subject:(Psychiatry)

University of Oxford

1. McDonald, Keltie. An investigation of the association between sleep disturbance and mood instability.

Degree: PhD, 2019, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:3c810d83-566d-4eae-8902-c859eb2ed942 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791723

► Mood instability (MI) and sleep disturbance (SD) are common in the general population, especially among persons with mental illness. Independently, MI and SD are associated… (more)

▼ Mood instability (MI) and sleep disturbance (SD) are common in the general population, especially among persons with mental illness. Independently, MI and SD are associated with a range of poor health outcomes; however, there exists little evidence about their relationship. Using a series of six studies, this thesis investigated the relationship between MI and SD as transdiagnostic features on a shared pathway to ill health. A systematic review of the prevalence of MI in the general population showed few and highly heterogeneous reports available within the literature. The results of the review highlight pervasive challenges underlying the study of MI, particularly the absence of consistent definitions and thoroughly validated measurement tools. To investigate the epidemiological association between MI and SD, studies two and three examined data from a nationally representative survey of English adult household residents. Study three revealed that both MI and SD are common and closely linked within the population and associated with increased occurrence of suicidal ideation and behaviour. Study four showed that MI and SD are strongly and significantly associated with a wide range of poor mental and physical health and social outcomes such as difficulties with activities of daily living, socioeconomic indicators, and diagnosed health conditions. In study four, prospective data on MI and SD from electronic health records from secondary mental health care showed that MI and SD are associated with significantly higher rates of mental health services use, hospitalisation, and prescribed medication. Finally, an attempt to disentangle the directionality between MI and SD found strong cross-sectional evidence, but weak evidence of temporal trends between mood and sleep changes. Taken together, the results of this thesis highlight existing and ongoing challenges to the study of highly temporal data on a large scale. However, the findings of this thesis provide essential knowledge for linking future epidemiological studies with high resolution examination of dynamic processes such as MI. Clinically, there is a critical need for increased recognition of MI and SD as modifiable risk factors of illness and related complications, rather than secondary symptoms. Earlier and effective intervention may help to reduce the burden associated with MI and SD, and mental illness.

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McDonald, K. (2019). An investigation of the association between sleep disturbance and mood instability. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:3c810d83-566d-4eae-8902-c859eb2ed942 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791723

Chicago Manual of Style (16^th Edition):

McDonald, Keltie. “An investigation of the association between sleep disturbance and mood instability.” 2019. Doctoral Dissertation, University of Oxford. Accessed March 04, 2021. http://ora.ox.ac.uk/objects/uuid:3c810d83-566d-4eae-8902-c859eb2ed942 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791723.

MLA Handbook (7^th Edition):

McDonald, Keltie. “An investigation of the association between sleep disturbance and mood instability.” 2019. Web. 04 Mar 2021.

Vancouver:

McDonald K. An investigation of the association between sleep disturbance and mood instability. [Internet] [Doctoral dissertation]. University of Oxford; 2019. [cited 2021 Mar 04]. Available from: http://ora.ox.ac.uk/objects/uuid:3c810d83-566d-4eae-8902-c859eb2ed942 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791723.

Council of Science Editors:

McDonald K. An investigation of the association between sleep disturbance and mood instability. [Doctoral Dissertation]. University of Oxford; 2019. Available from: http://ora.ox.ac.uk/objects/uuid:3c810d83-566d-4eae-8902-c859eb2ed942 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791723

Stellenbosch University

2. Schoeman, Renata. A prospective study of cognitive deficits in first episode psychosis, and the response thereof to treatment with Flupenthixol Decanoate.

Degree: Psychiatry, 2011, Stellenbosch University

URL: http://hdl.handle.net/10019.1/6727

►

Thesis (PhD (Psychiatry)) – University of Stellenbosch, 2011.

ENGLISH ABSTRACT: Contemporary research has confirmed the presence of cognitive deficits as a core feature of schizophrenia that… (more)

▼

Thesis (PhD (Psychiatry)) – University of Stellenbosch, 2011.

ENGLISH ABSTRACT: Contemporary research has confirmed the presence of cognitive deficits as a core feature of schizophrenia that has a definite and adverse impact on functional outcome. Cognitive functioning can be improved by psychopharmacological intervention, with evidence supporting the superiority of second generation antipsychotics over their first generation predecessors. Despite evidence that cognitive impairment contributes to medication non-adherence and that depot antipsychotics are able to enhance treatment compliance whilst decreasing relapse rates, depot preparations remain less frequently prescribed than their oral counterparts, especially in patients with first episode psychosis (FEP). The aims of this study were primarily to investigate cognitive deficits in patients with FEP, and to then describe the response of these impairments to treatment with a very low dose flupenthixol decanoate. This was a prospective, non-randomized, single arm, open-label, longitudinal study of 58 participants with FEP treated according to a fixed protocol over a period of 12 months. There was a wash-out phase of up to seven days during which all psychotropic medications were discontinued. There was an initial treatment period of one week with oral flupenthixol 1mg/day, after which flupenthixol decanoate was initiated at 10mg intramuscular depot injection every fortnight. Dose increases, in cases of poor or inadequate response, were allowed at 6-weekly intervals and in increments of 10mg per injection, up to a maximum of 30mg per fortnight. The principal findings of the study were as follows: The majority of participants were markedly ill, with significant cognitive impairment at baseline. There was a discrepancy between subjectively reported, and objectively measured, cognitive impairment. The majority of the participants responded to, and achieved remission, on a very low dose of flupenthixol decanoate (22.48 ± 0.47mg/month). The majority of symptomatic and cognitive improvement occurred between baseline and three months, with response leveling out at six months. Social cognition did not improve significantly over time, whereas functional outcome and quality of life did improve with treatment. Flupenthixol decanoate was well tolerated and side-effects were of a mild and transient nature. This study reconfirms that the majority of individuals with FEP experience significant cognitive impairment at baseline. It also suggests that these impairments can be successfully treated with a very low dose of flupenthixol decanoate. The use of depot flupenthixol decanoate ensures sustained treatment delivery, thereby decreasing the risk for relapse. This holds the promise of improved long-term functional outcome for those suffering with psychotic illness.

AFRIKAANSE OPSOMMING: Onlangse navorsing het kognitiewe inkorting identifiseer as een van die kern simptoomkomplekse van skisofrenie, met toenemende bewyse vir die duidelike en ongunstige impak hiervan op…

Advisors/Committee Members: Oosthuizen, P. P., University of Stellenbosch. Faculty of Health Sciences. Dept. of Psychiatry..

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schoeman, R. (2011). A prospective study of cognitive deficits in first episode psychosis, and the response thereof to treatment with Flupenthixol Decanoate. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/6727

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schoeman, Renata. “A prospective study of cognitive deficits in first episode psychosis, and the response thereof to treatment with Flupenthixol Decanoate.” 2011. Thesis, Stellenbosch University. Accessed March 04, 2021. http://hdl.handle.net/10019.1/6727.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schoeman, Renata. “A prospective study of cognitive deficits in first episode psychosis, and the response thereof to treatment with Flupenthixol Decanoate.” 2011. Web. 04 Mar 2021.

Vancouver:

Schoeman R. A prospective study of cognitive deficits in first episode psychosis, and the response thereof to treatment with Flupenthixol Decanoate. [Internet] [Thesis]. Stellenbosch University; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10019.1/6727.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schoeman R. A prospective study of cognitive deficits in first episode psychosis, and the response thereof to treatment with Flupenthixol Decanoate. [Thesis]. Stellenbosch University; 2011. Available from: http://hdl.handle.net/10019.1/6727

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

3. Roos, Annerine. Psychobiological correlates of distress in pregnancy.

Degree: Psychiatry, 2011, Stellenbosch University

URL: http://hdl.handle.net/10019.1/6712

►

Thesis (PhD (Psychiatry)) – University of Stellenbosch, 2011.

ENGLISH ABSTRACT: Pregnancy is often accompanied by distressing psychological symptoms such as anxiety. These symptoms may result from… (more)

▼

Thesis (PhD (Psychiatry)) – University of Stellenbosch, 2011.

ENGLISH ABSTRACT: Pregnancy is often accompanied by distressing psychological symptoms such as anxiety. These symptoms may result from changes in cognitive-affective processing, which in turn reflect hormonal changes during this time. However, findings on associations between psychological distress, cognitive-affective changes and hormones have been inconsistent. Furthermore, few studies have investigated the neural circuitry underlying distress and cognitive-affective processing in pregnancy. The prefrontal cortex (PFC) plays a specific role in regulating emotion. Determining the relationship between these changes in cognitive-affective processing and in prefrontal circuitry is important, given the high prevalence of depressive and anxiety disorders in pregnancy. The overall objective of this study was to investigate distressing psychological symptoms and their association with cognitive-affective processes and neurobiological changes over the course of pregnancy. Pregnant women with low risk singleton pregnancies were recruited from Midwife Obstetric Units in the Western Cape. Non-pregnant healthy controls were also recruited from the same demographic area. Distress levels were assessed using the K-10, Spielberger State -Trait Inventory, and Perceived Stress Scale. Subjectively experienced cognitive ability was asked about. Objective cognitive ability was assessed using standardized neuropsychological tests. Selective attention to threat such as fear and anger was assessed using a Facial Stroop Task. Neural circuitry was assessed using Near-Infrared Spectroscopy while viewing dynamic emotional facial expressions of threat (Emotion Recognition Task). Glucocorticoid (cortisol) and gonadal hormonal levels (estrogen, progesterone, and testosterone) were also determined at each trimester of pregnancy. Associations between distressing psychological symptoms, cognitive-affective processes and neurobiology were assessed using standard statistical methods. The main findings to emerge from this research were that, 1. pregnant women had significantly higher trait anxiety at trimester 2, compared to trimester 1 of pregnancy; 2. compared to non-pregnant women, pregnant women paid significantly more attention to fearful faces across trimesters, suggesting altered cognitive-affective processing in pregnancy compared to non-pregnancy; 3. pregnant women demonstrated significantly increased PFC activation in response to fearful and angry faces (all trimesters) that was particularly evident at trimester 2; 4. the PFC activation was, across trimesters, significantly correlated with distress and selective attention to threat; and 5. the PFC activation was, across trimesters, also significantly associated with increased glucocorticoid and gonadal hormone levels. The main findings of this study are consistent with previous literature insofar as distress has previously been associated with altered cognitive-affective processing and prefrontal cortex activation, but…

Advisors/Committee Members: Stein, Dan Joseph, Lochner, Christine, Vythilingum, Bavanisha, University of Stellenbosch. Faculty of Health Sciences. Dept. of Psychiatry..

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roos, A. (2011). Psychobiological correlates of distress in pregnancy. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/6712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Roos, Annerine. “Psychobiological correlates of distress in pregnancy.” 2011. Thesis, Stellenbosch University. Accessed March 04, 2021. http://hdl.handle.net/10019.1/6712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Roos, Annerine. “Psychobiological correlates of distress in pregnancy.” 2011. Web. 04 Mar 2021.

Vancouver:

Roos A. Psychobiological correlates of distress in pregnancy. [Internet] [Thesis]. Stellenbosch University; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10019.1/6712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roos A. Psychobiological correlates of distress in pregnancy. [Thesis]. Stellenbosch University; 2011. Available from: http://hdl.handle.net/10019.1/6712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

4. Ipser, Jonathan. The relationship between impulsivity, affect and a history of psychological adversity: a cognitive-affective neuroscience approach.

Degree: Image, Psychiatry and Mental Health, 2011, University of Cape Town

URL: http://hdl.handle.net/11427/11554

There is increasing evidence that trauma exposure is associated with impulsive behaviour and difficulties regulating affect. The findings of recent studies implicate the disruption of neurobiological mechanisms, particularly those involving the neurotransmitter serotonin, in both impulsivity and affect regulation. Advisors/Committee Members: Stein, Dan J (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ipser, J. (2011). The relationship between impulsivity, affect and a history of psychological adversity: a cognitive-affective neuroscience approach. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/11554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ipser, Jonathan. “The relationship between impulsivity, affect and a history of psychological adversity: a cognitive-affective neuroscience approach.” 2011. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/11554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ipser, Jonathan. “The relationship between impulsivity, affect and a history of psychological adversity: a cognitive-affective neuroscience approach.” 2011. Web. 04 Mar 2021.

Vancouver:

Ipser J. The relationship between impulsivity, affect and a history of psychological adversity: a cognitive-affective neuroscience approach. [Internet] [Thesis]. University of Cape Town; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/11554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ipser J. The relationship between impulsivity, affect and a history of psychological adversity: a cognitive-affective neuroscience approach. [Thesis]. University of Cape Town; 2011. Available from: http://hdl.handle.net/11427/11554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

5. Koen, Nastassja. Psychological trauma and posttraumatic stress disorder in a South African birth cohort study.

Degree: Image, Psychiatry and Mental Health, 2015, University of Cape Town

URL: http://hdl.handle.net/11427/20264

► Psychological trauma - including exposure to intimate partner violence (IPV) - is highly prevalent in South Africa, and may result in posttraumatic stress disorder (PTSD)… (more)

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koen, N. (2015). Psychological trauma and posttraumatic stress disorder in a South African birth cohort study. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/20264

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koen, Nastassja. “Psychological trauma and posttraumatic stress disorder in a South African birth cohort study.” 2015. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/20264.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koen, Nastassja. “Psychological trauma and posttraumatic stress disorder in a South African birth cohort study.” 2015. Web. 04 Mar 2021.

Vancouver:

Koen N. Psychological trauma and posttraumatic stress disorder in a South African birth cohort study. [Internet] [Thesis]. University of Cape Town; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/20264.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koen N. Psychological trauma and posttraumatic stress disorder in a South African birth cohort study. [Thesis]. University of Cape Town; 2015. Available from: http://hdl.handle.net/11427/20264

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

6. Gevers, Aník. An exploration of the nature of contemporaty adolescents' intimate relationships.

Degree: Image, Psychiatry and Mental Health, 2013, University of Cape Town

URL: http://hdl.handle.net/11427/12348

► Intimate relationships in adolescence play an important role in psychosocial development and can impact on relationships during adulthood. There is a need for evidence-based interventions… (more)

▼ Intimate relationships in adolescence play an important role in psychosocial development and can impact on relationships during adulthood. There is a need for evidence-based interventions to prevent intimate partner violence (IPV), promote sexual and reproductive health, and equitable, enjoyable relationships during adolescence. A nuanced understanding of contemporary adolescents' intimate relationships is needed to inform intervention development. A series of studies was undertaken to explore (a) contemporary adolescents' ideas about and experiences of relationships; (b) young adolescents' sexual behaviour and dating; (c) adolescents' conceptions of a good relationship; and (d) published-evidence guidelines for developing school-based violence prevention interventions. For study (a), qualitative data were collected during focus group discussions and in-depth interviews with 14-18 year olds. Survey data from 13-16 year olds (for study b) and 15-18 year olds (for study c) were analysed using regression analyses. Adolescentsâ€™ intimate relationships are fluid and unstructured, highly gendered, and greatly influenced by peer relationships; however, experience with relationships and sex are varied. For girls, good relationships were associated with having a mutual main partnership with an older, educated boyfriend in which there was good, open communication particularly about sexual and reproductive health. For boys, a mutual main partnership and very little quarrelling were associated with good relationships. Young adolescents' reported engaging in a variety of sexual behaviours ranging from kissing to sexual intercourse with the former more common than the latter. These findings indicate a need for early interventions that are carefully adapted and acceptable to adolescents who have varying levels of experience with relationships, sex, and violence. Adolescents would benefit from developing gender equitable attitudes; critically reflecting on their ideas and practices related to good and poor relationships; building sexual decision-making skills to better prepare them to develop and maintain good, healthy relationships and end poor or abusive ones. Interventions should incorporate adolescents' perspectives and balance evidence-based best practice and resource availability. Advisors/Committee Members: Flisher, Alan J (advisor), Mathews, Catherine (advisor), Jewkes, Rachel (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gevers, A. (2013). An exploration of the nature of contemporaty adolescents' intimate relationships. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/12348

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gevers, Aník. “An exploration of the nature of contemporaty adolescents' intimate relationships.” 2013. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/12348.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gevers, Aník. “An exploration of the nature of contemporaty adolescents' intimate relationships.” 2013. Web. 04 Mar 2021.

Vancouver:

Gevers A. An exploration of the nature of contemporaty adolescents' intimate relationships. [Internet] [Thesis]. University of Cape Town; 2013. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/12348.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gevers A. An exploration of the nature of contemporaty adolescents' intimate relationships. [Thesis]. University of Cape Town; 2013. Available from: http://hdl.handle.net/11427/12348

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

7. Saban, Amina. The association betweeen psychopathology and substance use in young people.

Degree: Image, Psychiatry and Mental Health, 2011, University of Cape Town

URL: http://hdl.handle.net/11427/12248

► The co-occurrence of problematic substance use and non-substance use psychopathology is very common in psychiatry, and is generally referred to as comorbidity. The phenomenon has… (more)

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saban, A. (2011). The association betweeen psychopathology and substance use in young people. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/12248

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Saban, Amina. “The association betweeen psychopathology and substance use in young people.” 2011. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/12248.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Saban, Amina. “The association betweeen psychopathology and substance use in young people.” 2011. Web. 04 Mar 2021.

Vancouver:

Saban A. The association betweeen psychopathology and substance use in young people. [Internet] [Thesis]. University of Cape Town; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/12248.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Saban A. The association betweeen psychopathology and substance use in young people. [Thesis]. University of Cape Town; 2011. Available from: http://hdl.handle.net/11427/12248

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

8. Carney, Tara. Evidence-based screening, brief intervention and referral to treatment for substance-using adolescents with delinquent-type behaviours.

Degree: Image, Psychiatry and Mental Health, 2014, University of Cape Town

URL: http://hdl.handle.net/11427/13182

► Background: Both substance use and delinquent-type behaviours are prevalent among adolescents in Cape Town, South Africa. However, early interventions in developed countries for adolescents with… (more)

▼ Background: Both substance use and delinquent-type behaviours are prevalent among adolescents in Cape Town, South Africa. However, early interventions in developed countries for adolescents with similar problems are not available in many low and middle income countries, including South Africa. This is a concern as providing evidence-based interventions that address these dual behavioural problems may prevent their progression. There is thus a need for identifying and understanding the kinds of interventions that would be able to address both of these problems Aim: The aim of this thesis is to identify an evidence-based intervention for reducing adolescent substance use and delinquent-type behaviours and adapt it for use among adolescents in Cape Town, South Africa. Method: This study comprised six parts. Study I utilised a longitudinal data set to examine the association between substance use and delinquent-type behaviours, as well as the trajectory of these behaviours among school-going adolescents in Cape Town. As one needs to know how to identify adolescents who would benefit from such an intervention, Study II identified suitable screening tools for identifying these adolescents. While screening tools are generally brief instruments to identify problems with substance use, assessment instruments for those adolescents who screen positive would more comprehensively assist in the further evaluation of their problem behaviours, as well as measure other risk factors for substance use and delinquent-type behaviour. Study III therefore tested and adapted assessment tools for those adolescents who screen positive for substance use and delinquent-type behaviour. The next step was to identify a suitable evidence-based brief intervention that addressed substance use and delinquent-type behaviours in an integrated manner. Study IV consisted of a systematic review and meta-analysis to identify such an intervention. As only studies from developed countries were included in the review, the final two studies concentrated on adapting the intervention identified in Study IV with service providers and adolescents in focus groups 6. Study V consisted of a cultural adaptation which tested the ecological validity of the identified brief intervention in Cape Town communities. Study VI was a content adaptation that modified the brief intervention for adolescents in this context, and to include a focus on delinquent-type behaviours. Results: The final result is a screening, brief intervention and referral to treatment (SBIRT) package that is ready to be tested for efficacy on substance use and delinquent type behavioural outcomes. Each study contributes to the different components that make up this package. The results from the longitudinal study indicated that while substance use is not predictive of delinquent-type behaviours, these two behaviours co-occur at different stages of adolescence. In addition, adolescents that smoked and were delinquent were at significantly higher risk of engaging in later delinquent-type behaviour. This… Advisors/Committee Members: Myers, Bronwyn Jane (advisor), Louw, Johann (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carney, T. (2014). Evidence-based screening, brief intervention and referral to treatment for substance-using adolescents with delinquent-type behaviours. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/13182

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carney, Tara. “Evidence-based screening, brief intervention and referral to treatment for substance-using adolescents with delinquent-type behaviours.” 2014. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/13182.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carney, Tara. “Evidence-based screening, brief intervention and referral to treatment for substance-using adolescents with delinquent-type behaviours.” 2014. Web. 04 Mar 2021.

Vancouver:

Carney T. Evidence-based screening, brief intervention and referral to treatment for substance-using adolescents with delinquent-type behaviours. [Internet] [Thesis]. University of Cape Town; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/13182.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carney T. Evidence-based screening, brief intervention and referral to treatment for substance-using adolescents with delinquent-type behaviours. [Thesis]. University of Cape Town; 2014. Available from: http://hdl.handle.net/11427/13182

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

9. Van der Westhuizen, Claire. Mental disorders and violence-related injuries : prevention opportunities in emergency centres.

Degree: Image, Psychiatry and Mental Health, 2014, University of Cape Town

URL: http://hdl.handle.net/11427/13049

► Mental disorders and violence-related injuries make significant contributions to the global disease burden, mostly affecting young people. In emergency centres, mental disorders and violence-related injuries… (more)

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Van der Westhuizen, C. (2014). Mental disorders and violence-related injuries : prevention opportunities in emergency centres. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/13049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Van der Westhuizen, Claire. “Mental disorders and violence-related injuries : prevention opportunities in emergency centres.” 2014. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/13049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Van der Westhuizen, Claire. “Mental disorders and violence-related injuries : prevention opportunities in emergency centres.” 2014. Web. 04 Mar 2021.

Vancouver:

Van der Westhuizen C. Mental disorders and violence-related injuries : prevention opportunities in emergency centres. [Internet] [Thesis]. University of Cape Town; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/13049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Van der Westhuizen C. Mental disorders and violence-related injuries : prevention opportunities in emergency centres. [Thesis]. University of Cape Town; 2014. Available from: http://hdl.handle.net/11427/13049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

10. Pike, Alexandra. Eating disorders and compulsivity : neural, computational, and psychopharmacological approaches.

Degree: PhD, 2018, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:7e94fa3c-8a20-4211-89fc-33287e456842 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780503

► This DPhil thesis takes the transdiagnostic construct of compulsivity as a basis for investigation into eating disorders, which are severe psychiatric disorders with high mortality… (more)

▼ This DPhil thesis takes the transdiagnostic construct of compulsivity as a basis for investigation into eating disorders, which are severe psychiatric disorders with high mortality rates. This thesis includes three experimental studies (discussed in Chapters 3 to 5), which investigate different aspects of eating disorders and compulsivity. The first experimental study (Chapter 3) is a multimodal magnetic resonance imaging study, in which the neural basis of compulsivity was investigated in participants who had recovered from anorexia nervosa and control participants. We used a task with functional magnetic resonance imaging which incorporated key elements of compulsivity, performed a resting-state analysis with frontostriatal seeds, and analysed glutamate levels using magnetic resonance spectroscopy. We neither found evidence of the hypothesised frontostriatal differences, nor of a difference in glutamate levels in participants, but did find parietal differences in both the resting-state and task-based analyses. The next study, discussed in Chapter 4, aimed to investigate adaptive learning in eating disorders. We predicted that participants in two clinically-relevant groups (those who had recovered from anorexia nervosa, and those who had elevated eating disorder symptoms) would show diminished adaptation of their learning rates in a task which manipulated environmental volatility, and that this would correspond to a reduction in pupil dilation to volatile outcomes in these groups compared to control participants. However, we found elevated adaptation of learning rates in those who had recovered from anorexia nervosa, which may be attributed to heightened learning rates in this group in particular in the first block. The final experimental study is discussed in Chapter 5, and investigated whether a dietary supplement, N-acetylcysteine, would improve performance of those with elevated eating disorder symptoms on tasks which measure compulsive and impulsive responding. However, this did not seem to be the case, though N-acetylcysteine was well-tolerated.

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pike, A. (2018). Eating disorders and compulsivity : neural, computational, and psychopharmacological approaches. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:7e94fa3c-8a20-4211-89fc-33287e456842 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780503

Chicago Manual of Style (16^th Edition):

Pike, Alexandra. “Eating disorders and compulsivity : neural, computational, and psychopharmacological approaches.” 2018. Doctoral Dissertation, University of Oxford. Accessed March 04, 2021. http://ora.ox.ac.uk/objects/uuid:7e94fa3c-8a20-4211-89fc-33287e456842 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780503.

MLA Handbook (7^th Edition):

Pike, Alexandra. “Eating disorders and compulsivity : neural, computational, and psychopharmacological approaches.” 2018. Web. 04 Mar 2021.

Vancouver:

Pike A. Eating disorders and compulsivity : neural, computational, and psychopharmacological approaches. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Mar 04]. Available from: http://ora.ox.ac.uk/objects/uuid:7e94fa3c-8a20-4211-89fc-33287e456842 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780503.

Council of Science Editors:

Pike A. Eating disorders and compulsivity : neural, computational, and psychopharmacological approaches. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:7e94fa3c-8a20-4211-89fc-33287e456842 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780503

University of Cape Town

11. Berwers, Juan. The diagnostic yield of computerised tomography in human immunodeficiency virus (HIV) positive psychiatric patients at a tertiary hospital in the Western Cape.

Degree: Image, Psychiatry and Mental Health, 2017, University of Cape Town

URL: http://hdl.handle.net/11427/27453

► Background. HIV infection increases the risk for mental illness. Neuroimaging is an important part of the diagnostic workup in HIV+ psychiatric patients; CT is the… (more)

▼ Background. HIV infection increases the risk for mental illness. Neuroimaging is an important part of the diagnostic workup in HIV+ psychiatric patients; CT is the primary neuroimaging modality available in resource limited settings. Despite advances in neuroimaging no clear guidelines exist for the use of CT in psychiatric settings. Objective. To determine the diagnostic yield of CT brain (CTB) scans in HIV+ psychiatric patients and to describe these abnormalities as well as demographic and clinical variables associated with abnormal CT scans. Methods. A retrospective study was conducted at the Department of Psychiatry and Mental illness at Groote Schuur Hospital, Cape Town, South Africa. Clinical and radiological data for HIV+ psychiatric patients who received a CTB scan during admission were analysed for the period January 2013 - June 2015. Results. A total of 65 patients met the inclusion criteria. The mean age of the participants in this study was 36.2 years (range 18 - 64). The most common presenting psychiatric symptoms were psychosis (81.54%), cognitive deficits (72.41%) and mood symptoms (69.23%). CT scans results consisted of 29 (44.62%) normal scans and 36 (55.38%) abnormal scans. Atrophy was the most common (72%) radiological finding in abnormal CT scans. No associations were found between current proposed CT guidelines in psychiatric patients, although a history of previous traumatic brain injury (TBI) approached significance (p = 0.054). There was a significant correlation between abnormal CT scans and past or current substance use (X² = 5.9508 P = .015). Abnormal CT findings increased with the Centers for Disease Control and Prevention (CDC) HIV immunological stage progression. The management of 9 patients changed; 7 of these CT scans were abnormal. Conclusion. In this study of CTB scans in HIV+ psychiatric inpatients, previously suggested criteria proposed in guidelines for imaging were not associated with significantly higher rates of abnormal CT findings. Current or previous substance use correlated with significant higher rates of abnormal CT findings. Due to the high yield of abnormal CT scans in this study, it is suggested that HIV+ psychiatric inpatients with previous or current substance use, a history of TBI or HIV immunological stages B or C, are considered for imaging. It is recommended that further studies with larger sample sizes, consisting of inpatient and outpatient populations, with control groups be conducted to investigate current or previous substance use as an indication in guidelines for CTB scan in HIV+ psychiatric patients. Advisors/Committee Members: Joska, John A (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Berwers, J. (2017). The diagnostic yield of computerised tomography in human immunodeficiency virus (HIV) positive psychiatric patients at a tertiary hospital in the Western Cape. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/27453

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Berwers, Juan. “The diagnostic yield of computerised tomography in human immunodeficiency virus (HIV) positive psychiatric patients at a tertiary hospital in the Western Cape.” 2017. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/27453.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Berwers, Juan. “The diagnostic yield of computerised tomography in human immunodeficiency virus (HIV) positive psychiatric patients at a tertiary hospital in the Western Cape.” 2017. Web. 04 Mar 2021.

Vancouver:

Berwers J. The diagnostic yield of computerised tomography in human immunodeficiency virus (HIV) positive psychiatric patients at a tertiary hospital in the Western Cape. [Internet] [Thesis]. University of Cape Town; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/27453.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Berwers J. The diagnostic yield of computerised tomography in human immunodeficiency virus (HIV) positive psychiatric patients at a tertiary hospital in the Western Cape. [Thesis]. University of Cape Town; 2017. Available from: http://hdl.handle.net/11427/27453

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

12. Charles, Bhaskaran Nathamaniar. A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions.

Degree: MMed, Psychiatry and Mental Health, 2018, University of Cape Town

URL: http://hdl.handle.net/11427/29562

► Background: The impact on hospitalisations/ relapse rates of utilising long-acting antipsychotic injectable (LAIs) in a South African population suffering from chronic psychotic spectrum mental illness… (more)

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Charles, B. N. (2018). A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/29562

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Charles, Bhaskaran Nathamaniar. “A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions.” 2018. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/29562.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Charles, Bhaskaran Nathamaniar. “A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions.” 2018. Web. 04 Mar 2021.

Vancouver:

Charles BN. A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions. [Internet] [Thesis]. University of Cape Town; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/29562.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Charles BN. A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions. [Thesis]. University of Cape Town; 2018. Available from: http://hdl.handle.net/11427/29562

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

13. Louw, Kerry-Ann. Prevalence and patterns of medication use in children and adolescents with Autism Spectrum Disorders in the Western Cape.

Degree: Image, Psychiatry and Mental Health, 2012, University of Cape Town

URL: http://hdl.handle.net/11427/11626

► The Autism Spectrum Disorders(ASD) are a group of neurobiological conditions of growing prevalence for which there is no known cure. International prevalence studies have determined… (more)

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Louw, K. (2012). Prevalence and patterns of medication use in children and adolescents with Autism Spectrum Disorders in the Western Cape. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/11626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Louw, Kerry-Ann. “Prevalence and patterns of medication use in children and adolescents with Autism Spectrum Disorders in the Western Cape.” 2012. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/11626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Louw, Kerry-Ann. “Prevalence and patterns of medication use in children and adolescents with Autism Spectrum Disorders in the Western Cape.” 2012. Web. 04 Mar 2021.

Vancouver:

Louw K. Prevalence and patterns of medication use in children and adolescents with Autism Spectrum Disorders in the Western Cape. [Internet] [Thesis]. University of Cape Town; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/11626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Louw K. Prevalence and patterns of medication use in children and adolescents with Autism Spectrum Disorders in the Western Cape. [Thesis]. University of Cape Town; 2012. Available from: http://hdl.handle.net/11427/11626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

14. Koller, Anthony. The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis.

Degree: Image, Psychiatry and Mental Health, 2016, University of Cape Town

URL: http://hdl.handle.net/11427/23047

► Generalised anxiety disorder (GAD) is a common, chronic and debilitating mental disorder impairing quality of life and functioning. The 1st line treatments for GAD include… (more)

▼ Generalised anxiety disorder (GAD) is a common, chronic and debilitating mental disorder impairing quality of life and functioning. The 1st line treatments for GAD include the selective serotonergic reuptake inhibitors (SSRIs) and the selective serotonergic noradrenergic reuptake inhibitors (SNRIs). However, they have rates of non-response ranging from 25 to 40%. There is justification to search for new and more efficacious GAD medication. It has hypothesised anticonvulsants possess anxiolytic properties based on animal studies and epilepsy trials. There is inconsistent evidence that anticonvulsants are efficacious in GAD. It was considered useful and timely to investigate this further. The newer anticonvulsants (felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, tiagabine, topiramate and zonisamide) were investigated as they were considered to have a more benign side effect profile and fewer drug interactions than older anticonvulsants. This study is a systematic review and meta-analysis of the newer anticonvulsants in the treatment of GAD. The main objective was to use randomised controlled trial (RCT) data to estimate efficacy of the newer anticonvulsants in GAD. using A search strategy was designed and three separate searches conducted by the Cochrane Depression Anxiety and Neurosis Group of the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register (CCDANCTR) and clinicaltrials.gov (the last search in May 2013). An updated, independent, search was conducted in May 2016 with no additional citations retrieved. 287 citations were retrieved and screened in total. Two independent raters assessed citations using the abstracts and selected trials that satisfied the inclusion criteria. 12 RCTs were included with eight using pregabalin and four using tiagabine. A single rater collated data from RCTs assisted by Covidence Systematic Review Software. All statistical analyses were performed using Review Manager. A random effects meta-analysis was performed expressing summary statistics as effect estimates with 95% confidence intervals (CI). There were 4001 participants in total with 2516 in the anticonvulsant group and 1485 in the placebo. Primary outcomes were reduction in symptom severity using the Hamilton Anxiety Rating Scale (HAM-A) and treatment response using the Clinical Global Impressions Scale-Improvement item (CGI-I). Secondary outcome was medication acceptability. Reduction of symptom severity on the HAM-A for: the anticonvulsant group (pregabalin and tiagabine combined) was significantly favourable with a mean difference (MD) of -2.10 ([-2.83, -1.36] 95% CI); pregabalin was significantly favourable (MD -2.86 [-3.52, -2.21] 95% CI) tiagabine was statistically insignificant (MD - 0.58 [-1.41, 0.25] 95% CI). The risk ratio (RR) of treatment response using the CGI-I (RR >1 favours the anticonvulsant) for: the anticonvulsant group was significantly favourable (RR 1.23 [1.12, 1.35] 95% CI); pregabalin was significantly favourable (RR 1.35 [1.21, 1.50] 95% CI)… Advisors/Committee Members: Stein, Dan J (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koller, A. (2016). The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/23047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koller, Anthony. “The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis.” 2016. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/23047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koller, Anthony. “The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis.” 2016. Web. 04 Mar 2021.

Vancouver:

Koller A. The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis. [Internet] [Thesis]. University of Cape Town; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/23047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koller A. The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis. [Thesis]. University of Cape Town; 2016. Available from: http://hdl.handle.net/11427/23047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

15. Mungly, Shazia. The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital.

Degree: MMed, Psychiatry and Mental Health, 2019, University of Cape Town

URL: http://hdl.handle.net/11427/31076

► Background: Various studies have shown that people with serious mental illness have an increased risk for metabolic syndrome with prevalence ranging from 28.7% to 60%.… (more)

▼ Background: Various studies have shown that people with serious mental illness have an increased risk for metabolic syndrome with prevalence ranging from 28.7% to 60%. Given the amount of evidence suggesting a link between clozapine and metabolic syndrome, several guidelines have recommended regular clinical monitoring of metabolic syndrome in patients on clozapine. Aim: To determine the screening, prevalence and associated risk factors of metabolic disorders in forensic patients with schizophrenia spectrum disorders who are on clozapine (study group) compared to patients on haloperidol (control group). Methods: It is a retrospective, folder review of forensic male adult patients at Valkenberg Hospital, Observatory Cape Town. Results: There were 45 patients in the study group and 23 patients in the control group. Eight patients (17.8%) in the study group (Clozapine) met criteria for metabolic syndrome according to the NCEP-ATP III criteria and none of the patients in the control group (Haloperidol) did (χ 2 (1) = 4.441, p = .035 V = .257). Patients who had a diagnosis of schizoaffective disorder were also on mood stabilisers in addition to clozapine. Again, while none of the patients on Haloperidol met the criteria for Metabolic syndrome, 6 (24%) of the 25 patients on concurrent Clozapine and sodium valproate did, (χ 2 (1) = 6.051, p = .023 V = .359). In terms of metabolic disorders, a significantly higher proportion of patients in the study group has hypertension and hyperlipidaemia (p = .003 and p = .021 respectively). Less than 25% of all patients were fully screened for metabolic syndrome. There was a very low rate of screening of blood tests: fasting glucose, total cholesterol, trigylcerides, High Density Lipoprotein(HDL) or Low-Density Lipoprotein (LDL). Conclusion: The prevalence of metabolic syndrome was higher in the clozapine group than haloperidol group, which is unsurprising since clozapine is usually associated with a higher risk of metabolic syndrome. However, the prevalence on metabolic syndrome in this study sample was relatively low compared to other studies. This could be due to the low rate of screening of each criteria of metabolic syndrome. Screening for metabolic syndrome should be regularly performed by health professionals in patients with serious mental illness. Further studies are needed to investigate the risk of metabolic syndrome for patients who are on a combination of clozapine and mood stabilisers. Advisors/Committee Members: Kaliski, Sean (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mungly, S. (2019). The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mungly, Shazia. “The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital.” 2019. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/31076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mungly, Shazia. “The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital.” 2019. Web. 04 Mar 2021.

Vancouver:

Mungly S. The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital. [Internet] [Thesis]. University of Cape Town; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/31076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mungly S. The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital. [Thesis]. University of Cape Town; 2019. Available from: http://hdl.handle.net/11427/31076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

16. Torline, John Ross. Inpatient referrals to consultation-liaison psychiatry at a tertiary hospital in South Africa.

Degree: Image, Psychiatry and Mental Health, 2016, University of Cape Town

URL: http://hdl.handle.net/11427/23045

► Introduction. Consultation-liaison psychiatry is the subspeciality that provides for the psychiatric assessment and management of patients in a hospital setting, serving as an interface between… (more)

▼ Introduction. Consultation-liaison psychiatry is the subspeciality that provides for the psychiatric assessment and management of patients in a hospital setting, serving as an interface between psychiatry and other medical disciplines. This study aimed to provide an analysis of the Consultation-liaison psychiatry service at Groote Schuur Hospital. It was hypothesised that the hospital has a large burden of psychiatric illness amongst inpatients with unique characteristics and high rates of referrals related to HIV, alcohol and methamphetamine use. Methods. A retrospective review was performed of all inpatients referred for psychiatric consultation from other departments over a period of thirteen months. Patients referred by the emergency medical and surgical departments were excluded from this study, as they are seen by the department of emergency psychiatry. Results. A total of 452 patients (males n=174; females n=278) between the ages of 12 and 90 years were consulted, with the majority of the patients (82%, n=360) belonging to the age group of 18 to 59 years (mean age of 37 years). The referral rate to Consultation-liaison psychiatry was 0.95% (when combined with emergency psychiatry referrals the combined referral rate was 4.7%). Most referrals were from the department of medicine (56%, n=252), with the highest number of medical subspeciality referrals from neurology (6%, n=29). Request of a general review (69%) of current psychiatric symptoms (87%) occurred most frequently. The most common symptoms noted by the referring non-psychiatrist were mood symptoms (n=159; 36%), followed by suicidal behaviour (23%, n=102) and behavioural problems (21%, n=94). The mean number of psychiatric diagnoses following assessment was one (SD 1; 0:5), and most patients were assigned a definitive diagnosis (78%, n=342). Alcohol use disorder was diagnosed in 9% (n=41). Methamphetamine use was identified in 5% (n=22) of patients, with the majority being diagnosed with methamphetamine abuse. The use of other substances was identified in 9% (n=38). The HIV status was confirmed positive in 16% (n=70), with the majority of this group being female (67%). Most subjects had psychosocial and environmental problems (55%, n=249). Registrars performed a mean number of one consultation and the majority of patients were seen within 24 hours of the referral. Medication was initiated in 31% (n=139) of cases. The majority (65%, n=292) of patients were discharged from psychiatric care, and 14% (n=61) required admission to an inpatient psychiatric unit. Conclusion. The combined referral rate (consultation-liaison and emergency psychiatry) compares favourably to that of high-income countries, and is higher than any other published studies of this nature in low-income and middle-income countries. There was no substantial agreement between psychiatrist and non-psychiatrist diagnoses. As expected, mood disorders were the most common diagnoses, with only fair agreement between psychiatrist and non-psychiatrist clinicians. A high proportion of referred… Advisors/Committee Members: Hoare, Jacqueline (advisor), Louw, K (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Torline, J. R. (2016). Inpatient referrals to consultation-liaison psychiatry at a tertiary hospital in South Africa. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/23045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Torline, John Ross. “Inpatient referrals to consultation-liaison psychiatry at a tertiary hospital in South Africa.” 2016. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/23045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Torline, John Ross. “Inpatient referrals to consultation-liaison psychiatry at a tertiary hospital in South Africa.” 2016. Web. 04 Mar 2021.

Vancouver:

Torline JR. Inpatient referrals to consultation-liaison psychiatry at a tertiary hospital in South Africa. [Internet] [Thesis]. University of Cape Town; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/23045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Torline JR. Inpatient referrals to consultation-liaison psychiatry at a tertiary hospital in South Africa. [Thesis]. University of Cape Town; 2016. Available from: http://hdl.handle.net/11427/23045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

17. Stanbridge, Jessica A. Epidemiology of substance use among service users admitted to hospital following a medically serious act of deliberate self-harm: a feasibility study.

Degree: MMed, Psychiatry and Mental Health, 2019, University of Cape Town

URL: http://hdl.handle.net/11427/30854

► Background: Suicidal behaviour is increasing internationally and in South Africa and is considered a national public health problem (1). Literature has shown that substance use… (more)

▼ Background: Suicidal behaviour is increasing internationally and in South Africa and is considered a national public health problem (1). Literature has shown that substance use is a potentially modifiable risk factor for both fatal and non-fatal suicidal behavior (2- 6). In South Africa, 43 percent of patients who present to emergency departments with intentional or unintentional injuries meet the criteria for a substance use disorder (SUD) (7). The association between substance use and suicidal behavior has been well established, however, the exact nature of this relationship awaits further investigation and clarification. Aims: The proposed study’s aims are; (i)to determine the patterns of substance abuse and the prevalence of SUDs (past and current) among patients admitted following an act of DSH, (ii) to compare patterns of substance use and the prevalence of SUDs (past and current) among those admitted following an episode of DSH, those admitted to the emergency psychiatric unit for reasons other than DSH and medical patients admitted for reasons other than DSH, (iii) to determine if patterns of substance use or the diagnosis of substance use or the diagnosis of SUDs predicts hospital admission for DSH. It concurrently analyzed preliminary data in order to determine if outcomes of the larger study would be meaningful and significant. Methods: Seventy-six patients were recruited over a period of 19 weeks. Twenty-seven consecutive patients with a medically serious act of DSH were recruited and were matched with a control group based on age range and gender. Demographic data and substance use history were collected using; (i) a self reported questionnaire, (ii) Alcohol Use Disorders Identification Tests (AUDIT), (iii) Drug Use Disorders Identification Test (DUDIT) and (iv) SUD module of the structured clinical interview of the DSM. Results: Findings of the feasibility study indicated low recruitment numbers and data collection challenges. Causes of low recruitment number were multifactorial, including low base rates for self-harm, length of recruitment time, consenting capacity, tight control criteria, exclusion of manic and psychotic patients and declining of patients to participate. Data collection faced challenges including difficult navigation of hospital premises, long data collection times, limited understanding of questions, language barriers and lack of privacy. Formal suicide risk assessment was a challenge for some data collectors. Preliminary data confirmed that substance use is a significant risk factor for DSH. Conclusions: This feasibility study demonstrated the existing protocol can be used to generate meaningful data and identified specific steps to be altered in a scaled-up study. These steps included; expansion of study sites to more institutions to increase recruitment numbers, a wider range in matching criteria for control groups and improved orientation and training of data collectors regarding use of the data collection tool, navigation of the hospital premises, maintaining confidentiality and… Advisors/Committee Members: Lewis, Ian (advisor), Bantjes, Jason (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stanbridge, J. A. (2019). Epidemiology of substance use among service users admitted to hospital following a medically serious act of deliberate self-harm: a feasibility study. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/30854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stanbridge, Jessica A. “Epidemiology of substance use among service users admitted to hospital following a medically serious act of deliberate self-harm: a feasibility study.” 2019. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/30854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stanbridge, Jessica A. “Epidemiology of substance use among service users admitted to hospital following a medically serious act of deliberate self-harm: a feasibility study.” 2019. Web. 04 Mar 2021.

Vancouver:

Stanbridge JA. Epidemiology of substance use among service users admitted to hospital following a medically serious act of deliberate self-harm: a feasibility study. [Internet] [Thesis]. University of Cape Town; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/30854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stanbridge JA. Epidemiology of substance use among service users admitted to hospital following a medically serious act of deliberate self-harm: a feasibility study. [Thesis]. University of Cape Town; 2019. Available from: http://hdl.handle.net/11427/30854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Starke, Jonathan Alan. Effects of bipolar disorder on intrinsic brain networks.

Degree: Image, Psychiatry and Mental Health, 2016, University of Cape Town

URL: http://hdl.handle.net/11427/22794

► Introduction: Bipolar disorder (BD) is a brain network disorder that affects cognitive and emotional functioning, and is associated with prefrontal and/or limbic dysfunction. Functional Magnetic… (more)

▼ Introduction: Bipolar disorder (BD) is a brain network disorder that affects cognitive and emotional functioning, and is associated with prefrontal and/or limbic dysfunction. Functional Magnetic Resonance Imaging (fMRI) allows identification of intrinsic brain networks (IBN), like the default mode network (DMN) and executive control network (ECN), which are consistent with previously established functional and anatomical relationships within the brain. Analysing the functional connectivity (integrity, extent and inter-relationships) of these networks, allows a deeper understanding of brain function in health and disease. In BD, there are functional connectivity changes in the DMN, ECN and cerebellar network (CERN). We evaluate IBN in BD, to explore changes in the functional connectivity between the cerebellum, fronto-cortical and paralimbic regions. Methods: Data from 14 BD subjects and 10 control subjects was analysed after fMRI. Changes were evaluated in 3 IBN (DMN, ECN and CERN) using an FMRIB Software Library (FSL) pipeline: MELODIC/ICA-AROMA, dual-regression, randomise and Local False Discovery Rate (FDR) to identify changes in functional connectivity bipolar subjects compared to controls. Results: Subjects with BD showed decreased connectivity between the CERN and a cluster in the right precuneus; and between the ECN and a cluster in the left OFC. There was also increased connectivity between the ECN and a cluster in the left temporal pole. No connectivity changes involving the DMN were identified. Voxels within the clusters were significant at p < 0.05 with local FDR. Peaks within the clusters remained significant after further Bonferroni correction for multiple comparisons (p < 0.017). Conclusion: The finding of altered functional connectivity in BD, in networks and regions involved in cognitive/emotional processes, highlights its complex neurobiology, and suggests that abnormal connectivity may help to explain the clinical picture. These findings should be replicated with larger samples, but may represent a further advance in understanding the role of functional connectivity in the pathology of BD, and contribute to laying the foundation for functional neuroimaging as a diagnostic tool in psychiatry. Advisors/Committee Members: Horn, Neil (advisor), Beckmann, Christian (advisor).

Subjects/Keywords: Psychiatry

11 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Starke, J. A. (2016). Effects of bipolar disorder on intrinsic brain networks. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/22794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Starke, Jonathan Alan. “Effects of bipolar disorder on intrinsic brain networks.” 2016. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/22794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Starke, Jonathan Alan. “Effects of bipolar disorder on intrinsic brain networks.” 2016. Web. 04 Mar 2021.

Vancouver:

Starke JA. Effects of bipolar disorder on intrinsic brain networks. [Internet] [Thesis]. University of Cape Town; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/22794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Starke JA. Effects of bipolar disorder on intrinsic brain networks. [Thesis]. University of Cape Town; 2016. Available from: http://hdl.handle.net/11427/22794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

19. Planting, Talia. Caulrophobia: An investigation of clinical features.

Degree: MMed, Psychiatry and Mental Health, 2019, University of Cape Town

URL: http://hdl.handle.net/11427/30773

► Background: Coulrophobia describes the experience of significant distress, fear and/ or revulsion when exposed to the image and/or person of a clown (Stevenson, 2010). It… (more)

▼ Background: Coulrophobia describes the experience of significant distress, fear and/ or revulsion when exposed to the image and/or person of a clown (Stevenson, 2010). It may start in childhood and continue into adulthood (Spratley, 2009). There is limited scientific literature on this topic despite multiple online support groups attesting to the reality of this condition. Methods: Data collection using a self-administered online questionnaire from Surveymonkey was made available via a link on the larger of these online support groups on Facebook. It explored socio-demographic information and symptom phenomenology -symptom severity, course, duration, comorbid illnesses, and extent of psychological distress and functional impairment - in individuals who self-report coulrophobia. Fear of clowns is more commonly associated with fear (45.3%) than disgust (37.9%). The possibility that fear of clowns comprises a specific phobia was also examined. Those from the fear predominant group are also more likely to fulfill DSM-5 criteria for specific phobia. Extent of psychological distress and functional impairment were measured and compared to symptom severity and duration. Results: There were 95 respondents to the online survey, of which 79 were female and 16 male showing it to be more common in females. The mean age of participants was 39.82 ±12.60 years, mean age of symptom onset 9.02 ±6.12 years and mean duration of 30.44 ±12.94years. It appears to have a chronic course from onset with 30.53% identifying a specific trigger and 22.11% a positive family history of coulrophobia. It is more commonly associated with fear than disgust (45.3%). Those from the fear predominant group are also more likely to fulfill DSM-5 criteria for specific phobia. The most common comorbid disorders are major depressive disorder, obsessive compulsive disorder, panic disorder and social anxiety disorder. Use of the Kessler Psychological Distress Scale indicated a significant level of psychological distress associated with coulrophobia. The greatest area of impairment in coulrophobia was in social functioning, measured by the Sheehan Disability Scale Functional impairment was strongly associated with severity of symptoms, but not with symptom duration. Conclusion: Coulrophobia is a phenomenon that warrants clinical attention, as it is associated with significant comorbidity, psychological distress, and impaired functioning. Advisors/Committee Members: Stein, Dan J (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Planting, T. (2019). Caulrophobia: An investigation of clinical features. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/30773

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Planting, Talia. “Caulrophobia: An investigation of clinical features.” 2019. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/30773.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Planting, Talia. “Caulrophobia: An investigation of clinical features.” 2019. Web. 04 Mar 2021.

Vancouver:

Planting T. Caulrophobia: An investigation of clinical features. [Internet] [Thesis]. University of Cape Town; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/30773.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Planting T. Caulrophobia: An investigation of clinical features. [Thesis]. University of Cape Town; 2019. Available from: http://hdl.handle.net/11427/30773

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

20. Reid, Kirsten. Prevalence and correlates of anxiety disorders in psychotic illness.

Degree: Image, Psychiatry and Mental Health, 2017, University of Cape Town

URL: http://hdl.handle.net/11427/27379

► Background: Comorbid anxiety disorders in psychotic illness are reported in the international literature as highly prevalent and have a significant negative impact on patient outcomes.… (more)

▼ Background: Comorbid anxiety disorders in psychotic illness are reported in the international literature as highly prevalent and have a significant negative impact on patient outcomes. Local literature describing such comorbidity in the South African population is limited and clinically, anxiety symptoms are seldom recognised or treated in patients with psychotic disorders. More data on prevalence rates across psychotic disorder diagnoses, as well as sociodemographic correlates would aid recognition, diagnosis, and treatment, and potentially improve clinical outcomes in this population. Method: We performed a secondary analysis of an existing database which comprised data from participants of three previous studies. The sample was made up of patients from Valkenberg Hospital and healthcare facilities in its catchment area. All patients had a diagnosis of a psychotic disorder. Socio-demographic information was collected using a structured questionnaire. Clinical information and diagnosis was determined using the Structured Clinical Interview for DSM (SCID-I). Rates of comorbid anxiety disorders were compared across various sociodemographic categories. Results: The overall prevalence of any anxiety disorder in the entire sample (N=226) was 14.6% (n=33), 95% CI [10.27-19.89%]. The most common anxiety disorder comorbidities were, in descending order, panic disorder (n=12, 5.31%; 95% CI [2.77-9.09%]), PTSD (n=9, 3.98%; 95% CI [1.84-7.42%]), specific phobia (n=7, 3.10%; 95% CI [1.25-6.28%]), anxiety disorder not otherwise specified (n=7, 3.10%; 95% CI [1.25-6.28%]), social phobia (n=4, 1.77%; 95% CI [0.48%-4.47%]), generalised anxiety disorder (n=4, 1.77%; 95% CI [0.48-4.47%]), substance-induced anxiety disorder (n=4, 1.77%; 95% CI [0.48-4.47%]) and obsessive compulsive disorder (n=2, 0.88%; 95% CI [0.11-3.16%]). There was a significant association between diagnosis and the presence of post-traumatic stress disorder (PTSD), with the schizoaffective disorder group having a higher rate of PTSD (13.3% vs. 3.3% in schizophrenia, 3.2% in substance-induced mood/psychotic disorder and 0% in bipolar I disorder) (Fisher's exact test, p=0.039). In turn, there was a trend level association between diagnosis and the presence of panic disorder (PD), with schizoaffective disorder patients having higher rates of PD (16.6% vs. 4.1% in schizophrenia spectrum, 3.2% in substance-induced mood/psychotic disorder and 2.2% in bipolar I disorder) (Fisher's exact test, p=0.052). A significant association was found between level of education and the presence of PTSD, with higher rates of PTSD in patients with seven or less years of education (8.8%) compared to lower rates in those with 8-12 years of education (5.3%) and > 12years of education (0%) (Fisher's exact test, p=0.020). Conclusion: The overall prevalence of anxiety disorders in psychotic illness was lower than what has been described in previous literature. Prevalence rates of individual anxiety disorders were also lower than previously published literature. Possible reasons for this… Advisors/Committee Members: Milligan, Peter D (advisor), Temmingh, Henk (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reid, K. (2017). Prevalence and correlates of anxiety disorders in psychotic illness. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/27379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reid, Kirsten. “Prevalence and correlates of anxiety disorders in psychotic illness.” 2017. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/27379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reid, Kirsten. “Prevalence and correlates of anxiety disorders in psychotic illness.” 2017. Web. 04 Mar 2021.

Vancouver:

Reid K. Prevalence and correlates of anxiety disorders in psychotic illness. [Internet] [Thesis]. University of Cape Town; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/27379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reid K. Prevalence and correlates of anxiety disorders in psychotic illness. [Thesis]. University of Cape Town; 2017. Available from: http://hdl.handle.net/11427/27379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

21. Yorke, Neil. Systematic review of imaging studies in the lateral orbitofrontal circuit in bipolar type I disorder.

Degree: Image, Psychiatry and Mental Health, 2013, University of Cape Town

URL: http://hdl.handle.net/11427/10748

► The aim of this study was to review the available published structural magnetic resonance imaging (MRI) data in bipolar type I disorder, looking for any… (more)

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yorke, N. (2013). Systematic review of imaging studies in the lateral orbitofrontal circuit in bipolar type I disorder. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/10748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yorke, Neil. “Systematic review of imaging studies in the lateral orbitofrontal circuit in bipolar type I disorder.” 2013. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/10748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yorke, Neil. “Systematic review of imaging studies in the lateral orbitofrontal circuit in bipolar type I disorder.” 2013. Web. 04 Mar 2021.

Vancouver:

Yorke N. Systematic review of imaging studies in the lateral orbitofrontal circuit in bipolar type I disorder. [Internet] [Thesis]. University of Cape Town; 2013. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/10748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yorke N. Systematic review of imaging studies in the lateral orbitofrontal circuit in bipolar type I disorder. [Thesis]. University of Cape Town; 2013. Available from: http://hdl.handle.net/11427/10748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Shelly, James Bradly. Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study.

Degree: Image, Psychiatry and Mental Health, 2015, University of Cape Town

URL: http://hdl.handle.net/11427/16725

► Objective: To determine the occurrence and associations of Schneiderian first-rank symptoms in patients diagnosed with schizophrenia and methamphetamine psychosis using structured clinical interviews for DSM-IV… (more)

▼ Objective: To determine the occurrence and associations of Schneiderian first-rank symptoms in patients diagnosed with schizophrenia and methamphetamine psychosis using structured clinical interviews for DSM-IV (SCID-I). Method: Data from SCID-I interviews collected on two samples of patients, diagnosed with schizophrenia and with methamphetamine psychosis, as part of two separate research projects, was retrieved from the respective databases and compared. The two groups were compared on the presence of any one first rank symptom, those who had two first-rank symptoms, and those who had more than two first-rank symptoms. We calculated the prevalence of different first-rank symptoms in schizophrenia and methamphetamine psychosis. We further performed a logistic regression and calculated adjusted and unadjusted odds ratios for the association between first-rank symptoms and diagnosis. Results: One hundred and two patients fulfilled inclusion criteria for the study, 33 from the methamphetamine psychosis sample, and 69 from the schizophrenia sample. Prevalence of one, two, and more than two first-rank symptoms in the methamphetamine psychosis and schizophrenia groups was calculated as 69.6% and 69.7%, 21.2% and 20.3 %, and 27.3% and 27.5% respectively. After adjusting for covariates, thought broadcasting occurred significantly more often in patients with schizophrenia compared to those with methamphetamine psychosis (Odds ratio=3.61; 95% CI: 1.26-10.33; p<0.05). In turn, the odds of having auditory hallucinations in the form of voices conversing was significantly lower in patients with schizophrenia compared to those with methamphetamine psychosis (Odds ratio=0.27; 95% CI: 0.1-0.75; p<0.05). We found no significant association between any other first-rank symptoms as measured by the SCID-I and a diagnosis of schizophrenia or methamphetamine psychosis. Conclusion: The symptom of thought broadcasting was significantly more likely to occur in patients diagnosed with schizophrenia than in patients diagnosed with methamphetamine psychosis. Auditory hallucinations of voices heard conversing was significantly less likely to occur in patients with schizophrenia than in those with methamphetamine psychosis. Overall, there was a significant overlap of first-rank symptoms and a diagnosis of either schizophrenia or methamphetamine psychosis, but this study did not show that patients with a diagnosis of schizophrenia are more likely to have first-rank symptoms when compared to those with methamphetamine psychosis. Advisors/Committee Members: Temmingh, Henk (advisor).

Subjects/Keywords: Psychiatry

15 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shelly, J. B. (2015). Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/16725

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shelly, James Bradly. “Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study.” 2015. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/16725.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shelly, James Bradly. “Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study.” 2015. Web. 04 Mar 2021.

Vancouver:

Shelly JB. Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study. [Internet] [Thesis]. University of Cape Town; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/16725.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shelly JB. Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study. [Thesis]. University of Cape Town; 2015. Available from: http://hdl.handle.net/11427/16725

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

23. Maharaj, Avani. A retrospective audit comparing state patients with schizophrenia and bipolar mood disorder who have committed violent crime admitted to the male forensic unit at Valkenberg Hospital.

Degree: MMed, Psychiatry and Mental Health, 2018, University of Cape Town

URL: http://hdl.handle.net/11427/31140

► Background There is a consensus that psychosis confers a modest risk toward violent offending. Most research to date has shown that a statistical relationship does… (more)

▼ Background There is a consensus that psychosis confers a modest risk toward violent offending. Most research to date has shown that a statistical relationship does exist between schizophrenia and bipolar disorder, and violence and aggressive behavior In forensic mental health, state patients are rehabilitated in a general program regardless of diagnosis. It is not known whether different rehabilitation management strategies should be implemented on those with bipolar disorder as compared to those with schizophrenia. This study is an attempt to ascertain if there are differences between those diagnosed with schizophrenia and bipolar disorders, and if so, whether these have implications for their rehabilitation programs. Objectives The study aims to compare the demographic profiles and comorbidities (in terms of substance use and personality disorders) of state patients with bipolar disorder and schizophrenia who have offended violently. Methods This was a quantitative, cross sectional study. State patients who were diagnosed with schizophrenia and bipolar disorder and committed a violent crime were included in the study from the 1st January 2000 to 31st December 2014. The study population comprised a total of 93 male state patients. Of these 46 patients had a diagnosis of bipolar disorder and 47 patients had a diagnosis of schizophrenia. Results The results show that in general the differences between the schizophrenia group and the bipolar disorder group are marginal. A higher percentage of patients with schizophrenia committed murder at 17.02% and attempted murder at 12.77%. The bipolar disorder group had a significantly higher number of patients diagnosed with co morbid personality disorder at 59.57% (p value of 0.01.) Substance abuse was common in both groups. The mean age at admission was 31,23 years in schizophrenia and 36,85 years in bipolar disorder. This demonstrates an earlier onset of criminality in the group with schizophrenia. Patients with bipolar disorder were more likely to be married (13.04%), divorced (10.8%) or separated (2.17%). Conclusion There were no major differences elicited between the 2 groups of patients. Certain aspects such as therapeutic programs for personality disordered patients and social interventions in patients with poor social support would contribute to improving the quality of the rehabilitation programs currently used. The commonalities found in the 2 groups suggest that a common approach to rehabilitation would be adequate in this setting. Advisors/Committee Members: Kaliski, Sean (advisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maharaj, A. (2018). A retrospective audit comparing state patients with schizophrenia and bipolar mood disorder who have committed violent crime admitted to the male forensic unit at Valkenberg Hospital. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maharaj, Avani. “A retrospective audit comparing state patients with schizophrenia and bipolar mood disorder who have committed violent crime admitted to the male forensic unit at Valkenberg Hospital.” 2018. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/31140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maharaj, Avani. “A retrospective audit comparing state patients with schizophrenia and bipolar mood disorder who have committed violent crime admitted to the male forensic unit at Valkenberg Hospital.” 2018. Web. 04 Mar 2021.

Vancouver:

Maharaj A. A retrospective audit comparing state patients with schizophrenia and bipolar mood disorder who have committed violent crime admitted to the male forensic unit at Valkenberg Hospital. [Internet] [Thesis]. University of Cape Town; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/31140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maharaj A. A retrospective audit comparing state patients with schizophrenia and bipolar mood disorder who have committed violent crime admitted to the male forensic unit at Valkenberg Hospital. [Thesis]. University of Cape Town; 2018. Available from: http://hdl.handle.net/11427/31140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

24. Vermaak, John-Randel. A cross-sectional study of the association between cognitive impairment and haemoglobin levels in HIV-infected South Africans established on antiretroviral therapy.

Degree: MMed, Psychiatry and Mental Health, 2019, University of Cape Town

URL: http://hdl.handle.net/11427/30982

► Background Sub-Saharan Africa, the epicenter of the global population of people living with HIV (PLHIV), is estimated to have more than 25 million PLHIV. In… (more)

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vermaak, J. (2019). A cross-sectional study of the association between cognitive impairment and haemoglobin levels in HIV-infected South Africans established on antiretroviral therapy. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/30982

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vermaak, John-Randel. “A cross-sectional study of the association between cognitive impairment and haemoglobin levels in HIV-infected South Africans established on antiretroviral therapy.” 2019. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/30982.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vermaak, John-Randel. “A cross-sectional study of the association between cognitive impairment and haemoglobin levels in HIV-infected South Africans established on antiretroviral therapy.” 2019. Web. 04 Mar 2021.

Vancouver:

Vermaak J. A cross-sectional study of the association between cognitive impairment and haemoglobin levels in HIV-infected South Africans established on antiretroviral therapy. [Internet] [Thesis]. University of Cape Town; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/30982.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vermaak J. A cross-sectional study of the association between cognitive impairment and haemoglobin levels in HIV-infected South Africans established on antiretroviral therapy. [Thesis]. University of Cape Town; 2019. Available from: http://hdl.handle.net/11427/30982

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McGill University

25. Barrett-Bernstein, Meagan. Depression and functional status in colorectal cancer patients awaiting surgery; Impact of a multimodal prehabilitation program.

Degree: MS, Department of Psychiatry, 2018, McGill University

URL: https://escholarship.mcgill.ca/downloads/h989r5400.pdf ; https://escholarship.mcgill.ca/concern/theses/rv042w25m

►

Objectifs : La dépression et la déficience fonctionnelle sont souvent observées ensemble. Alors qu'elles permettent de prédire les complications et la mortalité après une intervention… (more)

▼

Objectifs : La dépression et la déficience fonctionnelle sont souvent observées ensemble. Alors qu'elles permettent de prédire les complications et la mortalité après une intervention chirurgicale, il y a peu de recherche sur la capacité fonctionnelle (CF) des cancéreux souffrant de dépression avant chirurgie. Des exercices préopératoires (préadaptation) pourraient améliorer la CF, mais l'étendue des bénéfices sur les personnes déprimées n'ont pas encore été explores. Les objectifs principaux étaient d'évaluer le lien entre la dépression préopératoire et une piètre CF, et l'amélioration de la CF par la préadaptation des personnes déprimées. Méthodes : Une analyse secondaire a été faite sur 172 patients atteints de cancer colorectal et participant à trois études comparant la préadaptation à un groupe témoin (réadaptation). La CF a été évaluée grâce au test mesurant la distance marchée en six minutes (6MWT). Les symptômes psychologiques ont été déterminés par l'échelle clinique de mesure d'anxiété et de dépression (HADS). Les relations entre les symptômes psychologiques préopératoires et la CF, chez les sujets répartis en trois groupes : déprimés (HADS-D), anxieux (HADS-A) et sans symptôme (HADS-N), ont été évalués par analyse de variance et tests Chi carré. Au moyen de régression logistique, l'effet de la préadaptation sur la CF des patients déprimés a été analysé par équation d'estimation généralisée. Résultats : Les individus déprimés ont marché significativement moins (6MWT, p=0.003) et une plus grande proportion a marché <400m au niveau de référence (45%, p<0.001). La préadaptation a amélioré significativement le 6MWT du groupe HADS-D (RO=2.36, IC95% : 1.53-3.66), mais pas des groupes HADS-N (RO=0.97, IC95% : 0.44-2.16) ou HADS–A (RO=1.47, IC95% : 0.69-3.16). Conclusion : Cette étude démontre pour la première fois que les patients cancéreux déprimés ont une CF plus faible et bénéficient le plus physiquement d'un programme de préadaptation.

Objective: Depression and functional impairment frequently co-occur. Though both predict complications and mortality following surgery, there is a paucity of research examining functional status (FS) in depressed cancer patients awaiting surgery. Prehabilitation, a preoperative intervention including exercise, nutrition and stress-reducing strategies, may help to improve FS; however, the extent to which depressed individuals can benefit from this intervention has not yet been explored. The primary objectives were to assess whether preoperative depression is associated with poor FS, and whether prehabilitation can improve FS in depressed individuals. Method: A secondary analysis was conducted on 172 colorectal cancer (CRC) patients enrolled in three studies comparing prehabilitation with a control group (rehabilitation). FS was assessed with the Six-Minute Walk Test (6MWT), measuring distance walked during 6-minutes (6MWD), and the Hospital Anxiety and Depression Scale (HADS) was used to assess psychological symptoms. Measures were collected twice preoperatively, at 4-weeks…

Advisors/Committee Members: Leon Tourian (Internal/Supervisor), Franco Carli (Internal/Cosupervisor2).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barrett-Bernstein, M. (2018). Depression and functional status in colorectal cancer patients awaiting surgery; Impact of a multimodal prehabilitation program. (Masters Thesis). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/h989r5400.pdf ; https://escholarship.mcgill.ca/concern/theses/rv042w25m

Chicago Manual of Style (16^th Edition):

Barrett-Bernstein, Meagan. “Depression and functional status in colorectal cancer patients awaiting surgery; Impact of a multimodal prehabilitation program.” 2018. Masters Thesis, McGill University. Accessed March 04, 2021. https://escholarship.mcgill.ca/downloads/h989r5400.pdf ; https://escholarship.mcgill.ca/concern/theses/rv042w25m.

MLA Handbook (7^th Edition):

Barrett-Bernstein, Meagan. “Depression and functional status in colorectal cancer patients awaiting surgery; Impact of a multimodal prehabilitation program.” 2018. Web. 04 Mar 2021.

Vancouver:

Barrett-Bernstein M. Depression and functional status in colorectal cancer patients awaiting surgery; Impact of a multimodal prehabilitation program. [Internet] [Masters thesis]. McGill University; 2018. [cited 2021 Mar 04]. Available from: https://escholarship.mcgill.ca/downloads/h989r5400.pdf ; https://escholarship.mcgill.ca/concern/theses/rv042w25m.

Council of Science Editors:

Barrett-Bernstein M. Depression and functional status in colorectal cancer patients awaiting surgery; Impact of a multimodal prehabilitation program. [Masters Thesis]. McGill University; 2018. Available from: https://escholarship.mcgill.ca/downloads/h989r5400.pdf ; https://escholarship.mcgill.ca/concern/theses/rv042w25m

McGill University

26. Hadjis, Timothy. The effect of a single, minimal dose of antipsychotic on the drive to engage in social roles.

Degree: MS, Department of Psychiatry, 2018, McGill University

URL: https://escholarship.mcgill.ca/downloads/1n79h677r.pdf ; https://escholarship.mcgill.ca/concern/theses/pr76f5885

►

La motivation des individus à s'engager dans des rôles sociaux extraordinaires est un facteur important contribuant à la formation de symptômes psychotiques. Alors que les… (more)

▼

La motivation des individus à s'engager dans des rôles sociaux extraordinaires est un facteur important contribuant à la formation de symptômes psychotiques. Alors que les antipsychotiques sont largement prescrits pour traiter les symptômes psychotiques, peu d'études ont étudié leurs effets sur la motivation de jouer des rôles sociaux extraordinaires. L'objectif de la présente étude était d'examiner l'effet d'un antipsychotique atypique (olanzapine) sur la motivation des rôles sociaux extraordinaires par rapport à un antipsychotique-placebo. Cent cinq individus en bonne santé (antipsychotique-placebo, n = 51, âge moyen: 23,8 ans, 52,9% d'hommes, 2,5 mg d'olanzapine, n = 54, âge moyen: 23,07 ans, 55,5% d'hommes) ont participé à cette étude. Les participants du groupe médicamenteux actif recevaient de l'olanzapine, tandis que ceux du groupe antipsychotique-placebo recevaient une pilule inerte que l'on croyait être l'olanzapine. Tous les participants ont été informés des effets indésirables du médicament au moyen du formulaire de consentement au début de l'expérience. Tous les participants ont été présentés individuellement avec des centaines de noms de rôles sociaux dans des conditions de psychologie expérimentale en deux sessions. La tâche du participant consistait à décider s'il envisagerait ou non d'assumer ce rôle à n'importe quel moment de sa vie. Les résultats ont révélé que les participants qui prenaient l'olanzapine étaient plus lents que ceux qui prenaient le antipsychotique-placebo à accepter tous les types de rôle et à rejeter les rôles favorables extraordinaires dans la première session. Au cours de la deuxième séance, les participants prenant de l'olanzapine (vs. antipsychotique-placebo) étaient plus lents à accepter des rôles extraordinaires, mais plus rapide à rejeter des rôles défavorables ordinaires et extraordinaires. Comparé à l'antipsychotique-placebo, les participants prenant de l'olanzapine sont devenus plus rapides à accepter des rôles ordinaires et à rejeter des rôles extraordinaires. En conclusion, une seule dose minimale d'olanzapine influe la vitesse à laquelle les participants en bonne santé prennent des décisions concernant leur rôle social par rapport à un antipsychotique-placebo. L'olanzapine (vs. antipsychotique-placebo) peut donc modifier le désir pour jouer des rôles sociaux. Les résultats trouvés dans cette étude peuvent fournir de plus amples informations sur les effets des antipsychotiques sur le désir de jouer des rôles sociaux extraordinaires.

The motivation for individuals to engage in extraordinary social roles is an important factor contributing to the formation of psychotic symptoms. While antipsychotics are widely prescribed to treat psychotic symptoms, few studies have investigated their effects on the drive to engage in extraordinary social roles. Thus, the objective of the current study was to examine the effect of an atypical antipsychotic (olanzapine) on the drive to play extraordinary social roles relative to an antipsychotic-placebo. One hundred and five healthy…

Advisors/Committee Members: Jacques Bruno Debruille (Internal/Supervisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hadjis, T. (2018). The effect of a single, minimal dose of antipsychotic on the drive to engage in social roles. (Masters Thesis). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/1n79h677r.pdf ; https://escholarship.mcgill.ca/concern/theses/pr76f5885

Chicago Manual of Style (16^th Edition):

Hadjis, Timothy. “The effect of a single, minimal dose of antipsychotic on the drive to engage in social roles.” 2018. Masters Thesis, McGill University. Accessed March 04, 2021. https://escholarship.mcgill.ca/downloads/1n79h677r.pdf ; https://escholarship.mcgill.ca/concern/theses/pr76f5885.

MLA Handbook (7^th Edition):

Hadjis, Timothy. “The effect of a single, minimal dose of antipsychotic on the drive to engage in social roles.” 2018. Web. 04 Mar 2021.

Vancouver:

Hadjis T. The effect of a single, minimal dose of antipsychotic on the drive to engage in social roles. [Internet] [Masters thesis]. McGill University; 2018. [cited 2021 Mar 04]. Available from: https://escholarship.mcgill.ca/downloads/1n79h677r.pdf ; https://escholarship.mcgill.ca/concern/theses/pr76f5885.

Council of Science Editors:

Hadjis T. The effect of a single, minimal dose of antipsychotic on the drive to engage in social roles. [Masters Thesis]. McGill University; 2018. Available from: https://escholarship.mcgill.ca/downloads/1n79h677r.pdf ; https://escholarship.mcgill.ca/concern/theses/pr76f5885

McGill University

27. Jordan, Gerald. Positive change following a first episode of psychosis: a mixed methods study using a convergent design.

Degree: PhD, Department of Psychiatry, 2018, McGill University

URL: https://escholarship.mcgill.ca/downloads/sq87bw82m.pdf ; https://escholarship.mcgill.ca/concern/theses/q524jr136

► Un premier épisode psychotique (PEP) est souvent une maladie mentale grave et pénible. Cependant, un PEP peut également constituer une opportunité de changement positif. Bien… (more)

▼ Un premier épisode psychotique (PEP) est souvent une maladie mentale grave et pénible. Cependant, un PEP peut également constituer une opportunité de changement positif. Bien que des changements positifs aient été rapportés à la suite de diverses maladies physiques (tel le VIH) ou d'événements traumatiques (telle la guerre), très peu d'études ont porté sur les changements positifs pouvant suivre un PEP. Pour combler cette lacune, cette thèse aborde deux questions: 1) Quels sont les changements positifs qu'éprouvent les personnes après un PEP et 2) Quels facteurs ou processus peuvent faciliter de tels changements? Ces questions de recherche ont été abordées en synthétisant les connaissances scientifiques existantes, basées sur deux revues de la littérature (un examen de la portée et une revue systématique) et en menant une étude empirique à méthodes mixtes, divisée en deux chapitres. L'examen de la portée de la littérature a été effectué en six étapes: l'identification de la question de recherche et des études pertinentes, la sélection d'études, la présentation des données, le codage et la synthèse des résultats, et une consultation avec des parties prenantes. Toutes les données ont été décrites et soumises à une analyse thématique. La revue systématique d'études mixtes, employant une synthèse qualitative convergente, a été réalisée en cinq étapes: la formulation d'une question de revue, la définition des critères d'éligibilité, l'identification des sources d'information, l'identification et la sélection des études et l'évaluation de la qualité des études. Les données ont été analysées en utilisant une synthèse thématique. L'étude empirique des méthodes mixtes a utilisé un design convergent de méthodes mixtes, incluant une composante quantitative (n=94) et une composante qualitative (n=12). Dans la composante quantitative, les participants ont rempli des questionnaires validés évaluant les changements positifs (l'échelle Posttraumatic Growth Inventory) et les prédicteurs de changement positif (les échelles Subjective Experiences of Psychosis Scale, le Brief COPE, le Recovery Assessment Scale, le Child and Youth/Adult Resilience Measure, et le Multidimensional Scale for Perceived Social Support). Dans la composante qualitative, les individus ont participé à des entrevues semi-structurés évaluant les raisons pour lesquelles ces participants estimaient avoir reçu des services d'intervention précoce; comment ils pensent avoir changé après leur PEP; et les facteurs qu'ils perçoivent comment ayant facilité de tels changements. Les données quantitatives ont été analysées à l'aide de statistiques descriptives et de régression multiple, tandis que les données qualitatives ont été analysées à l'aide d'une analyse thématique. Les résultats des études ont révélé que les participants (y compris ceux ayant une expérience vécue de PEP eux-mêmes, ainsi que leurs familles et amis) ont vécu des changements positifs au niveau individuel (le développement d'un sentiment d'identité plus robuste, l'amélioration de la santé mentale, etc.),… Advisors/Committee Members: Ashok Malla (Supervisor1), Srividya Iyer (Supervisor2).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jordan, G. (2018). Positive change following a first episode of psychosis: a mixed methods study using a convergent design. (Doctoral Dissertation). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/sq87bw82m.pdf ; https://escholarship.mcgill.ca/concern/theses/q524jr136

Chicago Manual of Style (16^th Edition):

Jordan, Gerald. “Positive change following a first episode of psychosis: a mixed methods study using a convergent design.” 2018. Doctoral Dissertation, McGill University. Accessed March 04, 2021. https://escholarship.mcgill.ca/downloads/sq87bw82m.pdf ; https://escholarship.mcgill.ca/concern/theses/q524jr136.

MLA Handbook (7^th Edition):

Jordan, Gerald. “Positive change following a first episode of psychosis: a mixed methods study using a convergent design.” 2018. Web. 04 Mar 2021.

Vancouver:

Jordan G. Positive change following a first episode of psychosis: a mixed methods study using a convergent design. [Internet] [Doctoral dissertation]. McGill University; 2018. [cited 2021 Mar 04]. Available from: https://escholarship.mcgill.ca/downloads/sq87bw82m.pdf ; https://escholarship.mcgill.ca/concern/theses/q524jr136.

Council of Science Editors:

Jordan G. Positive change following a first episode of psychosis: a mixed methods study using a convergent design. [Doctoral Dissertation]. McGill University; 2018. Available from: https://escholarship.mcgill.ca/downloads/sq87bw82m.pdf ; https://escholarship.mcgill.ca/concern/theses/q524jr136

McGill University

28. Cassis, Tamara. The association between childhood adversity and attachment/relationship style in mood disorders.

Degree: MS, Department of Psychiatry, 2018, McGill University

URL: https://escholarship.mcgill.ca/downloads/kh04dr88x.pdf ; https://escholarship.mcgill.ca/concern/theses/9k41zg81z

► Background. Mood disorders (Major Depressive Disorder (MDD) and Bipolar Disorder Type I and Type II (BPI & BPII)) can have large negative impacts on individuals… (more)

▼ Background. Mood disorders (Major Depressive Disorder (MDD) and Bipolar Disorder Type I and Type II (BPI & BPII)) can have large negative impacts on individuals affected by them, and on the community as a whole. Childhood adversity has been found to be a risk factor for mood disorders. Additionally, childhood adversities, in the form of physical abuse and neglect, have been associated with insecure attachment styles in adulthood. Insecure attachment styles have also been found to be more prevalent in individuals with mood disorders compared to those without. The association between childhood adversity and attachment in mood disorder populations has not been well examined. Objectives. (1) To examine the prevalence and severity of different forms of childhood adversity in a clinical mood disorders population (patients with MDD, BPI or BPII). (2) To examine the prevalence of attachment styles in a clinical mood disorders population. (3A) To examine the association between different forms of childhood adversity and attachment styles in a clinical mood disorders population. (3B) To determine if mood disorder type modifies the association between childhood adversity and attachment style.Methods. This was a cross-sectional study of 230 outpatients from a university-based, tertiary-care clinic in Montreal, Quebec, with a diagnosis of MDD (N=71), BP type I (N=68), and BP type II (N=52). Psychiatric diagnoses were determined using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Childhood adversity was assessed using the Childhood Experience of Care and Abuse Questionnaire, which measures antipathy, parental loss, neglect, role reversal, and physical, psychological, and sexual abuse. Attachment styles were assessed using the Experiences in Close Relationships Questionnaire, anxious and avoidant attachment styles were examined. One-way ANOVA and Tukey post-hoc tests were conducted for continuous variables, and chi-square tests were conducted for dichotomous variables, to examine the prevalence of childhood adversities and attachment styles within each diagnostic group. Linear regressions adjusted for age and sex were used to find the association between specific types of childhood adversity and insecure attachment in the mood sample.Results. Sixty-five percent of subjects experienced at least one form of childhood adversity. Fifty-eight percent suffered from physical abuse from at least one parent, about a quarter experienced marked antipathy, neglect and psychological abuse from at least one parent (25.9%, 22.4% and 27.4%, respectively), 32.4% suffered from sexual abuse, 26.0% experienced parental death or separation, and 15.9% experienced marked role reversal. The mean attachment score was 4.0 for anxious attachment and 3.8 for avoidant attachment, with the BPII group scoring higher than the BPI group (4.5 vs. 3.7) on anxious attachment, and both the BPII and MDD groups scoring higher than the BPI group (4.0 and 4.0 vs. 3.4) on avoidant attachment. Antipathy, psychological abuse and role reversal were… Advisors/Committee Members: Nancy Low (Internal/Supervisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cassis, T. (2018). The association between childhood adversity and attachment/relationship style in mood disorders. (Masters Thesis). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/kh04dr88x.pdf ; https://escholarship.mcgill.ca/concern/theses/9k41zg81z

Chicago Manual of Style (16^th Edition):

Cassis, Tamara. “The association between childhood adversity and attachment/relationship style in mood disorders.” 2018. Masters Thesis, McGill University. Accessed March 04, 2021. https://escholarship.mcgill.ca/downloads/kh04dr88x.pdf ; https://escholarship.mcgill.ca/concern/theses/9k41zg81z.

MLA Handbook (7^th Edition):

Cassis, Tamara. “The association between childhood adversity and attachment/relationship style in mood disorders.” 2018. Web. 04 Mar 2021.

Vancouver:

Cassis T. The association between childhood adversity and attachment/relationship style in mood disorders. [Internet] [Masters thesis]. McGill University; 2018. [cited 2021 Mar 04]. Available from: https://escholarship.mcgill.ca/downloads/kh04dr88x.pdf ; https://escholarship.mcgill.ca/concern/theses/9k41zg81z.

Council of Science Editors:

Cassis T. The association between childhood adversity and attachment/relationship style in mood disorders. [Masters Thesis]. McGill University; 2018. Available from: https://escholarship.mcgill.ca/downloads/kh04dr88x.pdf ; https://escholarship.mcgill.ca/concern/theses/9k41zg81z

McGill University

29. Bhat, Venkat. Therapeutic response to methylphenidate in children with ADHD: Effect of observer/setting and gender of the observer.

Degree: MS, Department of Psychiatry, 2018, McGill University

URL: https://escholarship.mcgill.ca/downloads/9880vt238.pdf ; https://escholarship.mcgill.ca/concern/theses/02870z34j

► Contexte: Le diagnostic du trouble déficitaire de l'attention avec hyperactivité (TDAH) nécessite une synthèse de l'information obtenue à partir de diverses sources, y compris les… (more)

▼ Contexte: Le diagnostic du trouble déficitaire de l'attention avec hyperactivité (TDAH) nécessite une synthèse de l'information obtenue à partir de diverses sources, y compris les parents et les enseignants. Ce projet vise à répondre à deux questions clés relatives à réponse thérapeutique (TR) observées avec méthylphénidate (MPH) et Placebo:1.Quel est le rôle de l'observateur et le milieu de l'observation (parent, enseignant, situation simulée en classe - RASS, l'indexe CPT neuropsychologique, personnel clinique)?2.Quel est le rôle du genre de l'enfant et de l'observateur (parent, enseignant)?Méthodes:L'étude Pharmaco-comportementale et génétique du TDAH est une étude en cours à l'Hôpital Douglas à Montréal. Après une période sans médication d'une semaine, les enfants atteints de TDAH participent à un essai clinique en double-aveugle randomisé de deux semaines avec du MPH et du placebo. L'information clinique (Conner's Global Index) sur la réponse thérapeutique est obtenue auprès des enseignants (CON-T) et des parents (CON-P) pendant l'évaluation de base et pendant les deux semaines de l'essai clinique. Les enfants participent également aux tests simulées en classe, l'Échelle d'activité académique restreinte (RASS) et les tests neuropsychologiques, y compris le test de performance de Conner (CPT) qui se répètent au cours des deux semaines. L'évaluation au laboratoire est faite par des observateurs formés pour compléter une échelle clinique d'impression globale d'amélioration (CGI-I) au cours des deux semaines. Enfin, une discussion de groupe dirigé par le clinicien parvient à un consensus de réponse à la thérapie en tenant compte de toutes les informations disponibles (GIP) et avant que l'aveugle soient levé. Les scores de différence entre les semaines de traitement par methylphenidate et placebo ont été calculés pour toutes les mesures. Des corrélations de Pearson ont été effectuées pour examiner le rôle du milieu d'observation, des tests d'échantillon indépendants ont été effectués pour examiner le rôle du genre. Résultats: Pour la première question basée sur l'effet de l'observateur, les scores de base des parents et des enseignants sont significativement corrélés pour les dimensions trémoussant-impulsif (RI) et émotif-labile (EL) de l'indexe Conners' et les scores de référence du CPT « Overall Index ». Les corrélations de réponse thérapeutique sont observées chez les garçons ayant le sous-type RI. Le CPT « Overall Index », RASS, CGI-I, et GIP présentent des corrélations significatives entre elles, mais ne sont pas corrélés avec les évaluations des parents et enseignants.Pour la deuxième question explorant l'effet du genre, des interactions significatives entre le genre de l'enfant et le genre de l'enseignant sur les scores CON-T à la base et pour le traitement ont été notées. Seuls les effets principaux du genre de l'enfant et du genre des parents au cours de l'évaluation de base ont été notés sur le CON-P. Aucune différence significative entre les sexes n'a été observée pour CPT « Overall Index », RASS,… Advisors/Committee Members: Ridha Joober (Internal/Supervisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhat, V. (2018). Therapeutic response to methylphenidate in children with ADHD: Effect of observer/setting and gender of the observer. (Masters Thesis). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/9880vt238.pdf ; https://escholarship.mcgill.ca/concern/theses/02870z34j

Chicago Manual of Style (16^th Edition):

Bhat, Venkat. “Therapeutic response to methylphenidate in children with ADHD: Effect of observer/setting and gender of the observer.” 2018. Masters Thesis, McGill University. Accessed March 04, 2021. https://escholarship.mcgill.ca/downloads/9880vt238.pdf ; https://escholarship.mcgill.ca/concern/theses/02870z34j.

MLA Handbook (7^th Edition):

Bhat, Venkat. “Therapeutic response to methylphenidate in children with ADHD: Effect of observer/setting and gender of the observer.” 2018. Web. 04 Mar 2021.

Vancouver:

Bhat V. Therapeutic response to methylphenidate in children with ADHD: Effect of observer/setting and gender of the observer. [Internet] [Masters thesis]. McGill University; 2018. [cited 2021 Mar 04]. Available from: https://escholarship.mcgill.ca/downloads/9880vt238.pdf ; https://escholarship.mcgill.ca/concern/theses/02870z34j.

Council of Science Editors:

Bhat V. Therapeutic response to methylphenidate in children with ADHD: Effect of observer/setting and gender of the observer. [Masters Thesis]. McGill University; 2018. Available from: https://escholarship.mcgill.ca/downloads/9880vt238.pdf ; https://escholarship.mcgill.ca/concern/theses/02870z34j

McGill University

30. Farella, Maria. Expressing writing with adolescents: revealing secrets what's really going on?.

Degree: MS, Department of Psychiatry, 2018, McGill University

URL: https://escholarship.mcgill.ca/downloads/5425kd04v.pdf ; https://escholarship.mcgill.ca/concern/theses/h128nh09r

► RésuméCette thèse examine les processus émotionnels, psychologiques et cognitifs complexes d'une intervention d'expression écrite (EC) dont des adolescents font l'expérience dans un cadre scolaire. Plus… (more)

▼ RésuméCette thèse examine les processus émotionnels, psychologiques et cognitifs complexes d'une intervention d'expression écrite (EC) dont des adolescents font l'expérience dans un cadre scolaire. Plus spécifiquement, son objectif premier est l'évaluation de journaux à la recherche d'éléments d'hypothèses récurrentes avancées dans la littérature pour expliquer le pourquoi et le comment du fonctionnement de l'EC en répondant à deux interrogations clés : Quels sont les processus émotionnels, psychologiques et cognitifs impliqués dans l'EC, et comment est-ce que ces processus se reflètent dans les journaux des étudiants durant l'intervention d'EC ? L'étude sur le terrain s'est étendue sur quatre semaines, et les données ont été générées au moyen d'un échantillonnage aléatoire de journaux d'étudiants. L'analyse des données combine une approche thématique analytique inductive à une approche conceptuelle analytique déductive afin de comprendre les journaux des étudiants et comporte l'exploration de chaque journal au moyen de 8 théories sur les mécanismes sous-jacents du fonctionnement de l'EC dans la mesure où ils ont un impact sur les adolescents. Les résultats de la classification thématique effectuée dans le cadre de cette étude montrent que 3 des 5 hypothèses avancées dans la littérature sur les mécanismes sous-jacents présumés sont apparues dans les journaux des étudiants avec les résultats suivants : la plus robuste a été l'hypothèse de la régulation émotionnelle /autorégulation; l'hypothèse de l'adaptation occupait le troisième rang; et le traitement cognitif, le quatrième. De plus, deux des hypothèses avancées par l'auteur (non récurrentes dans la littérature) ont été vérifiées avec l'autonomisation au deuxième rang et l'hypothèse du bien-être au cinquième rang. Aussi, la classification thématique inductive a montré que les trois thèmes se dégageant le plus souvent dans les journaux des étudiants touchaient les capacités des étudiants à : (a) favoriser des perspectives saines/des perceptions positives accrues; (b) appliquer les enseignements des interventions dans d'autres contextes; et (c) réfléchir à la façon dont leur expérience peut influer sur les autres après la conclusion de l'intervention d'EC. Les conclusions de cette étude illustrent que ces observations appuient l'idée que les hypothèses de processus cognitif, de régulation émotionnelle /autorégulation et d'adaptation (que l'on retrouve toutes dans la littérature antérieure) ainsi que l'hypothèse de l'autonomisation et celle du bien-être (proposées par l'auteur de cette étude) peuvent représenter des mécanismes sous-jacents importants pouvant contribuer à expliquer la façon dont l'EC influe sur les états mentaux des adolescents. De plus, les conclusions de cette étude sont à l'effet que même si dans le cadre de cette étude des éléments appuyant des hypothèses de désinhibition des émotions, d'exposition/habituation ou de constructivisme ne sont pas apparus dans l'analyse, l'absence de résultats est probablement la conséquence de la méthodologie… Advisors/Committee Members: Danielle Groleau (Internal/Supervisor).

Subjects/Keywords: Psychiatry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farella, M. (2018). Expressing writing with adolescents: revealing secrets what's really going on?. (Masters Thesis). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/5425kd04v.pdf ; https://escholarship.mcgill.ca/concern/theses/h128nh09r

Chicago Manual of Style (16^th Edition):

Farella, Maria. “Expressing writing with adolescents: revealing secrets what's really going on?.” 2018. Masters Thesis, McGill University. Accessed March 04, 2021. https://escholarship.mcgill.ca/downloads/5425kd04v.pdf ; https://escholarship.mcgill.ca/concern/theses/h128nh09r.

MLA Handbook (7^th Edition):

Farella, Maria. “Expressing writing with adolescents: revealing secrets what's really going on?.” 2018. Web. 04 Mar 2021.

Vancouver:

Farella M. Expressing writing with adolescents: revealing secrets what's really going on?. [Internet] [Masters thesis]. McGill University; 2018. [cited 2021 Mar 04]. Available from: https://escholarship.mcgill.ca/downloads/5425kd04v.pdf ; https://escholarship.mcgill.ca/concern/theses/h128nh09r.

Council of Science Editors:

Farella M. Expressing writing with adolescents: revealing secrets what's really going on?. [Masters Thesis]. McGill University; 2018. Available from: https://escholarship.mcgill.ca/downloads/5425kd04v.pdf ; https://escholarship.mcgill.ca/concern/theses/h128nh09r

Open Access Theses and Dissertations