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University: University of Washington

You searched for subject:(Protein chemistry). Showing records 1 – 25 of 25 total matches.

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University of Washington

1. Anderson, Jordan Micheal. Caps - Turns - Loops: Designing Better β-Hairpins.

Degree: PhD, 2017, University of Washington

 As protein engineering promises advances in almost every field of science and medicine, a greater understanding of the protein folding problem is necessary to make… (more)

Subjects/Keywords: NMR; Peptide; Protein Design; Protein Folding; β-Hairpin; β-Sheet; Chemistry; Biochemistry; Organic chemistry; Chemistry

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APA (6th Edition):

Anderson, J. M. (2017). Caps - Turns - Loops: Designing Better β-Hairpins. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/40518

Chicago Manual of Style (16th Edition):

Anderson, Jordan Micheal. “Caps - Turns - Loops: Designing Better β-Hairpins.” 2017. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/40518.

MLA Handbook (7th Edition):

Anderson, Jordan Micheal. “Caps - Turns - Loops: Designing Better β-Hairpins.” 2017. Web. 17 Jun 2019.

Vancouver:

Anderson JM. Caps - Turns - Loops: Designing Better β-Hairpins. [Internet] [Doctoral dissertation]. University of Washington; 2017. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/40518.

Council of Science Editors:

Anderson JM. Caps - Turns - Loops: Designing Better β-Hairpins. [Doctoral Dissertation]. University of Washington; 2017. Available from: http://hdl.handle.net/1773/40518


University of Washington

2. Hari, Sanjay Baju. Investigating Inactive Conformations of Protein Kinases.

Degree: PhD, 2013, University of Washington

Protein kinases comprise a substantial fraction of the human genome and constitute a wide array of cell signaling pathways that control countless cellular processes. Improper… (more)

Subjects/Keywords: Enzyme; Kinase; Protein; Signaling; Chemistry; Biochemistry; Biophysics; chemistry

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APA (6th Edition):

Hari, S. B. (2013). Investigating Inactive Conformations of Protein Kinases. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/24153

Chicago Manual of Style (16th Edition):

Hari, Sanjay Baju. “Investigating Inactive Conformations of Protein Kinases.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/24153.

MLA Handbook (7th Edition):

Hari, Sanjay Baju. “Investigating Inactive Conformations of Protein Kinases.” 2013. Web. 17 Jun 2019.

Vancouver:

Hari SB. Investigating Inactive Conformations of Protein Kinases. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/24153.

Council of Science Editors:

Hari SB. Investigating Inactive Conformations of Protein Kinases. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/24153


University of Washington

3. Lin, Yu-Ru. Insight from designing ideal αβ monomers and homo-oligomers.

Degree: PhD, 2017, University of Washington

 Previously, general principles relating secondary structure patterns to tertiary packing motifs enable design of different protein topologies stabilized by consistent local and non-local interactions. With… (more)

Subjects/Keywords: De novo protein; Protein Design; Rosetta Design; Biochemistry; Molecular biology; Nanoscience; Biological chemistry

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APA (6th Edition):

Lin, Y. (2017). Insight from designing ideal αβ monomers and homo-oligomers. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/39956

Chicago Manual of Style (16th Edition):

Lin, Yu-Ru. “Insight from designing ideal αβ monomers and homo-oligomers.” 2017. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/39956.

MLA Handbook (7th Edition):

Lin, Yu-Ru. “Insight from designing ideal αβ monomers and homo-oligomers.” 2017. Web. 17 Jun 2019.

Vancouver:

Lin Y. Insight from designing ideal αβ monomers and homo-oligomers. [Internet] [Doctoral dissertation]. University of Washington; 2017. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/39956.

Council of Science Editors:

Lin Y. Insight from designing ideal αβ monomers and homo-oligomers. [Doctoral Dissertation]. University of Washington; 2017. Available from: http://hdl.handle.net/1773/39956


University of Washington

4. Frenz, Brandon Michael. Advances In Computer Aided Protein Structure Determination From Sparse Cryo Electron Microscopy Data.

Degree: PhD, 2018, University of Washington

 Single-particle cryo-electron microscopy (cryoEM) has become a powerful tool for determining macromolecular structures. Thanks to recent advances in direct electron detectors and motion correction algorithms… (more)

Subjects/Keywords: Computational Protein Modeling; Cryo electron microscopy; Glycans; Protein Refinement; Rosetta; Biochemistry; Biological chemistry

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APA (6th Edition):

Frenz, B. M. (2018). Advances In Computer Aided Protein Structure Determination From Sparse Cryo Electron Microscopy Data. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/40847

Chicago Manual of Style (16th Edition):

Frenz, Brandon Michael. “Advances In Computer Aided Protein Structure Determination From Sparse Cryo Electron Microscopy Data.” 2018. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/40847.

MLA Handbook (7th Edition):

Frenz, Brandon Michael. “Advances In Computer Aided Protein Structure Determination From Sparse Cryo Electron Microscopy Data.” 2018. Web. 17 Jun 2019.

Vancouver:

Frenz BM. Advances In Computer Aided Protein Structure Determination From Sparse Cryo Electron Microscopy Data. [Internet] [Doctoral dissertation]. University of Washington; 2018. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/40847.

Council of Science Editors:

Frenz BM. Advances In Computer Aided Protein Structure Determination From Sparse Cryo Electron Microscopy Data. [Doctoral Dissertation]. University of Washington; 2018. Available from: http://hdl.handle.net/1773/40847


University of Washington

5. Haydon, Ian. De novo protein fusions as platforms for enzyme design.

Degree: 2019, University of Washington

 Control over enzymatic catalysis is a central goal of biotechnology. Recent advances in computational protein design are beginning to allow for the de novo creation… (more)

Subjects/Keywords: computational biology; enzymes; protein design; protein engineering; Biochemistry; Bioengineering; Biophysics; Biological chemistry

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APA (6th Edition):

Haydon, I. (2019). De novo protein fusions as platforms for enzyme design. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/43305

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Haydon, Ian. “De novo protein fusions as platforms for enzyme design.” 2019. Thesis, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43305.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Haydon, Ian. “De novo protein fusions as platforms for enzyme design.” 2019. Web. 17 Jun 2019.

Vancouver:

Haydon I. De novo protein fusions as platforms for enzyme design. [Internet] [Thesis]. University of Washington; 2019. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43305.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haydon I. De novo protein fusions as platforms for enzyme design. [Thesis]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/43305

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Washington

6. Xue, Chang. Method Development for Qualitative and Quantitative Study in Mass Spectrometry.

Degree: PhD, 2014, University of Washington

 Mass spectrometry has become the method of choice for lots of areas in recent years including protein study and clinical research. In this thesis, work… (more)

Subjects/Keywords: chemical derivatization; clinical research; de novo sequencing; electron transfer dissociation; mass spectrometry; protein protein interaction; Chemistry; chemistry

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APA (6th Edition):

Xue, C. (2014). Method Development for Qualitative and Quantitative Study in Mass Spectrometry. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/25465

Chicago Manual of Style (16th Edition):

Xue, Chang. “Method Development for Qualitative and Quantitative Study in Mass Spectrometry.” 2014. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/25465.

MLA Handbook (7th Edition):

Xue, Chang. “Method Development for Qualitative and Quantitative Study in Mass Spectrometry.” 2014. Web. 17 Jun 2019.

Vancouver:

Xue C. Method Development for Qualitative and Quantitative Study in Mass Spectrometry. [Internet] [Doctoral dissertation]. University of Washington; 2014. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/25465.

Council of Science Editors:

Xue C. Method Development for Qualitative and Quantitative Study in Mass Spectrometry. [Doctoral Dissertation]. University of Washington; 2014. Available from: http://hdl.handle.net/1773/25465


University of Washington

7. Andrews, Simeon. Label Transfer Reagents for the Investigation of Protein Kinase Complexes.

Degree: PhD, 2013, University of Washington

Protein kinases are essential enzymes for cellular signaling, and are often regulated by participation in protein complexes. The mitogen-activated protein kinase (MAPK) p38 is involved… (more)

Subjects/Keywords: biological chemistry; click chemistry; kinase; label transfer reagent; p38; protein complex tool; Biochemistry; Organic chemistry; Chemistry

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APA (6th Edition):

Andrews, S. (2013). Label Transfer Reagents for the Investigation of Protein Kinase Complexes. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/21746

Chicago Manual of Style (16th Edition):

Andrews, Simeon. “Label Transfer Reagents for the Investigation of Protein Kinase Complexes.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/21746.

MLA Handbook (7th Edition):

Andrews, Simeon. “Label Transfer Reagents for the Investigation of Protein Kinase Complexes.” 2013. Web. 17 Jun 2019.

Vancouver:

Andrews S. Label Transfer Reagents for the Investigation of Protein Kinase Complexes. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/21746.

Council of Science Editors:

Andrews S. Label Transfer Reagents for the Investigation of Protein Kinase Complexes. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/21746


University of Washington

8. Richter, Florian. Computational de-novo design of ester hydrolases.

Degree: PhD, 2013, University of Washington

 Computational protein design is a relatively new technique used to devise amino acid sequences to fold into proteins having novel structures or functions. Here, we… (more)

Subjects/Keywords: catalysis; computational protein design; enzyme design; hydrolysis; synthetic biology; Biochemistry; Chemistry; Biological chemistry

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APA (6th Edition):

Richter, F. (2013). Computational de-novo design of ester hydrolases. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/21829

Chicago Manual of Style (16th Edition):

Richter, Florian. “Computational de-novo design of ester hydrolases.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/21829.

MLA Handbook (7th Edition):

Richter, Florian. “Computational de-novo design of ester hydrolases.” 2013. Web. 17 Jun 2019.

Vancouver:

Richter F. Computational de-novo design of ester hydrolases. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/21829.

Council of Science Editors:

Richter F. Computational de-novo design of ester hydrolases. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/21829


University of Washington

9. Edwards, Thomas Howard. New Statistical Inference Methods for DEER Spectroscopy on Proteins.

Degree: PhD, 2018, University of Washington

 Double Electron-Electron Resonance (DEER) spectroscopy is a pulse-EPR experiment that can provide sub-ångström resolution distance measurements of proteins and other biomacro- molecules in the distance… (more)

Subjects/Keywords: Bayesian Statistics; DEER; EPR; MCMC; Protein; Tikhonov Regularization; Biophysics; Physical chemistry; Chemistry

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APA (6th Edition):

Edwards, T. H. (2018). New Statistical Inference Methods for DEER Spectroscopy on Proteins. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/43000

Chicago Manual of Style (16th Edition):

Edwards, Thomas Howard. “New Statistical Inference Methods for DEER Spectroscopy on Proteins.” 2018. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43000.

MLA Handbook (7th Edition):

Edwards, Thomas Howard. “New Statistical Inference Methods for DEER Spectroscopy on Proteins.” 2018. Web. 17 Jun 2019.

Vancouver:

Edwards TH. New Statistical Inference Methods for DEER Spectroscopy on Proteins. [Internet] [Doctoral dissertation]. University of Washington; 2018. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43000.

Council of Science Editors:

Edwards TH. New Statistical Inference Methods for DEER Spectroscopy on Proteins. [Doctoral Dissertation]. University of Washington; 2018. Available from: http://hdl.handle.net/1773/43000


University of Washington

10. Ueda, George Thomas. Computational Design of Symmetric Protein Complexes with Implications for Vaccine and Biotherapeutic Development.

Degree: PhD, 2019, University of Washington

 Using a newly developed computational docking and scoring method combined with Rosetta two-sided interface design, we demonstrated accurate design of self-assembling oligomeric proteins that exhibit… (more)

Subjects/Keywords: Biotherapeutic; Computational; Design; Engineering; Protein; Vaccine; Biochemistry; Bioengineering; Computational chemistry; Biological chemistry

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APA (6th Edition):

Ueda, G. T. (2019). Computational Design of Symmetric Protein Complexes with Implications for Vaccine and Biotherapeutic Development. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/43303

Chicago Manual of Style (16th Edition):

Ueda, George Thomas. “Computational Design of Symmetric Protein Complexes with Implications for Vaccine and Biotherapeutic Development.” 2019. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43303.

MLA Handbook (7th Edition):

Ueda, George Thomas. “Computational Design of Symmetric Protein Complexes with Implications for Vaccine and Biotherapeutic Development.” 2019. Web. 17 Jun 2019.

Vancouver:

Ueda GT. Computational Design of Symmetric Protein Complexes with Implications for Vaccine and Biotherapeutic Development. [Internet] [Doctoral dissertation]. University of Washington; 2019. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43303.

Council of Science Editors:

Ueda GT. Computational Design of Symmetric Protein Complexes with Implications for Vaccine and Biotherapeutic Development. [Doctoral Dissertation]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/43303


University of Washington

11. Prakash, Arushi. Understanding Self-Assembly in Solution and at Interfaces Using All-Atom Molecular Dynamics Simulations and Enhanced Sampling Methods.

Degree: PhD, 2019, University of Washington

 Proteins and biopolymers self-assemble to form nanostructures in solution or at interfaces. Notable examples include, the formation of plaque during Alzheimer’s disease, and the formation… (more)

Subjects/Keywords: metadynamics; molecular simulations; protein; Computational chemistry; Chemical engineering

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APA (6th Edition):

Prakash, A. (2019). Understanding Self-Assembly in Solution and at Interfaces Using All-Atom Molecular Dynamics Simulations and Enhanced Sampling Methods. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/43324

Chicago Manual of Style (16th Edition):

Prakash, Arushi. “Understanding Self-Assembly in Solution and at Interfaces Using All-Atom Molecular Dynamics Simulations and Enhanced Sampling Methods.” 2019. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43324.

MLA Handbook (7th Edition):

Prakash, Arushi. “Understanding Self-Assembly in Solution and at Interfaces Using All-Atom Molecular Dynamics Simulations and Enhanced Sampling Methods.” 2019. Web. 17 Jun 2019.

Vancouver:

Prakash A. Understanding Self-Assembly in Solution and at Interfaces Using All-Atom Molecular Dynamics Simulations and Enhanced Sampling Methods. [Internet] [Doctoral dissertation]. University of Washington; 2019. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43324.

Council of Science Editors:

Prakash A. Understanding Self-Assembly in Solution and at Interfaces Using All-Atom Molecular Dynamics Simulations and Enhanced Sampling Methods. [Doctoral Dissertation]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/43324


University of Washington

12. Koepnick, Brian. Protein design by citizen scientists.

Degree: PhD, 2019, University of Washington

 Proteins are a class of molecule best known for their tendency to fold into well-defined 3-dimensional structures. The structure of a protein is determined by… (more)

Subjects/Keywords: citizen science; crowdsource; Foldit; protein design; Bioengineering; Biological chemistry

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APA (6th Edition):

Koepnick, B. (2019). Protein design by citizen scientists. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/43642

Chicago Manual of Style (16th Edition):

Koepnick, Brian. “Protein design by citizen scientists.” 2019. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43642.

MLA Handbook (7th Edition):

Koepnick, Brian. “Protein design by citizen scientists.” 2019. Web. 17 Jun 2019.

Vancouver:

Koepnick B. Protein design by citizen scientists. [Internet] [Doctoral dissertation]. University of Washington; 2019. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43642.

Council of Science Editors:

Koepnick B. Protein design by citizen scientists. [Doctoral Dissertation]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/43642

13. Castellanos, Javier Ignacio. Iterative Multistate Negative Design of protein folds.

Degree: PhD, 2014, University of Washington

Subjects/Keywords: Protein Design; Biochemistry; biological chemistry

…helices[5]. Bryson and DeGrado designed a novel globular protein by redesigning a… …protein backbones.! ! The Mayo group developed an alternative strategy for protein design based… …technique Dahiyat and Mayo designed a completely new sequence for a ββα protein based on the zinc… …protein since its sequence contained no information from the natural evolution of the fold… …One of the landmarks of the protein design field was the design of Top7, the first… 

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APA (6th Edition):

Castellanos, J. I. (2014). Iterative Multistate Negative Design of protein folds. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/25971

Chicago Manual of Style (16th Edition):

Castellanos, Javier Ignacio. “Iterative Multistate Negative Design of protein folds.” 2014. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/25971.

MLA Handbook (7th Edition):

Castellanos, Javier Ignacio. “Iterative Multistate Negative Design of protein folds.” 2014. Web. 17 Jun 2019.

Vancouver:

Castellanos JI. Iterative Multistate Negative Design of protein folds. [Internet] [Doctoral dissertation]. University of Washington; 2014. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/25971.

Council of Science Editors:

Castellanos JI. Iterative Multistate Negative Design of protein folds. [Doctoral Dissertation]. University of Washington; 2014. Available from: http://hdl.handle.net/1773/25971


University of Washington

14. Pruneda, Jonathan Nicholas. Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway.

Degree: PhD, 2013, University of Washington

 Thirty years of research have implicated ubiquitin (Ub) signaling in nearly every aspect of eukaryotic cell biology. What appears to be a simple signaling molecule… (more)

Subjects/Keywords: E2 conjugating enzyme; E3 ligase; effector protein; NMR; SAXS; Ubiquitin; Biochemistry; biological chemistry

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APA (6th Edition):

Pruneda, J. N. (2013). Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/22429

Chicago Manual of Style (16th Edition):

Pruneda, Jonathan Nicholas. “Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/22429.

MLA Handbook (7th Edition):

Pruneda, Jonathan Nicholas. “Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway.” 2013. Web. 17 Jun 2019.

Vancouver:

Pruneda JN. Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/22429.

Council of Science Editors:

Pruneda JN. Functional Interactions of E2~Ubiquitin Conjugates in and outside the Ubiquitination Pathway. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/22429


University of Washington

15. Kellogg, Elizabeth Hua-Mei. Assessing and Improving Computational Models of Protein Thermodynamics and Kinetics.

Degree: PhD, 2013, University of Washington

 The purpose of this thesis is to rigorously assess and improve computational models of protein thermodynamics and kinetics. The first part consists of computational ddG… (more)

Subjects/Keywords: ddG prediction; markov state model; protein structure; Rosetta; Biochemistry; Biophysics; biological chemistry

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APA (6th Edition):

Kellogg, E. H. (2013). Assessing and Improving Computational Models of Protein Thermodynamics and Kinetics. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/22430

Chicago Manual of Style (16th Edition):

Kellogg, Elizabeth Hua-Mei. “Assessing and Improving Computational Models of Protein Thermodynamics and Kinetics.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/22430.

MLA Handbook (7th Edition):

Kellogg, Elizabeth Hua-Mei. “Assessing and Improving Computational Models of Protein Thermodynamics and Kinetics.” 2013. Web. 17 Jun 2019.

Vancouver:

Kellogg EH. Assessing and Improving Computational Models of Protein Thermodynamics and Kinetics. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/22430.

Council of Science Editors:

Kellogg EH. Assessing and Improving Computational Models of Protein Thermodynamics and Kinetics. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/22430


University of Washington

16. Basanta, Benjamin. Beyond single-protein de novo design: A generative algorithm for the NTF2-like superfamily.

Degree: PhD, 2019, University of Washington

 Natural proteins evolved over billions of years to regulate cellular growth, ward off infection and capture and store solar energy. Proteins thus serve as the… (more)

Subjects/Keywords: Computational Biology; generative algorithm; generative design; High-throughput screening; Protein design; Biochemistry; Biological chemistry

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APA (6th Edition):

Basanta, B. (2019). Beyond single-protein de novo design: A generative algorithm for the NTF2-like superfamily. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/43640

Chicago Manual of Style (16th Edition):

Basanta, Benjamin. “Beyond single-protein de novo design: A generative algorithm for the NTF2-like superfamily.” 2019. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43640.

MLA Handbook (7th Edition):

Basanta, Benjamin. “Beyond single-protein de novo design: A generative algorithm for the NTF2-like superfamily.” 2019. Web. 17 Jun 2019.

Vancouver:

Basanta B. Beyond single-protein de novo design: A generative algorithm for the NTF2-like superfamily. [Internet] [Doctoral dissertation]. University of Washington; 2019. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43640.

Council of Science Editors:

Basanta B. Beyond single-protein de novo design: A generative algorithm for the NTF2-like superfamily. [Doctoral Dissertation]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/43640


University of Washington

17. Loutey, Dana Elizabeth. Structural and Functional Characterization of Ube2H, a Ubiquitin-Conjugating Enzyme with a C-terminal Extension.

Degree: 2019, University of Washington

 The human proteome contains over forty ubiquitin-conjugating enzymes, each harboring a conserved core domain. Despite their structural similarities, E2s must discriminate between hundreds of E3… (more)

Subjects/Keywords: Protein NMR; Structural biology; Ube2H; Ubiquitin-conjugating enzyme; Ubiquitylation; Biochemistry; Biophysics; Biological chemistry

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APA (6th Edition):

Loutey, D. E. (2019). Structural and Functional Characterization of Ube2H, a Ubiquitin-Conjugating Enzyme with a C-terminal Extension. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/43641

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Loutey, Dana Elizabeth. “Structural and Functional Characterization of Ube2H, a Ubiquitin-Conjugating Enzyme with a C-terminal Extension.” 2019. Thesis, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43641.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Loutey, Dana Elizabeth. “Structural and Functional Characterization of Ube2H, a Ubiquitin-Conjugating Enzyme with a C-terminal Extension.” 2019. Web. 17 Jun 2019.

Vancouver:

Loutey DE. Structural and Functional Characterization of Ube2H, a Ubiquitin-Conjugating Enzyme with a C-terminal Extension. [Internet] [Thesis]. University of Washington; 2019. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43641.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Loutey DE. Structural and Functional Characterization of Ube2H, a Ubiquitin-Conjugating Enzyme with a C-terminal Extension. [Thesis]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/43641

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Washington

18. Perera, Bulathsinhalage Gayani Kanchana. Chemical Proteomic Tools for Studying Protein Kinase Active Sites.

Degree: PhD, 2013, University of Washington

Protein kinases constitute one of the largest protein families in humans. These enzymes catalyze phosphorylation of serine, threonine or tyrosine residues in their protein substrates.… (more)

Subjects/Keywords: Bivalent inhibitors; Clickable kinase inhibitors; DFG-out; Protein Kinase; Proteomic; Type II kinase inhibitors; Chemistry; Biochemistry; Chemistry

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APA (6th Edition):

Perera, B. G. K. (2013). Chemical Proteomic Tools for Studying Protein Kinase Active Sites. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/21742

Chicago Manual of Style (16th Edition):

Perera, Bulathsinhalage Gayani Kanchana. “Chemical Proteomic Tools for Studying Protein Kinase Active Sites.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/21742.

MLA Handbook (7th Edition):

Perera, Bulathsinhalage Gayani Kanchana. “Chemical Proteomic Tools for Studying Protein Kinase Active Sites.” 2013. Web. 17 Jun 2019.

Vancouver:

Perera BGK. Chemical Proteomic Tools for Studying Protein Kinase Active Sites. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/21742.

Council of Science Editors:

Perera BGK. Chemical Proteomic Tools for Studying Protein Kinase Active Sites. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/21742


University of Washington

19. Laszlo, Kenneth Jeffrey. Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States.

Degree: PhD, 2017, University of Washington

 This dissertation explores the utility of cation-to-anion proton transfer reactions (CAPTR) in native mass spectrometry, and investigates the relationship between the charge state (z) and… (more)

Subjects/Keywords: CAPTR; IM-MS; Ion/Ion Reactions; Ion Mobility Spectrometry; Mass Spectrometry; Protein; Analytical chemistry; Biophysics; Chemistry

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APA (6th Edition):

Laszlo, K. J. (2017). Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/39986

Chicago Manual of Style (16th Edition):

Laszlo, Kenneth Jeffrey. “Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States.” 2017. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/39986.

MLA Handbook (7th Edition):

Laszlo, Kenneth Jeffrey. “Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States.” 2017. Web. 17 Jun 2019.

Vancouver:

Laszlo KJ. Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States. [Internet] [Doctoral dissertation]. University of Washington; 2017. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/39986.

Council of Science Editors:

Laszlo KJ. Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States. [Doctoral Dissertation]. University of Washington; 2017. Available from: http://hdl.handle.net/1773/39986

20. Carrico, Christopher T D. Understanding and Manipulating Anti-HIV Antibody Responses via Structural Methods.

Degree: PhD, 2014, University of Washington

 Anti-HIV antibody responses offer one of very few potential routes towards a protective HIV vaccine; structural biochemistry methods such as crystallography and computational modeling can… (more)

Subjects/Keywords: Crystallography; HIV; Protein Design; Protein Structure; Vaccine; Biochemistry; biological chemistry

…gene locus - are recombined to excise all but one of each segment type from the final protein… …N and C termini of the protein sequence, respectively. Additionally, the BCR heavy chain… …same protein might allow successful cell entry prior to effector cell arrival or complement… …protein. Attempts to refine the administration schedules for vaccine candidates to foster… …protein boosting, can both increase antibody titers and steer antibody responses towards desired… 

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APA (6th Edition):

Carrico, C. T. D. (2014). Understanding and Manipulating Anti-HIV Antibody Responses via Structural Methods. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/25107

Chicago Manual of Style (16th Edition):

Carrico, Christopher T D. “Understanding and Manipulating Anti-HIV Antibody Responses via Structural Methods.” 2014. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/25107.

MLA Handbook (7th Edition):

Carrico, Christopher T D. “Understanding and Manipulating Anti-HIV Antibody Responses via Structural Methods.” 2014. Web. 17 Jun 2019.

Vancouver:

Carrico CTD. Understanding and Manipulating Anti-HIV Antibody Responses via Structural Methods. [Internet] [Doctoral dissertation]. University of Washington; 2014. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/25107.

Council of Science Editors:

Carrico CTD. Understanding and Manipulating Anti-HIV Antibody Responses via Structural Methods. [Doctoral Dissertation]. University of Washington; 2014. Available from: http://hdl.handle.net/1773/25107


University of Washington

21. Sanyal, Saurarshi Jyoti. Cooperative Assembly of Terminase and Integration Host Factor at the Packaging Initiation Site of Bacteriophage Lambda.

Degree: PhD, 2013, University of Washington

 Packaging of viral genomes into procapsids by terminase enzymes is conserved in many DNA viruses. Terminases bind to linear concatemers of replicated viral genomes and… (more)

Subjects/Keywords: bacteriophage lambda; cooperativity; integration host factor; protein-DNA interactions; sedimentation equilibrium; sedimentation velocity; Biophysics; Virology; medicinal chemistry

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APA (6th Edition):

Sanyal, S. J. (2013). Cooperative Assembly of Terminase and Integration Host Factor at the Packaging Initiation Site of Bacteriophage Lambda. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/24142

Chicago Manual of Style (16th Edition):

Sanyal, Saurarshi Jyoti. “Cooperative Assembly of Terminase and Integration Host Factor at the Packaging Initiation Site of Bacteriophage Lambda.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/24142.

MLA Handbook (7th Edition):

Sanyal, Saurarshi Jyoti. “Cooperative Assembly of Terminase and Integration Host Factor at the Packaging Initiation Site of Bacteriophage Lambda.” 2013. Web. 17 Jun 2019.

Vancouver:

Sanyal SJ. Cooperative Assembly of Terminase and Integration Host Factor at the Packaging Initiation Site of Bacteriophage Lambda. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/24142.

Council of Science Editors:

Sanyal SJ. Cooperative Assembly of Terminase and Integration Host Factor at the Packaging Initiation Site of Bacteriophage Lambda. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/24142


University of Washington

22. Johansson, Patrik Kjell Ake. Investigations of Protein Fiber Structures and the Interactions at Their Interfaces Using Nonlinear Optical Spectroscopy.

Degree: PhD, 2019, University of Washington

Protein fibers are ubiquitous in nature, either as functional components of cells and tissues, or as hallmarks of severe diseases. Examples include amyloid fibers in… (more)

Subjects/Keywords: Amyloids; Collagen; Nonlinear Optics; Protein Fibers; Second-Harmonic Generation; Sum-Frequency Generation; Biomedical engineering; Physical chemistry; Bioengineering

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APA (6th Edition):

Johansson, P. K. A. (2019). Investigations of Protein Fiber Structures and the Interactions at Their Interfaces Using Nonlinear Optical Spectroscopy. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/43297

Chicago Manual of Style (16th Edition):

Johansson, Patrik Kjell Ake. “Investigations of Protein Fiber Structures and the Interactions at Their Interfaces Using Nonlinear Optical Spectroscopy.” 2019. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/43297.

MLA Handbook (7th Edition):

Johansson, Patrik Kjell Ake. “Investigations of Protein Fiber Structures and the Interactions at Their Interfaces Using Nonlinear Optical Spectroscopy.” 2019. Web. 17 Jun 2019.

Vancouver:

Johansson PKA. Investigations of Protein Fiber Structures and the Interactions at Their Interfaces Using Nonlinear Optical Spectroscopy. [Internet] [Doctoral dissertation]. University of Washington; 2019. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/43297.

Council of Science Editors:

Johansson PKA. Investigations of Protein Fiber Structures and the Interactions at Their Interfaces Using Nonlinear Optical Spectroscopy. [Doctoral Dissertation]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/43297

23. Zhao, Chunsheng. Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms.

Degree: PhD, 2012, University of Washington

 Cytochrome b5 (cyt b5 or holo b5) is known as one of the key components in the microsomal cytochrome P450 (CYP) monooxygenase system that metabolizes… (more)

Subjects/Keywords: allosteric effect; cross-linking; cytochrome b5; cytochrome P450s; mass spectrometry; protein interaction; Pharmaceutical sciences; Biochemistry; Analytical chemistry; Medicinal chemistry

…135 4.2.2 Protein Expression and Purification… …of Medicinal Chemistry and Pharmaceutics, and the UW Proteomics Center. It is their… …sulfur protein and ferredoxin reductase. The Class II family includes microsomal P450s… …bound protein containing FAD and FMN cofactors. Cytochrome b5 (cyt b5) may also… …transfer to an acceptor protein. Further study provided evidence showing that internal electron… 

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APA (6th Edition):

Zhao, C. (2012). Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/20655

Chicago Manual of Style (16th Edition):

Zhao, Chunsheng. “Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms.” 2012. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/20655.

MLA Handbook (7th Edition):

Zhao, Chunsheng. “Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms.” 2012. Web. 17 Jun 2019.

Vancouver:

Zhao C. Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms. [Internet] [Doctoral dissertation]. University of Washington; 2012. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/20655.

Council of Science Editors:

Zhao C. Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms. [Doctoral Dissertation]. University of Washington; 2012. Available from: http://hdl.handle.net/1773/20655

24. King, Chris. Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions.

Degree: PhD, 2014, University of Washington

 Proteins possess huge potential as therapeutic agents for the control and modulation of human physiology. Protein interactions regulate most physiological processes, mediating the connection between… (more)

Subjects/Keywords: biotherapeutics; deimmunization; machine learning; molecular modeling; protein design; Biochemistry; Bioinformatics; Biophysics; biological chemistry

…Basis of Immunogenicity All protein-­‐based drugs have the potential… …T cells by T cell epitopes in the protein drug… …proteins exogenously even when the protein is originally present in… …innate immune activation, and protein aggregation. The… …protein drug is taken up by antigen-­‐presenting cells (APCs)… 

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APA (6th Edition):

King, C. (2014). Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/25382

Chicago Manual of Style (16th Edition):

King, Chris. “Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions.” 2014. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/25382.

MLA Handbook (7th Edition):

King, Chris. “Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions.” 2014. Web. 17 Jun 2019.

Vancouver:

King C. Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions. [Internet] [Doctoral dissertation]. University of Washington; 2014. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/25382.

Council of Science Editors:

King C. Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions. [Doctoral Dissertation]. University of Washington; 2014. Available from: http://hdl.handle.net/1773/25382

25. Keefe, Andrew. Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications.

Degree: PhD, 2013, University of Washington

 Controlling nonspecific protein interactions is important for applications from medical devices to protein therapeutics. The presented work is a compilation of efforts aimed at using… (more)

Subjects/Keywords: biomaterials; combinatorial chemistry; peptides; protein polymer conjugation; surface modification; zwitterions; Chemical engineering; Biomedical engineering; Biochemistry; chemical engineering

…pCB shares similarities in chemistry to polymers found on protein surfaces and cell… …17 Figure 2.4: Protein FITC-BSA imobilization on pCBMA-modified PDMS surfaces… …49 Figure 4.2: Synthesis and formation of carboxybetaine-protein conjugates… …sequence (SS) used for expression of the β-lactamase protein and the genes for three… …for evaluating nonspecific protein adsorption… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Keefe, A. (2013). Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/24170

Chicago Manual of Style (16th Edition):

Keefe, Andrew. “Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications.” 2013. Doctoral Dissertation, University of Washington. Accessed June 17, 2019. http://hdl.handle.net/1773/24170.

MLA Handbook (7th Edition):

Keefe, Andrew. “Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications.” 2013. Web. 17 Jun 2019.

Vancouver:

Keefe A. Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2019 Jun 17]. Available from: http://hdl.handle.net/1773/24170.

Council of Science Editors:

Keefe A. Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/24170

.