons during Reproductive Maturation in Ewe Lambs. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153860
Chicago Manual of Style (16th Edition):
Bedenbaugh, Michelle Nichole. “Regulation of ESR1 in Kisspeptin Neurons during Reproductive Maturation in Ewe Lambs.” 2014. Masters Thesis, Texas A&M University. Accessed April 10, 2021.
http://hdl.handle.net/1969.1/153860.
MLA Handbook (7th Edition):
Bedenbaugh, Michelle Nichole. “Regulation of ESR1 in Kisspeptin Neurons during Reproductive Maturation in Ewe Lambs.” 2014. Web. 10 Apr 2021.
Vancouver:
Bedenbaugh MN. Regulation of ESR1 in Kisspeptin Neurons during Reproductive Maturation in Ewe Lambs. [Internet] [Masters thesis]. Texas A&M University; 2014. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1969.1/153860.
Council of Science Editors:
Bedenbaugh MN. Regulation of ESR1 in Kisspeptin Neurons during Reproductive Maturation in Ewe Lambs. [Masters Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153860

Penn State University
5.
Motta-Mena, Natalie.
Developing Sensitivity to Complex Facial Expressions in Adolescence
.
Degree: 2014, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/23615
► The ability to produce and interpret facial expressions enables humans to communicate vital information in reciprocal social exchanges. In the first years of life, human…
(more)
▼ The ability to produce and interpret facial expressions enables humans to communicate vital information in reciprocal social exchanges. In the first years of life, human infants begin to develop the ability to perceive and categorize basic emotional expressions (e.g. happy, sad, angry); however, these abilities continue to improve throughout childhood and into adolescence. Interestingly, very little is known about the developmental trajectory of sensitivity to more socially complex emotional expressions such as resentment, envy, or contempt. Importantly, the research that does exist has been conducted almost exclusively in atypical populations. In this project, we hypothesized that adolescence would be a key period for the emergence of sensitivity to socially complex expressions, largely because a subset of these expressions tend to provide signals about the status of more intimate relationships (i.e., with sexual and romantic partners and/or competitors) that adolescents are only beginning to form with their peers. We also hypothesized that sensitivity to these complex expressions would be fundamentally related to pubertal maturation, which likely influences the motivation to form more intimate, romantic, and sexual relationships in adolescence. To evaluate these hypotheses, we conducted two experiments to measure developmental changes in perceptual sensitivity to detect both basic (e.g., happy) and complex emotional expressions in four groups: pre-pubescent children (ages 6-8), adolescents in early versus later stages of pubertal development (ages 11-14), and sexually mature adults (ages 20-25). We report several age-related changes from childhood to adulthood as well as
puberty-related changes in the absence of age-related changes from early pubertal development to late pubertal development.
Advisors/Committee Members: Kathyrn Suzanne Scherf, Thesis Advisor/Co-Advisor.
Subjects/Keywords: Adolescence; puberty; facial expressions
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Motta-Mena, N. (2014). Developing Sensitivity to Complex Facial Expressions in Adolescence
. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/23615
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Motta-Mena, Natalie. “Developing Sensitivity to Complex Facial Expressions in Adolescence
.” 2014. Thesis, Penn State University. Accessed April 10, 2021.
https://submit-etda.libraries.psu.edu/catalog/23615.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Motta-Mena, Natalie. “Developing Sensitivity to Complex Facial Expressions in Adolescence
.” 2014. Web. 10 Apr 2021.
Vancouver:
Motta-Mena N. Developing Sensitivity to Complex Facial Expressions in Adolescence
. [Internet] [Thesis]. Penn State University; 2014. [cited 2021 Apr 10].
Available from: https://submit-etda.libraries.psu.edu/catalog/23615.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Motta-Mena N. Developing Sensitivity to Complex Facial Expressions in Adolescence
. [Thesis]. Penn State University; 2014. Available from: https://submit-etda.libraries.psu.edu/catalog/23615
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University
6.
Marceau, Kristine P.
Pubertal Maturation as a Moderator of Genetic and Environmental Influences on Internalizing Behavior
.
Degree: 2011, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/11641
► Pubertal development is a socially salient, physiological process that may impact concurrent internalizing problems via physiological, genetic and/or environmental pathways. The present study uses two…
(more)
▼ Pubertal development is a socially salient, physiological process that may impact concurrent internalizing problems via physiological, genetic and/or environmental pathways. The present study uses two genetically informed samples to examine (1) sex differences in genetic and environmental influences on internalizing behavior, and (2) the moderating effects of pubertal maturation, and a subset of items indexing gonadal maturation, on genetic and environmental influences on internalizing behavior in boys and girls during adolescence. Genetic and environmental influences on internalizing behavior differed for boys and girls in both samples. Total pubertal maturation moderated genetic and environmental influences on internalizing behavior for girls in one sample, such that genetic influences accounted for more of the variance in internalizing behavior among pre-pubertal girls than pubertal girls but shared and nonshared environmental influences accounted for more of the variance in internalizing behavior among pubertal girls than pre-pubertal girls. Gonadal maturation marginally moderated genetic influences on internalizing behavior for girls in the other sample such that genetic influences accounted for more variance in internalizing behavior among pubertal girls than pre-pubertal girls. Pubertal maturation did not moderate genetic and environmental influences on internalizing behavior for boys. In sum, results suggest multiple pathways for the influence of pubertal maturation on genetic and environmental influences on internalizing behavior in girls depending on the index of pubertal maturation.
Advisors/Committee Members: Jenae Marie Neiderhiser, Dissertation Advisor/Co-Advisor, Jenae Marie Neiderhiser, Thesis Advisor/Co-Advisor.
Subjects/Keywords: Puberty; Quantitative Genetics; Internalizing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Marceau, K. P. (2011). Pubertal Maturation as a Moderator of Genetic and Environmental Influences on Internalizing Behavior
. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/11641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Marceau, Kristine P. “Pubertal Maturation as a Moderator of Genetic and Environmental Influences on Internalizing Behavior
.” 2011. Thesis, Penn State University. Accessed April 10, 2021.
https://submit-etda.libraries.psu.edu/catalog/11641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Marceau, Kristine P. “Pubertal Maturation as a Moderator of Genetic and Environmental Influences on Internalizing Behavior
.” 2011. Web. 10 Apr 2021.
Vancouver:
Marceau KP. Pubertal Maturation as a Moderator of Genetic and Environmental Influences on Internalizing Behavior
. [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Apr 10].
Available from: https://submit-etda.libraries.psu.edu/catalog/11641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Marceau KP. Pubertal Maturation as a Moderator of Genetic and Environmental Influences on Internalizing Behavior
. [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/11641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph
7.
Giffin, Jennifer L.
Determinants of Testicular Echotexture in the Sexually Immature Ram Lamb.
Degree: PhD, Department of Biomedical Sciences, 2015, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8662
► Throughout sexual maturation, dynamic changes in testicular macro- and microstructure and reproductive hormone levels occur. Future adult reproductive capability is critically dependent on these changes;…
(more)
▼ Throughout sexual maturation, dynamic changes in testicular macro- and microstructure and reproductive hormone levels occur. Future adult reproductive capability is critically dependent on these changes; therefore, regular monitoring of pubertal testicular development is desirable. However, conventional methods of assessment do not permit the frequent and non-invasive examination of testicular function. Recently, scrotal ultrasonography in conjunction with computer-assisted image analysis has emerged as a potential non-invasive alternative for male reproductive assessment. In this procedure, testicular echotexture, or the appearance of the ultrasonogram, is objectively quantified on the basis of brightness or intensity of the minute picture elements, or pixels, comprising the image. In general, testicular pixel intensity increases with age throughout sexual maturation; however, periodic fluctuations occur. Changes in testicular echotexture are related to microstructural attributes of the testes and reproductive hormone secretion, but reports on these relationships have been inconsistent. Therefore, the overall objective of the studies presented in this thesis was to investigate how testicular echotexture and its associations with testicular histomorphology and endocrine profiles may be influenced by various factors including: i) scrotal/testicular integument; ii) blood flow/content; iii) stage of development; and iv) altered spermatogenic onset. Serial scrotal ultrasonograms, testicular biopsies or castrations and blood samples were collected from early postnatal or peripubescent ram lambs and analyzed to obtain echotextural, histomorphological and endocrine data, respectively. Testicular echotextural attributes were influenced by the presence of the scrotal and testicular integument, the stage of spermatogenic development (mitotic vs. post-mitotic) and the amount of germ cell heterogeneity present with or without retinoic acid exposure, but not by blood flow or content. Tubular and luminal size of the seminiferous tubules could be predicted from testicular pixel intensity using a simple linear regression model and demonstrated a moderate strength correlation with testicular echotextural parameters, as did a number of cellular and sub-cellular histomorphological attributes and reproductive hormone levels. These results clearly demonstrate the ability of testicular echotexture to detect experimentally and clinically relevant markers of testicular function. Computerized image analysis of scrotal ultrasonograms holds promise as a non-invasive diagnostic and prognostic tool and novel monitoring device of testicular histophysiology.
Advisors/Committee Members: Bartlewski, Pawel M. (advisor).
Subjects/Keywords: testis; ultrasound; puberty; spermatogenesis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Giffin, J. L. (2015). Determinants of Testicular Echotexture in the Sexually Immature Ram Lamb. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8662
Chicago Manual of Style (16th Edition):
Giffin, Jennifer L. “Determinants of Testicular Echotexture in the Sexually Immature Ram Lamb.” 2015. Doctoral Dissertation, University of Guelph. Accessed April 10, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8662.
MLA Handbook (7th Edition):
Giffin, Jennifer L. “Determinants of Testicular Echotexture in the Sexually Immature Ram Lamb.” 2015. Web. 10 Apr 2021.
Vancouver:
Giffin JL. Determinants of Testicular Echotexture in the Sexually Immature Ram Lamb. [Internet] [Doctoral dissertation]. University of Guelph; 2015. [cited 2021 Apr 10].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8662.
Council of Science Editors:
Giffin JL. Determinants of Testicular Echotexture in the Sexually Immature Ram Lamb. [Doctoral Dissertation]. University of Guelph; 2015. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8662

University of Otago
8.
Agnew, Carole.
The Discursive Construction of Menstruation within Puberty Education
.
Degree: 2012, University of Otago
URL: http://hdl.handle.net/10523/2476
► Menstruation is a significant milestone in a woman’s life, signifying the onset of puberty and the journey into womanhood. Yet research suggests that the construction…
(more)
▼ Menstruation is a significant milestone in a woman’s life, signifying the onset of
puberty and the journey into womanhood. Yet research suggests that the construction of menstruation has many women feeling uncertain and negative about menstruation, and what it means for them. Within the research literature I found four dominant discourses that construct our understandings of menstruation; menstruation as a hygiene crisis that needs rigid management, menstruation as a shameful secret that must be concealed, menstruation as biological and medical where the purpose of menstruation is restricted to pregnancy or illness, and menstruation as constitutive of womanhood in terms of motherhood, and femininity.
My review of the research literature led me to design a project to examine the ways menstruation is currently constructed within
puberty education, with a particular interest in the various discourses presented to young women. I look at how the girls take up and/or resist these discourses as well as look at the subjectivities made available from them. Finally I examine the ways a wider variety of discourses can be made available and in turn a greater range of subjectivities.
As a feminist poststructuralist, I am looking specifically at issues of gender and sexuality, and how meaning and knowledge is constructed through language and discourse. With this as my theoretical framework, I observed three lessons, each teacher’s specific lesson on menstruation, and a concluding joint girl-only lesson, within a
puberty unit of a New Zealand intermediate school, conducted individual interviews with the two teachers and focus group the interviews provide the data of this research.
Using a discourse analysis approach to examine my data I was able to show the four dominant discourses were still present in the teaching of menstruation at the study school. I also found three discourses that, although not new, appear to be under examined within the construction of menstruation. These discourses of dread, consumerism and celebration may contribute to the dominant constructions of menstruation and/or offer ways to challenge and subvert these constructions. By making visible these discourses and the ways they construct menstruation, I am not looking to locate the ‘correct’ way to teach or understand menstruation. However, I argue that by supporting young women and their teachers to critically analyse the various discourses that shape our understandings of menstruation, we may create opportunities to challenge and resist the dominant constructions as well as open up a wider range of subjectivities.
Advisors/Committee Members: Sandretto, Susan (advisor).
Subjects/Keywords: puberty;
menstruation;
gender;
poststructuralism
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APA (6th Edition):
Agnew, C. (2012). The Discursive Construction of Menstruation within Puberty Education
. (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/2476
Chicago Manual of Style (16th Edition):
Agnew, Carole. “The Discursive Construction of Menstruation within Puberty Education
.” 2012. Masters Thesis, University of Otago. Accessed April 10, 2021.
http://hdl.handle.net/10523/2476.
MLA Handbook (7th Edition):
Agnew, Carole. “The Discursive Construction of Menstruation within Puberty Education
.” 2012. Web. 10 Apr 2021.
Vancouver:
Agnew C. The Discursive Construction of Menstruation within Puberty Education
. [Internet] [Masters thesis]. University of Otago; 2012. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10523/2476.
Council of Science Editors:
Agnew C. The Discursive Construction of Menstruation within Puberty Education
. [Masters Thesis]. University of Otago; 2012. Available from: http://hdl.handle.net/10523/2476
9.
Mul, Dick.
Treatment of early puberty in adopted and non-adopted children: when, why and how: Auxological, psychological and ethical aspects of growth promoting treatment around puberty.
Degree: 2000, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/20394
► textabstractNormal puberty is the result of the maturation of the hypothalamo-pituitary-gonadal (HPG) axis. Primary and secondary sexual characteristics develop by the increase in the serum…
(more)
▼ textabstractNormal puberty is the result of the maturation of the hypothalamo-pituitary-gonadal (HPG)
axis. Primary and secondary sexual characteristics develop by the increase in the serum
levels of gonadal steroids: oestradiol in girls and testosterone in boys.
The main players in the process of normal puberty are the hypothalamus, by
producing pulsatile Gonadotrophin Releasing Hormone (GnRH), and the pituitary. GnRH
influences the pituitary via the portal vein system and the pituitary secretes the
gonadotrophins Luteinizing Hormone and Follicle Stimulating Hormone (LH and FSH). LH
and FSH in turn stimulate the gonads to develop the cells essential for reproduction and to
secrete the gonadal steroids.
In girls this maturational process primarily leads to the development of the breasts and
internal genitalia. Menarche follows as a result of ongoing maturation. In boys it results in
growth of the testes, pubic and axillary hair, lowering of the voice and spermarche. In both
sexes, a pubertal growth spurt occurs as well as further psychosocial and psychosexual
development.
Subjects/Keywords: endocrinology; puberty
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mul, D. (2000). Treatment of early puberty in adopted and non-adopted children: when, why and how: Auxological, psychological and ethical aspects of growth promoting treatment around puberty. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/20394
Chicago Manual of Style (16th Edition):
Mul, Dick. “Treatment of early puberty in adopted and non-adopted children: when, why and how: Auxological, psychological and ethical aspects of growth promoting treatment around puberty.” 2000. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 10, 2021.
http://hdl.handle.net/1765/20394.
MLA Handbook (7th Edition):
Mul, Dick. “Treatment of early puberty in adopted and non-adopted children: when, why and how: Auxological, psychological and ethical aspects of growth promoting treatment around puberty.” 2000. Web. 10 Apr 2021.
Vancouver:
Mul D. Treatment of early puberty in adopted and non-adopted children: when, why and how: Auxological, psychological and ethical aspects of growth promoting treatment around puberty. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2000. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1765/20394.
Council of Science Editors:
Mul D. Treatment of early puberty in adopted and non-adopted children: when, why and how: Auxological, psychological and ethical aspects of growth promoting treatment around puberty. [Doctoral Dissertation]. Erasmus University Medical Center; 2000. Available from: http://hdl.handle.net/1765/20394

University of Cape Town
10.
Largier, Damian Douglas Christopher.
Pubertal development in urban Xhosa schoolgirls.
Degree: Image, Obstetrics and Gynaecology, 1995, University of Cape Town
URL: http://hdl.handle.net/11427/26625
► The present study was performed in order to update available data on puberty in South African women gathered from studies among a variety of South…
(more)
▼ The present study was performed in order to update available data on
puberty in South African women gathered from studies among a variety of South African population groups and to compare our findings with these previous studies in order to identify any change. In addition, the children's social environment was evaluated to see if it had any influence on the timing of
puberty. This study is important because a decrease in the age of onset of the various stages of
puberty would be expected as the socio-economic status of the population increases. We would expect that once socio-economic and therefore nutritional equality between different communities exists, there would be little difference between the age at which children attain
puberty. An absence in the trend toward a younger onset of
puberty would be a cause for concern as this would imply that there has been no improvement in living conditions from the time of the original study. A relationship has also been shown to exist between an earlier age at menarche and an increased risk of breast cancer (Pike 1983), an increased risk of coronary heart disease (Colditz 1987), shorter adult height (Shangold 1989), earlier initiation of sexual activity (Soefer 1985), earlier first pregnancy, (Sandler 1984) and larger family size (Frisch 1978). This implies that as the age at which children pass through
puberty decreases, it becomes increasingly important to introduce both sexual education and the availability of contraception at a correspondingly earlier age in order to avoid the tragedies of teenage pregnancies.
Advisors/Committee Members: van der Spuy, Zephne Margaret (advisor).
Subjects/Keywords: Menarche; Puberty
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Largier, D. D. C. (1995). Pubertal development in urban Xhosa schoolgirls. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/26625
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Largier, Damian Douglas Christopher. “Pubertal development in urban Xhosa schoolgirls.” 1995. Thesis, University of Cape Town. Accessed April 10, 2021.
http://hdl.handle.net/11427/26625.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Largier, Damian Douglas Christopher. “Pubertal development in urban Xhosa schoolgirls.” 1995. Web. 10 Apr 2021.
Vancouver:
Largier DDC. Pubertal development in urban Xhosa schoolgirls. [Internet] [Thesis]. University of Cape Town; 1995. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/11427/26625.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Largier DDC. Pubertal development in urban Xhosa schoolgirls. [Thesis]. University of Cape Town; 1995. Available from: http://hdl.handle.net/11427/26625
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign
11.
Haraden, Dustin.
The relationship between depression and chronotype: A longitudinal assessment during childhood and adolescence.
Degree: MS, Psychology, 2017, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/99534
► Background/Objective During adolescence, chronotype shifts towards “eveningness.” “Eveningness” is related to negative physical and mental health outcomes. Little is known about what influences the shift…
(more)
▼ Background/Objective
During adolescence, chronotype shifts towards “eveningness.” “Eveningness” is related to negative physical and mental health outcomes. Little is known about what influences the shift in chronotype beyond pubertal status. The current study examined the influence of earlier depression predicting later individual differences in adolescent chronotype, accounting for pubertal status, and the prospective prediction of later increases in depression from earlier chronotype.
Methods
Youth (age M=12.06, SD=2.35; 56.5% girls) from the community completed repeated assessments of depression, including both self-reports (14 assessments) and diagnostic interviews (8 assessments), over a 48-month period. At the 36-month time-point, participants completed chronotype and pubertal development measures. Regression and ANOVA analyses examined: (1) the influence of earlier depression levels (baseline to 36-months) upon chronotype, and (2) chronotype (at 36 months) upon later depression (48 months).
Results
Youth with higher earlier depression symptoms (β=-.347, p<.001) and history of depression diagnosis (β=-.13, p=.045) showed a greater eveningness preference controlling for pubertal status, age and gender. Further, depression diagnosis history interacted with pubertal status to predict chronotype: (F(1,243)=4.171, p=.045) such that the influence of depression on chronotype was greatest among postpubertal youth (t=3.271, p=.002). Chronotype (greater eveningness preference) predicted prospective increases in depression symptoms (β=-.16, p=.03) and onset of depressive episode (b=-.085, OR=.92, p=.03) one year later.
Conclusion
Depression, experienced earlier in life, predicts greater preference for eveningness, especially among postpubertal youth. In turn, later depression is predicted by evening preference. These findings suggest the reciprocal interplay between mood and biological rhythms, especially depression and chronotype, during adolescence.
Advisors/Committee Members: Hankin, Benjamin L. (advisor).
Subjects/Keywords: chronotype; circadian; youth; depression; puberty
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Haraden, D. (2017). The relationship between depression and chronotype: A longitudinal assessment during childhood and adolescence. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/99534
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Haraden, Dustin. “The relationship between depression and chronotype: A longitudinal assessment during childhood and adolescence.” 2017. Thesis, University of Illinois – Urbana-Champaign. Accessed April 10, 2021.
http://hdl.handle.net/2142/99534.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Haraden, Dustin. “The relationship between depression and chronotype: A longitudinal assessment during childhood and adolescence.” 2017. Web. 10 Apr 2021.
Vancouver:
Haraden D. The relationship between depression and chronotype: A longitudinal assessment during childhood and adolescence. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2017. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/2142/99534.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Haraden D. The relationship between depression and chronotype: A longitudinal assessment during childhood and adolescence. [Thesis]. University of Illinois – Urbana-Champaign; 2017. Available from: http://hdl.handle.net/2142/99534
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech
12.
McCracken, Victoria Lorraine.
The Effects of Dietary Fructose and Fat on the Reproductive Parameters of Prepubertal and Pregnant Gilts.
Degree: MS, Animal and Poultry Sciences, 2015, Virginia Tech
URL: http://hdl.handle.net/10919/73209
► Body adiposity is generally considered the most pertinent factor in puberty attainment; however, recent data suggests that pre-pubertal reproductive tract development may be altered by…
(more)
▼ Body adiposity is generally considered the most pertinent factor in
puberty attainment; however, recent data suggests that pre-pubertal reproductive tract development may be altered by dietary sugar consumption. Two experiments were conducted to delineate the direct effects of fructose on the maturation of the pre-pubertal reproductive tract and fertility. At three weeks of age, forty gilts were placed on one of five dietary treatments (n=8) containing 15% fat (FAT), 35% fructose (FRU), both fat and fructose (HFHF), or two different controls: one standard industry (IND) diet meant to result in optimal lean growth and a second diet to account for the reduced lysine (LYS) intake in the treatment diets. Body weights did not differ amongst any of the five treatments on the day of sacrifice (P=0.32). As a percentage of BW, total reproductive tracts were heavier in fructose fed gilts (1.3±0.1 v. 0.8±0.1%; P=0.01) compared to non-fructose gilts. In the second experiment, starting at 130d of age, gilts were checked twice daily for
puberty attainment. Gilts that attained
puberty were artificially inseminated (AI) on their third estrous cycle. On gestational day 38±3, pregnant gilts were harvested for reproductive tract collection. Fewer fructose fed (FRU and HFHF) pigs became pregnant than non-fructose fed (IND, LYS, and FAT) gilts (25% v. 75% respectively; P=0.03). All HFHF gilts failed to become pregnant. Placental weights were greater in LYS fetuses than FAT fetuses (79.07 ± 6.55g v. 47.26 ± 6.45g, respectively, P= 0.04). Taken together, these results demonstrate that fructose consumption increases reproductive tract size, but that reproductive capabilities are reduced.
Advisors/Committee Members: Rhoads, Michelle (committeechair), Ealy, Alan D. (committee member), Scheffler, Jason M. (committee member), El-Kadi, Samer Wassim (committee member).
Subjects/Keywords: fructose; adiposity; puberty; gilts; pregnancy
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McCracken, V. L. (2015). The Effects of Dietary Fructose and Fat on the Reproductive Parameters of Prepubertal and Pregnant Gilts. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/73209
Chicago Manual of Style (16th Edition):
McCracken, Victoria Lorraine. “The Effects of Dietary Fructose and Fat on the Reproductive Parameters of Prepubertal and Pregnant Gilts.” 2015. Masters Thesis, Virginia Tech. Accessed April 10, 2021.
http://hdl.handle.net/10919/73209.
MLA Handbook (7th Edition):
McCracken, Victoria Lorraine. “The Effects of Dietary Fructose and Fat on the Reproductive Parameters of Prepubertal and Pregnant Gilts.” 2015. Web. 10 Apr 2021.
Vancouver:
McCracken VL. The Effects of Dietary Fructose and Fat on the Reproductive Parameters of Prepubertal and Pregnant Gilts. [Internet] [Masters thesis]. Virginia Tech; 2015. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10919/73209.
Council of Science Editors:
McCracken VL. The Effects of Dietary Fructose and Fat on the Reproductive Parameters of Prepubertal and Pregnant Gilts. [Masters Thesis]. Virginia Tech; 2015. Available from: http://hdl.handle.net/10919/73209
13.
Howard, Sasha.
Investigation of the genetic regulation of delayed puberty.
Degree: PhD, 2017, Queen Mary, University of London
URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/28165
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765963
► The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse…
(more)
▼ The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes. Self-limited delayed puberty (DP) segregates in an autosomal dominant pattern and is highly heritable; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes. Self-limited delayed puberty (DP) segregates in an autosomal dominant pattern and is highly heritable; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. Our large, accurately phenotyped cohort of patients with familial self-limited DP is a unique resource with a relatively homogeneous genetic composition. I have utilised this cohort to investigate the genetic variants segregating with the DP trait in these pedigrees. Whole exome sequencing in eighteen probands and their relatives, and subsequent targeted sequencing in an extended subgroup of the cohort, has revealed potential novel genetic regulators of pubertal timing. In ten unrelated probands, I identified rare mutations in IGSF10, a gene that is strongly expressed in the nasal mesenchyme during embryonic migration of gonadotropin-releasing hormone (GnRH) neurons. IGSF10 knockdown both in vitro and in a transgenic zebrafish model resulted in perturbed GnRH neuronal migration. Loss-of-function mutations in IGSF10 were also identified in five patients with absent puberty due to hypogonadotropic hypogonadism (HH). Additionally, I have identified and investigated one rare, pathogenic mutation in HS6ST1 - a gene known to cause HH - in one family with DP, and two rare variants in FTO - a gene implicated in the timing of menarche in the general population - in 3 families. Further potentially pathogenic variants have emerged from investigating candidate genes identified from microarray studies (LGR4, SEMA6A and NEGR1) and from related clinical phenotypes (IGSF1). Our large, accurately phenotyped cohort of patients with familial self-limited DP is a unique resource with a relatively homogeneous genetic composition. I have utilised this cohort to investigate the genetic variants segregating with the DP trait in these pedigrees. Whole exome sequencing in eighteen probands and their relatives, and subsequent targeted sequencing in an extended subgroup of the cohort, has revealed potential novel genetic regulators of pubertal timing. In ten unrelated probands, I identified rare mutations in IGSF10, a gene that is strongly expressed in the nasal mesenchyme during embryonic migration of gonadotropin-releasing hormone (GnRH) neurons. IGSF10 knockdown both in vitro and in a transgenic zebrafish model resulted in perturbed GnRH neuronal migration. Loss-of-function mutations in IGSF10 were also identified in five patients with absent puberty due to hypogonadotropic hypogonadism (HH). Additionally, I have…
Subjects/Keywords: 612.6; Endocrinology; delayed puberty
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Howard, S. (2017). Investigation of the genetic regulation of delayed puberty. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/28165 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765963
Chicago Manual of Style (16th Edition):
Howard, Sasha. “Investigation of the genetic regulation of delayed puberty.” 2017. Doctoral Dissertation, Queen Mary, University of London. Accessed April 10, 2021.
http://qmro.qmul.ac.uk/xmlui/handle/123456789/28165 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765963.
MLA Handbook (7th Edition):
Howard, Sasha. “Investigation of the genetic regulation of delayed puberty.” 2017. Web. 10 Apr 2021.
Vancouver:
Howard S. Investigation of the genetic regulation of delayed puberty. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2017. [cited 2021 Apr 10].
Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/28165 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765963.
Council of Science Editors:
Howard S. Investigation of the genetic regulation of delayed puberty. [Doctoral Dissertation]. Queen Mary, University of London; 2017. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/28165 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765963

University of Cambridge
14.
Hollis, Benjamin.
Early life determinants of metabolic and reproductive health.
Degree: PhD, 2019, University of Cambridge
URL: https://doi.org/10.17863/CAM.62304
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.821534
► Events in early life have consistently been associated with health outcomes in later life. The ‘developmental origins’ theory first hypothesised that adverse conditions in-utero can…
(more)
▼ Events in early life have consistently been associated with health outcomes in later life. The ‘developmental origins’ theory first hypothesised that adverse conditions in-utero can lead to physiological adaptations in the developing foetus which have long lasting influences on health. This concept has been extended to early childhood and adolescence, whereby exposures during critical periods of development can impact health throughout the life course of an individual. In particular, a secular trend for a decreasing age of puberty onset has been linked to the global increases in prevalence of cardio-metabolic diseases and cancer. It has been suggested that childhood obesity and lifetime sex hormone exposure may act as key mediating factors in this relationship. As the prevalence of obesity continues to rise globally and consequent comorbidities place an increasing burden on healthcare systems, understanding the mechanisms that link early life events to later life health have become of increasing importance. While environmental exposures are often cited as being highly influential on growth and development, the role of genetics has become gradually more apparent in recent years. This has been aided by the availability of increasingly large data resources. Genetic studies have shown that many developmental traits are highly heritable and share genetic determinants with metabolic and reproductive health outcomes. In this thesis I use data from large-scale, population-based resources to further elucidate the role of genetic and epigenetic factors in explaining observed associations between developmental traits and later life metabolic and reproductive health. I begin by examining the genetic aetiology of puberty timing in men, a key stage of sexual development which is understudied compared to women. I identify 29 novel genes involved in the control of puberty timing, implicating new biological pathways and demonstrate genetic correlations between earlier age of puberty and adverse health in adulthood. I then expand on the theme of genetic discovery by conducting genome-wide association studies (GWAS) for reproductive traits in the UK Biobank study. These outcomes have important societal and public health impacts but many have not previously been investigated from a genetic perspective. I identify over 800 variant-trait associations, highlighting genomic regions with highly pleiotropic influences on a diverse range of reproductive traits. This data is then leveraged to construct a framework for conducting phenome-wide association studies (PheWAS), which is used to explore the extent to which both BMI and sex hormone exposure act as mediating factors to explain the link between earlier puberty and heightened reproductive health risks. I go on to examine mechanisms linking early life markers of development to adult health. I investigate the association between weight at birth and body composition in adulthood, determining that foetal and maternal-specific genetic determinants of birth weight have differential influences on…
Subjects/Keywords: Genetics; Epidemiology; Growth; Development; Puberty
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hollis, B. (2019). Early life determinants of metabolic and reproductive health. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.62304 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.821534
Chicago Manual of Style (16th Edition):
Hollis, Benjamin. “Early life determinants of metabolic and reproductive health.” 2019. Doctoral Dissertation, University of Cambridge. Accessed April 10, 2021.
https://doi.org/10.17863/CAM.62304 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.821534.
MLA Handbook (7th Edition):
Hollis, Benjamin. “Early life determinants of metabolic and reproductive health.” 2019. Web. 10 Apr 2021.
Vancouver:
Hollis B. Early life determinants of metabolic and reproductive health. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Apr 10].
Available from: https://doi.org/10.17863/CAM.62304 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.821534.
Council of Science Editors:
Hollis B. Early life determinants of metabolic and reproductive health. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://doi.org/10.17863/CAM.62304 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.821534

Rutgers University
15.
Szamreta, Elizabeth A., 1987-.
Consumption of a Mediterranean-like diet and its relationship with growth, body fatness, and puberty.
Degree: PhD, Public Health, 2018, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59242/
► In recent years, there has been a population-level trend toward earlier puberty, which presents psychological and clinical risks to girls. Body fatness and earlier puberty…
(more)
▼ In recent years, there has been a population-level trend toward earlier
puberty, which presents psychological and clinical risks to girls. Body fatness and earlier
puberty are also risk factors for problems including adult obesity and breast cancer. Diet is a primary and modifiable factor that can influence
puberty and growth. Current research on a Mediterranean-like dietary pattern in regard to these outcomes is limited; no studies have examined its role in
puberty outcomes or longitudinal growth, and only one study has examined a Mediterranean-like diet (MD) and body mass index (BMI) in a healthy U.S. pediatric population. We aimed to address these gaps in the literature by evaluating the role of MD adherence in
puberty, growth, and body fatness in The Jersey Girl Study. We developed an index for assessing adherence to a Mediterranean-like diet and evaluated its relationship with cross-sectional and longitudinal outcomes. Our sample was a cohort of 202 girls who resided in New Jersey and were 9 or 10 years old at baseline. Data were collected from a baseline study visit and physical examination, a 3-day dietary recall, a general baseline questionnaire filled out by girls’ mothers, and annual follow-up questionnaires on growth and
puberty outcomes.
Multivariable Poisson regression models showed that high adherence (score 6-9) was significantly associated with lower prevalence of thelarche at baseline compared to girls with low adherence (score 0-3) (Prevalence Ratio: 0.65, 95% confidence interval (CI): 0.48-0.90 in the fully adjusted model). Further analysis suggested that this may have been driven by consumption of fish and reduced/low/non-fat dairy. Multivariable linear regression models to examine mean age at thelarche also suggested a nonsignificant trend of later age at thelarche with higher MD adherence. Multivariable Cox proportional hazards models found that girls with higher MD adherence had significantly longer time to menarche (Hazard Ratio: 0.45, 95% CI: 0.28-0.71 in the fully adjusted model for girls with high vs. low MD adherence). Further analysis suggested that this relationship was driven by vegetable and reduced/low/non-fat dairy consumption. Multivariable proportional odds models for being overweight or obese at baseline, and multivariable linear regression models comparing mean BMI z-score, percent body fat, waist circumference, waist-to-hip ratio, waist-to-height ratio, height at baseline, and height at menarche, did not show a significant relationship with MD adherence in this study. Multivariable linear mixed-effects growth models also did not show a difference in pubertal growth rate based on MD adherence.
The results of our study were consistent with previous findings that certain components of a Mediterranean-like diet were associated with a later age at menarche and thelarche. To our knowledge, this is the first study to demonstrate an association between an overall MD pattern and
puberty outcomes. Our results suggest that consuming a more Mediterranean-like diet (high in plant-based…
Advisors/Committee Members: Bandera, Elisa V (chair), Barrett, Emily S (internal member), LIN, YONG (internal member), Parekh, Niyati (outside member), School of Graduate Studies.
Subjects/Keywords: Puberty; Preteen girls; Diet
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APA ·
Chicago ·
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APA (6th Edition):
Szamreta, Elizabeth A., 1. (2018). Consumption of a Mediterranean-like diet and its relationship with growth, body fatness, and puberty. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59242/
Chicago Manual of Style (16th Edition):
Szamreta, Elizabeth A., 1987-. “Consumption of a Mediterranean-like diet and its relationship with growth, body fatness, and puberty.” 2018. Doctoral Dissertation, Rutgers University. Accessed April 10, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/59242/.
MLA Handbook (7th Edition):
Szamreta, Elizabeth A., 1987-. “Consumption of a Mediterranean-like diet and its relationship with growth, body fatness, and puberty.” 2018. Web. 10 Apr 2021.
Vancouver:
Szamreta, Elizabeth A. 1. Consumption of a Mediterranean-like diet and its relationship with growth, body fatness, and puberty. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Apr 10].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59242/.
Council of Science Editors:
Szamreta, Elizabeth A. 1. Consumption of a Mediterranean-like diet and its relationship with growth, body fatness, and puberty. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59242/

University of Cambridge
16.
Hollis, Benjamin.
Early Life Determinants of Metabolic and Reproductive Health.
Degree: PhD, 2019, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/315196
► Events in early life have consistently been associated with health outcomes in later life. The ‘developmental origins’ theory first hypothesised that adverse conditions in-utero can…
(more)
▼ Events in early life have consistently been associated with health outcomes in later life. The ‘developmental origins’ theory first hypothesised that adverse conditions in-utero can lead to physiological adaptations in the developing foetus which have long lasting influences on health. This concept has been extended to early childhood and adolescence, whereby exposures during critical periods of development can impact health throughout the life course of an individual. In particular, a secular trend for a decreasing age of puberty onset has been linked to the global increases in prevalence of cardio-metabolic diseases and cancer. It has been suggested that childhood obesity and lifetime sex hormone exposure may act as key mediating factors in this relationship. As the prevalence of obesity continues to rise globally and consequent comorbidities place an increasing burden on healthcare systems, understanding the mechanisms that link early life events to later life health have become of increasing importance. While environmental exposures are often cited as being highly influential on growth and development, the role of genetics has become gradually more apparent in recent years. This has been aided by the availability of increasingly large data resources. Genetic studies have shown that many developmental traits are highly heritable and share genetic determinants with metabolic and reproductive health outcomes. In this thesis I use data from large-scale, population-based resources to further elucidate the role of genetic and epigenetic factors in explaining observed associations between developmental traits and later life metabolic and reproductive health. I begin by examining the genetic aetiology of puberty timing in men, a key stage of sexual development which is understudied compared to women. I identify 29 novel genes involved in the control of puberty timing, implicating new biological pathways and demonstrate genetic correlations between earlier age of puberty and adverse health in adulthood. I then expand on the theme of genetic discovery by conducting genome-wide association studies (GWAS) for reproductive traits in the UK Biobank study. These outcomes have important societal and public health impacts but many have not previously been investigated from a genetic perspective. I identify over 800 variant-trait associations, highlighting genomic regions with highly pleiotropic influences on a diverse range of reproductive traits. This data is then leveraged to construct a framework for conducting phenome-wide association studies (PheWAS), which is used to explore the extent to which both BMI and sex hormone exposure act as mediating factors to explain the link between earlier puberty and heightened reproductive health risks. I go on to examine mechanisms linking early life markers of development to adult health. I investigate the association between weight at birth and body composition in adulthood, determining that foetal and maternal-specific genetic determinants of birth weight have differential influences on…
Subjects/Keywords: Genetics; Epidemiology; Growth; Development; Puberty
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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APA (6th Edition):
Hollis, B. (2019). Early Life Determinants of Metabolic and Reproductive Health. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/315196
Chicago Manual of Style (16th Edition):
Hollis, Benjamin. “Early Life Determinants of Metabolic and Reproductive Health.” 2019. Doctoral Dissertation, University of Cambridge. Accessed April 10, 2021.
https://www.repository.cam.ac.uk/handle/1810/315196.
MLA Handbook (7th Edition):
Hollis, Benjamin. “Early Life Determinants of Metabolic and Reproductive Health.” 2019. Web. 10 Apr 2021.
Vancouver:
Hollis B. Early Life Determinants of Metabolic and Reproductive Health. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Apr 10].
Available from: https://www.repository.cam.ac.uk/handle/1810/315196.
Council of Science Editors:
Hollis B. Early Life Determinants of Metabolic and Reproductive Health. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/315196

University of Gothenburg / Göteborgs Universitet
17.
Bygdell, Maria.
Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality.
Degree: 2019, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/58239
► Puberty in boys has long been an under-investigated area of research mainly due to the lack of an easily available pubertal marker, corresponding to menarche…
(more)
▼ Puberty in boys has long been an under-investigated area of research mainly due to the
lack of an easily available pubertal marker, corresponding to menarche for girls. Using
a unique, large, population-based cohort, this thesis targets some of the knowledge
gaps regarding puberty and BMI change during puberty in boys. We collected
information on height and weight throughout childhood until young adulthood for all
included subjects from archived school health records and from the military
conscription register, into the BMI Epidemiology study (BEST) cohort. Using these
measurements, we estimated prepubertal childhood BMI, post pubertal young adult
BMI, BMI change during puberty, and age at Peak Height Velocity (PHV) an
objective assessment of pubertal timing. Through linkage with the Cause of Death
register we obtained cause of death for all subjects. Childhood BMI and the
prevalence of overweight and obesity among 8-year-old boys have overall increased
substantially since birth year 1946 until birth year 2006. However, after a significant
increase in BMI starting in the 1970s and with a peak at birth year 1991, we observed
a moderate but significant decrease (Paper I). Furthermore, we have demonstrated
that childhood BMI was inversely associated with pubertal timing in normal weight
but not in overweight boys (Paper II). Age at PHV displayed a clear secular trend
towards earlier puberty among boys. Since the 1940s until birth year 1996, the
pubertal growth spurt was 1.5 months earlier per decade, and this trend could only
slightly be explained by the coinciding increase in childhood BMI (Paper III). We
demonstrated that BMI change during puberty, but not childhood BMI, was
independently associated with the risk of adult cardiovascular mortality. This
association between BMI change during puberty and cardiovascular mortality was
non-linear, with 22% increased risk of cardiovascular mortality per additional increase
in BMI units for individuals in the highest quartile. (Paper IV). This unique material
has enabled us to identify long-term trends of childhood BMI and pubertal timing, and
to identify a large BMI increase during puberty as a novel independent risk marker for
increased risk of adult cardiovascular mortality. The results from this thesis have the
potential to transmit directly into benefits for the society through adjustments of the
school health care program for improved identification of individuals at risk.
Subjects/Keywords: Childhood BMI; Puberty; BMI change during puberty; Cardiovascular mortality
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bygdell, M. (2019). Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/58239
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bygdell, Maria. “Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality.” 2019. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed April 10, 2021.
http://hdl.handle.net/2077/58239.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bygdell, Maria. “Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality.” 2019. Web. 10 Apr 2021.
Vancouver:
Bygdell M. Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/2077/58239.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bygdell M. Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. Available from: http://hdl.handle.net/2077/58239
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University
18.
Allen, Carolyn C.
Influence of Nutrition during the Juvenile Period on Gene Expression Within the Hypothalamic Arcuate Nucleus and on Age at Puberty in Heifers.
Degree: MS, Physiology of Reproduction, 2011, Texas A&M University
URL: http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8522
► Developmental changes within the hypothalamus are necessary for maturation of the reproductive neuroendocrine axis. Recent reports have implicated several neuronal networks in this process, but…
(more)
▼ Developmental changes within the hypothalamus are necessary for maturation of
the reproductive neuroendocrine axis. Recent reports have implicated several neuronal
networks in this process, but genes involved in their regulation have not been elucidated.
Using a well-established model for nutritional induction of precocious
puberty,
objectives were to 1) use microarray technology to examine changes in gene expression
within the arcuate nucleus (ARC) of the hypothalamus in pre-pubertal heifers fed high or
low-concentrate diets, and 2) determine if high-concentrate diets are required for
nutritional induction of precocious
puberty. In Experiment 1, early-weaned, cross-bred
heifers were fed either a high-forage/low-gain (HF/LG; 0.45 kg/d) or a highconcentrate/
high-gain (HC/HG; 0.91 kg/d) diet for 91 d. Analysis of microarray data
indicated that 346 genes were differentially expressed (P < 0.05) between HC/HG and
HF/LG heifers. Expression of three key metabolic genes [neuropeptide Y (NPY), agoutirelated
protein (AGRP), and growth hormone receptor (GHR)] observed to be
differentially expressed in the microarray analysis was investigated further by quantitative PCR. Real-time RT-PCR indicated that expression of NPY, AGRP and
GHR was lower (P < 0.05) in HC/HG compared to HF/LG heifers. In contrast,
concentrations of insulin (P < 0.05), IGF-1 (P < 0.002) and leptin (P = 0.1) were greater
in HC/HG compared to HF/LG. For Experiment 2, 48 heifers were used in 2 replicates
(24 heifers/replicate) in a 2 x 2 factorial design to examine the roles of diet type (HF vs
HC) and rate of gain (LG, 0.45 kg/d vs HG, 0.91 kg/d) on age at
puberty. Heifers were
fed HC/HG, HC/LG, HF/HG or HF/LG (n = 12/group) for 14 wk, and then switched to a
common growth diet (0.68 kg/d) until
puberty. Heifers in both HG groups reached
puberty at a younger age (54.5 ± 1.8 wk) than heifers in both LG groups (60.2 ± 1.9 wk;
P < 0.04). A marked increase (P < 0.01) in serum concentrations of leptin occurred in
HC/HG heifers between 24 and 30 wk of age. This increase in circulating leptin was not
observed in other groups. Overall, results indicate that nutritional regulation of
reproductive neuroendocrine development involves the control of NPY, AGRP and GHR
expression. The abrupt increase noted for circulating leptin in heifers fed HC/HG diets,
if timed and sustained appropriately, could represent an important temporal cue for
activation of the neuroendocrine system and the onset of
puberty.
Advisors/Committee Members: Williams, Gary L. (advisor), Amstalden, Marcel (advisor), Burghardt, Robert C. (committee member), Tedeschi, Luis O. (committee member).
Subjects/Keywords: Puberty; Arcuate Nucleus; Heifers; Neuropeptide Y; Leptin
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Allen, C. C. (2011). Influence of Nutrition during the Juvenile Period on Gene Expression Within the Hypothalamic Arcuate Nucleus and on Age at Puberty in Heifers. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8522
Chicago Manual of Style (16th Edition):
Allen, Carolyn C. “Influence of Nutrition during the Juvenile Period on Gene Expression Within the Hypothalamic Arcuate Nucleus and on Age at Puberty in Heifers.” 2011. Masters Thesis, Texas A&M University. Accessed April 10, 2021.
http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8522.
MLA Handbook (7th Edition):
Allen, Carolyn C. “Influence of Nutrition during the Juvenile Period on Gene Expression Within the Hypothalamic Arcuate Nucleus and on Age at Puberty in Heifers.” 2011. Web. 10 Apr 2021.
Vancouver:
Allen CC. Influence of Nutrition during the Juvenile Period on Gene Expression Within the Hypothalamic Arcuate Nucleus and on Age at Puberty in Heifers. [Internet] [Masters thesis]. Texas A&M University; 2011. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8522.
Council of Science Editors:
Allen CC. Influence of Nutrition during the Juvenile Period on Gene Expression Within the Hypothalamic Arcuate Nucleus and on Age at Puberty in Heifers. [Masters Thesis]. Texas A&M University; 2011. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8522

Texas A&M University
19.
Stribling, Emily Jean.
Production and Economic Effects of Developing Heifers on Three Different Levels of Stair-Step Nutrition Programs.
Degree: MS, Animal Science, 2018, Texas A&M University
URL: http://hdl.handle.net/1969.1/173319
► Links between nutrition and reproductive success in heifers are well established; however, achieving a high plane of nutrition is costly, and reproductive success remains uncertain,…
(more)
▼ Links between nutrition and reproductive success in heifers are well established; however, achieving a high plane of nutrition is costly, and reproductive success remains uncertain, making heifer development both expensive and risky. Development could be optimized by creating nutritionally efficient strategies that manage plane of nutrition without negatively impacting reproductive success. At an average age of 340 d (209 kg) 85 heifers were randomly assigned to 1 of 3 treatments: high (H, n = 29), programmed to gain 0.92 kg/d, medium (M, n = 28), 0.45 kg/d and low (L, n = 28), 0 kg/d from d 0 to d 49 (P1). All heifers were then programmed to gain 1.36 kg/d from d 50 to d 90 (P2). Heifers were individually fed a common diet (42% cracked corn, 26% DDG, 26% alfalfa hay, and 6% molasses; 14.0% CP, 1.1 Mcal NEg/kg) at different levels to achieve programmed rates of gain. Weekly BW and blood samples were collected. Digestion was measured beginning on d 41 (P1) and on d 83 (P2). All heifers were synchronized beginning on d 90 using the Bee-Synch protocol for fixed-time AI on d 98, followed by 56 d exposure to bulls. Pregnancy rates were determined on d 154. Gain differed between treatments in P1 (P < 0.01); M- and L-fed heifers exceeded programmed gain by 0.16 and 0.37 kg/d respectively (H = 0.83, M = 0.61, L = 0.37 kg/d), and tended to differ (P = 0.07) in P2 (H = 1.31, M = 1.41, L = 1.37 kg/d). Digestion in P1 differed (P = 0.01) between heifers fed H (86.2% DM) and L (88.7% DM); no differences (P = 0.23) were observed in P2. Total ADG and input costs were different among treatments (P < 0.01). Cost of development for the M and L treatments were 10 and 23 less per heifer, respectively, than H (95.35). Body weight and number pubertal on d 90 were not different (P > 0.10). Pregnancy rates on d 260 were not different (P = 0.99) being 97, 100, and 96% for H, M, and L, respectively. Developing heifers on a lower plane of nutrition decreased cost per pregnancy without apparent negative effects on reproductive success. The L strategy was the optimal development program based on cost per pregnancy; however, additional research is needed to confirm the effects on reproductive outcomes.
With various strategies being viable options in terms of successfully achieving pregnancy, it is often difficult to determine which is the best decision, economically, for a specific operation. A heuristic approach can easily be applied, subconsciously, to making managerial decisions of an operation, potentially leading to increased error in decision making. Therefore, a decision tool was developed comparing five different development programs. Programs were compared using net cost per pregnancy (CPP) to determine the optimal strategy, based on rational decisions, that would likely prove more consistent over time. A sensitivity analysis was conducted to evaluate the extent to which each variable accounted for impacted the CPP. Cost at weaning was observed as the most influential factor when selecting an optimal program, followed by other losses…
Advisors/Committee Members: Wickersham, Tryon A (advisor), Sawyer, Jason E (advisor), Cardoso, Rodolfo C (committee member), Anderson, David P (committee member).
Subjects/Keywords: Heifer; Development; Bos indicus; Puberty; Pregnancy
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stribling, E. J. (2018). Production and Economic Effects of Developing Heifers on Three Different Levels of Stair-Step Nutrition Programs. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173319
Chicago Manual of Style (16th Edition):
Stribling, Emily Jean. “Production and Economic Effects of Developing Heifers on Three Different Levels of Stair-Step Nutrition Programs.” 2018. Masters Thesis, Texas A&M University. Accessed April 10, 2021.
http://hdl.handle.net/1969.1/173319.
MLA Handbook (7th Edition):
Stribling, Emily Jean. “Production and Economic Effects of Developing Heifers on Three Different Levels of Stair-Step Nutrition Programs.” 2018. Web. 10 Apr 2021.
Vancouver:
Stribling EJ. Production and Economic Effects of Developing Heifers on Three Different Levels of Stair-Step Nutrition Programs. [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1969.1/173319.
Council of Science Editors:
Stribling EJ. Production and Economic Effects of Developing Heifers on Three Different Levels of Stair-Step Nutrition Programs. [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/173319

Texas A&M University
20.
Alves, Bruna R. C.
Nutritional Programming of Neuroendocrine Pathways Controlling the Onset of Puberty in Heifers.
Degree: PhD, Physiology of Reproduction, 2014, Texas A&M University
URL: http://hdl.handle.net/1969.1/152712
► Accelerated body weight gain during the juvenile period leads to early maturation of the reproductive neuroendocrine system and puberty by advancing the onset of high-frequency…
(more)
▼ Accelerated body weight gain during the juvenile period leads to early
maturation of the reproductive neuroendocrine system and
puberty by advancing the
onset of high-frequency release of gonadotropin-releasing hormone (GnRH). In a series
of studies conducted as part of this dissertation, it was hypothesized that nutritional
regimens that accelerate pubertal development alter the function of kisspeptin and
neuropeptide Y (NPY) neurons, known modulators of the release of GnRH. In addition,
alterations in the pattern of methylation of target genome sequences were investigated in
DNA collected from the arcuate nucleus, a hypothalamic region well-characterized for
its role in mediating the metabolic control of reproductive function. Early-weaned
crossbred heifers were fed diets to promote an average daily gain of 0.5 Kg (Low Gain;
n=12) or 1.0 Kg (High Gain; n=12) from approximately 4 to 8 mo of age. This
nutritional regimen has been demonstrated to facilitate early onset of
puberty in heifers.
At eight mo of age, heifers were slaughtered and a block of tissue containing the
preoptic area and hypothalamus was collected and processed for examining the
expression of NPY and KISS1, investigating the innervation of GnRH and kisspeptin
neurons by NPY fibers, and characterizing the methylation profile of target genomic
DNA sequences isolated from the arcuate nucleus. Mean body weight and circulating
concentrations of leptin were greater in High-gain than in Low-gain heifers. Elevated
rate of body weight gain was associated with reduced expression of NPY in the arcuate
nucleus, reduced proportion of GnRH neurons in apposition to NPY-containing
varicosities, particularly in GnRH neurons located in the mediobasal hypothalamus, and a reduced number of KISS1-expressing cells in the mid portion of the arcuate nucleus. The rate of body weight gain during the juvenile period did not affect NPY innervation of kisspeptin neurons. Differential methylation of target genomic DNA sequences isolated from the arcuate nucleus was observed in association with rate of body weight gain in juvenile heifers, and genes affected included GHR, IGF2, IGF1R, LEPR, PEG3, LIN28B and HMGA2. Overall, results from these studies support the hypothesis that accelerated body weight gain during the juvenile period promotes alterations in cellular functions within the hypothalamus that facilitate early onset of
puberty in heifers.
Advisors/Committee Members: Amstalden, Marcel (advisor), Williams, Gary L (committee member), Tedeschi, Luis O (committee member), Dindot, Scott V (committee member).
Subjects/Keywords: Puberty; cattle; nutrition; NPY; kisspeptin; epigenetics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Alves, B. R. C. (2014). Nutritional Programming of Neuroendocrine Pathways Controlling the Onset of Puberty in Heifers. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/152712
Chicago Manual of Style (16th Edition):
Alves, Bruna R C. “Nutritional Programming of Neuroendocrine Pathways Controlling the Onset of Puberty in Heifers.” 2014. Doctoral Dissertation, Texas A&M University. Accessed April 10, 2021.
http://hdl.handle.net/1969.1/152712.
MLA Handbook (7th Edition):
Alves, Bruna R C. “Nutritional Programming of Neuroendocrine Pathways Controlling the Onset of Puberty in Heifers.” 2014. Web. 10 Apr 2021.
Vancouver:
Alves BRC. Nutritional Programming of Neuroendocrine Pathways Controlling the Onset of Puberty in Heifers. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1969.1/152712.
Council of Science Editors:
Alves BRC. Nutritional Programming of Neuroendocrine Pathways Controlling the Onset of Puberty in Heifers. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/152712

Penn State University
21.
Joos, Celina Maria.
The Role of Puberty in the Development of Coping.
Degree: 2017, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/14903cmj192
► As children transition into adolescence, they demonstrate more sophisticated coping strategies that allow them to more effectively respond to daily and life stressors. These improvements…
(more)
▼ As children transition into adolescence, they demonstrate more sophisticated coping
strategies that allow them to more effectively respond to daily and life stressors. These
improvements are considered to be aspects of the normative, age-graded development of coping,
though there has been little scientific exploration of underlying biological developments that may
drive these alterations in coping. This study aimed to (a) create a theoretically-grounded model
of coping sophistication; (b) test which developmental factors may predict sophistication of
coping using structural equation modeling (SEM); and (c) explore gender differences in the ways
in which children cope with stress. Students in 4th and 5th grade (N=152) and their parent
completed measures of coping practices, psychopathology, stress exposure, and pubertal
development. A model of coping sophistication was found to be partially invariant across
genders and predictive of psychological wellbeing among boys. Neither age nor pubertal
development was predictive of coping sophistication, yet for boys greater stress exposure was
associated with poorer coping sophistication. Possible implications of gender differences in
coping sophistication are discussed. These findings are important for theoretical models of the
development of coping and underscore the need for additional, longitudinal research.
Advisors/Committee Members: Martha Wadsworth, Thesis Advisor/Co-Advisor, Kristin Buss, Committee Member, Lorah Dorn, Committee Member.
Subjects/Keywords: puberty; adolescence; stress; development of coping
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Joos, C. M. (2017). The Role of Puberty in the Development of Coping. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14903cmj192
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Joos, Celina Maria. “The Role of Puberty in the Development of Coping.” 2017. Thesis, Penn State University. Accessed April 10, 2021.
https://submit-etda.libraries.psu.edu/catalog/14903cmj192.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Joos, Celina Maria. “The Role of Puberty in the Development of Coping.” 2017. Web. 10 Apr 2021.
Vancouver:
Joos CM. The Role of Puberty in the Development of Coping. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Apr 10].
Available from: https://submit-etda.libraries.psu.edu/catalog/14903cmj192.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Joos CM. The Role of Puberty in the Development of Coping. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14903cmj192
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Leiden University
22.
Oreč, Inga.
Interpersonal relationships in times of pubertal development.
Degree: 2016, Leiden University
URL: http://hdl.handle.net/1887/37312
Subjects/Keywords: Adolescence; fMRI; Puberty
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APA (6th Edition):
Oreč, I. (2016). Interpersonal relationships in times of pubertal development. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/37312
Chicago Manual of Style (16th Edition):
Oreč, Inga. “Interpersonal relationships in times of pubertal development.” 2016. Masters Thesis, Leiden University. Accessed April 10, 2021.
http://hdl.handle.net/1887/37312.
MLA Handbook (7th Edition):
Oreč, Inga. “Interpersonal relationships in times of pubertal development.” 2016. Web. 10 Apr 2021.
Vancouver:
Oreč I. Interpersonal relationships in times of pubertal development. [Internet] [Masters thesis]. Leiden University; 2016. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1887/37312.
Council of Science Editors:
Oreč I. Interpersonal relationships in times of pubertal development. [Masters Thesis]. Leiden University; 2016. Available from: http://hdl.handle.net/1887/37312

Leiden University
23.
Selten, Ellen.
Hormonen en gedrag bij jongens met hoogfunctionerend autisme.
Degree: 2013, Leiden University
URL: http://hdl.handle.net/1887/25813
► Abstract Background. This study examines the relationship between hormonal parameters of puberty development and fetal testosterone levels with the presence of autistic symptoms, especially the…
(more)
▼ Abstract
Background. This study examines the relationship between hormonal parameters of
puberty development and fetal testosterone levels with the presence of autistic symptoms, especially the deficits in cognitive empathy in boys with high functioning autism (HFA) between nine and nineteen years old. According to several theories, hormones are involved in the etiology and behavioral characteristics of ASD in later life, such as problems with cognitive empathy. Method. In 45 HFA boys and 41 non-clinical boys, the degree of autistic symptoms is defined by the ADI-R and the SRS, and cognitive empathy is determined by the SCVT. Saliva samples are taken to determine testosterone, DHEA and estradiol levels. The fetal testosterone level was determined using the 2D:4D ratio. Results. Levels of fetal testosterone were significantly higher in HFA boys compared to non- clinical controls. Also, there is a connection between the fetal testosterone levels and cognitive deficits in cognitive empathy on the scale ‘discriminating perspectives’ in HFA boys. Higher scores are associated with higher fetal testosterone levels. Further research should incorporate the influence of mediating genes and neural structures, and should investigate the influence of hormones over a longer period, to assess the influence of hormones during social development.
Advisors/Committee Members: Rijn, Sophie van (advisor).
Subjects/Keywords: HFA; puberty hormones; prenatal testosterone; cognitive empathy
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
Selten, E. (2013). Hormonen en gedrag bij jongens met hoogfunctionerend autisme. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/25813
Chicago Manual of Style (16th Edition):
Selten, Ellen. “Hormonen en gedrag bij jongens met hoogfunctionerend autisme.” 2013. Masters Thesis, Leiden University. Accessed April 10, 2021.
http://hdl.handle.net/1887/25813.
MLA Handbook (7th Edition):
Selten, Ellen. “Hormonen en gedrag bij jongens met hoogfunctionerend autisme.” 2013. Web. 10 Apr 2021.
Vancouver:
Selten E. Hormonen en gedrag bij jongens met hoogfunctionerend autisme. [Internet] [Masters thesis]. Leiden University; 2013. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1887/25813.
Council of Science Editors:
Selten E. Hormonen en gedrag bij jongens met hoogfunctionerend autisme. [Masters Thesis]. Leiden University; 2013. Available from: http://hdl.handle.net/1887/25813

University of Wollongong
24.
Wild, Catherine Y.
How do the changes in musculoskeletal properties and oestrogen levels during the adolescent growth spurt affect landing technique in girls?.
Degree: PhD, 2012, University of Wollongong
URL: 110601
Biomechanics
;
https://ro.uow.edu.au/theses/3830
► BACKGROUND In girls, puberty is accompanied by the adolescent growth spurt, a large influx of oestrogen, as well as an increased risk of sustaining…
(more)
▼ BACKGROUND In girls, puberty is accompanied by the adolescent growth spurt, a large influx of oestrogen, as well as an increased risk of sustaining a non-contact anterior cruciate ligament (ACL) rupture. The rapid growth and hormonal changes experienced by girls throughout puberty are thought to play a role in this increased injury risk, contributing to altered lower limb inertial properties, ultimately affecting lower limb flexibility and strength, with the potential to influence landing biomechanics. However, the longitudinal changes in musculoskeletal structure and function, as well as oestrogen levels, in addition to the longitudinal development of landing technique throughout the adolescent growth spurt in girls, remains unclear.
THESIS AIM The primary purpose of this thesis was to investigate the longitudinal changes in musculoskeletal structure and function, as well as the oestrogen levels, during the adolescent growth spurt in girls and the influence of these changes on lower limb landing biomechanics.
METHODS Forty-six healthy girls, aged 10-13 years, were recruited for this longitudinal study based on their pubertal development (Tanner Stage II-III) and their time from peak height velocity (maturity offset; -6 to -4 months or 0 months). Participants were tested up to four times during the 12 months of their adolescent growth spurt, according to their maturity offset (Test 1: maturity offset = -6 to -4 months, Test 2: maturity offset = 0 months, Test 3: maturity offset = +4 months, Test 4: maturity offset = +8 months). During the laboratory test sessions, each participant’s anthropometric characteristics, oestrogen levels, anterior knee joint laxity, lower limb flexibility, isokinetic strength and landing biomechanics were collected and recorded. The landing task performed was a horizontal leap movement, during which ground reaction forces (1,000 Hz), lower limb electromyography (1,000 Hz) and kinematic data (100 Hz) were collected. Monthly tracking was also conducted, so as to estimate maturity offset using anthropometric data, as well as to determine monthly fluctuations in lower limb flexibility and strength.
Results from this longitudinal study were analysed and presented in four chapters (Chapter 3-6), with each chapter systematically contributing to the overall thesis aim. The primary purpose of Chapter 3 was to determine the longitudinal changes in anthropometry, anterior knee joint laxity, lower limb flexibility and strength, as well as the oestrogen levels, in pubescent girls during their growth spurt. Based on the findings from Chapter 3, the effects of variations in hamstring muscle strength (Chapter 4) and anterior knee joint laxity (Chapter 5) on the lower limb landing biomechanics of these pubescent girls were investigated. Finally, based on the longitudinal musculoskeletal changes displayed by girls in Chapter 3, the final experimental chapter of this thesis investigated the longitudinal changes in lower limb landing technique displayed by pubescent girls through their…
Subjects/Keywords: puberty; anterior cruciate ligament; jumping; lower limb
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Wild, C. Y. (2012). How do the changes in musculoskeletal properties and oestrogen levels during the adolescent growth spurt affect landing technique in girls?. (Doctoral Dissertation). University of Wollongong. Retrieved from 110601 Biomechanics ; https://ro.uow.edu.au/theses/3830
Chicago Manual of Style (16th Edition):
Wild, Catherine Y. “How do the changes in musculoskeletal properties and oestrogen levels during the adolescent growth spurt affect landing technique in girls?.” 2012. Doctoral Dissertation, University of Wollongong. Accessed April 10, 2021.
110601 Biomechanics ; https://ro.uow.edu.au/theses/3830.
MLA Handbook (7th Edition):
Wild, Catherine Y. “How do the changes in musculoskeletal properties and oestrogen levels during the adolescent growth spurt affect landing technique in girls?.” 2012. Web. 10 Apr 2021.
Vancouver:
Wild CY. How do the changes in musculoskeletal properties and oestrogen levels during the adolescent growth spurt affect landing technique in girls?. [Internet] [Doctoral dissertation]. University of Wollongong; 2012. [cited 2021 Apr 10].
Available from: 110601 Biomechanics ; https://ro.uow.edu.au/theses/3830.
Council of Science Editors:
Wild CY. How do the changes in musculoskeletal properties and oestrogen levels during the adolescent growth spurt affect landing technique in girls?. [Doctoral Dissertation]. University of Wollongong; 2012. Available from: 110601 Biomechanics ; https://ro.uow.edu.au/theses/3830

George Mason University
25.
Putman, Sarah.
Gonadal and Adrenal Hormone Patterns in African Lions (Panthera leo) of Diverse Age and Reproductive Success
.
Degree: 2017, George Mason University
URL: http://hdl.handle.net/1920/10520
► This study sought to gain a more thorough understanding of male and female African lion (Panthera leo) reproductive biology through non-invasive means. Compared to other…
(more)
▼ This study sought to gain a more thorough understanding of male and female African lion (Panthera leo) reproductive biology through non-invasive means. Compared to other felids housed in captivity, lions historically bred well. However, a 6-year period of low fecundity in the U.S. population was observed after the cessation of a breeding moratorium, so the North American African lion Species Survival Plan (SSP) requested assistance in identifying the cause. Additionally, wild lion populations are declining rapidly; thus, maintaining captive insurance populations and developing assisted reproductive technologies may be required to maintain genetic diversity and preserve the species. However, there is a dearth of basic information on lion reproductive biology, including
puberty onset and the impact of stress on reproductive function, which led to this biomedical survey of animals of varying ages and reproductive success within the captive population. Twenty six males from 18 zoos ranging in age from < 1 mo – 16.0 yr, and 38 females from 19 zoos, ranging in age from < 1 mo – 13.8 yr, were included in this study. Gonadal and adrenal steroid hormone metabolites were monitored in feces collected from 20 males and 28 females, body weights measurements were obtained ~monthly from 11 males and 17 females, and urine samples were collected from six males for spermaturia evaluation. Specific objectives of this study were to: 1) utilize non-invasive hormone monitoring to identify age and seasonal changes in gonadal and adrenal activity; 2) assess hormonal fluctuations related to reproductive events, such as pregnancy and estrus, to characterize reproductive life history stages; 3) examine
puberty onset using variation in hormone concentrations, reproductive events and body weight measurements in females, and changes in hormone concentrations, body weight and urinary sperm in males; and 4) obtain hormonal substantiation of contraceptive effects in female lions.
There was an increase in fecal androgen metabolite concentrations (FAM) at 2.0 yr of age, indicating a shift from peripubertal to subadult androgen production. While subadults had similar FAM to adult males, they had not reached a full adult weight.
Puberty occurred at an earlier age in captive than wild male lions; urinalysis for the presence of spermatozoa showed positive results in 83% of samples collected from males as young as 1.2 yr. Growth rates, based on body weight measurements, also was faster in captive individuals than wild counterparts. For females, longitudinal hormonal assessments showed that there were few age-related and no seasonality-related changes in ovarian steroid production after 0.9 yr. Based on fecal estrogen metabolites (FEM), 95% percent of individuals not treated with contraception were cycling normally; estrous cycle length averaged 17.5 ± 0.4 d, estrus was 4.4 ± 0.2 d and silent estrus was observed in 82% of females where behavioral observations were available. Pregnant luteal phases averaged 109.5 ± 1.0 d, while non-pregnant luteal phases…
Advisors/Committee Members: Birchard, Geoffrey (advisor).
Subjects/Keywords: African lion;
endocrinology;
felid;
puberty;
contraception;
reproduction
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Putman, S. (2017). Gonadal and Adrenal Hormone Patterns in African Lions (Panthera leo) of Diverse Age and Reproductive Success
. (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/10520
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Putman, Sarah. “Gonadal and Adrenal Hormone Patterns in African Lions (Panthera leo) of Diverse Age and Reproductive Success
.” 2017. Thesis, George Mason University. Accessed April 10, 2021.
http://hdl.handle.net/1920/10520.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Putman, Sarah. “Gonadal and Adrenal Hormone Patterns in African Lions (Panthera leo) of Diverse Age and Reproductive Success
.” 2017. Web. 10 Apr 2021.
Vancouver:
Putman S. Gonadal and Adrenal Hormone Patterns in African Lions (Panthera leo) of Diverse Age and Reproductive Success
. [Internet] [Thesis]. George Mason University; 2017. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1920/10520.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Putman S. Gonadal and Adrenal Hormone Patterns in African Lions (Panthera leo) of Diverse Age and Reproductive Success
. [Thesis]. George Mason University; 2017. Available from: http://hdl.handle.net/1920/10520
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto
26.
Schwartz, Alexander.
The Relationship of Testosterone, Appetite, Food Intake and Exercise in Male Adolescents.
Degree: PhD, 2019, University of Toronto
URL: http://hdl.handle.net/1807/97637
► The hypothesis that testosterone has an interactive relationship with food intake and high intensity exercise in adolescent males was explored in three experiments. Combined (Experiment…
(more)
▼ The hypothesis that testosterone has an interactive relationship with food intake and high intensity exercise in adolescent males was explored in three experiments. Combined (Experiment 1) and separate (Experiment 2) effects of acute glucose and protein ingestion on testosterone were observed. In Experiment 1, testosterone decreased by 18.6 ± 3.1% (p
Advisors/Committee Members: Anderson, Gerald H, Hamilton, Jill K, Nutritional Sciences.
Subjects/Keywords: appetite; exercise; glucose; protein; puberty; testosterone; 0570
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schwartz, A. (2019). The Relationship of Testosterone, Appetite, Food Intake and Exercise in Male Adolescents. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/97637
Chicago Manual of Style (16th Edition):
Schwartz, Alexander. “The Relationship of Testosterone, Appetite, Food Intake and Exercise in Male Adolescents.” 2019. Doctoral Dissertation, University of Toronto. Accessed April 10, 2021.
http://hdl.handle.net/1807/97637.
MLA Handbook (7th Edition):
Schwartz, Alexander. “The Relationship of Testosterone, Appetite, Food Intake and Exercise in Male Adolescents.” 2019. Web. 10 Apr 2021.
Vancouver:
Schwartz A. The Relationship of Testosterone, Appetite, Food Intake and Exercise in Male Adolescents. [Internet] [Doctoral dissertation]. University of Toronto; 2019. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1807/97637.
Council of Science Editors:
Schwartz A. The Relationship of Testosterone, Appetite, Food Intake and Exercise in Male Adolescents. [Doctoral Dissertation]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/97637

University of Minnesota
27.
Mueller, Noel Theodore.
Early puberty: adulthood metabolic consequences and childhood nutritional determinants.
Degree: PhD, Epidemiology, 2013, University of Minnesota
URL: http://purl.umn.edu/158968
► Background: Accumulating evidence suggests puberty is occurring earlier today than ever before. Pubertal timing may be a harbinger for abnormal metabolic health. Thus, identifying its…
(more)
▼ Background: Accumulating evidence suggests puberty is occurring earlier today than ever before. Pubertal timing may be a harbinger for abnormal metabolic health. Thus, identifying its upstream determinants and downstream metabolic health consequences may provide an avenue to primordial prevention. The objective of this dissertation was to investigate pubertal timing in relation to type 2 diabetes (T2D), adipose depots, non-alcoholic fatty liver disease (NAFLD), and early-life nutrition.
Methods: This dissertation includes three separate but related research manuscripts. The first aimed to investigate pubertal timing and T2D in a Brazilian adult population (35-74y) who were born and came of age before the rise of overweight and obesity in Brazil. The second examined pubertal timing in relation NAFLD and fat depots in a biracial cohort of young adults (18-30 years at entry, 42-56 years at measurement of NAFLD) from the Coronary Artery Risk Development In Young Adults (CARDIA) study. Finally, the third paper determined the role of diet quality and risk of early pubertal timing in a biracial sample of girls (9-10 years) from the National Heart, Lung, and Blood Institute Growth and Health Study (NGHS). Multivariable linear regression was used for continuous outcomes (glucose homeostasis measures, adipose depots, liver attenuation, and age at menarche) and Poisson regression to generate prevalence ratios (PR) and relative risks (RR) for dichotomous outcomes (T2D, NAFLD, and early menarche). In the last project, a diet quality score, derived by summing standard deviation scores for the densities of nutrients/chemicals indicative of prudent or Western dietary patterns, was analyzed in relation to incident early menarche.
Results: In the first paper: early menarche [<11 years vs. 13-14 years (reference)] was associated with 22% (95% confidence interval: 3-42%) higher prevalence of T2D in Brazilian adults, adjusted for confounders and BMI at age 20 years. In the same model, a 1-standard deviation higher relative leg length (RLL), a marker of early life growth and maturation, was associated with a 10% (5-15%) and 11% (7-15%) lower prevalence of T2D in women and men, respectively. The association between RLL and T2D was stronger among females with earlier menarche (p for interaction on multiplicative scale = 0.02), and among adults who were overweight or obese at age 20 years (p for interaction on multiplicative scale = 0.02) or 35-74 years (p for interaction on multiplicative scale = 0.03). In the second paper: in CARDIA, a 1-year increment in age at menarche was associated with 10% (2-18%) lower prevalence of NAFLD, and inversely associated with visceral, subcutaneous, and intra-abdominal muscle fat, after adjusting for confounders and BMI measured at 18-30 years. RLL was also associated with these measures, but was attenuated after control for BMI. Lastly, in the third paper: a better diet quality was associated with lower risk of early menarche (<11 years) after adjustment for confounders and % body fat from skinfolds…
Subjects/Keywords: Brazil; Diabetes; Liver disease; Obesity; Puberty
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mueller, N. T. (2013). Early puberty: adulthood metabolic consequences and childhood nutritional determinants. (Doctoral Dissertation). University of Minnesota. Retrieved from http://purl.umn.edu/158968
Chicago Manual of Style (16th Edition):
Mueller, Noel Theodore. “Early puberty: adulthood metabolic consequences and childhood nutritional determinants.” 2013. Doctoral Dissertation, University of Minnesota. Accessed April 10, 2021.
http://purl.umn.edu/158968.
MLA Handbook (7th Edition):
Mueller, Noel Theodore. “Early puberty: adulthood metabolic consequences and childhood nutritional determinants.” 2013. Web. 10 Apr 2021.
Vancouver:
Mueller NT. Early puberty: adulthood metabolic consequences and childhood nutritional determinants. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Apr 10].
Available from: http://purl.umn.edu/158968.
Council of Science Editors:
Mueller NT. Early puberty: adulthood metabolic consequences and childhood nutritional determinants. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://purl.umn.edu/158968

University of Guelph
28.
Howes, Colin.
Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice.
Degree: MS, Department of Psychology, 2016, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10138
► We investigated interactions between organizational and activational effects of gonadal hormones on social behaviour and cognition. Dams were treated with testosterone propionate or sesame oil…
(more)
▼ We investigated interactions between organizational and activational effects of gonadal hormones on social behaviour and cognition. Dams were treated with testosterone propionate or sesame oil control. Litters underwent a battery of behavioural assays in adolescence and in adulthood, following sham surgery, gonadectomy, or gonadectomy with estradiol/testosterone replacement. Castration improved social learning in male mice treated prenatally with oil, but blocked learning in mice treated prenatally with testosterone. Social learning was blocked in ovariectomized female mice treated prenatally with testosterone, but was recovered via estradiol replacement. Male mice were less sociable than females, and prenatal testosterone exaggerated this difference. Prenatal testosterone shifted male mice from dominance aggression towards territorial aggression when interacting with a cage-mate, and reduced submissiveness in interactions with an intruder among females. Prenatal testosterone increased anxiety-like behaviour only in male mice. Our results have implications for understanding the role of hormones in mediating social and social cognitive behaviour.
Advisors/Committee Members: Choleris, Elena (advisor), MacLusky, Neil (advisor).
Subjects/Keywords: Testosterone; Prenatal Development; Neuroendocrinology; Hormone Replacement; Puberty
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APA ·
Chicago ·
MLA ·
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Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Howes, C. (2016). Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10138
Chicago Manual of Style (16th Edition):
Howes, Colin. “Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice.” 2016. Masters Thesis, University of Guelph. Accessed April 10, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10138.
MLA Handbook (7th Edition):
Howes, Colin. “Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice.” 2016. Web. 10 Apr 2021.
Vancouver:
Howes C. Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice. [Internet] [Masters thesis]. University of Guelph; 2016. [cited 2021 Apr 10].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10138.
Council of Science Editors:
Howes C. Effects of Prenatal Testosterone Exposure and Adult Hormone Manipulation on Social Learning, Social Interactions, and Anxiety-Like Behaviour in Male and Female CD1 Mice. [Masters Thesis]. University of Guelph; 2016. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10138

University of Georgia
29.
Namulanda, Gonza.
In utero exposure to organochlorine and atrazine pesticides and early menarche in the Avon Longitudinal Study on Parents and Children cohort.
Degree: 2017, University of Georgia
URL: http://hdl.handle.net/10724/36831
► Introduction: Pesticides are toxic substances that can also cause unintended adverse effects, e.g., endocrine disruption, in exposed non-target populations such as humans. Some endocrine disrupting…
(more)
▼ Introduction: Pesticides are toxic substances that can also cause unintended adverse effects, e.g., endocrine disruption, in exposed non-target populations such as humans. Some endocrine disrupting compounds (EDCs) (e.g., the organochlorine
pesticide dichlorodiphenyltrichloroethane (DDT)) are identified as persistent organic pollutants while other suspected EDCs (e.g., atrazine) are less persistent in the body. A trend towards early puberty in girls has been observed in the United States
and Europe. This decline in the age of onset of puberty has been associated with several factors including exposures to EDCs. The endocrine disrupting effects due to population exposures to pesticides are still not well understood. Objectives: 1) To
characterize the in utero exposure of girls in the Avon Longitudinal Study on Parents and Children (ALSPAC) in Bristol, United Kingdom (UK) to organochlorine pesticides and examine the association with early menarche 2) To characterize the in utero
exposure of girls in ALSPAC to atrazine pesticide and examine the association with early menarche. Methods: Exposure to 9 organochlorine compounds and 7 atrazine analytes measured in maternal serum or urine collected during pregnancy was characterized
using non-parametric survival analysis methods. Logistic regression methods were used to examine the association between in utero exposure to these pesticides and early menarche. Results: Hexacholorbenzene (HCB), β-hexacholorocyclohexane (β-HCH),
2,2-Bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p’-DDT) and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene (p,p’-DDE) were detected in more than 50% of the study participants. Diaminochlorotriazine (DACT) was the only atrazine analyte detected in more than
50% of the study participants. Overall, there was no association between in utero exposure to organochlorines and early menarche. In utero exposure to higher levels of the atrazine metabolite DACT in the ALSPAC cohort was associated with an increased
odds of early menarche. Conclusions: More emphasis needs to be placed on measuring exposure in countries where organochlorine pesticides are still in use and evaluating their associations with adverse health effects. Our results suggest an association
between in utero exposure to the atrazine metabolite DACT and early menarche in the ALSPAC cohort. To accurately assess atrazine exposure in populations, several metabolites including DACT need to be measured.
Subjects/Keywords: Endocrine disrupting compounds; ALSPAC; menarche; early puberty
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APA ·
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MLA ·
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Export
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APA (6th Edition):
Namulanda, G. (2017). In utero exposure to organochlorine and atrazine pesticides and early menarche in the Avon Longitudinal Study on Parents and Children cohort. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/36831
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Namulanda, Gonza. “In utero exposure to organochlorine and atrazine pesticides and early menarche in the Avon Longitudinal Study on Parents and Children cohort.” 2017. Thesis, University of Georgia. Accessed April 10, 2021.
http://hdl.handle.net/10724/36831.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Namulanda, Gonza. “In utero exposure to organochlorine and atrazine pesticides and early menarche in the Avon Longitudinal Study on Parents and Children cohort.” 2017. Web. 10 Apr 2021.
Vancouver:
Namulanda G. In utero exposure to organochlorine and atrazine pesticides and early menarche in the Avon Longitudinal Study on Parents and Children cohort. [Internet] [Thesis]. University of Georgia; 2017. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10724/36831.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Namulanda G. In utero exposure to organochlorine and atrazine pesticides and early menarche in the Avon Longitudinal Study on Parents and Children cohort. [Thesis]. University of Georgia; 2017. Available from: http://hdl.handle.net/10724/36831
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana Tech
30.
Eickhoff, Elizabeth Kay.
Let’s talk about sex: A training program for parents of 4th and 5th grade children.
Degree: MA, 2013, Montana Tech
URL: https://scholarworks.umt.edu/etd/621
► The purpose of this study was to construct a training program for parents of 4th and 5th grade children on how to initiate and maintain…
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▼ The purpose of this study was to construct a training program for parents of 4th and 5th grade children on how to initiate and maintain conversations about safe-sex and sex-related topics by using Beebe, Mottet, and Roach’s (2013) Needs-Centered Training Model. The main topics arising from the needs assessment include experiencing puberty, healthy friendships, and peer pressure/media influence. The need for better communication surrounding sex can be seen from rates of teenage pregnancy in the United States remaining higher than those of other developed countries (Martinez, Copen, & Abma, 2011) as well as adolescents accounting for only a quarter of the sexually active population, but half of the population acquiring new STDs (Martinez, Copen, & Abma, 2011). Although this study does not address pregnancy and STD prevention, it encourages parents to initiate open conversation with their children about sex-related topics and to maintain this conversation so future topics (such as those concerning participating in sex) are more comfortable for both parent and child. Providing parents with information on important and age-appropriate topics for their children, as well as how to best initiate and maintain open and honest communication, can better equip parents to feel prepared for conversations with children that encourage them to act responsibly when it comes to sex-related situations in the future.
Subjects/Keywords: children; communication; parents; puberty; sex; training
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APA (6th Edition):
Eickhoff, E. K. (2013). Let’s talk about sex: A training program for parents of 4th and 5th grade children. (Masters Thesis). Montana Tech. Retrieved from https://scholarworks.umt.edu/etd/621
Chicago Manual of Style (16th Edition):
Eickhoff, Elizabeth Kay. “Let’s talk about sex: A training program for parents of 4th and 5th grade children.” 2013. Masters Thesis, Montana Tech. Accessed April 10, 2021.
https://scholarworks.umt.edu/etd/621.
MLA Handbook (7th Edition):
Eickhoff, Elizabeth Kay. “Let’s talk about sex: A training program for parents of 4th and 5th grade children.” 2013. Web. 10 Apr 2021.
Vancouver:
Eickhoff EK. Let’s talk about sex: A training program for parents of 4th and 5th grade children. [Internet] [Masters thesis]. Montana Tech; 2013. [cited 2021 Apr 10].
Available from: https://scholarworks.umt.edu/etd/621.
Council of Science Editors:
Eickhoff EK. Let’s talk about sex: A training program for parents of 4th and 5th grade children. [Masters Thesis]. Montana Tech; 2013. Available from: https://scholarworks.umt.edu/etd/621
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