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University: University of Michigan

You searched for subject:(Protein Engineering). Showing records 1 – 22 of 22 total matches.

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University of Michigan

1. Ismail, Tania. Role of Biomolecule Cues in Alzheimer’s disease.

Degree: MSin Engineering, Bioengineering, College of Engineering & Computer Science, 2017, University of Michigan

 The master’s thesis study investigates the role of biomolecules in Alzheimer’s disease. Alzheimer’s disease is caused by amyloid plaques and neurofibrillary tangles. The major cause… (more)

Subjects/Keywords: Protein; Alzheimers; Aggregation; Amyloid; Tau; Glycosaminoglycans; Biomedical engineering

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APA (6th Edition):

Ismail, T. (2017). Role of Biomolecule Cues in Alzheimer’s disease. (Masters Thesis). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/140773

Chicago Manual of Style (16th Edition):

Ismail, Tania. “Role of Biomolecule Cues in Alzheimer’s disease.” 2017. Masters Thesis, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/140773.

MLA Handbook (7th Edition):

Ismail, Tania. “Role of Biomolecule Cues in Alzheimer’s disease.” 2017. Web. 08 Jul 2020.

Vancouver:

Ismail T. Role of Biomolecule Cues in Alzheimer’s disease. [Internet] [Masters thesis]. University of Michigan; 2017. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/140773.

Council of Science Editors:

Ismail T. Role of Biomolecule Cues in Alzheimer’s disease. [Masters Thesis]. University of Michigan; 2017. Available from: http://hdl.handle.net/2027.42/140773


University of Michigan

2. Batzli, Kiersten Marie. Insulin-based Nanowire Structures: Production, Characterization and Catalysis Potential.

Degree: PhD, Materials Science and Engineering, 2015, University of Michigan

 Use of proteins as bio-templates for production of nanowires and materials is a burgeoning field of research making use of intrinsic protein characteristics and tendencies… (more)

Subjects/Keywords: platinum nanowires; bionanotechnology; protein-templated nanowire; catalysis; Materials Science and Engineering; Engineering

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APA (6th Edition):

Batzli, K. M. (2015). Insulin-based Nanowire Structures: Production, Characterization and Catalysis Potential. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/111617

Chicago Manual of Style (16th Edition):

Batzli, Kiersten Marie. “Insulin-based Nanowire Structures: Production, Characterization and Catalysis Potential.” 2015. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/111617.

MLA Handbook (7th Edition):

Batzli, Kiersten Marie. “Insulin-based Nanowire Structures: Production, Characterization and Catalysis Potential.” 2015. Web. 08 Jul 2020.

Vancouver:

Batzli KM. Insulin-based Nanowire Structures: Production, Characterization and Catalysis Potential. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/111617.

Council of Science Editors:

Batzli KM. Insulin-based Nanowire Structures: Production, Characterization and Catalysis Potential. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/111617

3. Patel, Janki Jayesh. Single and Dual Growth Factor Delivery from Poly-E-caprolactone Scaffolds for Pre-Fabricated Bone Flap Engineering.

Degree: PhD, Biomedical Engineering, 2015, University of Michigan

 Autografts are utilized to reconstruct large craniofacial bone defects; however, they result in donor site morbidity and defect geometry mismatch. Pre-fabricating a bone flap overcomes… (more)

Subjects/Keywords: Bone Tissue Engineering; Polycaprolactone; Bone Morphogenetic Protein-2; Vascular Endothelial Growth Factor; Erythropoietin; Biomedical Engineering; Engineering; Science

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APA (6th Edition):

Patel, J. J. (2015). Single and Dual Growth Factor Delivery from Poly-E-caprolactone Scaffolds for Pre-Fabricated Bone Flap Engineering. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/111451

Chicago Manual of Style (16th Edition):

Patel, Janki Jayesh. “Single and Dual Growth Factor Delivery from Poly-E-caprolactone Scaffolds for Pre-Fabricated Bone Flap Engineering.” 2015. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/111451.

MLA Handbook (7th Edition):

Patel, Janki Jayesh. “Single and Dual Growth Factor Delivery from Poly-E-caprolactone Scaffolds for Pre-Fabricated Bone Flap Engineering.” 2015. Web. 08 Jul 2020.

Vancouver:

Patel JJ. Single and Dual Growth Factor Delivery from Poly-E-caprolactone Scaffolds for Pre-Fabricated Bone Flap Engineering. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/111451.

Council of Science Editors:

Patel JJ. Single and Dual Growth Factor Delivery from Poly-E-caprolactone Scaffolds for Pre-Fabricated Bone Flap Engineering. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/111451


University of Michigan

4. Hoff, Jeremy Damon. Nanoscale Protein Patterning via Nanoimprint Lithography and Ultrafast Laser Irradiation.

Degree: PhD, Biomedical Engineering, 2009, University of Michigan

 The diverse biological roles of proteins include catalysis, force generation, mechanical support, signaling and sensing. Beyond their central importance to biology, proteins are of interest… (more)

Subjects/Keywords: Protein Patterning; Nanoimprint Lithography; Laser Ablation; Biomedical Engineering; Engineering

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APA (6th Edition):

Hoff, J. D. (2009). Nanoscale Protein Patterning via Nanoimprint Lithography and Ultrafast Laser Irradiation. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/62197

Chicago Manual of Style (16th Edition):

Hoff, Jeremy Damon. “Nanoscale Protein Patterning via Nanoimprint Lithography and Ultrafast Laser Irradiation.” 2009. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/62197.

MLA Handbook (7th Edition):

Hoff, Jeremy Damon. “Nanoscale Protein Patterning via Nanoimprint Lithography and Ultrafast Laser Irradiation.” 2009. Web. 08 Jul 2020.

Vancouver:

Hoff JD. Nanoscale Protein Patterning via Nanoimprint Lithography and Ultrafast Laser Irradiation. [Internet] [Doctoral dissertation]. University of Michigan; 2009. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/62197.

Council of Science Editors:

Hoff JD. Nanoscale Protein Patterning via Nanoimprint Lithography and Ultrafast Laser Irradiation. [Doctoral Dissertation]. University of Michigan; 2009. Available from: http://hdl.handle.net/2027.42/62197


University of Michigan

5. Yusko, Erik Christian. Nanopores with Fluid Walls for Characterizing Proteins and Peptides.

Degree: PhD, Biomedical Engineering, 2012, University of Michigan

 Nanopore-based, resistive-pulse sensing is a simple single-molecule technique, is label free, and employs basic electronic recording equipment. This technique shows promise for rapid, multi-parameter characterization… (more)

Subjects/Keywords: Resistive Pulse; Coulter Couting; Nanopore; Protein Characterization; Protein Size Charge Shape Rotational Diffusion Coefficient and Dipole Moment; Biomedical Engineering; Chemistry; Physics; Science (General); Health Sciences; Science

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APA (6th Edition):

Yusko, E. C. (2012). Nanopores with Fluid Walls for Characterizing Proteins and Peptides. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/96049

Chicago Manual of Style (16th Edition):

Yusko, Erik Christian. “Nanopores with Fluid Walls for Characterizing Proteins and Peptides.” 2012. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/96049.

MLA Handbook (7th Edition):

Yusko, Erik Christian. “Nanopores with Fluid Walls for Characterizing Proteins and Peptides.” 2012. Web. 08 Jul 2020.

Vancouver:

Yusko EC. Nanopores with Fluid Walls for Characterizing Proteins and Peptides. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/96049.

Council of Science Editors:

Yusko EC. Nanopores with Fluid Walls for Characterizing Proteins and Peptides. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/96049

6. Cristie-David, Ajitha. Symmetry-Based Design of Protein Nano-Cages.

Degree: PhD, Chemistry, 2019, University of Michigan

 The self-assembly of protein subunits into large-scale oligomeric structures is a powerful and ubiquitous feature of biology, with viral capsids providing an excellent example. These… (more)

Subjects/Keywords: Protein Nano-cages; Protein design and engineering; Coiled-coil mediated protein assemblies; Biological Chemistry; Science

protein re-engineering. Many viral capsids are dynamic structures and some capsids can undergo… …new field of protein design and engineering, which allowed design of both closed-cage like… …86 Chapter 4: Designing a Coiled Coil-Mediated Assembly of an Icosahedral Protein Cage… …91 4.2.2 Protein Expression and Purification… …125 vii Chapter 5: Designing a Metal-dependent Protein Cage… 

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APA (6th Edition):

Cristie-David, A. (2019). Symmetry-Based Design of Protein Nano-Cages. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/149900

Chicago Manual of Style (16th Edition):

Cristie-David, Ajitha. “Symmetry-Based Design of Protein Nano-Cages.” 2019. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/149900.

MLA Handbook (7th Edition):

Cristie-David, Ajitha. “Symmetry-Based Design of Protein Nano-Cages.” 2019. Web. 08 Jul 2020.

Vancouver:

Cristie-David A. Symmetry-Based Design of Protein Nano-Cages. [Internet] [Doctoral dissertation]. University of Michigan; 2019. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/149900.

Council of Science Editors:

Cristie-David A. Symmetry-Based Design of Protein Nano-Cages. [Doctoral Dissertation]. University of Michigan; 2019. Available from: http://hdl.handle.net/2027.42/149900

7. Chen, Zhilin. Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation.

Degree: PhD, Pharmaceutical Sciences, 2019, University of Michigan

 Epitope density appears to be a critical factor in pathogens that can elicit effective immune responses. All the viruses that have efficacious FDA-approved target vaccines… (more)

Subjects/Keywords: Antigen density; HIV Gag protein self-assembly; Liposome surface protein conjugation characterization; Engineered nanoparticles with controlled densities of antigens; Biomedical Engineering; Biological Chemistry; Microbiology and Immunology; Pharmacy and Pharmacology; Engineering; Health Sciences; Science

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APA (6th Edition):

Chen, Z. (2019). Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/149967

Chicago Manual of Style (16th Edition):

Chen, Zhilin. “Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation.” 2019. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/149967.

MLA Handbook (7th Edition):

Chen, Zhilin. “Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation.” 2019. Web. 08 Jul 2020.

Vancouver:

Chen Z. Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation. [Internet] [Doctoral dissertation]. University of Michigan; 2019. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/149967.

Council of Science Editors:

Chen Z. Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation. [Doctoral Dissertation]. University of Michigan; 2019. Available from: http://hdl.handle.net/2027.42/149967

8. Bruhn, Brandon Robert. Nanopore-Based Methods for Characterizing Single Proteins.

Degree: PhD, Biomedical Engineering, 2015, University of Michigan

 Proteins represent the most diverse class of biomolecules in both structure and function and are involved in nearly every physiological process; their quantification, identification, and… (more)

Subjects/Keywords: Single protein biophysics; Single molecule sensing; Biotechnology; Biomedical Engineering; Engineering

…3.2.2 Rotation of a single protein modulates the ionic current through a nanopore… …63 3.2.3. Multiparameter-characterization of individual proteins improves protein… …potentials yield consistent estimates of protein shape ............... 96 Forces acting on proteins… …anchoring on the measurement of protein properties .. 106 3-App.S5 Simulating translocation events… …Determining the dipole moment of a protein from fitting intra-event ΔI values… 

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APA (6th Edition):

Bruhn, B. R. (2015). Nanopore-Based Methods for Characterizing Single Proteins. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/111522

Chicago Manual of Style (16th Edition):

Bruhn, Brandon Robert. “Nanopore-Based Methods for Characterizing Single Proteins.” 2015. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/111522.

MLA Handbook (7th Edition):

Bruhn, Brandon Robert. “Nanopore-Based Methods for Characterizing Single Proteins.” 2015. Web. 08 Jul 2020.

Vancouver:

Bruhn BR. Nanopore-Based Methods for Characterizing Single Proteins. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/111522.

Council of Science Editors:

Bruhn BR. Nanopore-Based Methods for Characterizing Single Proteins. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/111522


University of Michigan

9. Shi, Weixian. Study of Interactions of DNA with RECA and Other Proteins.

Degree: PhD, Chemical Engineering, 2008, University of Michigan

 This thesis describes different methods of stretching DNA using flow fields and investigates the aggregation behavior of RecA-DNA filaments in addition to the preliminary work… (more)

Subjects/Keywords: RecA; Atomic Force Microscopy; Supercoiling; Protein and DNA Interactions; Engineering; Science

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APA (6th Edition):

Shi, W. (2008). Study of Interactions of DNA with RECA and Other Proteins. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/58526

Chicago Manual of Style (16th Edition):

Shi, Weixian. “Study of Interactions of DNA with RECA and Other Proteins.” 2008. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/58526.

MLA Handbook (7th Edition):

Shi, Weixian. “Study of Interactions of DNA with RECA and Other Proteins.” 2008. Web. 08 Jul 2020.

Vancouver:

Shi W. Study of Interactions of DNA with RECA and Other Proteins. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/58526.

Council of Science Editors:

Shi W. Study of Interactions of DNA with RECA and Other Proteins. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/58526

10. Nam, Woochul. Dynamics of Intracellular Nano-Transport by Kinesins.

Degree: PhD, Mechanical Engineering, 2015, University of Michigan

 Transport in neurons is realized by motor proteins (kinesins) which walk along intracellular tracks. Healthy mechanical transport is necessary for neurons to maintain their normal… (more)

Subjects/Keywords: Kinesin; Intracellular transport; Tau protein; Alzheimer's disease; Biomedical Engineering; Mechanical Engineering; Engineering; Science

…the rate constant k1b is minimum (k1b = k1b,0 ) when the protein is in equilibrium… 

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APA (6th Edition):

Nam, W. (2015). Dynamics of Intracellular Nano-Transport by Kinesins. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/111618

Chicago Manual of Style (16th Edition):

Nam, Woochul. “Dynamics of Intracellular Nano-Transport by Kinesins.” 2015. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/111618.

MLA Handbook (7th Edition):

Nam, Woochul. “Dynamics of Intracellular Nano-Transport by Kinesins.” 2015. Web. 08 Jul 2020.

Vancouver:

Nam W. Dynamics of Intracellular Nano-Transport by Kinesins. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/111618.

Council of Science Editors:

Nam W. Dynamics of Intracellular Nano-Transport by Kinesins. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/111618

11. Mitsak, Anna Guyer. Bone Tissue Engineering Using High Permeability Poly-e-caprolactone Scaffolds Conjugated with Bone Morphogenetic Protein-2.

Degree: PhD, Biomedical Engineering, 2012, University of Michigan

 Bone is the second most commonly transplanted tissue in the United States. Limitations of current bone defect treatment options include morbidity at the autograft harvest… (more)

Subjects/Keywords: Scaffold Tissue Engineering; Bone Morphogenetic Protein-2; Polycaprolactone; Biomedical Engineering; Engineering

…2 1.3 Scaffold Tissue Engineering… …31 Chapter 3 Scaffold Tissue Engineering: Developing a Complete System for Repairing and… …glycerol sebacate) for Soft Tissue Engineering… …scaffold permeability, conjugated bone morphogenetic protein-2 (BMP-2) and… …designed architectures. A polymer for bone tissue engineering must be biocompatible… 

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APA (6th Edition):

Mitsak, A. G. (2012). Bone Tissue Engineering Using High Permeability Poly-e-caprolactone Scaffolds Conjugated with Bone Morphogenetic Protein-2. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/95994

Chicago Manual of Style (16th Edition):

Mitsak, Anna Guyer. “Bone Tissue Engineering Using High Permeability Poly-e-caprolactone Scaffolds Conjugated with Bone Morphogenetic Protein-2.” 2012. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/95994.

MLA Handbook (7th Edition):

Mitsak, Anna Guyer. “Bone Tissue Engineering Using High Permeability Poly-e-caprolactone Scaffolds Conjugated with Bone Morphogenetic Protein-2.” 2012. Web. 08 Jul 2020.

Vancouver:

Mitsak AG. Bone Tissue Engineering Using High Permeability Poly-e-caprolactone Scaffolds Conjugated with Bone Morphogenetic Protein-2. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/95994.

Council of Science Editors:

Mitsak AG. Bone Tissue Engineering Using High Permeability Poly-e-caprolactone Scaffolds Conjugated with Bone Morphogenetic Protein-2. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/95994

12. Park, Jungkap. Rotamer-specific Statistical Potentials for Protein Structure Modeling.

Degree: PhD, Mechanical Engineering, 2013, University of Michigan

 Knowledge-based (or statistical) potentials are widely used as essential tools in protein structure modeling and quality assessment. They are derived from experimentally determined protein structures… (more)

Subjects/Keywords: Protein Structure Prediction; Statistical Potential Energy Function; Rotamer-specific Multibody Potential; Mechanical Engineering; Engineering

Protein Data Bank (PDB) and Protein Information Resources (PIR) are a… …proteins. Understanding of protein energetics allows us to approximate the interaction energy in… …3 Figure 2-1. Computational protein design aims to find an optimal combination of amino… …acid types and their rotameric states for a desired protein backbone structure with minimum… …successful protein structure modeling because they are used for scoring structures and potentially… 

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APA (6th Edition):

Park, J. (2013). Rotamer-specific Statistical Potentials for Protein Structure Modeling. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/102342

Chicago Manual of Style (16th Edition):

Park, Jungkap. “Rotamer-specific Statistical Potentials for Protein Structure Modeling.” 2013. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/102342.

MLA Handbook (7th Edition):

Park, Jungkap. “Rotamer-specific Statistical Potentials for Protein Structure Modeling.” 2013. Web. 08 Jul 2020.

Vancouver:

Park J. Rotamer-specific Statistical Potentials for Protein Structure Modeling. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/102342.

Council of Science Editors:

Park J. Rotamer-specific Statistical Potentials for Protein Structure Modeling. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/102342

13. Song, James. A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides.

Degree: PhD, Chemical Biology, 2018, University of Michigan

 Cap-dependent protein translation (CdT) is dysregulated in many types of cancer and leads to overexpression of oncogenes promoting angiogenesis, evasion of apoptosis, and cell proliferation.… (more)

Subjects/Keywords: drug discovery high throughput screening; protein-protein interaction assay development; chemical biology; cap-dependent translation initiation; hydrocarbon stapled peptides targeting eIF4E interactions; protein-protein interactions; Astronomy; Atmospheric, Oceanic and Space Sciences; Biological Chemistry; Chemical Engineering; Chemistry; Science

…30 Figure 7. The mechanism of Halotag Protein labeling. A) Amine–reactive crosslinker… …NHS ester forms amide with surfaced exposed lysines on the protein, B) chloro–alkane… …35 Figure 10. 4E-BP1, eIF4E and eIF4G Labeling. A) PPI cat–ELCCA protein labeling… …Proof–of–concept data. X refers to protein. C) Kd,app measurement. All experiments were… …108 xv ABSTRACT Cap-dependent protein translation (CdT) is dysregulated in… 

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APA (6th Edition):

Song, J. (2018). A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/145870

Chicago Manual of Style (16th Edition):

Song, James. “A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides.” 2018. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/145870.

MLA Handbook (7th Edition):

Song, James. “A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides.” 2018. Web. 08 Jul 2020.

Vancouver:

Song J. A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides. [Internet] [Doctoral dissertation]. University of Michigan; 2018. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/145870.

Council of Science Editors:

Song J. A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides. [Doctoral Dissertation]. University of Michigan; 2018. Available from: http://hdl.handle.net/2027.42/145870

14. Sobczynski, Daniel J. The Impact of the Plasma Protein Corona on the Adhesion Efficiency of Drug Carriers to the Blood Vessel Wall.

Degree: PhD, Chemical Engineering, 2016, University of Michigan

 Upon injection of vascular-targeted drug carriers into the bloodstream, plasma proteins rapidly coat the carrier surface, forming a plasma protein corona. This corona is dependent… (more)

Subjects/Keywords: Plasma protein corona; Vascular-targeted drug delivery; Blood flow adhesion efficiency; Biomedical Engineering; Chemical Engineering; Engineering; Science

…35 CHAPTER 3: PLASMA PROTEIN CORONA MODULATES THE VASCULAR WALL INTERACTION OF DRUG… …49 3.2.4 Evaluation of potential plasma protein effects on other VTC material types .. 51… …3.2.5 Characterization of protein adsorption on PLGA versus PS spheres ............... 56 3.3… …85 5.2.3 Characterization of zeta potential and protein corona profile on VTCs… …104 6.2.4 Evaluation of differences in VTC protein corona relative to blood characteristic… 

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APA (6th Edition):

Sobczynski, D. J. (2016). The Impact of the Plasma Protein Corona on the Adhesion Efficiency of Drug Carriers to the Blood Vessel Wall. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/133204

Chicago Manual of Style (16th Edition):

Sobczynski, Daniel J. “The Impact of the Plasma Protein Corona on the Adhesion Efficiency of Drug Carriers to the Blood Vessel Wall.” 2016. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/133204.

MLA Handbook (7th Edition):

Sobczynski, Daniel J. “The Impact of the Plasma Protein Corona on the Adhesion Efficiency of Drug Carriers to the Blood Vessel Wall.” 2016. Web. 08 Jul 2020.

Vancouver:

Sobczynski DJ. The Impact of the Plasma Protein Corona on the Adhesion Efficiency of Drug Carriers to the Blood Vessel Wall. [Internet] [Doctoral dissertation]. University of Michigan; 2016. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/133204.

Council of Science Editors:

Sobczynski DJ. The Impact of the Plasma Protein Corona on the Adhesion Efficiency of Drug Carriers to the Blood Vessel Wall. [Doctoral Dissertation]. University of Michigan; 2016. Available from: http://hdl.handle.net/2027.42/133204

15. Mellacheruvu, Dattatreya. A Computational and Informatics Framework for the Analysis of Affinity Purification Mass Spectrometry Data and Reconstruction of Protein Interaction Networks.

Degree: PhD, Bioinformatics, 2015, University of Michigan

 Affinity purification coupled with mass spectrometry (AP-MS) is a high-throughput approach to detect protein interactions, where a protein complex is affinity-purified using an antibody targeted… (more)

Subjects/Keywords: Bioinformatics; Proteomics; Protein interaction networks; Affinity purification mass spectrometry; Biomedical Engineering; Health Sciences

…Most Frequently detected protein families across the CRAPome (V 1.0)… …85 ix CHAPTER 1 Introduction Significance of protein interactions Proteins play a… …other proteins and bio-molecules (DNA, RNA, small molecules). Protein complexes, i.e… …intricately arranged protein sub-units. Such protein complexes are typically held together by… …stable’ protein interactions. On the other hand, several weak and transient interactions are… 

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APA (6th Edition):

Mellacheruvu, D. (2015). A Computational and Informatics Framework for the Analysis of Affinity Purification Mass Spectrometry Data and Reconstruction of Protein Interaction Networks. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/111349

Chicago Manual of Style (16th Edition):

Mellacheruvu, Dattatreya. “A Computational and Informatics Framework for the Analysis of Affinity Purification Mass Spectrometry Data and Reconstruction of Protein Interaction Networks.” 2015. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/111349.

MLA Handbook (7th Edition):

Mellacheruvu, Dattatreya. “A Computational and Informatics Framework for the Analysis of Affinity Purification Mass Spectrometry Data and Reconstruction of Protein Interaction Networks.” 2015. Web. 08 Jul 2020.

Vancouver:

Mellacheruvu D. A Computational and Informatics Framework for the Analysis of Affinity Purification Mass Spectrometry Data and Reconstruction of Protein Interaction Networks. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/111349.

Council of Science Editors:

Mellacheruvu D. A Computational and Informatics Framework for the Analysis of Affinity Purification Mass Spectrometry Data and Reconstruction of Protein Interaction Networks. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/111349

16. Dugan, Amanda Elizabeth. Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids.

Degree: PhD, Chemical Biology, 2013, University of Michigan

 Transient and moderate affinity protein-protein interactions (PPIs) play a critical role in the regulation of essential cellular processes including protein folding, ubiquitylation, and transcription. A… (more)

Subjects/Keywords: Unnatural Amino Acids, Protein Engineering, Transcriptional Activation, Covalent Chemical Capture; Biological Chemistry; Chemistry; Science

…6 Figure 1-4 At the core of transcriptional PPI networks are multi-protein complexes… …8 Figure 1-5 Activator-masking protein interactions are often defined by high affinity and… …LexA+VP16 and the Mediator protein, Med15… …97 x Abstract COVALENT CHEMICAL CAPTURE OF TRANSCRIPTION PROTEIN-PROTEIN INTERACTIONS… …Mapp Critical to the regulation of nearly every cellular process are protein-protein… 

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APA (6th Edition):

Dugan, A. E. (2013). Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/102310

Chicago Manual of Style (16th Edition):

Dugan, Amanda Elizabeth. “Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids.” 2013. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/102310.

MLA Handbook (7th Edition):

Dugan, Amanda Elizabeth. “Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids.” 2013. Web. 08 Jul 2020.

Vancouver:

Dugan AE. Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/102310.

Council of Science Editors:

Dugan AE. Covalent Chemical Capture of Transcriptional Protein-Protein Interactions Using Genetically Incorporated Photo-crosslinking Amino Acids. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/102310


University of Michigan

17. Sommer, Gregory Jon. Electrokinetic Gradient-Based Focusing Mechanisms for Rapid, On-Chip Concentration and Separation of Proteins.

Degree: PhD, Mechanical Engineering, 2008, University of Michigan

 Biochemical assays have seen a trend toward miniaturization as researchers strive to develop faster, more sensitive, and less expensive assays. Sample enrichment is often required… (more)

Subjects/Keywords: Microfluidics; Temperature Gradient Focusing; Isoelectric Focusing; Pore Limit Electrophoresis; Protein Concentration and Separation; Engineering; Science

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APA (6th Edition):

Sommer, G. J. (2008). Electrokinetic Gradient-Based Focusing Mechanisms for Rapid, On-Chip Concentration and Separation of Proteins. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/58414

Chicago Manual of Style (16th Edition):

Sommer, Gregory Jon. “Electrokinetic Gradient-Based Focusing Mechanisms for Rapid, On-Chip Concentration and Separation of Proteins.” 2008. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/58414.

MLA Handbook (7th Edition):

Sommer, Gregory Jon. “Electrokinetic Gradient-Based Focusing Mechanisms for Rapid, On-Chip Concentration and Separation of Proteins.” 2008. Web. 08 Jul 2020.

Vancouver:

Sommer GJ. Electrokinetic Gradient-Based Focusing Mechanisms for Rapid, On-Chip Concentration and Separation of Proteins. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/58414.

Council of Science Editors:

Sommer GJ. Electrokinetic Gradient-Based Focusing Mechanisms for Rapid, On-Chip Concentration and Separation of Proteins. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/58414

18. Lin, Zhao. The Function and Regulation of LIM Domain Mineralization Protein (LMP) in Periodontal Ligament Progenitor Cells.

Degree: PhD, Oral Health Sciences, 2010, University of Michigan

 New methodologies to target and deliver osteogenic factors offer significant potential for craniofacial tissue engineering. LIM domain mineralization protein (LMP) appears to be such a… (more)

Subjects/Keywords: LIM Domain Mineralization Protein; Periodontal Ligament Cell; Tissue Engineering; Gene Regulation; Dentistry; Health Sciences

…significant potential for craniofacial tissue engineering. LIM domain mineralization protein (… …127 viii LIST OF FIGURES Figure 1-1 Paradigm of periodontal tissue engineering… …92 Figure 5-1 LMP1 gene and protein expression is regulated by TGF-β1 in PDL cells...108… …regeneration …21 Table 1-2 Viral and nonviral gene therapy vectors used in tissue engineering… …22 Table 1-3 Scaffold protein LMP1 interacts with several intracellular proteins 23… 

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APA (6th Edition):

Lin, Z. (2010). The Function and Regulation of LIM Domain Mineralization Protein (LMP) in Periodontal Ligament Progenitor Cells. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/77924

Chicago Manual of Style (16th Edition):

Lin, Zhao. “The Function and Regulation of LIM Domain Mineralization Protein (LMP) in Periodontal Ligament Progenitor Cells.” 2010. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/77924.

MLA Handbook (7th Edition):

Lin, Zhao. “The Function and Regulation of LIM Domain Mineralization Protein (LMP) in Periodontal Ligament Progenitor Cells.” 2010. Web. 08 Jul 2020.

Vancouver:

Lin Z. The Function and Regulation of LIM Domain Mineralization Protein (LMP) in Periodontal Ligament Progenitor Cells. [Internet] [Doctoral dissertation]. University of Michigan; 2010. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/77924.

Council of Science Editors:

Lin Z. The Function and Regulation of LIM Domain Mineralization Protein (LMP) in Periodontal Ligament Progenitor Cells. [Doctoral Dissertation]. University of Michigan; 2010. Available from: http://hdl.handle.net/2027.42/77924

19. Ding, Xinqiang. Methodological Advances for Drug Discovery and Protein Engineering.

Degree: PhD, Bioinformatics, 2018, University of Michigan

 Designing and engineering molecules that have specified properties not only test our understanding of nature but also play an important role in improving both human… (more)

Subjects/Keywords: drug discovery; protein engineering; protein-ligand docking; free energy calculation; machine learning; statistics; Biomedical Engineering; Chemical Engineering; Pharmacy and Pharmacology; Chemistry; Ecology and Evolutionary Biology; Physics; Statistics and Numeric Data; Engineering; Health Sciences; Science

…and protein engineering, which develops useful proteins for medical purposes or catalyzing… …industrial chemical reactions. Drug discovery and protein engineering are both timeconsuming and… …methodologies for drug discovery and protein engineering that exploit evolving accelerated computing… …protein engineering, I investigated the development and application of variational auto-encoder… …protein engineering efforts. viii CHAPTER 1 Introduction Designing and engineering molecules… 

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APA (6th Edition):

Ding, X. (2018). Methodological Advances for Drug Discovery and Protein Engineering. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/147634

Chicago Manual of Style (16th Edition):

Ding, Xinqiang. “Methodological Advances for Drug Discovery and Protein Engineering.” 2018. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/147634.

MLA Handbook (7th Edition):

Ding, Xinqiang. “Methodological Advances for Drug Discovery and Protein Engineering.” 2018. Web. 08 Jul 2020.

Vancouver:

Ding X. Methodological Advances for Drug Discovery and Protein Engineering. [Internet] [Doctoral dissertation]. University of Michigan; 2018. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/147634.

Council of Science Editors:

Ding X. Methodological Advances for Drug Discovery and Protein Engineering. [Doctoral Dissertation]. University of Michigan; 2018. Available from: http://hdl.handle.net/2027.42/147634

20. Horger, Kim Soon. Formation of Physiologically Relevant Liposomes.

Degree: PhD, Chemical Engineering, 2013, University of Michigan

 In the first part of this work, we addressed the challenge of producing giant unilamellar vesicles (GUV) in solutions of physiologic ionic strength. Methods of… (more)

Subjects/Keywords: Giant Unilamellar Vesicle; Giant Proteoliposome; P-glycoprotein Transporter Protein; Transport and Passive Diffusion Analysis; Multidrug Resistance, MDR; Physiologic Ionic Strength; Biomedical Engineering; Chemical Engineering; Engineering

…3.2.2 Assessment of protein function using a transport assay ............................ 66… …81 3.4.6 Assessment of protein activity after reconstitution into giant liposomes .... 82… …Active transport of Rho123 requires the presence of functional transporter protein and ATP… …experiments revealed the presence of a chloride ion channel protein that co-purified from the host… …the protein is embedded in the hydrophobic region of the bilayer.(1) Integral… 

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APA (6th Edition):

Horger, K. S. (2013). Formation of Physiologically Relevant Liposomes. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/99769

Chicago Manual of Style (16th Edition):

Horger, Kim Soon. “Formation of Physiologically Relevant Liposomes.” 2013. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/99769.

MLA Handbook (7th Edition):

Horger, Kim Soon. “Formation of Physiologically Relevant Liposomes.” 2013. Web. 08 Jul 2020.

Vancouver:

Horger KS. Formation of Physiologically Relevant Liposomes. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/99769.

Council of Science Editors:

Horger KS. Formation of Physiologically Relevant Liposomes. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/99769

21. Wallace, Rachel. Folate Binding Protein as a Therapeutic Natural Nanotechnology.

Degree: PhD, Chemistry, 2018, University of Michigan

 Serum proteins interact with small molecules and nanoparticles in blood, resulting in protein coronas. Protein coronas influence the bioidentity of the molecules and nanoparticles, playing… (more)

Subjects/Keywords: targeted drug delivery; folate targeted therapy; folate binding protein; folic acid; antifolate therapy; serum proteins; Biological Chemistry; Chemical Engineering; Chemistry; Science (General); Science

…nanoparticles 19 1.5.1. Folate binding protein nanoparticles 20 1.5.2. Conjugation dependent… …interactions with folate binding protein 23 viii 1.5.3. Implications for targeted drug delivery… …Protein – Outlook for Drug Delivery Application 42 2.1. Abstract 42 2.2. Introduction 42… …2.3. The structure, function, and isolation of folate binding protein 44 2.4. The binding… …mechanism of folic acid to folate binding protein 46 2.5. The binding mechanism of folic acid… 

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APA (6th Edition):

Wallace, R. (2018). Folate Binding Protein as a Therapeutic Natural Nanotechnology. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/143895

Chicago Manual of Style (16th Edition):

Wallace, Rachel. “Folate Binding Protein as a Therapeutic Natural Nanotechnology.” 2018. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/143895.

MLA Handbook (7th Edition):

Wallace, Rachel. “Folate Binding Protein as a Therapeutic Natural Nanotechnology.” 2018. Web. 08 Jul 2020.

Vancouver:

Wallace R. Folate Binding Protein as a Therapeutic Natural Nanotechnology. [Internet] [Doctoral dissertation]. University of Michigan; 2018. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/143895.

Council of Science Editors:

Wallace R. Folate Binding Protein as a Therapeutic Natural Nanotechnology. [Doctoral Dissertation]. University of Michigan; 2018. Available from: http://hdl.handle.net/2027.42/143895

22. Rousaki, Aikaterini. Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.

Degree: PhD, Biophysics, 2011, University of Michigan

 Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism… (more)

Subjects/Keywords: NMR; Protein; Drug; Small Molecule; Ligand; Chaperone; Biomedical Engineering; Chemical Engineering; Computer Science; Engineering (General); Materials Science and Engineering; Nuclear Engineering and Radiological Sciences; Biological Chemistry; Complementary and Alternative Medicine; Dentistry; Genetics; Medicine (General); Microbiology and Immunology; Molecular, Cellular and Developmental Biology; Neurosciences; Pathology; Pharmacy and Pharmacology; Physical Medicine and Rehabilitation; Public Health; Chemistry; Ecology and Evolutionary Biology; Mathematics; Natural Resources and Environment; Physics; Science (General); Statistics and Numeric Data; Engineering; Health Sciences; Science

…142 VIII.6.1 Protein preparation 142 VIII.6.2 NMR assignments 143… …154 IX.3.1 Protein Preparation 154 IX.4 Results 154… …References ix 168 List of Tables Table II.1. The protein… …14 Figure II. 5: The Hsp70 protein folding cycle 16 Figure II.6: The… …experiments for the ATP and ADP state of the protein 30 Figure III.1.1… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rousaki, A. (2011). Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/86521

Chicago Manual of Style (16th Edition):

Rousaki, Aikaterini. “Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.” 2011. Doctoral Dissertation, University of Michigan. Accessed July 08, 2020. http://hdl.handle.net/2027.42/86521.

MLA Handbook (7th Edition):

Rousaki, Aikaterini. “Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.” 2011. Web. 08 Jul 2020.

Vancouver:

Rousaki A. Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2020 Jul 08]. Available from: http://hdl.handle.net/2027.42/86521.

Council of Science Editors:

Rousaki A. Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/86521

.