subject:(Prostate Imaging)

Rutgers University

1. Ren, Jian, 1991-. Computer aided analysis of prostate histopathology images.

Degree: PhD, Electrical and Computer Engineering, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/61922/

► Prostate cancer is the most common non-skin related cancer affecting 1 in 7 men in the United States. Treatment of patients with prostate cancer remains… (more)

▼ Prostate cancer is the most common non-skin related cancer affecting 1 in 7 men in the United States. Treatment of patients with prostate cancer remains a difficult decision-making process that requires physicians to balance clinical benefits, life expectancy, morbidities, and potential side effects. Gleason scores have been shown to serve as the best predictors of prostate cancer outcomes. In spite of progress made in trying to standardize the grading process, there still remains approximately a 30% grading discrepancy between the score rendered by general pathologists and those provided by experts while reviewing needle biopsies for Gleason pattern 3 and 4, which accounts for more than 70% of daily prostate tissue slides at most institutions. Therefore, we present computational imaging methods for prostate gland analysis which we will utilize to develop an automated reliable computer-aided Gleason grading system. The inspiration for the project starts from the fact that prostate adenocarcinoma is diagnosed by recognizing certain histology fields clinically. Recently, the Gleason grading criteria used to perform Gleason grading was updated to allow more accurate stratification and higher prognostic discrimination as compared to the traditional grading system. In this thesis work, we have gone beyond Gleason score analysis by introducing survival model assessment to predict patient outcomes. Using whole-slide images (WSIs) generated from biopsy tissues from radical prostatectomy surgical specimens, we utilize deep learning approaches to discover the most promising computational image biomarkers. The proposed method differs from existing survival analysis studies that use individual patches or manually designed protocols to select a set of patches. In contrast to those approaches, we develop an end-to-end methodology to learn from patches that are analyzed sequentially while preserving their inter-spatial relationships within the WSIs. We build the automatically cropped patches from a WSI as a sequence and use the recurrent neural network to generate a salient representative computational biomarker for the WSI. Automatic and accurate Gleason grading of histopathology tissue slides is crucial for reliable prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances because of variation in tissue preparation and staining procedures, thus the predictable model learned from one domain may not be applicable to a new domain, directly. Here we propose to adopt unsupervised domain adaptation to transfer the discriminative knowledge obtained from the source domain to the target domain without requiring labeling of images at the target domain. The adaptation is achieved through adversarial training to find an invariant feature space along with the proposed Siamese architecture on the target domain to add the regularization that is appropriate for the whole-slide images. We validate the method on two prostate cancer datasets and obtain… Advisors/Committee Members: Foran, David J (chair), Hacihaliloglu, Ilker (internal member), Parashar, Manish (internal member), Singer, Eric (outside member), School of Graduate Studies.

Subjects/Keywords: Prostate – Imaging

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APA (6^th Edition):

Ren, Jian, 1. (2019). Computer aided analysis of prostate histopathology images. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/61922/

Chicago Manual of Style (16^th Edition):

Ren, Jian, 1991-. “Computer aided analysis of prostate histopathology images.” 2019. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/61922/.

MLA Handbook (7^th Edition):

Ren, Jian, 1991-. “Computer aided analysis of prostate histopathology images.” 2019. Web. 16 Jan 2021.

Vancouver:

Ren, Jian 1. Computer aided analysis of prostate histopathology images. [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61922/.

Council of Science Editors:

Ren, Jian 1. Computer aided analysis of prostate histopathology images. [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61922/

Ryerson University

2. Sofroni, Ervis. Tissue characterization of prostate cancer using quantitative analysis of low frequency ultrasound.

Degree: 2011, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A924

► Current accepted methodologies used for detection of the prostate rumor involve measurements of prostate specific antigen (PSA) levels, patient age followed by ultrasound guided biopsies… (more)

Subjects/Keywords: Prostate – Magnetic resonance imaging; Prostate – Cancer

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APA (6^th Edition):

Sofroni, E. (2011). Tissue characterization of prostate cancer using quantitative analysis of low frequency ultrasound. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A924

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sofroni, Ervis. “Tissue characterization of prostate cancer using quantitative analysis of low frequency ultrasound.” 2011. Thesis, Ryerson University. Accessed January 16, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A924.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sofroni, Ervis. “Tissue characterization of prostate cancer using quantitative analysis of low frequency ultrasound.” 2011. Web. 16 Jan 2021.

Vancouver:

Sofroni E. Tissue characterization of prostate cancer using quantitative analysis of low frequency ultrasound. [Internet] [Thesis]. Ryerson University; 2011. [cited 2021 Jan 16]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A924.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sofroni E. Tissue characterization of prostate cancer using quantitative analysis of low frequency ultrasound. [Thesis]. Ryerson University; 2011. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A924

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

3. Shakiba, Mojdeh. J-aggregate Nanoparticles as Photoacoustic Contrast Agents for Prostate Cancer Imaging.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/67927

►

Management of early stage prostate cancer (PCa) is plagued with the dilemma between active surveillance that risks progression, and aggressive treatments of potentially indolent disease… (more)

Subjects/Keywords: imaging; nanoparticles; prostate cancer; 0652

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APA (6^th Edition):

Shakiba, M. (2014). J-aggregate Nanoparticles as Photoacoustic Contrast Agents for Prostate Cancer Imaging. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/67927

Chicago Manual of Style (16^th Edition):

Shakiba, Mojdeh. “J-aggregate Nanoparticles as Photoacoustic Contrast Agents for Prostate Cancer Imaging.” 2014. Masters Thesis, University of Toronto. Accessed January 16, 2021. http://hdl.handle.net/1807/67927.

MLA Handbook (7^th Edition):

Shakiba, Mojdeh. “J-aggregate Nanoparticles as Photoacoustic Contrast Agents for Prostate Cancer Imaging.” 2014. Web. 16 Jan 2021.

Vancouver:

Shakiba M. J-aggregate Nanoparticles as Photoacoustic Contrast Agents for Prostate Cancer Imaging. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1807/67927.

Council of Science Editors:

Shakiba M. J-aggregate Nanoparticles as Photoacoustic Contrast Agents for Prostate Cancer Imaging. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/67927

University of Adelaide

4. Waterhouse, David K. Prostate high dose-rate brachytherapy in men with bilateral hip prostheses.

Degree: 2011, University of Adelaide

URL: http://hdl.handle.net/2440/71223

► Bilateral hip prostheses challenge the acquisition of clinically useful treatment planning images for prostate HDR brachytherapy. Prostheses can introduce severe artifact into the principal modalities… (more)

▼ Bilateral hip prostheses challenge the acquisition of clinically useful treatment planning images for prostate HDR brachytherapy. Prostheses can introduce severe artifact into the principal modalities used for HDR prostate brachytherapy imaging – ultrasound, magnetic resonance imaging (MR) and computed tomography (CT). This study aimed to develop a protocol for clinically useful image acquisition that would ensure accurate and reliable implanted needle identification in all patients, including those with bilateral hip prostheses. It was found that in conventional B-mode grey-scale ultrasound images used routinely for image guidance in brachytherapy procedures, artefact such as shadowing and reverberation were confounding factors for accurate HDR brachytherapy treatment planning and delivery. For MR imaging, spatial distortion due to local magnetic field disruption, local signal void within prostheses, and localised areas of high signal intensity near the prostheses all complicated image interpretation for treatment planning. On the other hand, CT images were generally free from distortion and were spatially accurate. The impact of volume averaging on the accuracy of needle tip identification was studied with models of steel implant needles, and CT level and window settings to ensure tip definition to within ±0.7 mm (ensuring dosimetric accuracy of better than 0.7%), were determined. In a study of 91 patients with stainless steel needle implants and without hip prostheses, the mean caudal displacement before adjustment was 5.4 mm (SD 3.3 mm). Plastic needle implants in 14 patients with bilateral hip prostheses was examined, and the mean caudal displacement before adjustment was 1.6 mm (SD 3.1 mm). Nitinol marker wires developed for use in plastic needles implanted into prosthesis patients were found to be superior when compared with standard rigid obturators. The wires, with the same flex properties as an active Ir-192 source wire, assist accurate identification of needle tips and may also provide an improved match to the treatment geometry for treatment planning purposes. The impact of stainless steel and plastic needle movement on treatment efficacy was studied via Tumour Control Probability (TCP) calculations using three different TCP models and simulated brachytherapy treatment plans. This study showed that it was feasible to maintain displacements less than 3 mm, and that if this limit were adopted, it would result in most patients having TCP close to or greater than 95% of the original. Advisors/Committee Members: Pollard, Judith Mary (advisor), Ebert, Martin Andrew (advisor), Haworth, Annette (advisor), School of Chemistry and Physics (school).

Subjects/Keywords: brachytherapy; prostate; imaging; hip prostheses

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APA (6^th Edition):

Waterhouse, D. K. (2011). Prostate high dose-rate brachytherapy in men with bilateral hip prostheses. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/71223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Waterhouse, David K. “Prostate high dose-rate brachytherapy in men with bilateral hip prostheses.” 2011. Thesis, University of Adelaide. Accessed January 16, 2021. http://hdl.handle.net/2440/71223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Waterhouse, David K. “Prostate high dose-rate brachytherapy in men with bilateral hip prostheses.” 2011. Web. 16 Jan 2021.

Vancouver:

Waterhouse DK. Prostate high dose-rate brachytherapy in men with bilateral hip prostheses. [Internet] [Thesis]. University of Adelaide; 2011. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2440/71223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Waterhouse DK. Prostate high dose-rate brachytherapy in men with bilateral hip prostheses. [Thesis]. University of Adelaide; 2011. Available from: http://hdl.handle.net/2440/71223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

5. Barrett, Tristan. Functional Imaging to enable more accurate localisation and characterisation of prostate tumours.

Degree: MD, 2018, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/274160

► Abstract Prostate cancer is the leading cause of cancer death in men after skin cancer, with an incidence expected to double by 2030 mainly due… (more)

Subjects/Keywords: Prostate cancer; Functional Imaging; MRI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barrett, T. (2018). Functional Imaging to enable more accurate localisation and characterisation of prostate tumours. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/274160

Chicago Manual of Style (16^th Edition):

Barrett, Tristan. “Functional Imaging to enable more accurate localisation and characterisation of prostate tumours.” 2018. Doctoral Dissertation, University of Cambridge. Accessed January 16, 2021. https://www.repository.cam.ac.uk/handle/1810/274160.

MLA Handbook (7^th Edition):

Barrett, Tristan. “Functional Imaging to enable more accurate localisation and characterisation of prostate tumours.” 2018. Web. 16 Jan 2021.

Vancouver:

Barrett T. Functional Imaging to enable more accurate localisation and characterisation of prostate tumours. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Jan 16]. Available from: https://www.repository.cam.ac.uk/handle/1810/274160.

Council of Science Editors:

Barrett T. Functional Imaging to enable more accurate localisation and characterisation of prostate tumours. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://www.repository.cam.ac.uk/handle/1810/274160

University of Minnesota

6. Glumac, Paige M. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.

Degree: PhD, Pharmacology, 2019, University of Minnesota

URL: http://hdl.handle.net/11299/206273

► An increasing number of men are developing a lethal, non-androgen receptor (AR) driven form of prostate cancer (PCa) known as aggressive variant prostate cancer (AVPC).… (more)

Subjects/Keywords: CD133; PET imaging; Prostate Cancer

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APA (6^th Edition):

Glumac, P. M. (2019). Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/206273

Chicago Manual of Style (16^th Edition):

Glumac, Paige M. “Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.” 2019. Doctoral Dissertation, University of Minnesota. Accessed January 16, 2021. http://hdl.handle.net/11299/206273.

MLA Handbook (7^th Edition):

Glumac, Paige M. “Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer.” 2019. Web. 16 Jan 2021.

Vancouver:

Glumac PM. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/11299/206273.

Council of Science Editors:

Glumac PM. Targeting CD133 In Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/206273

Louisiana State University

7. Steiner, Joseph Robert. Endorectal Digital Prostate Tomosynthesis.

Degree: PhD, Health and Medical Physics, 2018, Louisiana State University

URL: https://digitalcommons.lsu.edu/gradschool_dissertations/4582

► Several areas of prostate cancer (PCa) management, such as imaging permanent brachytherapy implants or small, aggressive lesions, benefit from high image resolution. Current PCa… (more)

▼ Several areas of prostate cancer (PCa) management, such as imaging permanent brachytherapy implants or small, aggressive lesions, benefit from high image resolution. Current PCa imaging methods can have inadequate resolution for imaging these areas. Endorectal digital prostate tomosynthesis (endoDPT), an imaging method that combines an external x-ray source and an endorectal x-ray sensor, can produce three-dimensional images of the prostate region that have high image resolution compared to typical methods. This high resolution may improve PCa management and increase positive outcomes in affected men. This dissertation presents the initial development of endoDPT, including system design, image quality assessment, and examples of possible applications to prostate imaging. Experiments using computational phantoms, physical phantoms, and canine prostate specimens were conducted. Initial system design was performed computationally and three methods of endoDPT image reconstruction were developed: shift and add (SAA), backprojection (BP), and filtered BP (FBP). A physical system was developed using an XDR intraoral x-ray sensor and a GE radiography unit. The resolution and radiation dose of endoDPT were measured and compared to a GE CT scanner. Canine prostate specimens that approximated clinical cases of PCa management were imaged and compared using endoDPT, the above CT scanner, and a GE MRI scanner. This study found that the resolution of endoDPT was significantly higher than CT. The radiation dose of endoDPT was significantly lower than CT in the regions of the phantom that were not in the endoDPT field of view (FoV). Inside the endoDPT FoV, the radiation dose ranged from significantly less than to significantly greater than CT. The endoDPT images of the canine prostate specimens demonstrated qualitative improvements in resolution compared to CT and MRI, but endoDPT had difficulty in visualizing larger structures, such as the prostate border. Overall, this study has demonstrated endoDPT has high image resolution compared to typical methods of PCa imaging. Future work will be focused on development of a prototype system that improves scanning efficiency that can be used to optimize endoDPT and perform pre-clinical studies.

Subjects/Keywords: prostate cancer; high-resolution imaging

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APA (6^th Edition):

Steiner, J. R. (2018). Endorectal Digital Prostate Tomosynthesis. (Doctoral Dissertation). Louisiana State University. Retrieved from https://digitalcommons.lsu.edu/gradschool_dissertations/4582

Chicago Manual of Style (16^th Edition):

Steiner, Joseph Robert. “Endorectal Digital Prostate Tomosynthesis.” 2018. Doctoral Dissertation, Louisiana State University. Accessed January 16, 2021. https://digitalcommons.lsu.edu/gradschool_dissertations/4582.

MLA Handbook (7^th Edition):

Steiner, Joseph Robert. “Endorectal Digital Prostate Tomosynthesis.” 2018. Web. 16 Jan 2021.

Vancouver:

Steiner JR. Endorectal Digital Prostate Tomosynthesis. [Internet] [Doctoral dissertation]. Louisiana State University; 2018. [cited 2021 Jan 16]. Available from: https://digitalcommons.lsu.edu/gradschool_dissertations/4582.

Council of Science Editors:

Steiner JR. Endorectal Digital Prostate Tomosynthesis. [Doctoral Dissertation]. Louisiana State University; 2018. Available from: https://digitalcommons.lsu.edu/gradschool_dissertations/4582

Rutgers University

8. Chappelow, Jonathan, 1980-. Multimodal image registration using multivariate information theoretic similarity measures: applications to prostate cancer diagnosis and targeted treatment.

Degree: PhD, Biomedical Engineering, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061604

►

Multimodal and multiprotocol image registration refers to the process of alignment of two or more images obtained from different imaging modalities (e.g. digitized histology and… (more)

▼

Multimodal and multiprotocol image registration refers to the process of alignment of two or more images obtained from different imaging modalities (e.g. digitized histology and MRI) and protocols (e.g. T2-w and PD-w MRI). Registration is a critical component in medical applications including image guided surgery, image fusion for cancer diagnosis and treatment planning, and automated tissue annotation. However, registration is often complicated on account of differences in both the image intensities and the shape of the underlying anatomy. For example, non-linear differences in the overall shape of the prostate between in vivo MRI and ex vivo whole mount histology (WMH) often exist as a result of the presence of an endorectal coil during pre-operative MR imaging and deformations to the specimen during slide preparation. To overcome these challenges, we present new registration techniques termed Combined Feature Ensemble Mutual Information (COFEMI) and Collection of Image-derived Non-linear Attributes for Registration Using Splines (COLLINARUS). The goal COFEMI is to provide a similarity measure that is driven by unique low level textural features, for registration that is more robust to intensity artifacts and modality differences than measures restricted to intensities alone. COLLINARUS offers the robustness of COFEMI to artifacts and modality differences, while allowing fully automated non-linear image warping at multiple scales via a hierarchical B-spline mesh grid. In addition, since routine clinical imaging procedures often involve the acquisition of multiple imaging protocols, we present a technique termed Multi-attribute Combined Mutual Information (MACAMI) to leverage the availability of multiple image sets to improve registration. We apply our registration techniques to a unique clinical dataset comprising 150 sets of in vivo MRI and post-operative WMH images from 25 patient studies in order to retrospectively establish the spatial extent of prostate cancer (CaP) on structural (T2-w) and functional (DCE) in vivo MRI. Accurate mapping of CaP on MRI is used to facilitate the development and evaluation of a system for computer-assisted detection (CAD) of CaP on multiprotocol MRI. We also demonstrate our registration and CAD algorithms in developing radiation therapy treatment plans that provide dose escalation to CaP by elastically registering diagnostic MRI with planning CT.

Advisors/Committee Members: Chappelow, Jonathan, 1980- (author), Madabhushi, Anant (chair), Bhanot, Gyan (internal member), Boustany, Nada (internal member), Bloch, B Nicolas (outside member), Tomaszewski, John E (outside member), Rosen, Mark (outside member).

Subjects/Keywords: Imaging systems in medicine; Prostate—Cancer – Imaging; Prostate—Cancer – Treatment

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APA (6^th Edition):

Chappelow, Jonathan, 1. (2011). Multimodal image registration using multivariate information theoretic similarity measures: applications to prostate cancer diagnosis and targeted treatment. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061604

Chicago Manual of Style (16^th Edition):

Chappelow, Jonathan, 1980-. “Multimodal image registration using multivariate information theoretic similarity measures: applications to prostate cancer diagnosis and targeted treatment.” 2011. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061604.

MLA Handbook (7^th Edition):

Chappelow, Jonathan, 1980-. “Multimodal image registration using multivariate information theoretic similarity measures: applications to prostate cancer diagnosis and targeted treatment.” 2011. Web. 16 Jan 2021.

Vancouver:

Chappelow, Jonathan 1. Multimodal image registration using multivariate information theoretic similarity measures: applications to prostate cancer diagnosis and targeted treatment. [Internet] [Doctoral dissertation]. Rutgers University; 2011. [cited 2021 Jan 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061604.

Council of Science Editors:

Chappelow, Jonathan 1. Multimodal image registration using multivariate information theoretic similarity measures: applications to prostate cancer diagnosis and targeted treatment. [Doctoral Dissertation]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061604

University of California – San Francisco

9. Liang, Carmin Jia Min. Predicting Disease Progression with Multiparametric Magnetic Resonance Imaging of Prostate Cancer Managed with Active Surveillance.

Degree: Biomedical Imaging, 2012, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/73p3b2pk

► Prostate cancer is currently the most prevalent noncutaneous cancer in males. An increase in the number of men diagnosed with indolent, organ-confined disease has lead… (more)

▼ Prostate cancer is currently the most prevalent noncutaneous cancer in males. An increase in the number of men diagnosed with indolent, organ-confined disease has lead to the increasing numbers of patients and their physicians selecting active surveillance or "delayed definitive treatment" as a viable approach for managing prostate cancer. However, the selection of appropriate patients for active surveillance has been confounded by sampling errors associated with transrectal ultrasound guided biopsies as well as accurate clinical and imaging biomarkers that predict for aggressive, progressive disease at diagnosis. Multiparametric magnetic resonance (MR) imaging may assist in overcoming this problem; it allows for the identification of the whole gland and a combination of T2-weighted MR imaging, proton MR spectroscopic imaging (1H MRSI), and diffusion-weighted imaging (DWI) can be used to better characterize the aggressiveness of intraglandular cancer at diagnosis. In this retrospective study, we quantitatively analyzed multiparametric MR images from a cohort of active surveillance patients (N=119) to determine the combination of MR imaging techniques that best predicted disease progression on active surveillance. Fifty-nine of 119 patients progressed within 43 ± 32 months on active surveillance. Receiver-operator characteristic (ROC) curve analysis indicated that all three techniques (T2 MRI, MRSI, DWI) demonstrated similar modest accuracies in predicting progression on AS (AUC of 0.59, 0.63 and 0.61, respectively). The best prediction of prostate cancer progression in AS patients was when all three techniques were positive for cancer presence, yielding an odds ratio for progression of 2.91 (95% CI 1.19 - 7.08) as compared to all other findings. Whereas a negative finding for all 3 tests for patients that were appropriate for AS yielded an odds ratio for no progression of 2.84 (95% CI = 1.26 - 6.37) as compared to all other findings. In conclusion, multiparametric MR imaging could play a valuable role in better selecting patients for active surveillance.

Subjects/Keywords: Medical imaging and radiology; active surveillance; magnetic resonance imaging; multiparametric imaging; prostate cancer; prostate diffusion weighted imaging; prostate MRSI

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APA (6^th Edition):

Liang, C. J. M. (2012). Predicting Disease Progression with Multiparametric Magnetic Resonance Imaging of Prostate Cancer Managed with Active Surveillance. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/73p3b2pk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liang, Carmin Jia Min. “Predicting Disease Progression with Multiparametric Magnetic Resonance Imaging of Prostate Cancer Managed with Active Surveillance.” 2012. Thesis, University of California – San Francisco. Accessed January 16, 2021. http://www.escholarship.org/uc/item/73p3b2pk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liang, Carmin Jia Min. “Predicting Disease Progression with Multiparametric Magnetic Resonance Imaging of Prostate Cancer Managed with Active Surveillance.” 2012. Web. 16 Jan 2021.

Vancouver:

Liang CJM. Predicting Disease Progression with Multiparametric Magnetic Resonance Imaging of Prostate Cancer Managed with Active Surveillance. [Internet] [Thesis]. University of California – San Francisco; 2012. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/73p3b2pk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liang CJM. Predicting Disease Progression with Multiparametric Magnetic Resonance Imaging of Prostate Cancer Managed with Active Surveillance. [Thesis]. University of California – San Francisco; 2012. Available from: http://www.escholarship.org/uc/item/73p3b2pk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

East Carolina University

10. Ruiz, Brian. Evaluation of Magnetic Resonance Imaging in Prostate Radiotherapy for Improved Treatment Outcomes.

Degree: PhD, PHD-Biomedical Physics, 2019, East Carolina University

URL: http://hdl.handle.net/10342/7226

► External beam radiation therapy is among the most common modalities of curative treatment for prostate cancer and has evolved substantially with the inclusion of multimodality… (more)

▼ External beam radiation therapy is among the most common modalities of curative treatment for prostate cancer and has evolved substantially with the inclusion of multimodality imaging in treatment planning. It has been documented that treatment planning with a magnetic resonance image (MRI) delineated prostate registered to computed tomography (CT) may reduce bladder and rectal toxicity due to a reduction in overall prostate volume as seen on MRI compared to CT. However, due to the smaller target volume when delineating prostate on MRI, margins may be too tight as compared to CT delineation, potentially reducing tumor control probability. In this dissertation research we hypothesized that a unique MRI-based target expansion method based on exclusions of organs-at-risk may provide adequate margins to maintain tumor control probability yet limit normal tissue toxicity as compared to CT-based delineation. We developed and clinically implemented an MRI-based expansion method, which excluded organs-at-risk when performing a 5 mm isotropic (except 4 mm posterior) expansion from gross tumor volume to clinical target volume (CTV), followed by an isotropic 5 mm expansion to generate the planning target volume (PTV). To test our hypothesis, ten retrospective patients' treatment plans using MRI-based method were first compared to treatment plans using CT-delineated prostate with CTV-to-PTV expansion of isotropic 8 mm, except for a 5 mm posterior expansion. Patients were treated to 79.2 Gy in 44 fractions uniformly via intensity modulated radiotherapy. Radiobiological model-based calculations were then performed to determine tumor control probability and normal tissue complication probability for both methods. In addition, daily image guidance was analyzed for prostate shifts via fiducial tracking to ensure full target coverage during treatment. Under IRB approved protocol, we retrospectively evaluated 51 patients treated with the MRI-based method for acute bladder and rectal toxicity with CTC-AE version 4.0 used for scoring, including analysis of prostate-specific antigen (PSA). Treatment planning comparison showed that our MRI-based method PTV volume was similar within 3.79% of conventional CT-based PTV volume. Bladder QUANTEC constraints were on average less for the MRI-based method as compared to the conventional CT-based method and observed as statistically significant with 2.64% reduction in volume receiving 65 Gy. Rectal constraints appeared to follow the same trend. Radiobiological calculated tumor control probability of the MRI-based method was found comparable to CT-based methods. Statistically significant decrease in bladder normal tissue complication probability was observed in the MRI- based method. Analysis of shift data showed prostate anatomy was within proposed PTV margins. Outcomes data collected showed 65% and 100% of patients studied experienced Grade 0/1 bladder and rectal acute toxicity respectively. Grade 2 bladder toxicity was indicated in the remaining 35% of patients studied with no Grade 3… Advisors/Committee Members: Feng, Yuanming (advisor).

Subjects/Keywords: Prostate Radiotherapy; Treatment Outcomes; Magnetic resonance imaging; Prostate – Cancer

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APA (6^th Edition):

Ruiz, B. (2019). Evaluation of Magnetic Resonance Imaging in Prostate Radiotherapy for Improved Treatment Outcomes. (Doctoral Dissertation). East Carolina University. Retrieved from http://hdl.handle.net/10342/7226

Chicago Manual of Style (16^th Edition):

Ruiz, Brian. “Evaluation of Magnetic Resonance Imaging in Prostate Radiotherapy for Improved Treatment Outcomes.” 2019. Doctoral Dissertation, East Carolina University. Accessed January 16, 2021. http://hdl.handle.net/10342/7226.

MLA Handbook (7^th Edition):

Ruiz, Brian. “Evaluation of Magnetic Resonance Imaging in Prostate Radiotherapy for Improved Treatment Outcomes.” 2019. Web. 16 Jan 2021.

Vancouver:

Ruiz B. Evaluation of Magnetic Resonance Imaging in Prostate Radiotherapy for Improved Treatment Outcomes. [Internet] [Doctoral dissertation]. East Carolina University; 2019. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10342/7226.

Council of Science Editors:

Ruiz B. Evaluation of Magnetic Resonance Imaging in Prostate Radiotherapy for Improved Treatment Outcomes. [Doctoral Dissertation]. East Carolina University; 2019. Available from: http://hdl.handle.net/10342/7226

San Jose State University

11. Pourfathi, Mehrdad. Ultrasound Strain Imaging Using Sector Arrays For Monitoring Prostate Ablation Therapy.

Degree: MS, Electrical Engineering, 2011, San Jose State University

URL: https://doi.org/10.31979/etd.dvcc-7uuv ; https://scholarworks.sjsu.edu/etd_theses/4071

► Thermal ablation treatment is a relatively new method for prostate cancer therapy, where high energy focused ultrasound is used to thermally coagulate cancerous tissue.… (more)

Subjects/Keywords: Elastography; Hyperthermia; Prostate Cancer; Strain Imaging; Ultrasound

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APA (6^th Edition):

Pourfathi, M. (2011). Ultrasound Strain Imaging Using Sector Arrays For Monitoring Prostate Ablation Therapy. (Masters Thesis). San Jose State University. Retrieved from https://doi.org/10.31979/etd.dvcc-7uuv ; https://scholarworks.sjsu.edu/etd_theses/4071

Chicago Manual of Style (16^th Edition):

Pourfathi, Mehrdad. “Ultrasound Strain Imaging Using Sector Arrays For Monitoring Prostate Ablation Therapy.” 2011. Masters Thesis, San Jose State University. Accessed January 16, 2021. https://doi.org/10.31979/etd.dvcc-7uuv ; https://scholarworks.sjsu.edu/etd_theses/4071.

MLA Handbook (7^th Edition):

Pourfathi, Mehrdad. “Ultrasound Strain Imaging Using Sector Arrays For Monitoring Prostate Ablation Therapy.” 2011. Web. 16 Jan 2021.

Vancouver:

Pourfathi M. Ultrasound Strain Imaging Using Sector Arrays For Monitoring Prostate Ablation Therapy. [Internet] [Masters thesis]. San Jose State University; 2011. [cited 2021 Jan 16]. Available from: https://doi.org/10.31979/etd.dvcc-7uuv ; https://scholarworks.sjsu.edu/etd_theses/4071.

Council of Science Editors:

Pourfathi M. Ultrasound Strain Imaging Using Sector Arrays For Monitoring Prostate Ablation Therapy. [Masters Thesis]. San Jose State University; 2011. Available from: https://doi.org/10.31979/etd.dvcc-7uuv ; https://scholarworks.sjsu.edu/etd_theses/4071

University of Waterloo

12. Lui, Dorothy. Monte Carlo Framework for Prostate Cancer Correction and Reconstruction in Endorectal Multi-parametric MRI.

Degree: 2014, University of Waterloo

URL: http://hdl.handle.net/10012/8589

► Prostate cancer is one of the leading causes of cancer death in the male population. The detection of prostate cancer using imaging has been challenging… (more)

▼ Prostate cancer is one of the leading causes of cancer death in the male population. The detection of prostate cancer using imaging has been challenging until recently. Multi-parametric MRI has been shown to allow accurate localization of the cancers and can help direct biopsies to cancer foci which is required to plan treatment. The interpretation of MRI, however, requires a high level of expertise and review of large multi-parametric data sets. An endorectal receiver coil is often used to improve signal-to-noise ratio (SNR) and aid in detection of smaller cancer foci. Despite increased SNR, intensity bias fields can exist where nearest the endorectal coil the signal is greater than those regions farther from the coil. Weak delineation of the prostate as well as poor prostate gland visualization can greatly impact the ease and accuracy of diagnosis. For this reason, there is a need for an automated system which can correct endorectal multi-parametric MRI for enhanced visualization. A framework using Monte Carlo sampling techniques has been developed for prostate cancer correction and reconstruction in endorectal multi-parametric MRI. Its performance against state-of-the-art approaches demonstrate improved results for visualization and prostate delineation. The first step in the proposed framework involves reconstructing an intensity bias-free image. Using importance-weighted Monte Carlo sampling, the intensity bias field is estimated to approximate the bias-free result. However, the reconstruction is still pervaded by noise which becomes amplified and non-stationary as a result of intensity bias correction. The second step in the framework applies a spatially-adaptive Rician distributed Monte Carlo sampling approach while accounting for the endorectal coil's underlying SNR characteristics. To evaluate the framework, the individual steps are compared against state-of-the-art approaches using phantoms and real patient data to quantify visualization improvement. The intensity bias correction technique is critiqued based on detail preservation and delineation of the prostate from the background as well as improvement in tumor identification. The noise compensation approach is considered based on the noise suppression, contrast of tissue as well as preservation of details and texture. Utilizing quantitative and qualitative metrics in addition to visual analysis, the experimental results demonstrated that the proposed framework allows for improved visualization, with increased delineation of the prostate and preservation of tissue textures and details. This allows radiologists to more easily identify characteristics of cancerous and healthy tissue leading to more accurate and confident diagnoses.

Subjects/Keywords: image processing; magnetic resonance imaging; prostate cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lui, D. (2014). Monte Carlo Framework for Prostate Cancer Correction and Reconstruction in Endorectal Multi-parametric MRI. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/8589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lui, Dorothy. “Monte Carlo Framework for Prostate Cancer Correction and Reconstruction in Endorectal Multi-parametric MRI.” 2014. Thesis, University of Waterloo. Accessed January 16, 2021. http://hdl.handle.net/10012/8589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lui, Dorothy. “Monte Carlo Framework for Prostate Cancer Correction and Reconstruction in Endorectal Multi-parametric MRI.” 2014. Web. 16 Jan 2021.

Vancouver:

Lui D. Monte Carlo Framework for Prostate Cancer Correction and Reconstruction in Endorectal Multi-parametric MRI. [Internet] [Thesis]. University of Waterloo; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10012/8589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lui D. Monte Carlo Framework for Prostate Cancer Correction and Reconstruction in Endorectal Multi-parametric MRI. [Thesis]. University of Waterloo; 2014. Available from: http://hdl.handle.net/10012/8589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

13. Sun, Jidi. Development of magnetic resonance imaging based prostate treatment planning.

Degree: PhD, 2015, University of Newcastle

URL: http://hdl.handle.net/1959.13/1308318

►

Research Doctorate - Doctor of Philosophy (PhD)

Radiotherapy is one of the main methods used to treat prostate cancer. Radiotherapy treatment relies on accurate planning… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Radiotherapy is one of the main methods used to treat prostate cancer. Radiotherapy treatment relies on accurate planning and simulation before any radiation is administered. Currently this is mainly based on CT (computed tomography) imaging, although MR (magnetic resonance) imaging provides superior soft-tissue contrast and is therefore often used to assist with accurate organ delineation. The overall treatment planning workflow and performance can be improved if the entire workflow is solely performed using MR images. In order to achieve such MR-only treatment planning, three main challenges need to be overcome: 1) the geometric accuracy of MR images needs to be assured ; 2) the MR simulator needs to be commissioned and evaluated ; 3) electron density information required for dose calculation needs to be generated from MR images. This thesis examines each of these challenges. First, a pelvic shape phantom was used to quantify the geometric distortion arising in prostate treatment. The CT image was acquired as the gold reference and the distortion of the MR image was corrected with the vendor’s built-in algorithm. Using the image registration method, the maximum geometric distortion was reduced from nearly 8 mm to within the radiotherapy tolerance level. Second, commercial radiotherapy-dedicated equipment was implemented on the Siemens Skyra 3 Tesla MR scanner. This involved a hard flat tabletop which mimicked the flat radiotherapy treatment table, and coil mounts to lift the MR coil above the patient’s body and minimise coil-induced disagreement between the MR planning and treatment geometry. A reduction in image quality was observed on the MR simulator, but no clinically significant difference was found in the accuracy of organ delineation. Furthermore, use of the MR simulator eliminated patient positioning error associated with conventional MR scanner design and thus reduced the systematic dosimetric error. The entire workflow of MR-based planning was tested using an anthropomorphic phantom and no significant difference was found between MR- and CT-based plans. Finally, substitute (also known as synthetic or pseudo) sCT images were generated from MR images using a multi-atlas local weighted voting method. Validation was conducted on 39 patients and the sCT images were in high level agreement with the CT images. In summary, MR-based radiotherapy planning for treating prostate cancer has been thoroughly tested and evaluated in this study. This may provide an important stepping stone for the future clinical implementation.

Advisors/Committee Members: University of Newcastle. Faculty of Science & Information Technology, School of Mathematical and Physical Sciences.

Subjects/Keywords: radiotherapy; magnetic resonance imaging; MRI; prostate cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sun, J. (2015). Development of magnetic resonance imaging based prostate treatment planning. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1308318

Chicago Manual of Style (16^th Edition):

Sun, Jidi. “Development of magnetic resonance imaging based prostate treatment planning.” 2015. Doctoral Dissertation, University of Newcastle. Accessed January 16, 2021. http://hdl.handle.net/1959.13/1308318.

MLA Handbook (7^th Edition):

Sun, Jidi. “Development of magnetic resonance imaging based prostate treatment planning.” 2015. Web. 16 Jan 2021.

Vancouver:

Sun J. Development of magnetic resonance imaging based prostate treatment planning. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1959.13/1308318.

Council of Science Editors:

Sun J. Development of magnetic resonance imaging based prostate treatment planning. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1308318

14. Starobinets, Olga. Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate.

Degree: Bioengineering, 2017, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/6p38157c

► Prostate cancer is extremely common. With recent advancements in cancer detection, an increasing number of men at a younger age face the difficult choice between… (more)

Subjects/Keywords: Biomedical engineering; Histopathology; Imaging; MRI; Multiparametric; Prostate

11 more images…

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APA (6^th Edition):

Starobinets, O. (2017). Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/6p38157c

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Starobinets, Olga. “Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate.” 2017. Thesis, University of California – San Francisco. Accessed January 16, 2021. http://www.escholarship.org/uc/item/6p38157c.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Starobinets, Olga. “Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate.” 2017. Web. 16 Jan 2021.

Vancouver:

Starobinets O. Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate. [Internet] [Thesis]. University of California – San Francisco; 2017. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/6p38157c.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Starobinets O. Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate. [Thesis]. University of California – San Francisco; 2017. Available from: http://www.escholarship.org/uc/item/6p38157c

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Saskatchewan

15. Keith, Jay D 1992-. REALIZATION OF A CANINE POSITIONING DEVICE FOR IN SITU PROSTATE PHASE CONTRAST – COMPUTED TOMOGRAPHY IMAGING.

Degree: 2017, University of Saskatchewan

URL: http://hdl.handle.net/10388/7846

► Background: Worldwide, prostate cancer (PCa) is the most commonly diagnosed non-skin cancer in men. The current diagnostic standard of PCa requires invasive procedures such as… (more)

Subjects/Keywords: Phase-Contrast Computed Tomography; Prostate Cancer; Canine Prostate; In Situ Imaging; Synchrotron Imaging; Biomedical Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keith, J. D. 1. (2017). REALIZATION OF A CANINE POSITIONING DEVICE FOR IN SITU PROSTATE PHASE CONTRAST – COMPUTED TOMOGRAPHY IMAGING. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/7846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Keith, Jay D 1992-. “REALIZATION OF A CANINE POSITIONING DEVICE FOR IN SITU PROSTATE PHASE CONTRAST – COMPUTED TOMOGRAPHY IMAGING.” 2017. Thesis, University of Saskatchewan. Accessed January 16, 2021. http://hdl.handle.net/10388/7846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Keith, Jay D 1992-. “REALIZATION OF A CANINE POSITIONING DEVICE FOR IN SITU PROSTATE PHASE CONTRAST – COMPUTED TOMOGRAPHY IMAGING.” 2017. Web. 16 Jan 2021.

Vancouver:

Keith JD1. REALIZATION OF A CANINE POSITIONING DEVICE FOR IN SITU PROSTATE PHASE CONTRAST – COMPUTED TOMOGRAPHY IMAGING. [Internet] [Thesis]. University of Saskatchewan; 2017. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10388/7846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Keith JD1. REALIZATION OF A CANINE POSITIONING DEVICE FOR IN SITU PROSTATE PHASE CONTRAST – COMPUTED TOMOGRAPHY IMAGING. [Thesis]. University of Saskatchewan; 2017. Available from: http://hdl.handle.net/10388/7846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Wollongong

16. Han, Zhangbo. Real-time source tracking for quality assurance in HDR prostate brachytherapy.

Degree: PhD, 2015, University of Wollongong

URL: ; https://ro.uow.edu.au/theses/4531

► High dose rate (HDR) brachytherapy is the preferred treatment option for clinically localised prostate cancer. The underlying principle is simple: temporarily inserting a highly… (more)

Subjects/Keywords: Prostate cancer; HDR brachytherapy; in-body imaging; pinhole imaging

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APA (6^th Edition):

Han, Z. (2015). Real-time source tracking for quality assurance in HDR prostate brachytherapy. (Doctoral Dissertation). University of Wollongong. Retrieved from ; https://ro.uow.edu.au/theses/4531

Chicago Manual of Style (16^th Edition):

Han, Zhangbo. “Real-time source tracking for quality assurance in HDR prostate brachytherapy.” 2015. Doctoral Dissertation, University of Wollongong. Accessed January 16, 2021. ; https://ro.uow.edu.au/theses/4531.

MLA Handbook (7^th Edition):

Han, Zhangbo. “Real-time source tracking for quality assurance in HDR prostate brachytherapy.” 2015. Web. 16 Jan 2021.

Vancouver:

Han Z. Real-time source tracking for quality assurance in HDR prostate brachytherapy. [Internet] [Doctoral dissertation]. University of Wollongong; 2015. [cited 2021 Jan 16]. Available from: ; https://ro.uow.edu.au/theses/4531.

Council of Science Editors:

Han Z. Real-time source tracking for quality assurance in HDR prostate brachytherapy. [Doctoral Dissertation]. University of Wollongong; 2015. Available from: ; https://ro.uow.edu.au/theses/4531

University of California – San Francisco

17. Qin, Hecong. In Vivo Hyperpolarized Carbon-13 Diffusion Weighted MRI Measures Lactate Metabolism and Transport in Prostate Cancer.

Degree: Biomedical Imaging, 2015, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/8cq5f3bb

► Prostate cancer is a heterogeneous group of tumors ranging from clinicallyinsignificant to lethally malignant. The clinical management of prostate cancer is challenging due to the… (more)

▼ Prostate cancer is a heterogeneous group of tumors ranging from clinicallyinsignificant to lethally malignant. The clinical management of prostate cancer is challenging due to the lack of accurate assessment of cancer aggressiveness. Hyperpolarized magnetic resonance imaging (MRI) has enabled real-time measurement of metabolism, and has shown great promise for cancer diagnosis, staging and assessing treatment response in both pre- clinical and clinical studies. Aggressive prostate cancer overproduces lactate and overexpresses MCT4, the transporter primarily responsible for lactate efflux, resulting in acidification of the extracellular space and conferring a poor prognosis. In this pilot study, hyperpolarized diffusion weighted MRI was used to elucidate the intra- and extracellular distribution of metabolites, which can infer lactate efflux, and tumor microstructural environment. Transgenic adenocarcinoma mouse prostate (TRAMP) models of different stages were injected with hyperpolarized pyruvate; then pyruvate and lactate were excited with a single- band spectral-spatial RF pulse, followed by a single-shot, double spin-echo flyback echo planar imaging (EPI) readout. Four b-values were acquired per metabolite, ranging from 25-1000 s • mm^-2. Data were corrected for RF utilization and fit voxel-wise to a monoexponential decay to generate apparent diffusion coefficient (ADC) maps for each metabolite. We found that the in vivo lactate ADC is close to the ex vivo extracellular ADC, rather than the intracellular ADC. We also found lactate ADC in late-stage tumors (0.65 ± 0.11 mm • s^−1 , n=4) is higher than early-stage (0.46 mm² • s^−1 , n=1), indicating there is increased lactate efflux in aggressive cancer. In conclusion, we demonstrated that hyperpolarized diffusion weighted MRI can provide insight into metabolite compartmentalization and lactate efflux in the prostate tumor, and potentially assess cancer aggressiveness and therapeutic changes in a rapid, non-invasive manner.

Subjects/Keywords: Medical imaging; Diffusion; Hyperpolarization; Lactate Transport; Metabolic Imaging; MRI; Prostate Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Qin, H. (2015). In Vivo Hyperpolarized Carbon-13 Diffusion Weighted MRI Measures Lactate Metabolism and Transport in Prostate Cancer. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/8cq5f3bb

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Qin, Hecong. “In Vivo Hyperpolarized Carbon-13 Diffusion Weighted MRI Measures Lactate Metabolism and Transport in Prostate Cancer.” 2015. Thesis, University of California – San Francisco. Accessed January 16, 2021. http://www.escholarship.org/uc/item/8cq5f3bb.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Qin, Hecong. “In Vivo Hyperpolarized Carbon-13 Diffusion Weighted MRI Measures Lactate Metabolism and Transport in Prostate Cancer.” 2015. Web. 16 Jan 2021.

Vancouver:

Qin H. In Vivo Hyperpolarized Carbon-13 Diffusion Weighted MRI Measures Lactate Metabolism and Transport in Prostate Cancer. [Internet] [Thesis]. University of California – San Francisco; 2015. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/8cq5f3bb.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Qin H. In Vivo Hyperpolarized Carbon-13 Diffusion Weighted MRI Measures Lactate Metabolism and Transport in Prostate Cancer. [Thesis]. University of California – San Francisco; 2015. Available from: http://www.escholarship.org/uc/item/8cq5f3bb

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Fargier-Voiron, Marie. Performances d’un dispositif d’imagerie ultrasonore pour le suivi des mouvements prostatiques en radiothérapie : Ultrasound imaging modality for motion monitoring during prostate cancer radiotherapy.

Degree: Docteur es, Electronique, electrotechnique, automatique, 2015, INSA Lyon

URL: http://www.theses.fr/2015ISAL0119

►

Suite à l’émergence de protocoles d’hypofractionnement à visée curative comportant un risque accru de toxicité, il devient fondamental d’arriver à augmenter la précision dans la… (more)

▼

Suite à l’émergence de protocoles d’hypofractionnement à visée curative comportant un risque accru de toxicité, il devient fondamental d’arriver à augmenter la précision dans la délivrance de la dose. Les mouvements internes entre et pendant les séances d’irradiation peuvent devenir un facteur limitant majeur pour la qualité de l’irradiation des localisations tumorales mobiles. C’est le cas pour le cancer de la prostate pour lequel l’hypofractionnement est une voie prometteuse bien qu’il existe un risque élevé de toxicité digestive. Lors de cette thèse, nous nous sommes intéressés à la quantification et correction des mouvements du volume cible irradié dans le cadre d’une radiothérapie pour un cancer de la prostate sans ou après ablation totale de la glande. Nous avons étudié un nouveau système d’imagerie basé sur la modalité ultrasons (US) permettant de visualiser la zone pelvienne grâce à deux voies d’acquisition : transabdominale (TA) et transpérinéale (TP). Contrairement aux systèmes US précédemment commercialisés, les mouvements entre les séances de simulation et de traitement (mouvements interfractions) sont quantifiés par recalage monomodal US/US. De plus, des images acquises avec la sonde TP en continu pendant l’irradiation permettent de quantifier les mouvements intrafractions du volume cible. Nous avons proposé une méthodologie d’évaluation des deux sondes US-TA et US-TP pour la correction des mouvements interfractions, en conditions cliniques. Les données US ont été comparées à celles obtenues par tomodensitométrie (CBCT), actuelle modalité de référence. De plus, nous avons quantifié pour la première fois les incertitudes liées à l’impact de la pression de la sonde sur la localisation du volume cible, et à la variabilité inter-opérateur du recalage manuel US/US. Nous avons observé pour la sonde TA une faible concordance entre les mouvements interfractions mesurés par US et CBCT, ainsi qu’une variabilité importante de la pression exercée par la sonde et du recalage manuel entre les opérateurs. Pour la sonde TP, nous avons proposé une méthode corrective de la localisation de l’image US de référence qui nous a permis de valider son utilisation en clinique. Les données recueillies avec la sonde TP ont montré une importante variation des amplitudes et fréquences des mouvements intrafractions, parfois supérieurs à 15mm, entre les patients et d’une séance à l’autre pour un même patient. Nous avons proposé une étude dosimétrique des conséquences de ces déplacements et ainsi démontré que l’impact sur la dose délivrée au volume cible est patient-dépendant, et est plus important lorsque le traitement est délivré avec une stratégie d’hypofractionnement. Nous avons démontré dans cette étude la faisabilité de l'implémentation clinique de la technique US-TP qui permet un repositionnement quotidien en début de séance sans dose additionnelle ou marqueurs invasifs, et la correction de la position du volume cible pendant l’irradiation.

The emergence of hypofractionated treatments implies an increase of precision on the…

Advisors/Committee Members: Sarrut, David (thesis director).

Subjects/Keywords: Imagerie médicale; Imagerie ultrasonore; Radiothérapie; Prostate; Ultrasound imaging; Radiotherapy; Prostate; 616.075 430 72

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APA (6^th Edition):

Fargier-Voiron, M. (2015). Performances d’un dispositif d’imagerie ultrasonore pour le suivi des mouvements prostatiques en radiothérapie : Ultrasound imaging modality for motion monitoring during prostate cancer radiotherapy. (Doctoral Dissertation). INSA Lyon. Retrieved from http://www.theses.fr/2015ISAL0119

Chicago Manual of Style (16^th Edition):

Fargier-Voiron, Marie. “Performances d’un dispositif d’imagerie ultrasonore pour le suivi des mouvements prostatiques en radiothérapie : Ultrasound imaging modality for motion monitoring during prostate cancer radiotherapy.” 2015. Doctoral Dissertation, INSA Lyon. Accessed January 16, 2021. http://www.theses.fr/2015ISAL0119.

MLA Handbook (7^th Edition):

Fargier-Voiron, Marie. “Performances d’un dispositif d’imagerie ultrasonore pour le suivi des mouvements prostatiques en radiothérapie : Ultrasound imaging modality for motion monitoring during prostate cancer radiotherapy.” 2015. Web. 16 Jan 2021.

Vancouver:

Fargier-Voiron M. Performances d’un dispositif d’imagerie ultrasonore pour le suivi des mouvements prostatiques en radiothérapie : Ultrasound imaging modality for motion monitoring during prostate cancer radiotherapy. [Internet] [Doctoral dissertation]. INSA Lyon; 2015. [cited 2021 Jan 16]. Available from: http://www.theses.fr/2015ISAL0119.

Council of Science Editors:

Fargier-Voiron M. Performances d’un dispositif d’imagerie ultrasonore pour le suivi des mouvements prostatiques en radiothérapie : Ultrasound imaging modality for motion monitoring during prostate cancer radiotherapy. [Doctoral Dissertation]. INSA Lyon; 2015. Available from: http://www.theses.fr/2015ISAL0119

Freie Universität Berlin

19. Maxeiner, Andreas. Evaluation der multi-parametrischen Magnet Resonanz Tomographie zur Detektion des Prostata Karzinoms.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12466

► Fragestellung: Evaluation der Anwendung der multiparametrischen (MP-) Magnet Resonanz Tomographie (MRT) im Rahmen der Prostata Biopsie (PB) bei Prostata Karzinom (PCa) Verdacht, MRT gestützt und… (more)

▼ Fragestellung: Evaluation der Anwendung der multiparametrischen (MP-) Magnet Resonanz Tomographie (MRT) im Rahmen der Prostata Biopsie (PB) bei Prostata Karzinom (PCa) Verdacht, MRT gestützt und MRT Ultraschall (US) fusioniert und im Rahmen der Beurteilung des biochemischen Reziviv (BCR) Risikos nach Prostatektomie. Die MP-MRT beinhaltet über die T2-gewichtete MRT (T2w-MRT) hinaus, die Protonen Magnet Resonanz Spektroskopie (1HMRS), die Diffusions gewichtete (DW-) MRT und die dynamische Kontrastmittel verstärkte (DCE-) MRT. Material und Methoden: Die erste Studie untersuchte retrospektiv das PCa BCR Risiko nach Prostatektomie mittels high resolution magic angle spinning (HRMAS) 1H-MRS bei 14 T von 48 unterschiedlichen Patienten. In der zweiten Studie wurde in 54 aufeinanderfolgenden Patienten eine MRT gestützte PB basierend auf MP-MRT Kriterien durchgeführt und die Treffergenauigkeit der MP- MRT ermittelt. Die dritte Studie verglich in 32 aufeinander folgenden Patienten die Detektionsraten für PCa in der MRT/US fusionierten Biopsie und der konventionellen systematischen transrektal (TR) US gestützten Biopsie. In dieser dritten Studie erhielten alle Patienten zuvor eine 3 T MP-MRT Untersuchung zur Lokalisation suspekter Läsionen, welche zunächst MRT/US fusioniert und abschließend konventionell TRUS gestützt gestanzt wurden. Ergebnisse: In der ersten Studie, unter Anwendung der Hauptkomponenten Analyse (HKA) auf die identifizierten 27 Haupt-Spektren in den Gruppen mit identisch klinischem Tumorstadium mit und ohne PCa Rezidiv konnten 4 Hauptkomponenten definiert werden, die in Zusammenhang mit einem Rezidiv gebracht werden konnten. Die mittels HKA und weiterführender kanonischer Diskriminanten Analyse gewonnenen Koeffizienten mit identisch klinischem Tumorstadium wurden schließlich als Prädiktoren auf die Gruppe mit identisch pathologischem Tumorstadium angewandt und es gelang ein biochemisches PCa Rezidiv mit einer Genauigkeit von 78 % in dieser Gruppe vorauszusagen. In der zweiten Studie wurden 54 aufeinanderfolgende Patienten in 178 Läsionen biopsiert, wovon 53 Stanzzylinder ein PCa enthielten. Detektionsraten bzw. falsch negative Testergebnisse waren wie folgt: T2w-MRT, 70 % und 50 %; T2w-MRT und 1H-MRS, 81 % und 32 %; T2w-MRT und DCE-MRT, 83 % und 29 %; T2w-MRT und DW-MRT, 85 % und 30 %; T2w-MRT, 1H-MRS, und DCE-MRT, 91 % und 13 %; T2w-MRT, 1H-MRS und DW-MRT, 94 % und 15 %; T2w-MRT, DW-MRT und DCE-MRT, 94 % und 13 %; T2w-MRT, 1H-MRS, DW-MRT und DCE-MRT, 100 % und 0 %. In der dritten Studie zeigte sich der proportionale Anteil an histologisch bestätigten Karzinomen in der MRT/US fusionierten Biopsie Gruppe (n = 32) (11/12; 34,4 %) signifikant höher (p = 0.01) als in der konventionellen TRUS gestützten Biopsie (6/12; 18.8 %). Schlussfolgerung: Zusammenfassend konnte in allen Studien ein signifikanter Informationsgewinn unter Hinzunahme der MP-MRT bzw. das Potential ein biochemisches Rezidiv vorauszusagen aufgezeigt werden. Advisors/Committee Members: m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: prostate cancer; prostate cancer imaging; multi-parametric magnetic resonance imaging; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maxeiner, A. (2014). Evaluation der multi-parametrischen Magnet Resonanz Tomographie zur Detektion des Prostata Karzinoms. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12466

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maxeiner, Andreas. “Evaluation der multi-parametrischen Magnet Resonanz Tomographie zur Detektion des Prostata Karzinoms.” 2014. Thesis, Freie Universität Berlin. Accessed January 16, 2021. http://dx.doi.org/10.17169/refubium-12466.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maxeiner, Andreas. “Evaluation der multi-parametrischen Magnet Resonanz Tomographie zur Detektion des Prostata Karzinoms.” 2014. Web. 16 Jan 2021.

Vancouver:

Maxeiner A. Evaluation der multi-parametrischen Magnet Resonanz Tomographie zur Detektion des Prostata Karzinoms. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Jan 16]. Available from: http://dx.doi.org/10.17169/refubium-12466.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maxeiner A. Evaluation der multi-parametrischen Magnet Resonanz Tomographie zur Detektion des Prostata Karzinoms. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-12466

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Durand, Matthieu. Imagerie expérimentale ex vivo de haute résolution à 7 tesla du cancer localisé de la prostate : 7T high resolution magnetic resonance imaging of prostate specimen : probing the radio-histological frontier.

Degree: Docteur es, Maladies des appareils digestif et urinaire, 2019, Université Lille II – Droit et Santé

URL: http://www.theses.fr/2019LIL2S015

►

L’IRM à 1,5T ou 3T de la prostate est l’imagerie la plus performante pour la détection du cancer de prostate. Nous avons travaillé à des… (more)

▼

L’IRM à 1,5T ou 3T de la prostate est l’imagerie la plus performante pour la détection du cancer de prostate. Nous avons travaillé à des modèles expérimentaux ex vivo d’IRM haute résolution à 7T permettant d’améliorer la résolution spatiale et la détection tumorale.La première partie de ce travail a porté sur la mise au point de protocoles d’analyse IRM de tissus prostatiques ex vivo à 7T. Des coupes de tissus de pièces opératoires et cadavériques avec et sans cancer ont été étudiées. Les données obtenues ont permis de définir des paramètres de séquence en turbo spin-echo pour obtenir des images avec résolution spatiale de 60 X 60 X 90 μm3. Cette résolution permettait d’identifier à l’imagerie IRM 7T des caractéristiques tissulaires comparables à celles obtenues par analyse histo-pathologique (X2).La seconde partie de ce travail a porté sur l’étude par IRM 7T de glandes prostatiques entières chez 18 patients opérés pour cancer de prostate. En utilisant les protocoles d’acquisition mis au point dans la première étude, l’imagerie a comporté des séquences T2, à la plus haute résolution de 130 X130 X195 μm3 et de diffusion avec cartographie ADC. Les résultats étaient interprétés par deux relecteurs en aveugle pour évaluer la qualité et la détection tumorale. La haute résolution spatiale des images, comparée à celle obtenue par analyse histo-pathologique, était jugée comme bonne avec une concordance inter-relecteur élevée. Une étude de corrélationanatomo-imagerie pour la détection du cancer avec analyse par secteur a montré une sensibilité de 70%, une spécificité de 80%, une valeur prédictive positive de 79% et une valeur prédictive négative de 72%.Ces résultats ont permis de mesurer la résolution de l’imagerie IRM à 7T ex vivo et son intérêt pour la détection du cancer. Une sémiologie IRM 7T du tissu prostatique doit être décrite. Ces résultats serviront de base à la translation future de l’imagerie actuelle vers l’IRM 7T in vivo chez l’homme.

Prostate MRI at 1.5T or 3T is the best imaging modality for tumor detection. Weinvestigated high resolution MRI at 7T on prostate specimen tissue to improve spatialresolution and prostate cancer detection.First part of experiments consisted of setting up new imaging protocol with 7T MRI onex vivo prostatic tissue. Imaging was carried out on all or part of specimen from radicalprostatectomy of patients or prostate harvested from deceased organ donors.Collected data resulted in new protocol parameters for fast spin echo needed to yielda spatial resolution of 60 X 60 X 90 μm3. High spatial resolution imaging was used toidentify relevant morphological structures for characterization of the prostate gland andtumor as compared to histology.Second part of work was done with whole gland imaging at 7T of radical prostatectomyspecimens of patients. Imaging protocol was based on the outcomes from the first partof experiments and consisted in T2W with high resolution of 130 X130 X195 μm3,diffusion and ADC map. Two independent and blinded reviewers were in charge ofimaging quality assessment…

Advisors/Committee Members: Villers, Arnaud (thesis director).

Subjects/Keywords: Cancer de la prostate; Diagnostic; Imagerie; Résonance magnétique nucléaire; Prostate cancer; Diagnosis; Imaging; Magnetic resonance imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Durand, M. (2019). Imagerie expérimentale ex vivo de haute résolution à 7 tesla du cancer localisé de la prostate : 7T high resolution magnetic resonance imaging of prostate specimen : probing the radio-histological frontier. (Doctoral Dissertation). Université Lille II – Droit et Santé. Retrieved from http://www.theses.fr/2019LIL2S015

Chicago Manual of Style (16^th Edition):

Durand, Matthieu. “Imagerie expérimentale ex vivo de haute résolution à 7 tesla du cancer localisé de la prostate : 7T high resolution magnetic resonance imaging of prostate specimen : probing the radio-histological frontier.” 2019. Doctoral Dissertation, Université Lille II – Droit et Santé. Accessed January 16, 2021. http://www.theses.fr/2019LIL2S015.

MLA Handbook (7^th Edition):

Durand, Matthieu. “Imagerie expérimentale ex vivo de haute résolution à 7 tesla du cancer localisé de la prostate : 7T high resolution magnetic resonance imaging of prostate specimen : probing the radio-histological frontier.” 2019. Web. 16 Jan 2021.

Vancouver:

Durand M. Imagerie expérimentale ex vivo de haute résolution à 7 tesla du cancer localisé de la prostate : 7T high resolution magnetic resonance imaging of prostate specimen : probing the radio-histological frontier. [Internet] [Doctoral dissertation]. Université Lille II – Droit et Santé 2019. [cited 2021 Jan 16]. Available from: http://www.theses.fr/2019LIL2S015.

Council of Science Editors:

Durand M. Imagerie expérimentale ex vivo de haute résolution à 7 tesla du cancer localisé de la prostate : 7T high resolution magnetic resonance imaging of prostate specimen : probing the radio-histological frontier. [Doctoral Dissertation]. Université Lille II – Droit et Santé 2019. Available from: http://www.theses.fr/2019LIL2S015

Boston University

21. Baker, Adam Timothy. Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer.

Degree: MS, Bioimaging, 2018, Boston University

URL: http://hdl.handle.net/2144/33003

► The extension from Quantitative Magnetic Resonance Imaging to synthetic imaging has the clear advantage of being able to continually image the patient after the exam.… (more)

Subjects/Keywords: Medical imaging; Diffusion weighted imaging; Contrast-to-noise; Prostate cancer; Quantitative magnetic resonance imaging; Signal-to-noise; Synthetic magnetic resonance imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Baker, A. T. (2018). Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/33003

Chicago Manual of Style (16^th Edition):

Baker, Adam Timothy. “Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer.” 2018. Masters Thesis, Boston University. Accessed January 16, 2021. http://hdl.handle.net/2144/33003.

MLA Handbook (7^th Edition):

Baker, Adam Timothy. “Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer.” 2018. Web. 16 Jan 2021.

Vancouver:

Baker AT. Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2144/33003.

Council of Science Editors:

Baker AT. Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/33003

UCLA

22. Cao, Ruiming. Prostate Cancer Diagnosis from Multi-parametric Magnetic Resonance Imaging via Deep Learning.

Degree: Computer Science, 2019, UCLA

URL: http://www.escholarship.org/uc/item/0815r9gk

► Prostate cancer (PCa) is one of the most common cancer-related diseases among men in the United States. Multi-parametric magnetic resonance imaging (mp-MRI) is considered the… (more)

Subjects/Keywords: Computer science; Medical imaging; Computer-aided diagnosis; Deep learning; Magnetic resonance imaging; Prostate cancer

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APA (6^th Edition):

Cao, R. (2019). Prostate Cancer Diagnosis from Multi-parametric Magnetic Resonance Imaging via Deep Learning. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/0815r9gk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cao, Ruiming. “Prostate Cancer Diagnosis from Multi-parametric Magnetic Resonance Imaging via Deep Learning.” 2019. Thesis, UCLA. Accessed January 16, 2021. http://www.escholarship.org/uc/item/0815r9gk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cao, Ruiming. “Prostate Cancer Diagnosis from Multi-parametric Magnetic Resonance Imaging via Deep Learning.” 2019. Web. 16 Jan 2021.

Vancouver:

Cao R. Prostate Cancer Diagnosis from Multi-parametric Magnetic Resonance Imaging via Deep Learning. [Internet] [Thesis]. UCLA; 2019. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/0815r9gk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cao R. Prostate Cancer Diagnosis from Multi-parametric Magnetic Resonance Imaging via Deep Learning. [Thesis]. UCLA; 2019. Available from: http://www.escholarship.org/uc/item/0815r9gk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

23. Obando Andrade, A.V. (author). Optimizing a RF Coil for Prostate Imaging at 7 Tesla MRI.

Degree: 2014, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:0db17e0e-9032-4a59-ac8f-ac2cc89756e6

►

Ultra-high ?eld prostate MR imaging (?7T) becomes increasingly difficult due to insufficient radio frequency ?eld excitation penetration. RF coils used at ultra-high ?elds are adapted… (more)

▼

Ultra-high ?eld prostate MR imaging (?7T) becomes increasingly difficult due to insufficient radio frequency ?eld excitation penetration. RF coils used at ultra-high ?elds are adapted from lower ?eld strengths but their performance is suboptimal. These coils are designed as near-?eld antennas; however, better signal penetration can be obtained using far-?eld concept, speci?cally in the case of prostate which is located deep in the body. In this project the optimization of an RF coil for prostate imaging at 7T Magnetic Resonance system is investigated. This RF coil was designed following far-?eld-based concept recently proposed by Raaijmakers et al., who has demonstrated that higher transmit B1+ at depth can be obtained; thus increasing the transmit performance necessary to acquire good images. The RF coil consists of a fractionated dipole antenna mounted on an acrylic substrate, and it is used as part of a surface array. The optimization is evaluated in terms of safety (local SAR), transmit performance (B1+), and coupling measurements. A parameters study was performed to improve the performance of the RF coil. Numerical simulations were used to evaluate new designs obtained from the parameters study. From the simulated results, three designs were constructed for validation purposes. Two different measurements were performed to validate the simulations: B1 measurements in the 7 Tesla MR scanner and coupling measurements with a network analyzer; these measurements were performed on a phantom with tissue electrical properties. Finally, an in vivo measurement using two identical sinusoidal-shaped snake antennas (s20) aligned on the pelvis was performed to image a healthy prostate. Both, simulations and measurements in the snake antennas demonstrated that despite the improvement gained in safety with lower levels of SAR, the radiation ?eld penetration pattern is less homogeneous affecting the imaging process. Therefore, these antennas might show more efficiency imaging regions of interest where safety has to be ensured such as the heart, but for prostate imaging the fractionated dipole is preferable.

Biomedical Engineering

Mechanical, Maritime and Materials Engineering

Advisors/Committee Members: Raaijmakers, A. (mentor), Remis, R. (mentor).

Subjects/Keywords: Magnetic Resonance Imaging; 7T; Prostate Imaging; RF coilsu; ultra-high field MRI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Obando Andrade, A. V. (. (2014). Optimizing a RF Coil for Prostate Imaging at 7 Tesla MRI. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:0db17e0e-9032-4a59-ac8f-ac2cc89756e6

Chicago Manual of Style (16^th Edition):

Obando Andrade, A V (author). “Optimizing a RF Coil for Prostate Imaging at 7 Tesla MRI.” 2014. Masters Thesis, Delft University of Technology. Accessed January 16, 2021. http://resolver.tudelft.nl/uuid:0db17e0e-9032-4a59-ac8f-ac2cc89756e6.

MLA Handbook (7^th Edition):

Obando Andrade, A V (author). “Optimizing a RF Coil for Prostate Imaging at 7 Tesla MRI.” 2014. Web. 16 Jan 2021.

Vancouver:

Obando Andrade AV(. Optimizing a RF Coil for Prostate Imaging at 7 Tesla MRI. [Internet] [Masters thesis]. Delft University of Technology; 2014. [cited 2021 Jan 16]. Available from: http://resolver.tudelft.nl/uuid:0db17e0e-9032-4a59-ac8f-ac2cc89756e6.

Council of Science Editors:

Obando Andrade AV(. Optimizing a RF Coil for Prostate Imaging at 7 Tesla MRI. [Masters Thesis]. Delft University of Technology; 2014. Available from: http://resolver.tudelft.nl/uuid:0db17e0e-9032-4a59-ac8f-ac2cc89756e6

Rutgers University

24. Chowdhury, A.K. Najeebullah, 1987-. Concurrent segmentation of the prostate on MRI and CT via linked statistical shape models for radiotherapy planning.

Degree: Biomedical Engineering, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063357

Subjects/Keywords: Prostate – Cancer—Radiotherapy; Prostate—Magnetic resonance imaging; Prostate—Cross-sectional imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chowdhury, A.K. Najeebullah, 1. (2011). Concurrent segmentation of the prostate on MRI and CT via linked statistical shape models for radiotherapy planning. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063357

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chowdhury, A.K. Najeebullah, 1987-. “Concurrent segmentation of the prostate on MRI and CT via linked statistical shape models for radiotherapy planning.” 2011. Thesis, Rutgers University. Accessed January 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063357.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chowdhury, A.K. Najeebullah, 1987-. “Concurrent segmentation of the prostate on MRI and CT via linked statistical shape models for radiotherapy planning.” 2011. Web. 16 Jan 2021.

Vancouver:

Chowdhury, A.K. Najeebullah 1. Concurrent segmentation of the prostate on MRI and CT via linked statistical shape models for radiotherapy planning. [Internet] [Thesis]. Rutgers University; 2011. [cited 2021 Jan 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063357.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chowdhury, A.K. Najeebullah 1. Concurrent segmentation of the prostate on MRI and CT via linked statistical shape models for radiotherapy planning. [Thesis]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063357

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

25. Silverman, Matthew John. Determination of Functional Activity of Sodium Glucose Transporters in Cancer.

Degree: Chemical Engineering, 2014, UCLA

URL: http://www.escholarship.org/uc/item/1rj3h2xh

► As cancer incidence continues to rise in the United States, there remains an increasing demand for new tools for oncologists to use for both diagnosing… (more)

▼ As cancer incidence continues to rise in the United States, there remains an increasing demand for new tools for oncologists to use for both diagnosing and directing treatments for cancer. Among these tools, Positron Emission Tomography (PET) has been rising in prominence in recent decades as a useful tool for monitoring the metabolic activity of organs and tissues in vivo. Unlike Computed Tomography (CT), Magnetic Resonance Imaging (MRI) or Ultrasound (US), PET imaging allows medical professionals and researchers to use molecular imaging probes to measure metabolic activity of tissues, opening up a different dimension of medical evaluation. In PET imaging for cancer, 2-deoxy-2-[F-18]fluoro-D-glucose (2-FDG) has been the historically dominant molecular probe used, since 2-FDG uptake occurs via facilitative glucose transporters (GLUTs), and its tissue accumulation reflects hexokinase (HK) activity in proportion to the glucose metabolic rate. In many cancers, glucose utilization through these transporters increases dramatically relative to non-cancerous tissue, making 2-FDG a valuable molecular imaging probe in detecting and monitoring the progression of cancer. However, there are some cancers that don't show consistently increased 2-FDG uptake, rendering 2-FDG PET less effective in these situations for medical diagnosis. Recent work has suggested the possibility that another class of glucose transporters, sodium glucose transporters (SGLTs), is expressed and active in a variety of cancers. SGLT activity, which cannot be measured by 2-FDG PET, could offer an explanation as to why 2-FDG accumulation seems less significant in some cancers. While there have been several publications examining mRNA and protein SGLT expression in cancer, there has yet to be any data confirming functional SGLT activity in vivo. In this work, we present initial data on the functional activity of SGLTs in cancerous cells from both prostate and pancreatic cancer both in vitro and in vivo. Using methyl-4-deoxy-4-[F-18]fluoro-D-glucopyranoside (Me-4FDG), a PET molecular imaging probe specific for SGLTs, we identify SGLT activity in cancer cell lines, animal tumor xenografts, and human tumors. These results usher in the novel possibility of utilizing SGLT PET imaging molecular imaging probes for diagnosing and characterizing cancerous tumors.

Subjects/Keywords: Chemical engineering; Pharmacology; Cancer; Imaging; Pancreatic; PET; Prostate; SGLT

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silverman, M. J. (2014). Determination of Functional Activity of Sodium Glucose Transporters in Cancer. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/1rj3h2xh

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silverman, Matthew John. “Determination of Functional Activity of Sodium Glucose Transporters in Cancer.” 2014. Thesis, UCLA. Accessed January 16, 2021. http://www.escholarship.org/uc/item/1rj3h2xh.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silverman, Matthew John. “Determination of Functional Activity of Sodium Glucose Transporters in Cancer.” 2014. Web. 16 Jan 2021.

Vancouver:

Silverman MJ. Determination of Functional Activity of Sodium Glucose Transporters in Cancer. [Internet] [Thesis]. UCLA; 2014. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/1rj3h2xh.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silverman MJ. Determination of Functional Activity of Sodium Glucose Transporters in Cancer. [Thesis]. UCLA; 2014. Available from: http://www.escholarship.org/uc/item/1rj3h2xh

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

26. Jiang, Ziyue. Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models.

Degree: Molec & Med Pharmacology, 2013, UCLA

URL: http://www.escholarship.org/uc/item/91s7n4ps

► The advanced stage of prostate cancer is the second leading cause of cancer-related death for American men. Novel, effective treatment options and more cancer-specific diagnostic… (more)

▼ The advanced stage of prostate cancer is the second leading cause of cancer-related death for American men. Novel, effective treatment options and more cancer-specific diagnostic tools are urgently needed to facilitate patient management. Here, we explored the construction and application of an array of gene-based molecular imaging and therapeutic vectors in a variety of clinically relevant settings. These vectors exploit prostate cancer-specific promoters to control the transcription of imaging reporter genes or therapeutic genes, and thus can achieve stringent cancer selectivity. We showed that gene-based imaging vectors can detect prostate cancer metastasis earlier than conventional imaging modalities; we also developed a dual-reporter imaging system that can specifically interrogate the activation/inhibition status of androgen receptor, and thus monitor the efficacy of androgen deprivation and androgen receptor blockade therapies. Further, we explored the applicability of gene-based vectors in detecting circulating tumor cells and have obtained promising results. Moreover, we employed two strategies to improve the clinical usability of viral vectors in immunocompetent hosts (such as humans). In the first strategy, we used a broad-acting immunosuppressant, rapamycin, to reduce the scale of adenovirus-induced inflammatory responses and also to decrease the eliminating effects of host adaptive immune system on viral vectors and viral-infected, transgene-expressing cells. Rapamycin significantly augmented the magnitude and prolonged the duration of virus-delivered transgene expression, and thus enhanced the diagnostic capability of these imaging vectors. The second approach took advantage of the versatile surface modifying ability of non-viral reagents. We designed a polypeptide coating that can non-covalently bind to adenoviral particles and confer protections against blood components such as neutralizing antibodies and coagulation factors. The coating significantly decreased the inhibitory effects of neutralizing antibodies on adenoviral transduction and markedly abrogated coagulation factors-mediated hepatocyte infection. Furthermore, this polypeptide coating reduced the antigenicity of adenoviral vectors in vivo, greatly diminished anti-adenovirus antibody production, and therefore could facilitate repeated administration of viral vectors in immunocompetent hosts. Overall, we herein present a substantial amount of evidence supporting the pre-clinical and translational use of gene-based imaging and therapeutic vectors to assist the management of patients with advanced, treatment-refractory prostate cancer.

Subjects/Keywords: Pharmacology; adenoviral vectors; castration-resistance; immunosuppression; metastasis; molecular imaging; prostate cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jiang, Z. (2013). Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/91s7n4ps

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jiang, Ziyue. “Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models.” 2013. Thesis, UCLA. Accessed January 16, 2021. http://www.escholarship.org/uc/item/91s7n4ps.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jiang, Ziyue. “Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models.” 2013. Web. 16 Jan 2021.

Vancouver:

Jiang Z. Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models. [Internet] [Thesis]. UCLA; 2013. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/91s7n4ps.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jiang Z. Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models. [Thesis]. UCLA; 2013. Available from: http://www.escholarship.org/uc/item/91s7n4ps

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ryerson University

27. Vafaie, Rasa. A Fast, Fully Automated Prostate Boundary Segmentation Using Probabilistic Approaches In Ultrasound Images.

Degree: 2012, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A2452

► Segmentation of prostate boundaries in transrectal ultrasound (TRUS) images plays a great role in prostate cancer diagnosis. Due to the low signal to noise ratio… (more)

Subjects/Keywords: Prostate – Ultrasonic imaging; Ultrasonics in medicine; Image processing – Digital techniques

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vafaie, R. (2012). A Fast, Fully Automated Prostate Boundary Segmentation Using Probabilistic Approaches In Ultrasound Images. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A2452

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vafaie, Rasa. “A Fast, Fully Automated Prostate Boundary Segmentation Using Probabilistic Approaches In Ultrasound Images.” 2012. Thesis, Ryerson University. Accessed January 16, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A2452.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vafaie, Rasa. “A Fast, Fully Automated Prostate Boundary Segmentation Using Probabilistic Approaches In Ultrasound Images.” 2012. Web. 16 Jan 2021.

Vancouver:

Vafaie R. A Fast, Fully Automated Prostate Boundary Segmentation Using Probabilistic Approaches In Ultrasound Images. [Internet] [Thesis]. Ryerson University; 2012. [cited 2021 Jan 16]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A2452.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vafaie R. A Fast, Fully Automated Prostate Boundary Segmentation Using Probabilistic Approaches In Ultrasound Images. [Thesis]. Ryerson University; 2012. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A2452

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

28. Alshammari, Meshari Turki. Treatment planning and dosimetric verification of cyberknife prostate SBRT (stereotactic body radiation therapy) on an MR-based 3D prostate model imaging insert in a pelvis phantom.

Degree: MS, Bioimaging, 2016, Boston University

URL: http://hdl.handle.net/2144/16805

► Purpose of this study was to validate a novel CyberKnife stereotactic body radiotherapy (SBRT) treatment planning on an MRI-based 3D prostate model insert in an… (more)

▼ Purpose of this study was to validate a novel CyberKnife stereotactic body radiotherapy (SBRT) treatment planning on an MRI-based 3D prostate model insert in an anthropomorphic pelvis phantom using Gafchromic EBT3 films to perform dosimetric measurements. The methodology of this study is based on a pelvis phantom and a physical printed 3D model of the prostate with dominant intra-prostatic-lesion and surrounding organs at risk segmented from a patient MR images. Cyberknife prostate treatment planning was performed to have at least 95% the planning target volumes (PTV: prostate expanded with margins of 5 mm in all directions except 3 mm posteriorly) covered by 3625 cGy (725x5) and a simultaneous dose escalation to 4750 cGy on the dominant intra-prostatic-lesion. Plan dosimetry verification was performed using Gafchromic EBT3 films on a Stereotactic Dose Verification Phantom. First, film calibration was done on Gafchromic EBT3 films exposed to various doses of 0-2500 cGy based on a LINAC (Trilogy) and CyberKnife monthly quality assurance (QA) for machine output calibration. Second, absolute dose measurements were taken by using films within the dose range 0-2250 cGy. Third, Gafchromic EBT3 films were placed in coronal and sagittal planes on the standard “blue phantom” or Stereotactic Dose Verification Phantom (SDVP) on which one fraction of the treatment plan is delivered for verification measurements. Then, on the prostate-pelvis phantom, a dosimetry inserts were used with films through the DIL region. After the calibration, the accuracy of absolute dose measurements with EBT3 was verified to be ≤ 1% in the dose range of interest (500-1500 cGy). On the SDVP phantom, comparison of films vs. plan for the coronal plane yielded ≥ 99.7% passing rates while for sagittal plane yielded ≥ 95.3% passing rates under the gamma criteria of ≤ 2% in dose and ≤ 2mm in distance to agreement (DTA). This study demonstrated that it is feasible to plan and deliver a SBRT treatment to prostate with a simultaneous dose escalation to the dominant intra-prostatic lesion.

Subjects/Keywords: Medical imaging; MRI; Oncology; Prostate; Quality assurance; Radiation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alshammari, M. T. (2016). Treatment planning and dosimetric verification of cyberknife prostate SBRT (stereotactic body radiation therapy) on an MR-based 3D prostate model imaging insert in a pelvis phantom. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16805

Chicago Manual of Style (16^th Edition):

Alshammari, Meshari Turki. “Treatment planning and dosimetric verification of cyberknife prostate SBRT (stereotactic body radiation therapy) on an MR-based 3D prostate model imaging insert in a pelvis phantom.” 2016. Masters Thesis, Boston University. Accessed January 16, 2021. http://hdl.handle.net/2144/16805.

MLA Handbook (7^th Edition):

Alshammari, Meshari Turki. “Treatment planning and dosimetric verification of cyberknife prostate SBRT (stereotactic body radiation therapy) on an MR-based 3D prostate model imaging insert in a pelvis phantom.” 2016. Web. 16 Jan 2021.

Vancouver:

Alshammari MT. Treatment planning and dosimetric verification of cyberknife prostate SBRT (stereotactic body radiation therapy) on an MR-based 3D prostate model imaging insert in a pelvis phantom. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2144/16805.

Council of Science Editors:

Alshammari MT. Treatment planning and dosimetric verification of cyberknife prostate SBRT (stereotactic body radiation therapy) on an MR-based 3D prostate model imaging insert in a pelvis phantom. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/16805

29. Hamdan, Iyas. Multimodal Image Registration in Image-Guided Prostate Brachytherapy : Recalage d'images multimodales en curiethérapie de la prostate.

Degree: Docteur es, Sciences et Technologies de l'Information et de la Communication, 2017, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire

URL: http://www.theses.fr/2017IMTA0002

► Le cancer de la prostate est le cancer le plus fréquent chez l'homme en France et aux pays occidentaux. Il est la troisième cause de… (more)

▼ Le cancer de la prostate est le cancer le plus fréquent chez l'homme en France et aux pays occidentaux. Il est la troisième cause de décès liés au cancer, étant responsable d'environ 10% des morts. La curiethérapie, une technique de radiothérapie, est liée à une meilleure qualité de vie après le traitement, par rapport aux autres méthodes de traitement. La curiethérapie de la prostate consiste à insérer des sources radioactives dans la prostate afin de délivrer une dose d'irradiation localisée à la tumeur tout en protégeant les tissus sains environnants. L'imagerie multimodale est utilisée afin d'améliorer la précision du traitement. Les images Tomodensitométriques préopératoires, appelées Computed Tomography (CT), peuvent être utilisées pour calculer une distribution personnalisée et plus précise de dose. Pendant l'intervention, le chirurgien utilise un système de guidage temps-réel par l'Ultrason Transrectale, Transrectal Ultrasound (TRUS), pour placer correctement les sources radioactives dans leurs positions souhaitées. Par conséquent, si les positions des sources sont déterminées sur l'image CT, elles doivent être transférées à l'image US. Cependant, un recalage US/CT direct et robuste est difficilement envisageable parce que les tissus mous, telle que la prostate, offrent peu de contraste en CT et en US. En revanche, l'Imagerie par Résonance Magnétique (IRM) fournit un meilleur contraste et peut, potentiellement, améliorer le traitement en améliorant la visualisation. Donc, ces trois modalités (IRM, CT et US) doivent être correctement alignées. Pour compenser les déformations de la prostate, due au changement de taille et forme entre les différentes acquisitions, un recalage non-rigide est nécessaire. Une méthode de recalage entièrement automatique est nécessaire, afin de faciliter son intégration au bloc opératoire. Nous proposons dans un premier temps un recalage IRM/CT basé sur la maximisation de l'information mutuelle en combinaison avec un champ de déformation paramétré par B-Splines. Nous proposons de contraindre le recalage sur des volumes d'intérêt (VOIs) afin d'améliorer la robustesse et le temps de calcul. L'approche proposée a été validée sur des jeux de données cliniques. Une évaluation quantitative a montré que l'erreur de recalage est égale à 1.15±0.20 mm; qui répond à la précision clinique souhaitée. Ensuite, nous proposons un deuxième recalage US/IRM, où nous utilisons une approche multi-résolution pour éviter les minima locaux et améliorer le temps de calcul. Un critère de similarité, qui met en corrélation l'intensité de l'image US avec l'intensité ainsi que le gradient de l'image IRM, a été utilisé afin de trouver la transformation qui aligne les deux images. Cette méthode a été validée sur un fantôme de prostate dans un premier temps pour évaluer sa faisabilité. Ensuite, elle a été validée sur des jeux de données cliniques en utilisant des critères qualitatives et quantitatives. La distance Hausdorff a montré que l'erreur de recalage est égale à 1.44±0.06 mm. L'approche proposée dans ce… Advisors/Committee Members: Visvikis, Dimitris (thesis director).

Subjects/Keywords: Curiethérapie; Prostate; Imagerie multimodal; Recalage d'images; Brachytherapy; Multimodal Imaging; Image Registration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamdan, I. (2017). Multimodal Image Registration in Image-Guided Prostate Brachytherapy : Recalage d'images multimodales en curiethérapie de la prostate. (Doctoral Dissertation). Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire. Retrieved from http://www.theses.fr/2017IMTA0002

Chicago Manual of Style (16^th Edition):

Hamdan, Iyas. “Multimodal Image Registration in Image-Guided Prostate Brachytherapy : Recalage d'images multimodales en curiethérapie de la prostate.” 2017. Doctoral Dissertation, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire. Accessed January 16, 2021. http://www.theses.fr/2017IMTA0002.

MLA Handbook (7^th Edition):

Hamdan, Iyas. “Multimodal Image Registration in Image-Guided Prostate Brachytherapy : Recalage d'images multimodales en curiethérapie de la prostate.” 2017. Web. 16 Jan 2021.

Vancouver:

Hamdan I. Multimodal Image Registration in Image-Guided Prostate Brachytherapy : Recalage d'images multimodales en curiethérapie de la prostate. [Internet] [Doctoral dissertation]. Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire; 2017. [cited 2021 Jan 16]. Available from: http://www.theses.fr/2017IMTA0002.

Council of Science Editors:

Hamdan I. Multimodal Image Registration in Image-Guided Prostate Brachytherapy : Recalage d'images multimodales en curiethérapie de la prostate. [Doctoral Dissertation]. Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire; 2017. Available from: http://www.theses.fr/2017IMTA0002

University of California – San Francisco

30. Korn, Natalie. A Multiparametric MRI for the Classification and Grading of Prostate Cancer.

Degree: Bioengineering, 2019, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/30p0x6mt

► Prostate cancer is one of the most common diseases in men worldwide, however only a small percentage of men with prostate cancer have aggressive cancer,… (more)

Subjects/Keywords: Medical imaging; Diffusion; Hyperpolarization; MRI; Multiparametric; Prostate; Staging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Korn, N. (2019). A Multiparametric MRI for the Classification and Grading of Prostate Cancer. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/30p0x6mt

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Korn, Natalie. “A Multiparametric MRI for the Classification and Grading of Prostate Cancer.” 2019. Thesis, University of California – San Francisco. Accessed January 16, 2021. http://www.escholarship.org/uc/item/30p0x6mt.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Korn, Natalie. “A Multiparametric MRI for the Classification and Grading of Prostate Cancer.” 2019. Web. 16 Jan 2021.

Vancouver:

Korn N. A Multiparametric MRI for the Classification and Grading of Prostate Cancer. [Internet] [Thesis]. University of California – San Francisco; 2019. [cited 2021 Jan 16]. Available from: http://www.escholarship.org/uc/item/30p0x6mt.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Korn N. A Multiparametric MRI for the Classification and Grading of Prostate Cancer. [Thesis]. University of California – San Francisco; 2019. Available from: http://www.escholarship.org/uc/item/30p0x6mt

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations